                               SEQUENCE LISTING

<110> ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
      ISTITUTO NAZIONALE TUMORI
 
<120> METHODS FOR DIAGNOSING AND TREATING INTRAHEPATIC 
      CHOLANGIOCARCINOMA

<130> 27527-0130WO1

<140>
<141>

<150> 61/876,451
<151> 2013-09-11

<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 3733
<212> DNA
<213> Homo sapiens

<400> 1
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg       60

gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc      120

aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg      180

cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg      240

cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga      300

gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc      360

atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg      420

gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa      480

aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca      540

gccgggggga acccaacgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag      600

gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt      660

gtggtcccat ctgacaaggg aaattatacc tgtgtggtgg agaatgaata cgggtccatc      720

aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc      780

ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt      840

tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa      900

tacgggcccg acgggctgcc ctacctcaag gttctcaagc actcggggat aaatagttcc      960

aatgcagaag tgctggctct gttcaatgtg accgaggcgg atgctgggga atatatatgt     1020

aaggtctcca attatatagg gcaggccaac cagtctgcct ggctcactgt cctgccaaaa     1080

cagcaagcgc ctggaagaga aaaggagatt acagcttccc cagactacct ggagatagcc     1140

atttactgca taggggtctt cttaatcgcc tgtatggtgg taacagtcat cctgtgccga     1200

atgaagaaca cgaccaagaa gccagacttc agcagccagc cggctgtgca caagctgacc     1260

aaacgtatcc ccctgcggag acaggtaaca gtttcggctg agtccagctc ctccatgaac     1320

tccaacaccc cgctggtgag gataacaaca cgcctctctt caacggcaga cacccccatg     1380

ctggcagggg tctccgagta tgaacttcca gaggacccaa aatgggagtt tccaagagat     1440

aagctgacac tgggcaagcc cctgggagaa ggttgctttg ggcaagtggt catggcggaa     1500

gcagtgggaa ttgacaaaga caagcccaag gaggcggtca ccgtggccgt gaagatgttg     1560

aaagatgatg ccacagagaa agacctttct gatctggtgt cagagatgga gatgatgaag     1620

atgattggga aacacaagaa tatcataaat cttcttggag cctgcacaca ggatgggcct     1680

ctctatgtca tagttgagta tgcctctaaa ggcaacctcc gagaatacct ccgagcccgg     1740

aggccacccg ggatggagta ctcctatgac attaaccgtg ttcctgagga gcagatgacc     1800

ttcaaggact tggtgtcatg cacctaccag ctggccagag gcatggagta cttggcttcc     1860

caaaaatgta ttcatcgaga tttagcagcc agaaatgttt tggtaacaga aaacaatgtg     1920

atgaaaatag cagactttgg actcgccaga gatatcaaca atatagacta ttacaaaaag     1980

accaccaatg ggcggcttcc agtcaagtgg atggctccag aagccctgtt tgatagagta     2040

tacactcatc agagtgatgt ctggtccttc ggggtgttaa tgtgggagat cttcacttta     2100

gggggctcgc cctacccagg gattcccgtg gaggaacttt ttaagctgct gaaggaagga     2160

cacagaatgg ataagccagc caactgcacc aacgaactgt acatgatgat gagggactgt     2220

tggcatgcag tgccctccca gagaccaacg ttcaagcagt tggtagaaga cttggatcga     2280

attctcactc tcacaaccaa tgaggatggc tacaatagac tagttaatat tgtgccaaag     2340

aaaccaccac tgctagacag acctggtgaa ggaagctaca atagatatta cagtcatgtt     2400

gattaccgag actatgacga gggccgcagt ttttctcatg atcgaagaag tggtccacct     2460

cacagaggag atgaatctgg ttatagatgg acaagagacg atcattctgc aagcaggcaa     2520

cctgaataca gggacatgag agatggcttt agaagaaaaa gtttctactc ttcccattat     2580

gcgagagagc ggtctcctta taaaagggac aatacttttt tcagagaatc acctgttggc     2640

cgaaaggatt ctccacacag cagatctggt tccagtgtca gtagcagaag ctactctcca     2700

gaaaggagca aatcatactc tttccatcag tctcaacata gaaagtccgt gcgtcctggt     2760

gcctcctaca aacggcagaa tgaaggaaat cctgaaagag ataaagagag gcctgtccag     2820

tctttgaaaa catcaagaga tacttcaccc tcaagtggtt cagcagtttc ttcatcaaag     2880

gtgttagaca aacccagtag gctaactgaa aaggaacttg ctgaggctgc aagcaagtgg     2940

gctgctgaaa agctagagaa atcagatgaa agtaacttgc ctgaaatttc tgagtatgag     3000

gcgggatcca cagcaccatt gtttactgac cagccagagg aacctgagtc aaacacaaca     3060

catgggatag aattatttga agatagtcag ctaaccactc gctctaaagc aatagcatca     3120

aaaaccaaag agattgaaca ggtttaccga caagactgtg aaactttcgg gatggtggtg     3180

aaaatgctga ttgaaaaaga tccttcatta gaaaagtcta tacagtttgc attgaggcag     3240

aatttacatg aaataggtga gcggtgtgtt gaagaactca agcatttcat tgcagagtat     3300

gatacttcca ctcaagattt tggagagcct ttttagattt ttctgctcag gctaaaaaaa     3360

aaaaaaaaca gtttctaaaa attttttttc ctggattgtg taaatcctta atatatggaa     3420

tttttgtgat gcagagaaat actttatgat agttgacaac atttcagtat taaataaaca     3480

tctaaaatag tctgtttaaa atgtttgatt caaatttttg tattttttgt agagatgggg     3540

ttcaccatgt tagccaggct agtctctaac tcctggcctc aagtgatctg cctgcctcag     3600

cctctcaaag tgttgagatt acaggcgtga gccaccgctc cctgcccaac acatatacca     3660

tctgaaaatg ttagaattct gagttgtgat tttattgact tgttgcttgc tttttcttag     3720

gctttgtaac ttg                                                        3733


<210> 2
<211> 4657
<212> DNA
<213> Homo sapiens

<400> 2
ggcggcggct ggaggagagc gcggtggaga gccgagcggg cgggcggcgg gtgcggagcg       60

