                         SEQUENCE LISTING



<110>  Plexicure Ltd.

       Gruper, Yaron

       Aloya, Revital

       Kigel, Boaz

 

<120>  ISOLATED PROTEINS CAPABLE OF BINDING PLEXIN-A4 AND METHODS OF 

       PRODUCING AND USING SAME



<130>  60129



<150>  US 61/878,125

<151>  2013-09-16



<160>  103   



<170>  PatentIn version 3.5



<210>  1

<211>  108

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 158 VkL



<400>  1



Asp Ile Val Ile Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 

1               5                   10                  15      





Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 

            20                  25                  30          





Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 

        35                  40                  45              





Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 

    50                  55                  60                  





Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 

65                  70                  75                  80  





Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 

                85                  90                  95      





Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 

            100                 105             





<210>  2

<211>  119

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 158 VH



<400>  2



Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 

1               5                   10                  15      





Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 

            20                  25                  30          





Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 

        35                  40                  45              





Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 

    50                  55                  60                  





Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 

65                  70                  75                  80  





Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Asn Ala Pro Ser Met Val Thr Thr Gly Phe Ala Tyr Trp Gly Gln Gly 

            100                 105                 110         





Thr Leu Val Thr Val Ser Ser 

        115                 





<210>  3

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 20 VkL



<400>  3



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 

            100                 105                 110         





Arg 

    





<210>  4

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 20 VH



<400>  4



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  5

<211>  108

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27 VkL



<400>  5



Asp Ile Leu Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 

1               5                   10                  15      





Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 

            20                  25                  30          





Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 

        35                  40                  45              





Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 

    50                  55                  60                  





Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 

65                  70                  75                  80  





Glu Asp Leu Ala Asp Tyr Ser Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 

                85                  90                  95      





Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 

            100                 105             





<210>  6

<211>  119

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27 VH



<400>  6



Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 

1               5                   10                  15      





Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 

            20                  25                  30          





Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 

        35                  40                  45              





Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 

    50                  55                  60                  





Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 

65                  70                  75                  80  





Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      





Asn Ala Pro Ser Met Val Thr Thr Gly Phe Ala Tyr Trp Gly Gln Gly 

            100                 105                 110         





Thr Leu Val Thr Val Ser Ser 

        115                 





<210>  7

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 25 VkL



<400>  7



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 

            100                 105                 110         





Arg 

    





<210>  8

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 25 VH



<400>  8



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Asn Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  9

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 21 VkL



<400>  9



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 

            100                 105                 110         





Arg 

    





<210>  10

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 21 VH



<400>  10



Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Gly Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu His Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val His Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  11

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 30 VkL



<400>  11



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 

            100                 105                 110         





Arg 

    





<210>  12

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 30 VH



<400>  12



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  13

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 146 VkL



<400>  13



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 

            100                 105                 110         





Arg 

    





<210>  14

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 146 VH



<400>  14



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  15

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 151 VkL



<400>  15



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 

            100                 105                 110         





Arg 

    





<210>  16

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 151 VH



<400>  16



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  17

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 139 VkL



<400>  17



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 

            100                 105                 110         





Arg 

    





<210>  18

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 139 VH



<400>  18



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  19

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 60 VkL



<400>  19



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 

            100                 105                 110         





Arg 

    





<210>  20

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 60 VH



<400>  20



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  21

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 69 VkL



<400>  21



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 

            100                 105                 110         





Arg 

    





<210>  22

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 69 VH



<400>  22



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  23

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 75 VkL



<400>  23



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 

            100                 105                 110         





Arg 

    





<210>  24

<211>  117

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 75 VH



<400>  24



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser Ser 

        115         





<210>  25

<211>  113

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 86 VkL



<400>  25



Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 

1               5                   10                  15      





Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 

            20                  25                  30          





Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 

        35                  40                  45              





Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 

    50                  55                  60                  





Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 

65                  70                  75                  80  





Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 

                85                  90                  95      





Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 

            100                 105                 110         





Arg 

    





