               SEQUENCE LISTING

<110> Eberhard Karls Universitaet Tuebingen

<120> S,S-EDDS Biosynthesegencluster und Verfahren zur Biosynthese von S,S-EDDS

<130> P 53 563 WO

<160> 64

<170> BiSSAP 1.2

<210> 1
<211> 541
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1639

<400> 1
Met Thr Arg Lys Glu Pro Ala Asp Thr Pro Leu Gly Asp Ala Phe His 
1               5                   10                  15      
Leu Tyr Asp Thr Thr Leu Arg Asp Gly Ala Gln Arg Glu Gly Ile Ser 
            20                  25                  30          
Tyr Ser Val Ala Asp Lys Leu Ala Val Ala Arg Leu Leu Asp Glu Leu 
        35                  40                  45              
Gly Val Gly Phe Ile Glu Gly Gly Trp Pro Gly Ala Leu Pro Lys Asp 
    50                  55                  60                  
Thr Glu Phe Phe Ala Arg Ala Ala Ser Gly Glu Leu Lys Leu Arg His 
65                  70                  75                  80  
Ala Ala Leu Val Ala Phe Gly Ala Thr Arg Lys Ala Gly Thr Lys Ala 
                85                  90                  95      
Glu Gln Asp Gln Gln Val Arg Ala Leu Leu Asp Ser Gln Ala Pro Val 
            100                 105                 110         
Val Thr Leu Val Ala Lys Ser Asp Leu Arg His Ile Glu Arg Ala Leu 
        115                 120                 125             
Arg Val Asp Val Asp Glu Ala Cys Glu Met Val Arg Asp Thr Val Ala 
    130                 135                 140                 
Phe Leu Val Gly Glu Gly Arg Arg Val Phe Leu Asp Ala Glu His Phe 
145                 150                 155                 160 
Phe Asp Gly Tyr Ala Phe Ser Pro Asp Thr Ala Leu Lys Val Leu Asp 
                165                 170                 175     
Ala Gly Val Asn Ala Gly Ala Asp Val Ala Val Leu Cys Asp Thr Asn 
            180                 185                 190         
Gly Gly Gln Leu Pro Leu Gly Leu Ala Glu Thr Val Arg Glu Val Lys 
        195                 200                 205             
Glu Arg Thr Gly Phe Arg Leu Gly Ile His Cys Gln Asp Asp Thr Ser 
    210                 215                 220                 
Cys Ala Val Ala Asn Ser Val Ala Ala Val Gln Ala Gly Val Thr His 
225                 230                 235                 240 
Val Gln Cys Thr Ala Asn Gly Tyr Gly Glu Arg Ala Gly Asn Ala Asp 
                245                 250                 255     
Leu Phe Ala Val Thr Gly Asn Leu Val Thr Lys Leu Gly Met Glu Val 
            260                 265                 270         
Leu Pro Thr Gly Gly Ala Ala Glu Leu Thr Arg Val Ser His Ala Leu 
        275                 280                 285             
Ala Glu Ile Ala Asn Ile Ala Pro Tyr Thr His Gln Ala Tyr Val Gly 
    290                 295                 300                 
Ala Ser Ala Phe Ala His Lys Ala Gly Leu His Ala Ser Ala Ile Lys 
305                 310                 315                 320 
Val Asp Pro Leu Leu Tyr Asn His Ile Asp Pro Ala Ser Val Gly Asn 
                325                 330                 335     
Asp Met Arg Val Leu Val Thr Glu Met Ala Gly Arg Ala Ser Leu Glu 
            340                 345                 350         
Leu Lys Gly Arg Glu Leu Gly Val Asp Leu Ala Gly Gln Pro Glu Ala 
        355                 360                 365             
Leu Thr Ser Ala Val Lys Lys Val Lys Arg Leu Glu Ser Glu Gly Trp 
    370                 375                 380                 
Ser Phe Glu Ala Ala Asp Ala Ser Leu Glu Leu Leu Leu Arg Arg Glu 
385                 390                 395                 400 
Val Asp Gly Pro Gln Ser Asp Val Leu Asp Glu Pro Pro Phe Glu Leu 
                405                 410                 415     
Glu Ser Tyr Arg Val Val Leu Asp His Arg Ser Asp Gly Glu Val Val 
            420                 425                 430         
Ser Glu Ala Thr Val Lys Val His Val Ala Gly Gln Arg Val Ile Ala 
        435                 440                 445             
Thr Ala Glu Gly Asn Gly Pro Val His Ala Leu Asp Ala Ala Leu Arg 
    450                 455                 460                 
Glu Ala Leu Ser Pro His Leu Ser Trp Leu Asp Ser Val Glu Leu Ala 
465                 470                 475                 480 
Asp Tyr Lys Val Arg Ile Leu Pro Gly His Pro Gly Thr Asp Ala Val 
                485                 490                 495     
Thr Arg Val Leu Val Glu Thr Ser Asp Gly Glu Arg Glu Trp Thr Thr 
            500                 505                 510         
Val Gly Val His Gly Asn Ile Val Glu Ala Ser Trp Leu Ala Leu Cys 
        515                 520                 525             
Asp Ala Leu Val His Lys Ser Leu Ser Glu Gly Pro Ala 
    530                 535                 540     

<210> 2
<211> 1626
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1639


<400> 2
gtgacccgca aggagcccgc cgatacaccg ctcggcgacg ccttccacct gtacgacacg      60

acgttgcgcg acggtgcgca gcgtgagggg atctcctact ccgtcgcgga caaactggcg     120

gtggcgaggc tgctcgacga actcggggtc gggttcatcg aaggcggatg gccgggcgcg     180

ctgcccaagg acacggaatt cttcgcccgt gcggcttcgg gcgagctgaa acttcgccat     240

gccgcgctcg tcgcgttcgg cgcgacgcgg aaggcgggca ccaaggccga gcaggatcag     300

caggtgcggg ccctgctcga ctcgcaggca ccggtggtca cgctcgtggc caaatccgat     360

ctgcggcaca tcgaacgcgc gctgcgggtc gacgtcgacg aagcttgcga gatggtgcgc     420

gacaccgtcg cgttcctcgt cggtgaagga cgtcgcgtct tccttgacgc ggaacacttt     480

ttcgacggct acgcgttctc cccggacacc gcgctgaagg tgctcgacgc gggcgtgaac     540

gcgggtgccg acgtcgccgt gctgtgcgac accaacggcg ggcaactgcc gctcggactc     600

gcggaaaccg tccgcgaggt caaggaaagg accggattcc ggctcggaat ccattgtcag     660

gacgacactt cctgcgcggt ggcgaattcc gtcgccgccg tgcaggccgg cgtgacgcac     720

gtccagtgca ccgccaatgg ttacggcgag cgggcgggta acgccgatct tttcgccgtg     780

acagggaatt tggtgaccaa gctcggtatg gaggtgctcc cgaccggagg cgccgccgag     840

ctcacccggg tctcccatgc ccttgccgaa atcgcgaaca tcgcccccta cacccaccag     900

gcttacgtag gggcgtcggc cttcgcccac aaggcgggac tgcacgcgag cgcgatcaag     960

gtggatccgt tgctgtacaa ccacatcgat ccagcttctg tcggcaatga catgcgggta    1020

ctggtcaccg agatggccgg cagggccagc ctggagctca agggacgtga gctcggggtc    1080

gaccttgccg gccagcccga ggcgctgacg agcgccgtga agaaggtgaa acgcctcgaa    1140

tccgaaggct ggtccttcga agccgcggac gcttcactgg aactgctgct gcggcgggag    1200

gtcgacggcc cgcagagcga cgtcctcgac gaaccgccgt tcgaactcga gtcgtaccgg    1260

gtcgtcctcg accaccggtc cgacggcgag gtcgtctccg aggcgacggt gaaggtgcac    1320

gtcgccgggc agcgcgtgat cgcgaccgcc gagggcaacg ggcccgtgca cgcgctcgac    1380

gccgccctgc gcgaggcgct cagcccgcat ctgtcctggt tggacagtgt cgagctggcc    1440

gactacaagg tgcggatcct gcccggccat ccgggcaccg acgccgtcac ccgtgtgctc    1500

gtcgagacca gcgacggcga gcgcgagtgg accaccgtcg gcgtgcacgg caacatcgtc    1560

gaggcgagct ggctggcgct gtgcgacgcg ctcgtgcaca agtccctcag cgagggcccg    1620

gcgtga                                                               1626


<210> 3
<211> 256
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1640

<400> 3
Met Arg Leu Ala Arg Ile Ala His Pro Gly Gly Val Ala Phe Ala Ser 
1               5                   10                  15      
Ile Glu Gly Asp Gly Asp Asp Ala Gln Val Leu Glu Ile Ala Glu His 
            20                  25                  30          
Pro Phe Gly Asn Pro Asn Phe Thr Gly Lys Arg Trp Pro Leu Ala Asp 
        35                  40                  45              
Val Arg Leu Leu Ala Pro Ile Leu Pro Ser Lys Val Ile Ala Val Gly 
    50                  55                  60                  
Arg Asn Tyr Ala Lys His Ala Ala Glu Phe Gly Asn Glu Val Pro Gln 
65                  70                  75                  80  
Asp Pro Met Leu Phe Ile Lys Pro Ser Thr Thr Val Ile Gly Pro Asn 
                85                  90                  95      
Val Pro Ile Arg Arg Pro Arg Gly Val Gly Arg Val Asp Phe Glu Gly 
            100                 105                 110         
Glu Leu Ala Ile Val Ile Gly Gln Pro Val Lys Asn Val Pro Ala Ala 
        115                 120                 125             
Arg Ala Ala Ser Ala Ile Leu Gly Tyr Thr Val Ala Asn Asp Val Ser 
    130                 135                 140                 
Ala Arg Asp Leu Gln Lys Ser Asp Gly Gln Trp Gly Arg Ala Lys Gly 
145                 150                 155                 160 
Phe Asp Thr Phe Cys Pro Leu Gly Pro Trp Ile Glu Thr Ser Leu Asp 
                165                 170                 175     
Ala Ala Asp Leu Ala Leu Lys Ser Glu Val Asp Gly Val Leu Lys Gln 
            180                 185                 190         
Asp Gly Arg Thr Ser Asp Leu Val His Lys Ile Pro Glu Leu Val Glu 
        195                 200                 205             
Phe Val Ser Gly Val Met Thr Leu Leu Pro Gly Asp Val Ile Leu Thr 
    210                 215                 220                 
Gly Thr Pro Glu Gly Val Gly Pro Ile Glu Asp Gly Gln Ser Val Ser 
225                 230                 235                 240 
Ile Thr Ile Glu Gly Ile Gly Thr Leu Thr Asn Pro Val Gln Asp Ile 
                245                 250                 255     



<210> 4
<211> 771
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1640


<400> 4
gtgcgtctag cccgaattgc tcatcccggt ggtgtcgcgt tcgcttcgat cgaaggggac      60

ggcgacgacg cccaggtact ggaaatcgcc gagcacccct tcggcaaccc caacttcacc     120

ggcaaacgct ggccgctcgc cgacgtccgg ctgctcgcgc cgatcctgcc gtcgaaggtg     180

atcgcggtcg gccggaacta cgccaagcac gcggccgagt tcggcaacga ggtcccgcag     240

gacccgatgc tgttcatcaa gccgtcgacc acggtgatcg ggccgaacgt gccgatccgc     300

cgtccgcgcg gtgtcggccg tgtcgacttc gagggcgaac tggcgatcgt catcggccag     360

ccggtcaaga acgtgcccgc cgcccgcgcg gcgagcgcga tcctcggcta caccgtggcg     420

aacgacgtca gcgcgcgtga cctgcagaag tccgacggcc agtggggcag ggcgaagggt     480

ttcgacacct tctgcccgct gggcccgtgg atcgagacct cgctcgacgc ggccgatctc     540

gcgctcaagt ccgaggtgga cggtgtgctc aagcaggacg gccggacgtc ggacctggtg     600

cacaagatcc ccgagctggt cgaattcgtg tccggggtga tgaccctgtt gcccggtgac     660

gtcatcctga ccggcacgcc cgagggcgtc ggcccgatcg aggacggcca gtccgtgtcg     720

atcaccatcg agggcatcgg caccctgacg aacccggttc aagacatcta g              771


<210> 5
<211> 411
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1641

<400> 5
Met Asn Glu Arg Thr Asn Cys Val Val Val Gly Gly Gly Pro Ala Gly 
1               5                   10                  15      
Met Val Ala Gly Leu Leu Leu Ala Arg Ala Gly Val Glu Val Thr Val 
            20                  25                  30          
Leu Glu Lys His Gln Asp Phe Leu Arg Asp Phe Arg Gly Asp Thr Val 
        35                  40                  45              
His Pro Ser Thr Leu Thr Leu Leu Asp Glu Leu Gly Leu Ser Glu Lys 
    50                  55                  60                  
Phe Leu Ser Leu Pro His Ser Glu Ile Ala Tyr Ala Gly Phe Pro Ala 
65                  70                  75                  80  
Glu Asp Gly Thr Met Met Arg Leu Ala Asp Leu Thr Arg Leu Lys Val 
                85                  90                  95      
Ala His Pro Tyr Ile Ala Met Val Pro Gln Trp Asp Phe Leu Asp Leu 
            100                 105                 110         
Leu Ala Asp Ala Gly Ala Lys Glu Pro Thr Phe Thr Leu Arg Gln Ser 
        115                 120                 125             
Thr Glu Met Thr Gly Leu Ile Phe Glu His Gly Arg Val Ser Gly Val 
    130                 135                 140                 
Arg Tyr Arg Asp Ala Asp Gly Lys Ala Gly Glu Leu Arg Ala Asp Leu 
145                 150                 155                 160 
Val Ile Ala Ala Asp Gly Arg Trp Ser Leu Ala Arg Arg Glu Ala Gly 
                165                 170                 175     
Leu Met Thr Lys Asp Tyr Pro Ile Pro Phe Asp Ala Trp Trp Phe Arg 
            180                 185                 190         
Ile Ser Arg Arg Asp Gly Glu Arg Glu Gly Met Leu Thr Pro Lys Met 
        195                 200                 205             
Arg Asp Arg Arg Phe Ala Val Pro Leu Pro Arg Lys Gly Tyr Phe Gln 
    210                 215                 220                 
Ile Ala Tyr Leu Ser Pro Lys Gly Gln Asp Leu Arg Asp Lys Gly Ile 
225                 230                 235                 240 
Glu Ala Phe Arg Glu Asn Val Ala Ala Ile Leu Pro Glu Leu Ala Asp 
                245                 250                 255     
Arg Val Asp Glu Leu Lys Thr Thr Asp Asp Val Lys Phe Leu Asp Val 
            260                 265                 270         
Lys Met Asn Leu Leu Arg Lys Trp His Leu Asp Gly Leu Leu Cys Ile 
        275                 280                 285             
Gly Asp Ala Ala His Ala Met Ser Pro Val Gly Gly Val Gly Ile Asn 
    290                 295                 300                 
Leu Ala Val Gln Asp Ala Val Ala Ala Ala Thr Leu Leu Ala Glu Pro 
305                 310                 315                 320 
Leu Arg Arg Gly Arg Pro Ser Val Ala Asp Leu Ala Lys Val Arg Lys 
                325                 330                 335     
Arg Arg Leu Ala Pro Thr Met Leu Val Gln Gly Leu Gln Arg Ile Leu 
            340                 345                 350         
His Lys Asn Val Met Gly Pro Val Met Ala Gly Lys Arg Asn Gly Pro 
        355                 360                 365             
Pro Ala Pro Met Val Lys Leu Phe Ser Arg Phe Pro Ala Leu Ser Tyr 
    370                 375                 380                 
Ile Pro Ala Arg Leu Leu Gly Leu Gly Leu Arg Pro Glu His Ala Pro 
385                 390                 395                 400 
Ala Phe Ala Arg Arg Ala Met Glu Pro Ala Gly 
                405                 410     

<210> 6
<211> 1236
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1641


<400> 6
atgaacgaac gtacgaactg cgtggtcgtc ggcggtggcc ccgcgggtat ggtcgccgga      60

ttgctgctgg ccagggccgg ggtcgaggtc accgtgctgg agaagcacca ggacttcctg     120

cgggacttcc gcggcgacac cgtgcacccg tcgacgttga cgttgctgga cgagctgggc     180

ctcagcgaga aattcctcag cctgccgcac agcgagatcg cctacgccgg cttccccgcc     240

gaggacggca cgatgatgcg cctcgccgac ctgaccaggc tgaaggtggc gcacccgtac     300

atcgccatgg tcccgcagtg ggacttcctg gacctgctcg ccgacgccgg ggcgaaggaa     360

cccacgttca cgctgcggca gagcaccgag atgaccgggc tgatcttcga acacggccgg     420

gtgagcgggg tccgctaccg cgacgccgac gggaaggccg gcgaactgcg cgccgacctg     480

gtgatcgccg ccgacggacg ctggtcgctg gcccgccgcg aggccgggct catgacgaag     540

gactacccca tcccgttcga cgcgtggtgg ttccggatct cacggcggga cggggaacgc     600

gaaggcatgc tgaccccgaa gatgcgggat cgccgcttcg ccgtgccgct gccccgcaag     660

ggctacttcc agatcgccta cctcagcccc aagggccagg acctgcgcga caagggcatc     720

gaggcgttcc gggagaacgt ggccgcgatc ctgcccgagc tggccgaccg cgtggacgag     780

ctgaagacga cggacgacgt caaattcctc gacgtcaaga tgaacctgct gcggaagtgg     840

catctcgacg ggctgctgtg catcggtgac gcggcgcacg cgatgtcgcc ggtcggcggg     900

gtcggcatca acctcgcggt gcaggacgcg gtcgcggccg ccaccctgct cgccgaaccg     960

ctgcgccgcg gcaggccgtc ggtggcggat ctggcgaagg tccgcaagcg ccgtctcgcg    1020

cccacgatgc tggtgcaggg gctgcagcgg attctgcaca agaacgtgat ggggccggtg    1080

atggcgggca agcgcaacgg cccgcccgcg ccgatggtga agctgttcag ccggttcccc    1140

gcgctgtcct acatccccgc gcggctgctg ggcctggggc tgcggcccga gcacgccccg    1200

gccttcgcgc ggcgggcgat ggaaccggcc ggttag                              1236


<210> 7
<211> 244
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1642

<400> 7
Met Cys Leu Asp Ile Asp Asp Thr Leu Ile Asp Cys Thr Ala Ala Ile 
1               5                   10                  15      
Arg Leu Ser Leu Ser Ala Leu Thr Gly Gln Asn Asp Leu Trp Pro Leu 
            20                  25                  30          
Trp Asp Leu Ile Thr Glu Glu His Val Ala Leu Val Val Ala Gly Glu 
        35                  40                  45              
Ile Asp Tyr Ala Thr Met His Tyr Lys Arg Thr Glu Cys Phe Leu Ala 
    50                  55                  60                  
Glu Ile Gly Ile Leu Ala Asp Glu Gln Gln Val Ser Gly Phe Glu Arg 
65                  70                  75                  80  
Arg Arg Arg Glu Ile Leu Thr Arg Ser Trp Gln Leu Phe Glu Asp Val 
                85                  90                  95      
Leu Pro Cys Leu Glu Trp Leu Arg Ala Ala Gly Val Leu Val Ala Ala 
            100                 105                 110         
Val Thr Asn Ala Ser Gly Ala His Gln Arg Lys Lys Ile Ala Asp Leu 
        115                 120                 125             
Gly Leu Ala Arg Phe Phe Asp His Val Ala Ile Ala Gly Glu Leu Gly 
    130                 135                 140                 
Val Ala Lys Pro Asp Pro Ala Met Phe His Ser Val Cys Leu Gly Leu 
145                 150                 155                 160 
Gly Cys Asp Pro Ala Gln Ala Val His Val Gly Asp Lys Leu Asp Thr 
                165                 170                 175     
Asp Ala Ile Gly Ala Arg Asp Ala Gly Leu Gly Ala Val Trp Leu Asp 
            180                 185                 190         
Arg Asp Gly Ile Ala Glu Arg Ala Pro Ala Gly Val His Thr Ile Ser 
        195                 200                 205             
Gly Leu Asp Glu Leu Pro Glu Leu Leu Val Ser Glu Phe Ala Lys Leu 
    210                 215                 220                 
Gly Val Pro Ala Gln Arg Ala Thr Glu Thr Pro Ala Phe Thr Val Arg 
225                 230                 235                 240 
Asn Ser Val Leu 
                