ggcgagggag cgcgcgcggc cgccacaaag ctcgggcgcc gcggggctgc atgcggcgta      120

cctggcccgg cgcggcgact gctctccggg ctggcggggg ccggccgcga gccccggggg      180

ccccgaggcc gcagcttgcc tgcgcgctct gagccttcgc aactcgcgag caaagtttgg      240

tggaggcaac gccaagcctg agtcctttct tcctctcgtt ccccaaatcc gagggcagcc      300

cgcgggcgtc atgcccgcgc tcctccgcag cctggggtac gcgtgaagcc cgggaggctt      360

ggcgccggcg aagacccaag gaccactctt ctgcgtttgg agttgctccc cgcaaccccg      420

ggctcgtcgc tttctccatc ccgacccacg cggggcgcgg ggacaacaca ggtcgcggag      480

gagcgttgcc attcaagtga ctgcagcagc agcggcagcg cctcggttcc tgagcccacc      540

gcaggctgaa ggcattgcgc gtagtccatg cccgtagagg aagtgtgcag atgggattaa      600

cgtccacatg gagatatgga agaggaccgg ggattggtac cgtaaccatg gtcagctggg      660

gtcgtttcat ctgcctggtc gtggtcacca tggcaacctt gtccctggcc cggccctcct      720

tcagtttagt tgaggatacc acattagagc cagaagagcc accaaccaaa taccaaatct      780

ctcaaccaga agtgtacgtg gctgcgccag gggagtcgct agaggtgcgc tgcctgttga      840

aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc aacaatagga      900

cagtgcttat tggggagtac ttgcagataa agggcgccac gcctagagac tccggcctct      960

atgcttgtac tgccagtagg actgtagaca gtgaaacttg gtacttcatg gtgaatgtca     1020

cagatgccat ctcatccgga gatgatgagg atgacaccga tggtgcggaa gattttgtca     1080

gtgagaacag taacaacaag agagcaccat actggaccaa cacagaaaag atggaaaagc     1140

ggctccatgc tgtgcctgcg gccaacactg tcaagtttcg ctgcccagcc ggggggaacc     1200

caatgccaac catgcggtgg ctgaaaaacg ggaaggagtt taagcaggag catcgcattg     1260

gaggctacaa ggtacgaaac cagcactgga gcctcattat ggaaagtgtg gtcccatctg     1320

acaagggaaa ttatacctgt gtagtggaga atgaatacgg gtccatcaat cacacgtacc     1380

acctggatgt tgtggagcga tcgcctcacc ggcccatcct ccaagccgga ctgccggcaa     1440

atgcctccac agtggtcgga ggagacgtag agtttgtctg caaggtttac agtgatgccc     1500

agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac gggcccgacg     1560

ggctgcccta cctcaaggtt ctcaagcact cggggataaa tagttccaat gcagaagtgc     1620

tggctctgtt caatgtgacc gaggcggatg ctggggaata tatatgtaag gtctccaatt     1680

atatagggca ggccaaccag tctgcctggc tcactgtcct gccaaaacag caagcgcctg     1740

gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt tactgcatag     1800

gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg aagaacacga     1860

ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa cgtatccccc     1920

tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc aacaccccgc     1980

tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg gcaggggtct     2040

ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag ctgacactgg     2100

gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca gtgggaattg     2160

acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa gatgatgcca     2220

cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg attgggaaac     2280

acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc tatgtcatag     2340

ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg ccacccggga     2400

tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc aaggacttgg     2460

tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa aaatgtattc     2520

atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg aaaatagcag     2580

actttggact cgccagagat atcaacaata tagactatta caaaaagacc accaatgggc     2640

ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac actcatcaga     2700

gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg ggctcgccct     2760

acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac agaatggata     2820

agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg catgcagtgc     2880

cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt ctcactctca     2940

caaccaatga ggaatacttg gacctcagcc aacctctcga acagtattca cctagttacc     3000

ctgacacaag aagttcttgt tcttcaggag atgattctgt tttttctcca gaccccatgc     3060

cttacgaacc atgccttcct cagtatccac acataaacgg cagtgttaaa acatgaatga     3120

ctgtgtctgc ctgtccccaa acaggacagc actgggaacc tagctacact gagcagggag     3180

accatgcctc ccagagcttg ttgtctccac ttgtatatat ggatcagagg agtaaataat     3240

tggaaaagta atcagcatat gtgtaaagat ttatacagtt gaaaacttgt aatcttcccc     3300

aggaggagaa gaaggtttct ggagcagtgg actgccacaa gccaccatgt aacccctctc     3360

acctgccgtg cgtactggct gtggaccagt aggactcaag gtggacgtgc gttctgcctt     3420

ccttgttaat tttgtaataa ttggagaaga tttatgtcag cacacactta cagagcacaa     3480

atgcagtata taggtgctgg atgtatgtaa atatattcaa attatgtata aatatatatt     3540

atatatttac aaggagttat tttttgtatt gattttaaat ggatgtccca atgcacctag     3600

aaaattggtc tctctttttt taatagctat ttgctaaatg ctgttcttac acataatttc     3660

ttaattttca ccgagcagag gtggaaaaat acttttgctt tcagggaaaa tggtataacg     3720

ttaatttatt aataaattgg taatatacaa aacaattaat catttatagt tttttttgta     3780

atttaagtgg catttctatg caggcagcac agcagactag ttaatctatt gcttggactt     3840

aactagttat cagatccttt gaaaagagaa tatttacaat atatgactaa tttggggaaa     3900

atgaagtttt gatttatttg tgtttaaatg ctgctgtcag acgattgttc ttagacctcc     3960

taaatgcccc atattaaaag aactcattca taggaaggtg tttcattttg gtgtgcaacc     4020

ctgtcattac gtcaacgcaa cgtctaactg gacttcccaa gataaatggt accagcgtcc     4080

tcttaaaaga tgccttaatc cattccttga ggacagacct tagttgaaat gatagcagaa     4140

tgtgcttctc tctggcagct ggccttctgc ttctgagttg cacattaatc agattagcct     4200

gtattctctt cagtgaattt tgataatggc ttccagactc tttggcgttg gagacgcctg     4260

ttaggatctt caagtcccat catagaaaat tgaaacacag agttgttctg ctgatagttt     4320

tggggatacg tccatctttt taagggattg ctttcatcta attctggcag gacctcacca     4380

aaagatccag cctcatacct acatcagaca aaatatcgcc gttgttcctt ctgtactaaa     4440

gtattgtgtt ttgctttgga aacacccact cactttgcaa tagccgtgca agatgaatgc     4500

agattacact gatcttatgt gttacaaaat tggagaaagt atttaataaa acctgttaat     4560

ttttatactg acaataaaaa tgtttctaca gatattaatg ttaacaagac aaaataaatg     4620

tcacgcaact tattttttta ataaaaaaaa aaaaaaa                              4657


<210> 3
<211> 1677
<212> DNA
<213> Homo sapiens

<400> 3
attgcgcgcg ccggaagtac ctacctggga taacggcggc gagcggacgg ctgcatttac       60

