
                                SEQUENCE LISTING

<110> Halozyme, Inc. et al.

<120> MODIFIED ANTI-EPIDERMAL GROWTH FACTOR
  RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF
  

<130> 33320.03118.US01/3118

<140> Not Yet Assigned    
<141> Herewith         

<150> US 61/960,253       
<151> 2013-09-12  

<160> 394

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A119 R216 heavy chain

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 1
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 2
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A119 heavy chain variable domain
      

<400> 2
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 3
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A100 LELK104-107 A213 light chain
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(213)
<223> constant domain

<400> 3
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Ala
    210             


<210> 4
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A100 LELK104-107 light chain variable
      domain
      

<400> 4
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 5
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A119 R216 Ins222PKS heavy chain
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(235)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (236)...(345)
<223> CH2


<220> 
<221> DOMAIN         
<222> (346)...(452)
<223> CH3

<400> 5
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Pro Lys Ser
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 6
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab S119 K216 heavy chain
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 6
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 7
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab S119 heavy chain variable domain
      

<400> 7
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 8
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab Q100 VEIK104-107 EC213-214 light chain
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 8
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab Q100 VEIK104-107 light chain variable
      domain
      

<400> 9
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 10
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab Q100 LELK104-107 A213 light chain
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(213)
<223> constant domain

<400> 10
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Ala
    210             


<210> 11
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab Q100 LELK104-107 light chain variable
      domain
      

<400> 11
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 12
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A119 R216 E358 M360 heavy chain

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 12
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 13
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A100 LELK104-107 EC213-214 light chain
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 13
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 14
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized Cetuximab (H225) heavy chain variable
      domain
      

<400> 14
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Met Val Thr Val Ser Ser
        115                 


<210> 15
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized Cetuximab (H225) light chain variable
      domain
      

<400> 15
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 16
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized Cetuximab (Hu225) Heavy Chain Variable
      domain
      

<400> 16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Asn Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 17
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized Cetuximab (Hu225) Light Chain Variable
      domain
      

<400> 17
Asp Ile Leu Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 18
<211> 457
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab S119 K216 Heavy Chain with Flag Tag
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(449)
<223> constant domain

<220> 
<221> PEPTIDE        
<222> (450)...(457)
<223> Flag tag

<400> 18
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys Asp Tyr Lys Asp Asp Asp Asp Lys
    450                 455         


<210> 19
<211> 330
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG1
      

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(113)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (114)...(223)
<223> CH2

<220> 
<221> DOMAIN         
<222> (224)...(328)
<223> CH3

<400> 19
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 20
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab R216 heavy chain constant domain
      

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(113)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (114)...(223)
<223> CH2

<220> 
<221> DOMAIN         
<222> (224)...(328)
<223> CH3

<400> 20
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 21
<211> 333
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab R216 Ins222PKS heavy chain constant
      domain
      

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(116)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (117)...(226)
<223> CH2

<220> 
<221> DOMAIN         
<222> (227)...(331)
<223> CH3

<400> 21
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys
            100                 105                 110         
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
        115                 120                 125             
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
    130                 135                 140                 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
145                 150                 155                 160 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
                165                 170                 175     
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
            180                 185                 190         
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
        195                 200                 205             
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
    210                 215                 220                 
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
225                 230                 235                 240 
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                245                 250                 255     
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
            260                 265                 270         
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
        275                 280                 285             
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
    290                 295                 300                 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
305                 310                 315                 320 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330             


<210> 22
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab K216 heavy chain constant domain
      

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(113)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (114)...(223)
<223> CH2

<220> 
<221> DOMAIN         
<222> (224)...(328)
<223> CH3

<400> 22
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 23
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab R216 E358 M360 heavy chain constant
      domain
      

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(113)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (114)...(223)
<223> CH2

<220> 
<221> DOMAIN         
<222> (224)...(328)
<223> CH3

<400> 23
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 24
<211> 326
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG2

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(110)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (111)...(219)
<223> CH2

<220> 
<221> DOMAIN         
<222> (220)...(326)
<223> CH3

<400> 24
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 25
<211> 377
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG3
      

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(160)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (161)...(270)
<223> CH2

<220> 
<221> DOMAIN         
<222> (271)...(376)
<223> CH3

<400> 25
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro
            100                 105                 110         
Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg
        115                 120                 125             
Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys
    130                 135                 140                 
Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro
145                 150                 155                 160 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                165                 170                 175     
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            180                 185                 190         
Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr
        195                 200                 205             
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    210                 215                 220                 
Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
225                 230                 235                 240 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                245                 250                 255     
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            260                 265                 270         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        275                 280                 285             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    290                 295                 300                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn
305                 310                 315                 320 
Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                325                 330                 335     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile
            340                 345                 350         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln
        355                 360                 365             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    370                 375         


<210> 26
<211> 327
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG4
      

<220> 
<221> DOMAIN         
<222> (1)...(98)
<223> CH1

<220> 
<221> DOMAIN         
<222> (99)...(110)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (111)...(220)
<223> CH2

<220> 
<221> DOMAIN         
<222> (221)...(327)
<223> CH3

<400> 26
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 27
<211> 231
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG1 Fc
      

<400> 27
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
 1               5                  10                  15      
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            20                  25                  30          
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        35                  40                  45              
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
    50                  55                  60                  
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
65                  70                  75                  80  
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                85                  90                  95      
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            100                 105                 110         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        115                 120                 125             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
    130                 135                 140                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
145                 150                 155                 160 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                165                 170                 175     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            180                 185                 190         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        195                 200                 205             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    210                 215                 220                 
Leu Ser Leu Ser Pro Gly Lys
225                 230     


<210> 28
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG1 native C-terminus of Fc domain
      

<400> 28
Glu Pro Arg Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Asp Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Met Gln Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Arg
145                 150                 155                 160 
His Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 29
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cetuximab A119 R216 E358 M360 heavy chain DNA
      
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 29
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatt acgagtttgc ttactggggc caagggactc tggtcactgt ctctgcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtcccc gggtaaa                                     1347

<210> 30
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cetuximab A100 LELK104-107 EC213-214 light chain
      DNA
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 30
gacatcttgc tgactcagtc tccagtcatc ctgtctgtga gtccaggaga aagagtcagt 60
ttctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcaaagaaca 120
aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc 180
aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct 240
gaagatattg cagattatta ctgtcaacaa aataataact ggccaaccac gttcggtgct 300
gggaccaagc tggagctgaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 31
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> human kappa light chain constant domain
      

<400> 31
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         


<210> 32
<211> 104
<212> PRT
<213> Homo sapiens

<220> 
<223> human lambda light chain constant domain
      

<400> 32
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu
 1               5                  10                  15      
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
            20                  25                  30          
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val
        35                  40                  45              
Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys
    50                  55                  60                  
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
65                  70                  75                  80  
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
                85                  90                  95      
Lys Thr Val Ala Pro Thr Glu Cys
            100                 


<210> 33
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab A213 kappa light chain constant domain
      

<400> 33
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Ala
            100                 105     


<210> 34
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab EC213-214 light chain constant domain
      

<400> 34
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab CDRH1
      

<400> 35
Asn Tyr Gly Val His
 1               5  


<210> 36
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab CDRH2
      

<400> 36
Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser
 1               5                  10                  15      


<210> 37
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab CDRH3
      

<400> 37
Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr
 1               5                  10      


<210> 38
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab CDRL1
      

<400> 38
Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His
 1               5                  10      


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab CDRL2
      

<400> 39
Tyr Ala Ser Glu Ser Ile Ser
 1               5          


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Cetuximab CDRL3
      

<400> 40
Gln Gln Asn Asn Asn Trp Pro Thr Thr
 1               5                  


<210> 41
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Heavy chain signal sequence

<400> 41
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15      
Val Gln Cys
            


<210> 42
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Light chain signal sequence

<400> 42
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Gly Ala Lys Cys
            20          


<210> 43
<211> 1210
<212> PRT
<213> Homo sapiens

<220> 
<223> epidermal growth factor receptor (EGFR)
      

<400> 43
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
            20                  25                  30          
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
        35                  40                  45              
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
    50                  55                  60                  
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65                  70                  75                  80  
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
                85                  90                  95      
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
            100                 105                 110         
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
        115                 120                 125             
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
    130                 135                 140                 
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145                 150                 155                 160 
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
                165                 170                 175     
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
            180                 185                 190         
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
        195                 200                 205             
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
    210                 215                 220                 
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225                 230                 235                 240 
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
                245                 250                 255     
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
            260                 265                 270         
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
        275                 280                 285             
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
    290                 295                 300                 
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305                 310                 315                 320 
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
                325                 330                 335     
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
            340                 345                 350         
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
        355                 360                 365             
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
    370                 375                 380                 
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385                 390                 395                 400 
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
                405                 410                 415     
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
            420                 425                 430         
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
        435                 440                 445             
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
    450                 455                 460                 
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465                 470                 475                 480 
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu
                485                 490                 495     
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
            500                 505                 510         
Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn
        515                 520                 525             
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
    530                 535                 540                 
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545                 550                 555                 560 
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
                565                 570                 575     
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
            580                 585                 590         
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
        595                 600                 605             
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
    610                 615                 620                 
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625                 630                 635                 640 
Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu
                645                 650                 655     
Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His
            660                 665                 670         
Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu
        675                 680                 685             
Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu
    690                 695                 700                 
Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser
705                 710                 715                 720 
Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu
                725                 730                 735     
Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser
            740                 745                 750         
Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser
        755                 760                 765             
Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser
    770                 775                 780                 
Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp
785                 790                 795                 800 
Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn
                805                 810                 815     
Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg
            820                 825                 830         
Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro
        835                 840                 845             
Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala
    850                 855                 860                 
Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp
865                 870                 875                 880 
Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp
                885                 890                 895     
Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser
            900                 905                 910         
Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu
        915                 920                 925             
Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr
    930                 935                 940                 
Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys
945                 950                 955                 960 
Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln
                965                 970                 975     
Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro
            980                 985                 990         
Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp
        995                 1000                1005            
Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe
    1010                1015                1020                
Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala
1025                1030                1035               1040 
Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln
                1045                1050                1055    
Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp
            1060                1065                1070        
Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro
        1075                1080                1085            
Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser
    1090                1095                1100                
Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser
1105                1110                1115               1120 
Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro
                1125                1130                1135    
Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp
            1140                1145                1150        
Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp
        1155                1160                1165            
Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn
    1170                1175                1180                
Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val
1185                1190                1195               1200 
Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala
                1205                1210


<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> His tag

<400> 44
His His His His His His
 1               5      


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flag tag

<400> 45
Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5              


<210> 46
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> (Gly4Ser)3 Linker

<400> 46
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 47
<211> 4136
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cetuximab heavy chain S119 K216/light chain Q100
      VEIK104-107 EC213-214 DNA
      

<220> 
<221> sig_peptide    
<222> (1109)...(1174)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1175)...(1495)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1496)...(1816)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1859)...(2433)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2447)...(2503)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2504)...(2860)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2861)...(3850)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3851)...(3874)
<223> Flag tag

