                         SEQUENCE LISTING

<110>  The University of Maryland, College Park
       Children's National Medical Center
       Ayyub, Omar Bilal
       Behrens, Adam Michael
       Kofinas, Peter
       Summar, Marshall  Lynn
       Cabrera-Luque, Juan Manuel
       Cunningham, Gary
 
<120>  DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF 
       HYPERAMMONEMIA

<130>  140695.00702

<140>  PCT/US14/53756
<141>  2014-09-02

<150>  US 61/872,149
<151>  2013-08-30

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dehydrogenase mutant 1

<400>  1

Met Asn Thr Val Thr Asn Gln Trp Lys Ala Val Asp Ile Phe Thr Gln 
1               5                   10                  15      


Ile Arg Asp His Glu Gln Val Val Phe Cys Asn Asp Lys Asn Thr Gly 
            20                  25                  30          


Leu Lys Ala Ile Ile Ala Ile His Asp Thr Thr Leu Gly Pro Ala Leu 
        35                  40                  45              


Gly Gly Cys Arg Met Tyr Pro Tyr Ala Thr Val Glu Asp Ala Leu Phe 
    50                  55                  60                  


Asp Val Leu Arg Leu Ser Lys Gly Met Thr Tyr Lys Cys Leu Ala Ala 
65                  70                  75                  80  


Asp Val Asp Phe Gly Gly Gly Lys Ala Val Ile Ile Gly Asp Pro His 
                85                  90                  95      


Lys Asp Lys Thr Pro Glu Leu Phe Arg Ala Phe Gly Gln Phe Val Glu 
            100                 105                 110         


Ser Leu Asn Gly Arg Phe Tyr Thr Gly Thr Asp Met Gly Thr Thr Pro 
        115                 120                 125             


Asp Asp Phe Val His Ala Met Lys Glu Thr Asn Cys Ile Val Gly Val 
    130                 135                 140                 


Pro Glu Glu Tyr Gly Gly Ser Gly Asp Ser Ser Val Pro Thr Ala Leu 
145                 150                 155                 160 


Gly Val Ile Tyr Gly Ile Gln Ala Thr Asn Lys Val Ile Trp Gly Ser 
                165                 170                 175     


Asp Glu Leu His Gly Lys Thr Tyr Ala Ile Gln Gly Leu Gly Lys Val 
            180                 185                 190         


Gly Arg Lys Val Ala Glu Arg Leu Leu Lys Glu Gly Ala Asp Leu Tyr 
        195                 200                 205             


Val Cys Asp Ile His Pro Thr Ala Ile Glu Ala Ile Val Ser Tyr Ala 
    210                 215                 220                 


Lys Lys Leu Gly Ala Asn Val Lys Val Val Gln Gly Thr Glu Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Ala Asp Ile Phe Val Pro Cys Ala Phe Gly Asn Val Val 
                245                 250                 255     


Asn Asp Asn Thr Ile His Val Leu Lys Val Lys Ala Ile Val Gly Ser 
            260                 265                 270         


Ala Asn Asn Gln Leu Leu Asp Val Arg His Gly Gln Leu Leu Lys Glu 
        275                 280                 285             


Lys Gly Ile Leu Tyr Ala Pro Asp Tyr Ile Val Asn Ala Gly Gly Leu 
    290                 295                 300                 


Ile Gln Val Ala Asp Glu Leu Tyr Gly Leu Asn Lys Glu Arg Val Leu 
305                 310                 315                 320 


Gln Lys Thr Lys Ala Ile Tyr Ser Thr Leu Leu His Ile Tyr Ser Arg 
                325                 330                 335     


Ala Glu Ala Asp His Ile Thr Thr Ile Glu Ala Ala Asn Arg Phe Cys 
            340                 345                 350         


Glu Glu Arg Leu Gln Gln Arg Ser Arg Arg Asn Asp Phe Phe Thr His 
        355                 360                 365             


Arg Lys Gln Pro Lys Trp Asp Ile Arg Arg 
    370                 375             


<210>  2
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Enzyme 2

<400>  2

Met Arg Asp Val Phe Glu Met Met Asp Arg Tyr Gly His Glu Gln Val 
1               5                   10                  15      


Ile Phe Cys Arg His Pro Gln Thr Gly Leu Lys Ala Ile Ile Ala Leu 
            20                  25                  30          


His Asn Thr Thr Ala Gly Pro Ala Leu Gly Gly Cys Arg Met Ile Pro 
        35                  40                  45              


Tyr Ala Ser Thr Asp Glu Ala Leu Glu Asp Val Leu Arg Leu Ser Lys 
    50                  55                  60                  


Gly Met Thr Tyr Lys Cys Ser Leu Ala Asp Val Asp Phe Gly Gly Gly 
65                  70                  75                  80  


Lys Met Val Ile Ile Gly Asp Pro Lys Lys Asp Lys Ser Pro Glu Leu 
                85                  90                  95      


Phe Arg Val Ile Gly Arg Phe Val Gly Gly Leu Asn Gly Arg Phe Tyr 
            100                 105                 110         


Thr Gly Thr Asp Met Gly Thr Asn Pro Glu Asp Phe Val His Ala Ala 
        115                 120                 125             


Arg Glu Ser Lys Ser Phe Ala Gly Leu Pro Lys Ser Tyr Gly Gly Lys 
    130                 135                 140                 


Gly Asp Thr Ser Ile Pro Thr Ala Leu Gly Val Phe His Gly Met Arg 
145                 150                 155                 160 


Ala Thr Ala Arg Phe Leu Trp Gly Thr Asp Gln Leu Lys Gly Arg Val 
                165                 170                 175     


Val Ala Ile Gln Gly Val Gly Lys Val Gly Glu Arg Leu Leu Gln Leu 
            180                 185                 190         


Leu Val Glu Val Gly Ala Tyr Cys Lys Ile Ala Asp Ile Asp Ser Val 
        195                 200                 205             


Arg Cys Glu Gln Leu Lys Glu Lys Tyr Gly Asp Lys Val Gln Leu Val 
    210                 215                 220                 


Asp Val Asn Arg Ile His Lys Glu Ser Cys Asp Ile Phe Ser Pro Cys 
225                 230                 235                 240 


Ala Lys Gly Gly Val Val Asn Asp Asp Thr Ile Asp Glu Phe Arg Cys 
                245                 250                 255     


Leu Ala Ile Val Gly Ser Ala Asn Asn Gln Leu Val Glu Asp Arg His 
            260                 265                 270         


Gly Ala Leu Leu Gln Lys Arg Ser Ile Cys Tyr Ala Pro Asp Tyr Leu 
        275                 280                 285             


Val Asn Ala Gly Gly Leu Ile Gln Val Ala Asp Glu Leu Glu Gly Phe 
    290                 295                 300                 


His Glu Glu Arg Val Leu Ala Lys Thr Glu Ala Ile Tyr Asp Met Val 
305                 310                 315                 320 


Leu Asp Ile Phe His Arg Ala Lys Asn Glu Asn Ile Thr Thr Cys Glu 
                325                 330                 335     


Ala Ala Asp Arg Ile Val Met Glu Arg Leu Lys Lys Leu Thr Asp Ile 
            340                 345                 350         


Arg Arg Ile Leu Leu Glu Asp Pro Arg Asn Ser Ala Arg Arg 
        355                 360                 365     


<210>  3
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding enzyme 3

<400>  3
atggaaatct tcgaggaaat caaacggcgg ggacacgagc aaattctgtt caattatgat       60

cgggcttccg gtttgaaagc aattatcgcc attcacaata ctacgttggg gccggcgttg      120

ggcgggtgcc gaatgttacc gtatcaaacg gaagaggcgg ccctcgagga tgcgctgcgg      180

ttgtcggaag ggatgaccta taaagcggcc gccgccgggc tcgatttcgg cgggggcaaa      240

acggtgatta tcggggatcc gatgaaagac aagtccgagg ccctgtttcg tgcgctcggg      300

cgttttatcg agaccttgaa aggccgttac cttacgggag aagacgtagg aaccaacgaa      360

gaagattttg tctgggctcg tcgggaaacc cgttatgttg tcggattgcc gccggcttat      420

ggcgggtccg gcgatacggg tgacaatacc gcgcgcggcg tcattcaagc gatgcgcgcc      480

gcgttgatgc accggtacgg ttcgccggat ctccagggcc ggcggattgc cgtccaaggg      540

ctgggcaaag taggctatca tgtggcgcga cgggccatcg aggccggcgc tcgagtgatt      600

gcggccgata tcaatccgca tgtagtcggc cgagtggcgt ccgcttgggg gattgaagcc      660

accgatccgt gggctgtggt ggaaaccccc tgcgatattt tcgccccctg tgcgttgggt      720

aacgtcatta cggaacggac cgtgtccgcc ctccaatgtc aggtggtggc cggttcggcc      780

aacaatcagc tggcggatga tcgactggcc gatgatttag ctgcccgcgg cattctctat      840

gcgccggatt ttattgcgaa tgccggcgga ttgattcagg tggcggatga aattcgggga      900

tatcatgaag aacgggtccg tcatcaaata gacgggattt atgacgtcct gctcgagatt      960

tttcggaagg cggacgcctc cggccgatca accgtggcgg ttgcggtaga cgaggcgcgt     1020

cgccgtttgg acaccattca ggccatccac cgcctgtacg gatcatag                  1068


<210>  4
<211>  3939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid encoding enzyme 4