ggggtctccc ggagggccag agtcgtggct tacagaagag acgaaatgtg gtctgaggga      120

cgatatgaat atgaaagaat tccgagagaa cgagcacctc ctcgaagtca tcccagtgat      180

ggctacaata gactagttaa tattgtgcca aagaaaccac cactgctaga cagacctggt      240

gaaggaagct acaatagata ttacagtcat gttgattacc gagactatga cgagggccgc      300

agtttttctc atgatcgaag aagtggtcca cctcacagag gagatgaatc tggttataga      360

tggacaagag acgatcattc tgcaagcagg caacctgaat acagggacat gagagatggc      420

tttagaagaa aaagtttcta ctcttcccat tatgcgagag agcggtctcc ttataaaagg      480

gacaatactt ttttcagaga atcacctgtt ggccgaaagg attctccaca cagcagatct      540

ggttccagtg tcagtagcag aagctactct ccagaaagga gcaaatcata ctctttccat      600

cagtctcaac atagaaagtc cgtgcgtcct ggtgcctcct acaaacggca gaatgaagga      660

aatcctgaaa gagataaaga gaggcctgtc cagtctttga aaacatcaag agatacttca      720

ccctcaagtg gttcagcagt ttcttcatca aaggtgttag acaaacccag taggctaact      780

gaaaaggaac ttgctgaggc tgcaagcaag tgggctgctg aaaagctaga gaaatcagat      840

gaaagtaact tgcctgaaat ttctgagtat gaggcgggat ccacagcacc attgtttact      900

gaccagccag aggaacctga gtcaaacaca acacatggga tagaattatt tgaagatagt      960

cagctaacca ctcgctctaa agcaatagca tcaaaaacca aagagattga acaggtttac     1020

cgacaagact gtgaaacttt cgggatggtg gtgaaaatgc tgattgaaaa agatccttca     1080

ttagaaaagt ctatacagtt tgcattgagg cagaatttac atgaaatagg tgagcggtgt     1140

gttgaagaac tcaagcattt cattgcagag tatgatactt ccactcaaga ttttggagag     1200

cctttttaga tttttctgct caggctaaaa aaaaaaaaaa acagtttcta aaaatttttt     1260

ttcctggatt gtgtaaatcc ttaatatatg gaatttttgt gatgcagaga aatactttat     1320

gatagttgac aacatttcag tattaaataa acatctaaaa tagtctgttt aaaatgtttg     1380

attcaaattt ttgtattttt tgtagagatg gggttcacca tgttggccag gctagtctct     1440

aactcctggc ctcaagtgat ctgcctgcct cagcctctca aagtgttgag attacaggcg     1500

tgagccaccg ctccctgccc aacacatata ccatctgaaa atgttagaat tctgagttgt     1560

gattttattg acttgttgct tgctttttct taggctttgt aacttgtaat atgttaaagt     1620

gtactatcct aataaactga atactttggt atcttagaga ataaaaaaaa aaaaaaa        1677


<210> 4
<211> 2781
<212> DNA
<213> Homo sapiens

<400> 4
tgactgcagc agcagcggca gcgcctcggt tcctgagccc accgcaggct gaaggcattg       60