<400> 47
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caattggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg 660
cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata 720
agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac 780
agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt 840
gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 900
ggttacaaga caggtttaag gtgaccaata gaaactgggc ttgtcgagac agagaagact 960
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 1020
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1080
ataggctagt ctcgtcgacg agactagcat ggacatgagg gtccccgctc agctcctggg 1140
gctcctgctg ctctggctcc caggtgccaa gtgtgacatc ttgctgactc agtctccagt 1200
catcctgtct gtgagtccag gagaaagagt cagtttctcc tgcagggcca gtcagagtat 1260
tggcacaaac atacactggt atcagcaaag aacaaatggt tctccaaggc ttctcataaa 1320
gtatgcttct gagtctatct ctgggatccc ttccaggttt agtggcagtg gatcagggac 1380
agattttact cttagcatca acagtgtgga gtctgaagat attgcagatt attactgtca 1440
acaaaataat aactggccaa ccacgttcgg ccaagggacc aaggtggaaa tcaaacgtac 1500
ggtggctgca ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac 1560
tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa 1620
ggtggataac gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa 1680
ggacagcacc tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca 1740
caaagtctac gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt 1800
caacagggga gagtgttgac tcgaggcgcg ccgagcatgc atctagggcg gccaattccg 1860
cccctctccc cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt 1920
gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg 1980
aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga 2040
atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa 2100
acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc 2160
tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac 2220
gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag 2280
gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc 2340
acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg 2400
gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccatgg agtttgggct 2460
gagctggctt tttcttgtgg ctattttaaa aggtgtccag tgtcaggtgc agctgaagca 2520
gtcaggacct ggcctagtgc agccctcaca gagcctgtcc atcacctgca cagtctctgg 2580
tttctcatta actaactatg gtgtacactg ggttcgccag tctccaggaa agggtctgga 2640
gtggctggga gtgatatgga gtggtggaaa cacagactat aatacacctt tcacatccag 2700
actgagcatc aacaaggaca attccaagag ccaagttttc tttaaaatga acagtctgca 2760
atctaatgac acagccatat attactgtgc cagagccctc acctactatg attacgagtt 2820
tgcttactgg ggccagggaa cgctggtcac cgtcagctca gcctccacca agggcccatc 2880
ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg 2940
cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac 3000
cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag 3060
cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca 3120
caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca 3180
cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc 3240
cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt 3300
ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt 3360
gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag 3420
cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtcag 3480
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg 3540
agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag 3600
cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa 3660
tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt 3720
cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc 3780
atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc 3840
tccgggtaaa gattacaagg atgacgacga taagtgagcg gccgcttccc tttagtgagg 3900
gttaatgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag 3960
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 4020
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 4080
tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggta     4136

<210> 48
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cetuximab heavy chain S119 K216 DNA
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 48
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatt acgagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 49
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cetuximab heavy chain S119 variable domain DNA
      

<400> 49
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatt acgagtttgc ttactggggc cagggaacgc tggtcaccgt cagctca    357

<210> 50
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cetuximab Q100 VEIK104-107 EC213-214 light chain
      DNA
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 50
gacatcttgc tgactcagtc tccagtcatc ctgtctgtga gtccaggaga aagagtcagt 60
ttctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcaaagaaca 120
aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc 180
aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct 240
gaagatattg cagattatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 51
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cetuximab Q100 VEIK104-107 EC213-214 light chain
      variable domain DNA
      

<400> 51
gacatcttgc tgactcagtc tccagtcatc ctgtctgtga gtccaggaga aagagtcagt 60
ttctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcaaagaaca 120
aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc 180
aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct 240
gaagatattg cagattatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 52
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> HC-Y104D/Q111P control heavy chain nucleic acid
      S119
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<220> 
<221> variation      
<222> 312
<223> n = t or c

<400> 52
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 53
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104D/Q111P control heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 53
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 54
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> DP-h3, 7 heavy chain nucleic acid S119
      
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 54
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 55
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> DP-h3, 7 heavy chain amino acid S119
      
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 55
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 56
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> D-h3, 7 heavy chain nucleic acid S119
      
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<220> 
<221> variation      
<222> 312
<223> n = t or c

<400> 56
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 57
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> D-h3, 7 heavy chain amino acid S119
      
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 57
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 58
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> E-h3, 7 heavy chain nucleic acid S119
      
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 58
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 59
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> E-h3, 7 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 59
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 60
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> E-h3, 7 heavy chain variable domain nucleic acid
      S119
      
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 60
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagctca    357

<210> 61
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> E-h3, 7 heavy chain variable domain amino acid
      S119
      
      

<400> 61
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 62
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> E-h3, 7 heavy chain variable domain nucleic acid
      A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 62
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagcgca    357

<210> 63
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> E-h3, 7 heavy chain variable domain amino acid
      A119
      

<400> 63
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 64
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FDP-h3, 7, 11, 15 heavy chain nucleic acid S119
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 64
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 65
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FDP-h3, 7, 11, 15 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(447)
<223> CH3

<400> 65
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 66
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> HC-Y104D control heavy chain nucleic acid S119
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<220> 
<221> variation      
<222> 312
<223> n = t or c

<400> 66
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 67
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104D control heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 67
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 68
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> HC-Y104D control heavy chain variable domain
      nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = t or c

<400> 68
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagctca    357

<210> 69
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104D control heavy chain variable domain amino
      acid S119
      

<400> 69
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 70
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104D control heavy chain variable domain amino
      acid A119
      

<400> 70
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 71
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> HC-Y104E heavy chain nucleic acid S119
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 71
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 72
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104E heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 72
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 73
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> HC-Y104E heavy chain variable domain nucleic acid
      S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 73
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 60
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 120
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 240
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cagggaacgc tggtcaccgt cagctca    357

<210> 74
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104E heavy chain variable domain amino acid
      S119

<400> 74
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 75
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104E heavy chain variable domain amino acid
      A119
      

<400> 75
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 76
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104E/HC-Q111P heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 76
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 77
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104E/HC-Q111P heavy chain variable domain
      amino acid S119
      

<400> 77
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 78
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-Y104E/HC-Q111P heavy chain variable domain
      amino acid A119
      

<400> 78
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 79
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25C/HC-Y104E heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 79
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Cys Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 80
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25C/HC-Y104E heavy chain variable domain amino
      acid S119
      

<400> 80
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Cys Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 81
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25C/HC-Y104E heavy chain variable domain amino
      acid A119
      

<400> 81
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Cys Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 82
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104E heavy chain amino acid S119
      
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 82
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 83
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104E heavy chain variable domain amino
      acid S119
      

<400> 83
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 84
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104E heavy chain variable domain amino
      acid A119
      

<400> 84
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 85
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104E/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variant domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 85
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 86
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid S119
      

<400> 86
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 87
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid A119
      

<400> 87
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 88
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104E heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 88
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 89
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104E heavy chain variable domain amino
      acid S119
      

<400> 89
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 90
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104E heavy chain variable domain amino
      acid A119
      

<400> 90
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 91
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104E/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 91
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 92
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid S119
      

<400> 92
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 93
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid A119
      

<400> 93
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 94
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104E heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 94
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 95
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104E heavy chain variable
      domain amino acid S119
      

<400> 95
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 96
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104E heavy chain variable
      domain amino acid A119
      

<400> 96
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 97
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 97
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 98
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid S119
      

<400> 98
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 99
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid A119
      

<400> 99
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 100
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104E heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 100
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 101
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104E heavy chain variable domain amino
      acid S119
      

<400> 101
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 102
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104E heavy chain variable domain amino
      acid A119

<400> 102
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 103
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104E/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 103
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 104
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid S119
      

<400> 104
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 105
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid A119
      

<400> 105
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 106
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104E heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 106
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 107
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104E heavy chain variable
      domain amino acid S119
      

<400> 107
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 108
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104E heavy chain variable
      domain amino acid A119
      

<400> 108
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 109
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 109
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 110
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid S119
      

<400> 110
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 111
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid A119
      

<400> 111
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 112
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104E heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 112
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 113
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104E heavy chain variable domain amino
      acid S119
      

<400> 113
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 114
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104E heavy chain variable domain amino
      acid A119
      

<400> 114
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 115
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104E/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 115
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 116
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid S119
      

<400> 116
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 117
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid A119
      

<400> 117
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 118
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104E heavy chain amino acid
      S119
      

<220> 
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 118
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 119
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104E heavy chain variable
      domain amino acid S119
      

<400> 119
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 120
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104E heavy chain variable
      domain amino acid A119
      

<400> 120
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 121
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104E/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 121
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 122
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid S119
      

<400> 122
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 123
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid A119
      

<400> 123
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 124
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-I29S light chain amino acid Q100 VEIK104-107
      EC213-214
      
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 124
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ser Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 125
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-I29S light chain variable domain amino acid
      Q100 VEIK104-107
      

<400> 125
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ser Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 126
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-I29S light chain variable domain amino acid
      A100 LELK104-107
      
      

<400> 126
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ser Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 127
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-I29S light chain variable domain amino acid
      Q100 LELK104-107
      

<400> 127
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ser Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Glu Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 128
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h1, 2, 4, 5, 6, 8 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 128
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 129
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h1, 2, 4, 5, 6, 8 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 129
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 130
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h1, 2, 4, 5, 6, 8 heavy chain variable domain
      nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 130
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 131
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h1, 2, 4, 5, 6, 8 heavy chain variable domain
      amino acid S119
      

<400> 131
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 132
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h1, 2, 4, 5, 6, 8 heavy chain variable domain
      nucleic acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 132
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 133
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h1, 2, 4, 5, 6, 8 heavy chain variable domain
      amino acid A119
      

<400> 133
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 134
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h3, 7 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 134
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 135
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h3, 7 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 135
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 136
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h3, 7 heavy chain variable domain nucleic acid
      S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 136
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 137
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h3, 7 heavy chain variable domain amino acid
      S119
      

<400> 137
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 138
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h3, 7 heavy chain variable domain nucleic acid
      A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 138
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 139
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h3, 7 heavy chain variable domain amino acid
      A119
      

<400> 139
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 140
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h9, 12, 14 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 140
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaatac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 141
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h9, 12, 14 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 141
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 142
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h9, 12, 14 heavy chain variable domain nucleic
      acid S119
      
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 142
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaatac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 143
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h9, 12, 14 heavy chain variable domain amino
      acid S119
      

<400> 143
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 144
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h9, 12, 14 heavy chain variable domain nucleic
      acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 144
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaatac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 145
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h9, 12, 14 heavy chain variable domain amino
      acid A119
      

<400> 145
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 146
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h10, 13 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 146
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaacg ccaagaactc actgtatctg 240
caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 147
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h10, 13 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 147
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 148
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h10, 13 heavy chain variable domain nucleic
      acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 148
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaacg ccaagaactc actgtatctg 240
caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 149
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h10, 13 heavy chain variable domain amino acid
      S119
      

<400> 149
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 150
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h10, 13 heavy chain variable domain nucleic
      acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 150
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaacg ccaagaactc actgtatctg 240
caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 151
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h10, 13 heavy chain variable domain amino acid
      A119
      

<400> 151
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 152
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h1, 3 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 152
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 153
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h1, 3 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 153
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 154
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h1, 3 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 154
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 155
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h1, 3 light chain variable domain amino acid
      Q100 VEIK
      

<400> 155
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 156
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h1, 3 light chain variable domain amino acid
      A100 LELK
      

<400> 156
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 157
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h1, 3 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 157
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 158
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h1, 3 light chain variable domain amino acid
      Q100 LELK
      

<400> 158
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 159
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h2 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 159
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 160
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h2 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 160
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 161
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h2 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 161
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 162
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h2 light chain variable domain amino acid Q100
      VEIK
      

<400> 162
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 163
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h2 light chain variable domain amino acid A100
      LELK
      

<400> 163
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 164
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h2 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 164
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 165
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h2 light chain variable domain amino acid Q100
      LELK
      

<400> 165
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 166
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h4 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)
<223> variable domain

<220> 
<221> C_region       
<222> (322)...(642)
<223> constant domain

<400> 166
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 167
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h4 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 167
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 168
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h4 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 168
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 169
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h4 light chain variable domain amino acid Q100
      VEIK
      

<400> 169
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 170
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h4 light chain variable domain amino acid A100
      LELK
      

<400> 170
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 171
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h4 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 171
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 172
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h4 light chain variable domain amino acid Q100
      LELK
      

<400> 172
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 173
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h5 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)
<223> variable domain

<220> 
<221> C_region       
<222> (322)...(642)
<223> constant domain

<400> 173
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 174
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h5 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 174
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 175
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h5 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 175
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 176
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h5 light chain variable domain amino acid Q100
      VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 176
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 177
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h5 light chain variable domain amino acid A100
      LELK
      

<400> 177
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 178
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h5 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 178
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 179
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h5 light chain variable domain amino acid Q100
      LELK
      

<400> 179
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 180
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h6, 7, 9 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)
<223> variable domain

<220> 
<221> C_region       
<222> (322)...(642)
<223> constant domain

<400> 180
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 181
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h6, 7, 9 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 181
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 182
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h6, 7, 9 light chain variable domain nucleic
      acid Q100 VEIK
      

<400> 182
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 183
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h6, 7, 9 light chain variable domain amino acid
      Q100 VEIK
      

<400> 183
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 184
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h6, 7, 9 light chain variable domain amino acid
      A100 LELK
      

<400> 184
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 185
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h6, 7, 9 light chain variable domain nucleic
      acid Q100 LELK
      

<400> 185
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 186
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h6, 7, 9 light chain variable domain amino acid
      Q100 LELK
      