<210> 8
<211> 735
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1642


<400> 8
gtgtgcctcg acatcgatga cacgttgatc gactgcacgg cggcgatccg cctcagcctg      60

agcgccctca ctggccagaa cgacctttgg ccgctgtggg atctcatcac cgaagagcat     120

gtcgcgctgg tggtcgcggg cgaaatcgat tacgcgacca tgcattacaa gcgtacggaa     180

tgtttcctcg ccgagatcgg cattttggcc gacgaacagc aggtcagcgg cttcgaaaga     240

cgtcgtcgtg aaattctcac ccgttcgtgg caattgttcg aagatgtcct cccatgcctt     300

gaatggctgc gggccgccgg tgttctcgtc gccgcggtca cgaacgcctc gggcgcgcat     360

cagcgcaaga agatcgccga cctcggcctc gcccggttct tcgatcacgt ggccatcgcc     420

ggtgaactcg gagtagccaa acccgacccg gcgatgttcc actcggtctg cctcggcctc     480

ggctgcgacc cggcgcaggc cgtccacgtc ggcgacaaac tcgacaccga cgccatcggc     540

gcgcgcgacg ccggcctggg ggccgtctgg ctcgaccggg acggcatcgc cgagcgcgcc     600

ccggcgggcg tgcacaccat ctcgggcctc gacgagctgc ctgagctgct cgtttccgag     660

ttcgcgaagc tcggcgtgcc cgctcagcgc gctactgaga cccccgcttt cacggtgcgg     720

aacagcgtgc tctag                                                      735


<210> 9
<211> 70
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1643

<400> 9
Met Val Glu Gly Arg Gln Thr Thr Pro Ala Thr Phe Asp His Pro Leu 
1               5                   10                  15      
Val Thr Ser Gly Ser Arg Leu Asn Asp Gly Gly Val Val Val Glu His 
            20                  25                  30          
Gly Phe Ala Gly Ala Gly Ala Gly Leu Thr Leu Ser Val Ala Ala Ile 
        35                  40                  45              
Ala Thr Ile Pro Ala Ala Phe Asp Ala His Val Pro Val Thr Pro Val 
    50                  55                  60                  
Leu Lys Ala Glu Thr Ala 
65                  70  

<210> 10
<211> 213
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1643


<400> 10
gtggttgaag gccgccagac gacaccagcc accttcgacc acccgctggt gacttccgga     60

agccggctga acgacggcgg cgtggtggtc gaacacggtt tcgccggggc cggggccggc    120

ctcacgctct ccgtcgccgc gatcgccacc atccccgccg ccttcgacgc acacgtcccg    180

gtcactccgg tactcaaagc ggagaccgct tag                                 213


<210> 11
<211> 135
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1644

<400> 11
Met Arg Gln Ala Gly Phe Asp Gly Glu Leu Pro Asp Arg Ile Arg Ala 
1               5                   10                  15      
Phe Asp Glu Ile Val Lys Thr His Glu Trp Ser Glu Ser Ala Gly Ser 
            20                  25                  30          
Ile Thr Gln Pro Ile Asp Tyr Tyr Arg Gln Phe Arg Gly Arg Pro Glu 
        35                  40                  45              
Gly Pro Asn Arg Val Tyr Asp Ala Ser Asp Leu Pro Gly Val Gly Tyr 
    50                  55                  60                  
Thr Arg Gln Val Ala Asp Thr Thr Arg Met Gly Leu Gly Glu Ser Trp 
65                  70                  75                  80  
Thr Glu Ala Gly Gln Pro Val Arg Glu His Pro Glu Pro Ser Ser Asp 
                85                  90                  95      
Leu Phe Thr His Thr Ser Gly Pro Asn Gln His Ala Leu Ile Thr Glu 
            100                 105                 110         
Gln Leu Thr Arg His His Tyr Val Met Thr Leu Thr Met Ser Thr Arg 
        115                 120                 125             
Gln Thr Tyr Pro Thr Cys Arg 
    130                 135 

<210> 12
<211> 408
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1644


<400> 12
gtgcggcaag caggcttcga cggcgaactg cctgaccgga tccgagcttt cgacgagatc      60

gtcaagacac acgagtggtc tgaaagtgca ggctcgatca cacaacccat cgactactac     120

cgccagttcc ggggtcgccc ggaaggaccg aaccgggtct acgacgcgag cgacctcccc     180

ggcgtcggct acacccggca ggtggccgac accacccgca tgggactcgg cgagtcctgg     240

accgaagcgg gacagccggt acgggagcac cccgagccgt cgtcagacct tttcacccat     300

accagcggac cgaaccagca tgccttgatc accgagcagc tgacccgaca ccattacgtg     360

atgaccttga ccatgagcac caggcagacc tatccgacgt gtcggtga                  408


<210> 13
<211> 325
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1645

<400> 13
Met Thr Met Arg Ala Ala Tyr Leu Ala Glu Pro Gly Val Val Ala Val 
1               5                   10                  15      
Gly Arg Phe Pro Ile Pro Arg Pro Glu Glu Gly Gln Val Leu Val Glu 
            20                  25                  30          
Met Arg His Ala Ser Ile Cys Gly Ser Asp Val His Ile Val Phe Asp 
        35                  40                  45              
Gly Phe His Asp Gln Glu Arg Leu Gly Ser Pro Gly Tyr Pro Gly His 
    50                  55                  60                  
Glu Gly Ile Gly Val Val Ala Glu Ser Arg Ser Arg Ala Phe Ala Ala 
65                  70                  75                  80  
Gly Asp Pro Val Leu Thr Val Pro Pro Val Glu His Thr Gly Cys Phe 
                85                  90                  95      
Ala Glu Tyr Gln Val Val Asp Glu Gly Ser Leu Val Pro Val Pro Arg 
            100                 105                 110         
Glu Gly Asp Leu Ser Arg Leu Leu Leu Ala Gln Gln Leu Gly Thr Thr 
        115                 120                 125             
Val Phe Gly Met Ala Lys Phe Val Asp Gly Pro Pro Pro Arg Thr Ala 
    130                 135                 140                 
Ala Val Ile Gly Ala Gly Ser Ala Gly Leu Phe Phe Leu Gln Leu Leu 
145                 150                 155                 160 
Arg Arg Met Gly Cys Glu Ser Val Leu Val Ser Asp Leu Asp Pro Gly 
                165                 170                 175     
Arg Leu Val Val Ala Asp Arg Leu Gly Ala Gln Val Val Asp Ala Arg 
            180                 185                 190         
Arg Ala Ala Leu Ala Asp Thr Ala Arg Glu Met Thr Gly Gly Ile Gly 
        195                 200                 205             
Val Asp Leu Val Val Glu Ala Ala Gly Pro Asp Ala Cys Arg Val Glu 
    210                 215                 220                 
Ala Val Glu Ala Val Arg Glu Arg Gly Thr Ile Gly Phe Phe Gly Phe 
225                 230                 235                 240 
Pro Glu Arg Lys Gly Thr Ala Pro Phe Pro Val Glu Arg Ala Phe Arg 
                245                 250                 255     
Lys Ser Val Arg Met Glu Trp Val Asn Gly Thr Gln Lys Glu Pro Gly 
            260                 265                 270         
Leu Val Ser Phe Arg Arg Ala Val Asp Leu Ile Arg Ser Gly Glu Ile 
        275                 280                 285             
Val Val Asp His Cys Leu Glu His Ala Phe Asp Leu Gly Asp Ile Ala 
    290                 295                 300                 
Glu Ala Phe Ala Ser Ala Arg Arg His Gly Asp Gly His Pro Lys Val 
305                 310                 315                 320 
Gly Ile Ile Leu Arg 
                325 

<210> 14
<211> 978
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1645


<400> 14
atgaccatgc gggcggcata tctggcagag cccggagtgg tcgcggtcgg gcggttcccg      60

ataccgcgcc ccgaggaagg gcaagtgctc gtcgaaatgc ggcacgcctc gatctgcggc     120

tcggacgtgc acatcgtgtt cgacggcttc cacgatcaag agcggttggg cagccctggc     180

tatccagggc acgagggcat cggagtggtg gcggaaagcc gcagccgagc cttcgccgcc     240

ggcgatcctg tgctcaccgt gccgcctgtg gaacacaccg gttgcttcgc cgaataccag     300

gtcgtcgacg aggggagcct ggtaccggtt ccgcgcgagg gcgacctgtc ccgcctgctg     360

ctcgcacaac aactcgggac cacggtgttc gggatggcga aattcgtcga cggaccccca     420

ccccggaccg cggccgtgat cggtgcgggc tccgcgggat tgttcttctt gcagttgctg     480

cgccgcatgg gatgtgagtc cgtgctcgtg tcggacctcg atcccggcag gctcgtcgtc     540

gcggaccggc tgggcgcaca agtggtcgac gcacgacgag cggctctcgc ggacacggca     600

cgcgagatga ccggcggtat cggcgtggac ctcgtcgtcg aagccgccgg gcccgacgcc     660

tgcagggtgg aggcggtcga agccgtccgg gagcgcggca cgatcgggtt cttcggcttc     720

cccgaacgca agggcacggc cccgttcccg gtggagcggg cattccgcaa gtcggtacgg     780

atggaatggg tcaacggaac gcagaaggaa ccgggcctgg tgtcgttccg gcgagccgtg     840

gatctgatcc gaagcggcga gatagtggtc gaccattgcc tcgagcacgc cttcgacctc     900

ggagacatcg ccgaggcgtt cgcgtccgcc cgccgccacg gtgatggcca cccgaaggtg     960

ggaatcattc tgcgctga                                                   978


<210> 15
<211> 448
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1646

<400> 15
Met Asn Trp Ser Gln Leu Leu Val Pro Val Thr Ser Gly Val Ser Val 
1               5                   10                  15      
Ala Leu Ile Val Ala Thr Val Arg Phe Leu Trp Arg Arg Thr Arg Leu 
            20                  25                  30          
Pro Thr Gly Leu Ser Gln Arg Met Thr Arg Arg Asn Tyr Leu Ala Glu 
        35                  40                  45              
Met Leu Val Ile Ser Lys Asn Asp Asn Val Asp Arg Leu Asp Ala Leu 
    50                  55                  60                  
Val Pro Asn Leu Leu Pro Ala Gln Gly Ser Pro Val Leu Val Glu Ile 
65                  70                  75                  80  
Gln Glu Ser Trp Thr Gln Ile Asn Gly Arg Arg Gly Val Arg Val Ile 
                85                  90                  95      
Thr Arg Thr Glu Pro Ala Ser Leu Thr Ala Gly Ala Glu Leu Leu Ala 
            100                 105                 110         
Ala Gly Ile Glu Val Arg Val Ser Arg Ala Leu Thr Ala Asp His Leu 
        115                 120                 125             
Ser Tyr His Leu Phe Ser Gly Ser Glu His His Thr Val Leu Asn Arg 
    130                 135                 140                 
Arg Asn Gly Gly Lys Asp Arg Pro Glu Arg Leu Asp Glu Ile Ser Ala 
145                 150                 155                 160 
Ala Lys Val Phe Arg Ser His Phe Asp Glu Thr Trp Ser Glu Ser Glu 
                165                 170                 175     
Pro Ile Glu Ser Phe Leu Ala Gly Gln Leu Leu Ala Gly Pro Asp Ser 
            180                 185                 190         
Gly Leu Ala Asp Arg Ile Arg Glu Gln Arg Ala Ala Tyr Gln Leu Pro 
        195                 200                 205             
Ala Lys Ala Glu Asp Ala Ile Leu Arg His Leu Ala Phe Arg His Arg 
    210                 215                 220                 
Ala Pro Val Val Phe Val Thr Gly Leu Pro Gly Ala Gly Lys Ser Leu 
225                 230                 235                 240 
Val Arg Arg Ala Leu Ala Glu Glu Leu Arg Arg Trp Arg Met Gln Val 
                245                 250                 255     
Asp Glu Leu Asn Asp Tyr Val Tyr Ala Phe Glu Glu Phe Leu His Ala 
            260                 265                 270         
Leu Met Leu Leu Gly Asp Gly Arg Gly Ala Gly Phe Ser Ala Gln Gln 
        275                 280                 285             
Gly Gly Ala Phe Gln Val Glu Arg Glu Asp Asp Leu Arg Pro Ala Leu 
    290                 295                 300                 
His Thr Leu Gly His Arg Val Trp Glu Asn Arg Arg Ser Asn Pro Ile 
305                 310                 315                 320 
Thr Ile Val Glu Phe Ala Arg Ala Asp Thr Ile Gly Ala Leu Gln Val 
                325                 330                 335     
Phe Gly Asp Glu Val Leu Ala Ala Ser Gln Ile Ile His Val Arg Ala 
            340                 345                 350         
Ser Asp Thr Glu Arg Ser Ala Arg Leu Ala Arg Arg Gly Glu Pro Pro 
        355                 360                 365             
Lys Ile Ser Val Ala Gly Gln Ser Ile Ser Leu Glu Val Ser Asp Glu 
    370                 375                 380                 
His Arg Leu Pro Ser Asn Ala Ala Asp Thr Leu Tyr Ser Arg Asp Asp 
385                 390                 395                 400 
Phe Ala Leu Leu Lys Ala Gln Lys Asn Ile Ala Asn Arg Leu Phe Leu 
                405                 410                 415     
Val Glu Asn Asp Ala Glu Glu Lys Ala His Val Asp Glu Gln Val Thr 
            420                 425                 430         
Ala Phe Val Glu Ala Val Val Arg Pro Tyr Arg Val Leu Ala Arg Thr 
        435                 440                 445             



<210> 16
<211> 1347
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1646


<400> 16
atgaactgga gtcagctcct cgttcccgtg accagcggtg tgtccgtcgc cctcatcgtg      60

gcgaccgtca ggttcctgtg gcggcgcacc cgtctgccga ccggcctctc ccagcggatg     120

acccggcgga actacctggc ggagatgctc gtcatctcca agaacgacaa cgtcgaccgg     180

ctcgacgcac tggtcccgaa tctgctgccg gcacaaggct cccccgtgct cgtcgagatc     240

caggagtcgt ggacgcagat caacggccgg cgcggcgtcc gggtgatcac ccggaccgag     300

cccgcgtccc tgaccgccgg agccgagttg ctcgcagcgg ggatcgaggt tcgcgtgtcc     360

cgcgcactga ccgcggatca cctgtcgtac cacctgttct ccggttcgga acaccacacg     420

gtgctcaacc gccgcaacgg cgggaaggac cggcccgaac gactggacga gatctccgca     480

gccaaggtgt tccgcagcca cttcgacgag acgtggagcg agtccgaacc catcgaatcg     540

ttcctggccg ggcaactcct ggccgggccc gactccggcc tcgcggaccg gatccgggag     600

cagcgcgcgg cgtaccagct gcccgccaag gcggaggacg cgatcctgcg gcatctggcg     660

ttccgccacc gggcgccggt cgtcttcgtc accggcctgc cgggtgccgg caagtcactg     720

gttcgacgag ctctcgccga agagcttcgg cggtggcgga tgcaggtcga cgagctgaac     780

gactacgtct acgcgttcga ggaattcctc cacgccttga tgctcctcgg cgacggtcgc     840

ggtgccggct tcagcgccca gcagggcggc gcgttccagg tggagcgcga ggacgatctc     900

cggcccgccc tgcacacgct cggccaccgc gtctgggaaa accgccggag caacccgatc     960

acgatcgtcg agttcgccag ggccgacacg atcggagcgc tccaggtgtt cggcgacgag    1020

gtactggcgg cgtcgcagat catccacgtc cgcgcctccg acaccgagcg ctccgcccgg    1080

ctggccagac ggggcgaacc accgaagatc tcggtggcgg gtcagtcgat cagtctcgaa    1140

gtgtccgacg agcatcggct gcccagcaac gccgcggaca ccctgtacag cagggatgac    1200

ttcgcactcc tgaaggcaca gaagaacatc gccaaccgcc ttttcctcgt cgagaacgac    1260

gccgaggaaa aggcgcacgt cgacgaacag gtcacggcgt tcgtcgaggc ggtcgtgcgc    1320

ccctaccgag tactcgcgcg tacctag                                        1347


<210> 17
<211> 110
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1647

<400> 17
Met Thr Glu Gln Ala Phe Phe Val Leu Thr Ala Leu Val Asp Thr Pro 
1               5                   10                  15      
Arg His Gly Tyr Gly Ile Val Gly Glu Val Ser Gly Leu Ser Asp Gly 
            20                  25                  30          
Arg Val Lys Leu Lys Val Gly Thr Leu Tyr Gly Val Leu Asp Arg Leu 
        35                  40                  45              
Val Ala Asp Gly Leu Val Glu Pro Asp Arg Glu Glu Val Ala Asn Gly 
    50                  55                  60                  
Arg Leu Arg Arg Tyr Tyr Arg Leu Thr Glu Asp Gly Arg Thr Ala Leu 
65                  70                  75                  80  
Ala Ala Glu Val Gln Arg Gln Ala Ser Asn Ala Arg Ala Ala Ser Glu 
                85                  90                  95      
Arg Leu Arg Ala Trp Arg Pro Ala Asp Thr Gly Gly Leu Ala 
            100                 105                 110 