<400>  4
ctgcaggtca acggatcata ttctacacat atataatgca ctccaattga cataatacat       60

aacgtgacat atgatacatt tattaatatt aattgtcaca tttacacttc acatattaaa      120

atactctcgt atgaatgcaa tttgaaacat attttaaatt aattgattga tatatattga      180

acaaaaccta acaaaaatgc accctcttgg ttcacaaaga aactttcttc tatttctcac      240

ttatttctgc tagtgtcttt cctattcaaa gccatcattt ccatcaacct tcacaatacc      300

atgtttaaaa agtcattaaa aatcaatttt ttaaatagaa aaaaacaaga agatggaaat      360

cacttggttg gtactatata tttagttgtt aagtttgact cataccgtgt attgaccaat      420

ataaataaaa tcttatttca aataaattca aaagttcaat aaatatatat tcgttcataa      480

cttataataa aattgattat acatagtcct cccccattca cttttactga tcaattattt      540

ctaaaatata ttattacttt tacttgttat ttttaataaa ttaagaaaat ataatactcc      600

cttcgttttt aaaaaaatac ctagtttgac ttgaaacgga gtttaataaa agaaagaaga      660

cttgttaatc ttgtgattct aaattaaagt tatgtcaaat gtaccaaaat gtcctttaat      720

cttgtggtct taaacatgtc acatgaaaaa ttaaagtgtt tccaaaaaaa gaaaggggtc      780

aatgtcattc ttttttaaac agactaaaaa agaaataaac tcattctttt tgaaacggag      840

agagtaattt tttccacgtt ttactcatta atattaaata ttattctcta gatcatccta      900

taagatctaa tagtggacat caattaatac ctatgtcact tattattatt ttaataattg      960

tatcaagtca aataataaca agtaaaaatg gagtacctac tattaatctt caacaaccac     1020

aatttactag ttttttccta gcaaccccct ctcacatatt tcaccattta ctggtttttt     1080

cctagcaacc ccctctcaca tattttgttt accaaccatc atttgttcct ctatatatac     1140

tcaccacatg atagatacat atatatacca caaccaaaac aaaaggtttt ataagttcac     1200

aacatttttt atatacatac aaataaactc taaccatttt ctcttcacta aaatttcttc     1260

attacaaatc taacaattta cttgatccaa tggcaccatc aattgcacaa aatggacata     1320

ttaatggaga agtagctatg gatttgtgca agaaatcaat caatgatcca ttgaattggg     1380

aaatggctgc tgattcttta agaggcagcc atttggatga agtgaaaaag atggtggatg     1440

aatttagaaa gccaattgtg aaacttgggg gtgaaacttt gtcagttgca caagttgcat     1500

ccattgcaaa tgttgatgac aaaagtaatg gggttaaagt ggaactttct gaaagtgcaa     1560

gggctggtgt gaaagctagt agtgattggg ttatggatag tatgagtaaa ggtacagata     1620

gttatggtgt tactgctgga tttggagcaa catctcatag aagaacaaaa aatggtggtg     1680

ctcttcaaaa agaacttatt aggtaaacaa actatttttt ttcgttatat atactaacaa     1740

tgtaaagaat ttaatatttt tttgttatat atactaacaa tgtaaaaaat ttaatatttt     1800

tttgttatat atactaacaa tgtaaagaat ttaatatttt tttgttatac atagcttatc     1860

gactacttaa gtgctccatt gataaagatt tttttttgtt tttacgcgaa ggggattcgg     1920

atgaattcag ttaaaatgtg atcttaatga attatgatat ttttttgtag gttcttgaat     1980

gctggagttt ttggtaatgg aatagaatca tttcacacat tgccacattc agcaacaagg     2040

gcagctatgc ttgttaggat caacactctg cttcaaggct actctggcat tagatttgag     2100

atcttggaag caatcactaa gttgatcaat agcaacatca ccccgtgttt gcctctccgt     2160

ggcacgatca ctgcctcggg tgatctcgtc cctttgtcct atattgctgg tttgctcact     2220

ggcagaccta attccaaggc tgttggaccc aatggtgaga aacttaatgc tgaggaagct     2280

ttctgcgtgg ctggtattag tggtggattt ttcgagttgc agcctaagga aggacttgca     2340

cttgtgaatg gcacagcagt tggttctgct atggcatcaa tagtcctgtt tgagtccaat     2400

atctttgctg ttatgtctga agttttatca gcgattttta ctgaagtgat gaacggaaag     2460

cccgaattca ctgactattt gacacacaag ttgaagcatc accctggtca gattgaggct     2520

gctgctatta tggaacacat tttggatgga agctcttatg tgaaggtagc tcagaagctc     2580

catgaaatgg atcctcttca aaaaccaaag caagatcgtt atgctctccg aacatctcca     2640

caatggcttg gacctcagat tgaagtcatt cgtgctgcaa ctaagatgat cgagagggag     2700

attaactcag tgaacgacaa tccattgatc gatgtttcaa gaaacaaggc cttacatggt     2760

ggcaacttcc aaggaacccc tattggtgtc tccatggata atacaagatt ggcccttgca     2820

tcaattggta aattgatgtt tgcccaattc tcagagcttg tcaacgacta ttacaacaac     2880

gggttgccat ctaatctgac agcaggaagg aatccaagct tggactatgg tttcaagggc     2940

gctgaaatcg cgatggcttc ttactgctcg gaacttcaat tcttggcaaa tccagtgact     3000

aaccatgtct aaagtgctga gcaacacaac caagatgtga attccttggg cttaatttca     3060

gccaggaaaa cagctaaggc tgttgatatc ttgaagataa tgtcatcaac ctatctcgtg     3120

gctctttgcc aagctattga cttacgacat ttggaggaaa acttgaagag tgttgtcaag     3180

aacacagtta gccaagtagc taagagaact ttgacaatgg gtgctaatgg tgaacttcat     3240

ccagcaagat tcagcgaaaa agaattgctt cgagtcgtgg atagagaata cttgtttgcc     3300

tatgctgatg atccctgcag ctccaactac cctttgatgc agaagctgag acaagtcctt     3360

gttgatcaag caatgaagaa tggtgaaagt gagaagaatg tcaacagctc aatcttccaa     3420

aagattggag ctttcgagga cgaattaatc gctgtgttgc ctaaagaagt tgagagtgta     3480

agagctgttt ttgaaagtgg caacccttta attcgtaaca ggatcacaga atgcagatca     3540

tatccattgt acaggttggt gagagaagaa cttggaacag aattgttgac gggtgaaaaa     3600

gttcgatcac ctggtgagga gattgataaa gtgtttacag caatatgtaa tggacagatt     3660

attgatccat tgttggagtg tctgaagagc tggaatggtg ctcctcttcc aatctgctaa     3720

atgtgttatt ctttcaagtt ctttttttgt accttttagt gaattactag aattataatg     3780

atgttatgaa cttatattaa aaaaaaatat ttttgactat aaaatttagt tttgttattg     3840

aaattaaagg ctcaatctgt gttctttcct tctgttatct gaatattata agaattcaag     3900

taatctttta gctttgtgaa catgatgaca tgctttctt                            3939


<210>  5
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid seqeunce encoding enzyme 5

<400>  5
atgatcacgc ttacccccgg ccacctgacc ctcccgcaac tgcgccagat cgcgcgcgag       60