<400> 186
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 187
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h8 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 187
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagcc 180
aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
gaagattttg cagtttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 188
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h8 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 188
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 189
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h8 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 189
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagcc 180
aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
gaagattttg cagtttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 190
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h8 light chain variable domain amino acid Q100
      VEIK
      

<400> 190
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 191
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h8 light chain variable domain amino acid A100
      LELK
      

<400> 191
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 192
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h8 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 192
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagcc 180
aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
gaagattttg cagtttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 193
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h8 light chain variable domain amino acid Q100
      LELK
      

<400> 193
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 194
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h10, 12 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 194
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 195
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h10, 12 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 195
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 196
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h10, 12 light chain variable domain nucleic
      acid Q100 VEIK
      

<400> 196
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 197
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h10, 12 light chain variable domain amino acid
      Q100 VEIK
      

<400> 197
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 198
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h10, 12 light chain variable domain amino acid
      A100 LELK
      

<400> 198
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 199
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h10, 12 light chain variable domain nucleic
      acid Q100 LELK
      

<400> 199
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 200
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h10, 12 light chain variable domain amino acid
      Q100 LELK
      

<400> 200
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 201
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h13, 14 light chain nucleic acid Q100 VEIK

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 201
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 202
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h13, 14 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 202
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 203
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h13, 14 light chain variable domain nucleic
      acid Q100 VEIK
      

<400> 203
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 204
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h13, 14 light chain variable domain amino acid
      Q100 VEIK
      

<400> 204
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 205
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h13, 14 light chain variable domain amino acid
      A100 LELK
      

<400> 205
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 206
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> EP-h13, 14 light chain variable domain nucleic
      acid Q100 LELK
      

<400> 206
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 207
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> EP-h13, 14 light chain variable domain amino acid
      Q100 LELK
      

<400> 207
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 208
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h1, 19, 20, 21 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 208
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 209
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h1, 19, 20, 21 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 209
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 210
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h1, 19, 20, 21 heavy chain variable domain
      nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 210
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 211
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h1, 19, 20, 21 heavy chain variable domain
      amino acid S119
      

<400> 211
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 212
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h1, 19, 20, 21 heavy chain variable domain
      nucleic acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 212
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 213
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h1, 19, 20, 21 heavy chain variable domain
      amino acid A119
      

<400> 213
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 214
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h2 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (368)...(1347)

<400> 214
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggct 120
cgtggacaac gccttgagtg gataggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 215
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h2 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 215
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 216
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h2 heavy chain variable domain nucleic acid
      S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 216
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggct 120
cgtggacaac gccttgagtg gataggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 217
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h2 heavy chain variable domain amino acid S119
      

<400> 217
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 218
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h2 heavy chain variable domain nucleic acid
      A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 218
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggct 120
cgtggacaac gccttgagtg gataggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 219
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h2 heavy chain variable domain amino acid A119
      

<400> 219
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 220
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h3, 7, 11, 15 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 220
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 221
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h3, 7, 11, 15 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 221
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 222
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h3, 7, 11, 15 heavy chain variable domain
      nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 222
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 223
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h3, 7, 11, 15 heavy chain variable domain
      amino acid S119
      

<400> 223
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 224
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h3, 7, 11, 15 heavy chain variable domain
      nucleic acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 224
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggcc 120
actggacaag ggcttgagtg gatgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 225
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h3, 7, 11, 15 heavy chain variable domain
      amino acid A119
      

<400> 225
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 226
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h4, 8, 12, 16 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 226
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 227
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h4, 8, 12, 16 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 227
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 228
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h4, 8, 12, 16 heavy chain variable domain
      nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 228
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 229
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h4, 8, 12, 16 heavy chain variable domain
      amino acid S119
      

<400> 229
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 230
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h4, 8, 12, 16 heavy chain variable domain
      nucleic acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 230
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 231
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h4, 8, 12, 16 heavy chain variable domain
      amino acid A119
      

<400> 231
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 232
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h5, 9, 13, 17 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 232
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ttcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 233
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h5, 9, 13, 17 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 233
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 234
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h5, 9, 13, 17 heavy chain variable domain
      nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 234
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ttcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 235
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h5, 9, 13, 17 heavy chain variable domain
      amino acid S119
      

<400> 235
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 236
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h5, 9, 13, 17 heavy chain variable domain
      nucleic acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 236
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ttcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 237
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h5, 9, 13, 17 heavy chain variable domain
      amino acid A119
      

<400> 237
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 238
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h6 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 238
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 239
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h6 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 239
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 240
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h6 heavy chain variable domain nucleic acid
      S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 240
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 241
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h6 heavy chain variable domain amino acid S119
      

<400> 241
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 242
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h6 heavy chain variable domain nucleic acid
      A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 242
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 243
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h6 heavy chain variable domain amino acid A119
      

<400> 243
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 244
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h10, 14, 18 heavy chain nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 244
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 245
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h10, 14, 18 heavy chain amino acid S119
      
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 245
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 246
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h10, 14, 18 heavy chain variable domain
      nucleic acid S119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 246
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagctca    357

<210> 247
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h10, 14, 18 heavy chain variable domain amino
      acid S119
      

<400> 247
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 248
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h10, 14, 18 heavy chain variable domain
      nucleic acid A119
      

<220> 
<221> variation      
<222> 312
<223> n = a or g

<400> 248
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg angagtttgc ttactggggc cctggaacgc tggtcaccgt cagcgca    357

<210> 249
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h10, 14, 18 heavy chain variable domain amino
      acid A119
      

<400> 249
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 250
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h1, 2 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 250
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 251
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h1, 2 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 251
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 252
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h1, 2 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 252
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 253
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h1, 2 light chain variable domain amino acid
      Q100 VEIK
      

<400> 253
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 254
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h1, 2 light chain variable domain amino acid
      A100 LELK
      

<400> 254
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 255
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h1, 2 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 255
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 256
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h1, 2 light chain variable domain amino acid
      Q100 LELK
      

<400> 256
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 257
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h3, 4 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 257
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 258
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h3, 4 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 258
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 259
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h3, 4 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 259
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 260
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h3, 4 light chain variable domain amino acid
      Q100 VEIK
      

<400> 260
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 261
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h3, 4 light chain variable domain amino acid
      A100 LELK
      

<400> 261
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 262
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h3, 4 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 262
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 263
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h3, 4 light chain variable domain amino acid
      Q100 LELK
      

<400> 263
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 264
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h5 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 264
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 265
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h5 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 265
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 266
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h5 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 266
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 267
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h5 light chain variable domain amino acid Q100
      VEIK
      

<400> 267
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 268
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h5 light chain variable domain amino acid A100
      LELK
      

<400> 268
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 269
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h5 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 269
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcagaaacca 120
gggaaagctc ctaagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 270
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h5 light chain variable domain amino acid Q100
      LELK
      

<400> 270
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 271
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h6, 7, 8 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 271
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 272
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h6, 7, 8 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 272
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 273
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h6, 7, 8 light chain variable domain nucleic
      acid Q100 VEIK
      

<400> 273
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 274
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h6, 7, 8 light chain variable domain amino
      acid Q100 VEIK
      

<400> 274
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 275
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h6, 7, 8 light chain variable domain amino
      acid A100 LELK
      

<400> 275
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 276
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h6, 7, 8 light chain variable domain nucleic
      acid Q100 LELK
      

<400> 276
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 277
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h6, 7, 8 light chain variable domain amino
      acid Q100 LELK
      

<400> 277
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 278
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h9, 10, 11, 12, 20  light chain nucleic acid
      Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 278
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccacct 180
cgattcagtg gcagcgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 279
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h9, 10, 11, 12, 20  light chain amino acid
      Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 279
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 280
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h9, 10, 11, 12, 20  light chain variable
      domain nucleic acid Q100 VEIK
      

<400> 280
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccacct 180
cgattcagtg gcagcgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 281
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h9, 10, 11, 12, 20  light chain variable
      domain amino acid Q100 VEIK
      

<400> 281
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 282
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h9, 10, 11, 12, 20  light chain variable
      domain amino acid A100 LELK
      

<400> 282
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 283
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h9, 10, 11, 12, 20  light chain variable
      domain nucleic acid Q100 LELK
      

<400> 283
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccacct 180
cgattcagtg gcagcgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 284
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h9, 10, 11, 12, 20  light chain variable
      domain amino acid Q100 LELK
      

<400> 284
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 285
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h13, 14, 15, 16, 21 light chain nucleic acid
      Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 285
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 286
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h13, 14, 15, 16, 21 light chain amino acid
      Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 286
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 287
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h13, 14, 15, 16, 21 light chain variable
      domain nucleic acid Q100 VEIK
      

<400> 287
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 288
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h13, 14, 15, 16, 21 light chain variable
      domain amino acid Q100 VEIK
      

<400> 288
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 289
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h13, 14, 15, 16, 21 light chain variable
      domain amino acid A100 LELK
      

<400> 289
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 290
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h13, 14, 15, 16, 21 light chain variable
      domain nucleic acid Q100 LELK
      

<400> 290
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 291
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h13, 14, 15, 16, 21 light chain variable
      domain amino acid Q100 LELK
      

<400> 291
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 292
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h17 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 292
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagcc 180
aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
gaagattttg cagtttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 293
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h17 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 293
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 294
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h17 light chain variable domain nucleic acid
      Q100 VEIK
      

<400> 294
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagcc 180
aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
gaagattttg cagtttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 295
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h17 light chain variable domain amino acid
      Q100 VEIK
      

<400> 295
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 296
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h17 light chain variable domain amino acid
      A100 LELK
      

<400> 296
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 297
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h17 light chain variable domain nucleic acid
      Q100 LELK
      

<400> 297
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtattggc acaaacatac actggtacca gcagaaacct 120
ggccaggctc ccaggctcct catctattat gcttctgagt ctatctctgg gatcccagcc 180
aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct 240
gaagattttg cagtttatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 298
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h17 light chain variable domain amino acid
      Q100 LELK
      

<400> 298
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 299
<211> 642
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h18, 19 light chain nucleic acid Q100 VEIK
      

<220> 
<221> V_region       
<222> (1)...(321)

<220> 
<221> C_region       
<222> (322)...(642)

<400> 299
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                    642

<210> 300
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h18, 19 light chain amino acid Q100 VEIK
      

<220> 
<221> DOMAIN         
<222> (1)...(107)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (108)...(214)
<223> constant domain

<400> 300
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 301
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h18, 19 light chain variable domain nucleic
      acid Q100 VEIK
      

<400> 301
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 302
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h18, 19 light chain variable domain amino acid
      Q100 VEIK
      

<400> 302
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 303
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h18, 19 light chain variable domain amino acid
      A100 LELK
      

<400> 303
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 304
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> FEP-h18, 19 light chain variable domain nucleic
      acid Q100 LELK
      

<400> 304
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgca gggccagtca gagtattggc acaaacatac actggtacct gcagaagcca 120
gggcagtctc cacagctcct gatctattat gcttctgagt ctatctctgg gatcccagac 180
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240
gaagattttg cagtgtatta ctgtcaacaa aataataact ggccaaccac gttcggccaa 300
gggaccaagc tggagctgaa a                                           321

<210> 305
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> FEP-h18, 19 light chain variable domain amino acid
      Q100 LELK
      

<400> 305
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30          
Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 306
<211> 8345
<212> DNA
<213> Artificial Sequence

<220> 
<223> pcDNA3-Erbitux-LC-IRES-HC-WT
      

<220> 
<221> sig_peptide    
<222> (1126)...(1191)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1192)...(1512)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1513)...(1833)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1876)...(2450)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2464)...(2520)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2521)...(2877)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2878)...(3867)
<223> heavy chain constan domain