<210> 18
<211> 333
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1647


<400> 18
atgacggagc aggcgttctt cgtgctcacc gcgctggtgg acacgccgcg gcatgggtac      60

gggatcgtcg gcgaggtgag cggtctctcg gacggccggg tgaagctgaa ggtcggcacg     120

ctgtacggcg tgctggatcg gctggtcgcg gacggtttgg tcgagccgga tcgggaggag     180

gtcgccaacg ggcggctccg ccggtactac cggctgaccg aggacggccg cacggcgctc     240

gcggccgagg tccaacggca ggcctcgaac gcccgcgccg cctcggaacg gctgcgcgcg     300

tggcggccgg cggacaccgg gggcctggcg tga                                  333


<210> 19
<211> 331
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1648

<400> 19
Met Asn Arg Leu Glu Glu Arg Tyr Arg Arg Val Leu Arg Leu Leu Pro 
1               5                   10                  15      
Ala Ser Tyr Arg Gln Ala Trp Glu Glu Asp Met Val Ala Thr Phe Leu 
            20                  25                  30          
His Ser Glu Met Pro Glu Asp Ala Glu Asp Ala Glu Phe Ala Val Asp 
        35                  40                  45              
His Gly Arg Pro Ser Trp Pro Glu Val Ala Ser Val Val Ala Leu Ala 
    50                  55                  60                  
Val Arg Leu Arg Leu Gly Gly Asp Gly Ala Pro Leu Arg Tyr Leu Val 
65                  70                  75                  80  
Trp Gly Glu Thr Val Arg Arg Leu Ala Leu Val Gly Leu Leu Val Gln 
                85                  90                  95      
Ala Val Ala Ala Leu Val Gly Ile Gly Ala Trp Leu Trp Ser Pro Ser 
            100                 105                 110         
Val Thr Asn Pro Ile Pro Ala Asp Val Gln Thr Leu Leu Gly Leu Val 
        115                 120                 125             
Trp Val Ala Ala Tyr Leu Cys Leu Val Thr Gly Arg Arg Arg Ala Ala 
    130                 135                 140                 
Arg Trp Leu Ala Val Thr Ala Leu Ala Gln Ala Ser Val Phe Phe Gly 
145                 150                 155                 160 
Val Asp Leu Val Ala Val Glu Gly Ala Tyr Gly Leu Ser Gly Thr Val 
                165                 170                 175     
Gly Leu Leu Leu Glu Ala Leu Pro Val Val Ala Leu Val Ala Phe His 
            180                 185                 190         
Arg Gln Ala Pro Pro Val Lys Ala Arg Pro Trp Leu Val Ala Leu Leu 
        195                 200                 205             
Ala Gly Val Gly Leu Leu Thr Val Ala Met Ser Val Thr Tyr Val Ser 
    210                 215                 220                 
Val Pro Ala Leu Val Asp Trp Pro Gly Val Asp Cys Ala Ala Val Phe 
225                 230                 235                 240 
Val Ala Ala Val Val Tyr Leu Ser Val Pro Arg Leu Gly Trp Arg Ser 
                245                 250                 255     
Ala Ala Val Ser Trp Ser Thr Thr Leu Ala Ser Leu Ala Leu Val Ala 
            260                 265                 270         
Leu Val Gln Arg Val Val Thr Leu Leu Asp Tyr Leu Arg Leu Ala Ala 
        275                 280                 285             
Arg Thr Ala Glu Leu Asp Ile Met Ile Ala Ile Ala Ala Gly Gln Thr 
    290                 295                 300                 
Val Ala Val Leu Ala Ile Ser Val Pro Leu Ala Met Leu Ala Val Lys 
305                 310                 315                 320 
Ala Val Arg Ala Leu Pro Pro Val Ala Ala Arg 
                325                 330     

<210> 20
<211> 996
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1648


<400> 20
gtgaaccgcc tggaggagcg gtaccggcgg gtgctgcggc tgctccccgc ctcctatcgt      60

caggcgtggg aggaggacat ggtcgccacc ttcctgcaca gcgagatgcc ggaggacgcc     120

gaggacgcgg agttcgccgt cgaccacggc aggccgagct ggccggaggt ggcgagcgtc     180

gtggcgctgg cggtgcggct gcggctggga ggcgacggcg cgcccctccg ctacctcgtg     240

tggggtgaga cggtccggcg gctggcgctg gtggggttgc tcgtgcaggc ggtggccgcg     300

ctggtcggta tcggggcgtg gctgtggtct ccctcggtga cgaatccgat cccggccgac     360

gtgcagaccc tgctcggctt ggtctgggtg gcggcttatc tgtgcctggt gaccggcagg     420

cggcgcgcgg cgcggtggct cgcggtgacg gcgctggctc aagcctcggt cttcttcggc     480

gtggatctcg tggccgtcga gggcgcgtac gggctgtccg ggaccgtcgg actcctgctg     540

gaggcgctgc cggtggtggc actggtcgcg ttccatcggc aggccccacc ggtgaaagcg     600

cggccgtggc tcgtcgcgct gcttgccggt gtcggcctcc tgacggtcgc gatgtcggtc     660

acctatgtca gcgttccggc gctcgtggac tggccgggcg tggactgtgc ggcggttttc     720

gtcgccgcgg tcgtctactt gagcgtgcct cgcctgggct ggcggagtgc cgcggtgtcg     780

tggtcgacga cgctcgcttc gctcgcgctg gtcgccctcg tgcagcgggt cgtgacgctg     840

ctggactacc tccggctcgc ggcccgcacc gcggaactgg acatcatgat cgcgatcgcc     900

gccgggcaga ccgtggcggt tctggcgata tcggtgccgc tcgcgatgct cgccgtcaag     960

gccgtgcgcg cgctgccgcc ggtggctgcc cggtga                               996


<210> 21
<211> 339
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1649

<400> 21
Met Val Leu Ala Leu Pro Phe Val Asp Gln Val Trp Gln Ile Tyr Val 
1               5                   10                  15      
Leu Ile Val Ile Leu Gln Ser Ala Ser Ala Ser Phe Thr Pro Ala Phe 
            20                  25                  30          
Gln Ala Val Leu Pro Asp Leu Leu Pro Asp Glu Arg Asp Tyr Thr Lys 
        35                  40                  45              
Ala Leu Ser Leu Ser Gln Leu Ala Ser Thr Met Glu Ser Leu Leu Ser 
    50                  55                  60                  
Pro Leu Leu Ala Ala Ala Val Leu Ser Leu Val Ser Phe His Trp Leu 
65                  70                  75                  80  
Phe Thr Gly Thr Ser Leu Gly Phe Ala Ala Ser Ala Ala Leu Val Leu 
                85                  90                  95      
Ser Thr Arg Ile Pro Asp Ala Ala Arg Gly Asp Arg Gly Gly Ala Trp 
            100                 105                 110         
Asp Arg Thr Met Ala Gly Ile Lys Met Tyr Leu Ala Thr Pro Arg Leu 
        115                 120                 125             
Arg Gly Thr Leu Gly Leu Asp Leu Val Val Ala Ala Ala Gly Ser Val 
    130                 135                 140                 
Val Met Val Asn Thr Val Asn Tyr Val Arg Asp Thr Leu Gly Gly Thr 
145                 150                 155                 160 
Gln Ser Asp Val Ala Leu Leu Leu Ala Ala Asn Gly Ala Gly Thr Ile 
                165                 170                 175     
Leu Ala Ala Leu Leu Leu Pro Arg Val Leu Asp Gly Ile Pro Asp Arg 
            180                 185                 190         
Thr Val Met Leu Thr Gly Gly Gly Thr Leu Leu Ala Gly Leu Thr Gly 
        195                 200                 205             
Ala Ile Ala Leu Ser Thr Val Glu His Gly Ala Ala Ala Pro Val Val 
    210                 215                 220                 
Trp Ala Val Ile Gly Leu Gly Thr Gly Leu Val Leu Thr Pro Val Gly 
225                 230                 235                 240 
Arg Val Leu Arg Arg Ser Ser Arg Pro Ala Asp Arg Pro Ala Ile Phe 
                245                 250                 255     
Ala Ala Arg Phe Ser Leu Ser His Ala Cys Trp Leu Leu Ala Tyr Pro 
            260                 265                 270         
Ile Ala Gly Arg Leu Ala Thr Asp Ala Gly Phe Thr Val Thr Trp Leu 
        275                 280                 285             
Val Leu Gly Ala Leu Gly Val Ile Gly Leu Val Thr Ala Val Arg Ala 
    290                 295                 300                 
Trp Pro Arg Asn Asp Asp Glu Asp Arg Pro Arg Pro Lys Ser Arg Pro 
305                 310                 315                 320 
Gly Gln Pro Phe Glu Asp Ile Thr Gly Gln Pro Pro Ala Ala Ala Arg 
                325                 330                 335     
Ala Arg Pro 
            

<210> 22
<211> 1020
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1649


<400> 22
gtggtgctcg ccctgccctt cgtcgaccag gtctggcaga tctacgtcct gatcgtgatc      60

ctccagtccg cgtcggcctc gttcaccccg gcgttccagg ccgtgctccc cgatctcctt     120

cccgacgaac gcgactacac gaaggcactg tcgctgtccc agctggcttc gacgatggag     180

agcctcctca gtccgctcct ggccgccgcc gtgctcagtc tcgtgtcctt ccactggctg     240

ttcaccggca cttcgctcgg tttcgcggcc tccgccgcac tggtgctgag cacccggatc     300

ccggacgcgg cgcgcggcga ccgcggcggg gcctgggatc gcaccatggc cgggatcaag     360

atgtacctcg cgaccccgcg cctgcggggc accctcggcc tcgacctggt ggtcgcggcg     420

gccggctccg tggtcatggt caataccgtg aactacgtcc gagacaccct cggcggaaca     480

cagtccgacg tcgccctgct cctggcggcc aacggcgccg gcaccatcct ggccgcgctc     540

ctgctccccc gtgtactcga cgggatcccc gaccgcaccg tcatgctcac cggcggcgga     600

accctgctcg ccggactgac cggcgccatc gcactgtcca cagtggagca cggggccgcg     660

gcgccggtcg tatgggccgt catcgggctc ggcaccgggc tcgtcctcac tcccgtcggc     720

cgggtactgc gcagatccag ccgtcccgcc gaccggcccg cgatcttcgc cgcccggttc     780

tccctttccc acgcctgctg gctactcgcc tacccgatcg ccggacggct cgccaccgac     840

gccgggttca ccgtcacctg gctcgtcctc ggcgcactcg gcgtcatcgg cctcgtcacg     900

gccgtccgcg cgtggccacg aaacgacgac gaggaccgac cgcggccgaa atcccggcca     960

ggtcaaccct tcgaggacat caccgggcag ccaccggcgg cagcgcgcgc acggccttga    1020


<210> 23
<211> 103
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1650

<400> 23
Met Ser Leu Phe Gly His Arg Asp Tyr Arg His Leu Phe Gly Ala Gln 
1               5                   10                  15      
Leu Val Ala Leu Phe Gly Thr Gly Leu Thr Thr Val Ala Leu Gly Leu 
            20                  25                  30          
Leu Ala Tyr Asp Leu Ala Gly Ser Asp Ala Gly Ala Val Leu Gly Thr 
        35                  40                  45              
Ala Leu Ala Ile Lys Met Ile Thr Tyr Val Thr Val Ala Pro Leu Ala 
    50                  55                  60                  
Val Ala Tyr Ala Ala Thr Gly Cys Arg Ala Val Ser Ser Ser Ser Arg 
65                  70                  75                  80  
Trp Thr Arg Ser Ala Arg Trp Trp Cys Ser Pro Cys Pro Ser Ser Thr 
                85                  90                  95      
Arg Ser Gly Arg Ser Thr Ser 
            100             

<210> 24
<211> 312
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1650


<400> 24
atgtcgctgt tcggtcatcg tgactatcgg catctgttcg gggcgcagct ggtcgcgctg     60

ttcggcactg gattgacgac cgtagcgctc gggctgctgg cctacgactt ggcggggtcc    120

gacgcgggcg ccgtcctggg caccgcgctg gccatcaaga tgatcaccta cgtcacggtg    180

gcgccgctcg ccgtcgcgta cgccgcgacc gggtgccgcg ccgtttcttc ctcgtcacgc    240

tggacgcgat ccgcgcgctg gtggtgctcg ccctgccctt cgtcgaccag gtctggcaga    300

tctacgtcct ga                                                        312


<210> 25
<211> 116
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1651

<400> 25
Met Tyr Ala His Asp Glu Ser Gly Gly Gln Trp Ser Arg Leu Pro Pro 
1               5                   10                  15      
Asp Asp Gln Ile Glu Ala Ala Ser Thr Ala Leu Arg Met Leu Ala Asp 
            20                  25                  30          
Pro Thr Arg Met Arg Met Leu Trp Leu Ile Ser Gly Glu Glu Tyr Asp 
        35                  40                  45              
Val Ala Ser Leu Ala Ala Ala Val Gly Ile Ala Arg Pro Ala Val Ser 
    50                  55                  60                  
Gln His Leu Ala Lys Leu Lys Leu Ala Gly Leu Val Thr Gln Arg Arg 
65                  70                  75                  80  
Asp Gly Arg Arg Ile Leu Tyr Arg Ala Arg Gly Gly His Val Arg Arg 
                85                  90                  95      
Leu Leu Ala Glu Val Met Asn Ala Ala Asp His His Leu His Gly Ile 
            100                 105                 110         
Pro Asp His Asp 
        115     

<210> 26
<211> 351
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1651


<400> 26
atgtacgcac atgacgaatc aggcggccaa tggtcccggc tgccgccgga cgaccagatc      60

gaagccgcgt ccacggcgtt gcggatgctc gcggatccca cccggatgcg gatgctgtgg     120

ctgatcagcg gcgaggagta cgacgtcgcg tcactggcgg ccgcggtggg catcgcgcgt     180

ccggcggtgt cccagcatct ggccaagctc aagctggccg gattggtcac ccagcgcagg     240

gacggccgcc ggatccttta ccgggcccgc ggcgggcacg tccggaggct gctggcggag     300

gtcatgaacg cggccgatca ccaccttcac gggatccccg accacgactg a              351


<210> 27
<211> 375
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1652

<400> 27
Met Asp Gly Pro Asp Ala Thr Arg Ser Leu Leu Pro Ala Gly Phe Gln 
1               5                   10                  15      
Arg Tyr Gly Arg Thr Lys Ala Thr Ala Ala Ala Ala Gly Asp Asp Leu 
            20                  25                  30          
Leu Asp Ile Ile Gly Leu Ser Glu Thr Asp Val Glu Val Tyr Asp Ala 
        35                  40                  45              
Phe Ala Gly Thr Gly Ser Leu Thr Val Ala Glu Ile Arg Arg Arg Thr 
    50                  55                  60                  
Gly Ile Pro Gln Gln Arg Leu Leu Arg Val Leu Gly Ala Leu Thr Glu 
65                  70                  75                  80  
Lys Gly Leu Leu Val Arg Leu Pro Gly Arg Ala Glu Val Tyr Ser Ala 
                85                  90                  95      
Val Arg Pro Glu Ile Ala Leu Glu Ala Met Leu Arg Leu Lys Glu Gln 
            100                 105                 110         
Glu Leu Ala Ser Ala Arg Leu Val Ala Asp Arg Leu Arg Glu Arg Tyr 
        115                 120                 125             
Arg Ala Thr Ser Gly Glu Arg Ala Val Asp Leu Ile Glu Val Ile His 
    130                 135                 140                 
Gly Asp Ala Leu Ile Ala Glu Arg Ala Asp Gln Leu Leu Arg Ser Ala 
145                 150                 155                 160 
Glu Arg Glu Val Ala Phe Val Asp Lys Pro Pro Tyr Ala Arg Thr Pro 
                165                 170                 175     
Ser Val Leu His Pro Ala Glu Arg Asp Leu Leu Gly Arg Gly Val Arg 
            180                 185                 190         
Phe Arg Gly Val Tyr Glu Arg Ser Ala Leu Glu Met His Asp Leu Ser 
        195                 200                 205             
Ser Asp Leu Glu Ala Gly Leu Ala Leu Gly Glu Glu Ala Arg Val Val 
    210                 215                 220                 
Thr Ser Ala Pro Leu Lys Met Ile Val Val Asp Gln Arg Val Gly Leu 
225                 230                 235                 240 
Val Pro Leu Arg Ser Asp Arg Pro Glu Val Gly Ala Ala Leu Val Ile 
                245                 250                 255     
His Pro Cys Ala Leu Leu Asp Ala Leu Gly Ala Val Phe Ala Phe Leu 
            260                 265                 270         
Trp Gln Ser Gly Leu Pro Leu Arg Leu Pro Gly Ser Ala Glu Leu Ala 
        275                 280                 285             
Asp Val Ala Pro Ser Asp Asp Ala Arg Leu Leu Ala Leu Leu Thr Thr 
    290                 295                 300                 
Gly Leu Pro Asp Arg Ser Ile Ala Lys Gln Leu Gly Met Ser Tyr Arg 
305                 310                 315                 320 
Thr Phe Gln Arg Arg Leu Arg Asp Leu Met Thr Ala Leu Gly Ala Thr 
                325                 330                 335     
Thr Arg Phe Gln Ala Gly Leu Gln Val Ala Thr Arg Gly Trp Val Thr 
            340                 345                 350         
Leu Pro Ser Thr Gln Pro Pro Ile Glu Asp Asp Val Ser Glu Arg Ala 
        355                 360                 365             
Gly Ser Pro Ser Pro Arg Pro 
    370                 375 