cccgtgcagc tgacgctgga tccggccagc ttcgcgaaga tcgacgcggg cgcgaaggcc      120

gtgtccgaca tcgccgcgaa gggcgagccg gcgtacggca tcaacacggg cttcggtcgt      180

ctggccagca cgcatatccc gcacgatcag ctcgaattgc tgcagaagaa cctcgtgctg      240

tcgcatgcag tcggtgtcgg cgagccgatg gcgcgttcgt cggtgcgtct gctgatcgcg      300

ctgaagctgt cgagcctcgg ccgcggccat tcgggcattc gccgcgaagt gatggacgcg      360

ctgatcaagc tgttcaacgc cgacgtgctg ccgctgattc cggtgaaggg ctcggtcggc      420

gcatcgggcg acctcgcgcc gctcgcgcac atgtcggccg tgctgctcgg cgtcggcgaa      480

gtgttcattc gcggcgagcg cgcgagcgcg gtggacgggt tgcgcgtcgc gggcctcgcg      540

ccgctgacgc tgcaggcgaa ggaaggcctc gcgctgctga acggtacgca ggcgtcgacg      600

gcgctcgcgc tcgacaacct gttcgcgatc gaagacctgt accgcacggc gctcgtcgcc      660

ggcgcgctgt cggtcgatgc ggcggccggc tcggtgaagc cgttcgacgc gcgcatccac      720

gaactgcgcg gccatcgcgg ccagatcgat gcggcggccg cgtatcgcga gctgctcgaa      780

ggctcggcga tcaacctctc gcatcgcgac tgcggcaagg tgcaggatcc gtacagcctg      840

cgctgccagc cgcaggtgat gggcgcgtgc ctggaccaga tgcgtcatgc ggccgacgtg      900

ctgctcgtcg aggcgaacgc ggtatcggac aacccgctga tcttcccgga taccggcgaa      960

gtgctgtcgg gcggcaattt ccatgcggag cccgtcgcgt tcgcggccga caacctcgcg     1020

ctcgcggctg cggaaatcgg cgcgctggcc gagcgccgca tcgcgctgct gatcgacgcg     1080

acgctgtcgg gcctgccgcc gttcctcgtg aaggatggcg gcgtgaactc gggcttcatg     1140

attgcgcacg tgacggcagc tgcgctcgca tcggagaaca agacgctcgc gcatccggcg     1200

tcggtcgatt cgctgccgac ctcggcgaac caggaagacc acgtgtcgat ggcgacgttc     1260

gcggcacgca agctggccga catcgccgac aacacgaagc acatcctcgc gatcgaactg     1320

ctcgcggccg cgcagggcgt cgatctgcgc gagaacgaga cgagcccgaa gctcgcggaa     1380

gtgatgaaga cgattcgcag caaggtcgcg cattacgagc tcgaccacta ctttgcgccg     1440

gacatcgccg tgatcgcgaa gctcgtcgtc gagcgcgcgt tcgcgaagca ctgcccgttc     1500

gccttcgcat cggagcagta a                                               1521


<210>  6
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding enzyme  6

<400>  6
gtgacgcagg tcgtggaacg tcaggctgat cggctcagca gcagggagta cctggcccgg       60

gtcgtgcgca gcgccgggtg ggacgccggt ctcacctcgt gcaccgacga ggagatcgtc      120

cggatgggcg cgagcgcgcg caccatcgag gagtacctga agtccgacaa gcccatctac      180

ggcctgacgc agggcttcgg tccgctggtg ctgttcgacg ccgactcgga gctggagcag      240

ggcggctcgc tgatctcgca cctgggcacc ggccagggcg cgccactggc cccggaggtg      300

tcgcggctga tcctctggct gcgcatccag aacatgcgca aggggtactc ggcggtctcg      360

ccggtgttct ggcagaagct cgccgacctg tggaacaagg ggttcacccc ggcgatcccc      420

cggcacggca cggtcagcgc gagcggcgac ctgcaaccgc tggcgcacgc cgcgctcgcc      480

ttcaccggtg tcggcgaggc gtggacccgg gacgccgacg gccggtggtc caccgtgccg      540

gccgtggacg cgctcgccgc gctgggggcg gagccgttcg actggccggt gcgcgaggcg      600

ctggcgttcg tcaacgggac cggcgcgagc ctcgcggtgg ctgtgctcaa ccaccggtcc      660

gccctgcggc tggtccgcgc ctgcgccgtg ctctccgcgc ggctggcgac cctgctgggg      720

gccaatcccg agcactacga cgtggggcac ggtgtcgcgc gcggccaggt cggtcagctg      780

accgcggcgg agtggatccg gcaggggctg ccccggggca tggtgcgcga cggcagccgc      840

ccgctccagg agccgtacag cctgcggtgc gcgccgcagg tgctcggcgc ggtgctcgac      900

cagctcgacg gcgcgggcga cgtgctggcg cgggaggtcg acggctgcca ggacaacccg      960

atcacctacg agggcgagct gctgcacggc ggcaacttcc acgccatgcc ggtgggtttc     1020

gcctccgacc agatcgggtt ggccatgcac atggccgcct acctggccga gcgccagctg     1080

ggtctgctgg tcagcccggt gaccaacggc gacctgccgc ccatgctcac cccgcgcgcc     1140

gggcgcggtg ccgggctggc cggggtgcag atcagcgcga cctcgttcgt ctcgcggatc     1200

cggcagctgg tgttccccgc ctcgctgacc accctgccga ccaacggctg gaaccaggac     1260

cacgtgccga tggcgctcaa cggggcgaac tcggtgttcg aggcgttgga gctcggctgg     1320

ctgacggtcg ggtcgctggc ggtgggcgtc gcgcagctcg cggccatgac cggccacgcc     1380

gcggagggcg tctgggcgga gctggccggg atctgcccgc cgctggacgc cgaccgcccg     1440

ctgggcgccg aggtgcgcgc cgcgcgcgac ctgctgtccg cgcacgcgga ccaactgctc     1500

gtcgacgagg cagacgggaa ggatttcgga tga                                  1533


<210>  7
<211>  721
<212>  PRT
<213>  Solanum lycopersicum

<400>  7

Met Ala Ser Ser Ile Val Gln Asn Gly His Val Asn Gly Glu Ala Met 
1               5                   10                  15      


Asp Leu Cys Lys Lys Ser Ile Asn Val Asn Asp Pro Leu Asn Trp Glu 
            20                  25                  30          


Met Ala Ala Glu Ser Leu Arg Gly Ser His Leu Asp Glu Val Lys Lys 
        35                  40                  45              


Met Val Asp Glu Phe Arg Lys Pro Ile Val Lys Leu Gly Gly Glu Thr 
    50                  55                  60                  


Leu Thr Val Ala Gln Val Ala Ser Ile Ala Asn Val Asp Asn Lys Ser 
65                  70                  75                  80  


Asn Gly Val Lys Val Glu Leu Ser Glu Ser Ala Arg Ala Gly Val Lys 
                85                  90                  95      


Ala Ser Ser Asp Trp Val Met Asp Ser Met Gly Lys Gly Thr Asp Ser 
            100                 105                 110         


Tyr Gly Val Thr Thr Gly Phe Gly Ala Thr Ser His Arg Arg Thr Lys 
        115                 120                 125             


Asn Gly Gly Ala Leu Gln Lys Glu Leu Ile Arg Phe Leu Asn Ala Gly 
    130                 135                 140                 


Val Phe Gly Asn Gly Thr Glu Ser Ser His Thr Leu Pro His Ser Ala 
145                 150                 155                 160 


Thr Arg Ala Ala Met Leu Val Arg Ile Asn Thr Leu Leu Gln Gly Tyr 
                165                 170                 175     


Ser Gly Ile Arg Phe Glu Ile Leu Glu Ala Ile Thr Lys Leu Ile Asn 
            180                 185                 190         


Ser Asn Ile Thr Pro Cys Leu Pro Leu Arg Gly Thr Ile Thr Ala Ser 
        195                 200                 205             


Gly Asp Leu Val Pro Leu Ser Tyr Ile Ala Gly Leu Leu Thr Gly Arg 
    210                 215                 220                 


Pro Asn Ser Lys Ala Val Gly Pro Asn Gly Glu Lys Leu Asn Ala Glu 
225                 230                 235                 240 


Glu Ala Phe Arg Val Ala Gly Val Thr Ser Gly Phe Phe Glu Leu Gln 
                245                 250                 255     


Pro Lys Glu Gly Leu Ala Leu Val Asn Gly Thr Ala Val Gly Ser Gly 
            260                 265                 270         


Met Ala Ser Met Val Leu Phe Glu Ser Asn Ile Leu Ala Val Met Ser 
        275                 280                 285             


Glu Val Leu Ser Ala Ile Phe Ala Glu Val Met Asn Gly Lys Pro Glu 
    290                 295                 300                 


Phe Thr Asp Tyr Leu Thr His Lys Leu Lys His His Pro Gly Gln Ile 
305                 310                 315                 320 


Glu Ala Ala Ala Ile Met Glu His Ile Leu Asp Gly Ser Ser Tyr Val 
                325                 330                 335     


Lys Ala Ala Gln Lys Leu His Glu Met Asp Pro Leu Gln Lys Pro Lys 
            340                 345                 350         


Gln Asp Arg Tyr Ala Leu Arg Thr Ser Pro Gln Trp Leu Gly Pro Gln 
        355                 360                 365             


Ile Glu Val Ile Arg Ala Ala Thr Lys Met Ile Glu Arg Glu Ile Asn 
    370                 375                 380                 


Ser Val Asn Asp Asn Pro Leu Ile Asp Val Ser Arg Asn Lys Ala Leu 
385                 390                 395                 400 


His Gly Gly Asn Phe Gln Gly Thr Pro Ile Gly Val Ser Met Asp Asn 
                405                 410                 415     


Thr Arg Leu Ala Leu Ala Ser Ile Gly Lys Leu Met Phe Ala Gln Phe 
            420                 425                 430         


Ser Glu Leu Val Asn Asp Tyr Tyr Asn Asn Gly Leu Pro Ser Asn Leu 
        435                 440                 445             


Thr Ala Gly Arg Asn Pro Ser Leu Asp Tyr Gly Leu Lys Gly Ala Glu 
    450                 455                 460                 


Ile Ala Met Ala Ser Tyr Cys Ser Glu Leu Gln Phe Leu Ala Asn Pro 
465                 470                 475                 480 


Val Thr Asn His Val Gln Ser Ala Glu Gln His Asn Gln Asp Val Asn 
                485                 490                 495     


Ser Leu Gly Leu Ile Ser Ala Arg Lys Thr Ala Glu Ala Val Asp Ile 
            500                 505                 510         