<210>  26

<211>  116

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 86 VH



<400>  26



Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      





Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 

            20                  25                  30          





Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 

        35                  40                  45              





Ala Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

    50                  55                  60                  





Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 

65                  70                  75                  80  





Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 

                85                  90                  95      





Ala Ser Leu Asp Val Tyr Phe Val Asp Tyr Trp Gly Gln Gly Thr Thr 

            100                 105                 110         





Leu Thr Val Ser 

        115     





<210>  27

<211>  1194

<212>  PRT

<213>  Homo sapiens



<400>  27



Ser Phe Val Thr Phe Arg Gly Glu Pro Ala Glu Gly Phe Asn His Leu 

1               5                   10                  15      





Val Val Asp Glu Arg Thr Gly His Ile Tyr Leu Gly Ala Val Asn Arg 

            20                  25                  30          





Ile Tyr Lys Leu Ser Ser Asp Leu Lys Val Leu Val Thr His Glu Thr 

        35                  40                  45              





Gly Pro Asp Glu Asp Asn Pro Lys Cys Tyr Pro Pro Arg Ile Val Gln 

    50                  55                  60                  





Thr Cys Asn Glu Pro Leu Thr Thr Thr Asn Asn Val Asn Lys Met Leu 

65                  70                  75                  80  





Leu Ile Asp Tyr Lys Glu Asn Arg Leu Ile Ala Cys Gly Ser Leu Tyr 

                85                  90                  95      





Gln Gly Ile Cys Lys Leu Leu Arg Leu Glu Asp Leu Phe Lys Leu Gly 

            100                 105                 110         





Glu Pro Tyr His Lys Lys Glu His Tyr Leu Ser Gly Val Asn Glu Ser 

        115                 120                 125             





Gly Ser Val Phe Gly Val Ile Val Ser Tyr Ser Asn Leu Asp Asp Lys 

    130                 135                 140                 





Leu Phe Ile Ala Thr Ala Val Asp Gly Lys Pro Glu Tyr Phe Pro Thr 

145                 150                 155                 160 





Ile Ser Ser Arg Lys Leu Thr Lys Asn Ser Glu Ala Asp Gly Met Phe 

                165                 170                 175     





Ala Tyr Val Phe His Asp Glu Phe Val Ala Ser Met Ile Lys Ile Pro 

            180                 185                 190         





Ser Asp Thr Phe Thr Ile Ile Pro Asp Phe Asp Ile Tyr Tyr Val Tyr 

        195                 200                 205             





Gly Phe Ser Ser Gly Asn Phe Val Tyr Phe Leu Thr Leu Gln Pro Glu 

    210                 215                 220                 





Met Val Ser Pro Pro Gly Ser Thr Thr Lys Glu Gln Val Tyr Thr Ser 

225                 230                 235                 240 





Lys Leu Val Arg Leu Cys Lys Glu Asp Thr Ala Phe Asn Ser Tyr Val 

                245                 250                 255     





Glu Val Pro Ile Gly Cys Glu Arg Ser Gly Val Glu Tyr Arg Leu Leu 

            260                 265                 270         





Gln Ala Ala Tyr Leu Ser Lys Ala Gly Ala Val Leu Gly Arg Thr Leu 

        275                 280                 285             





Gly Val His Pro Asp Asp Asp Leu Leu Phe Thr Val Phe Ser Lys Gly 

    290                 295                 300                 





Gln Lys Arg Lys Met Lys Ser Leu Asp Glu Ser Ala Leu Cys Ile Phe 

305                 310                 315                 320 





Ile Leu Lys Gln Ile Asn Asp Arg Ile Lys Glu Arg Leu Gln Ser Cys 

                325                 330                 335     





Tyr Arg Gly Glu Gly Thr Leu Asp Leu Ala Trp Leu Lys Val Lys Asp 

            340                 345                 350         





Ile Pro Cys Ser Ser Ala Leu Leu Thr Ile Asp Asp Asn Phe Cys Gly 

        355                 360                 365             





Leu Asp Met Asn Ala Pro Leu Gly Val Ser Asp Met Val Arg Gly Ile 

    370                 375                 380                 





Pro Val Phe Thr Glu Asp Arg Asp Arg Met Thr Ser Val Ile Ala Tyr 

385                 390                 395                 400 





Val Tyr Lys Asn His Ser Leu Ala Phe Val Gly Thr Lys Ser Gly Lys 

                405                 410                 415     





Leu Lys Lys Ile Arg Val Asp Gly Pro Arg Gly Asn Ala Leu Gln Tyr 

            420                 425                 430         





Glu Thr Val Gln Val Val Asp Pro Gly Pro Val Leu Arg Asp Met Ala 

        435                 440                 445             





Phe Ser Lys Asp His Glu Gln Leu Tyr Ile Met Ser Glu Arg Gln Leu 

    450                 455                 460                 





Thr Arg Val Pro Val Glu Ser Cys Gly Gln Tyr Gln Ser Cys Gly Glu 

465                 470                 475                 480 





Cys Leu Gly Ser Gly Asp Pro His Cys Gly Trp Cys Val Leu His Asn 

                485                 490                 495     





Thr Cys Thr Arg Lys Glu Arg Cys Glu Arg Ser Lys Glu Pro Arg Arg 

            500                 505                 510         





Phe Ala Ser Glu Met Lys Gln Cys Val Arg Leu Thr Val His Pro Asn 

        515                 520                 525             





Asn Ile Ser Val Ser Gln Tyr Asn Val Leu Leu Val Leu Glu Thr Tyr 

    530                 535                 540                 





Asn Val Pro Glu Leu Ser Ala Gly Val Asn Cys Thr Phe Glu Asp Leu 

545                 550                 555                 560 





Ser Glu Met Asp Gly Leu Val Val Gly Asn Gln Ile Gln Cys Tyr Ser 

                565                 570                 575     





Pro Ala Ala Lys Glu Val Pro Arg Ile Ile Thr Glu Asn Gly Asp His 

            580                 585                 590         





His Val Val Gln Leu Gln Leu Lys Ser Lys Glu Thr Gly Met Thr Phe 

        595                 600                 605             





