SEQUENCE LISTING


<110>  Compugen Ltd

<120>  VSTM5 POLYPEPTIDES AND USES THEREOF AS A DRUG FOR TREATMENT OF CANCER, INFECTIOUS DISEASES AND IMMUNE RELATED DISEASES


<130>  

<160>  156

<210>  1
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 1

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95      



<210>  2
<211>  119
<212>  PRT
<213>  Homo sapiens

<400> 2

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His 
        115                 



<210>  3
<211>  117
<212>  PRT
<213>  Homo sapiens

<400> 3

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp 
        115         



<210>  4
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400> 4

atgaggcctc tgcccagcgg gaggaggaag acccgaggca tctccctagg actcttcgcc     60

ctctgcctgg ccgcagcccg ctgtctgcag agtcagggtg tgtccctata cattcctcag    120

gccaccatca atgccactgt caaagaagac atcctgctct cagttgagta ctcctgtcat    180

ggagtgccca ccatcgaatg gacatattca tccaattggg gaacgcagaa gatcgtggag    240

tggaaaccag ggactcaggc caacatctct caaagccaca aggacagagt ctgcaccttt    300

gacaacggct ccatccagct cttcagcgtg ggagtgaggg attccggcta ctatgtcatc    360

accgtgacgg agcgcctggg gagcagccag tttggcacca tcgtgctgca cgtctctgag    420

atcctctatg aagacctgca ctttgtcgct gtcatccttg cttttctcgc tgctgtggcc    480

gcagtattaa tcagcctcat gtgggtttgt aataagtgtg catataaatt tcagaggaag    540

agaagacaca aactcaaaga aagcacaact gaggagattg agctggaaga tgttgagtgt    600

tagccaaggc tgggcctgac tgcattccta cctcaagagg aaaccattct ccaacaaaaa    660

gagcaagcac agctattata cccattgtgt gtggtcctgt tgcagcccgc tcctaacagg    720

acagtgggag attaacaaca ttgactgcat ggagttgagg actgtggatg ggacaaagct    780

agtattagga ctcgcgctaa gttcaaggag aagagtgatt gaggctttga accaggagct    840

tcgcttggct gcagcatcag ggccgtgctg acacataacc aatggcagtc ggaggaacca    900

ggctctgggc caggacagtt tccagtgctg tgaagaaacg aggtgagcag tatccaaggg    960

gctcaaggat aatctgctga tttctttctc gtctttcaca cagagaggcc accagcagga   1020

aagcagtggg agttgggtag ctgctggggc cagcatgtcc tcttccacac tacctgcctt   1080

tcagaactct gctcttccgc ttgtcccgaa gtcagggctg gcaatcttca taatcaaagg   1140

ggagttggaa aagaacaccc actaagaggc ctccatggca gatgtcaatt aaattgcccc   1200

cccccccaaa tctcatgaca gtttattcac atcagtagtg tgggaagtta caatgttttt   1260

tttaaaaaaa gcttctttcc ttggctttcc atttctttga aaaaagggtt tcttttgaat   1320

ttttaaagct ctgccatact gaacattcct gtggaaaggt ttaaaatgca gagcctgagg   1380

tttttgcttt tcagaaaaat aaaaatcata gagattagct agtgtaaatg ttaagctata   1440

aattatgttt caaactgtga aaaaaaaaag ttttaaagaa tgaatgaaat aaaacctgaa   1500

aataaagccc tggtcctttg                                               1520


<210>  5
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400> 5

atgaggcctc tgcccagcgg gaggaggaag acccgaggca tctccctagg actcttcgcc     60

ctctgcctgg ccgcagcccg ctgtctgcag agtcagggtg tgtccctata cattcctcag    120

gccaccatca atgccactgt caaagaagac atcctgctct cagttgagta ctcctgtcat    180

ggagtgccca ccatcgaatg gacatattca tccaattggg gaacgcagaa gatcgtggag    240

tggaaaccag ggactcaggc caacatctct caaagccaca aggacagagt ctgcaccttt    300

gacaacggct ccatccagct cttcagcgtg ggagtgaggg attccggcta ctatgtcatc    360

accgtgacgg agcgcctggg gagcagccag tttggcacca tcgtgctgca cgtctctgag    420

atcctctatg aagacctgca ctttgtcgct gtcatccttg cttttctcgc tgctgtggcc    480

gcagtattaa tcagcctcat gtgggtttgt aataagtgtg catataaatt tcagaggaag    540

agaagacaca aactcaaagg taaccccctg ggccttgtga taatccatga gtggttttga    600

ggccagaggt ggcatgtgtt atcttgttct cacgaagaaa gcactatgtg gcttgatttc    660

caactcattg acttgtcttt gctttacaga aagcacaact gaggagattg agctggaaga    720

tgttgagtgt tagccaaggc tgggcctgac tgcattccta cctcaagagg aaaccattct    780

ccaacaaaaa gagcaagcac agctattata cccattgtgt gtggtcctgt tgcagcccgc    840

tcctaacagg acagtgggag attaacaaca ttgactgcat ggagttgagg actgtggatg    900

ggacaaagct agtattagga ctcgcgctaa gttcaaggag aagagtgatt gaggctttga    960

accaggagct tcgcttggct gcagcatcag ggccgtgctg acacataacc aatggcagtc   1020

ggaggaacca ggctctgggc caggacagtt tccagtgctg tgaagaaacg aggtgagcag   1080

tatccaaggg gctcaaggat aatctgctga tttctttctc gtctttcaca cagagaggcc   1140