Leu Lys Leu Met Ser Ser Thr Tyr Leu Val Ala Leu Cys Gln Ala Ile 
        515                 520                 525             


Asp Leu Arg His Leu Glu Glu Asn Leu Arg Ser Ala Val Lys Asn Thr 
    530                 535                 540                 


Val Ser Gln Val Ala Lys Arg Thr Leu Thr Met Gly Ala Asn Gly Glu 
545                 550                 555                 560 


Leu His Pro Ala Arg Phe Cys Glu Lys Glu Leu Leu Arg Val Val Asp 
                565                 570                 575     


Arg Glu Tyr Val Phe Ala Tyr Ala Asp Asp Pro Cys Ser Ser Thr Tyr 
            580                 585                 590         


Pro Leu Met Gln Lys Leu Arg Gln Val Leu Val Asp His Ala Met Lys 
        595                 600                 605             


Asn Gly Glu Ser Glu Lys Asn Val Asn Ser Ser Ile Phe Gln Lys Ile 
    610                 615                 620                 


Val Ala Phe Glu Asp Glu Leu Lys Ala Val Leu Pro Lys Glu Val Glu 
625                 630                 635                 640 


Ser Ala Arg Ala Val Val Glu Ser Gly Asn Pro Ala Ile Pro Asn Arg 
                645                 650                 655     


Ile Thr Glu Cys Arg Ser Tyr Pro Leu Tyr Arg Leu Val Arg Gln Glu 
            660                 665                 670         


Leu Gly Ser Glu Leu Leu Thr Gly Glu Lys Val Arg Ser Pro Gly Glu 
        675                 680                 685             


Glu Ile Asp Lys Val Phe Thr Ala Met Cys Asn Gly Gln Ile Ile Asp 
    690                 695                 700                 


Pro Leu Leu Glu Cys Leu Lys Ser Trp Asn Gly Ala Pro Leu Pro Ile 
705                 710                 715                 720 


Cys 
    


<210>  8
<211>  1101
<212>  DNA
<213>  Thermoactinomyces intermedius

<400>  8
atgcgcgacg tgtttgaaat gatggaccgc tatggccacg agcaggtcat tttttgccgt       60

catccgcaaa ccggtctcaa agcgatcatc gccttgcata atacaaccgc ggggccggct      120

ttgggtggat gccgcatgat cccgtatgct tcgacggacg aagccttgga ggatgttttg      180

cggttgtcca aaggcatgac ctataaatgc agtctggcgg atgtggactt tggcggggga      240

aaaatggtta tcatcggcga tccgaaaaaa gataaatcgc cggagttgtt tcgcgtgatc      300

ggccgttttg tgggcgggtt aaacggccgt ttctataccg gaaccgacat gggaaccaat      360

ccggaagatt ttgtccatgc cgccagggaa tcgaaatctt ttgccggatt gccgaaatcg      420

tacggcggaa agggggacac atccattccc accgcgctcg gggtgtttca cggaatgcgg      480

gccaccgccc ggtttttatg ggggacggat cagctgaaag ggcgtgtggt tgccatccaa      540

ggagtcggca aggtgggaga gcgcttgttg cagcttttgg tcgaagtggg ggcttactgc      600

aaaattgccg acatcgattc ggtgcgatgc gaacagctga aagaaaagta tggcgacaag      660

gtccaattgg tggatgtgaa ccggattcac aaggagagtt gcgatatttt ctcgccttgc      720

gccaaaggcg gcgtggtcaa tgatgacacc attgacgagt tccgttgcct ggccattgtc      780

ggatccgcca acaaccaact ggtggaagac cggcatgggg cactgcttca aaaacggagc      840

atttgttatg cacccgatta tctggtgaat gccggcgggc tgattcaagt ggctgatgaa      900

ctggaaggct tccatgaaga gagagtgctc gccaaaaccg aagcgattta tgacatggtc      960

ctggatattt ttcaccgggc gaaaaatgag aatattacca cttgtgaggc agcggaccgg     1020

atcgtgatgg agcgtttgaa aaagttaacc gatattcgcc ggatcttgtt ggaggatccc     1080

cgcaacagcg caaggaggta a                                               1101


<210>  9
<211>  352
<212>  PRT
<213>  Caenorhabditis remanei

<400>  9

Met Asp Phe Lys Ala Lys Leu Leu Ala Glu Met Ala Lys Lys Arg Lys 
1               5                   10                  15      


Ala Val Ser Gly Leu Glu Val Lys Glu Gly Gly Ala Lys Phe Val Arg 
            20                  25                  30          


Gly Ala Asp Leu Glu Ser Lys Arg Thr Gln Glu Tyr Glu Ala Lys Gln 
        35                  40                  45              


Glu Glu Leu Ala Ile Lys Lys Arg Lys Ala Asp Asp Glu Ile Leu Gln 
    50                  55                  60                  


Glu Ser Thr Ser Arg Ala Lys Ile Val Pro Glu Val Pro Glu Ala Glu 
65                  70                  75                  80  


Phe Asp Glu Lys Thr Pro Met Pro Glu Ile His Ala Arg Leu Arg Gln 
                85                  90                  95      


Arg Gly Gln Pro Ile Leu Leu Phe Gly Glu Ser Glu Leu Ser Val Arg 
            100                 105                 110         


Lys Arg Leu His Gln Leu Glu Ile Glu Gln Pro Glu Leu Asn Glu Gly 
        115                 120                 125             


Trp Glu Asn Glu Met Gln Thr Ala Met Lys Phe Ile Gly Lys Glu Met 
    130                 135                 140                 


Asp Lys Ala Val Val Glu Gly Thr Ala Asp Ser Ala Thr Arg His Asp 
145                 150                 155                 160 


Ile Ala Leu Pro Gln Gly Tyr Glu Glu Asp Asn Trp Lys Ser Ile Glu 
                165                 170                 175     


His Ala Ser Thr Leu Leu Gly Val Gly Asp Glu Met Lys Arg Asp Cys 
            180                 185                 190         


Asp Ile Ile Leu Ser Ile Cys Arg Tyr Ile Leu Ala Arg Trp Ala Arg 
        195                 200                 205             


Asp Leu Asn Asp Arg Pro Leu Asp Val Lys Lys Thr Ala Gln Gly Met 
    210                 215                 220                 


His Glu Ala Ala His His Lys Gln Thr Thr Met His Leu Lys Ser Leu 
225                 230                 235                 240 


Met Thr Ser Met Glu Lys Tyr Asn Val Asn Asn Asp Ile Arg His His 
                245                 250                 255     


Leu Ala Lys Ile Cys Arg Leu Leu Val Ile Glu Arg Asn Tyr Leu Glu 
            260                 265                 270         


Ala Asn Asn Ala Tyr Met Glu Met Ala Ile Gly Asn Ala Pro Trp Pro 
        275                 280                 285             


Val Gly Val Thr Arg Ser Gly Ile His Gln Arg Pro Gly Ser Ala Lys 
    290                 295                 300                 


Ala Tyr Val Ser Asn Ile Ala His Val Leu Asn Asp Glu Thr Gln Arg 
305                 310                 315                 320 


Lys Tyr Ile Gln Ala Phe Lys Arg Leu Met Thr Lys Leu Gln Glu Tyr 
                325                 330                 335     


Phe Pro Thr Asp Pro Ser Lys Ser Val Glu Phe Val Lys Lys Ser Val 
            340                 345                 350         


<210>  10
<211>  411
<212>  PRT
<213>  Arabidopsis thaliana

<400>  10

Met Asn Ala Leu Ala Ala Thr Asn Arg Asn Phe Lys Leu Ala Ala Arg 
1               5                   10                  15      


Leu Leu Gly Leu Asp Ser Lys Leu Glu Lys Ser Leu Leu Ile Pro Phe 
            20                  25                  30          


Arg Glu Ile Lys Val Glu Cys Thr Ile Pro Lys Asp Asp Gly Thr Leu 
        35                  40                  45              


Ala Ser Phe Val Gly Phe Arg Val Gln His Asp Asn Ala Arg Gly Pro 
    50                  55                  60                  


Met Lys Gly Gly Ile Arg Tyr His Pro Glu Val Asp Pro Asp Glu Val 
65                  70                  75                  80  


Asn Ala Leu Ala Gln Leu Met Thr Trp Lys Thr Ala Val Ala Lys Ile 
                85                  90                  95      


Pro Tyr Gly Gly Ala Lys Gly Gly Ile Gly Cys Asp Pro Ser Lys Leu 
            100                 105                 110         


Ser Ile Ser Glu Leu Glu Arg Leu Thr Arg Val Phe Thr Gln Lys Ile 
        115                 120                 125             


His Asp Leu Ile Gly Ile His Thr Asp Val Pro Ala Pro Asp Met Gly 
    130                 135                 140                 


Thr Gly Pro Gln Thr Met Ala Trp Ile Leu Asp Glu Tyr Ser Lys Phe 
145                 150                 155                 160 


His Gly Tyr Ser Pro Ala Val Val Thr Gly Lys Pro Ile Asp Leu Gly 
                165                 170                 175     


Gly Ser Leu Gly Arg Asp Ala Ala Thr Gly Arg Gly Val Met Phe Gly 
            180                 185                 190         


