                         SEQUENCE LISTING

<110>  Spiber Technologies AB
 
<120>  A METHOD AND A CELL SCAFFOLD MATERIAL FOR CELL CULTURE

<130>  PC-21072195

<150>  EP 13184580
<151>  2013-09-16

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  149
<212>  PRT
<213>  Euprosthenops australis

<400>  1

Gly Ser Gly Asn Ser Gly Ile Gln Gly Gln Gly Gly Tyr Gly Gly Leu 
1               5                   10                  15      


Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln 
        35                  40                  45              


Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr 
65                  70                  75                  80  


Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln 
            100                 105                 110         


Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gln Gly Gln Gly 
    130                 135                 140                 


Gly Tyr Gly Gln Ser 
145                 


<210>  2
<211>  265
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  DOMAIN
<222>  (1)..(167)
<223>  REP fragment

<220>
<221>  DOMAIN
<222>  (168)..(265)
<223>  CT fragment

<400>  2

Gly Ser Gly Asn Ser Gly Ile Gln Gly Gln Gly Gly Tyr Gly Gly Leu 
1               5                   10                  15      


Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln 
        35                  40                  45              


Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr 
65                  70                  75                  80  


Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln 
            100                 105                 110         


Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gln Gly Gln Gly 
    130                 135                 140                 


Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala 
145                 150                 155                 160 


Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val 
                165                 170                 175     


Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val 
            180                 185                 190         


Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val 
        195                 200                 205             


Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala 
    210                 215                 220                 


Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser 
225                 230                 235                 240 


Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val 
                245                 250                 255     


Ala Asn Ala Met Ala Gln Val Met Gly 
            260                 265 


<210>  3
<211>  98
<212>  PRT
<213>  Euprosthenops australis

<400>  3

Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn 
            20                  25                  30          


Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala 
        35                  40                  45              


Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala 
    50                  55                  60                  


Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser 
65                  70                  75                  80  


Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val 
                85                  90                  95      


Met Gly 
        


<210>  4
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from known MaSp1 and MaSp2 proteins


<220>
<221>  MISC_FEATURE
<222>  (1)..(71)
<223>  Sequence length present in known species variants

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Glu

<400>  4

Ser Arg Leu Ser Ser Pro Gln Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Asn 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Val His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val Gly Gln Ser Val Ala Gln Ala 
                85                  90                  95      


Leu Gly Glu Phe 
            100 


<210>  5
<211>  1110
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  REPEAT
<222>  (7)..(19)

<220>
<221>  REPEAT
<222>  (20)..(42)

<220>
<221>  REPEAT
<222>  (43)..(56)

<220>
<221>  REPEAT
<222>  (57)..(70)

<220>
<221>  REPEAT
<222>  (71)..(83)

<220>
<221>  REPEAT
<222>  (84)..(106)

<220>
<221>  REPEAT
<222>  (107)..(120)

<220>
<221>  REPEAT
<222>  (121)..(134)

<220>
<221>  REPEAT
<222>  (135)..(147)

<220>
<221>  REPEAT
<222>  (148)..(170)

<220>
<221>  REPEAT
<222>  (171)..(183)

<220>
<221>  REPEAT
<222>  (184)..(197)

<220>
<221>  REPEAT
<222>  (198)..(211)

<220>
<221>  REPEAT
<222>  (212)..(234)

<220>
<221>  REPEAT
<222>  (235)..(248)

<220>
<221>  REPEAT
<222>  (249)..(265)

<220>
<221>  REPEAT
<222>  (266)..(279)

<220>
<221>  REPEAT
<222>  (280)..(293)

<220>
<221>  REPEAT
<222>  (294)..(306)

<220>
<221>  REPEAT
<222>  (307)..(329)

<220>
<221>  REPEAT
<222>  (330)..(342)

<220>
<221>  REPEAT
<222>  (343)..(356)

<220>
<221>  REPEAT
<222>  (357)..(370)