<210> 28
<211> 1128
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1652


<400> 28
gtggacggtc cggacgcgac gcggtccctt ttgcccgccg gattccagcg gtatggtcgg      60

acgaaggcga ccgcggctgc ggcgggagac gatttgctgg acatcatcgg tctgagtgaa     120

accgacgtcg aggtctacga tgccttcgcc ggcaccggtt cgctgaccgt cgccgaaatc     180

cggcggcgaa ccgggattcc gcaacaacgg ctgctgcgcg tactgggcgc gctgacggaa     240

aaaggtttgc tcgtcaggct tcccggccgg gcggaggtgt attcggcggt gcggccggag     300

atcgcgctgg aggcgatgct ccggctgaag gaacaggaac tcgcgagcgc gcggctggtc     360

gccgaccggt tgcgcgagcg gtaccgggcg acgtccggcg aacgcgcggt cgatctcatc     420

gaagtgatcc acggcgacgc gctgatcgcc gagcgggcgg atcagctgct gcgctcggcc     480

gagcgggagg tcgccttcgt cgacaaaccg ccttacgcgc gaacgccgag tgtgctgcat     540

cccgccgaac gtgatctcct cggccggggg gtgcgctttc gcggggttta cgagcgcagt     600

gcgctggaaa tgcacgacct gtcatccgac ctggaggcag gcctcgcgct cggcgaggag     660

gcccgcgtgg tcaccagcgc cccgctcaag atgatcgtgg tcgaccagcg cgtcggactg     720

gtaccactgc ggtccgatcg ccccgaggtc ggcgcggcct tggtgatcca cccgtgcgca     780

ctgctcgacg cgctcggcgc ggtcttcgct ttcctttggc agagcgggct tccgctgcgc     840

ctgcccggtt cggccgaact ggcggacgtc gccccttccg acgacgcccg cctgctcgcc     900

ttgctgacca cgggcctgcc ggaccggagc atcgccaaac aactcggcat gagctaccgg     960

accttccagc gacggctccg cgacctcatg accgcgctcg gcgcgaccac ccggttccag    1020

gccgggcttc aggtcgccac gcggggttgg gtcaccttgc cgtcgaccca acccccgatc    1080

gaggacgacg tcagcgagcg cgcgggttcg ccttcgccac gtccgtga                 1128


<210> 29
<211> 1347
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1653

<400> 29
Met Phe Pro Arg Ser Pro His Leu Thr Arg His Pro Trp His Pro Val 
1               5                   10                  15      
Ala Ile Leu Ala Ala Ser Ala Leu Val Ala Leu Thr Pro Leu Pro Val 
            20                  25                  30          
Ile Ala Thr Ala Ala Thr Ala Ala Val Ser Gly Pro Ala Pro Val Thr 
        35                  40                  45              
Gly Arg Pro Asp Val His Arg Val Thr Leu Leu Thr Gly Asp Val Val 
    50                  55                  60                  
Thr Tyr Glu Arg Asp Gly Ala Gly His Gly Thr Ala Gln Val Glu Pro 
65                  70                  75                  80  
Ala Val Arg Pro Asp Arg Pro Ser Pro Ala Phe Gln Ile Thr Thr Thr 
                85                  90                  95      
Ala Glu Gly Leu Met Val Tyr Pro Ser Asp Ala Leu Pro Phe Val Gly 
            100                 105                 110         
Lys Gly Leu Leu Ser Pro Asp Leu Phe Asn Val Thr Thr Leu Val Gly 
        115                 120                 125             
Asp Arg Arg Asp Asp Ala Ala Ser Thr Thr Ile Pro Val Ile Val Arg 
    130                 135                 140                 
Tyr Gly Asp Arg Ser Gly Leu Ser Ala Arg Thr Leu Asp Ala Lys Ala 
145                 150                 155                 160 
Lys Ala Leu Pro Gln Thr Gln Arg Leu Thr Pro Leu Val Thr Ala Asn 
                165                 170                 175     
Gly Val Gly Val Gln Val Lys Lys Ala Gly Thr Gly Glu Phe Trp Arg 
            180                 185                 190         
Ser Leu Val Ala Phe Asp Ala Ser Gly Lys Pro Val Leu Asn Gln Gly 
        195                 200                 205             
Ile Ser Gln Val Arg Leu Asp Arg Lys Val Arg Val Thr Leu Asp Lys 
    210                 215                 220                 
Ser Thr Ala Arg Val Gly Ala Pro Ser Ala Trp Ser Gly Gly Trp Thr 
225                 230                 235                 240 
Gly Lys Gly Thr Thr Val Ala Val Val Asp Thr Gly Ile Asp Glu Asn 
                245                 250                 255     
His Pro Asp Leu Ala Gly Lys Thr Val Ala Ser Ala Asp Phe Ser Gly 
            260                 265                 270         
Glu Gly Asp Val Val Asp Arg His Gly His Gly Thr His Val Ala Ser 
        275                 280                 285             
Ile Val Ala Gly Thr Gly Ala Ala Ser Gly Gly Arg Tyr Lys Gly Val 
    290                 295                 300                 
Ala Pro Asp Ala Asn Leu Val Val Ala Lys Val Phe Asp Ala Ser Gly 
305                 310                 315                 320 
Glu Gly Asp Thr Ala Gln Val Met Ala Gly Ile Asp Trp Ala Val Ala 
                325                 330                 335     
Gln Gly Ala Lys Ile Val Asn Leu Ser Leu Gly Ala Gly Val Ser Asp 
            340                 345                 350         
Gly Ala Asp Pro Met Ser Glu Gln Ile Asp Ser Leu Ser Ala Lys Ser 
        355                 360                 365             
Gly Thr Leu Phe Val Val Ala Ala Gly Asn Ser Gly Pro Gly Asp Arg 
    370                 375                 380                 
Thr Val Thr Thr Pro Gly Ala Ala Thr Ser Ala Leu Thr Val Gly Ala 
385                 390                 395                 400 
Leu Asp Arg Glu Asp Lys Ile Ala Trp Phe Ser Ser Arg Gly Pro Arg 
                405                 410                 415     
Leu Arg Asp Ala Ser Val Lys Pro Glu Ile Thr Ala Pro Gly Val Gly 
            420                 425                 430         
Ile Val Ala Ala Arg Ala Ala Asp Thr Ala Leu Gly Glu Pro Val Asp 
        435                 440                 445             
Asp Ser Tyr Thr Ala Ala Ser Gly Thr Ser Met Ala Thr Pro His Val 
    450                 455                 460                 
Ala Gly Ala Ala Ala Ile Leu Leu Gln Gln Arg Pro Gly Leu Thr Gly 
465                 470                 475                 480 
Gln Ala Leu Lys Asn Thr Leu Val Thr Thr Ala Lys Asp Val Gly Leu 
                485                 490                 495     
His Trp Phe Glu Gln Gly Ala Gly Ile Leu Asp Val Ala Arg Ala Val 
            500                 505                 510         
Ser Gln Lys Ala Thr Gly Thr Ala Val Ala Ser Phe Gly Arg Asn Glu 
        515                 520                 525             
Arg Thr Thr Asn Ala Ser Ala Gln Val Val Arg Gln Leu Ser Tyr Thr 
    530                 535                 540                 
Asn Thr Gly Asp Gln Pro Leu Asn Leu Asn Leu Lys Leu Thr Val Arg 
545                 550                 555                 560 
Pro Trp Asp Gly Gly Ala Ala Pro Gly Thr Gly Met Arg Leu Ala Lys 
                565                 570                 575     
Thr Asp Leu Ser Ile Pro Pro Lys Ser Ser Thr Thr Val Asp Leu Ala 
            580                 585                 590         
Val Asn Pro Asn Glu Gly Thr Ala Gly Val Tyr Gly Gly Ala Val Val 
        595                 600                 605             
Ala Thr Thr Ala Asp Gly Thr Asn Ala Val Arg Thr Pro Val Ser Thr 
    610                 615                 620                 
Tyr Asn Ala Ala Glu Leu Phe Pro Val Thr Ile Arg Val Arg Asp Ser 
625                 630                 635                 640 
Ala Gly Gly Pro Ala Gln Ser Ala Ser Ala Gln Leu Ile Asp Asp Ala 
                645                 650                 655     
Ala Gly Ala Gly Asn Arg Asn Asp Pro Phe Leu Asp Gln Val Ser Gln 
            660                 665                 670         
Gln Val Gly Leu Val Asp Gly Val Gly Arg Val Leu Val Pro Ala Gly 
        675                 680                 685             
Arg Tyr Ser Ala Leu Gly Trp Val Met Glu Arg Gly Leu Thr Val Arg 
    690                 695                 700                 
Arg Trp Ser Ala Met Ser Ala Thr Gln Val Ala Val Ser Gly Pro Ala 
705                 710                 715                 720 
Glu Ile Ala Leu Asn Ala Ala Asn Ala Val Pro Ala Gly Leu Ile Thr 
                725                 730                 735     
Pro Thr Pro Thr Asp Leu Arg Asp Arg Thr Val Met Leu Arg Arg Val 
            740                 745                 750         
Ile Pro Gly Gly Ala Gly Val Asn Gly Tyr Val Gly Glu Ala Gly Leu 
        755                 760                 765             
Ala Ser Gly Ala Gly Trp Glu Val Arg Val Thr Pro Ala Ala Ala Thr 
    770                 775                 780                 
Ser Ala Gly Ala Ile Ser Leu Gln Asp Ser Ala Thr Leu Ser Gln Thr 
785                 790                 795                 800 
Ala Val Glu Met Arg Ile Val Gly Gly Gly Pro Ala Val Leu Asn Pro 
                805                 810                 815     
Ala Tyr Asp Val Pro Thr Leu Thr Ala Lys Ser Pro Gly Glu Arg Thr 
            820                 825                 830         
Leu Pro Val Val Phe Gly Gly Ala Gly Asp Leu Thr Gly Leu Asp Val 
        835                 840                 845             
Arg Gly Lys Ala Val Leu Val Arg Ile Pro Val Pro Ala Gly Ala Pro 
    850                 855                 860                 
Asp Pro Val Ser Ala Val Ser Ala Gly Ile Ala Asn Ala Ser Arg Ala 
865                 870                 875                 880 
Val Ser Ala Ala Gly Gly Ala Ala Leu Ile Pro Tyr Ala Gly Ser Pro 
                885                 890                 895     
Gly Ser Leu Ser Val Pro Gly Leu Ser Ser Ala Val Val Pro Thr Leu 
            900                 905                 910         
Ser Leu Gly Trp Asp Glu Gly Glu Lys Leu Arg Thr Ala Gly Ala Val 
        915                 920                 925             
Ser Val Arg Leu Leu Val Arg Ser Ala Pro Asp Ala Met Tyr Asn Leu 
    930                 935                 940                 
Ser Tyr Leu Asp Ala Asn Gly Val Pro Lys Glu Leu Val Arg Arg Val 
945                 950                 955                 960 
Asp Gln Lys Thr Leu Val Ala Thr Lys Thr Gly Tyr Gln Ala Glu Lys 
                965                 970                 975     
Pro Gly Leu Thr Gly Gln Lys Asn Trp Tyr Ala Phe Pro Thr Gly Leu 
            980                 985                 990         
Trp Lys Thr Gln Ala Val Gln Gly Thr Lys Ile Pro Val Pro Gly Ser 
        995                 1000                1005            
Trp Thr Glu Tyr Thr Gly Pro Ala Asn Asp Arg Leu Val Trp Lys Arg 
    1010                1015                1020                
Val Val Thr Leu Ser Gly Asn Asp Thr Ala Gly Arg Arg Ala Ala Leu 
1025                1030                1035                1040
Ser Met Asn Ala Gln Asn Val Tyr Arg Ala Gly Glu Arg Ser Arg Pro 
                1045                1050                1055    
Asp Glu Phe Trp Phe Arg Ala Pro Leu His Ser Gly Thr Val Glu Leu 
            1060                1065                1070        
Pro Ala Asp His Pro Ala Arg Tyr Pro Ala Thr Ala Ser Gly Trp Ala 
        1075                1080                1085            
Val Leu Cys Ser Met Cys Arg Gly Gly Thr Asp Pro Asp Leu Phe Leu 
    1090                1095                1100                
Pro Gly Leu Gln Trp Met Asp Gly Thr Thr Gly Ala Gly Gly His Tyr 
1105                1110                1115                1120
Ala Asn Pro Tyr Glu Asn Ala Arg Tyr Phe Ala Ala Thr Thr Ala Arg 
                1125                1130                1135    
Leu Tyr Arg Asp Gly Thr Glu Ile Pro Arg Ser Asn Ala Asp Asp Pro 
            1140                1145                1150        
Leu Ala Leu Ile Pro Glu Phe Arg Leu Ala Pro Thr Pro Ala Thr Tyr 
        1155                1160                1165            
Arg Leu Asp Val Thr Asp Val Leu Pro Gly Gln Ala Gln Val Gly Ile 
    1170                1175                1180                
Pro Ser Gly Ala Leu Phe Gln His Ala Pro Arg Thr Asp Thr Ser Trp 
1185                1190                1195                1200
Thr Phe Ala Ser Ala Arg Ser Asp Ala Ala Ala Pro Leu Gly Phe Ser 
                1205                1210                1215    
Cys His Asn Ala Gly Lys Ser Cys Ser Phe Gln Pro Leu Ile Gln Leu 
            1220                1225                1230        
Asp His Arg Leu Pro Leu Asp Leu Gly Gly Arg Ala Pro Ala Gly Arg 
        1235                1240                1245            
Pro Phe Thr Phe Asp Val Ser Ala Gly Ser His Ser Gly Ala Arg Gly 
    1250                1255                1260                
Gly Gly Pro Val Thr Arg Leu Gln Val Ser Ala Ser Thr Asp Gly Gly 
1265                1270                1275                1280
Arg Thr Trp Thr Ala Ala Thr Val Arg Pro Gly Ala Asn Gly Leu Trp 
                1285                1290                1295    
Ser Val Thr Val Ala His Pro Pro Leu Ala Ala Thr Asp Gly Phe Val 
            1300                1305                1310        
Trp Leu Arg Ser Glu Ala Arg Asp Ser Ser Gly Asn Thr Val Thr Gln 
        1315                1320                1325            
Thr Val Gln Arg Ala Tyr Ala Leu Thr Asp Val Ala Lys Ala Asn Pro 
    1330                1335                1340                
Arg Ala Arg 
1345        

<210> 30
<211> 4044
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1653


<400> 30
atgttccccc gttcccctca cctgacgaga cacccctggc acccggtggc gatcctggcg       60

gcctccgcac tggtcgccct caccccctta ccggtgatcg cgaccgccgc gaccgccgcc      120

gtatccggcc ccgctcccgt caccgggcgg ccggacgtcc atcgcgtcac gttgctcacc      180

ggcgacgtgg tgacctacga acgagacggc gccgggcacg gcaccgcaca ggtcgaaccg      240

gcggtgcggc cggaccggcc gagcccggcg ttccagatca cgaccacggc cgaagggctg      300

atggtgtatc cgtcggacgc gcttccgttc gtcggcaagg gactgctgag cccggacctg      360

ttcaacgtca ccacgctcgt cggagaccgg cgtgacgacg cggcgagcac cacgatcccc      420

gtcatcgtgc gttacggcga ccggtcgggg ctgtccgccc ggactctgga cgcgaaggcg      480

aaggcgctcc cgcagaccca gcggctcacc ccgctggtca cggccaacgg agtgggggtt      540

caggtcaaga aagcggggac gggcgaattc tggcgttccc tcgtcgcgtt cgatgcgagc      600

gggaaacccg ttttgaacca agggatttcg caagtccggc tggacaggaa ggtccgggtg      660

acgctggaca agagcaccgc gcgggtcggt gcgccgtcgg cgtggagcgg tgggtggacc      720

gggaagggga ccacggtcgc ggtggtggac accgggatcg acgagaacca tcccgacctg      780

gcgggcaaga cggtcgcctc cgcggacttc agcggcgagg gcgacgtcgt ggaccgccac      840

ggccacggca cgcacgtcgc gtcgatcgtc gccggtaccg gcgcggcatc gggcggccgg      900

tacaagggtg tggcaccgga cgcgaatctg gtggtggcca aggttttcga cgcgtccggc      960

gagggtgaca ccgcacaggt gatggccggg atcgactggg ccgtcgcgca gggcgcgaag     1020

atcgtgaacc tcagcctcgg cgccggcgtc agcgacgggg ccgacccgat gagcgagcag     1080

atcgactcgc tttcggcgaa gtccggcacg ctgttcgtgg tcgcggccgg gaactcgggg     1140

ccgggcgacc ggacagtcac gacaccgggg gcggcgacgt ccgcgctcac cgtcggagcg     1200

ctcgaccggg aggacaagat cgcgtggttc agcagccgcg gcccgcggtt gcgggacgcc     1260

tcggtcaaac cggagatcac cgcgcccggc gtcgggatcg tcgccgccag ggctgcggac     1320

acggcgctgg gcgaaccggt ggacgactcc tacaccgccg cgtcgggcac ctcaatggcg     1380

acaccgcatg tcgcgggcgc cgcggcgatc ctgctgcagc agcgaccggg actgaccggg     1440

caggcactga agaacaccct cgtcaccacg gccaaggacg tcggtcttca ctggttcgag     1500

cagggcgccg gaatcctcga cgtcgcgcgg gccgtgtctc agaaggcgac cggcaccgcc     1560

gtcgcgagct tcggccgcaa cgaacggacg accaacgcct cggcacaggt cgtccggcag     1620

ctgtcctaca ccaacaccgg ggaccagccg ctgaacctca acctgaagct gaccgtgcga     1680

ccttgggacg gcggcgccgc gccgggtacc gggatgcgcc tggcgaagac ggatctgtcg     1740

atcccgccga agtcgagtac caccgtcgac ctcgccgtga acccgaacga aggaacggcg     1800

ggcgtctacg gcggcgccgt ggtggccacg accgcggacg ggaccaacgc ggtgcggact     1860

cccgtgagca cctacaacgc ggccgaactg ttcccggtga cgatccgggt ccgggactcg     1920

gcgggcgggc ccgctcagtc cgcgtcggcc cagctgatcg acgacgcggc cggtgcgggt     1980

aaccgcaacg acccgttcct cgaccaggtc agccagcagg tcggcctggt ggacggggtc     2040

ggccgggtgc tcgtgccagc cggacgctat tcggcgctcg gctgggtgat ggagcgcggg     2100

ctgacggtgc gccgctggtc ggcgatgagc gcgacgcagg tcgctgtcag cggcccggcg     2160

gagatcgcgc tgaacgcggc gaacgccgtc ccggcggggc tgatcacgcc cactcccacc     2220

gatctgcggg atcgcacggt gatgctgcgg cgcgtgatcc ccggcggagc cggtgtgaac     2280

ggttacgtcg gcgaagccgg gctggcttcg ggcgcgggct gggaggtgcg cgtgaccccc     2340

gcggccgcca cctcggcggg cgcgatttcg ttgcaggaca gcgcgacact gtcccagacc     2400

gcggtcgaga tgcggatcgt cggtggcggt ccggccgtgc tgaacccggc gtacgacgtg     2460

ccgacgttga cggcgaagtc gcccggtgag cgaacgctgc cggtcgtgtt cggtggcgcg     2520

ggtgatctca ccggtctcga cgtccgcgga aaggccgtcc tggtaaggat tccggtcccg     2580

gccggggcac cggacccggt gagcgcggtc tccgcgggca tcgcgaacgc ttcacgcgcg     2640

gtgtccgccg cgggtggggc ggcgttgatc ccctacgccg gttctccggg ttcgctgagc     2700

gttccgggtc tcagcagcgc ggtggtgccg accttgtccc tcggctggga cgaaggcgaa     2760

aagttgcgga ccgccggtgc cgtttcggtg cgcttgctgg tgcgctcggc tccggacgcg     2820

atgtacaacc tcagctatct cgacgccaac ggcgtgccga aggagctcgt ccggcgggtc     2880

gaccagaaga ccttggtcgc cacgaaaacc ggctaccagg ccgaaaaacc gggactgacc     2940

ggacagaaga actggtacgc cttcccgacc ggcctgtgga agacacaggc ggtgcagggc     3000

acgaagatcc cggttcccgg ctcctggacc gaatacaccg gcccggcgaa cgatcggctg     3060

gtctggaaac gggtcgtcac cctgtccggc aacgacaccg cggggcgccg cgccgcgctg     3120

agcatgaacg cgcagaacgt ctaccgcgcg ggcgagcggt cgagaccgga cgagttctgg     3180

ttccgcgcgc cactgcacag cggcacggtg gaactgcccg ccgatcatcc ggcccggtac     3240

ccggcgacgg cctccggctg ggcggtgctg tgctcgatgt gccgtggtgg cacggatccc     3300

gacctgttcc tccccggcct gcagtggatg gacggcacga ccggggcggg cgggcattac     3360

gcgaatccct acgagaacgc gcggtacttc gcggcgacca cggcacggct gtaccgggac     3420

gggaccgaga tcccgcggtc caatgcggac gatccgctcg cgctcatccc ggagttccgg     3480

ctcgcgccga cccccgccac ctaccggctg gacgtgaccg acgtgctgcc cggccaggcg     3540

caggtcggca tcccgagcgg ggcgctgttc cagcacgccc cgaggacgga cacgtcgtgg     3600

acgttcgcct cggcgcggtc agacgccgcg gcaccgctcg gcttctcctg ccacaacgcg     3660

ggcaagtcgt gttccttcca gccactcatc cagctggacc accggttgcc gctcgatctc     3720

ggcggccgcg ccccggccgg acgcccgttc accttcgacg tgtccgccgg ctcgcacagc     3780

ggcgcgcggg gcggcggacc ggtgacgcgg ctgcaggtgt cggcgtcgac ggacggcggg     3840

cgtacctgga cggcggcgac cgtccggccg ggcgcgaacg ggctgtggtc ggtgacggtg     3900

gcccacccgc cactcgcggc gacggacggg ttcgtctggc tgcgctcgga agcacgggac     3960

agctcgggca acaccgtgac gcagacggtc cagcgggcct acgcgctcac ggacgtggcg     4020

aaggcgaacc cgcgcgctcg ctga                                            4044


<210> 31
<211> 197
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1654

<400> 31
Met Leu Ala Met Gly Met Ala Gly Gly Val Ala Asn Ala Ala Gly Glu 
1               5                   10                  15      
Ser Glu Gly Thr Glu Ala Ala Pro Leu Val Ser Ser Thr Val Val Ile 
            20                  25                  30          
Asn Glu Val Ser Thr Arg Gly Val Asn Gly Leu Leu Asp Glu Phe Ile 
        35                  40                  45              
Glu Leu Arg Asn Val Ser Asn Gln Pro Gln Asp Val Ser Gly Tyr Val 
    50                  55                  60                  
Ile Arg Ile Tyr Ser Pro Ser Asn Val Val Thr Asp Thr Ile Val Leu 
65                  70                  75                  80  
Pro Ala Gly Thr Ile Leu Gln Pro Lys Gly Asn Ala Gly Gln Tyr Ala 
                85                  90                  95      
Val Leu Val Gly Gln Asn Phe Ser Gly Thr Val Val Asp Gln Thr Tyr 
            100                 105                 110         
Val Ile Pro Phe Thr Leu Thr Gly Ala Glu Gly Ile Pro Thr Ala Gly 
        115                 120                 125             
Gly Leu Ser Leu Gln Asn Met Ala Ala Ala Lys Ile Asp Gly Val Ala 
    130                 135                 140                 
Phe Ser Asn Ala Val Val Ala Pro Arg Glu Gly Gln Ala Ala Ile Pro 
145                 150                 155                 160 
Glu Asn Val Ile Thr Asp Gln Leu Asn Ala Ala Asn Thr Arg Asn Ile 
                165                 170                 175     
Leu Ser Thr Asp Thr Asp Asn Asn Arg Gln Asp Phe Ser Leu Gln Leu 
            180                 185                 190         
Arg Thr Pro Gly Leu 
        195         