<220> 
<221> misc_feature   
<222> (3868)...(3891)
<223> Flag tag

<400> 306
gacggatcgg gagatcttca atattggcca ttagccatat tattcattgg ttatatagca 60
taaatcaata ttggctattg gccattgcat acgttgtatc tatatcataa tatgtacatt 120
tatattggct catgtccaat atgaccgcca tgttggcatt gattattgac tagttattaa 180
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 240
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 300
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 360
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc 420
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 480
cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 540
cggttttggc agtacaccaa ttggcgtgga tagcggtttg actcacgggg atttccaagt 600
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 660
aaatgtcgta acaactgcga tcgcccgccc cgttgacgca aatgggcggt aggcgtgtac 720
ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcact agaagcttta 780
ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac acaacagtct 840
cgaacttaag ctgcagtgac tctcttaagg tagccttgca gaagttggtc gtgaggcact 900
gggcaggtaa gtatcaaggt tacaagacag gtttaaggtg accaatagaa actgggcttg 960
tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac 1020
tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggctagagt 1080
acttaatacg actcactata ggctagtctc gtcgacgaga ctagcatgga catgagggtc 1140
cccgctcagc tcctggggct cctgctgctc tggctcccag gtgccaagtg tgacatcttg 1200
ctgactcagt ctccagtcat cctgtctgtg agtccaggag aaagagtcag tttctcctgc 1260
agggccagtc agagtattgg cacaaacata cactggtatc agcaaagaac aaatggttct 1320
ccaaggcttc tcataaagta tgcttctgag tctatctctg ggatcccttc caggtttagt 1380
ggcagtggat cagggacaga ttttactctt agcatcaaca gtgtggagtc tgaagatatt 1440
gcagattatt actgtcaaca aaataataac tggccaacca cgttcggcca agggaccaag 1500
gtggaaatca aacgtacggt ggctgcacca tctgtcttca tcttcccgcc atctgatgag 1560
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag 1620
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc 1680
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa 1740
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg 1800
cccgtcacaa agagcttcaa caggggagag tgttgactcg aggcgcgccg agcatgcatc 1860
tagggcggcc aattccgccc ctctcccccc ccccccctaa cgttactggc cgaagccgct 1920
tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg 1980
gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt 2040
cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg 2100
aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac 2160
ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg 2220
cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct 2280
caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg 2340
atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag 2400
gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca 2460
accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgt 2520
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 2580
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 2640
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 2700
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 2760
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 2820
tactatgatt acgagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 2880
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 2940
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 3000
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 3060
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 3120
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 3180
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 3240
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 3300
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 3360
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 3420
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 3480
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 3540
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 3600
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 3660
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 3720
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 3780
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 3840
aagagcctct ccctgtctcc gggtaaagat tacaaggatg acgacgataa gtgagcggcc 3900
gctcgagtct agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg 3960
ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc 4020
cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc 4080
tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag 4140
gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc 4200
tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac 4260
gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc 4320
ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt 4380
agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg 4440
ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac 4500
gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta 4560
ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat 4620
ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag 4680
tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc 4740
aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat 4800
tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 4860
tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 4920
gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt 4980
tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcaaga gacaggatga 5040
ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg 5100
gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg 5160
ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc 5220
ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct 5280
tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa 5340
gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg 5400
gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa 5460
gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat 5520
gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg 5580
cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc 5640
atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac 5700
cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg 5760
gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc 5820
tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag 5880
cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg 5940
gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc 6000
tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca 6060
atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 6120
ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg 6180
cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca 6240
acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca 6300
cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc 6360
attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt 6420
cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact 6480
caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag 6540
caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata 6600
ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc 6660
cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg 6720
ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc 6780
tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg 6840
gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc 6900
ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga 6960
ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg 7020
gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa 7080
aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ttttttgttt 7140
gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta 7200
cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat 7260
caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa 7320
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct 7380
cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta 7440
cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct 7500
caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg 7560
gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa 7620
gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt 7680
cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta 7740
catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca 7800
gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta 7860
ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct 7920
gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg 7980
cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac 8040
tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact 8100
gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa 8160
atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt 8220
ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat 8280
gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg 8340
acgtc                                                             8345



<210> 307
<211> 8345
<212> DNA
<213> Artificial Sequence

<220> 
<223> pcDNA3-Erbitux-LC-IRES-HC-Y104D(GAT)
      

<220> 
<221> sig_peptide    
<222> (1126)...(1191)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1192)...(1512)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1513)...(1833)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1876)...(2450)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2464)...(2520)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2521)...(2877)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2878)...(3867)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3868)...(3891)
<223> Flag tag

<400> 307
gacggatcgg gagatcttca atattggcca ttagccatat tattcattgg ttatatagca 60
taaatcaata ttggctattg gccattgcat acgttgtatc tatatcataa tatgtacatt 120
tatattggct catgtccaat atgaccgcca tgttggcatt gattattgac tagttattaa 180
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 240
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 300
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 360
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc 420
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 480
cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 540
cggttttggc agtacaccaa ttggcgtgga tagcggtttg actcacgggg atttccaagt 600
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 660
aaatgtcgta acaactgcga tcgcccgccc cgttgacgca aatgggcggt aggcgtgtac 720
ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcact agaagcttta 780
ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac acaacagtct 840
cgaacttaag ctgcagtgac tctcttaagg tagccttgca gaagttggtc gtgaggcact 900
gggcaggtaa gtatcaaggt tacaagacag gtttaaggtg accaatagaa actgggcttg 960
tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac 1020
tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggctagagt 1080
acttaatacg actcactata ggctagtctc gtcgacgaga ctagcatgga catgagggtc 1140
cccgctcagc tcctggggct cctgctgctc tggctcccag gtgccaagtg tgacatcttg 1200
ctgactcagt ctccagtcat cctgtctgtg agtccaggag aaagagtcag tttctcctgc 1260
agggccagtc agagtattgg cacaaacata cactggtatc agcaaagaac aaatggttct 1320
ccaaggcttc tcataaagta tgcttctgag tctatctctg ggatcccttc caggtttagt 1380
ggcagtggat cagggacaga ttttactctt agcatcaaca gtgtggagtc tgaagatatt 1440
gcagattatt actgtcaaca aaataataac tggccaacca cgttcggcca agggaccaag 1500
gtggaaatca aacgtacggt ggctgcacca tctgtcttca tcttcccgcc atctgatgag 1560
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag 1620
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc 1680
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa 1740
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg 1800
cccgtcacaa agagcttcaa caggggagag tgttgactcg aggcgcgccg agcatgcatc 1860
tagggcggcc aattccgccc ctctcccccc ccccccctaa cgttactggc cgaagccgct 1920
tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg 1980
gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt 2040
cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg 2100
aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac 2160
ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg 2220
cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct 2280
caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg 2340
atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag 2400
gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca 2460
accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgt 2520
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 2580
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 2640
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 2700
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 2760
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 2820
tactatgatg atgagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 2880
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 2940
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 3000
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 3060
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 3120
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 3180
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 3240
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 3300
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 3360
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 3420
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 3480
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 3540
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 3600
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 3660
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 3720
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 3780
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 3840
aagagcctct ccctgtctcc gggtaaagat tacaaggatg acgacgataa gtgagcggcc 3900
gctcgagtct agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg 3960
ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc 4020
cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc 4080
tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag 4140
gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc 4200
tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac 4260
gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc 4320
ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt 4380
agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg 4440
ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac 4500
gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta 4560
ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat 4620
ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag 4680
tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc 4740
aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat 4800
tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 4860
tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 4920
gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt 4980
tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcaaga gacaggatga 5040
ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg 5100
gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg 5160
ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc 5220
ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct 5280
tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa 5340
gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg 5400
gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa 5460
gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat 5520
gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg 5580
cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc 5640
atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac 5700
cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg 5760
gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc 5820
tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag 5880
cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg 5940
gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc 6000
tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca 6060
atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 6120
ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg 6180
cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca 6240
acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca 6300
cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc 6360
attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt 6420
cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact 6480
caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag 6540
caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata 6600
ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc 6660
cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg 6720
ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc 6780
tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg 6840
gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc 6900
ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga 6960
ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg 7020
gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa 7080
aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ttttttgttt 7140
gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta 7200
cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat 7260
caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa 7320
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct 7380
cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta 7440
cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct 7500
caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg 7560
gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa 7620
gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt 7680
cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta 7740
catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca 7800
gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta 7860
ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct 7920
gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg 7980
cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac 8040
tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact 8100
gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa 8160
atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt 8220
ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat 8280
gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg 8340
acgtc                                                             8345



<210> 308
<211> 8345
<212> DNA
<213> Artificial Sequence

<220> 
<223> pcDNA3-Erbitux-LC-IRES-HC-Y104D(GAC)
      

<220> 
<221> sig_peptide    
<222> (1126)...(1191)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1192)...(1512)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1513)...(1833)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1876)...(2450)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2464)...(2520)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2521)...(2877)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2878)...(3867)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3868)...(3891)
<223> Flag tag

<400> 308
gacggatcgg gagatcttca atattggcca ttagccatat tattcattgg ttatatagca 60
taaatcaata ttggctattg gccattgcat acgttgtatc tatatcataa tatgtacatt 120
tatattggct catgtccaat atgaccgcca tgttggcatt gattattgac tagttattaa 180
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 240
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 300
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 360
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc 420
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 480
cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 540
cggttttggc agtacaccaa ttggcgtgga tagcggtttg actcacgggg atttccaagt 600
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 660
aaatgtcgta acaactgcga tcgcccgccc cgttgacgca aatgggcggt aggcgtgtac 720
ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcact agaagcttta 780
ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac acaacagtct 840
cgaacttaag ctgcagtgac tctcttaagg tagccttgca gaagttggtc gtgaggcact 900
gggcaggtaa gtatcaaggt tacaagacag gtttaaggtg accaatagaa actgggcttg 960
tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac 1020
tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggctagagt 1080
acttaatacg actcactata ggctagtctc gtcgacgaga ctagcatgga catgagggtc 1140
cccgctcagc tcctggggct cctgctgctc tggctcccag gtgccaagtg tgacatcttg 1200
ctgactcagt ctccagtcat cctgtctgtg agtccaggag aaagagtcag tttctcctgc 1260
agggccagtc agagtattgg cacaaacata cactggtatc agcaaagaac aaatggttct 1320
ccaaggcttc tcataaagta tgcttctgag tctatctctg ggatcccttc caggtttagt 1380
ggcagtggat cagggacaga ttttactctt agcatcaaca gtgtggagtc tgaagatatt 1440
gcagattatt actgtcaaca aaataataac tggccaacca cgttcggcca agggaccaag 1500
gtggaaatca aacgtacggt ggctgcacca tctgtcttca tcttcccgcc atctgatgag 1560
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag 1620
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc 1680
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa 1740
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg 1800
cccgtcacaa agagcttcaa caggggagag tgttgactcg aggcgcgccg agcatgcatc 1860
tagggcggcc aattccgccc ctctcccccc ccccccctaa cgttactggc cgaagccgct 1920
tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg 1980
gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt 2040
cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg 2100
aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac 2160
ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg 2220
cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct 2280
caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg 2340
atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag 2400
gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca 2460
accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgt 2520
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 2580
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 2640
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 2700
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 2760
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 2820
tactatgatg acgagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 2880
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 2940
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 3000
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 3060
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 3120
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 3180
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 3240
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 3300
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 3360
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 3420
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 3480
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 3540
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 3600
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 3660
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 3720
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 3780
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 3840
aagagcctct ccctgtctcc gggtaaagat tacaaggatg acgacgataa gtgagcggcc 3900
gctcgagtct agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg 3960
ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc 4020
cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc 4080
tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag 4140
gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc 4200
tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac 4260
gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc 4320
ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt 4380
agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg 4440
ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac 4500
gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta 4560
ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat 4620
ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag 4680
tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc 4740
aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat 4800
tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 4860
tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 4920
gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt 4980
tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcaaga gacaggatga 5040
ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg 5100
gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg 5160
ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc 5220
ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct 5280
tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa 5340
gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg 5400
gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa 5460
gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat 5520
gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg 5580
cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc 5640
atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac 5700
cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg 5760
gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc 5820
tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag 5880
cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg 5940
gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc 6000
tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca 6060
atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 6120
ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg 6180
cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca 6240
acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca 6300
cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc 6360
attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt 6420
cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact 6480
caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag 6540
caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata 6600
ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc 6660
cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg 6720
ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc 6780
tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg 6840
gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc 6900
ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga 6960
ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg 7020
gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa 7080
aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ttttttgttt 7140
gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta 7200
cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat 7260
caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa 7320
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct 7380
cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta 7440
cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct 7500
caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg 7560
gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa 7620
gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt 7680
cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta 7740
catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca 7800
gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta 7860
ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct 7920
gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg 7980
cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac 8040
tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact 8100
gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa 8160
atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt 8220
ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat 8280
gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg 8340
acgtc                                                             8345