Ala Ser Thr Ser Phe Val Phe Tyr Asn Cys Ser Val His Asn Ser Cys 

    610                 615                 620                 





Leu Ser Cys Val Glu Ser Pro Tyr Arg Cys His Trp Cys Lys Tyr Arg 

625                 630                 635                 640 





His Val Cys Thr His Asp Pro Lys Thr Cys Ser Phe Gln Glu Gly Arg 

                645                 650                 655     





Val Lys Leu Pro Glu Asp Cys Pro Gln Leu Leu Arg Val Asp Lys Ile 

            660                 665                 670         





Leu Val Pro Val Glu Val Ile Lys Pro Ile Thr Leu Lys Ala Lys Asn 

        675                 680                 685             





Leu Pro Gln Pro Gln Ser Gly Gln Arg Gly Tyr Glu Cys Ile Leu Asn 

    690                 695                 700                 





Ile Gln Gly Ser Glu Gln Arg Val Pro Ala Leu Arg Phe Asn Ser Ser 

705                 710                 715                 720 





Ser Val Gln Cys Gln Asn Thr Ser Tyr Ser Tyr Glu Gly Met Glu Ile 

                725                 730                 735     





Asn Asn Leu Pro Val Glu Leu Thr Val Val Trp Asn Gly His Phe Asn 

            740                 745                 750         





Ile Asp Asn Pro Ala Gln Asn Lys Val His Leu Tyr Lys Cys Gly Ala 

        755                 760                 765             





Met Arg Glu Ser Cys Gly Leu Cys Leu Lys Ala Asp Pro Asp Phe Ala 

    770                 775                 780                 





Cys Gly Trp Cys Gln Gly Pro Gly Gln Cys Thr Leu Arg Gln His Cys 

785                 790                 795                 800 





Pro Ala Gln Glu Ser Gln Trp Leu Glu Leu Ser Gly Ala Lys Ser Lys 

                805                 810                 815     





Cys Thr Asn Pro Arg Ile Thr Glu Ile Ile Pro Val Thr Gly Pro Arg 

            820                 825                 830         





Glu Gly Gly Thr Lys Val Thr Ile Arg Gly Glu Asn Leu Gly Leu Glu 

        835                 840                 845             





Phe Arg Asp Ile Ala Ser His Val Lys Val Ala Gly Val Glu Cys Ser 

    850                 855                 860                 





Pro Leu Val Asp Gly Tyr Ile Pro Ala Glu Gln Ile Val Cys Glu Met 

865                 870                 875                 880 





Gly Glu Ala Lys Pro Ser Gln His Ala Gly Phe Val Glu Ile Cys Val 

                885                 890                 895     





Ala Val Cys Arg Pro Glu Phe Met Ala Arg Ser Ser Gln Leu Tyr Tyr 

            900                 905                 910         





Phe Met Thr Leu Thr Leu Ser Asp Leu Lys Pro Ser Arg Gly Pro Met 

        915                 920                 925             





Ser Gly Gly Thr Gln Val Thr Ile Thr Gly Thr Asn Leu Asn Ala Gly 

    930                 935                 940                 





Ser Asn Val Val Val Met Phe Gly Lys Gln Pro Cys Leu Phe His Arg 

945                 950                 955                 960 





Arg Ser Pro Ser Tyr Ile Val Cys Asn Thr Thr Ser Ser Asp Glu Val 

                965                 970                 975     





Leu Glu Met Lys Val Ser Val Gln Val Asp Arg Ala Lys Ile His Gln 

            980                 985                 990         





Asp Leu Val Phe Gln Tyr Val Glu  Asp Pro Thr Ile Val  Arg Ile Glu 

        995                 1000                 1005             





Pro Glu  Trp Ser Ile Val Ser  Gly Asn Thr Pro Ile  Ala Val Trp 

    1010                 1015                 1020             





Gly Thr  His Leu Asp Leu Ile  Gln Asn Pro Gln Ile  Arg Ala Lys 

    1025                 1030                 1035             





His Gly  Gly Lys Glu His Ile  Asn Ile Cys Glu Val  Leu Asn Ala 

    1040                 1045                 1050             





Thr Glu  Met Thr Cys Gln Ala  Pro Ala Leu Ala Leu  Gly Pro Asp 

    1055                 1060                 1065             





His Gln  Ser Asp Leu Thr Glu  Arg Pro Glu Glu Phe  Gly Phe Ile 

    1070                 1075                 1080             





Leu Asp  Asn Val Gln Ser Leu  Leu Ile Leu Asn Lys  Thr Asn Phe 

    1085                 1090                 1095             





Thr Tyr  Tyr Pro Asn Pro Val  Phe Glu Ala Phe Gly  Pro Ser Gly 

    1100                 1105                 1110             





Ile Leu  Glu Leu Lys Pro Gly  Thr Pro Ile Ile Leu  Lys Gly Lys 

    1115                 1120                 1125             





Asn Leu  Ile Pro Pro Val Ala  Gly Gly Asn Val Lys  Leu Asn Tyr 

    1130                 1135                 1140             





Thr Val  Leu Val Gly Glu Lys  Pro Cys Thr Val Thr  Val Ser Asp 

    1145                 1150                 1155             





Val Gln  Leu Leu Cys Glu Ser  Pro Asn Leu Ile Gly  Arg His Lys 

    1160                 1165                 1170             





Val Met  Ala Arg Val Gly Gly  Met Glu Tyr Ser Pro  Gly Met Val 

    1175                 1180                 1185             





Tyr Ile  Ala Pro Asp Ser 

    1190                 





<210>  28

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Plexin A4 antibody  CDR consensus sequence





<220>

<221>  misc_feature

<222>  (1)..(1)

<223>  Serine or Glutamine



<220>

<221>  misc_feature

<222>  (3)..(3)

<223>  Hydroxylated amino acid



<220>

<221>  misc_feature

<222>  (4)..(4)

<223>  Serine or Glutamine



<220>

<221>  misc_feature

<222>  (5)..(5)

<223>  Serine or histidine



<220>

<221>  misc_feature

<222>  (6)..(6)

<223>  Tyrosine or valine



<220>

<221>  misc_feature

<222>  (8)..(8)

<223>  Hydrophobic amino acid



<400>  28



Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 

1               5                   





<210>  29

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 158 VLk CDR3



<400>  29



Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 

1               5                   





<210>  30

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clones 75, 151and 139, VLk CDR3



<400>  30



Ser Gln Ser Thr His Val Pro Leu Thr 

1               5                   





<210>  31

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clones 86, 69, 60 and 146, VLk CDR3