cgcgtagtcc atgcccgtag aggaagtgtg cagatgggat taacgtccac atggagatat      120

ggaagaggac cggggattgg taccgtaacc atggtcagct ggggtcgttt catctgcctg      180

gtcgtggtca ccatggcaac cttgtccctg gcccggccct ccttcagttt agttgaggat      240

accacattag agccagaaga gccaccaacc aaataccaaa tctctcaacc agaagtgtac      300

gtggctgcgc caggggagtc gctagaggtg cgctgcctgt tgaaagatgc cgccgtgatc      360

agttggacta aggatggggt gcacttgggg cccaacaata ggacagtgct tattggggag      420

tacttgcaga taaagggcgc cacgcctaga gactccggcc tctatgcttg tactgccagt      480

aggactgtag acagtgaaac ttggtacttc atggtgaatg tcacagatgc catctcatcc      540

ggagatgatg aggatgacac cgatggtgcg gaagattttg tcagtgagaa cagtaacaac      600

aagagagcac catactggac caacacagaa aagatggaaa agcggctcca tgctgtgcct      660

gcggccaaca ctgtcaagtt tcgctgccca gccgggggga acccaatgcc aaccatgcgg      720

tggctgaaaa acgggaagga gtttaagcag gagcatcgca ttggaggcta caaggtacga      780

aaccagcact ggagcctcat tatggaaagt gtggtcccat ctgacaaggg aaattatacc      840

tgtgtagtgg agaatgaata cgggtccatc aatcacacgt accacctgga tgttgtggag      900

cgatcgcctc accggcccat cctccaagcc ggactgccgg caaatgcctc cacagtggtc      960

ggaggagacg tagagtttgt ctgcaaggtt tacagtgatg cccagcccca catccagtgg     1020

atcaagcacg tggaaaagaa cggcagtaaa tacgggcccg acgggctgcc ctacctcaag     1080

gttctcaagc actcggggat aaatagttcc aatgcagaag tgctggctct gttcaatgtg     1140

accgaggcgg atgctgggga atatatatgt aaggtctcca attatatagg gcaggccaac     1200

cagtctgcct ggctcactgt cctgccaaaa cagcaagcgc ctggaagaga aaaggagatt     1260

acagcttccc cagactacct ggagatagcc atttactgca taggggtctt cttaatcgcc     1320

tgtatggtgg taacagtcat cctgtgccga atgaagaaca cgaccaagaa gccagacttc     1380

agcagccagc cggctgtgca caagctgacc aaacgtatcc ccctgcggag acaggtaaca     1440

gtttcggctg agtccagctc ctccatgaac tccaacaccc cgctggtgag gataacaaca     1500

cgcctctctt caacggcaga cacccccatg ctggcagggg tctccgagta tgaacttcca     1560

gaggacccaa aatgggagtt tccaagagat aagctgacac tgggcaagcc cctgggagaa     1620

ggttgctttg ggcaagtggt catggcggaa gcagtgggaa ttgacaaaga caagcccaag     1680

gaggcggtca ccgtggccgt gaagatgttg aaagatgatg ccacagagaa agacctttct     1740

gatctggtgt cagagatgga gatgatgaag atgattggga aacacaagaa tatcataaat     1800

cttcttggag cctgcacaca ggatgggcct ctctatgtca tagttgagta tgcctctaaa     1860

ggcaacctcc gagaatacct ccgagcccgg aggccacccg ggatggagta ctcctatgac     1920

attaaccgtg ttcctgagga gcagatgacc ttcaaggact tggtgtcatg cacctaccag     1980

ctggccagag gcatggagta cttggcttcc caaaaatgta ttcatcgaga tttagcagcc     2040

agaaatgttt tggtaacaga aaacaatgtg atgaaaatag cagactttgg actcgccaga     2100

gatatcaaca atatagacta ttacaaaaag accaccaatg ggcggcttcc agtcaagtgg     2160

atggctccag aagccctgtt tgatagagta tacactcatc agagtgatgt ctggtccttc     2220

ggggtgttaa tgtgggagat cttcacttta gggggctcgc cctacccagg gattcccgtg     2280

gaggaacttt ttaagctgct gaaggaagga cacagaatgg ataagccagc caactgcacc     2340

aacgaactgt acatgatgat gagggactgt tggcatgcag tgccctccca gagaccaacg     2400

ttcaagcagt tggtagaaga cttggatcga attctcactc tcacaaccaa tgagatctga     2460

aagtttatgg cttcattgag aaactgggaa aagttggtca ggcgcagtgg ctcatgcctg     2520

taatcccagc actttgggag gccgaggcag gcggatcatg aggtcaggag ttccagacca     2580

gcctggccaa catggtgaaa ccctgtctct actaaagata caaaaaatta gccgggcgtg     2640

ttggtgtgca cctgtaatcc cagctactcc gggaggctga ggcaggagag tcacttgaac     2700

cggggaggcg gaggttgcag tgagccgaga tcatgccatt gcattccagc cttggcgaca     2760

gagcgagact ccgtctcaaa a                                               2781


<210> 5
<211> 1111
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Asp Gly Tyr Asn Arg Leu Val Asn Ile Val Pro Lys Lys Pro Pro Leu 
    770                 775                 780                 


Leu Asp Arg Pro Gly Glu Gly Ser Tyr Asn Arg Tyr Tyr Ser His Val 
785                 790                 795                 800 


Asp Tyr Arg Asp Tyr Asp Glu Gly Arg Ser Phe Ser His Asp Arg Arg 
                805                 810                 815     


Ser Gly Pro Pro His Arg Gly Asp Glu Ser Gly Tyr Arg Trp Thr Arg 
            820                 825                 830         


Asp Asp His Ser Ala Ser Arg Gln Pro Glu Tyr Arg Asp Met Arg Asp 
        835                 840                 845             


Gly Phe Arg Arg Lys Ser Phe Tyr Ser Ser His Tyr Ala Arg Glu Arg 
    850                 855                 860                 