accagcagga aagcagtggg agttgggtag ctgctggggc cagcatgtcc tcttccacac   1200

tacctgcctt tcagaactct gctcttccgc ttgtcccgaa gtcagggctg gcaatcttca   1260

taatcaaagg ggagttggaa aagaacaccc actaagaggc ctccatggca gatgtcaatt   1320

aaattgcccc cccccccaaa tctcatgaca gtttattcac atcagtagtg tgggaagtta   1380

caatgttttt tttaaaaaaa gcttctttcc ttggctttcc atttctttga aaaaagggtt   1440

tcttttgaat ttttaaagct ctgccatact gaacattcct gtggaaaggt ttaaaatgca   1500

gagcctgagg tttttgcttt tcagaaaaat aaaaatcata gagattagct agtgtaaatg   1560

ttaagctata aattatgttt caaactgtga aaaaaaaaag ttttaaagaa tgaatgaaat   1620

aaaacctgaa aataaagccc tggtcctttg                                    1650


<210>  6
<211>  200
<212>  PRT
<213>  Homo sapiens

<400> 6

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala Val Ala 
145                 150                 155                 160 


Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala Tyr Lys 
                165                 170                 175     


Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser Thr Thr Glu Glu 
            180                 185                 190         


Ile Glu Leu Glu Asp Val Glu Cys 
        195                 200 



<210>  7
<211>  199
<212>  PRT
<213>  Homo sapiens

<400> 7

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala Val Ala 
145                 150                 155                 160 


Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala Tyr Lys 
                165                 170                 175     


Phe Gln Arg Lys Arg Arg His Lys Leu Lys Gly Asn Pro Leu Gly Leu 
            180                 185                 190         


Val Ile Ile His Glu Trp Phe 
        195                 



<210>  8
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc

<400> 8

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Ile Leu Leu Arg Val Ser Glu 
            100                 105                 110         


Ile Arg Tyr Glu Asp Leu His Glu Pro Arg Gly Pro Thr Ile Lys Pro 
        115                 120                 125             


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
145                 150                 155                 160 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                165                 170                 175     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            180                 185                 190         


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
        195                 200                 205             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
    210                 215                 220                 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
225                 230                 235                 240 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                245                 250                 255     


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
            260                 265                 270         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        275                 280                 285             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
305                 310                 315                 320 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                325                 330                 335     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345                 350         



<210>  9
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to EGFP

<400> 9

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala Val Ala 
145                 150                 155                 160 


Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala Tyr Lys 
                165                 170                 175     


Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser Thr Thr Glu Glu 
            180                 185                 190         


Ile Glu Leu Glu Asp Val Glu Cys Arg Ile Leu Gln Ser Thr Val Pro 
        195                 200                 205             