Thr Glu Ala Leu Leu Asn Glu His Gly Lys Thr Ile Ser Gly Gln Arg 
        195                 200                 205             


Phe Val Ile Gln Gly Phe Gly Asn Val Gly Ser Trp Ala Ala Lys Leu 
    210                 215                 220                 


Ile Ser Glu Lys Gly Gly Lys Ile Val Ala Val Ser Asp Ile Thr Gly 
225                 230                 235                 240 


Ala Ile Lys Asn Lys Asp Gly Ile Asp Ile Pro Ala Leu Leu Lys His 
                245                 250                 255     


Thr Lys Glu His Arg Gly Val Lys Gly Phe Asp Gly Ala Asp Pro Ile 
            260                 265                 270         


Asp Pro Asn Ser Ile Leu Val Glu Asp Cys Asp Ile Leu Val Pro Ala 
        275                 280                 285             


Ala Leu Gly Gly Val Ile Asn Arg Glu Asn Ala Asn Glu Ile Lys Ala 
    290                 295                 300                 


Lys Phe Ile Ile Glu Ala Ala Asn His Pro Thr Asp Pro Asp Ala Asp 
305                 310                 315                 320 


Glu Ile Leu Ser Lys Lys Gly Val Val Ile Leu Pro Asp Ile Tyr Ala 
                325                 330                 335     


Asn Ser Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Val Gln Asn Ile 
            340                 345                 350         


Gln Gly Phe Met Trp Glu Glu Glu Lys Val Asn Asp Glu Leu Lys Thr 
        355                 360                 365             


Tyr Met Thr Arg Ser Phe Lys Asp Leu Lys Glu Met Cys Lys Thr His 
    370                 375                 380                 


Ser Cys Asp Leu Arg Met Gly Ala Phe Thr Leu Gly Val Asn Arg Val 
385                 390                 395                 400 


Ala Gln Ala Thr Ile Leu Arg Gly Trp Gly Ala 
                405                 410     


<210>  11
<211>  1275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding enzyme 11

<400>  11
atgtcagcaa agcaagtctc gaaagatgaa gaaaaagaag ctcttaactt atttctgtct       60

acccaaacaa tcattaagga agcccttcgg aagctgggtt atccgggaga tatgtatgaa      120

ctcatgaaag agccgcagag aatgctcact gtccgcattc cggtcaaaat ggacaatggg      180

agcgtcaaag tgttcacagg ctaccggtca cagcacaatg atgctgtcgg tccgacaaag      240

gggggcgttc gcttccatcc agaagttaat gaagaggaag taaaggcatt atccatttgg      300

atgacgctca aatgcgggat tgccaatctt ccttacggcg gcgggaaggg cggtattatt      360

tgtgatccgc ggacaatgtc atttggagaa ctggaaaggc tgagcagggg gtatgtccgt      420

gccatcagcc agatcgtcgg tccgacaaag gatattccag ctcccgatgt gtacaccaat      480

tcgcagatta tggcgtggat gatggatgag tacagccggc tgcgggaatt cgattctccg      540

ggctttatta caggtaaacc gcttgttttg ggaggatcgc aaggacggga aacagcgacg      600

gcacagggcg tcacgatttg tattgaagag gcggtgaaga aaaaagggat caagctgcaa      660

aacgcgcgca tcatcataca gggctttgga aacgcgggta gcttcctggc caaattcatg      720

cacgatgcgg gcgcgaaggt gatcgggatt tctgatgcca atggcgggct ctacaaccca      780

gacggccttg atatccctta tttgctcgat aaacgggaca gctttggtat ggtcaccaat      840

ttatttactg acgtcatcac aaatgaggag ctgcttgaaa aggattgcga tattttagtg      900

cctgccgcga tctccaatca aatcacagcc aaaaacgcac ataacattca ggcgtcaatc      960

gtcgttgaag cggcgaacgg cccgacaacc attgatgcca ctaagatcct gaatgaaaga     1020

ggcgtgctgc ttgtgccgga tatcctagcg agtgccggcg gcgtcacggt ttcttatttt     1080

gaatgggtgc aaaacaacca aggatattat tggtcggaag aagaggttgc agaaaaactg     1140

agaagcgtca tggtcagctc gttcgaaaca atttatcaaa cagcggcaac acataaagtg     1200

gatatgcgtt tggcggctta catgacgggc atcagaaaat cggcagaagc atcgcgtttc     1260

cgcggatggg tctaa                                                      1275


<210>  12
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding enzyme 12

<400>  12
atgtccatca aagacgctgt aaaactgatt gaagaaagcg aagcccgctt tgtcgatttg       60

cgctttaccg ataccaaagg caagcagcac cactttaccg tgcctgcgcg catcgtgttg      120

gaagaccccg aagagtggtt cgaaaacgga caggcgtttg acggttcgtc catcggcggc      180

tggaaaggca ttcaggcttc cgatatgcag cttcgccccg atcccgccac ggcgtttatc      240

gatccttttt atgatgatgt taccgtcgtc attacctgcg acgttatcga tcccgccgac      300

ggtcagggtt acgaccgcga cccgcgctcc atcgcacgcc gcgccgaagc ctatttgaaa      360

tcttccggta tcggcgacac ggcatacttc ggtcccgaac ccgagttttt cgtcttcgac      420

ggcgtagaat ttgaaaccga tatgcacaaa acccgttacg aaatcacgtc cgaaagcggc      480

gcatgggcca gcggcctgca tatggacggt caaaacaccg gccaccgccc tgccgtcaaa      540

ggcggttacg cgcccgtcgc gccgattgac tgcggtcagg atttgcgttc cgcgatggta      600

aacattttgg aaggactcgg catcgaagtc gaagtgcacc acagcgaagt cggtaccggc      660

agccaaatgg aaatcggcac gcgcttcgcc accttggtca aacgcgccga ccaaacccaa      720

gacatgaaat atgtgattca aaatgtcgcc cacaacttcg gcaaaaccgc caccttcatg      780

cccaaaccca ttatgggcga caacggcagc ggtatgcacg ttcaccaatc catctggaaa      840

gacggtcaaa acctgttcgc aggcgacggc tatgccggct tgagcgacac cgcgctctac      900

tacatcggcg gcatcatcaa acacgccaaa gccctgaacg cgattaccaa tccgtccacc      960

aactcctaca aacgccttgt gccgcacttt gaagcgccga ccaaactggc atattccgcc     1020

aaaaaccgtt ccgcttccat ccgtattccg tctgtgaaca gcagcaaggc gcgccgcatc     1080

gaagcgcgtt tccccgaccc gaccgccaac ccgtacttgg cgttcgctgc cctgctgatg     1140

gcgggtttgg acggcattca aaacaaaatc catccgggcg atcctgccga taaaaatctc     1200

tacgacctgc cgccggaaga agacgcgctc gtcccgaccg tttgcgcttc tttagaagaa     1260

gccctcgccg cgctcaaagc cgaccacgaa ttcctcttac gcggcggcgt gttcagcaaa     1320

gactggatcg acagctacat cgcctttaaa gaggaagatg tccgccgcat ccgtatggcg     1380

ccgcatccgc tggaatttga aatgtattac agcctgtaa                            1419


<210>  13
<211>  1075
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding enzyme 13

<400>  13
aggaggtgtt ttaataatga aaggttttgc aatgctcagt atcggtaaag tcggttggat       60

tgaaaaagaa aagcctactc ccggcccttt tgacgctatt gtaagacctc tagctgtggc      120

cccttgcact tcggacgttc ataccgtttt tgaaggtgct attggcgaaa gacataacat      180

gatactcggt cacgaagctg taggtgaagt agttgaagta ggtagtgagg taaaagattt      240

taaacctggt gatcgcgttg tggtaccagc tattacccct gattggcgaa cctctgaagt      300

gcaaagagga tatcaccaac actctggtgg aatgctggca ggctggaaat tttcgaatat      360

aaaagatggt gtttttggtg aattttttca tgtgaacgat gctgatatga atttagcaca      420

tctgcctaag gaaattccat tggaagctgc agttatgatt cccgatatga tgactactgg      480

ctttcacgga gccgaactgg cagatataga attaggtgcg acggtagcgg ttttgggtat      540

tggcccagta ggtcttatgg cagtcgctgg tgccaaattg cggggtgctg gaaggattat      600

cgcagtaggc agtagaccag tttgtgtaga tgctgcaaaa tactatggag ctactgatat      660

tgtaaactat aaagatggtc ctatcgacag tcagattatg gatttaacgg aaggcaaagg      720

tgttgatgct gccatcatcg ctggaggaaa tgttgacatc atggctacag cagttaagat      780

tgttaaacct ggtggcacca tcgctaatgt aaattacttt ggcgaaggag atgttttgcc      840

tgttcctcgt cttgaatggg gttgcggcat ggctcataaa actataaaag gcgggctatg      900

ccccggtgga cgtctaagaa tggaaagact gattgacctt gttgtttata agcgtgtcga      960

tccttctaag ctcgtcactc acgttttccg gggatttgac aatattgaaa aagcctttat     1020

gttgatgaaa gacaaaccaa aagacctaat caaacctgtt gtaatattag cataa          1075


<210>  14
<211>  1545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 14

<400>  14
atggctgact cgcaacccct gtccggtacc ccggaaggtg ccgaatattt aagagcggtg       60