Ser Pro Tyr Lys Arg Asp Asn Thr Phe Phe Arg Glu Ser Pro Val Gly 
865                 870                 875                 880 


Arg Lys Asp Ser Pro His Ser Arg Ser Gly Ser Ser Val Ser Ser Arg 
                885                 890                 895     


Ser Tyr Ser Pro Glu Arg Ser Lys Ser Tyr Ser Phe His Gln Ser Gln 
            900                 905                 910         


His Arg Lys Ser Val Arg Pro Gly Ala Ser Tyr Lys Arg Gln Asn Glu 
        915                 920                 925             


Gly Asn Pro Glu Arg Asp Lys Glu Arg Pro Val Gln Ser Leu Lys Thr 
    930                 935                 940                 


Ser Arg Asp Thr Ser Pro Ser Ser Gly Ser Ala Val Ser Ser Ser Lys 
945                 950                 955                 960 


Val Leu Asp Lys Pro Ser Arg Leu Thr Glu Lys Glu Leu Ala Glu Ala 
                965                 970                 975     


Ala Ser Lys Trp Ala Ala Glu Lys Leu Glu Lys Ser Asp Glu Ser Asn 
            980                 985                 990         


Leu Pro Glu Ile Ser Glu Tyr Glu  Ala Gly Ser Thr Ala  Pro Leu Phe 
        995                 1000                 1005             


Thr Asp  Gln Pro Glu Glu Pro  Glu Ser Asn Thr Thr  His Gly Ile 
    1010                 1015                 1020             


Glu Leu  Phe Glu Asp Ser Gln  Leu Thr Thr Arg Ser  Lys Ala Ile 
    1025                 1030                 1035             


Ala Ser  Lys Thr Lys Glu Ile  Glu Gln Val Tyr Arg  Gln Asp Cys 
    1040                 1045                 1050             


Glu Thr  Phe Gly Met Val Val  Lys Met Leu Ile Glu  Lys Asp Pro 
    1055                 1060                 1065             


Ser Leu  Glu Lys Ser Ile Gln  Phe Ala Leu Arg Gln  Asn Leu His 
    1070                 1075                 1080             


Glu Ile  Gly Glu Arg Cys Val  Glu Glu Leu Lys His  Phe Ile Ala 
    1085                 1090                 1095             


Glu Tyr  Asp Thr Ser Thr Gln  Asp Phe Gly Glu Pro  Phe 
    1100                 1105                 1110     


<210> 6
<211> 822
<212> PRT
<213> Homo sapiens

<400> 6
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Glu Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr 
    770                 775                 780                 


Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser 
785                 790                 795                 800 


Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile 
                805                 810                 815     


Asn Gly Ser Val Lys Thr 
            820         


<210> 7
<211> 367
<212> PRT
<213> Homo sapiens

<400> 7
Met Trp Ser Glu Gly Arg Tyr Glu Tyr Glu Arg Ile Pro Arg Glu Arg 
1               5                   10                  15      


Ala Pro Pro Arg Ser His Pro Ser Asp Gly Tyr Asn Arg Leu Val Asn 
            20                  25                  30          


Ile Val Pro Lys Lys Pro Pro Leu Leu Asp Arg Pro Gly Glu Gly Ser 
        35                  40                  45              


Tyr Asn Arg Tyr Tyr Ser His Val Asp Tyr Arg Asp Tyr Asp Glu Gly 
    50                  55                  60                  


Arg Ser Phe Ser His Asp Arg Arg Ser Gly Pro Pro His Arg Gly Asp 
65                  70                  75                  80  


Glu Ser Gly Tyr Arg Trp Thr Arg Asp Asp His Ser Ala Ser Arg Gln 
                85                  90                  95      


Pro Glu Tyr Arg Asp Met Arg Asp Gly Phe Arg Arg Lys Ser Phe Tyr 
            100                 105                 110         


Ser Ser His Tyr Ala Arg Glu Arg Ser Pro Tyr Lys Arg Asp Asn Thr 
        115                 120                 125             


Phe Phe Arg Glu Ser Pro Val Gly Arg Lys Asp Ser Pro His Ser Arg 
    130                 135                 140                 


Ser Gly Ser Ser Val Ser Ser Arg Ser Tyr Ser Pro Glu Arg Ser Lys 
145                 150                 155                 160 


Ser Tyr Ser Phe His Gln Ser Gln His Arg Lys Ser Val Arg Pro Gly 
                165                 170                 175     