Arg Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser Lys Gly Glu Glu 
    210                 215                 220                 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
225                 230                 235                 240 


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
                245                 250                 255     


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
            260                 265                 270         


Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys 
        275                 280                 285             


Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
    290                 295                 300                 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
305                 310                 315                 320 


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
                325                 330                 335     


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
            340                 345                 350         


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val 
        355                 360                 365             


Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
    370                 375                 380                 


Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
385                 390                 395                 400 


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
                405                 410                 415     


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
            420                 425                 430         


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
        435                 440                 445             


Leu Gly Met Asp Glu Leu Tyr Lys 
    450                 455     



<210>  10
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to mouse IgG2a Fc

<400> 10

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly Glu Pro Arg Gly 
145                 150                 155                 160 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                165                 170                 175     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            180                 185                 190         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        195                 200                 205             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    210                 215                 220                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
225                 230                 235                 240 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                245                 250                 255     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            260                 265                 270         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        275                 280                 285             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    290                 295                 300                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
305                 310                 315                 320 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                325                 330                 335     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            340                 345                 350         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        355                 360                 365             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    370                 375                 380                 


Arg Thr Pro Gly Lys 
385                 



<210>  11
<211>  199
<212>  PRT
<213>  Homo sapiens

<400> 11

Met Arg Pro Leu Arg Cys Gly Glu Arg Thr Gln Gly Ile Pro Leu Gly 
1               5                   10                  15      


Leu Leu Ala Phe Trp Val Thr Ala Ala Arg Cys Leu Gln Ser Gln Gly 
            20                  25                  30          


Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn Ala Thr Val Gln Gln 
        35                  40                  45              


Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His Gly Val Pro Thr Ile 
    50                  55                  60                  


Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln Arg Ile Val Glu Trp 
65                  70                  75                  80  


Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser His Arg Asp Arg Val 
                85                  90                  95      


Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Asn Val Ser Val Lys 
            100                 105                 110         


Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu His Pro Gly Ser Ser 
        115                 120                 125             


Gln Ser Gly Thr Ile Leu Leu Arg Val Ser Glu Ile Arg Tyr Glu Asp 
    130                 135                 140                 


Leu His Phe Val Ala Val Phe Phe Ala Leu Leu Ala Ala Val Ala Val 
145                 150                 155                 160 


Val Leu Ile Ser Leu Met Trp Val Cys Asn Gln Cys Ala Tyr Lys Phe 
                165                 170                 175     


Gln Arg Lys Arg Arg Tyr Lys Leu Lys Glu Ser Thr Thr Glu Glu Ile 
            180                 185                 190         


Glu Met Lys Glu Val Glu Cys 
        195                 



<210>  12
<211>  18
<212>  PRT
<213>  Homo sapiens

<400> 12

Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val 
1               5                   10                  15      


Glu Trp 
        



<210>  13
<211>  19
<212>  PRT
<213>  Homo sapiens

<400> 13

Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val 
1               5                   10                  15      


Glu Trp Lys 
            



<210>  14
<211>  19
<212>  PRT
<213>  Homo sapiens

<400> 14

Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
1               5                   10                  15      


Val Glu Trp 
            



<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400> 15

Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
1               5                   10                  15      


Val Glu Trp Lys 
            20  



<210>  16
<211>  28
<212>  PRT
<213>  Homo sapiens

<400> 16

Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
1               5                   10                  15      


Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr 
            20                  25              



<210>  17
<211>  23
<212>  PRT
<213>  Homo sapiens

<400> 17

Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
1               5                   10                  15      


Gly Thr Ile Val Leu His Val 
            20              



<210>  18
<211>  27
<212>  PRT
<213>  Homo sapiens

<400> 18

Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
1               5                   10                  15      


Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            20                  25          



<210>  19
<211>  12
<212>  PRT
<213>  Homo sapiens

<400> 19

Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
1               5                   10          



<210>  20
<211>  17
<212>  PRT
<213>  Homo sapiens

<400> 20

Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly 
1               5                   10                  15      


Val 
    



<210>  21
<211>  12
<212>  PRT
<213>  Homo sapiens

<400> 21

Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
1               5                   10          