<400>  31



Ser Gln Ser Thr His Val Pro Trp Thr 

1               5                   





<210>  32

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR1



<400>  32



Asp Tyr Tyr Met His 

1               5   





<210>  33

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR2



<400>  33



Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln 

1               5                   10                  15      





<210>  34

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR3



<400>  34



Met Val Thr Thr Gly Phe Ala Tyr 

1               5               





<210>  35

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR1



<400>  35



Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 

1               5                   10      





<210>  36

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR2



<400>  36



Trp Ala Ser Thr Arg His Thr 

1               5           





<210>  37

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR1



<400>  37



Asp Tyr Ala Met Ser 

1               5   





<210>  38

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR2



<400>  38



Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 

1               5                   10                  15      





<210>  39

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR3



<400>  39



Leu Asp Val Tyr Phe Val Asp Tyr 

1               5               





<210>  40

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR1



<400>  40



Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 

1               5                   10                  15      





<210>  41

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR2



<400>  41



Lys Val Ser Asn Arg Phe Ser 

1               5           





<210>  42

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR1



<400>  42



Asp Tyr Ala Met Ser 

1               5   





<210>  43

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR2



<400>  43



Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 

1               5                   10                  15      





<210>  44

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR3



<400>  44



Leu Asp Val Tyr Phe Val Asp Tyr 

1               5               





<210>  45

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR1



<400>  45



Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 

1               5                   10                  15      





<210>  46

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR2



<400>  46



Lys Val Ser Asn Arg Phe Ser 

1               5           





<210>  47

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR1



<400>  47



Asp Tyr Ala Met Ser 

1               5   





<210>  48

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR2



<400>  48



Thr Ile Ser Gly Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 

1               5                   10                  15      





<210>  49

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR3



<400>  49



Leu Asp Val His Phe Val Asp Tyr 

1               5               





<210>  50

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR1



<400>  50



Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 

1               5                   10                  15      





<210>  51

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR2



<400>  51



Lys Val Ser Asn Arg Phe Ser 

1               5           





<210>  52

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR1



<400>  52



Asp Tyr Ala Met Ser 

1               5   





<210>  53

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR2



<400>  53



Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 

1               5                   10                  15      





<210>  54

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VH CDR3



<400>  54



Asp Val Asn Phe Val Asp Tyr 

1               5           





<210>  55

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR1



<400>  55



Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 

1               5                   10                  15      





<210>  56

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  VkL CDR2



<400>  56



Lys Val Ser Asn Arg Phe Ser 

1               5           





<210>  57

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Plexin A4 antibody  CDR consensus sequence





<220>

<221>  misc_feature

<222>  (3)..(3)

<223>  Any amino acid



<220>

<221>  misc_feature

<222>  (5)..(5)

<223>  Histidine or Serine



<400>  57



Asp Tyr Xaa Met Xaa 

1               5   





<210>  58

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 158 VH CDR1



<400>  58



Asp Tyr Tyr Met His 

1               5   





<210>  59

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clones 75, 86, 69, 60, 139, 151, 146, 30, 20, 25 and 21 VH CDR1



<400>  59



Asp Tyr Ala Met Ser 

1               5   





<210>  60

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  heavy chain CDR1



<400>  60



Asp Tyr Ala Met Ser 

1               5   





<210>  61

<211>  15

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Heavy chain CDR2





<220>

<221>  misc_feature

<222>  (1)..(4)

<223>  Can be G or S



<400>  61



Thr Ile Ser Xaa Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 

1               5                   10                  15  





<210>  62

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Heavy chain CDR3





<220>

<221>  misc_feature

<222>  (4)..(4)

<223>  Histidine, tyrosine or asparagine



<400>  62



Leu Asp Val Xaa Phe Val Asp Tyr 

1               5               





<210>  63

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Light chain CDR1



<400>  63



Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 

1               5                   10                  15      





<210>  64

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Light chain CDR2



<400>  64



Lys Val Ser Asn Arg Phe Ser 

1               5           





<210>  65

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Light chain CDR3





<220>

<221>  misc_feature

<222>  (8)..(8)

<223>  Leucine or Tryptophane



<400>  65



Ser Gln Ser Thr His Val Pro Xaa Thr 

1               5                   





<210>  66

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 21 VkL CDR3



<400>  66



Ser Gln Ser Thr His Val Pro Trp Thr 

1               5                   





<210>  67

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 86 VkL CDR3



<400>  67



Ser Gln Ser Thr His Val Pro Trp Thr 

1               5                   





<210>  68

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 25 VkL CDR3



<400>  68



Ser Gln Ser Thr His Val Pro Trp Thr 

1               5                   





<210>  69

<211>  10

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clones 75, 151 and 138 VkL CDR3



<400>  69



Cys Ser Gln Ser Thr His Val Pro Leu Thr 

1               5                   10  





<210>  70

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 158 VkL CDR3



<400>  70



Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 

1               5                   





<210>  71

<211>  11

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27 VkL CDR1



<400>  71



Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 

1               5                   10      





<210>  72

<211>  7

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27 VkL CDR2



<400>  72



Trp Ala Ser Thr Arg His Thr 

1               5           





<210>  73

<211>  9

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27 VkL CDR3



<400>  73



Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr 

1               5                   





<210>  74

<211>  5

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27  VH CDR1



<400>  74



Asp Tyr Tyr Met His 

1               5   





<210>  75

<211>  16

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27  VH CDR2



<400>  75



Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln 

1               5                   10                  15      





<210>  76

<211>  8

<212>  PRT

<213>  Artificial sequence



<220>

<223>  Clone 27  VH CDR3



<400>  76



Met Val Thr Thr Gly Phe Ala Tyr 

1               5               





<210>  77

<211>  1894

<212>  PRT

<213>  Homo sapiens





<220>

<221>  misc_feature

<222>  (1)..(38)

<223>  Signal peptide



<220>

<221>  misc_feature

<222>  (39)..(1232)

<223>  Extra cellular domain



<220>

<221>  misc_feature

<222>  (1233)..(1894)