<220>
<221>  REPEAT
<222>  (371)..(393)

<220>
<221>  REPEAT
<222>  (394)..(406)

<220>
<221>  REPEAT
<222>  (407)..(420)

<220>
<221>  REPEAT
<222>  (421)..(434)

<220>
<221>  REPEAT
<222>  (435)..(457)

<220>
<221>  REPEAT
<222>  (458)..(470)

<220>
<221>  REPEAT
<222>  (471)..(488)

<220>
<221>  REPEAT
<222>  (489)..(502)

<220>
<221>  REPEAT
<222>  (503)..(516)

<220>
<221>  REPEAT
<222>  (517)..(529)

<220>
<221>  REPEAT
<222>  (530)..(552)

<220>
<221>  REPEAT
<222>  (553)..(566)

<220>
<221>  REPEAT
<222>  (567)..(580)

<220>
<221>  REPEAT
<222>  (581)..(594)

<220>
<221>  REPEAT
<222>  (595)..(617)

<220>
<221>  REPEAT
<222>  (618)..(630)

<220>
<221>  REPEAT
<222>  (631)..(647)

<220>
<221>  REPEAT
<222>  (648)..(661)

<220>
<221>  REPEAT
<222>  (662)..(675)

<220>
<221>  REPEAT
<222>  (676)..(688)

<220>
<221>  REPEAT
<222>  (689)..(711)

<220>
<221>  REPEAT
<222>  (712)..(725)

<220>
<221>  REPEAT
<222>  (726)..(739)

<220>
<221>  REPEAT
<222>  (740)..(752)

<220>
<221>  REPEAT
<222>  (753)..(775)

<220>
<221>  REPEAT
<222>  (776)..(789)

<220>
<221>  REPEAT
<222>  (790)..(803)

<220>
<221>  REPEAT
<222>  (804)..(816)

<220>
<221>  REPEAT
<222>  (817)..(839)

<220>
<221>  REPEAT
<222>  (840)..(853)

<220>
<221>  REPEAT
<222>  (854)..(867)

<220>
<221>  REPEAT
<222>  (868)..(880)

<220>
<221>  REPEAT
<222>  (881)..(903)

<220>
<221>  REPEAT
<222>  (904)..(917)

<220>
<221>  REPEAT
<222>  (918)..(931)

<220>
<221>  REPEAT
<222>  (932)..(945)

<220>
<221>  REPEAT
<222>  (946)..(968)

<220>
<221>  REPEAT
<222>  (969)..(981)

<220>
<221>  REPEAT
<222>  (982)..(998)

<220>
<221>  REPEAT
<222>  (999)..(1013)

<220>
<221>  REPEAT
<222>  (1014)..(1027)

<220>
<221>  REPEAT
<222>  (1028)..(1042)

<220>
<221>  REPEAT
<222>  (1043)..(1059)

<220>
<221>  REPEAT
<222>  (1060)..(1073)

<220>
<221>  REPEAT
<222>  (1074)..(1092)

<400>  5

Gln Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln 
            20                  25                  30          


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly 
    50                  55                  60                  


Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ser Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Gln Gly Gln 
                85                  90                  95      


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gln Gly Arg Tyr Gly 
        115                 120                 125             


Gln Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln 
145                 150                 155                 160 


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
                165                 170                 175     


Ser Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln 
            180                 185                 190         


Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln 
    210                 215                 220                 


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly 
                245                 250                 255     


Arg Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gln Gly Gly Tyr Gly Gln 
        275                 280                 285             


Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly 
305                 310                 315                 320 


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
            340                 345                 350         


Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Ala Ala 
        355                 360                 365             


Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly 
    370                 375                 380                 


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
                405                 410                 415     


Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly 
        435                 440                 445             


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Arg 
465                 470                 475                 480 


Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                485                 490                 495     


Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
            500                 505                 510         


Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        515                 520                 525             