<210>  22
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 22

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
            100                 105         



<210>  23
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 23

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
            100                 105     



<210>  24
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 24

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val 
            100                 105 



<210>  25
<211>  108
<212>  PRT
<213>  Homo sapiens

<400> 25

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
            100                 105             



<210>  26
<211>  109
<212>  PRT
<213>  Homo sapiens

<400> 26

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
            100                 105                 



<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400> 27

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
            100                 105                 110 



<210>  28
<211>  111
<212>  PRT
<213>  Homo sapiens

<400> 28

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105                 110     



<210>  29
<211>  112
<212>  PRT
<213>  Homo sapiens

<400> 29

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         



<210>  30
<211>  113
<212>  PRT
<213>  Homo sapiens

<400> 30

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile 
    



<210>  31
<211>  114
<212>  PRT
<213>  Homo sapiens

<400> 31

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu 
        



<210>  32
<211>  115
<212>  PRT
<213>  Homo sapiens

<400> 32

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr 
        115 



<210>  33
<211>  116
<212>  PRT
<213>  Homo sapiens

<400> 33

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu 
        115     



<210>  34
<211>  118
<212>  PRT
<213>  Homo sapiens

<400> 34

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu 
        115             



<210>  35
<211>  120
<212>  PRT
<213>  Homo sapiens

<400> 35

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Phe 
        115                 120 



<210>  36
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 36

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
            100                 105         



<210>  37
<211>  108
<212>  PRT
<213>  Homo sapiens

<400> 37

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
            100                 105             



<210>  38
<211>  109
<212>  PRT
<213>  Homo sapiens

<400> 38

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
            100                 105                 



<210>  39
<211>  110
<212>  PRT
<213>  Homo sapiens

<400> 39

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105                 110 



<210>  40
<211>  111
<212>  PRT
<213>  Homo sapiens

<400> 40

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110     



<210>  41
<211>  112
<212>  PRT
<213>  Homo sapiens

<400> 41

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         



<210>  42
<211>  113
<212>  PRT
<213>  Homo sapiens

<400> 42

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu 
    



<210>  43
<211>  114
<212>  PRT
<213>  Homo sapiens

<400> 43

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr 
        



<210>  44
<211>  115
<212>  PRT
<213>  Homo sapiens

<400> 44

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu 
        115 



<210>  45
<211>  116
<212>  PRT
<213>  Homo sapiens

<400> 45

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp 
        115     



<210>  46
<211>  117
<212>  PRT
<213>  Homo sapiens

<400> 46

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp Leu 
        115         



<210>  47
<211>  118
<212>  PRT
<213>  Homo sapiens

<400> 47

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp Leu His 
        115             



<210>  48
<211>  119
<212>  PRT
<213>  Homo sapiens

<400> 48

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110         


Leu Tyr Glu Asp Leu His Phe 
        115                 



<210>  49
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 49

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
            100                 105     



<210>  50
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 50

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
            100                 105         



<210>  51
<211>  108
<212>  PRT
<213>  Homo sapiens

<400> 51

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
            100                 105             



<210>  52
<211>  109
<212>  PRT
<213>  Homo sapiens

<400> 52

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105                 



<210>  53
<211>  110
<212>  PRT
<213>  Homo sapiens

<400> 53

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110 



<210>  54
<211>  111
<212>  PRT
<213>  Homo sapiens

<400> 54

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105                 110     



<210>  55
<211>  112
<212>  PRT
<213>  Homo sapiens

<400> 55

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         



<210>  56
<211>  113
<212>  PRT
<213>  Homo sapiens

<400> 56

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr 
    



<210>  57
<211>  114
<212>  PRT
<213>  Homo sapiens

<400> 57

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu 
        



<210>  58
<211>  115
<212>  PRT
<213>  Homo sapiens

<400> 58

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp 
        115 



<210>  59
<211>  116
<212>  PRT
<213>  Homo sapiens

<400> 59

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp Leu 
        115     



<210>  60
<211>  117
<212>  PRT
<213>  Homo sapiens

<400> 60

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp Leu His 
        115         



<210>  61
<211>  118
<212>  PRT
<213>  Homo sapiens

<400> 61

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu 
            100                 105                 110         