<210> 309
<211> 8345
<212> DNA
<213> Artificial Sequence

<220> 
<223> pcDNA3-Erbitux-LC-IRES-HC-Y104E(GAA)
      

<220> 
<221> sig_peptide    
<222> (1126)...(1191)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1192)...(1512)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1513)...(1833)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1876)...(2450)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2464)...(2520)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2521)...(2877)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2878)...(3867)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3868)...(3891)
<223> Flag tag

<400> 309
gacggatcgg gagatcttca atattggcca ttagccatat tattcattgg ttatatagca 60
taaatcaata ttggctattg gccattgcat acgttgtatc tatatcataa tatgtacatt 120
tatattggct catgtccaat atgaccgcca tgttggcatt gattattgac tagttattaa 180
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 240
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 300
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 360
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc 420
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 480
cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 540
cggttttggc agtacaccaa ttggcgtgga tagcggtttg actcacgggg atttccaagt 600
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 660
aaatgtcgta acaactgcga tcgcccgccc cgttgacgca aatgggcggt aggcgtgtac 720
ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcact agaagcttta 780
ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac acaacagtct 840
cgaacttaag ctgcagtgac tctcttaagg tagccttgca gaagttggtc gtgaggcact 900
gggcaggtaa gtatcaaggt tacaagacag gtttaaggtg accaatagaa actgggcttg 960
tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac 1020
tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggctagagt 1080
acttaatacg actcactata ggctagtctc gtcgacgaga ctagcatgga catgagggtc 1140
cccgctcagc tcctggggct cctgctgctc tggctcccag gtgccaagtg tgacatcttg 1200
ctgactcagt ctccagtcat cctgtctgtg agtccaggag aaagagtcag tttctcctgc 1260
agggccagtc agagtattgg cacaaacata cactggtatc agcaaagaac aaatggttct 1320
ccaaggcttc tcataaagta tgcttctgag tctatctctg ggatcccttc caggtttagt 1380
ggcagtggat cagggacaga ttttactctt agcatcaaca gtgtggagtc tgaagatatt 1440
gcagattatt actgtcaaca aaataataac tggccaacca cgttcggcca agggaccaag 1500
gtggaaatca aacgtacggt ggctgcacca tctgtcttca tcttcccgcc atctgatgag 1560
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag 1620
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc 1680
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa 1740
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg 1800
cccgtcacaa agagcttcaa caggggagag tgttgactcg aggcgcgccg agcatgcatc 1860
tagggcggcc aattccgccc ctctcccccc ccccccctaa cgttactggc cgaagccgct 1920
tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg 1980
gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt 2040
cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg 2100
aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac 2160
ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg 2220
cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct 2280
caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg 2340
atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag 2400
gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca 2460
accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgt 2520
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 2580
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 2640
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 2700
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 2760
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 2820
tactatgatg aagagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 2880
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 2940
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 3000
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 3060
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 3120
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 3180
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 3240
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 3300
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 3360
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 3420
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 3480
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 3540
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 3600
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 3660
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 3720
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 3780
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 3840
aagagcctct ccctgtctcc gggtaaagat tacaaggatg acgacgataa gtgagcggcc 3900
gctcgagtct agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg 3960
ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc 4020
cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc 4080
tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag 4140
gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc 4200
tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac 4260
gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc 4320
ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt 4380
agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg 4440
ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac 4500
gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta 4560
ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat 4620
ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag 4680
tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc 4740
aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat 4800
tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 4860
tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 4920
gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt 4980
tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcaaga gacaggatga 5040
ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg 5100
gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg 5160
ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc 5220
ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct 5280
tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa 5340
gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg 5400
gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa 5460
gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat 5520
gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg 5580
cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc 5640
atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac 5700
cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg 5760
gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc 5820
tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag 5880
cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg 5940
gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc 6000
tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca 6060
atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 6120
ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg 6180
cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca 6240
acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca 6300
cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc 6360
attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt 6420
cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact 6480
caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag 6540
caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata 6600
ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc 6660
cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg 6720
ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc 6780
tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg 6840
gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc 6900
ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga 6960
ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg 7020
gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa 7080
aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ttttttgttt 7140
gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta 7200
cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat 7260
caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa 7320
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct 7380
cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta 7440
cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct 7500
caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg 7560
gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa 7620
gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt 7680
cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta 7740
catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca 7800
gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta 7860
ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct 7920
gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg 7980
cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac 8040
tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact 8100
gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa 8160
atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt 8220
ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat 8280
gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg 8340
acgtc                                                             8345



<210> 310
<211> 8345
<212> DNA
<213> Artificial Sequence

<220> 
<223> pcDNA3-Erbitux-LC-IRES-HC-Y104E(GAG)
      

<220> 
<221> sig_peptide    
<222> (1126)...(1191)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1192)...(1512)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1513)...(1833)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1876)...(2450)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2464)...(2520)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2521)...(2877)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2878)...(3867)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3868)...(3891)
<223> Flag tag

<400> 310
gacggatcgg gagatcttca atattggcca ttagccatat tattcattgg ttatatagca 60
taaatcaata ttggctattg gccattgcat acgttgtatc tatatcataa tatgtacatt 120
tatattggct catgtccaat atgaccgcca tgttggcatt gattattgac tagttattaa 180
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 240
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 300
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 360
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc 420
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 480
cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 540
cggttttggc agtacaccaa ttggcgtgga tagcggtttg actcacgggg atttccaagt 600
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 660
aaatgtcgta acaactgcga tcgcccgccc cgttgacgca aatgggcggt aggcgtgtac 720
ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcact agaagcttta 780
ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac acaacagtct 840
cgaacttaag ctgcagtgac tctcttaagg tagccttgca gaagttggtc gtgaggcact 900
gggcaggtaa gtatcaaggt tacaagacag gtttaaggtg accaatagaa actgggcttg 960
tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac 1020
tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggctagagt 1080
acttaatacg actcactata ggctagtctc gtcgacgaga ctagcatgga catgagggtc 1140
cccgctcagc tcctggggct cctgctgctc tggctcccag gtgccaagtg tgacatcttg 1200
ctgactcagt ctccagtcat cctgtctgtg agtccaggag aaagagtcag tttctcctgc 1260
agggccagtc agagtattgg cacaaacata cactggtatc agcaaagaac aaatggttct 1320
ccaaggcttc tcataaagta tgcttctgag tctatctctg ggatcccttc caggtttagt 1380
ggcagtggat cagggacaga ttttactctt agcatcaaca gtgtggagtc tgaagatatt 1440
gcagattatt actgtcaaca aaataataac tggccaacca cgttcggcca agggaccaag 1500
gtggaaatca aacgtacggt ggctgcacca tctgtcttca tcttcccgcc atctgatgag 1560
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag 1620
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc 1680
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa 1740
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg 1800
cccgtcacaa agagcttcaa caggggagag tgttgactcg aggcgcgccg agcatgcatc 1860
tagggcggcc aattccgccc ctctcccccc ccccccctaa cgttactggc cgaagccgct 1920
tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg 1980
gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt 2040
cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg 2100
aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac 2160
ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg 2220
cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct 2280
caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg 2340
atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag 2400
gccccccgaa ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca 2460
accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgt 2520
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc 2580
acctgcacag tctctggttt ctcattaact aactatggtg tacactgggt tcgccagtct 2640
ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaaacac agactataat 2700
acacctttca catccagact gagcatcaac aaggacaatt ccaagagcca agttttcttt 2760
aaaatgaaca gtctgcaatc taatgacaca gccatatatt actgtgccag agccctcacc 2820
tactatgatg aggagtttgc ttactggggc cagggaacgc tggtcaccgt cagctcagcc 2880
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 2940
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 3000
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 3060
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 3120
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 3180
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 3240
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 3300
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 3360
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 3420
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 3480
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 3540
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 3600
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 3660
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 3720
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 3780
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 3840
aagagcctct ccctgtctcc gggtaaagat tacaaggatg acgacgataa gtgagcggcc 3900
gctcgagtct agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg 3960
ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc 4020
cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc 4080
tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag 4140
gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc 4200
tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac 4260
gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc 4320
ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt 4380
agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg 4440
ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac 4500
gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta 4560
ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat 4620
ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag 4680
tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc 4740
aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat 4800
tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt 4860
tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc 4920
gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt 4980
tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcaaga gacaggatga 5040
ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg 5100
gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg 5160
ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc 5220
ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct 5280
tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa 5340
gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg 5400
gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa 5460
gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat 5520
gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg 5580
cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc 5640
atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac 5700
cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg 5760
gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc 5820
tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag 5880
cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg 5940
gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc 6000
tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca 6060
atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt 6120
ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg 6180
cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca 6240
acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca 6300
cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc 6360
attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt 6420
cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact 6480
caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag 6540
caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata 6600
ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc 6660
cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg 6720
ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc 6780
tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg 6840
gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc 6900
ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga 6960
ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg 7020
gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa 7080
aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ttttttgttt 7140
gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta 7200
cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat 7260
caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa 7320
gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct 7380
cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta 7440
cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct 7500
caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg 7560
gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa 7620
gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt 7680
cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta 7740
catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca 7800
gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta 7860
ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct 7920
gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg 7980
cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac 8040
tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact 8100
gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa 8160
atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt 8220
ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat 8280
gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg 8340
acgtc                                                             8345



<210> 311
<211> 8220
<212> DNA
<213> Artificial Sequence

<220> 
<223> pDP-h7
      

<220> 
<221> sig_peptide    
<222> (1109)...(1174)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1175)...(1495)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1496)...(1816)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1859)...(2433)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2447)...(2503)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2504)...(2860)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2861)...(3850)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3851)...(3874)
<223> Flag tag

<400> 311
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caattggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg 660
cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata 720
agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac 780
agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt 840
gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 900
ggttacaaga caggtttaag gtgaccaata gaaactgggc ttgtcgagac agagaagact 960
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 1020
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1080
ataggctagt ctcgtcgacg agactagcat ggacatgagg gtccccgctc agctcctggg 1140
gctcctgctg ctctggctcc caggtgccaa gtgtgccatc cagttgaccc agtctccatc 1200
ctccctgtct gcatctgtag gagacagagt caccatcact tgcagggcca gtcagagtat 1260
tggcacaaac atacactggt acctgcagaa gccagggcag tctccacagc tcctgatcta 1320
ttatgcttct gagtctatct ctgggatccc agacaggttc agtggcagtg ggtctgggac 1380
agacttcact ctcaccatca gcagactgga gcctgaagat tttgcagtgt attactgtca 1440
acaaaataat aactggccaa ccacgttcgg ccaagggacc aaggtggaaa tcaaacgtac 1500
ggtggctgca ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac 1560
tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa 1620
ggtggataac gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa 1680
ggacagcacc tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca 1740
caaagtctac gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt 1800
caacagggga gagtgttgac tcgaggcgcg ccgagcatgc atctagggcg gccaattccg 1860
cccctctccc cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt 1920
gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg 1980
aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga 2040
atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa 2100
acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc 2160
tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac 2220
gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag 2280
gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc 2340
acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg 2400
gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccatgg agtttgggct 2460
gagctggctt tttcttgtgg ctattttaaa aggtgtccag tgtgaggtcc agctggtaca 2520
gtctggggct gaggtgaaga agcctggggc tacagtgaaa atctcctgca aggtttctgg 2580
tttctcatta actaactatg gtgtacactg ggtgcgacag gccactggac aagggcttga 2640
gtggatgggt gtgatatgga gtggtggaaa cacagactat aatacacctt tcacatccag 2700
attcaccatc tccagagatg attcaaagaa cacggcgtat ctgcaaatga acagcctgaa 2760
aaccgaggac acggccgtgt attactgtgc cagagccctc acctactatg atgatgagtt 2820
tgcttactgg ggccctggaa cgctggtcac cgtcagctca gcctccacca agggcccatc 2880
ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg 2940
cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac 3000
cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag 3060
cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca 3120
caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca 3180
cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc 3240
cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt 3300
ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt 3360
gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag 3420
cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtcag 3480
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg 3540
agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag 3600
cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa 3660
tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt 3720
cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc 3780
atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc 3840
tccgggtaaa gattacaagg atgacgacga taagtgagcg gccgcttccc tttagtgagg 3900
gttaatgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag 3960
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 4020
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 4080
tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat 4140
ccgataagga tcgatccggg ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc 4200
caacagttgc gcagcctgaa tggcgaatgg acgcgccctg tagcggcgca ttaagcgcgg 4260
cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4320
ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4380
atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4440
ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4500
tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4560
accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4620
taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4680
caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg 4740
cggatctgcg cagcaccatg gcctgaaata acctctgaaa gaggaacttg gttaggtacc 4800
ttctgaggcg gaaagaacca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca 4860
ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt 4920
ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca 4980
gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc 5040
cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg 5100
gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa 5160
aagcttgatt cttctgacac aacagtctcg aacttaaggc tagagccacc atgattgaac 5220
aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact 5280
gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc 5340
gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg 5400
cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg 5460
tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt 5520
catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc 5580
atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag 5640
cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg 5700
ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc 5760
tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt 5820
ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg 5880
ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt 5940
acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct 6000
tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg 6060
atggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat 6120
cgatagcgat aaggatccgc gtatggtgca ctctcagtac aatctgctct gatgccgcat 6180
agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc 6240
tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt 6300
tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc ctatttttat 6360
aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt cggggaaatg 6420
tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga 6480
gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac 6540
atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc 6600
cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca 6660
tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc 6720
caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg 6780
ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac 6840
cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca 6900
taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg 6960
agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac 7020
cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg 7080
caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat 7140
taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg 7200
ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg 7260
cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc 7320
aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc 7380
attggtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 7440
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 7500
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 7560
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 7620
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 7680
gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca 7740
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 7800
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 7860
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 7920
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 7980
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 8040
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 8100
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 8160
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatggct cgacagatct 8220