Ala Ser Tyr Lys Arg Gln Asn Glu Gly Asn Pro Glu Arg Asp Lys Glu 
            180                 185                 190         


Arg Pro Val Gln Ser Leu Lys Thr Ser Arg Asp Thr Ser Pro Ser Ser 
        195                 200                 205             


Gly Ser Ala Val Ser Ser Ser Lys Val Leu Asp Lys Pro Ser Arg Leu 
    210                 215                 220                 


Thr Glu Lys Glu Leu Ala Glu Ala Ala Ser Lys Trp Ala Ala Glu Lys 
225                 230                 235                 240 


Leu Glu Lys Ser Asp Glu Ser Asn Leu Pro Glu Ile Ser Glu Tyr Glu 
                245                 250                 255     


Ala Gly Ser Thr Ala Pro Leu Phe Thr Asp Gln Pro Glu Glu Pro Glu 
            260                 265                 270         


Ser Asn Thr Thr His Gly Ile Glu Leu Phe Glu Asp Ser Gln Leu Thr 
        275                 280                 285             


Thr Arg Ser Lys Ala Ile Ala Ser Lys Thr Lys Glu Ile Glu Gln Val 
    290                 295                 300                 


Tyr Arg Gln Asp Cys Glu Thr Phe Gly Met Val Val Lys Met Leu Ile 
305                 310                 315                 320 


Glu Lys Asp Pro Ser Leu Glu Lys Ser Ile Gln Phe Ala Leu Arg Gln 
                325                 330                 335     


Asn Leu His Glu Ile Gly Glu Arg Cys Val Glu Glu Leu Lys His Phe 
            340                 345                 350         


Ile Ala Glu Tyr Asp Thr Ser Thr Gln Asp Phe Gly Glu Pro Phe 
        355                 360                 365         


<210> 8
<211> 13
<212> PRT
<213> Homo sapiens

<400> 8
Ile Phe Leu Leu Arg Leu Lys Lys Lys Lys Asn Ser Phe 
1               5                   10              


<210> 9
<211> 90
<212> DNA
<213> Homo sapiens

<400> 9
tgccttgcag cctctttcta ggtgtatata aacatacact gttttcaggt ctacttaatt       60

tagtaattca gttatataca tattccatat                                        90


<210> 10
<211> 28
<212> DNA
<213> Homo sapiens

<400> 10
tcacaaccaa tgaggatggc tacaatag                                          28


<210> 11
<211> 769
<212> PRT
<213> Homo sapiens

<400> 11
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile Asn Ser Ser 
305                 310                 315                 320 


Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala Asp Ala Gly 
                325                 330                 335     


Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala Asn Gln Ser 
            340                 345                 350         


Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Gly Arg Glu Lys 
        355                 360                 365             


Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile 
    370                 375                 380                 


Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg 
385                 390                 395                 400 


Met Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val 
                405                 410                 415     


His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser 
            420                 425                 430         


Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
        435                 440                 445             


Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val 
    450                 455                 460                 


Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp 
465                 470                 475                 480 


Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
                485                 490                 495     


Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala 
            500                 505                 510         


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp 
        515                 520                 525             


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
    530                 535                 540                 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro 
545                 550                 555                 560 


Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr 
                565                 570                 575     


Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn 
            580                 585                 590         


Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr 
        595                 600                 605             


Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
    610                 615                 620                 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val 
625                 630                 635                 640 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp 
                645                 650                 655     


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
            660                 665                 670         


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
        675                 680                 685             


Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
    690                 695                 700                 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
705                 710                 715                 720 


His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met 
                725                 730                 735     


Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
            740                 745                 750         


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu 
        755                 760                 765             


Ile 
    


<210> 12
<211> 50
<212> RNA
<213> Homo sapiens

<400> 12
cgaauucuca cucucacaac caaugaggau ggcuacaaua gacuaguuaa                  50


<210> 13
<211> 90
<212> DNA
<213> Homo sapiens

<400> 13
atatggaata tgtatataac tgaattacta aattaagtag acctgaaaac agtgtatgtt       60

tatatacacc tagaaagagg ctgcaaggca                                        90


<210> 14
<211> 50
<212> DNA
<213> Homo sapiens

<400> 14
cgaattctca ctctcacaac caatgaggat ggctacaata gactagttaa                  50


<210> 15
<211> 50
<212> DNA
<213> Homo sapiens

<400> 15
ttaactagtc tattgtagcc atcctcattg gttgtgagag tgagaattcg                  50


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
atcctgggct acactgagca                                                   20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
tgacaaagtg gtcgttgagg                                                   20