Tyr Glu Asp Leu His Phe 
        115             



<210>  62
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 62

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      



<210>  63
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 63

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu 
    



<210>  64
<211>  98
<212>  PRT
<213>  Homo sapiens

<400> 64

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu His 
        



<210>  65
<211>  99
<212>  PRT
<213>  Homo sapiens

<400> 65

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu His Val 
            



<210>  66
<211>  100
<212>  PRT
<213>  Homo sapiens

<400> 66

Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val 
1               5                   10                  15      


Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser 
            20                  25                  30          


Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala 
        35                  40                  45              


Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly 
    50                  55                  60                  


Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95      


Leu His Val Ser 
            100 



<210>  67
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 67

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  95  



<210>  68
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 68

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      



<210>  69
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 69

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      


His 
    



<210>  70
<211>  98
<212>  PRT
<213>  Homo sapiens

<400> 70

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      


His Val 
        



<210>  71
<211>  99
<212>  PRT
<213>  Homo sapiens

<400> 71

Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu 
1               5                   10                  15      


Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn 
            20                  25                  30          


Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn 
        35                  40                  45              


Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser 
    50                  55                  60                  


Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile 
65                  70                  75                  80  


Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95      


His Val Ser 
            



<210>  72
<211>  94
<212>  PRT
<213>  Homo sapiens

<400> 72

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90                  



<210>  73
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 73

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  95  



<210>  74
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 74

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95      


Val 
    



<210>  75
<211>  98
<212>  PRT
<213>  Homo sapiens

<400> 75

Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr 
1               5                   10                  15      


Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp 
            20                  25                  30          


Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile 
        35                  40                  45              


Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile 
    50                  55                  60                  


Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr 
65                  70                  75                  80  


Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95      


Val Ser 
        



<210>  76
<211>  93
<212>  PRT
<213>  Homo sapiens

<400> 76

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90              



<210>  77
<211>  94
<212>  PRT
<213>  Homo sapiens

<400> 77

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90                  



<210>  78
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 78

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  95  



<210>  79
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 79

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
                85                  90                  95      



<210>  80
<211>  97
<212>  PRT
<213>  Homo sapiens

<400> 80

Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser 
1               5                   10                  15      


Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly 
            20                  25                  30          


Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser 
        35                  40                  45              


Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln 
    50                  55                  60                  


Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val 
65                  70                  75                  80  


Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
                85                  90                  95      


Ser 
    



<210>  81
<211>  92
<212>  PRT
<213>  Homo sapiens

<400> 81

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val 
                85                  90          



<210>  82
<211>  93
<212>  PRT
<213>  Homo sapiens

<400> 82

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu 
                85                  90              



<210>  83
<211>  94
<212>  PRT
<213>  Homo sapiens

<400> 83

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His 
                85                  90                  



<210>  84
<211>  95
<212>  PRT
<213>  Homo sapiens

<400> 84

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val 
                85                  90                  95  



<210>  85
<211>  96
<212>  PRT
<213>  Homo sapiens

<400> 85

Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys 
1               5                   10                  15      


His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr 
            20                  25                  30          


Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln 
        35                  40                  45              


Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu 
    50                  55                  60                  


Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr 
65                  70                  75                  80  


Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser 
                85                  90                  95      



<210>  86
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 86

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His 
            100             



<210>  87
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 87

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val 
            100                 



<210>  88
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 88

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val Ser 
            100                 105 



<210>  89
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 89

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105     



<210>  90
<211>  107
<212>  PRT
<213>  Homo sapiens

<400> 90

Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp 
1               5                   10                  15      


Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu 
            20                  25                  30          


Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys 
        35                  40                  45              


Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys 
    50                  55                  60                  


Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp 
65                  70                  75                  80  


Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln 
                85                  90                  95      


Phe Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105         



<210>  91
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 91

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His 
            100         



<210>  92
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 92

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val 
            100             



<210>  93
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 93

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val Ser 
            100                 



<210>  94
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 94

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105 



<210>  95
<211>  106
<212>  PRT
<213>  Homo sapiens

<400> 95

Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile 
1               5                   10                  15      


Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp 
            20                  25                  30          


Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro 
        35                  40                  45              


Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr 
    50                  55                  60                  


Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser 
65                  70                  75                  80  


Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe 
                85                  90                  95      


Gly Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105     



<210>  96
<211>  101
<212>  PRT
<213>  Homo sapiens

<400> 96

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His 
            100     



<210>  97
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 97

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val 
            100         



<210>  98
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 98

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val Ser 
            100             



<210>  99
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 99

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val Ser Glu 
            100                 



<210>  100
<211>  105
<212>  PRT
<213>  Homo sapiens

<400> 100

Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu 
1               5                   10                  15      


Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr 
            20                  25                  30          


Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly 
        35                  40                  45              


Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe 
    50                  55                  60                  


Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly 
65                  70                  75                  80  


Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly 
                85                  90                  95      


Thr Ile Val Leu His Val Ser Glu Ile 
            100                 105 



<210>  101
<211>  100
<212>  PRT
<213>  Homo sapiens

<400> 101

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His 
            100 



<210>  102
<211>  101
<212>  PRT
<213>  Homo sapiens

<400> 102

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val 
            100     



<210>  103
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 103

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val Ser 
            100         



<210>  104
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 104

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val Ser Glu 
            100             



<210>  105
<211>  104
<212>  PRT
<213>  Homo sapiens

<400> 105

Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu 
1               5                   10                  15      


Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr 
            20                  25                  30          


Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr 
        35                  40                  45              


Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp 
    50                  55                  60                  


Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr 
                85                  90                  95      


Ile Val Leu His Val Ser Glu Ile 
            100                 



<210>  106
<211>  99
<212>  PRT
<213>  Homo sapiens

<400> 106

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His 
            



<210>  107
<211>  100
<212>  PRT
<213>  Homo sapiens

<400> 107

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val 
            100 



<210>  108
<211>  101
<212>  PRT
<213>  Homo sapiens

<400> 108

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val Ser 
            100     



<210>  109
<211>  102
<212>  PRT
<213>  Homo sapiens

<400> 109

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val Ser Glu 
            100         



<210>  110
<211>  103
<212>  PRT
<213>  Homo sapiens

<400> 110

Pro Gln Ala Thr Ile Asn Ala Thr Val Lys Glu Asp Ile Leu Leu Ser 
1               5                   10                  15      


Val Glu Tyr Ser Cys His Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser 
            20                  25                  30          


Ser Asn Trp Gly Thr Gln Lys Ile Val Glu Trp Lys Pro Gly Thr Gln 
        35                  40                  45              


Ala Asn Ile Ser Gln Ser His Lys Asp Arg Val Cys Thr Phe Asp Asn 
    50                  55                  60                  


Gly Ser Ile Gln Leu Phe Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr 
65                  70                  75                  80  


Val Ile Thr Val Thr Glu Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
                85                  90                  95      


Val Leu His Val Ser Glu Ile 
            100             



<210>  111
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S

<400> 111

Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu 
1               5                   10                  15      


Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln 
            20                  25                  30          


Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys 
        35                  40                  45              


Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr 
    50                  55                  60                  


Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu 
65                  70                  75                  80  


Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg 
                85                  90                  95      


Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val 
            100                 105                 110         


Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser 
        115                 120                 125             


Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu 
    130                 135                 140                 


Asp Leu His Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 



<210>  112
<211>  233
<212>  PRT
<213>  Mus Musculus

<400> 112

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             



<210>  113
<211>  232
<212>  PRT
<213>  Homo sapiens

<400> 113

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         



<210>  114
<211>  232
<212>  PRT
<213>  Homo sapiens

<400> 114

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         



<210>  115
<211>  217
<212>  PRT
<213>  Homo sapiens

<400> 115

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         



<210>  116
<211>  217
<212>  PRT
<213>  Mus Musculus

<400> 116

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            100                 105                 110         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        115                 120                 125             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    130                 135                 140                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
145                 150                 155                 160 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                165                 170                 175     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            180                 185                 190         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        195                 200                 205             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    210                 215         