<223>  Cytoplasmic  domain



<400>  77



Met Lys Ala Met Pro Trp Asn Trp Thr Cys Leu Leu Ser His Leu Leu 

1               5                   10                  15      





Met Val Gly Met Gly Ser Ser Thr Leu Leu Thr Arg Gln Pro Ala Pro 

            20                  25                  30          





Leu Ser Gln Lys Gln Arg Ser Phe Val Thr Phe Arg Gly Glu Pro Ala 

        35                  40                  45              





Glu Gly Phe Asn His Leu Val Val Asp Glu Arg Thr Gly His Ile Tyr 

    50                  55                  60                  





Leu Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Ser Asp Leu Lys Val 

65                  70                  75                  80  





Leu Val Thr His Glu Thr Gly Pro Asp Glu Asp Asn Pro Lys Cys Tyr 

                85                  90                  95      





Pro Pro Arg Ile Val Gln Thr Cys Asn Glu Pro Leu Thr Thr Thr Asn 

            100                 105                 110         





Asn Val Asn Lys Met Leu Leu Ile Asp Tyr Lys Glu Asn Arg Leu Ile 

        115                 120                 125             





Ala Cys Gly Ser Leu Tyr Gln Gly Ile Cys Lys Leu Leu Arg Leu Glu 

    130                 135                 140                 





Asp Leu Phe Lys Leu Gly Glu Pro Tyr His Lys Lys Glu His Tyr Leu 

145                 150                 155                 160 





Ser Gly Val Asn Glu Ser Gly Ser Val Phe Gly Val Ile Val Ser Tyr 

                165                 170                 175     





Ser Asn Leu Asp Asp Lys Leu Phe Ile Ala Thr Ala Val Asp Gly Lys 

            180                 185                 190         





Pro Glu Tyr Phe Pro Thr Ile Ser Ser Arg Lys Leu Thr Lys Asn Ser 

        195                 200                 205             





Glu Ala Asp Gly Met Phe Ala Tyr Val Phe His Asp Glu Phe Val Ala 

    210                 215                 220                 





Ser Met Ile Lys Ile Pro Ser Asp Thr Phe Thr Ile Ile Pro Asp Phe 

225                 230                 235                 240 





Asp Ile Tyr Tyr Val Tyr Gly Phe Ser Ser Gly Asn Phe Val Tyr Phe 

                245                 250                 255     





Leu Thr Leu Gln Pro Glu Met Val Ser Pro Pro Gly Ser Thr Thr Lys 

            260                 265                 270         





Glu Gln Val Tyr Thr Ser Lys Leu Val Arg Leu Cys Lys Glu Asp Thr 

        275                 280                 285             





Ala Phe Asn Ser Tyr Val Glu Val Pro Ile Gly Cys Glu Arg Ser Gly 

    290                 295                 300                 





Val Glu Tyr Arg Leu Leu Gln Ala Ala Tyr Leu Ser Lys Ala Gly Ala 

305                 310                 315                 320 





Val Leu Gly Arg Thr Leu Gly Val His Pro Asp Asp Asp Leu Leu Phe 

                325                 330                 335     





Thr Val Phe Ser Lys Gly Gln Lys Arg Lys Met Lys Ser Leu Asp Glu 

            340                 345                 350         





Ser Ala Leu Cys Ile Phe Ile Leu Lys Gln Ile Asn Asp Arg Ile Lys 

        355                 360                 365             





Glu Arg Leu Gln Ser Cys Tyr Arg Gly Glu Gly Thr Leu Asp Leu Ala 

    370                 375                 380                 





Trp Leu Lys Val Lys Asp Ile Pro Cys Ser Ser Ala Leu Leu Thr Ile 

385                 390                 395                 400 





Asp Asp Asn Phe Cys Gly Leu Asp Met Asn Ala Pro Leu Gly Val Ser 

                405                 410                 415     





Asp Met Val Arg Gly Ile Pro Val Phe Thr Glu Asp Arg Asp Arg Met 

            420                 425                 430         





Thr Ser Val Ile Ala Tyr Val Tyr Lys Asn His Ser Leu Ala Phe Val 

        435                 440                 445             





Gly Thr Lys Ser Gly Lys Leu Lys Lys Ile Arg Val Asp Gly Pro Arg 

    450                 455                 460                 





Gly Asn Ala Leu Gln Tyr Glu Thr Val Gln Val Val Asp Pro Gly Pro 

465                 470                 475                 480 





Val Leu Arg Asp Met Ala Phe Ser Lys Asp His Glu Gln Leu Tyr Ile 

                485                 490                 495     





Met Ser Glu Arg Gln Leu Thr Arg Val Pro Val Glu Ser Cys Gly Gln 

            500                 505                 510         





Tyr Gln Ser Cys Gly Glu Cys Leu Gly Ser Gly Asp Pro His Cys Gly 

        515                 520                 525             





Trp Cys Val Leu His Asn Thr Cys Thr Arg Lys Glu Arg Cys Glu Arg 

    530                 535                 540                 





Ser Lys Glu Pro Arg Arg Phe Ala Ser Glu Met Lys Gln Cys Val Arg 

545                 550                 555                 560 





Leu Thr Val His Pro Asn Asn Ile Ser Val Ser Gln Tyr Asn Val Leu 

                565                 570                 575     





Leu Val Leu Glu Thr Tyr Asn Val Pro Glu Leu Ser Ala Gly Val Asn 

            580                 585                 590         





Cys Thr Phe Glu Asp Leu Ser Glu Met Asp Gly Leu Val Val Gly Asn 

        595                 600                 605             





Gln Ile Gln Cys Tyr Ser Pro Ala Ala Lys Glu Val Pro Arg Ile Ile 

    610                 615                 620                 





Thr Glu Asn Gly Asp His His Val Val Gln Leu Gln Leu Lys Ser Lys 

625                 630                 635                 640 





Glu Thr Gly Met Thr Phe Ala Ser Thr Ser Phe Val Phe Tyr Asn Cys 

                645                 650                 655     





Ser Val His Asn Ser Cys Leu Ser Cys Val Glu Ser Pro Tyr Arg Cys 

            660                 665                 670         





His Trp Cys Lys Tyr Arg His Val Cys Thr His Asp Pro Lys Thr Cys 

        675                 680                 685             





Ser Phe Gln Glu Gly Arg Val Lys Leu Pro Glu Asp Cys Pro Gln Leu 

    690                 695                 700                 





Leu Arg Val Asp Lys Ile Leu Val Pro Val Glu Val Ile Lys Pro Ile 