<210> 18
<211> 70
<212> PRT
<213> Homo sapiens

<400> 18
Leu Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg 
1               5                   10                  15      


Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu 
            20                  25                  30          


Thr Thr Asn Glu Asp Gly Tyr Asn Arg Leu Val Asn Ile Val Pro Lys 
        35                  40                  45              


Lys Pro Pro Leu Leu Asp Arg Pro Gly Glu Gly Ser Tyr Asn Arg Tyr 
    50                  55                  60                  


Tyr Ser His Val Asp Tyr 
65                  70  


<210> 19
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
cagttggtag aagacttgga tcg                                               23


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ggtggtttct ttggcacaat                                                   20


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
tgatgatgag ggactgttgg                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
ggtggtttct ttggcacaat                                                   20


<210> 23
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
cggggattgg taccgtaa                                                     18


<210> 24
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
ttacaagtta caaagcctaa gaaaaag                                           27


<210> 25
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
ggggacaagt ttgtacaaaa aagcaggctt catggtcagc tggggtcgtt tca              53


<210> 26
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ggggaccact ttgtacaaga aagctgggtt caagttacaa agcctaagaa aaagcaagc        59


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
tcactctcac aaccaatgag                                                   20


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
tgttggggca taaaaagaac a                                                 21


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
acgtcttgct cgagatgtga                                                   20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
aatccagcag gtcagcaaag                                                   20


<210> 31
<211> 733
<212> DNA
<213> Homo sapiens

<400> 31
ggatcgaatt ctcactctca caaccaatga ggtaagaact tccttttaga agccccttgt       60

ccttggttgt cttgtgagac atgcgtagtg tttacacaca cactcccctg tttggctgtt      120

ggttggagtc tgtggggtct tgtttattct ttttccatag ggtcagatag ttcaactatg      180

ggttcctctc aaatcatgat ttttctcaga acttcatttt gtgacttctg actcatgaaa      240

ccaaagacag agggacatcc ccgaggctgc cttcagtgta gctgctggtg gagcaagtcc      300

ggggtatgtg ggagagtggg aaaggggaag cagtattcac ttgcattttg gtgtgcatgg      360

gaaaaagctt ggattcctgt gcaagtttga ttctgtgctt tggtcattag tgggtaactg      420

ataatgttcg tcatcatttg cttgatggaa tacaatgaag ttttgtaaca ccagcttctg      480

ttaccacagt actatcctat gtgatcctgt tggtaatgct gtatgccttg cagcctcttt      540

ctaggtgtat ataaacatac actgttttca ggtctactta atttagtaat tcagttatat      600

acatattcca tataacattg tttaaaatgt attaatgttg aaatattttt tctttccatt      660

cttatttcat gaaacacttt tattcaaaat cttcacaggc atatttaaat ttctgttctt      720

tttatgcccc aca                                                         733


<210> 32
<211> 28
<212> DNA
<213> Homo sapiens

<400> 32
ctattgtagc catcctcatt ggttgtga                                          28


<210> 33
<211> 10
<212> PRT
<213> Homo sapiens

<400> 33
Lys Phe Phe Phe Leu Asp Cys Val Asn Pro 
1               5                   10  


<210> 34
<211> 5
<212> PRT
<213> Homo sapiens

<400> 34
Tyr Met Glu Phe Leu 
1               5   


<210> 35
<211> 8
<212> PRT
<213> Homo sapiens

<400> 35
Cys Arg Glu Ile Leu Tyr Asp Ser 
1               5               


<210> 36
<211> 6
<212> PRT
<213> Homo sapiens

<400> 36
Gln His Phe Ser Ile Lys 
1               5       


<210> 37
<211> 50
<212> PRT
<213> Homo sapiens

<400> 37
Thr Ser Lys Ile Val Cys Leu Lys Cys Leu Ile Gln Ile Phe Val Phe 
1               5                   10                  15      


Phe Val Glu Met Gly Phe Thr Met Leu Ala Arg Leu Val Ser Asn Ser 
            20                  25                  30          


Trp Pro Gln Val Ile Cys Leu Pro Gln Pro Leu Lys Val Leu Arg Leu 
        35                  40                  45              


Gln Ala 
    50  


<210> 38
<211> 29
<212> PRT
<213> Homo sapiens

<400> 38
Ala Thr Ala Pro Cys Pro Thr His Ile Pro Ser Glu Asn Val Arg Ile 
1               5                   10                  15      


Leu Ser Cys Asp Phe Ile Asp Leu Leu Leu Ala Phe Ser 
            20                  25                  