ctgcgcgcgc cggtctacga agcggcgcag gtcacgccgc tacagaaaat ggaaaaactg      120

tcgtcgcgtc tcgataacgt gattctggtg aagcgcgaag atcgccagcc agttcatagc      180

tttaagttgc gcggcgcata cgccatgatg gcgggcctga cggaagaaca aaaagcacac      240

ggcgtgatta ccgcttctgc aggtaaccac gcgcagggcg tcgcgttttc ttccgcacgg      300

ttaggcgtga aggcgctgat cgtcatgcca accgccaccg ccgatatcaa agttgatgcg      360

gtgcgcggct ttggcggcga agtgctgctt cacggcgcaa atttcgatga agcgaaagcg      420

aaagcgatcg aactgtcaca gcagcagggt ttcacctggg taccgccgtt cgatcatccg      480

atggtgatcg ccgggcaagg cacgctggcg ctggaactgc tccagcagga cgcccatctc      540

gaccgcgtat ttgtaccggt cggcggcggc ggtctggcag cgggtgtggc ggtgctgatc      600

aaacaactga tgccgcaaat caaagtaatc gccgtggaag cggaagattc cgcctgcctg      660

aaagcggcgc tggatgcggg tcatcccgtt gatctgcccc gcgtggggct gtttgctgaa      720

ggcgtcgcgg taaaacgcat cggcgatgaa accttccgtt tgtgccagga gtatcttgac      780

gacatcatca ccgtcgatag cgatgccatc tgtgcggcga tgaaagatct gttcgaagat      840

gtgcgcgcgg tggcggaacc ttccggcgcg ctggcgctgg cggggatgaa aaaatacatc      900

gcccagcaca acattcgcgg tgaacggctg gcgcatattc tttccggtgc taacgtgaac      960

tttcacggtc tgcgctacgt ctcggaacgc tgcgaactgg gcgaacagcg tgaagcgttg     1020

ttggcggtga ccattccgga agaaaaaggc agcttcctca aattctgcca actgcttggc     1080

gggcgttcgg tcaccgagtt caactaccgt tttgccgatg ccaaaaacgc ctgcatcttt     1140

gtcggcgtgc gcttaagccg tggcctcgaa gagcgcaaag aaattttgca gatgctcaac     1200

gacggtggct acagcgtggt tgatctctcc gacgacgaaa tggcgaagct gcatgtgcgc     1260

tatatggttg gcgggcgtcc atcgcatccg ttgcaggaac gcctatacag cttcgaattc     1320

ccggaatcac cgggcgcgct gctgcgcttc ctcaacacgc tgggtacgca ctggaacatc     1380

tcgctgttcc attatcgcag ccacggtacc gactacgggc gcgtactggc ggcgttcgag     1440

cttggcgatc atgaaccgga ttttgaaacc cggttgaatg aactgggcta cgattgccac     1500

gacgaaacca ataacccggc gttcaggttc tttttggcgg gttag                     1545


<210>  15
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding enzyme 15

<400>  15
atgagcggta ccatcctcat caccggcgcc acgtccggct tcggacaggc cacggcgcgg       60

cgtttcgtca aggaaggctg gaaggtcatc ggcacaggtc ggcgggcgga acggctggag      120

gcgctggcgc aagaactcgg ctccgccttt cacggcgctg ccttcgatgt taccgacgaa      180

gatgccacta gaaaggcact tgcggctttg ccggaaggtt tccgggacat cgatattctc      240

gtcaacaatg cggggcttgc gctcggcacc gcacctgcac cgcaggtgcc gctgaaagac      300

tggcagacca tggtgaacac caacatcacc ggtcttttga acatcaccca ccatcttttg      360

cccacgttga tcgaccgcaa gggcattgtc atcaaccttt cctcggtagc tgcgcactgg      420

ccctatgcgg gcggcaatgt ctatgccgga acgaaagcct tcctgcggca attctcgctc      480

ggtctgcgct ccgacctgca tggcaagggc gtgcgcgtca cctcgatcga accgggcatg      540

tgcgaaacgg aattcacgct tgttcgcacc ggcggcaatc aggatgcctc ggacaatctt      600

tacaagggcg tcaatccgat cacggccgag gatatcgcca atacgatcca ttgggtcgcc      660

tcgcagccca aacatatcaa catcaacagc ctcgaactca tgccggtcaa ccagtccttt      720

gccggtttcc aagtgcatcg ggaaagttga                                       750


<210>  16
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 16

<400>  16
atgatgacca aaaacgaaat ccaaaagtgg gtaaaggaat tcccgctgct tgaaacgatc       60

atggcggccg aagaggtatt ttggcgcaat ccaaaatatc acgcgtttgc gcaagctatt      120

cgaacgattc ctttacgcga acgcgatgtc aaggaggccg aagagcgatt gcgccgcttt      180

gccccctaca tcgcgaaagt gtttcccgag acgcgaacgg cccacggtat catcgaatcc      240

cctttagtgc ggattccgaa catgaaacag cgtttggaaa agatgtttca gaccaacatc      300

gagggggatc tgttgctaaa atgcgacagc catcttccca tctccggatc gatcaaggcg      360

agagggggaa tctacgaggt tctgaaacat gcggaagaac tcgctctggc aaaccatatg      420

atcaccatgg gggatgacta tgcggtcatg gccagcgaag aattccggca gttcttttcc      480

cgctattcgc ttgtcgttgg ttcgacggga aatttaggct tgagtatcgg catcatcggg      540

gcgcagcttg ggttccgcgt taccgttcat atgtcagccg atgcgaaaca atggaaaaaa      600

gacttgttgc gaagcaaagg ggttgcggtc atcgaacatc tcaccgacta caacaaggtg      660

gtggaagagg cgcgaagaca gtccgccgag gatccaacgt cgtattttat cgatgatgag      720

aactcgatcc atctgttttt aggctatgcg gtggcggcgt ttcggctgaa aaagcaatta      780

gaggacatga acatcacggt tgatgaaaac cacccgctct ttgtatatct tccttgcggc      840

gtcggcggcg gtccgggcgg ggtgacgttt gggctgaagc tcgtgtacgg cgatcatgtc      900

cattgctttt tcgctgagcc gacgcattcg ccttgcatgt tgctcggcct gatgacggga      960

cagcacgacc gcgtgtcggt gcaagatttt ggcctcgaca ataagaccga agcggacggg     1020

ctagcggtgg ggcggccgtc aaggttggtg gggaacatgc ttgagaacgt catcagcggc     1080

gtctatacgg tggacgatgc gacgctttac cgcttgctcg cggcgatggt ggaaacggag     1140

gaaatctatt tagagccgtc cgccttggcg ggggtggcgg ggcctgttcg gctgtttcgt     1200

gatttggcgg ggcaaacgta cgtagaggca aacggtttga aagaaaagat gaaaaacgcc     1260

gtccatattg gctgggcgac aggcggaagc atggtgctaa aggatgtgat ggaggcctat     1320

tatcgggaag gcgtgcgcat cgaaacgatg acagggaacg gtttttctga aggacgataa     1380


<210>  17
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 17

<400>  17
atgctgatgt tcgaagaaat ccaggcgcgc ggccacgaga gcgtcacgct gctgcaccac       60

gcccccagcg gcctgcgcgc cgtgctcgcc gtgcactcca ccgtgctcgg ccctgccatt      120

gccggctgcc gcctgatgcc ctgcaccgag gaacgcgccg tgcgcgacgc cctcgccctc      180

agcgagtccg tcacgctcaa ggccgccctc gcgggcctga actacggcgg gggcgcgtgc      240

gtcatgctcc ccccggaagg cggcgacatc gacgggcacg cccgcgaggc gctgttccgc      300

gcgctcggcc ggcagatccg ttaccgcggt ggccgcgtca tcctcaccga ggacgtcggc      360

gtgaccggcc gcgacatcgc cttcgccgcg caggaaaccg acagcaccat gggcatgcac      420

accgacacgc ccaccgtcac cgcgtacggc gtgtaccgcg gcatcaaggc cgccgcgcgc      480

gcctacctcg gcggcgagag catgcgcggc gtgcgcgtcg cgctgctcgg cgcgggcgca      540

gtcgggcgca ccctcgcgca gcacctgcac cgcgagggcg cgcgcctcac cgtcgcagac      600

ctgatgtctg agcgcgcgca ggccctcgcg gacgacctcg gcgagcgcgt caccgtcgtg      660

agcgccgctg acatcttcga cgtgccgtgc gacgtattcg cgccgtgcgc gttcgggcac      720

agcatcaaaa gcgccgacgt gccccgcttg cagtgccggg tgatcgccgg cagcgaacac      780

cacccgctca gccacaacgg cgagacgctc gtgcgcgaag cgggcatcac atacatcccg      840

gacttcgcca tcaacagcgc cggcctgatg agcgccgcgc agaacctcag catcgaaacg      900

gcggcggaac gcgtgtacga gagcgtcgcg cagatctgcg cgaccgcgca gaagtacgag      960

aagccgccgc acgtcgtcgc ccgtaaactc gcgctgcgcc gcatcgaact gatcggctcc     1020

atcagcggcc agtacgccgg ccagtaa                                         1047


<210>  18
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 18

<400>  18
tcatgtgcca acacgtatgt tatcacttaa aatttttagt aaagtgactg ctgaatatgc       60