705                 710                 715                 720 





Thr Leu Lys Ala Lys Asn Leu Pro Gln Pro Gln Ser Gly Gln Arg Gly 

                725                 730                 735     





Tyr Glu Cys Ile Leu Asn Ile Gln Gly Ser Glu Gln Arg Val Pro Ala 

            740                 745                 750         





Leu Arg Phe Asn Ser Ser Ser Val Gln Cys Gln Asn Thr Ser Tyr Ser 

        755                 760                 765             





Tyr Glu Gly Met Glu Ile Asn Asn Leu Pro Val Glu Leu Thr Val Val 

    770                 775                 780                 





Trp Asn Gly His Phe Asn Ile Asp Asn Pro Ala Gln Asn Lys Val His 

785                 790                 795                 800 





Leu Tyr Lys Cys Gly Ala Met Arg Glu Ser Cys Gly Leu Cys Leu Lys 

                805                 810                 815     





Ala Asp Pro Asp Phe Ala Cys Gly Trp Cys Gln Gly Pro Gly Gln Cys 

            820                 825                 830         





Thr Leu Arg Gln His Cys Pro Ala Gln Glu Ser Gln Trp Leu Glu Leu 

        835                 840                 845             





Ser Gly Ala Lys Ser Lys Cys Thr Asn Pro Arg Ile Thr Glu Ile Ile 

    850                 855                 860                 





Pro Val Thr Gly Pro Arg Glu Gly Gly Thr Lys Val Thr Ile Arg Gly 

865                 870                 875                 880 





Glu Asn Leu Gly Leu Glu Phe Arg Asp Ile Ala Ser His Val Lys Val 

                885                 890                 895     





Ala Gly Val Glu Cys Ser Pro Leu Val Asp Gly Tyr Ile Pro Ala Glu 

            900                 905                 910         





Gln Ile Val Cys Glu Met Gly Glu Ala Lys Pro Ser Gln His Ala Gly 

        915                 920                 925             





Phe Val Glu Ile Cys Val Ala Val Cys Arg Pro Glu Phe Met Ala Arg 

    930                 935                 940                 





Ser Ser Gln Leu Tyr Tyr Phe Met Thr Leu Thr Leu Ser Asp Leu Lys 

945                 950                 955                 960 





Pro Ser Arg Gly Pro Met Ser Gly Gly Thr Gln Val Thr Ile Thr Gly 

                965                 970                 975     





Thr Asn Leu Asn Ala Gly Ser Asn Val Val Val Met Phe Gly Lys Gln 

            980                 985                 990         





Pro Cys Leu Phe His Arg Arg Ser  Pro Ser Tyr Ile Val  Cys Asn Thr 

        995                 1000                 1005             





Thr Ser  Ser Asp Glu Val Leu  Glu Met Lys Val Ser  Val Gln Val 

    1010                 1015                 1020             





Asp Arg  Ala Lys Ile His Gln  Asp Leu Val Phe Gln  Tyr Val Glu 

    1025                 1030                 1035             





Asp Pro  Thr Ile Val Arg Ile  Glu Pro Glu Trp Ser  Ile Val Ser 

    1040                 1045                 1050             





Gly Asn  Thr Pro Ile Ala Val  Trp Gly Thr His Leu  Asp Leu Ile 

    1055                 1060                 1065             





Gln Asn  Pro Gln Ile Arg Ala  Lys His Gly Gly Lys  Glu His Ile 

    1070                 1075                 1080             





Asn Ile  Cys Glu Val Leu Asn  Ala Thr Glu Met Thr  Cys Gln Ala 

    1085                 1090                 1095             





Pro Ala  Leu Ala Leu Gly Pro  Asp His Gln Ser Asp  Leu Thr Glu 

    1100                 1105                 1110             





Arg Pro  Glu Glu Phe Gly Phe  Ile Leu Asp Asn Val  Gln Ser Leu 

    1115                 1120                 1125             





Leu Ile  Leu Asn Lys Thr Asn  Phe Thr Tyr Tyr Pro  Asn Pro Val 

    1130                 1135                 1140             





Phe Glu  Ala Phe Gly Pro Ser  Gly Ile Leu Glu Leu  Lys Pro Gly 

    1145                 1150                 1155             





Thr Pro  Ile Ile Leu Lys Gly  Lys Asn Leu Ile Pro  Pro Val Ala 

    1160                 1165                 1170             





Gly Gly  Asn Val Lys Leu Asn  Tyr Thr Val Leu Val  Gly Glu Lys 

    1175                 1180                 1185             





Pro Cys  Thr Val Thr Val Ser  Asp Val Gln Leu Leu  Cys Glu Ser 

    1190                 1195                 1200             





Pro Asn  Leu Ile Gly Arg His  Lys Val Met Ala Arg  Val Gly Gly 

    1205                 1210                 1215             





Met Glu  Tyr Ser Pro Gly Met  Val Tyr Ile Ala Pro  Asp Ser Pro 

    1220                 1225                 1230             





Leu Ser  Leu Pro Ala Ile Val  Ser Ile Ala Val Ala  Gly Gly Leu 

    1235                 1240                 1245             





Leu Ile  Ile Phe Ile Val Ala  Val Leu Ile Ala Tyr  Lys Arg Lys 

    1250                 1255                 1260             





Ser Arg  Glu Ser Asp Leu Thr  Leu Lys Arg Leu Gln  Met Gln Met 

    1265                 1270                 1275             





Asp Asn  Leu Glu Ser Arg Val  Ala Leu Glu Cys Lys  Glu Ala Phe 

    1280                 1285                 1290             





Ala Glu  Leu Gln Thr Asp Ile  His Glu Leu Thr Ser  Asp Leu Asp 

    1295                 1300                 1305             





Gly Ala  Gly Ile Pro Phe Leu  Asp Tyr Arg Thr Tyr  Thr Met Arg 

    1310                 1315                 1320             





Val Leu  Phe Pro Gly Ile Glu  Asp His Pro Val Leu  Arg Asp Leu 

    1325                 1330                 1335             





Glu Val  Pro Gly Tyr Arg Gln  Glu Arg Val Glu Lys  Gly Leu Lys 

    1340                 1345                 1350             





Leu Phe  Ala Gln Leu Ile Asn  Asn Lys Val Phe Leu  Leu Ser Phe 

    1355                 1360                 1365             





Ile Arg  Thr Leu Glu Ser Gln  Arg Ser Phe Ser Met  Arg Asp Arg 

    1370                 1375                 1380             





Gly Asn  Val Ala Ser Leu Ile  Met Thr Val Leu Gln  Ser Lys Leu 

    1385                 1390                 1395             





Glu Tyr  Ala Thr Asp Val Leu  Lys Gln Leu Leu Ala  Asp Leu Ile 