<210> 312
<211> 8220
<212> DNA
<213> Artificial Sequence

<220> 
<223> pD-h7
      

<220> 
<221> sig_peptide    
<222> (1109)...(1174)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1175)...(1495)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1496)...(1816)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1859)...(2433)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2447)...(2503)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2504)...(2860)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2861)...(3850)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3851)...(3874)
<223> Flag tag

<400> 312
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caattggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg 660
cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata 720
agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac 780
agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt 840
gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 900
ggttacaaga caggtttaag gtgaccaata gaaactgggc ttgtcgagac agagaagact 960
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 1020
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1080
ataggctagt ctcgtcgacg agactagcat ggacatgagg gtccccgctc agctcctggg 1140
gctcctgctg ctctggctcc caggtgccaa gtgtgccatc cagttgaccc agtctccatc 1200
ctccctgtct gcatctgtag gagacagagt caccatcact tgcagggcca gtcagagtat 1260
tggcacaaac atacactggt acctgcagaa gccagggcag tctccacagc tcctgatcta 1320
ttatgcttct gagtctatct ctgggatccc agacaggttc agtggcagtg ggtctgggac 1380
agacttcact ctcaccatca gcagactgga gcctgaagat tttgcagtgt attactgtca 1440
acaaaataat aactggccaa ccacgttcgg ccaagggacc aaggtggaaa tcaaacgtac 1500
ggtggctgca ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac 1560
tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa 1620
ggtggataac gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa 1680
ggacagcacc tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca 1740
caaagtctac gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt 1800
caacagggga gagtgttgac tcgaggcgcg ccgagcatgc atctagggcg gccaattccg 1860
cccctctccc cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt 1920
gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg 1980
aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga 2040
atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa 2100
acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc 2160
tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac 2220
gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag 2280
gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc 2340
acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg 2400
gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccatgg agtttgggct 2460
gagctggctt tttcttgtgg ctattttaaa aggtgtccag tgtgaggtcc agctggtaca 2520
gtctggggct gaggtgaaga agcctggggc tacagtgaaa atctcctgca aggtttctgg 2580
tttctcatta actaactatg gtgtacactg ggtgcgacag gccactggac aagggcttga 2640
gtggatgggt gtgatatgga gtggtggaaa cacagactat aatacacctt tcacatccag 2700
attcaccatc tccagagatg attcaaagaa cacggcgtat ctgcaaatga acagcctgaa 2760
aaccgaggac acggccgtgt attactgtgc cagagccctc acctactatg atgatgagtt 2820
tgcttactgg ggccagggaa cgctggtcac cgtcagctca gcctccacca agggcccatc 2880
ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg 2940
cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac 3000
cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag 3060
cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca 3120
caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca 3180
cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc 3240
cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt 3300
ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt 3360
gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag 3420
cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtcag 3480
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg 3540
agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag 3600
cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa 3660
tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt 3720
cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc 3780
atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc 3840
tccgggtaaa gattacaagg atgacgacga taagtgagcg gccgcttccc tttagtgagg 3900
gttaatgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag 3960
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 4020
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 4080
tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat 4140
ccgataagga tcgatccggg ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc 4200
caacagttgc gcagcctgaa tggcgaatgg acgcgccctg tagcggcgca ttaagcgcgg 4260
cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4320
ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4380
atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4440
ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4500
tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4560
accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4620
taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4680
caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg 4740
cggatctgcg cagcaccatg gcctgaaata acctctgaaa gaggaacttg gttaggtacc 4800
ttctgaggcg gaaagaacca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca 4860
ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt 4920
ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca 4980
gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc 5040
cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg 5100
gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa 5160
aagcttgatt cttctgacac aacagtctcg aacttaaggc tagagccacc atgattgaac 5220
aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact 5280
gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc 5340
gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg 5400
cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg 5460
tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt 5520
catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc 5580
atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag 5640
cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg 5700
ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc 5760
tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt 5820
ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg 5880
ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt 5940
acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct 6000
tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg 6060
atggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat 6120
cgatagcgat aaggatccgc gtatggtgca ctctcagtac aatctgctct gatgccgcat 6180
agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc 6240
tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt 6300
tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc ctatttttat 6360
aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt cggggaaatg 6420
tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga 6480
gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac 6540
atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc 6600
cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca 6660
tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc 6720
caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg 6780
ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac 6840
cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca 6900
taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg 6960
agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac 7020
cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg 7080
caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat 7140
taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg 7200
ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg 7260
cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc 7320
aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc 7380
attggtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 7440
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 7500
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 7560
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 7620
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 7680
gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca 7740
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 7800
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 7860
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 7920
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 7980
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 8040
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 8100
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 8160
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatggct cgacagatct 8220




<210> 313
<211> 8220
<212> DNA
<213> Artificial Sequence

<220> 
<223> pE-h7

<220> 
<221> sig_peptide    
<222> (1109)...(1174)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1175)...(1495)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1496)...(1816)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1859)...(2433)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2447)...(2503)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2504)...(2860)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2861)...(3850)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3851)...(3874)
<223> Flag tag

<400> 313
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caattggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg 660
cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata 720
agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac 780
agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt 840
gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 900
ggttacaaga caggtttaag gtgaccaata gaaactgggc ttgtcgagac agagaagact 960
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 1020
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1080
ataggctagt ctcgtcgacg agactagcat ggacatgagg gtccccgctc agctcctggg 1140
gctcctgctg ctctggctcc caggtgccaa gtgtgccatc cagttgaccc agtctccatc 1200
ctccctgtct gcatctgtag gagacagagt caccatcact tgcagggcca gtcagagtat 1260
tggcacaaac atacactggt acctgcagaa gccagggcag tctccacagc tcctgatcta 1320
ttatgcttct gagtctatct ctgggatccc agacaggttc agtggcagtg ggtctgggac 1380
agacttcact ctcaccatca gcagactgga gcctgaagat tttgcagtgt attactgtca 1440
acaaaataat aactggccaa ccacgttcgg ccaagggacc aaggtggaaa tcaaacgtac 1500
ggtggctgca ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac 1560
tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa 1620
ggtggataac gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa 1680
ggacagcacc tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca 1740
caaagtctac gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt 1800
caacagggga gagtgttgac tcgaggcgcg ccgagcatgc atctagggcg gccaattccg 1860
cccctctccc cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt 1920
gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg 1980
aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga 2040
atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa 2100
acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc 2160
tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac 2220
gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag 2280
gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc 2340
acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg 2400
gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccatgg agtttgggct 2460
gagctggctt tttcttgtgg ctattttaaa aggtgtccag tgtgaggtcc agctggtaca 2520
gtctggggct gaggtgaaga agcctggggc tacagtgaaa atctcctgca aggtttctgg 2580
tttctcatta actaactatg gtgtacactg ggtgcgacag gccactggac aagggcttga 2640
gtggatgggt gtgatatgga gtggtggaaa cacagactat aatacacctt tcacatccag 2700
attcaccatc tccagagatg attcaaagaa cacggcgtat ctgcaaatga acagcctgaa 2760
aaccgaggac acggccgtgt attactgtgc cagagccctc acctactatg atgaggagtt 2820
tgcttactgg ggccagggaa cgctggtcac cgtcagctca gcctccacca agggcccatc 2880
ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg 2940
cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac 3000
cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag 3060
cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca 3120
caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca 3180
cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc 3240
cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt 3300
ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt 3360
gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag 3420
cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtcag 3480
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg 3540
agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag 3600
cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa 3660
tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt 3720
cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc 3780
atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc 3840
tccgggtaaa gattacaagg atgacgacga taagtgagcg gccgcttccc tttagtgagg 3900
gttaatgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag 3960
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 4020
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 4080
tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat 4140
ccgataagga tcgatccggg ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc 4200
caacagttgc gcagcctgaa tggcgaatgg acgcgccctg tagcggcgca ttaagcgcgg 4260
cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4320
ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4380
atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4440
ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4500
tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4560
accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4620
taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4680
caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg 4740
cggatctgcg cagcaccatg gcctgaaata acctctgaaa gaggaacttg gttaggtacc 4800
ttctgaggcg gaaagaacca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca 4860
ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt 4920
ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca 4980
gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc 5040
cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg 5100
gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa 5160
aagcttgatt cttctgacac aacagtctcg aacttaaggc tagagccacc atgattgaac 5220
aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact 5280
gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc 5340
gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg 5400
cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg 5460
tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt 5520
catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc 5580
atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag 5640
cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg 5700
ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc 5760
tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt 5820
ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg 5880
ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt 5940
acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct 6000
tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg 6060
atggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat 6120
cgatagcgat aaggatccgc gtatggtgca ctctcagtac aatctgctct gatgccgcat 6180
agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc 6240
tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt 6300
tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc ctatttttat 6360
aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt cggggaaatg 6420
tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga 6480
gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac 6540
atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc 6600
cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca 6660
tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc 6720
caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg 6780
ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac 6840
cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca 6900
taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg 6960
agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac 7020
cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg 7080
caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat 7140
taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg 7200
ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg 7260
cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc 7320
aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc 7380
attggtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 7440
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 7500
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 7560
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 7620
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 7680
gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca 7740
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 7800
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 7860
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 7920
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 7980
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 8040
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 8100
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 8160
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatggct cgacagatct 8220




<210> 314
<211> 8220
<212> DNA
<213> Artificial Sequence

<220> 
<223> pEP-h7
      

<220> 
<221> sig_peptide    
<222> (1109)...(1174)
<223> light chain signal sequence

<220> 
<221> V_region       
<222> (1175)...(1495)
<223> light chain variable domain

<220> 
<221> C_region       
<222> (1496)...(1816)
<223> light chain constant domain

<220> 
<221> RBS            
<222> (1859)...(2433)
<223> IRES


<220> 
<221> sig_peptide    
<222> (2447)...(2503)
<223> heavy chain signal sequence


<220> 
<221> V_region       
<222> (2504)...(2860)
<223> heavy chain variable domain


<220> 
<221> C_region       
<222> (2861)...(3850)
<223> heavy chain constant domain