tgccaaaaca cttgtttttg gatttaattc acacacagtg ttttttgtta tagatttaaa      120

ctctccaaaa tctcctttaa catggacttc atggatattg tgttcaactt caggatctgc      180

aattatcttt acatccgcat ctattccaga ggctagactt aatgccgcag caacgttaat      240

attcactgga aattttttaa cagcttctga ggatttccct ttaaacacga cctccttttt      300

tttggtctta acacctaacg aagtaggtga ttttctcgtt ataagtttta tttcttttat      360

cttacctaag gatgcggctt ttacaccatc taaaccaatt attgcaccgg aaggtatgta      420

tatattagct cctgattctc tagattcctt tatcaatctt cttctaactt tctcatctaa      480

tagtgcaccc acactcataa tcaaaacatc tatacctcta ctaattatat tgggcacaat      540

ttcttttact gcctcttgag aagcagattc aattatcaaa tcaactccat tgaacatttc      600

ttctaccttt tttacggcag tgccatttgt taaatttgct agcttcttag cttttctaaa      660

atttctgtca taaaaatatt ttaattttat ttttttgata tcttgtttta agacaaggtt      720

aactattgta tttgcaattg caccacatcc tataatccca catctcat                   768


<210>  19
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 19

<400>  19
atgtcctcgc ctgcatcatc gcgcatcgaa aaagacctgc ttggtgttct cgaagtacct       60

gccaacgcgt attacggcat ccagaccctg cgagcggtga acaactttca cctctccggc      120

gtgccgcttt cgcactaccc gaaactggta gtcgcgctgg ccatggtcaa gcaggcggca      180

gcggatgcaa accatcagct cggacacctc aatgacgcca agcatgcggc gatcagcgag      240

gcctgtgccc gcctgatccg cggcgacttc cacgatcagt tcgtggtcga catgatccag      300

ggcggcgctg gcacgtcgac caacatgaat gccaacgaag tcatcgccaa catcgctctg      360

gaaaccatgg gtttcgagaa aggcgcatac aaacacctgc accccaacaa cgatgtcaac      420

atggcgcagt cgaccaacga cgcctacccc acggcgatcc gcttgggtct gctgctgggt      480

cacgacgctc tgctcgccag cctttccagc ctgattcagg ccttcgccgc caagggcgaa      540

gaattcaacc atgtgctgaa gatgggccgc acccagttgc aggacgccgt tccaatgacc      600

ctgggtcagg aattccgcgc cttcgccacc accctgacag aagacctgaa ccgcctgcgc      660

agcctggcgc cagagctgtt gaccgaagtg aacctcggcg gaaccgccat cggcaccggc      720

atcaacgccg accctggcta tcagaagctg gcagtcgatc gtctggcact catcagcggc      780

cagcctctgg tgccagcagc cgacctgatc gaagcgacct ccgacatggg cgccttcgtg      840

ttgttctcgg gcatgctcaa gcgtactgcg gtcaagctgt cgaaaatctg caacgacctg      900

cgcctgctgt ccagcggccc acgcaccggc atcaacgaaa tcaacctgcc ggcacgtcag      960

ccaggcagct cgatcatgcc cggcaaggtc aacccggtga tcccggaagc ggtcaatcag     1020

gttgccttcg aaatcatcgg caacgacctg tcgctgacca tggcagccga aggaggacaa     1080

ttgcagctca acgtgatgga gccgctgatc gcctacaaga tcttcgactc gatccgcctg     1140

ctgcagcgcg ccatggacat gctgcgcgag cactgcatcg tcggcatcac agccaacgaa     1200

cagcgctgcc gcgagctggt cgagcattcg atcggtctgg tcaccgccct gaacccttac     1260

atcggttacg agaactccac ccgtatcgcc cgcatcgcgc tggaaaccgg ccgcggcgtg     1320

ctggaactgg tgcgtgagga aggtctgctc gacgacgcca tgctcgacga catcctgcgc     1380

ccggaaaaca tgatcgctcc gcgtctggcc cccttgaagg cctga                     1425


<210>  20
<211>  1083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 20

<400>  20
tcagcgaccg cgggcctcgg ccatccgctg ctcggcgatc cggtcggccg ccgcggcggg       60

cggaatgccg tccgccttcg cacgtgcgaa tatttccagc gtggtgtcga agatcttcgt      120

cgccttcgcc ttgcaccggt cgaagtcgaa cccgtgcagc tcgtcggcga cctggatcac      180

gccgccggcg ttgaccacat agtcgggtgc gtagaggacc gaccggtcgg ccaggtcctt      240

ctcgacaccc gggtgggcca gctggttgtt ggccgcgccg cacaccacct tcgccgtgag      300

caccggaacg gtcgcgtcgt tgagcgcgcc gccgagcgcg cagggcgcgt agatgtcgag      360

accctcggtg cggatcagcg tctcggtgtc cgccaccacg gtgacctcgg ggtgcagatc      420

ggtgatccgg cgcaccgact cctcgcgtac gtcggtgatc acgacctcgg ccccgtcgga      480

gagcaggtgc tcgacgaggt ggtggcccac cttgccgacc ccggcgacgc cgaccttgcg      540

gccgcgcagc gtcgggtcgc cccacaggtg ctgggccgag gcccgcatgc cctggaagac      600

accgaacgcg gtgaggacgg aggagtcgcc ggcgccgccg ttctcggggg agcggccggt      660

ggtccagcgg cactccctgg cgacgacgtc catgtcggcg acgtaggtgc cgacatcgca      720

ggcggtgacg taccggccgc cgagcgaggc gacgaaccgg ccgtaggcca ggaggagttc      780

ctccgtcttg atcttctccg ggtcgccgat gatgacggcc ttgccgccac cgtggtcgag      840

tccggccagg gcgttcttgt acgacatccc gcgcgacagg ttcagcgcgt cggcgacggc      900

ctcggcctcg gtcgcgtacg ggtagaagcg ggtgccgccg aggccggggc ccagggcggt      960

ggagtggagg gcgatgacgg ccttgaggcc ggtggcacgg tcctggcaga tcacgacttg     1020

ctcgtgaccc ccctgatccg agtggaacag ggtgtgcagg acgccgttag tcacatcggt     1080

cac                                                                   1083


<210>  21
<211>  2910
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 21

<400>  21
ctagttgtaa aagtcgaggg aggcgcaact gcacatgagg tgacgatctc cgtaaacccc       60