<210> 32
<211> 594
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1654


<400> 32
atgctggcga tgggtatggc cggtggtgtc gcgaacgcgg caggcgagag cgagggcacc      60

gaggccgccc cgctcgtgtc gtccaccgtg gtcatcaacg aggtttcgac ccgcggcgtg     120

aacggtctgc tcgacgagtt catcgagctg cgcaacgttt cgaaccagcc gcaggacgtg     180

agcggctacg tgatccggat ctactcgccg tcgaacgtcg tgaccgacac gatcgtcctg     240

ccggcgggca cgatcctgca gccgaagggc aacgcgggcc agtacgcggt gctcgtcggg     300

cagaacttct ccggcaccgt cgtcgaccag acctacgtca tccccttcac cctgaccggc     360

gccgagggca tcccgacggc cggtggcctt tcgctgcaga acatggcggc cgcgaagatc     420

gacggtgtgg ccttcagcaa cgccgtcgtg gccccgcgtg aaggccaggc cgcgatcccg     480

gagaacgtca tcaccgatca gctcaacgcg gcgaacaccc gcaacatcct gagcaccgac     540

accgacaaca accggcagga cttctcgctg cagctgcgca ccccgggtct gtaa           594


<210> 33
<211> 94
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1655

<400> 33
Met Thr Ala Asn Ser Glu Arg Gly Ala Ala Ala Pro Leu Cys Glu Leu 
1               5                   10                  15      
Leu Ala Glu Gln Arg Ile Ala Lys Gly Trp Ser Gln Gly Asp Leu Val 
            20                  25                  30          
Val Lys Leu His Thr Arg Ser Gly Asn Asp Ser Val Thr Arg Glu Glu 
        35                  40                  45              
Ile Ser Arg Trp Glu Arg Gly Lys Arg Ile Pro Gly Pro Tyr Trp Arg 
    50                  55                  60                  
Gln Trp Leu Ser Asp Val Leu Asp Thr Ser Ser Arg Glu Leu Glu Leu 
65                  70                  75                  80  
Ala Ala Ala Val Ala Arg Arg Arg Arg Arg Asn Ile Ile Ala 
                85                  90                  

<210> 34
<211> 285
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1655


<400> 34
gtgaccgcga acagcgaacg cggggccgcg gccccgcttt gcgaactgct cgccgaacaa     60

cgaatcgcga aaggatggtc acaaggcgat ctggtcgtga agttgcacac ccgctccggc    120

aacgacagtg tcaccaggga agagatttcc cgctgggagc ggggaaaacg cattcccggt    180

ccctattggc ggcagtggct cagcgatgtg ctggacacct ccagccgcga gctcgaactc    240

gccgccgcgg tcgcgagaag gcggcgccgg aacattatcg cgtga                    285


<210> 35
<211> 166
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1656

<400> 35
Met Thr Lys Pro Gly Ser Leu Phe Leu Leu Leu Ala Leu Ala Gly Thr 
1               5                   10                  15      
Pro Ala Pro Asp Thr Val Arg Ala Ser Ser Ala Lys Ile His Glu Val 
            20                  25                  30          
Leu Gly Gly Pro Ala Gly Tyr Ile Asp Leu His Asn Thr Gly Ala Thr 
        35                  40                  45              
Thr Leu Asp Ile Gly Gly Trp Ser Val Gln Ala Cys Thr Gly Gly Ala 
    50                  55                  60                  
Thr Pro Val Glu Leu Ala Ala Met Pro Ala Gly Ser Glu Ile Pro Ala 
65                  70                  75                  80  
Gly Asp His Phe Leu Ile Thr Ala Gln Gly Phe Gly Gly Thr Met Gln 
                85                  90                  95      
Gln Val Val Val Glu Ala Ile Val Gly Asp Gly Glu Ile Leu Leu Asp 
            100                 105                 110         
Arg Arg Gly Ala Arg Val Asp Ser Val Gly Trp Ala Pro Ser Ser Pro 
        115                 120                 125             
Cys Arg Glu Asn Gln Ala Ala Val Ser Cys Pro Gly Leu Ala Gln Ser 
    130                 135                 140                 
Arg Asp Ala Val Ser Arg Asp Thr Asp Asn Asn Lys Ala Asp Phe Gly 
145                 150                 155                 160 
Cys Val Arg Pro Ala Gly 
                165     

<210> 36
<211> 501
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1656


<400> 36
atgacgaagc caggttccct gttcctgctc ctcgcactcg ccggaacccc ggccccggac      60

accgtccggg cttcgtcggc caagatccac gaggtgctcg gcggcccggc aggctacatc     120

gacctgcaca acaccggcgc caccaccctt gacatcggcg gctggtccgt tcaggcgtgc     180

acgggcgggg cgacacccgt cgaactggcc gccatgcccg ccgggagcga gatccccgcc     240

ggtgaccatt tcctcatcac cgcacagggt ttcggcggga cgatgcagca ggtggtcgtc     300

gaggctatcg tcggggacgg cgagatactg ctggaccggc gcggggcgag ggtcgacagc     360

gtcggatggg cgccgtcgtc gccctgccgc gagaaccagg ccgccgtctc ctgccccggg     420

ctcgcccagt cgagggacgc cgtcagccgc gacaccgaca acaacaaggc cgacttcggc     480

tgtgtacggc cggccggctg a                                               501


<210> 37
<211> 231
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1657

<400> 37
Met Asn Arg Val Thr Thr Leu Val Val Asp Asp Gln Pro Leu Ile Arg 
1               5                   10                  15      
Tyr Ala Leu Ser Arg Leu Leu Arg Asp Ser Ala Gly Val Gly Ala Val 
            20                  25                  30          
Ala Glu Ala Ala Ser Glu Pro Glu Ala Leu Trp Gln Cys Glu Lys Ser 
        35                  40                  45              
His Pro Asp Met Val Ile Thr Glu Leu Ser Ile Trp Gly Glu Pro Ala 
    50                  55                  60                  
Gly Thr Ala Ile Cys Arg Phe Val Lys Glu Gln Phe Glu Arg Ala Ala 
65                  70                  75                  80  
Val Leu Val Phe Ala Gly Asp Ser Ser Pro Ser Ala Ile Ala Met Ala 
                85                  90                  95      
Leu Asn Ala Gly Ala Asp Ser Phe Val His Lys Ser Ala Ser Gly Gly 
            100                 105                 110         
Gln Val Met Ser Ala Val Arg Ser Thr Leu Ala Gly Gln Arg Val Cys 
        115                 120                 125             
Leu Gln Ala Gly Gly Thr Pro Pro Ala Val Thr Glu Ala Val Arg Tyr 
    130                 135                 140                 
Ala Ser Ala Met Thr Arg Arg Glu Glu Glu Ile Leu Ala Leu Ile Leu 
145                 150                 155                 160 
Tyr Arg Trp Ser Asn Asp Glu Ile Ala Glu Glu Leu His Leu Ala Thr 
                165                 170                 175     
Gln Thr Val Lys Asn Tyr Val Ser Arg Ile Leu Gln Lys Leu Gly Phe 
            180                 185                 190         
Gly Ser Arg Arg Asp Leu Phe Arg Ala Leu Arg Phe Arg Pro Gly Gly 
        195                 200                 205             
Asn Leu Leu Pro Arg Leu Glu Thr Thr Glu Arg Glu Gly Glu Leu His 
    210                 215                 220                 
Thr Ala Asp Gly Tyr Arg Gly 
225                 230     

<210> 38
<211> 696
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1657


<400> 38
atgaaccgcg tcaccacgct cgtagtagac gatcaacccc tcatcagata cgcgctcagc      60

aggctgttgc gggattcggc gggggtgggg gcggtggccg aagccgcgag tgagcctgaa     120

gcgttgtggc agtgcgaaaa gagccatccc gacatggtca tcaccgagct gtcgatctgg     180

ggtgagcctg ccgggaccgc gatctgccgg ttcgtgaagg aacagttcga acgcgctgcc     240

gtcctggtct tcgccggtga ttcgtcgcca tcggccatcg cgatggcgct gaacgcgggt     300

gcggacagct tcgtgcacaa gtcggccagc ggcggccagg tgatgtcggc ggtgcgctcg     360

acgctcgccg ggcagcgggt gtgcctgcag gcgggcggaa ccccgccggc ggtcaccgag     420

gccgtgcgct acgcgagcgc gatgaccaga cgggaggagg agatcctcgc gctgatcctc     480

taccggtggt cgaacgacga gatcgccgag gaactgcatc tcgccacgca gaccgtgaag     540

aactacgtca gccggatcct gcagaagctg ggcttcggca gcagacgcga cctcttccgg     600

gcgctgcgtt tccggccggg cggaaacctg ttgccgcgcc tggagacgac cgagcgcgaa     660

ggcgagttgc acacggcgga cgggtaccgg ggctag                               696


<210> 39
<211> 139
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1658

<400> 39
Met Asp Asp Ser Tyr Arg Leu Glu Ala Gly Ser Pro Ser Val Asp Asp 
1               5                   10                  15      
Tyr Leu Arg Leu Arg Arg Glu Ala Gly Leu Ser Glu Pro Pro Arg Glu 
            20                  25                  30          
Gln Ala Glu Arg Gly Val Arg Gly Ala Trp Thr Ser Val Arg Val Val 
        35                  40                  45              
His Arg Pro Thr Gly Glu Thr Val Gly Met Gly Arg Val Ile Ser Asp 
    50                  55                  60                  
Gly Gly Trp Tyr Phe His Ile Val Asp Met Ala Val Leu Pro Ala His 
65                  70                  75                  80  
Gln Arg Arg Gly Ile Gly Asp Ala Val Leu Glu Ala Leu Leu Ala Ala 
                85                  90                  95      
Ile Asp Thr Ala Ala Pro Gly Ala Tyr Val Asn Leu Leu Gly Asp Pro 
            100                 105                 110         
Pro Gly Trp Arg Leu Tyr Lys Arg His Gly Phe Val Glu Thr Ala Pro 
        115                 120                 125             
Gly Thr Ile Gly Met Arg Arg Gln Asn Ala Gly 
    130                 135                 

<210> 40
<211> 420
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1658


<400> 40
atggacgact cttaccgcct ggaagcaggc tccccgtcgg tcgacgacta cctgcggctg      60

cgccgcgagg ccggtctcag cgaaccgccg agggaacagg cggagcgcgg ggttcgcggc     120

gcctggacgt cggtccgggt ggtccaccgg cccaccggcg agaccgtcgg gatgggccgg     180

gtgatcagcg acggtgggtg gtacttccac atcgtcgaca tggccgttct gcccgcccat     240

cagcgccgcg gcatcgggga cgccgtcctc gaggcccttc tcgcggcgat cgacaccgcg     300

gcgccgggtg cgtacgtcaa tctgctcggc gatccacccg gatggcggct ctacaaacgc     360

cacggtttcg tggagaccgc tcccgggacc atcggcatgc ggcgccaaaa cgccggataa     420


<210> 41
<211> 174
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1659

<400> 41
Met Thr Val Thr Thr Leu Arg Pro Gly Leu Pro Glu Leu Ile Lys Arg 
1               5                   10                  15      
Leu Arg Gln Cys Thr Gly Arg Pro Ser Glu Pro Leu Val Thr Ala Gln 
            20                  25                  30          
Ala Val Ala Asn Val Leu Thr Glu Leu Arg Pro Thr Pro Gln Leu Leu 
        35                  40                  45              
Thr Ala Thr Glu Arg Ala Gly Ser Pro Asp Gly Tyr Thr Arg Thr Thr 
    50                  55                  60                  
Leu His Ala Glu Ser Ala Phe Ser Ile Val Gly Leu Val Trp Arg Pro 
65                  70                  75                  80  
Gly Gln Leu Thr Glu Ile His Asp His Leu Val Trp Cys Thr Phe Leu 
                85                  90                  95      
Val Leu Gln Gly Thr Glu Thr Glu Thr Ile Phe Asp Ile Asp Asp Asp 
            100                 105                 110         
Arg Leu Val Arg Lys Ala Gln Arg Gln Arg Pro Ala Gly Ser Val Ser 
        115                 120                 125             
Gly Val Ala Pro Pro Asp Asp Ile His Gln Val His Asn Ala Gly Asp 
    130                 135                 140                 
Thr Val Ala Ile Thr Leu His Val Tyr Gly Ala Asp Leu Ser Lys Gly 
145                 150                 155                 160 
Thr Ser Val Arg Arg Asn Tyr Arg Met Arg Ala Thr Ser Arg 
                165                 170                 

<210> 42
<211> 525
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1659


<400> 42
atgaccgtca cgaccctcag accaggcctt ccggagctga tcaaacgtct gcgccaatgc      60

accggaagac catccgaacc ccttgtcacc gcacaagccg tggcgaacgt tctcaccgaa     120

ctccgcccga ctccgcaact gctcaccgcg acggaacgcg ccggctcccc cgacggctac     180

acccgcacca ccctgcacgc cgagtccgcc ttttcgatcg tcggactggt ctggcggccc     240

ggtcagctca ccgagatcca cgatcacctg gtgtggtgta cattccttgt cctgcaagga     300

accgagaccg agaccatctt cgacatcgac gacgatcggc tggtccggaa ggcccagcgg     360

caacgcccgg cggggtcggt gagcggcgtc gcgccgcccg acgacatcca ccaggtgcac     420

aacgcgggcg acaccgtcgc catcaccttg cacgtgtacg gcgccgacct gagcaaggga     480

accagcgtgc gccgcaatta ccggatgcgc gccacttcgc ggtga                     525


<210> 43
<211> 288
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1660

<400> 43
Met Leu Asn Leu Val Gln Leu Thr Val Leu Ala Ala Val Ala Arg His 
1               5                   10                  15      
Gly Ser Met Thr Ala Ala Ala Lys Glu Leu His Tyr Thr Gln Pro Ala 
            20                  25                  30          
Val Ser His His Leu Ala Arg Leu Glu Ala Ala Thr Gly Ala Lys Leu 
        35                  40                  45              
Val Gln Arg Ile Gly Arg Gly Ile Arg Leu Thr Pro Glu Gly Glu Leu 
    50                  55                  60                  
Leu Ala Ala Arg Ala Ala Glu Ile Val Gly Arg Val Glu Gly Ala Glu 
65                  70                  75                  80  
Ala Glu Leu Ala Ala Gln Val Gly Leu Arg Ala Gly Arg Val Arg Met 
                85                  90                  95      
Ala Gly Phe Gln Ser Ile Leu Ser Thr Ile Val Pro Asp Ala Ala Ala 
            100                 105                 110         
Thr Leu Ala Arg Ala His Pro Gly Leu Glu Leu Gly Leu Val Asp Glu 
        115                 120                 125             
His Pro Gly Glu Ala Leu Arg Met Leu Arg Glu Gly Arg Ile Asp Val 
    130                 135                 140                 
Ala Leu Ile Phe Arg Tyr Ala Asp Thr Pro Arg Glu Glu Gln Gly Leu 
145                 150                 155                 160 
Arg Leu Val His Leu Leu Glu Asp Pro Ile Tyr Leu Leu Thr Ser Glu 
                165                 170                 175     
Pro Gly Gln Thr Ile Ala Asp His Arg Asp Ser Thr Trp Ile Gly Gly 
            180                 185                 190         
Cys Ala Arg Cys Gln Asp Glu Leu Val Thr Ile Cys Gly Arg Ala Gly 
        195                 200                 205             
Phe Ala Pro Arg Ile Ser Met Val Ser Asp Asp Ile Val Val Met Gln 
    210                 215                 220                 
Ala Leu Val Ala Ala Arg Met Gly Val Thr Thr Leu Pro Arg Leu Ala 
225                 230                 235                 240 
Leu Arg Ala His Arg Met Pro Gly Val His Ala Thr Glu Leu Ala Glu 
                245                 250                 255     
Asp Pro Arg Gln Ile Tyr Ala Val Thr Tyr Gly Asp Pro Pro Asp Pro 
            260                 265                 270         
Pro Ala Ala Ala Ala Leu Ile Asp Ala Leu Gln Thr Ser Ile Arg Ala 
        275                 280                 285             