<220> 
<221> misc_feature   
<222> (3851)...(3874)
<223> Flag tag

<400> 314
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caattggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactg 660
cgatcgcccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata 720
agcagagctc gtttagtgaa ccgtcagatc actagaagct ttattgcggt agtttatcac 780
agttaaattg ctaacgcagt cagtgcttct gacacaacag tctcgaactt aagctgcagt 840
gactctctta aggtagcctt gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 900
ggttacaaga caggtttaag gtgaccaata gaaactgggc ttgtcgagac agagaagact 960
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 1020
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1080
ataggctagt ctcgtcgacg agactagcat ggacatgagg gtccccgctc agctcctggg 1140
gctcctgctg ctctggctcc caggtgccaa gtgtgccatc cagttgaccc agtctccatc 1200
ctccctgtct gcatctgtag gagacagagt caccatcact tgcagggcca gtcagagtat 1260
tggcacaaac atacactggt acctgcagaa gccagggcag tctccacagc tcctgatcta 1320
ttatgcttct gagtctatct ctgggatccc agacaggttc agtggcagtg ggtctgggac 1380
agacttcact ctcaccatca gcagactgga gcctgaagat tttgcagtgt attactgtca 1440
acaaaataat aactggccaa ccacgttcgg ccaagggacc aaggtggaaa tcaaacgtac 1500
ggtggctgca ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac 1560
tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa 1620
ggtggataac gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa 1680
ggacagcacc tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca 1740
caaagtctac gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt 1800
caacagggga gagtgttgac tcgaggcgcg ccgagcatgc atctagggcg gccaattccg 1860
cccctctccc cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt 1920
gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg 1980
aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga 2040
atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa 2100
acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc 2160
tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac 2220
gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag 2280
gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc 2340
acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg 2400
gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccatgg agtttgggct 2460
gagctggctt tttcttgtgg ctattttaaa aggtgtccag tgtgaggtcc agctggtaca 2520
gtctggggct gaggtgaaga agcctggggc tacagtgaaa atctcctgca aggtttctgg 2580
tttctcatta actaactatg gtgtacactg ggtgcgacag gccactggac aagggcttga 2640
gtggatgggt gtgatatgga gtggtggaaa cacagactat aatacacctt tcacatccag 2700
attcaccatc tccagagatg attcaaagaa cacggcgtat ctgcaaatga acagcctgaa 2760
aaccgaggac acggccgtgt attactgtgc cagagccctc acctactatg atgaggagtt 2820
tgcttactgg ggccctggaa cgctggtcac cgtcagctca gcctccacca agggcccatc 2880
ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg 2940
cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac 3000
cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag 3060
cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca 3120
caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca 3180
cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc 3240
cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt 3300
ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt 3360
gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag 3420
cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtcag 3480
caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg 3540
agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag 3600
cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa 3660
tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt 3720
cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc 3780
atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc 3840
tccgggtaaa gattacaagg atgacgacga taagtgagcg gccgcttccc tttagtgagg 3900
gttaatgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag 3960
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 4020
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 4080
tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat 4140
ccgataagga tcgatccggg ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc 4200
caacagttgc gcagcctgaa tggcgaatgg acgcgccctg tagcggcgca ttaagcgcgg 4260
cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 4320
ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 4380
atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 4440
ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4500
tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4560
accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4620
taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta 4680
caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg 4740
cggatctgcg cagcaccatg gcctgaaata acctctgaaa gaggaacttg gttaggtacc 4800
ttctgaggcg gaaagaacca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca 4860
ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt 4920
ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca 4980
gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc 5040
cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg 5100
gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa 5160
aagcttgatt cttctgacac aacagtctcg aacttaaggc tagagccacc atgattgaac 5220
aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact 5280
gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc 5340
gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg 5400
cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg 5460
tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt 5520
catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc 5580
atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag 5640
cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg 5700
ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc 5760
tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt 5820
ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg 5880
ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt 5940
acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct 6000
tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg 6060
atggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat 6120
cgatagcgat aaggatccgc gtatggtgca ctctcagtac aatctgctct gatgccgcat 6180
agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc 6240
tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt 6300
tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc ctatttttat 6360
aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt cggggaaatg 6420
tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga 6480
gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac 6540
atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc 6600
cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca 6660
tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc 6720
caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg 6780
ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac 6840
cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca 6900
taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg 6960
agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac 7020
cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg 7080
caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat 7140
taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg 7200
ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg 7260
cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc 7320
aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc 7380
attggtaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt 7440
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 7500
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 7560
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 7620
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 7680
gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca 7740
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 7800
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 7860
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 7920
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 7980
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 8040
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 8100
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 8160
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatggct cgacagatct 8220




<210> 315
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104E heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 315
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 316
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104E heavy chain variable domain amino
      acid S119
      

<400> 316
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 317
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104E heavy chain variable domain amino
      acid A119
      

<400> 317
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 318
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104E/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 318
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 319
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid S119
      

<400> 319
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 320
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104E/HC-Q111P heavy chain variable
      domain amino acid A119
      

<400> 320
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 321
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104E heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 321
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 322
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104E heavy chain variable
      domain amino acid S119
      

<400> 322
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 323
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104E heavy chain variable
      domain amino acid A119
      

<400> 323
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 324
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 324
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 325
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid S119
      

<400> 325
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 326
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104E/HC-Q111P heavy chain
      variable domain amino acid A119
      

<400> 326
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Glu Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala
        115                 


<210> 327
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 327
Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly
 1               5                  10                  15      
Gly Gly
        


<210> 328
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 328
Gly Ser Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 329
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 329
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr
 1               5                  10                  


<210> 330
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 330
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gln
 1               5                  10                  15  


<210> 331
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 331
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp
 1               5                  10                  


<210> 332
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 332
Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly
 1               5                  10                  


<210> 333
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 333
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser
 1               5                  10                  15      
Leu Asp
        


<210> 334
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 334
Glu Ser Gly Ser Val Ser Ser Glu Glu Leu Ala Phe Arg Ser Leu Asp
 1               5                  10                  15      


<210> 335
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> c-Myc

<400> 335
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10  


<210> 336
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HA

<400> 336
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  


<210> 337
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VSV-G

<400> 337
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
 1               5                  10      


<210> 338
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HSV

<400> 338
Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp
 1               5                  10      


<210> 339
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> V5

<400> 339
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
 1               5                  10                  


<210> 340
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Poly Arg

<400> 340
Arg Arg Arg Arg Arg
 1               5  


<210> 341
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Strep-tag-II

<400> 341
Trp Ser His Pro Gln Phe Glu Lys
 1               5              


<210> 342
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> S tag

<400> 342
Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser
 1               5                  10                  15  


<210> 343
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3x FLAG tag

<400> 343
Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr
 1               5                  10                  15      
Lys Asp Asp Asp Asp Lys
            20          


<210> 344
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> HAT

<400> 344
Lys Asp His Leu Ile His Asn Val His Lys Glu Phe His Ala His Ala
 1               5                  10                  15      
His Asn Lys
            


<210> 345
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> SBP

<400> 345
Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly
 1               5                  10                  15      
Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro
            20                  25                  30          
Gln Gly Gln Arg Glu Pro
        35              


<210> 346
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 346
Gly Gly Gly Gly Ser
 1               5  


<210> 347
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 347
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 348
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 348
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser
            20  


<210> 349
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 349
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
 1               5                  10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser
            20                  25  


<210> 350
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Pseudomonas endotoxin sorting signal
            (Xaa-Asp-Glu-Leu)n, where n = 1-6
      

<220> 
<221> REPEAT         
<222> (1)...(4)
<223> occurring 1, 2, 3, 4, 5, or 6 times
      

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Lys or Arg

<220> 
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = Lys or Arg
      


<220> 
<221> VARIANT        
<222> (13)...(13)
<223> Xaa = Lys or Arg


<220> 
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Lys or Arg


<220> 
<221> VARIANT        
<222> (21)...(21)
<223> Xaa = Lys or Arg


<220> 
<221> VARIANT        
<222> (5)...(24)
<223> these amino acids can be present or absent

<400> 350
Xaa Asp Glu Leu Xaa Asp Glu Leu Xaa Asp Glu Leu Xaa Asp Glu Leu
 1               5                  10                  15      
Xaa Asp Glu Leu Xaa Asp Glu Leu
            20                  


<210> 351
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ala-Leu-Ala-Ala Peptide linker

<400> 351
Ala Leu Ala Ala
 1              


<210> 352
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25C/HC-Y104D heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 352
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Cys Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 353
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104D heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 353
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 354
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-Y104D/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 354
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 355
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104D heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 355
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 356
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-Y104D/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 356
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 357
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104D heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 357
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 358
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S25V/HC-S53G/HC-Y104D/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 358
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Val Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 359
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104D heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 359
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 360
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-Y104D/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 360
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 361
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104D heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 361
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 362
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-T30F/HC-S53G/HC-Y104D/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 362
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 363
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104D heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 363
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 364
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-D72L/HC-Y104D/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 364
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 365
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104D heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 365
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 366
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-S53G/HC-D72L/HC-Y104D/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 366
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Leu Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 367
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104D heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 367
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 368
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-Y104D/HC-Q111P heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 368
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 369
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104D heavy chain amino acid
      S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 369
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 370
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-F27G/HC-S53G/HC-Y104D/HC-Q111P heavy chain
      amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 370
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Gly Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 371
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> DP-h1, 2, 4, 5, 6, 8 heavy chain nucleic acid S119
      

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 371
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 372
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> DP-h1, 2, 4, 5, 6, 8 heavy chain amino acid S119
      

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 372
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 373
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> DP-h9, 12, 14 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 373
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaatac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 374
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> DP-h9, 12, 14 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 374
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 375
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> DP-h10, 13 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 375
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattaact aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaacg ccaagaactc actgtatctg 240
caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 376
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> DP-h10, 13 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 376
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 377
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FDP-h1, 19, 20, 21 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 377
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 378
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FDP-h1, 19, 20, 21 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 378
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 379
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FDP-h2 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 379
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactgggt gcgacaggct 120
cgtggacaac gccttgagtg gataggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 380
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FDP-h2 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 380
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 381
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FDP-h4, 8, 12, 16 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 381
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagact caccatctcc aaggacacct ccaaaaacca ggtggtcctt 240
acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 382
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FDP-h4, 8, 12, 16 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 382
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu
65                  70                  75                  80  
Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 383
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FDP-h5, 9, 13, 17 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 383
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ttcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 384
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FDP-h5, 9, 13, 17 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH3


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 384
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 385
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FDP-h6 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 385
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat caggcagtcc 120
ccatcgagag gccttgagtg gctgggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 386
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FDP-h6 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 386
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 387
<211> 1347
<212> DNA
<213> Artificial Sequence

<220> 
<223> FDP-h10, 14, 18 heavy chain nucleic acid S119

<220> 
<221> V_region       
<222> (1)...(357)

<220> 
<221> C_region       
<222> (358)...(1347)

<400> 387
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggctac agtgaaaatc 60
tcctgcaagg tttctggttt ctcattattt aactatggtg tacactggat ccgccagccc 120
ccagggaagg ggctggagtg gattggtgtg atatggagtg gtggaaacac agactataat 180
acacctttca catccagatt caccatctcc agagatgatt caaagaacac ggcgtatctg 240
caaatgaaca gcctgaaaac cgaggacacg gccgtgtatt actgtgccag agccctcacc 300
tactatgatg atgagtttgc ttactggggc cctggaacgc tggtcaccgt cagctcagcc 360
tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960
tacaagtgca aggtcagcaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320
aagagcctct ccctgtctcc gggtaaa                                     1347

<210> 388
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> FDP-h10, 14, 18 heavy chain amino acid S119

<220> 
<221> DOMAIN         
<222> (1)...(119)
<223> variable domain

<220> 
<221> DOMAIN         
<222> (120)...(217)
<223> CH1

<220> 
<221> DOMAIN         
<222> (218)...(232)
<223> hinge region

<220> 
<221> DOMAIN         
<222> (233)...(342)
<223> CH2


<220> 
<221> DOMAIN         
<222> (343)...(449)
<223> CH3

<400> 388
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Ser Leu Phe Asn Tyr
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Asp Glu Phe Ala Tyr Trp Gly Pro Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 389
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> Bryodin
      