gtcaatgcga cccacagtcg gccagtactt ttcaacgtac gagtaaggat aagggaatgc      120

cgccaaacgc cgatcatatg gtttgtccca tttatcatcg gtgacacatc ttgccgtgtg      180

tggtgcattc ttcaaaacat tgttatccac tggttgttca cctttttcaa tggcggcaat      240

ctcacctcga atggaaatta gtgcatctgc caagcgatcc aactcccgct tgggttctga      300

ttcggtgggt tcaatcatta aagtcccggg tacaggaaac gccagtgttg gcgagtgaat      360

tccgtagtcc atcaaccgtt tggccacgtc ctccgcctca atatgagctg tcttcttgaa      420

ccgtcgaaga tcaacgataa actcatgagc gcagtagttt tctccaccca ggaaaagaat      480

cgtataatgg ttctctaggc gcttcttcaa gtagtttgca ttcaaaacgg cgtactctgt      540

acaagttttg agcccgtgtg atccaagcat taacatcaac atgtacgata tcggaagaat      600

tgatgctgat ccgtacgctg attgtgagac ttggccgaat ggctgtgaac cgccaacttt      660

ttggttgaaa acagaatttg gcaaaaaggg ggccagatgt tgacggacag ctatagggcc      720

cattccgggg ccgccaccac catggggaat tgaaaacgtc ttgtggagat taatgtggca      780

cacgtcgcca ccgatatatc cagggcctgt atagccaacc atggcgttaa gatttgcccc      840

atcaatgtag cattgtccac cgtagtagtg cgccattgat gtaatggata aaatatcctt      900

gtcaaacaag ccatacgtac ttggatatgt tatcatgata cacgacaact cctttgcgtg      960

tttttggcaa gatttctcca ggtcattgat atcaaccctg ccgttagaca agcatttcac     1020

caagacaata ttcattcctg ccaatgttgc cgaagctgga ttcgtaccat gcgcactctc     1080

tggaatcaaa cagacgttgc ggtgtccttc cttcattgat agatggtacg cacgaataac     1140

acgaagccca gcgtattcac cttgggcgcc actattaggc tgaagcgata ccgcatccag     1200

accggtaatt tcccttaact tttgctcaag atctagacac aacgcactgt accctcgcac     1260

ttggtccact ggggcaaggg gatgcacatt ggtgaattct ggccaagaga gtggtaacat     1320

agcagcggca gggttaagct tcatggtgca agatcccaac gggacgcaac catgcgtaag     1380

gccgtaatcc tttcgttgta gacgatgaat atagcgcatc agttcacttt cactcttgta     1440

cttttgaaac gttgagtgtt tcaggaaatc agacttccgc accagatcca acggtagtac     1500

cgatttctga tcggctattt tggaaagggc tgcgacgacg ggaagcttca accctgcagc     1560

ctccaaaagt gacacaatgt gtccatccgt tgttgcctca tccacagaaa tggagacagt     1620

cccattactg taatcaacaa aaacattaat acccttctca acacatcgtg tcttgtaatc     1680

ctccgctgta atgcctttta ggttcacagt aacagtgtcg aaaaatgcac tgtttaccac     1740

agagtgtcct actgattcca taccaacagc gagcactttc gccttgccgt gtatctcatt     1800

ggcaatctca tttagaccat ctggaccatg gtaggcggca taaaacccac tcacgttggc     1860

caataacgct tgtgcagtac agatatttga tgtggcgcgc tcacgcttaa tatgttgttc     1920

acgtgtctgc agcgccatgc gtatggatgg ctctccggca gaatccttac tgacgccgat     1980

cacacgtccc ggcatcaacc tcttaaactg ctccttgaca gcaaagaacg cggcgtgagg     2040

acctccatat cctagtggaa caccaaaacg ctgggaggat cccacaacca catctgcatt     2100

catttcacca ggtggcttga caagaacaca agccatcaag tcggtcccac agcaactaat     2160

gacaccgtgc ttctttgcat tctcgaacag tggtgagaag tcatgaagca tgcccatcgc     2220

atctggtgtt tgtacaagga taccaaacaa ggaactgtca gtccagtcaa tcagattcgt     2280

gtcgcccacg acgacgttta tcttgagcgg ttcggctctt gtcttaacca tctcaatgca     2340

ggatggaaaa acagtttttg atacgaagaa cgtattccgc tttcgttgac catgctgaaa     2400

agcaagatgc atcgcctcgg atgatgctgt cgcttggtca agaagagatg catttgccac     2460

atccatcttt gtcaaatcca taaccatggt ttggaaattc aaaagggact ccagacgtcc     2520

ttgtgcaatc tcagcttggt atggtgtgta gggtgtgtac catccaggat tttcaatgac     2580

gttgcgaagt atgacaggag gagtaatgga ctcgtagtac ccctgaccaa tcatgctttt     2640

tagtaccttg tttcgcgcac caagagagcg cacgagtgcg agagcatcca tctcactcat     2700

agccgccacc tccgtcaagg gtgggcgtac aatatcccct ggaatagcag ccgtcatcaa     2760

atcagagaga ctctcttttc caaccgttcg aagcatcgac attgtctcag ccgttgttgg     2820

accaatatgg cggttaatat agctgtccgt ggcagtccat cgaacaaatg tcacgcatgg     2880

caaagagcca cgaaacaaac gacggtacat                                      2910


<210>  22
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 22

<400>  22
atgatcattg gcctgccgaa agagatcaaa gttaaggaaa accgcgtggc actcacgccc       60

gggggcgtcg ccagcctcgt gcgccgcggc cacaccgtca tcgtggaacg cagcgccggc      120

gtgggcagcg gcatccagga caccgagtac gagcaggccg gcgcgcagct cggcagcgcc      180

gccgaggcgt gggccgcgca gatggtcgtg aaggtcaagg agcccatcaa gagcgaatac      240

gggtacctcc gcccggacct gctgctgttc acgtacctgc acctcgctgc ggaccagccc      300

ctcacggacg ccctgctgag cgccggcacg accgccgttg cgtacgagac ggtgcagctc      360

gacgaccgca gcctgccgct gctcacgccc atgagtgagg tcgcgggccg cctgagcgtg      420

caggccggcg cgtaccacct gcaaaagccc atcggcgggc gcggcgtgct gctcggcggc      480

gtgccgggcg tgcaggcggg ccacgtcgtc gtgattggcg gcggcgtcgt cggcacgaac      540

gccgcgaaaa tggccatggg cctcggcgcg aaggtcacgg tgctggacgt gaaccacggg      600

cgcctctcgt acctcgacga cgtgttcttc gggaagctca ccaccatgat gagcaacgag      660

gcgaacatcc gctccatcct gcccgaagcg gacctcgtga tcggcggcgt gctgatcccc      720

ggggcgaagg cgccgcacct tgtcacgcgc gacatgctgg cgaccatgca ggaaggcagc      780

gtcatcgtcg acgtggcggt ggaccagggc ggatgcgtgg agaccattca cgcgacgacg      840

cacgacgatc ccacgtacat cgtggacggc gtgatccact acggcgtggc gaacatgccg      900

ggcgcggtgc cgcgcaccag cacgttcgcg ctcacgaacc agaccattgg gtacgtgctg      960

cagctcgcgg acaagggcgt ggaggcactc agcgccagca agccgctgct gcgtggcctg     1020

aacaccatcg gcgggaagct gacgtacgcg ggcgtcgcgg aagcgttcgg cctgacgtac     1080

accgcgcctg aagtggcgct ggcgtaa                                         1107


<210>  23
<211>  948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 23

<400>  23
atggagccca ctatgagcca attcgaacag ctgtaccgcc aggtggccct cagtgtcgcc       60

ggcaacccgg tcgtggaaaa agtcttgagc aagcagggct gggcgctggc gcagcgtttt      120

gtatcgggcg agacggcgca ggacgccatc aaggccatca agcggctgga agcccagggc      180

atctccggca acctcgacct gctgggcgag ttcgtgaaca ccccggaacc cgccaatgcc      240

aacaccgaga tgattctggc gaccattgac caggtgcacg cggcgggcct cacgccctac      300

aacagcgtga aaatgtcggc gctgggccaa gggcagaccg cgccggacgg ccaggacctc      360

ggctacgtca acacccgccg cgtcgtggag cgggccaagc gctacggcgg cttcgtcaat      420

ctggacatgg aagaccacac ccgcgtggac tcgactctgc agattttccg ccgcctggtc      480

aaggagttcg gccaccagca tgtgggaacg gtgttgcagg cctacctgca ccgctcggaa      540

gacgaccgcc gcagcctgga cgacctgcgc cccaacctcc gcatggtgaa gggcgcctac      600

ctggagcccg cctccgtcgc cctgcagagc aaaaccgaca ttgacgccgc ctaccgccgc      660

ctggtctacg agcacctcaa ggccggcaac tactgcaacg tggccaccca cgaccaccac      720

atcatctacg acgtgatgca ctttgcgctg gcccacggca tccctaagga ccagttcgaa      780

ttccagctgc tgtacggcat ccgcgaggac ctgcagcgcg aattggccga ggccggctac      840

acggtgcgct cgtacattcc tttcggcaag gactggtacg gctactactc gcgccgcatc      900

gccgagcgcc cgcagaacgt gatgttcgtg ctgcgcggcc tgctgtaa                   948


<210>  24
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid sequence encoding enzyme 24

<400>  24
atgaaaaaca ttgtggttat cggcgcgggc aatatcggtt cggcaatcgc ctggatgctg       60

gccgcatcag gcgattatcg catcacggtt gccgatcgtt cagccgatca gctggccaat      120

gtgccggcgc atgaacgggt cgacatcgtc gacattaccg accgtcccgc tctggaagca      180

ctgctaaaag gcaaattcgc cgtgctctcc gccgccccca ccgaattcca cctgacggcg      240

ggtattgccg aagcggccgt tgccgtcggc acgcattatc tcgatctcac cgaagacgtg      300

gaatccaccc gcaaggtcaa ggcgctggcg gaaacggccg aaaccgcgct cattccgcaa      360

tgcggcctcg cccccggctt catctccatc gtcgctgccg atctcgccgt caagttcgac      420

aagctggaca gcgtgcgcat gcgcgtcggc gctctgccgc aatatccgtc caatgcgctc      480

aactacaacc tcacctggag taccgacggg ctgatcaacg aatatatcga gccctgcgaa      540

ggattcgtcg aaggccgcct caccgccgtt ccggcccttg aggagcgcga ggagttctcg      600

ctcgatggca tcacctacga ggcgttcaac acctcgggcg gtctcggtac gctttgcgcg      660

acgctggaag gcaaggtgcg gaccatgaac taccgcacta tccgttatcc cggccatgtg      720

gcgatcatga aggcgctttt gaacgacctc aacctgcgca accgccgcga tgtgctgaag      780

gacctgttcg aaaacgccct gcccggcacc atgcaggatg tggtcatcgt cttcgtcacc      840

gtctgcggca cccgcaacgg ccgcttcctg caggaaacct atgccaacaa ggtctatgcc      900

ggcccggttt ccggccggat gatgagcgcc atccagatca ctaccgccgc cggcatctgc      960

acggttctcg acctgctcgc ggaaggcgcc ctgccgcaga agggcttcgt tcgacaggag     1020

gaagtggcgc tgccgaagtt cctcgaaaac cggtttggcc ggtattatgg ctcgcatgag     1080

ccgctggcgc gggttgggtg a                                               1101