<210> 44
<211> 867
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1660


<400> 44
atgctgaatc tggtgcagct cacggtgctg gcggcggtcg cgcggcacgg ttcgatgacc      60

gcggcggcga aggaactgca ctacacgcag cccgcggtga gccaccatct cgcgaggttg     120

gaggcggcga cgggcgcgaa gctggtccag cggatcggcc gcggcatccg gctcacaccg     180

gaaggggaac tgctcgccgc ccgcgcggcc gagatcgtcg gccgggtcga aggcgccgaa     240

gccgagttgg ccgcgcaggt gggcttgcgc gccgggcggg tccggatggc ggggttccag     300

tcgatcctga gcacgatcgt ccccgacgcg gccgcgacgc tggcccgtgc gcatcccgga     360

ctcgaactcg ggctggtgga cgaacatccg ggcgaggcgc tgcgcatgct gcgggagggg     420

cggatcgacg tcgccctgat cttccggtac gcggacacgc cccgcgagga acaggggctc     480

cggctcgtgc acctgctgga ggacccgatc tacctgctca ccagcgaacc ggggcagacc     540

atcgccgatc atcgtgactc gacctggatc ggcggctgcg cccgatgcca ggacgaactc     600

gtcacgatct gcgggcgggc cgggttcgcc ccgcgtattt cgatggtcag cgacgacatc     660

gtggtcatgc aggcgctggt cgcggcccgg atgggcgtca ccacgctgcc ccggctggcg     720

ctgcgtgcgc atcggatgcc cggtgtgcac gccacggagc tggccgaaga cccgcgtcag     780

atctatgccg tcacctatgg cgacccgccc gatcctccgg ccgcagcggc gttgatcgac     840

gcgcttcaga cgagcatccg ggcttag                                         867


<210> 45
<211> 411
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1661

<400> 45
Met Arg His Leu Asn Ala Ile Gly His Leu Ala Pro His Asp His Ala 
1               5                   10                  15      
Ala Ala Pro Ala Gly Pro Leu Ser Gly Ile Pro Leu Val Val Lys Asp 
            20                  25                  30          
Asn Ile His Val Ala Gly Met Pro Asn Thr Ala Gly Thr Pro Ala Leu 
        35                  40                  45              
Ala Gly His Val Pro Arg Glu His Ala Thr Val Val Arg Arg Leu Thr 
    50                  55                  60                  
Asp Ala Gly Ala Val Val Val Gly Lys Ala Thr Met His Glu Leu Ala 
65                  70                  75                  80  
Leu Gly Ile Thr Cys Asp Thr Thr Pro Leu Gly Pro Val Arg Asn Ala 
                85                  90                  95      
Cys Asp Pro Ser Arg Phe Ala Gly Gly Ser Ser Gly Gly Thr Ala Val 
            100                 105                 110         
Ala Val Ala Ala Gly Ile Val Pro Ala Gly Leu Gly Thr Asp Thr Gly 
        115                 120                 125             
Gly Ser Ala Arg Val Pro Ala Ala Leu Asn Gly Val Cys Gly Phe Arg 
    130                 135                 140                 
Pro Thr Thr Gly Arg Tyr Pro Ser Asp Gly Met Thr Pro Leu Ser Ser 
145                 150                 155                 160 
Thr Arg Asp Thr Ala Gly Pro Ile Ala Arg Thr Val Ala Asp Leu Ala 
                165                 170                 175     
Leu Leu Asp Ala Val Leu Ala Ala Glu Glu Pro Thr Pro Leu Ile Glu 
            180                 185                 190         
Ser Thr Ser Val Arg Leu Gly Val Pro His Gly Phe Leu Thr Gly Asp 
        195                 200                 205             
Leu Ser Glu Asp Val Glu Glu Leu Trp Glu Ala Ala Leu Ala Arg Leu 
    210                 215                 220                 
Gly Ala Ala Gly Val Thr Leu Val Pro Leu Asp Asp Thr Pro Leu Ala 
225                 230                 235                 240 
Glu Leu Val Val Asp Gln Gly Met Pro Leu Val Ile His Glu Ala Gly 
                245                 250                 255     
Val Gly Leu Arg Ser Tyr Leu Ala Glu His Val Pro Glu Val Ser Phe 
            260                 265                 270         
Glu Arg Leu Val Arg Glu Ile Ala Ala Pro Asp Val Arg Ala Ile Phe 
        275                 280                 285             
Ala Glu Ala Val Val Pro Gly Val Glu Pro Ala Val Tyr Glu Ala Ala 
    290                 295                 300                 
Ile Thr Thr Arg Ser Ala Leu Arg Arg Ala Tyr Ala Lys Ile Phe Asp 
305                 310                 315                 320 
Glu Ser Gly Ile Asp Ala Leu Ala Phe Pro Thr Thr Pro Ala Thr Ala 
                325                 330                 335     
Arg Asp Phe Ser Ala Val Gly Ser Phe Val His Arg Gly Arg Glu Val 
            340                 345                 350         
Pro Thr Phe Pro Thr Phe Ile Arg Asn Cys Gln Pro Gly Ser Ile Ala 
        355                 360                 365             
Gly Phe Pro Gly Leu Thr Val Pro Met Gly Arg Ala Arg Asp Gly Leu 
    370                 375                 380                 
Pro Ala Gly Leu Ala Leu Asp Gly Leu Val Gly Asp Asp Arg Lys Leu 
385                 390                 395                 400 
Leu Gly Val Gly Ala Phe Val Glu Arg Val Leu 
                405                 410     

<210> 46
<211> 1236
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1661


<400> 46
gtgcggcatc tcaacgcgat cggccacctg gcgccgcacg atcacgcggc cgcgccggcc      60

ggcccgctca gcgggatccc gttggtggtc aaggacaaca tccacgtcgc cgggatgccg     120

aacaccgcgg gtaccccggc gctggcgggc cacgttccgc gcgagcacgc gaccgtggtc     180

cgacggctga ccgacgcggg cgccgtcgtc gtcggcaagg cgaccatgca cgaactcgcc     240

ctcggcatca cctgcgacac gaccccgctc ggcccggtgc gcaacgcgtg cgacccgtcc     300

cggttcgccg ggggcagcag cggcgggacc gcggtcgccg tcgcggcggg catcgtgccc     360

gcgggtctgg gcaccgacac cggcggttcg gcccgtgttc ccgccgcgct caacggggtt     420

tgcggcttcc ggccgaccac gggccgctac ccgtccgacg gcatgacgcc gctgagcagc     480

acgcgggaca cggccgggcc gatcgcccgc acggtcgccg atctcgcgct cctcgacgcg     540

gtcctcgcgg cggaagagcc gacacccctg atcgagagca cgtcggtcag gctgggtgtg     600

ccgcacggtt tcctgaccgg cgacctgtcc gaggacgtcg aagaactctg ggaagccgcg     660

cttgcccgct tgggcgcggc aggcgtcacc ctggtgccgc tcgacgacac gccgctcgcc     720

gaactcgtcg tcgatcaggg aatgccgctg gtgatccacg aagcaggcgt cgggctccgc     780

tcctacctcg ccgagcacgt acccgaggtt tcgttcgagc ggctcgttcg cgagatcgcc     840

gcgcccgacg tccgggcgat cttcgccgaa gcggtcgtgc cgggcgtcga acccgccgtc     900

tacgaagcgg ccatcaccac ccgctccgcc ttgcgtcgcg cctacgcgaa gatcttcgac     960

gagagcggca tcgacgcgct ggccttcccc accacaccgg cgacggcccg ggacttctcg    1020

gccgtcggga gcttcgtgca ccgagggcgc gaggtcccga ccttccccac cttcatccgc    1080

aactgccagc ccggcagtat cgcgggattc cccggcctga ccgtcccgat ggggcgcgca    1140

cgcgacggcc tgcccgccgg gctggcgctc gacggcctgg tcggggacga ccggaagttg    1200

ctgggcgtgg gggctttcgt cgaacgggtt ctgtag                              1236


<210> 47
<211> 327
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1662

<400> 47
Met Ser Ser Gly Pro Ser Leu His Val Leu Thr Arg Ser Asp Leu His 
1               5                   10                  15      
Ser Leu Glu Leu Thr Pro Gly Glu Ala Ile Thr Met Val Glu Asp Gly 
            20                  25                  30          
Tyr Leu Ala Tyr Ala Ala Gly Ala Ser Arg Asn Pro Ala Lys Leu Met 
        35                  40                  45              
Val Pro Ile Pro Asp Pro Ala Arg Asp Ala Val Ala Tyr Ser Met Leu 
    50                  55                  60                  
Gly Tyr Asp Gly Ser Leu Glu Gln Ala Ala Phe Lys Thr Ser Tyr Arg 
65                  70                  75                  80  
Gln Gly Ser Thr Ser Ala Glu Lys Tyr Tyr Thr Thr Ile Thr Leu Tyr 
                85                  90                  95      
Asp Asp Thr Thr Gly Leu Pro Phe Ala Leu Met Asp Cys His Arg Val 
            100                 105                 110         
Gly Ala Thr Arg Thr Pro Ala Ser Thr Ala Leu Ile Ala Arg Ser Cys 
        115                 120                 125             
Ala Arg Pro Gly Ala Arg Ser Ala Leu Met Val Gly Thr Gly Ala Gln 
    130                 135                 140                 
Gly Ile Arg Thr Leu Pro Tyr Leu Leu Thr Ala Leu Pro Glu Leu Glu 
145                 150                 155                 160 
Arg Leu Arg Leu Phe Gly Thr His Pro Asp Gly Leu Arg Asp Ser Val 
                165                 170                 175     
Ala Ala Leu Lys Glu Arg Phe Pro Asp Arg Glu Val Glu Leu Val Asp 
            180                 185                 190         
Asp Val Glu Ala Ala Ala Arg Glu Ser Asp Ile Val Val Ala Ala Ser 
        195                 200                 205             
Gly Arg Ala Ala His Pro Lys Ile Arg Leu Gly Trp Leu Pro Pro Gly 
    210                 215                 220                 
Gly Leu Leu Ile Ser Val Ala Ser Lys Gly Val Gln Glu Gly Thr Leu 
225                 230                 235                 240 
Ala Glu Ala Asp Tyr Thr Val Ala Thr Ser Gly Ala Gln Val Glu Val 
                245                 250                 255     
Thr Gly Gln Arg Met Ala Gly Pro Asp Gly Val Phe Arg Ile Asp Ala 
            260                 265                 270         
Glu Leu Pro Glu Ile Leu Ala Gly Lys Ala Pro Gly Arg Arg Gly Asp 
        275                 280                 285             
Glu Asp Arg Val Phe Ala Phe Ser Ser Gly Met Ile Ile Thr Asp Ile 
    290                 295                 300                 
Pro Val Ala His Ala Leu Ala Ala Arg Ala Ile Ala Ala Gly Arg Gly 
305                 310                 315                 320 
Arg Glu Val Ala Leu Trp Thr 
                325         

<210> 48
<211> 984
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1662


<400> 48
atgagctccg gtccctcgct gcacgtactc acgcgctcgg atctgcacag cctcgaactc      60

acccctggcg aggcgatcac gatggtcgaa gacggctatc tggcctacgc ggccggggcc     120

tcgcggaacc cggcgaagct gatggtgccg atcccggatc ccgcgcggga cgccgtcgcg     180

tactcgatgc tcggctacga cggttccctc gaacaggccg cgttcaagac gagctaccgc     240

caaggcagca cgtcggccga gaagtactac acgaccatca ccctgtacga cgacaccacg     300

ggcctgccgt tcgcgctcat ggactgccac cgcgtcggcg ccacccgcac gcccgcgagc     360

accgcgttga tcgcgcggtc ctgcgctcgg ccgggcgcgc gatccgcgct catggtcggc     420

accggcgcgc aggggatccg gacgctgccg tacctgctca ccgcgctgcc ggagctggaa     480

cggctgcggc tgttcggcac gcatcccgac ggtcttcgcg acagcgtcgc cgcgctgaag     540

gagcgcttcc cggaccgcga ggtcgaactc gtcgacgacg tggaggccgc ggcgcgcgag     600

tccgacatcg tggtcgccgc gtcgggccgg gcggcccacc cgaagatccg tctcggctgg     660

ctgccgccgg gcgggctgct gatctccgtc gccagcaagg gagtccagga aggcacgctc     720

gccgaggccg actacacggt ggccaccagc ggcgcgcagg tcgaggtgac cgggcagcgg     780

atggcgggtc cggacggcgt gttccggatc gacgccgaac tcccggagat cctcgcgggc     840

aaggcccccg gccgccgcgg cgacgaagac cgggtgttcg ccttcagcag cggcatgatc     900

atcaccgaca tcccggtggc gcacgcgctg gccgcccgcg ccatcgccgc cggccgcggc     960

cgcgaggtgg ccctgtggac ctga                                            984


<210> 49
<211> 448
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1663

<400> 49
Met Asp Leu Ile Asp Thr Leu Ser Pro Pro Leu Pro Ala Leu Glu Arg 
1               5                   10                  15      
Pro Trp Ala His Arg Leu Arg Ala Ser Glu Thr Leu Trp Glu Ile Ala 
            20                  25                  30          
Arg Gly Val Gly Gly Gly Pro Phe His Val Val His Pro Ala Thr Phe 
        35                  40                  45              
Ala Glu Asn Leu Gly Glu Met Val Asp Ala Leu Ala Ala Glu Arg Val 
    50                  55                  60                  
Glu Gly Thr Val Tyr Tyr Gly Lys Lys Ala Asn Lys Ala Ala Ala Trp 
65                  70                  75                  80  
Leu Arg Glu Cys Thr Arg Pro Gly Thr Gly Val Asp Val Ala Ser Val 
                85                  90                  95      
Pro Glu Leu Val His Ala Leu Gly Asn Gly Leu Arg Gly Glu Ala Ile 
            100                 105                 110         
Gly Val Thr Gly Ala Ala Lys Pro Asp Gly Leu Leu Trp Leu Ala Leu 
        115                 120                 125             
Arg His Arg Cys Leu Ile Ala Val Asp Ala Ala Asp Glu Leu Glu Arg 
    130                 135                 140                 
Val Ala Arg Leu Ala Thr Glu Leu Gly Glu Thr Ala Glu Val Leu Leu 
145                 150                 155                 160 
Arg Val Arg Pro Pro Ser Ala Pro Glu Ser Arg Phe Gly Phe Ala Pro 
                165                 170                 175     
Asp Ala Val Lys Ala Ala Val Arg Gln Cys Gly Gly Pro Val Val Leu 
            180                 185                 190         
Arg Gly Phe Ser Phe His Leu Asp Gly Tyr Asp Pro Val Pro Arg Ala 
        195                 200                 205             
Glu Leu Ala Ala Tyr Leu Ile Asp Leu Cys His Asp Ala Arg Ala Leu 
    210                 215                 220                 
Gly His Pro Ala Ser Lys Ile Ser Ala Gly Gly Gly Ile Ala Val Ser 
225                 230                 235                 240 
Tyr Val Asp Ala Gly Asp Trp Ala Arg Phe Glu Ser Gly Arg His Asp 
                245                 250                 255     
Gly Trp Phe His Ala Gly Arg Asn Pro Ala Arg Thr Tyr Pro Tyr His 
            260                 265                 270         
Gln Ala Pro Thr Gly Ala Ala Met Val Thr Ala Ile Leu Arg His Glu 
        275                 280                 285             
Ile Ala Gly Lys Thr Leu Ala Glu Arg Leu Arg Ala Ala Gly Ile Glu 
    290                 295                 300                 
Leu Leu Leu Glu Pro Gly Arg Ala Leu Val Asp Gly Ala Gly Phe Ser 
305                 310                 315                 320 
Val Phe Pro Val Leu Gly Cys Lys Pro Ala Glu Asp His Leu Ile Thr 
                325                 330                 335     
Thr Val Ala Gly Leu Ser Met Ser Leu Ser Glu Gln Trp Lys Gly Ser 
            340                 345                 350         
Glu Phe Leu Pro Asp Pro Leu Leu Val Arg Arg Asp Gly Pro Gly Gly 
        355                 360                 365             
Thr Pro Val Arg Thr Ile Val Ala Gly Ser Ser Cys Met Glu Tyr Asp 
    370                 375                 380                 
Val Leu Thr Trp Arg Ala Val Glu Leu Pro Ala Gln Pro Arg Thr Gly 
385                 390                 395                 400 
Asp Leu Leu Val Tyr Pro Asn Thr Ala Gly Tyr Gln Met Asp Lys Asn 
                405                 410                 415     
Glu Ser Gly Phe His Gln Leu Pro Leu Pro Pro Lys Val Val Val Asp 
            420                 425                 430         
Gly Asp Arg Trp His Leu Asp Thr Asp His Pro Ile Gln Glu Ile Arg 
        435                 440                 445             



<210> 50
<211> 1347
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1663


<400> 50
gtggacctga tcgacaccct gtccccgccc ctgcccgcgc tcgaacgtcc ctgggcgcac      60

cggctgcgtg cttcggagac gctgtgggag atcgcccgcg gggtcggcgg cggcccgttc     120

cacgtggtcc atccggccac tttcgccgag aacctcgggg aaatggtcga cgcgctcgcc     180

gccgaacggg tcgaaggcac cgtctactac gggaagaagg cgaacaaggc ggcggcctgg     240

ctgcgggaat gcacgcgtcc cggcacgggg gtcgacgtcg cgagtgtgcc cgaactggtg     300

cacgccctcg gaaacgggct gcgcggcgaa gcgatcgggg tcaccggcgc cgccaaaccc     360

gacggcctcc tttggctcgc cctgcggcat cgctgtctca tcgcggtgga cgcggccgac     420

gagctggaac gcgtcgcccg gctggccacc gaactcgggg agaccgccga agtgctgctg     480

cgagtgcggc cgccgtccgc gccggagagc cggttcggtt tcgcgcccga cgcggtgaaa     540

gcggccgtgc gacagtgcgg cggcccggtc gtcctgcggg gtttctcgtt ccacctcgac     600

ggctacgacc ccgtgccgag ggcggaactc gccgcatacc tgatcgatct gtgtcacgac     660

gcccgcgcgc tcggacatcc cgcgtcgaag atcagtgcgg gcggcgggat cgctgtgtcc     720

tatgtggacg ccggtgactg ggcgcggttc gagtccggca ggcacgacgg ctggttccac     780

gccggccgta atccggccag gacctatcca taccaccagg cgccgaccgg ggcggcgatg     840

gtgaccgcga tcctccggca cgagatcgcc gggaagacac tggccgagcg cctgcgcgcg     900

gccgggatcg agctgctgct cgaaccgggc cgagccctcg tcgacggcgc cgggttctcg     960

gtgttcccgg tgctgggctg caaaccggcc gaagaccacc tgatcaccac ggtcgcgggc    1020

ctgtccatga gcctgtccga acagtggaag ggcagcgagt tcctgcccga cccgctgctc    1080

gtgcgcaggg acggaccggg cggtacgcca gtgcggacca tcgtcgcggg gtcgagctgc    1140

atggagtacg acgtgctgac ctggcgcgcg gtggagctgc ccgcgcaacc gaggaccggc    1200

gacctgctcg tgtaccccaa cacggccggc taccagatgg acaagaacga gagcggtttc    1260

caccagcttc cgttgccgcc gaaagtggtg gtcgacggcg accgctggca cctcgacacc    1320

gaccacccga tccaggagat ccgatga                                        1347


<210> 51
<211> 352
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1664

<400> 51
Met Thr Ile Val Arg Arg Ala Ser Asp Leu Ile Gly Asn Thr Pro Leu 
1               5                   10                  15      
Leu Glu Leu Ala Arg Thr Gly Thr Gly Thr Arg Leu Leu Leu Lys Leu 
            20                  25                  30          
Asp His Leu Asn Pro Thr Gly Ser Cys Lys Val Arg Met Ala Arg Gln 
        35                  40                  45              
Met Ile Asp Glu Ala Glu Leu Asp Gly Arg Leu Arg Pro Gly Gly His 
    50                  55                  60                  
Ile Val Glu Pro Thr Ser Gly Asn Thr Gly Asn Gly Leu Ala Leu Val 
65                  70                  75                  80  
Ala Leu Glu Arg Gly Tyr Arg Phe Thr Ala Val Val Asp His His Ala 
                85                  90                  95      
Ala Arg Glu Lys Leu Gly Met Leu Arg Ala Leu Gly Ala Glu Leu Val 
            100                 105                 110         
Phe Val Glu Cys Pro Pro Asp Gly Gly Val Ser Ser Val Gln Arg Arg 
        115                 120                 125             
Arg Val Ala Ala Arg Ile Ala Ala Glu Thr Gly Ala Tyr His Pro Asp 
    130                 135                 140                 
Gln His Asn His Pro Gly Asn Gly Asn Gly Tyr Thr Gly Leu Ala Arg 
145                 150                 155                 160 
Glu Leu Val Glu Gln Leu Gly Asp Val Asp Val Leu Val Ala Ala Ile 
                165                 170                 175     
Gly Thr Gly Gly Ser Leu Cys Gly Thr Ala Arg Ala Leu Arg Ala Ala 
            180                 185                 190         
Gly Ala Ser Thr His Ala Val Ala Val Glu Pro Val Gly Ser Ile Ile 
        195                 200                 205             
Phe Gly Gly Ala Pro Gly Ile Tyr His Gln Thr Gly Ala Gly Ser Pro 
    210                 215                 220                 
Ala Gly Phe Pro Ile Gly Asp Asn Val Asp Arg Ser Val Ile Gly Glu 
225                 230                 235                 240 
Ala His Arg Val Ser Asp Ser Asp Ala Phe Ala Gly Ala Arg Val Val 
                245                 250                 255     
Ala Arg Arg Thr Gly Val Leu Val Gly Gly Thr Thr Gly Gly Ala Ile 
            260                 265                 270         
His Val Ala Leu Arg Arg Leu Tyr Ala Tyr Pro Ala Gly Ser Val Val 
        275                 280                 285             
Val Val Leu Cys Asn Asp Ala Gly Glu Lys Tyr Leu Asp Ser Val Tyr 
    290                 295                 300                 
Asp Asp Glu Trp Leu Arg Ala Arg Gly Val Leu Asp Glu Leu Ala His 
305                 310                 315                 320 
Arg Arg Met Asp Arg Trp Phe Ala Thr Tyr Ala Glu Ser Val Lys Val 
                325                 330                 335     
Ala Thr Arg Asp Arg Ala Val Arg Arg Thr Pro Val Ala Val Gly Gly 
            340                 345                 350         