    1400                 1405                 1410             





Asp Lys  Asn Leu Glu Ser Lys  Asn His Pro Lys Leu  Leu Leu Arg 

    1415                 1420                 1425             





Arg Thr  Glu Ser Val Ala Glu  Lys Met Leu Thr Asn  Trp Phe Thr 

    1430                 1435                 1440             





Phe Leu  Leu Tyr Lys Phe Leu  Lys Glu Cys Ala Gly  Glu Pro Leu 

    1445                 1450                 1455             





Phe Ser  Leu Phe Cys Ala Ile  Lys Gln Gln Met Glu  Lys Gly Pro 

    1460                 1465                 1470             





Ile Asp  Ala Ile Thr Gly Glu  Ala Arg Tyr Ser Leu  Ser Glu Asp 

    1475                 1480                 1485             





Lys Leu  Ile Arg Gln Gln Ile  Asp Tyr Lys Thr Leu  Val Leu Ser 

    1490                 1495                 1500             





Cys Val  Ser Pro Asp Asn Ala  Asn Ser Pro Glu Val  Pro Val Lys 

    1505                 1510                 1515             





Ile Leu  Asn Cys Asp Thr Ile  Thr Gln Val Lys Glu  Lys Ile Leu 

    1520                 1525                 1530             





Asp Ala  Ile Phe Lys Asn Val  Pro Cys Ser His Arg  Pro Lys Ala 

    1535                 1540                 1545             





Ala Asp  Met Asp Leu Glu Trp  Arg Gln Gly Ser Gly  Ala Arg Met 

    1550                 1555                 1560             





Ile Leu  Gln Asp Glu Asp Ile  Thr Thr Lys Ile Glu  Asn Asp Trp 

    1565                 1570                 1575             





Lys Arg  Leu Asn Thr Leu Ala  His Tyr Gln Val Pro  Asp Gly Ser 

    1580                 1585                 1590             





Val Val  Ala Leu Val Ser Lys  Gln Val Thr Ala Tyr  Asn Ala Val 

    1595                 1600                 1605             





Asn Asn  Ser Thr Val Ser Arg  Thr Ser Ala Ser Lys  Tyr Glu Asn 

    1610                 1615                 1620             





Met Ile  Arg Tyr Thr Gly Ser  Pro Asp Ser Leu Arg  Ser Arg Thr 

    1625                 1630                 1635             





Pro Met  Ile Thr Pro Asp Leu  Glu Ser Gly Val Lys  Met Trp His 

    1640                 1645                 1650             





Leu Val  Lys Asn His Glu His  Gly Asp Gln Lys Glu  Gly Asp Arg 

    1655                 1660                 1665             





Gly Ser  Lys Met Val Ser Glu  Ile Tyr Leu Thr Arg  Leu Leu Ala 

    1670                 1675                 1680             





Thr Lys  Gly Thr Leu Gln Lys  Phe Val Asp Asp Leu  Phe Glu Thr 

    1685                 1690                 1695             





Ile Phe  Ser Thr Ala His Arg  Gly Ser Ala Leu Pro  Leu Ala Ile 

    1700                 1705                 1710             





Lys Tyr  Met Phe Asp Phe Leu  Asp Glu Gln Ala Asp  Lys His Gly 

    1715                 1720                 1725             





Ile His  Asp Pro His Val Arg  His Thr Trp Lys Ser  Asn Cys Leu 

    1730                 1735                 1740             





Pro Leu  Arg Phe Trp Val Asn  Met Ile Lys Asn Pro  Gln Phe Val 

    1745                 1750                 1755             





Phe Asp  Ile His Lys Asn Ser  Ile Thr Asp Ala Cys  Leu Ser Val 

    1760                 1765                 1770             





Val Ala  Gln Thr Phe Met Asp  Ser Cys Ser Thr Ser  Glu His Arg 

    1775                 1780                 1785             





Leu Gly  Lys Asp Ser Pro Ser  Asn Lys Leu Leu Tyr  Ala Lys Asp 

    1790                 1795                 1800             





Ile Pro  Ser Tyr Lys Asn Trp  Val Glu Arg Tyr Tyr  Ser Asp Ile 

    1805                 1810                 1815             





Gly Lys  Met Pro Ala Ile Ser  Asp Gln Asp Met Asn  Ala Tyr Leu 

    1820                 1825                 1830             





Ala Glu  Gln Ser Arg Met His  Met Asn Glu Phe Asn  Thr Met Ser 

    1835                 1840                 1845             





Ala Leu  Ser Glu Ile Phe Ser  Tyr Val Gly Lys Tyr  Ser Glu Glu 

    1850                 1855                 1860             





Ile Leu  Gly Pro Leu Asp His  Asp Asp Gln Cys Gly  Lys Gln Lys 

    1865                 1870                 1875             





Leu Ala  Tyr Lys Leu Glu Gln  Val Ile Thr Leu Met  Ser Leu Asp 

    1880                 1885                 1890             





Ser 

    





<210>  78

<211>  324

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 158 light chain coding sequence



<400>  78

gatattgtga taacgcagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60



atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120



gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180



cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240



gaagacttgg cagattattt ctgtcagcaa tatagcagct atcccctcac gttcggtgct      300



gggaccaagc tggagctgaa acgg                                             324





<210>  79

<211>  357

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 158 Heavy chain coding sequence



<400>  79

gaggtccagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60



tcctgcacag cttctggctt caacattaaa gactactata tgcactgggt gaagcagagg      120



cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180



gccccgaagt tccagggcaa ggccactatg actgcagaca catcctccaa cacagcctac      240



ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtaa tgcccctagt      300



atggtaacta cggggtttgc ttactggggc caagggactc tggtcactgt ctcttca         357





<210>  80

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 20 light chain coding sequence



<400>  80

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac caagctggag ctgaaacgg                             339





<210>  81

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 20 Heavy chain coding sequence



<400>  81

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  82

<211>  324

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 27 light chain coding sequence



<400>  82

gatattctga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60



atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120



gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180



cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240



gaagacttgg cagattattc ctgtcagcaa tatagcagct atccgtacac gttcggaggg      300



gggacaaagc tggaaataaa acgg                                             324





<210>  83

<211>  357

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 27 Heavy chain coding sequence



<400>  83

gaggtccagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60



tcctgcacag cttctggctt caacattaaa gactactata tgcactgggt gaagcagagg      120



cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180



gccccgaagt tccagggcaa ggccactatg actgcagaca catcctccaa cacagcctac      240



ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtaa tgcccctagt      300



atggtaacta cggggtttgc ttactggggc caagggactc tggtcactgt ctcttca         357





<210>  84

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 25 light chain coding sequence



<400>  84

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac aaagctggaa ataaaacgg                             339





<210>  85

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 25 Heavy chain coding sequence



<400>  85

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt ccgccagact      120



ccggggaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gttaacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  86

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 21 light chain coding sequence



<400>  86

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac caagctggag ctgaaacgg                             339





<210>  87

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 21 Heavy chain coding sequence



<400>  87

gaggtgaagc tggtggaatc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtggtg gtggtgggta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcacatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gttcacttcg tggactactg gggccagggc accacgctca cagtctcctc a               351





<210>  88

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 30 light chain coding sequence



<400>  88

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac aaagttggaa ataaaacgg                             339





<210>  89

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 30 Heavy chain coding sequence



<400>  89

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  90

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 146 light chain coding sequence



<400>  90

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac caagctggag ctgaaacgg                             339





<210>  91

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 146 Heavy chain coding sequence



<400>  91

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  92

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 151 light chain coding sequence



<400>  92

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagacttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct      300



ctcacgttcg gtgctgggac caagctggaa ataaaacgg                             339





<210>  93

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 151 Heavy chain coding sequence



<400>  93

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  94

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 139 light chain coding sequence



<400>  94

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct      300



ctcacgttcg gtgctgggac caagctggag ctgaaacgg                             339





<210>  95

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 139 Heavy chain coding sequence



<400>  95

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  96

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 60 light chain coding sequence



<400>  96

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac caagctggaa ataaaacgg                             339





<210>  97

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 60 Heavy chain coding sequence



<400>  97

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  98

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 69 light chain coding sequence



<400>  98

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac caagctggaa ataaaacgg                             339





<210>  99

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 69 Heavy chain coding sequence



<400>  99

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  100

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 75 light chain coding sequence



<400>  100

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagacttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct      300



ctcacgttcg gtgctgggac caagctggag ctgaaacgg                             339





<210>  101

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 75 Heavy chain coding sequence



<400>  101

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





<210>  102

<211>  339

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 86 light chain coding sequence



<400>  102

gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60



atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120



tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180



tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240



agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300



tggacgttcg gtggaggcac aaagctggaa ataaaacgg                             339





<210>  103

<211>  351

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Clone 86 Heavy chain coding sequence



<400>  103

gaggtgcagc tggaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60



tcctgtgcag cctctggatt cactttcagt gactatgcca tgtcttgggt tcgccagact      120



ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggtta cacctactat      180



ccagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240



ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagccttgat      300



gtttacttcg tggactactg gggccaaggc accacactca cagtctcctc a               351