Ser Gly Gln Gly Ser Gln Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly 
    530                 535                 540                 


Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
545                 550                 555                 560 


Ala Ala Ala Ala Ala Ser Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
                565                 570                 575     


Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly 
        595                 600                 605             


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
    610                 615                 620                 


Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr 
625                 630                 635                 640 


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                645                 650                 655     


Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser 
            660                 665                 670         


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser 
        675                 680                 685             


Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr 
    690                 695                 700                 


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
705                 710                 715                 720 


Ala Ala Ala Ala Ala Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ala 
                725                 730                 735     


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            740                 745                 750         


Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly Gly Tyr 
        755                 760                 765             


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    770                 775                 780                 


Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Val 
785                 790                 795                 800 


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                805                 810                 815     


Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly Gly Tyr 
            820                 825                 830         


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        835                 840                 845             


Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser 
    850                 855                 860                 


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser 
865                 870                 875                 880 


Gly Gln Gly Ser Gln Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr 
                885                 890                 895     


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            900                 905                 910         


Ala Ala Ala Ala Ser Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ala 
        915                 920                 925             


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    930                 935                 940                 


Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly 
945                 950                 955                 960 


Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                965                 970                 975     


Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly 
            980                 985                 990         


Gln Gly Ser Gly Gly Ser Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
        995                 1000                 1005             


Ala Ala  Ala Ala Ala Gly Arg  Gly Gln Gly Gly Tyr  Gly Gln Gly 
    1010                 1015                 1020             


Ser Gly  Gly Asn Ala Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1025                 1030                 1035             


Ala Ala  Ala Ala Gly Gln Gly  Gly Gln Gly Gly Tyr  Gly Arg Gln 
    1040                 1045                 1050             


Ser Gln  Gly Ala Gly Ser Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1055                 1060                 1065             


Ala Ala  Ala Ala Ala Gly Ser  Gly Gln Gly Gly Tyr  Gly Gly Gln 
    1070                 1075                 1080             


Gly Gln  Gly Gly Tyr Gly Gln  Ser Ser Ala Ser Ala  Ser Ala Ala 
    1085                 1090                 1095             


Ala Ser  Ala Ala Ser Thr Val  Ala Asn Ser Val Ser  
    1100                 1105                 1110 


<210>  6
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from internal repeats of Euprosthenops
       australis MaSp1


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Ser

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Tyr

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Gln

<400>  6

Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly Gly Tyr 
1               5                   10                  15      


Gly Gln Gly Ala Gly Ser Ser 
            20              


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from internal repeats of Euprosthenops
       australis MaSp1


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Arg

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Ser

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Gly

<400>  7

Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser 
1               5                   10                  15      


Ser 
    


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from internal repeats of Euprosthenops
       australis MaSp1


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Gln

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Arg

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Ser

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Val

<400>  8

Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Gly Asn 
1               5                   10                  


<210>  9
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered 4RepCT variant

<400>  9

Gly Pro Asn Ser Arg Gly Asp Ala Gly Ala Ala Ser Gly Gln Gly Gly 
1               5                   10                  15      


Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly 
        35                  40                  45              


Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln 
65                  70                  75                  80  


Gly Gly Tyr Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly 
            100                 105                 110         


Tyr Gly Arg Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly 
    130                 135                 140                 


Gly Gln Gly Gln Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala 
145                 150                 155                 160 


Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser 
                165                 170                 175     


Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val 
            180                 185                 190         


Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn 
        195                 200                 205             


Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu 
    210                 215                 220                 


Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile 
225                 230                 235                 240 


Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln 
                245                 250                 255     


Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val Met Gly 
            260                 265                 270 


<210>  10
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered 4RepCT variant

<400>  10

Gly Pro Asn Ser Ile Lys Val Ala Val Ala Gly Ala Arg Ser Gly Gln 
1               5                   10                  15      


Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly 
            20                  25                  30          


Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln 
        35                  40                  45              


Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg 
65                  70                  75                  80  


Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln 
            100                 105                 110         


Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly 
    130                 135                 140                 


Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala 
145                 150                 155                 160 


Ser Ala Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg 
                165                 170                 175     


Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser 
            180                 185                 190         


Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile 
        195                 200                 205             


Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly 
    210                 215                 220                 


Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val 
225                 230                 235                 240 


Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val 
                245                 250                 255     


Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val Met Gly 
            260                 265                 270         


<210>  11
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered 4RepCT variant

<400>  11

Gly Pro Asn Ser Tyr Ile Gly Ser Arg Gly Gln Gly Gly Tyr Gly Gly 
1               5                   10                  15      


Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gln 
        35                  40                  45              


Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr 
65                  70                  75                  80  


Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg 
            100                 105                 110         


Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly 
    130                 135                 140                 


Gln Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser 
145                 150                 155                 160 


Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser 
                165                 170                 175     


Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly 
            180                 185                 190         


Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser 
        195                 200                 205             


Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val 
    210                 215                 220                 


Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser 
225                 230                 235                 240 


Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn 
                245                 250                 255     


Val Val Ala Asn Ala Met Ala Gln Val Met Gly 
            260                 265         


<210>  12
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein


<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  VN fragment

<220>
<221>  DOMAIN
<222>  (21)..(179)
<223>  REP fragment

<220>
<221>  DOMAIN
<222>  (180)..(276)
<223>  CT fragment

<400>  12

Gly Pro Asn Ser Pro Gln Val Thr Arg Gly Asp Val Phe Thr Met Pro 
1               5                   10                  15      


Asn Ser Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly 
            20                  25                  30          


Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly 
    50                  55                  60                  


Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly 
                85                  90                  95      


Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala Gly 
        115                 120                 125             


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly 
    130                 135                 140                 


Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln 
145                 150                 155                 160 


Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr Val Ala 
                165                 170                 175     


Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser 
            180                 185                 190         


Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala 
        195                 200                 205             


Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala 
    210                 215                 220                 


Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val 
225                 230                 235                 240 


Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile 
                245                 250                 255     


Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met 
            260                 265                 270         


Ala Gln Val Met 
        275     


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-binding motif

<400>  13

Ile Lys Val Ala Val 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-binding motif

<400>  14

Tyr Ile Gly Ser Arg 
1               5   


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-binding motif

<400>  15

Pro Gln Val Thr Arg Gly Asp Val Phe Thr Met 
1               5                   10      


<210>  16
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VN oligo (sense)

<400>  16
aattctccgc aggtgacccg cggcgatgtg tttaccatgc cg                          42


<210>  17
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VN Oligo (antisense)

<400>  17
aattcggcat ggtaaacaca tcgccgcggg tcacctgcgg ag                          42


<210>  18
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein


<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  FN fragment

<220>
<221>  DOMAIN
<222>  (18)..(176)
<223>  REP fragment

<220>
<221>  DOMAIN
<222>  (177)..(273)
<223>  CT fragment

<400>  18

Gly Pro Asn Ser Thr Gly Arg Gly Asp Ser Pro Ala Pro Asn Ser Gly 
1               5                   10                  15      


Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala 
            20                  25                  30          


Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly 
        35                  40                  45              


Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly 
    50                  55                  60                  


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Asn Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly 
            100                 105                 110         


Gly Gln Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala Gly Ser Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln 
    130                 135                 140                 


Gly Gly Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Ser Ser Ala 
145                 150                 155                 160 


Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser Val 
                165                 170                 175     


Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val 
            180                 185                 190         


Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn 
        195                 200                 205             


Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala 
    210                 215                 220                 


Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala 
225                 230                 235                 240 


Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser 
                245                 250                 255     


Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val 
            260                 265                 270         


Met 
    


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell-binding motif

<400>  19

Thr Gly Arg Gly Asp Ser Pro Ala 
1               5               