<210> 52
<211> 1059
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1664

<400> 52
atgacgatcg tccggcgcgc gtccgacctg atcgggaaca cgccgctgct ggagctcgcg      60

cgtaccggca ccgggacgcg tctgctgctc aaactcgacc acctcaaccc caccggctcg     120

tgcaaggtac gcatggcgag gcagatgatc gacgaggcgg agctggacgg acggctgcgg     180

ccgggcgggc atatcgtcga acccacgtcc ggcaacaccg ggaacgggct cgccctggtc     240

gcgctggaac gcggctaccg gttcaccgcc gtggtcgatc accacgccgc ccgcgagaaa     300

ctcgggatgc tgcgcgcgct cggcgcggaa ctggtgttcg tcgaatgccc gccggacggc     360

ggggtcagtt cggtccagcg gcggcgggtc gcggcccgca tcgccgcgga aaccggtgcc     420

taccatcccg atcagcacaa ccatcccggc aacggcaacg ggtacaccgg gctggcgcgg     480

gaactcgtcg agcagctcgg cgacgtcgac gtgctcgtcg cggcgatcgg caccggcggc     540

tccctgtgcg gtacggcccg cgccctgcgc gcggcgggag cgagcaccca cgcggtggcg     600

gtcgaacctg tcggctcgat catcttcggt ggtgcgccgg ggatctacca ccagaccggg     660

gcgggcagcc cggccggttt cccgatcggg gacaacgtcg accggtcggt gatcggcgaa     720

gcccaccgcg tttccgacag cgacgcgttc gccggggccc gcgtcgtcgc caggcgcacc     780

ggcgtgctgg tcggcgggac caccggcggc gcgatccacg tcgcgctgcg gcggctttac     840

gcgtatccgg ccggaagcgt cgtcgtggtg ctgtgcaacg acgcggggga gaagtacctc     900

gattcggtgt acgacgacga atggctgcgc gccaggggcg tactcgacga actggcccac     960

cgccggatgg accgctggtt cgccacctac gccgaatccg tgaaggtcgc cacgcgcgac    1020

cgggcggtgc gccggacccc ggtggcggtg ggcggatga                           1059


<210> 53
<211> 460
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1665

<400> 53
Met Ser Thr Ala Val Thr Thr Arg Gly Tyr Arg Ala Leu Ala Gly Leu 
1               5                   10                  15      
Ala Ala Pro Ile Ala Gly Ile Gln Leu Ala Gln Val Ala Leu Thr Ser 
            20                  25                  30          
Val Asp Leu Ala Met Leu Gly Leu Leu Gly Val Thr Ala Val Ala Ala 
        35                  40                  45              
Gly Gly Leu Ala Ile Leu Leu Tyr Asn Gln Ile Arg Thr Met Cys Val 
    50                  55                  60                  
Gly Met Val Thr Gly Val Gly Asn Leu Val Ala Thr Ala Ala Gly Ala 
65                  70                  75                  80  
Gly Glu Leu Arg Thr Gly Thr Gly Glu Leu Asp Glu Arg Ala Arg Asp 
                85                  90                  95      
Glu Ile Arg Ser Leu Leu Arg Ser Ala Leu Leu Val Ala Thr Leu Thr 
            100                 105                 110         
Ala Ala Leu Gly Ala Ala Val Leu Cys Gly Leu Ala Val Ala Leu Pro 
        115                 120                 125             
Ser Leu Gly Gln Lys Pro Glu Ile Val Ser Leu Ala Gly Pro Met Met 
    130                 135                 140                 
Phe Ala Leu Ala Gly Gly Leu Phe Pro Met Val Trp Leu Asn Val Val 
145                 150                 155                 160 
Arg Gln Phe Ala Val Gly Leu Arg Arg Pro Gly Ser Leu Leu Ala Val 
                165                 170                 175     
Thr Leu Val Ser Ile Ala Val Asn Ala Ala Leu Asn Ala Ala Phe Ile 
            180                 185                 190         
Tyr Gly Trp Ala Gly Leu Pro Glu Leu Gly Val Ala Gly Ile Gly Leu 
        195                 200                 205             
Ala Thr Thr Leu Val Gln Phe Phe Thr Leu Ala Val Phe Ala Ser Ala 
    210                 215                 220                 
Leu Arg Arg Asp Pro Leu Leu Arg Pro Met Val Ser Leu Ala Leu Trp 
225                 230                 235                 240 
Arg Ala Asp Arg Ala Val Val Arg Arg Ile Val Arg His Gly Thr Pro 
                245                 250                 255     
Ile Cys Phe Thr Tyr Gly Ser Glu Ala Ala Ile Thr Ser Ile Ala Thr 
            260                 265                 270         
Met Leu Met Gly Ala Phe Gly Pro Ala Met Leu Ala Ala Ser Asn Val 
        275                 280                 285             
Ala Asn Gln Leu Ala Tyr Ile Val Tyr Gln Ala Asn Ile Gly Leu Ser 
    290                 295                 300                 
Gln Gly Ser Ser Ile Leu Val Ser Arg Ala Val Ala His Gly Asp Arg 
305                 310                 315                 320 
Asp Arg Ala Pro Val Ile Ala Arg Gln Ala Phe Thr Leu Ser Trp Ser 
                325                 330                 335     
Leu Met Ala Val Val Ser Leu Ala Tyr Leu Leu Val Pro Gln Val Leu 
            340                 345                 350         
Leu Trp Pro Phe Leu His Asp Glu Thr Asp Ala Val Val Leu Gly Thr 
        355                 360                 365             
Ala Ser Thr Leu Leu Val Phe Ala Ile Ala Gln Gln Tyr Ser Lys Gly 
    370                 375                 380                 
Thr Gln Asn Ile Leu Val Gly Leu Leu Arg Gly Leu Gly Asp Thr Val 
385                 390                 395                 400 
Ser Gly Leu Arg Cys Thr Leu Val Gly Tyr Trp Ala Val Gly Val Pro 
                405                 410                 415     
Ala Met Phe Leu Cys Ala Tyr Val Phe Ala Trp Gly Gly Trp Gly Val 
            420                 425                 430         
Trp Ala Gly Leu Cys Leu Gly Phe Ala Thr Thr Ala Val Leu Leu Gly 
        435                 440                 445             
Arg Ser Phe Ala Gly Gln Gly Ala Gly Ser Ala Arg 
    450                 455                 460 

<210> 54
<211> 1383
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1665


<400> 54
atgagcacgg cggtgacgac ccgcggctac cgggccctcg ccgggctggc cgcgccgatc      60

gcgggaatcc agctggcaca ggtcgcgctc accagcgtcg acctggccat gctcgggctg     120

ctcggggtga ccgcggtggc ggcgggcggg ctggcgatcc tgctctacaa ccagatccgc     180

accatgtgcg tcggcatggt caccggcgtc gggaacctcg tggcgacggc ggccggggcc     240

ggggaactcc gcaccggcac cggcgaactc gacgagcggg cgcgggacga gatccggtcg     300

ctcctgcggt cggcgctgct cgtcgcgacc ctgaccgcgg cgctcggcgc ggccgtcctt     360

tgtggactgg ccgtcgcgct gccttcgctc ggccagaaac cggagatcgt ttcgctcgcc     420

ggtccgatga tgttcgcact ggccggcggg ctgttcccga tggtgtggct gaacgtggtg     480

cgccagttcg ccgtcgggtt gcggcggccg ggttcgctcc tcgccgtgac gctggtgtcg     540

atcgcggtca acgccgccct caacgccgcc ttcatctacg gctgggcggg tctgcccgag     600

ctgggcgtcg ccggtatcgg cctggcgacg accttggtcc agttcttcac gctcgccgtg     660

ttcgcctcgg ccctccggcg ggacccgctg ttgcgcccca tggtgtcgct cgcgctgtgg     720

cgcgcggatc gggcggtggt ccggcgcatc gtccggcacg ggacgccgat ctgcttcacc     780

tacggctcgg aggcggcgat cacctcgatc gcgacgatgc tgatgggtgc gttcggcccg     840

gcgatgctcg ccgcgtcgaa cgtcgcgaac cagctcgcct acatcgtcta ccaggccaac     900

atcgggctgt cgcaaggatc gtccattttg gtcagccgcg cggtcgccca cggtgaccgg     960

gatcgcgcac cggtgatcgc gcgccaggcg ttcaccctct cctggtcctt gatggcggtg    1020

gtgagcctgg cgtacctgct ggtgccgcag gtgctgctgt ggccgttcct gcacgacgag    1080

accgacgcgg tggtgctcgg cacggcgtcg accctgctgg tgttcgccat cgcgcagcag    1140

tacagcaagg gaacgcagaa catcctcgtc ggcctgctgc gcgggctcgg tgacaccgtc    1200

tccggcctcc gctgcacgct cgtggggtac tgggcggtgg gcgtgcccgc gatgttcttg    1260

tgcgcctacg tgttcgcctg gggcggctgg ggggtctggg ccgggctgtg tctcggcttc    1320

gcgacgaccg cggtcctgct cggacggagt ttcgccggtc agggagccgg ttctgcgcga    1380

tag                                                                  1383


<210> 55
<211> 313
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1666

<400> 55
Met Thr Thr Thr Gly Arg Ile Gly Ile Ala Asp Val Glu Cys Leu Glu 
1               5                   10                  15      
Asn Ala Val Asp Thr Leu Arg Ala Leu Asp Tyr Arg Gln Gly Gly Ala 
            20                  25                  30          
Phe Ser His Asp Ala Val His Val Val Lys Ser Val Ser Leu Leu Leu 
        35                  40                  45              
Thr Trp Gly Ala Val Pro Gly Gly Leu Arg Ser Arg Leu Leu Thr Val 
    50                  55                  60                  
Leu Ala Asp Leu His Asn Leu Leu Gly Trp Thr Glu Phe Asp Ile Gly 
65                  70                  75                  80  
Arg Arg Val Pro Ala Arg Leu Arg Phe Asp Arg Ala Leu Gly Leu Ala 
                85                  90                  95      
Ala Ala Ala Gly Asn Asp Asn Leu Met Ala Asn Ile Cys Tyr Arg Leu 
            100                 105                 110         
Gly Arg Leu Ala Leu His His Asp Asp Val Glu Gly Gly Leu Asp His 
        115                 120                 125             
Leu Arg Gln Gly Gln Ala Ala Ala His Arg Ser Gly Ser Leu Arg Ala 
    130                 135                 140                 
Gln Ala Ile Leu Thr Ile Asn Glu Ala Trp Ala Leu Ala Lys Ala Gly 
145                 150                 155                 160 
Asp Glu Arg Ala Ala Leu Thr Ser Leu Ala Arg Ala Glu Cys Glu Phe 
                165                 170                 175     
Glu Asn Ala Gly Thr Trp Ala Ala Pro Arg Pro Trp Glu Ala Phe Phe 
            180                 185                 190         
Gly Ala Thr Asp Met Ala Ala Met Arg Gly Thr Val Leu Thr Glu Leu 
        195                 200                 205             
Ala Arg Thr Val Ala Ser Arg His Ser Glu Glu Ala Ile Glu Arg Leu 
    210                 215                 220                 
Arg Asp Ala Val Asp Gly Tyr Gly Ala Glu Met Ser Arg Ser Leu Ala 
225                 230                 235                 240 
Leu Thr Leu Ile Met Leu Ala Gln Asn His Ala Leu Gln Gly Asp Phe 
                245                 250                 255     
Gly Glu Ala Val Arg Thr Gly Asp Glu Ala Leu Asp Leu Ala Arg Gly 
            260                 265                 270         
Leu Gly Ser Thr Arg Thr Lys Asp Arg Leu Ala Pro Leu Ala Ala Leu 
        275                 280                 285             
Leu Arg Gly Asp Ala Asp Pro Ala Ser Arg Asp Leu Leu Ala Arg Ile 
    290                 295                 300                 
Asp Arg Tyr Arg Ala Glu Pro Ala Pro 
305                 310             

<210> 56
<211> 942
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1666


<400> 56
atgacaacga ccggccgtat cggtatcgcc gacgtcgaat gtctcgaaaa cgcggtcgat      60

actctgcgcg cgttggacta tcggcagggc ggcgcctttt cccacgacgc ggtgcacgtc     120

gtgaagtcgg tcagcctgct gctcacttgg ggcgccgtcc ccggcggact ccggtcacgg     180

ttgctgaccg tgctcgcgga tctgcacaat ctgctgggct ggacggaatt cgacatcggc     240

cgccgcgttc cggcacggct ccggttcgac cgcgcgctcg gtctcgccgc cgcggcgggc     300

aacgacaatc tcatggccaa catctgttac cgcctcggca ggctggcgtt gcatcatgac     360

gacgtcgaag gcgggttgga ccatctccgg caaggccaag ccgccgccca ccgctccggt     420

tccctgcggg cccaggcgat cctgacgatc aacgaggcgt gggcactggc caaggccggt     480

gacgagcgcg cggccctcac gagcctggcg cgggcggagt gcgagttcga gaacgcgggc     540

acctgggcgg cgccacgacc gtgggaagcc ttcttcggcg ccacggacat ggccgcgatg     600

cgcgggaccg tcctgaccga attggccagg acggtcgcct cccggcacag cgaagaagcg     660

atcgagcggt tacgcgacgc cgtcgacggc tacggcgccg agatgtcccg cagcctcgcg     720

ctcaccttga tcatgctcgc gcagaaccac gcgctccagg gcgacttcgg cgaagccgtc     780

cgcaccggcg acgaggcgct ggacctcgcg cggggcctcg gttccacccg caccaaggac     840

cggctcgcac cgctggcggc acttctgcgc ggagacgccg atcccgcctc ccgcgacctg     900

ctcgcccgga tcgaccgcta tcgcgcagaa ccggctccct ga                        942


<210> 57
<211> 140
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1667

<400> 57
Met Ser Asp Phe Glu Ala Gln Leu Arg Ala Val Ser Leu Arg Val Thr 
1               5                   10                  15      
Arg Pro Arg Leu Ala Val Leu Ala Ala Leu Arg Asp His Pro His Val 
            20                  25                  30          
Asp Thr Glu Thr Val Ile Ala Leu Val Arg Ala Asp Leu Pro Thr Val 
        35                  40                  45              
Ser His Gln Ala Val Tyr Asp Val Leu Arg Ala Leu Thr Glu Thr Gly 
    50                  55                  60                  
Leu Ile Arg Arg Ile Gln Pro Ala Gly Ala Leu Ala Arg Tyr Glu Thr 
65                  70                  75                  80  
Arg Val Gly Asp Asn His His His Val Val Cys Arg Ser Cys Gly Ala 
                85                  90                  95      
Ile Ala Asp Val Asp Cys Ala Val Gly His Ala Pro Cys Leu Thr Ala 
            100                 105                 110         
Ser Gly Asp His Gly Phe Val Ile Asp Glu Ala Glu Val Val Tyr Trp 
        115                 120                 125             
Gly Leu Cys Pro Gly Cys Ala Ala Glu Pro Val Gln 
    130                 135                 140 