<210>  117
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 117

Gly Ser 
1       



<210>  118
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 118

Gly Ser Gly Ser 
1               



<210>  119
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 119

Ala Ser 
1       



<210>  120
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 120

Gly Gly Gly Ser 
1               



<210>  121
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 121

Gly Gly Gly Gly Ser 
1               5   



<210>  122
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 122

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  



<210>  123
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 123

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  



<210>  124
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 124

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  



<210>  125
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 125

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Ala 
1               5                   10          



<210>  126
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 126

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys 
1               5                   10                  15      


Ala 
    



<210>  127
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 127

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys 
1               5                   10                  15      


Gly Ala Ala Ala Lys Ala 
            20          



<210>  128
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 128

Ala Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys 
1               5                   10                  15      


Gly Ala Ala Ala Lys Gly Ala Ala Ala Lys Ala 
            20                  25          



<210>  129
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide linker

<400> 129

Ala Gly Ala Ala Ala Lys Ala 
1               5           



<210>  130
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc

<400>  130

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Glu Pro Lys Ser Ser Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     


<210>  131
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to mouse IgG2a Fc

<400>  131

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly 
        115                 120                 125             


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
    130                 135                 140                 


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
145                 150                 155                 160 


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
            180                 185                 190         


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
        195                 200                 205             


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
    210                 215                 220                 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
225                 230                 235                 240 


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
                245                 250                 255     


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
            260                 265                 270         


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
        275                 280                 285             


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
    290                 295                 300                 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
305                 310                 315                 320 


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
                325                 330                 335     


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
            340                 345                 350         


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        355                 360     



<210>  132
<211>  172
<212>  PRT
<213>  Homo Sapiens

<400>  132

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu 
        115                 120                 125             


Ala Ala Val Ala Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys 
    130                 135                 140                 


Cys Ala Tyr Lys Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser 
145                 150                 155                 160 


Thr Thr Glu Glu Ile Glu Leu Glu Asp Val Glu Cys 
                165                 170         



<210>  133
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to EGFP

<400>  133

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu 
        115                 120                 125             


Ala Ala Val Ala Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys 
    130                 135                 140                 


Cys Ala Tyr Lys Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser 
145                 150                 155                 160 


Thr Thr Glu Glu Ile Glu Leu Glu Asp Val Glu Cys Arg Ile Leu Gln 
                165                 170                 175     


Ser Thr Val Pro Arg Ala Arg Asp Pro Pro Val Ala Thr Met Val Ser 
            180                 185                 190         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        195                 200                 205             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
    210                 215                 220                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
225                 230                 235                 240 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
                245                 250                 255     


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
            260                 265                 270         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        275                 280                 285             


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    290                 295                 300                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
305                 310                 315                 320 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
                325                 330                 335     


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            340                 345                 350         


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
        355                 360                 365             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    370                 375                 380                 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
385                 390                 395                 400 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                405                 410                 415     


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            420                 425             




<210>  134
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S

<400>  134

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Glu Pro Lys Ser Ser Asp Lys 
            100                 105                 110         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        115                 120                 125             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            180                 185                 190         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        275                 280                 285             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    290                 295                 300                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     


Lys 
    



<210>  135
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S (G4S)x2 linker

<400>  135

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
        115                 120                 125             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    130                 135                 140                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
145                 150                 155                 160 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                165                 170                 175     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            180                 185                 190         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        195                 200                 205             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    210                 215                 220                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
225                 230                 235                 240 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                245                 250                 255     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            260                 265                 270         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        275                 280                 285             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    290                 295                 300                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
305                 310                 315                 320 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                325                 330                 335     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345         



<210>  136
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc

<400>  136

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Glu Pro Arg Gly Pro Thr Ile 
            100                 105                 110         


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
        115                 120                 125             


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    130                 135                 140                 


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
145                 150                 155                 160 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                165                 170                 175     


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            180                 185                 190         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        195                 200                 205             


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
225                 230                 235                 240 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
                245                 250                 255     


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
            260                 265                 270         


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
    290                 295                 300                 


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
305                 310                 315                 320 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
                325                 330                 335     