<400> 389
Asp Val Ser Phe Arg Leu Ser Gly Ala Thr Thr Thr Ser Tyr Gly Val
 1               5                  10                  15      
Phe Ile Lys Asn Leu Arg Glu Ala Leu Pro Tyr Glu Arg Lys Val Tyr
            20                  25                  30          
Asn Ile Pro Leu Leu Arg Ser Ser Ile Ser Gly Arg Tyr Thr Leu Leu
        35                  40                  45              
His Leu Thr Asn Tyr Ala Asp Glu Thr Ile Ser Val Ala Val Asp Val
    50                  55                  60                  
Thr Asn Val Tyr Ile Met Gly Tyr Leu Ala Gly Asp Val Ser Tyr Phe
65                  70                  75                  80  
Phe Asn Glu Ala Ser Ala Thr Glu Ala Ala Lys Phe Val Phe Lys Asp
                85                  90                  95      
Ala Lys Lys Lys Val Thr Leu Pro Tyr Ser Gly Asn Tyr Glu Arg Leu
            100                 105                 110         
Gln Thr Ala Ala Gly Lys Ile Arg Glu Asn Ile Pro Leu Gly Leu Pro
        115                 120                 125             
Ala Leu Asp Ser Ala Ile Thr Thr Leu Tyr Tyr Tyr Thr Ala Ser Ser
    130                 135                 140                 
Ala Ala Ser Ala Leu Leu Val Leu Ile Gln Ser Thr Ala Glu Ser Ala
145                 150                 155                 160 
Arg Tyr Lys Phe Ile Glu Gln Gln Ile Gly Lys Arg Val Asp Lys Thr
                165                 170                 175     
Phe Leu Pro Ser Leu Ala Thr Ile Ser Leu Glu Asn Asn Trp Ser Ala
            180                 185                 190         
Leu Ser Lys Gln Ile Gln Ile Ala Ser Thr Asn Asn Gly Gln Phe Glu
        195                 200                 205             
Ser Pro Val Val Leu Ile Asp Gly Asn Asn Gln Arg Val Ser Ile Thr
    210                 215                 220                 
Asn Ala Ser Ala Arg Val Val Thr Ser Asn Ile Ala Leu Leu Leu Asn
225                 230                 235                 240 
Arg Asn Asn Ile Ala
                245 


<210> 390
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> Saporin-6

<400> 390
Val Thr Ser Ile Thr Leu Asp Leu Val Asn Pro Thr Ala Gly Gln Tyr
 1               5                  10                  15      
Ser Ser Phe Val Asp Lys Ile Arg Asn Asn Val Lys Asp Pro Asn Leu
            20                  25                  30          
Lys Tyr Gly Gly Thr Asp Ile Ala Val Ile Pro Pro Ser Lys Glu Lys
        35                  40                  45              
Phe Leu Arg Ile Asn Phe Gln Ser Ser Arg Gly Thr Val Ser Leu Gly
    50                  55                  60                  
Leu Lys Arg Asp Asn Leu Tyr Val Val Ala Tyr Leu Ala Met Asp Asn
65                  70                  75                  80  
Thr Asn Val Asn Arg Ala Tyr Tyr Phe Arg Ser Glu Ile Thr Ser Ala
                85                  90                  95      
Glu Ser Thr Ala Leu Phe Pro Glu Ala Thr Thr Ala Asn Gln Lys Ala
            100                 105                 110         
Leu Glu Tyr Thr Glu Asp Tyr Gln Ser Ile Glu Lys Asn Ala Gln Ile
        115                 120                 125             
Thr Gln Gly Asp Gln Ser Arg Lys Glu Leu Gly Leu Gly Ile Asp Leu
    130                 135                 140                 
Leu Ser Thr Ser Met Glu Ala Val Asn Lys Lys Ala Arg Val Val Lys
145                 150                 155                 160 
Asp Glu Ala Arg Phe Leu Leu Ile Ala Ile Gln Met Thr Ala Glu Ala
                165                 170                 175     
Ala Arg Phe Arg Tyr Ile Gln Asn Leu Val Ile Lys Asn Phe Pro Asn
            180                 185                 190         
Lys Phe Asn Ser Glu Asn Lys Val Ile Gln Phe Glu Val Asn Trp Lys
        195                 200                 205             
Lys Ile Ser Thr Ala Ile Tyr Gly Asp Ala Lys Asn Gly Val Phe Asn
    210                 215                 220                 
Lys Asp Tyr Asp Phe Gly Phe Gly Lys Val Arg Gln Val Lys Asp Leu
225                 230                 235                 240 
Gln Met Gly Leu Leu Met Tyr Leu Gly Lys Pro Lys Ser Ser Asn Glu
                245                 250                 255     
Ala Asn Ser Thr Val Arg His Tyr Gly Pro Leu Lys Pro Thr Leu Leu
            260                 265                 270         
Ile Thr
        


<210> 391
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-Viral Protein MAP

<400> 391
Ala Pro Thr Leu Glu Thr Ile Ala Ser Leu Asp Leu Asn Asn Pro Thr
 1               5                  10                  15      
Thr Tyr Leu Ser Phe Ile Thr Asn Ile Arg Thr Lys Val Ala Asp Lys
            20                  25                  30          
Thr Glu Gln Cys Thr Ile Gln Lys Ile Ser Lys Thr Phe Thr Gln Arg
        35                  40                  45              
Tyr Ser Tyr Ile Asp Leu Ile Val Ser Ser Thr Gln Lys Ile Thr Leu
    50                  55                  60                  
Ala Ile Asp Met Ala Asp Leu Tyr Val Leu Gly Tyr Ser Asp Ile Ala
65                  70                  75                  80  
Asn Asn Lys Gly Arg Ala Phe Phe Phe Lys Asp Val Thr Glu Ala Val
                85                  90                  95      
Ala Asn Asn Phe Phe Pro Gly Ala Thr Gly Thr Asn Arg Ile Lys Leu
            100                 105                 110         
Thr Phe Thr Gly Ser Tyr Gly Asp Leu Glu Lys Asn Gly Gly Leu Arg
        115                 120                 125             
Lys Asp Asn Pro Leu Gly Ile Phe Arg Leu Glu Asn Ser Ile Val Asn
    130                 135                 140                 
Ile Tyr Gly Lys Ala Gly Asp Val Lys Lys Gln Ala Lys Phe Phe Leu
145                 150                 155                 160 
Leu Ala Ile Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Ser
                165                 170                 175     
Asp Lys Ile Pro Ser Glu Lys Tyr Glu Glu Val Thr Val Asp Glu Tyr
            180                 185                 190         
Met Thr Ala Leu Glu Asn Asn Trp Ala Lys Leu Ser Thr Ala Val Tyr
        195                 200                 205             
Asn Ser Lys Pro Ser Thr Thr Thr Ala Thr Lys Cys Gln Leu Ala Thr
    210                 215                 220                 
Ser Pro Val Thr Ile Ser Pro Trp Ile Phe Lys Thr Val Glu Glu Ile
225                 230                 235                 240 
Lys Leu Val Met Gly Leu Leu Lys Ser Ser
                245                 250 


<210> 392
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<223> Shiga Toxin A-Chain

<400> 392
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser
 1               5                  10                  15      
Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser
            20                  25                  30          
Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn
        35                  40                  45              
Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe
    50                  55                  60                  
Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly
65                  70                  75                  80  
Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser
                85                  90                  95      
His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser
            100                 105                 110         
Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met
        115                 120                 125             
Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser
    130                 135                 140                 
His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg
145                 150                 155                 160 
Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg
                165                 170                 175     
Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met
            180                 185                 190         
Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser
        195                 200                 205             
Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile
    210                 215                 220                 
Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu
225                 230                 235                 240 
Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu
                245                 250                 255     
Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His
            260                 265                 270         
Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg
        275                 280                 285             
Arg Thr Ile Ser Ser
    290             


<210> 393
<211> 319
<212> PRT
<213> Artificial Sequence

<220> 
<223> Shiga-Like Toxin Subunit A (Verotoxin 2)

<400> 393
Met Lys Cys Ile Leu Phe Lys Trp Val Leu Cys Leu Leu Leu Gly Phe
 1               5                  10                  15      
Ser Ser Val Ser Tyr Ser Arg Glu Phe Thr Ile Asp Phe Ser Thr Gln
            20                  25                  30          
Gln Ser Tyr Val Ser Ser Leu Asn Ser Ile Arg Thr Glu Ile Ser Thr
        35                  40                  45              
Pro Leu Glu His Ile Ser Gln Gly Thr Thr Ser Val Ser Val Ile Asn
    50                  55                  60                  
His Thr Pro Pro Gly Ser Tyr Phe Ala Val Asp Ile Arg Gly Leu Asp
65                  70                  75                  80  
Val Tyr Gln Ala Arg Phe Asp His Leu Arg Leu Ile Ile Glu Gln Asn
                85                  90                  95      
Asn Leu Tyr Val Ala Gly Phe Val Asn Thr Ala Thr Asn Thr Phe Tyr
            100                 105                 110         
Arg Phe Ser Asp Phe Thr His Ile Ser Val Pro Gly Val Thr Thr Val
        115                 120                 125             
Ser Met Thr Thr Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Ala
    130                 135                 140                 
Leu Glu Arg Ser Gly Met Gln Ile Ser Arg His Ser Leu Val Ser Ser
145                 150                 155                 160 
Tyr Leu Ala Leu Met Glu Phe Ser Gly Asn Thr Met Thr Arg Asp Ala
                165                 170                 175     
Ser Arg Ala Val Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg
            180                 185                 190         
Phe Arg Gln Ile Gln Arg Glu Phe Arg Gln Ala Leu Ser Glu Thr Ala
        195                 200                 205             
Pro Val Tyr Thr Met Thr Pro Gly Asp Val Asp Leu Thr Leu Asn Trp
    210                 215                 220                 
Gly Arg Ile Ser Asn Val Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val
225                 230                 235                 240 
Arg Val Gly Arg Ile Ser Phe Asn Asn Ile Ser Ala Ile Leu Gly Thr
                245                 250                 255     
Val Ala Val Ile Leu Asn Cys His His Gln Gly Ala Arg Ser Val Arg
            260                 265                 270         
Ala Val Asn Glu Glu Ser Gln Pro Glu Cys Gln Ile Thr Gly Asp Arg
        275                 280                 285             
Pro Val Ile Lys Ile Asn Asn Thr Leu Trp Glu Ser Asn Thr Ala Ala
    290                 295                 300                 
Ala Phe Leu Asn Arg Lys Ser Gln Phe Leu Tyr Thr Thr Gly Lys
305                 310                 315                 


<210> 394
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> Trichosanthin

<400> 394
Asp Val Ser Phe Arg Leu Ser Gly Ala Thr Ser Ser Ser Tyr Gly Val
 1               5                  10                  15      
Phe Ile Ser Asn Leu Arg Lys Ala Leu Pro Asn Glu Arg Lys Leu Tyr
            20                  25                  30          
Asp Ile Pro Leu Leu Arg Ser Ser Leu Pro Gly Ser Gln Arg Tyr Ala
        35                  40                  45              
Leu Ile His Leu Thr Asn Tyr Ala Asp Glu Thr Ile Ser Val Ala Ile
    50                  55                  60                  
Asp Val Thr Asn Val Tyr Ile Met Gly Tyr Arg Ala Gly Asp Thr Ser
65                  70                  75                  80  
Tyr Phe Phe Asn Glu Ala Ser Ala Thr Glu Ala Ala Lys Tyr Val Phe
                85                  90                  95      
Lys Asp Ala Met Arg Lys Val Thr Leu Pro Tyr Ser Gly Asn Tyr Glu
            100                 105                 110         
Arg Leu Gln Thr Ala Ala Gly Lys Ile Arg Glu Asn Ile Pro Leu Gly
        115                 120                 125             
Leu Pro Ala Leu Asp Ser Ala Ile Thr Thr Leu Phe Tyr Tyr Asn Ala
    130                 135                 140                 
Asn Ser Ala Ala Ser Ala Leu Met Val Leu Ile Gln Ser Thr Ser Glu
145                 150                 155                 160 
Ala Ala Arg Tyr Lys Phe Ile Glu Gln Gln Ile Gly Lys Arg Val Asp
                165                 170                 175     
Lys Thr Phe Leu Pro Ser Leu Ala Ile Ile Ser Leu Glu Asn Ser Trp
            180                 185                 190         
Ser Ala Leu Ser Lys Gln Ile Gln Ile Ala Ser Thr Asn Asn Gly Gln
        195                 200                 205             
Phe Glu Ser Pro Val Val Leu Ile Asn Ala Gln Asn Gln Arg Val Thr
    210                 215                 220                 
Ile Thr Asn Val Asp Ala Gly Val Val Thr Ser Asn Ile Ala Leu Leu
225                 230                 235                 240 
Leu Asn Arg Asn Asn Met Ala
                245         