<210> 58
<211> 423
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1667


<400> 58
atgtccgact tcgaggcaca gctgcgagcg gtttcgttgc gcgtgacgcg gcctcggctg      60

gccgtgctcg cggcgctgcg cgatcatccg cacgtcgaca ccgaaacggt gatcgcgctg     120

gtgcgggccg atctgccgac ggtctcgcac caggcggtgt acgacgtgct gcgggcgctc     180

accgaaaccg gtctgatccg gcggatccag cccgccggcg cgctcgcccg ttacgagacc     240

cgggtggggg acaaccatca ccatgtcgtg tgccgttcct gcggtgcgat cgcggacgtc     300

gattgcgccg tcggccatgc cccctgtctc accgcttcgg gcgatcacgg gttcgtgatc     360

gacgaggcgg aggtcgtcta ctggggcctg tgccccggct gtgcggccga acctgtccag     420

tga                                                                   423


<210> 59
<211> 744
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 1668

<400> 59
Met Ser Asp Asn Pro Glu Lys Gly Cys Pro Val Ala His Asp Ser Val 
1               5                   10                  15      
Thr Ala His Gly Ser Glu Ser Glu Asn Pro Ala Ile Asp Ser Pro Thr 
            20                  25                  30          
Pro Lys Ser Gly Gly Arg Pro Arg Thr Asn Lys Asp Trp Trp Pro Asn 
        35                  40                  45              
Gln Leu Asp Leu Ser Val Leu His Ala His Ser Ser Lys Ser Asn Pro 
    50                  55                  60                  
Leu Gly Ala Asp Phe Ser Tyr Ala Lys Glu Phe Ala Lys Leu Asp Val 
65                  70                  75                  80  
Glu Ala Leu Lys Arg Asp Ile Thr Glu Val Leu Thr Thr Ser Gln Asp 
                85                  90                  95      
Trp Trp Pro Ala Asp Phe Gly His Tyr Gly Gly Leu Met Ile Arg Met 
            100                 105                 110         
Ser Trp His Ala Ala Gly Thr Tyr Arg Ile His Asp Gly Arg Gly Gly 
        115                 120                 125             
Ala Gly Asp Gly Ala Gln Arg Phe Ala Pro Leu Asn Ser Trp Pro Asp 
    130                 135                 140                 
Asn Ala Asn Leu Asp Lys Ala Arg Arg Leu Leu Trp Pro Val Lys Glu 
145                 150                 155                 160 
Lys Tyr Gly Gln Gln Ile Ser Trp Ala Asp Leu Leu Val Leu Ala Gly 
                165                 170                 175     
Asn Val Ala Leu Glu Ser Met Gly Phe Lys Thr Phe Gly Phe Gly Phe 
            180                 185                 190         
Gly Arg Val Asp Thr Trp Glu Pro Glu Glu Ile Phe Trp Gly Pro Glu 
        195                 200                 205             
Asp Thr Trp Leu Gly Asp Glu Arg Tyr Ala Ser Asp Thr Glu Met Val 
    210                 215                 220                 
Pro Asp Val Gly Ala Thr Glu Met Gly Leu Ile Tyr Val Asn Pro Glu 
225                 230                 235                 240 
Gly Pro Arg Gly Asn Ala Asp Pro Ala Ala Ala Ala His Phe Ile Arg 
                245                 250                 255     
Glu Thr Phe Ala Arg Met Ala Met Asn Asp Glu Glu Thr Val Ala Leu 
            260                 265                 270         
Ile Ala Gly Gly His Thr Phe Gly Lys Thr His Gly Ala Gly Ile Ala 
        275                 280                 285             
Asp Asp His Val Gly Pro Glu Pro Glu Ala Ala Pro Leu Glu Thr Gln 
    290                 295                 300                 
Gly Leu Gly Trp Leu Ser Thr His Gly Ser Gly Lys Gly Ala Asp Ala 
305                 310                 315                 320 
Ile Thr Ser Gly Leu Glu Val Thr Trp Thr Asp Lys Pro Thr Gln Trp 
                325                 330                 335     
Ser Asn Arg Phe Phe Glu Ile Leu Phe Gly Tyr Glu Trp Glu Leu Thr 
            340                 345                 350         
Thr Ser Pro Gly Gly Ala Lys Gln Tyr Val Ala Lys Asp Ala Glu Ala 
        355                 360                 365             
Ile Ile Pro Asp Ala His Asp Pro Ala Lys Lys His Lys Pro Thr Met 
    370                 375                 380                 
Leu Thr Thr Asp Leu Ala Leu Arg Val Asp Pro Glu Tyr Glu Lys Ile 
385                 390                 395                 400 
Ser Arg Arg Phe Leu Glu Asn Pro Asp Asp Phe Ala Leu Ala Phe Ala 
                405                 410                 415     
Lys Ala Trp Tyr Lys Leu Leu His Arg Asp Met Gly Pro Val Ser Arg 
            420                 425                 430         
Phe Leu Gly Pro Trp Val Pro Glu Pro Gln Leu Trp Gln Asp Pro Val 
        435                 440                 445             
Pro Asp Val Asp His Glu Leu Val Gly Asp Ala Asp Ile Ala Ala Leu 
    450                 455                 460                 
Lys Thr Lys Val Leu Glu Ser Gly Leu Thr Val Glu Gln Leu Val Gly 
465                 470                 475                 480 
Thr Ala Trp Ala Ser Ala Ala Ser Phe Arg Ser Thr Asp Lys Arg Gly 
                485                 490                 495     
Gly Ala Asn Gly Ala Arg Ile Arg Leu Ala Pro Gln Arg Asp Trp Glu 
            500                 505                 510         
Val Asn Arg Pro Glu Glu Leu Ala Ser Val Leu Glu Thr Leu Glu Gly 
        515                 520                 525             
Ile Gln Arg Glu Phe Asn Asp Ala Gly Gly Ala Lys Ile Ser Leu Ala 
    530                 535                 540                 
Asp Leu Ile Val Leu Ala Gly Thr Ala Ala Val Glu Lys Ala Ala Arg 
545                 550                 555                 560 
Asp Ala Gly Thr Asp Val Thr Val Ala Phe His Pro Gly Arg Thr Asp 
                565                 570                 575     
Ala Thr Gln Glu Asp Thr Asp Val Glu Ser Phe Thr Leu Leu Glu Pro 
            580                 585                 590         
Arg Ala Asp Gly Phe Arg Asn His Leu Arg Pro Glu Glu Lys Leu Gln 
        595                 600                 605             
Pro Glu Val Leu Leu Val Glu Arg Ala Tyr Met Leu Asp Leu Thr Ala 
    610                 615                 620                 
Pro Glu Met Thr Val Leu Val Gly Gly Leu Arg Ala Leu Gly Ile Thr 
625                 630                 635                 640 
Ala Gly Asp Thr Arg His Gly Val Leu Thr Asp Arg Pro Gly Val Leu 
                645                 650                 655     
Thr Asn Asp Phe Phe Thr Asn Leu Leu Ser Pro Gly Thr Arg Trp Lys 
            660                 665                 670         
Val Ser Glu Ser Glu Glu Asn Val Tyr Glu Ile Arg Asp Ala Gly Thr 
        675                 680                 685             
Asp Ala Val Lys Trp Thr Ala Thr Pro Val Asp Leu Val Phe Gly Ser 
    690                 695                 700                 
Asn Ser Gln Leu Arg Ala Leu Ser Glu Val Tyr Ala Gly Gln Ala Gly 
705                 710                 715                 720 
Arg Glu Arg Phe Ala Ala Asp Phe Ala Lys Ala Trp Thr Lys Val Met 
                725                 730                 735     
Glu Leu Asp Arg Phe Asp Leu Asp 
            740                 

<210> 60
<211> 2235
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 1668


<400> 60
atgagtgaca acccggagaa gggctgcccg gtggcccacg actccgtgac cgcgcacgga      60

agtgagagcg agaacccggc gatcgactcg ccgacgccga aatcgggcgg ccgcccgcgt     120

accaacaagg actggtggcc caaccagctc gacctctcgg tgctgcacgc ccactcgtcg     180

aagtcgaacc cgctcggcgc ggacttcagc tacgccaagg aattcgccaa actcgacgtc     240

gaggccctca aacgcgacat caccgaggtg ctcaccacct cgcaggactg gtggcccgca     300

gacttcggcc actacggcgg cctgatgatc cggatgagct ggcacgccgc gggcacctac     360

cgcatccacg acggccgagg cggcgccggt gacggcgcgc agcggttcgc cccgctcaac     420

agctggcccg acaacgccaa cctcgacaag gcacggcggc tgctgtggcc ggtcaaggag     480

aagtacggcc agcagatctc gtgggccgac ctgctcgtgc tcgccgggaa cgtcgcgctg     540

gagtcgatgg ggttcaagac gttcggcttc ggtttcggcc gcgtggacac ctgggagccc     600

gaggagatct tctggggtcc ggaagacacc tggctgggtg acgagcgcta cgcgagcgac     660

accgagatgg tccccgacgt cggcgcgacc gaaatgggcc tcatctacgt caaccccgag     720

ggaccccgag gcaacgcgga cccggccgcc gcggcgcatt tcatccggga gaccttcgcc     780

cggatggcga tgaacgacga ggagaccgtc gcgctcatcg ccgggggcca caccttcggc     840

aagacccacg gtgccggtat cgccgacgac cacgtcggcc cggaacccga agccgccccg     900

ctcgagacac agggcctcgg ctggctgagc acccacggca gcggcaaggg cgccgacgcg     960

atcaccagcg gtctcgaggt gacgtggacc gacaagccga cgcagtggag caaccggttc    1020

ttcgagatcc tcttcggcta cgaatgggaa ctcaccacca gcccgggcgg cgccaagcag    1080

tacgtcgcca aggacgccga ggcgatcatc ccggacgccc acgacccggc caagaagcac    1140

aagccgacca tgctcaccac ggatctcgcg ctgcgcgtcg acccggagta cgagaagatc    1200

tcgcgccgct tcctggagaa cccggacgac ttcgcgctcg cgttcgccaa ggcctggtac    1260

aaactgctgc accgcgacat gggcccggtc agccgtttcc tggggccgtg ggtgcccgaa    1320

ccgcagctgt ggcaggaccc ggtgccggac gtcgaccacg aactcgtggg ggacgccgac    1380

atcgccgcgc tcaagacgaa ggtgctcgag tccgggctca cggtcgagca gctggtcggc    1440

acggcgtggg cgtccgcggc gagcttccgg tccaccgaca aacgcggcgg cgccaacggg    1500

gcccggatcc gcctggcacc ccagcgtgac tgggaggtca accggccgga agagctcgcg    1560

agtgtgctgg agaccctgga gggcatccag cgcgagttca acgacgccgg tggcgccaag    1620

atctcgctgg ccgacctgat cgtgctggcg ggcactgccg ccgtcgagaa ggcggcgcgc    1680

gacgcgggca ccgacgtgac cgtggcgttc caccccggcc gcaccgacgc cacccaggag    1740

gacaccgacg tcgagtcgtt cacgctgctc gaaccgcggg ccgacgggtt ccgcaaccac    1800

ctgcgtcccg aggagaaact gcagccggag gtcctgctgg tcgagcgcgc ctacatgctc    1860

gacctgaccg cgcccgagat gaccgtcctc gtcggcggcc tgcgtgcgct cgggatcacc    1920

gccggcgaca cccggcacgg cgtcctcacc gaccggcccg gcgtgctcac caacgacttc    1980

ttcaccaacc tcctctcgcc gggcacccgg tggaaggtgt cggagtccga ggagaacgtg    2040

tacgagatcc gcgacgccgg cacggacgcg gtgaagtgga cggcgacccc ggtcgacctc    2100

gtgttcggct ccaactcgca gctgagggcg ctttccgagg tctatgcggg tcaggccggg    2160

cgggagcggt tcgccgccga cttcgccaag gcgtggacca aggtcatgga actggaccgg    2220

ttcgacctcg actga                                                     2235


<210> 61
<211> 137
<212> PRT
<213> Amycolatopsis japonicum

<220> 
<223> ORF 5768

<400> 61
Met Ser Pro Thr Thr Ala Asn Ser Ser Ala Pro Val Pro Gly Arg Arg 
1               5                   10                  15      
Ser Thr Lys Gln Arg Ala Ala Val Val Glu Leu Leu Lys Glu Ile Asp 
            20                  25                  30          
Asp Phe Arg Ser Ala Gln Glu Leu His Asp Glu Leu Arg Lys Arg Gly 
        35                  40                  45              
Asp Gly Ile Gly Leu Thr Thr Val Tyr Arg Thr Leu Gln Ser Leu Ser 
    50                  55                  60                  
Glu Ala Gly Glu Ile Asp Val Leu Arg Thr Asp Thr Gly Glu Ala Ile 
65                  70                  75                  80  
Tyr Arg Arg Cys Ser Ser His His His His His Leu Val Cys Arg Leu 
                85                  90                  95      
Cys Gly Ser Thr Val Glu Val Glu Gly Pro Ala Val Glu Arg Trp Ala 
            100                 105                 110         
Glu Lys Ile Ala Ser Glu His Gly Phe Ser Asp Ile Ser His Thr Val 
        115                 120                 125             
Glu Ile Val Gly Thr Cys Ser Asn His 
    130                 135         

<210> 62
<211> 414
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> orf 5768


<400> 62
atgagtccga cgacggccaa cagttccgcg ccggtgccgg gacgccggtc gacgaaacag      60

cgggccgccg tggtcgagct gctcaaggag atcgacgact tccgttctgc ccaggaactg     120

cacgacgagc tgcgcaaacg cggcgacggc atcgggctca ccacggtgta ccggacgctg     180

cagtcgctgt ccgaggccgg cgagatcgac gtcctgcgca cggacaccgg cgaggccatc     240

taccggcgtt gctcgtcgca ccaccaccat cacctggtgt gccgtctctg cggcagcacg     300

gtcgaggtcg agggccccgc ggtggagcgg tgggccgaga agatcgcttc ggagcacggc     360

ttctccgaca tcagccacac cgtggagatc gtcgggacct gctcgaacca ctga           414


<210> 63
<211> 1869
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> ds orf 5768


<400> 63
aatcatatgg tcgggacctg ctcgaaccac tgacgagcgc tatgaaaggt cctttcctgg      60

caaattttgc aaggaaagga cctttcatag catcggctca gtactcgtaa gggtccttcg     120

gcgccggcac ctgccgcacc gaggtgagcg tcaaatccgg catgtagctg ttctcccgta     180

ccgcggtccc cggcacgacc gtcccggtga cctccagcca ggtgtcgttc ccgaagcccg     240

acacgccgtc gcccaccatc cgcacggtga tcgggaaggc gtcggccgcg cagcagccga     300

tgaccatccg cgccagcatc gtgttgccct cgttgtgcac gacgaagccg gacagccgca     360

ccgtgcgccc gttcaacgag ccactggaat cccatcccgc gcggctgacg aactcgttga     420

cctccagcgg gaccacgtcc ccggcgggca agggcgggaa ggcggccgcg ttgctcgccg     480

aagcgctctg tggcgccctg gcctcggtgc gggtcaccga atcggcgccc agcgcgggcg     540

gcgcgaccag gaacacggcc agcacgggca ccatcagcag ccaggccgag cgggtgttgt     600

ggtcgtgcgc gtggacatcg ccggacacga cggcggcggc ccgcgcggcc agcaggtcgc     660

ggacgatcgc gaccgcgccc agcgccacca tcaccgcgcc gcccgcgatg atccacggct     720

gctgggcggg tttgacgtag cgcaggtagt cgccgttgat cgtgatcttc agcagcgcgc     780

cgccgagcag gatcagcagg atgttctggg tctcgcgttt cacgcgccac ctccgaggat     840

caacacaccc gacacgacgg cgcacgacag cgcgaccacg aacgtcaccg gcgcgaaccg     900

gagcgcgaag gacttgccaa aggtgccggt ctgcagggcg aacagcttca cgtcgatcgc     960

gggcccgacc accaggaaca ccagtttcgg cagcagcggc atcgcggtca gcgacgcggc    1020

gacgaaggcg tcggcctcac tgcacagggc cagcacgacg gcgagcacgg ccatcaccag    1080

caccccgagc acgatctgct cccccagcac tccgaaccac ttggcgggca ccagcacgtt    1140

catcgcggcg gcgatcatcg cgccgagcac caggaaaccg ccggcctcga ccagatccgc    1200

ccgcgcggtc tcggcgaagg tcttccagcg cgaaccgtgc tgaacctccg gaagccgccg    1260

caaagcccgc tccgcgatcc agtcgagctt gccccacttc gcccacagcc agcccatcac    1320

catcgcggtg gcgagcgaac cggcgaagcg ggcgaacacc atttccgggt tcccggggaa    1380

cgccaccgcc gtcgcgacca gcaccaccgg gttcaccgcg ggcgcggcga gcaggaaggt    1440

cagcgcggcc gcgggcgcga cgccctggcc gatcaggcgc cgcgcgaccg gcaccgacgc    1500

gcattcacac ccggcagggc gaccccggcc agccccgcga cgccgacggc cgcaccggcc    1560

cggcgaggga gcaccttctc cagcacccgc gcgggcacga acgccgcgat cgcgccgctg    1620

atcagcaccc cgagcaccag gaacggcagc gcctgcacgc agacggcgac gaacacggtc    1680

gagccggtcc gcagcgcggg cacgtcgaac acctgctgga gccagctctg cccgaggatc    1740

gcgatcagca ggatcgcgca gagcacctcg atcgaggtga tcttgaaccg ccgggccggc    1800

ttcttctccg gggcgcttct ggaaatggtt tccatgcgcg cgatgatgcc aggtgaccgt    1860

tctagatta                                                            1869


<210> 64
<211> 1537
<212> DNA
<213> Amycolatopsis japonicum

<220> 
<223> us orf 5768


<400> 64
aataagcttg tttcgcgacg aagttcttcg ggatcgagca gctcacgccg ccgagcacga      60

gcgtcgtgcg ggcctcgcgc agatccttgc ccgcgtcgtc gcgcacgtgc gtgacgatgt     120

ccaccttcca gcccgccacc gcggtcacgt cgccgttgcg ccagccgtcc tgccggatca     180

gctggtcgaa ggcggtcacg cgggacacgg tcaggtcgga ggtggtctcg tccttgccga     240

tgttctcgtt cttgatgacc gacggcgggc cgagcttgag ccccttgacg tcgacgcccg     300

aagcgccgga cggcttgagc gcgccggttt cgtcccgcac ccagatcttg cccacgctcg     360

tcgacgacgt cgccttgctg ggcgacgagc agtcgacggc gctcttggcg ccttcaagca     420

ccagtacggt gttgtcggcg ggcttcgcgc ctccgcgccc gttgtcgagc agggcgtagt     480

tgctctccgc gaccgccgtc gggaccgtgg tctgctgcag cgcggcgagc acgttgtggt     540

cgcggctggc gataccgggc gggaacgggc tctgggcgcc gaagcggccc aggttgacag     600

cccatttgtc gccgaaggtg ttcttctcgc cgtcgtcacg cgggacgacg gtgcggtccg     660

gggagagttt cgactggcct ggcgtcagcg gcgagcgctg ggtctcggtg atcagcgatc     720

ccgggttccc gatgcgcacc gacgccacat tcgcgaacga cacggggccg gtcttctcat     780

cgacggcctg cgtcgtctgc gccgaggcga gccccggaac cgacgccaaa gcgacggccg     840

ccgtcgcggc ggccagcttc gtcacgaaac gagtcatgtc tccccactgc ctctccgggc     900

cctcagagcg cggtcgtcag cgtacgagaa gcgacgaaac gctccgcgac aaccttgcac     960

cgttggcgac cacatgcgaa gtggaatggt catttctttg ctaagtcacc cgaatggagc    1020

agtaacatcg ccgccaagtg gtcgcccggt cggcgaacag accaccgggg gcgggaacac    1080

taggatgggc aggactgtta ctggcaatga cttcggaaat catgatggac atggaggcgg    1140

cgatggctac ggtgaccccg gactctgccg cccccgggct ctcggaggac cccgggccgc    1200

attcgtcggc ccgtcccccc gccgaacccg cgacgtcggc ctcgcccgcc gtcctcgcgg    1260

acgccggcga cctgctcagg gcgctcgccg cgcccgtgcg catcgccatc gtcctgcagt    1320

tgcgtaacgc ggacaggtgc gtgcacgaac tggtggacac actcgatgtc gcgcagccgc    1380

tgatcagcca gcacctgcgg gtgctgaaga cggcgggtgt cgtacagggt gagcgacgcg    1440

gccgtgaggt ggtgtaccgg ctggtcgacg atcaccttgc gcatatcgtg gtggacgccg    1500

tagcccacgt tcaggagggg aagtgagcca tatgatt                             1537