Gly Lys 
        



<210>  137
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc (G4S)x2 linker

<400>  137

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
        115                 120                 125             


Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val 
145                 150                 155                 160 


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
                165                 170                 175     


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
            180                 185                 190         


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
        195                 200                 205             


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
    210                 215                 220                 


Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
225                 230                 235                 240 


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
                245                 250                 255     


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
            260                 265                 270         


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
        275                 280                 285             


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
    290                 295                 300                 


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
305                 310                 315                 320 


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
                325                 330                 335     


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345             



<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  138

Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Gly 
1               5                   10      



<210>  139
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  139

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala His Glu Leu Ile 
1               5                   10                  15      


Cys Ala Leu Leu Ile Asn Lys Glu Arg 
            20                  25  



<210>  140
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  140

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala 
            20          



<210>  141
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  141

Gly Gly Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Gly Gly 
1               5                   10                  



<210>  142
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  142

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            



<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  143

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      



<210>  144
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  144

Gly Gly Gly Gly Ser Gly 
1               5       



<210>  145
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  145

Gly Ser Gly Gly 
1               



<210>  146
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide linker

<400>  146

Gly Ser Gly Gly Ser 
1               5   


<210>  147
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc N297A


<400>  147

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ser Ala Ile Asn 
1               5                   10                  15      


Ala Thr Val Gln Gln Asp Ile Leu Leu Ser Val Asp Tyr Ile Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Lys Tyr Thr Pro Asn Trp Gly Val Gln 
        35                  40                  45              


Arg Ile Val Glu Trp Lys Pro Gly Thr Pro Ala Asn Val Ser Gln Ser 
    50                  55                  60                  


His Arg Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Asn Val Ser Val Lys Asp Ser Gly Tyr Tyr Ile Val Thr Val Thr Glu 
                85                  90                  95      


His Pro Gly Ser Ser Gln Ser Gly Thr Ile Leu Leu Arg Val Ser Glu 
            100                 105                 110         


Ile Arg Tyr Glu Asp Leu His Glu Pro Arg Gly Pro Thr Ile Lys Pro 
        115                 120                 125             


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
145                 150                 155                 160 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                165                 170                 175     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            180                 185                 190         


Gln Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val 
        195                 200                 205             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
    210                 215                 220                 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
225                 230                 235                 240 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                245                 250                 255     


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
            260                 265                 270         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        275                 280                 285             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
305                 310                 315                 320 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                325                 330                 335     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345                 350         



<210>  148
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: mouse VSTM5-ECD fused to mouse IgG2a Fc N297A

<400>  148

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             



<210>  149
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: human VSTM5-ECD fused to human IgG1 Fc C220S N297A

<400>  149

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu 
            100                 105                 110         


Ile Leu Tyr Glu Asp Leu His Glu Pro Lys Ser Ser Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     



<210>  150
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG1 Fc C220S N297A


<400>  150

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         



<210>  151
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  151

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr 
            100                 105 



<210>  152
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  152

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr 
            100                 



<210>  153
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  153

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr 
            100             



<210>  154
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  154

Leu Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn 
1               5                   10                  15      


Ala Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His 
            20                  25                  30          


Gly Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln 
        35                  40                  45              


Lys Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser 
    50                  55                  60                  


His Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe 
65                  70                  75                  80  


Ser Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu 
                85                  90                  95      


Arg Leu Gly Ser Ser Gln Phe Gly Thr Ile 
            100                 105     



<210>  155
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  155

Gln Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala 
1               5                   10                  15      


Thr Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly 
            20                  25                  30          


Val Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys 
        35                  40                  45              


Ile Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His 
    50                  55                  60                  


Lys Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser 
65                  70                  75                  80  


Val Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg 
                85                  90                  95      


Leu Gly Ser Ser Gln Phe Gly Thr Ile 
            100                 105 



<210>  156
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  156

Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr 
1               5                   10                  15      


Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val 
            20                  25                  30          


Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile 
        35                  40                  45              


Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys 
    50                  55                  60                  


Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val 
65                  70                  75                  80  


Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu 
                85                  90                  95      


Gly Ser Ser Gln Phe Gly Thr Ile 
            100                 







