
                                SEQUENCE LISTING

<110> Verenium Corporation
      Pop, Cristina
      Davenport, Adrienne Huston
      Han, Yun 
      Pratt, Michael
      Wong, Kelvin Ning 
      Zhang, Bin
      Ren, Dongmei
  

<120> CONTROLLED BREAK ENZYME FORMULATIONS
  

<130> VEREN.078WO/D2650-1WO

<150> 61/878224
<151> 2013-09-16

<150> 61/916366
<151> 2013-12-16
        
<160> 21

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> Open reading frame encoding SEQ ID NO:2 conveying
      enhanced protein expression

<400> 1
atgggcgtcg atccgtttga acgtaacaaa atcttgggcc gcggcattaa tatcggcaat 60
gcgctcgaag caccaaatga aggcgactgg ggagtggtga taaaagatga gttcttcgac 120
attataaaag aagccggttt ctctcatgtt cgaattccaa taagatggag tacgcacgct 180
caggcgtttc ctccttataa aatcgagcct tctttcttca aaagagtgga tgaagtgata 240
aacggagccc tgaaaagagg actggctgtt gttataaata ttcatcacta cgaggagtta 300
atgaatgatc cagaagaaca caaggaaaga tttcttgctc tttggaaaca aattgctgat 360
cgttataaag actatcccga aactctattt tttgaaattc tgaatgaacc tcacggaaat 420
cttactccgg aaaaatggaa tgaactgctt gaggaagctc taaaagttat aagatcaatt 480
gacaaaaagc acactgtgat tataggcaca gctgaatggg ggggtatatc tgcccttgaa 540
aaactgaggg tcccaaaatg ggaaaaaaat gcgatagtta caattcacta ctacaatcct 600
ttcgaattta cccatcaagg agctgagtgg gtgcctggat ctgagaaatg gttgggaaga 660
aagtggggat ctccagatga tcagaaacat ttgatagaag aattcaattt tatagaagaa 720
tggtcaaaaa agaacaaaag accaatttac ataggtgagt ttggtgccta cagaaaagct 780
gaccttgaat caagaataaa atggacctcc tttgtcgttc gcgaagccga gaaaaggggg 840
tggagctggg catactggga attttgttcc ggttttggtg tttatgatcc tctgagaaaa 900
cagtggaata aagatctttt agaagcttta ataggaggag atagcattga atga       954

<210> 2
<211> 317
<212> PRT
<213> Thermotoga maritima

<400> 2
Met Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg Gly Ile
 1               5                  10                  15      
Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp Gly Val
            20                  25                  30          
Val Ile Lys Asp Glu Phe Phe Asp Ile Ile Lys Glu Ala Gly Phe Ser
        35                  40                  45              
His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Gln Ala Phe Pro
    50                  55                  60                  
Pro Tyr Lys Ile Glu Pro Ser Phe Phe Lys Arg Val Asp Glu Val Ile
65                  70                  75                  80  
Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Ile His His
                85                  90                  95      
Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg Phe Leu
            100                 105                 110         
Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro Glu Thr
        115                 120                 125             
Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr Pro Glu
    130                 135                 140                 
Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg Ser Ile
145                 150                 155                 160 
Asp Lys Lys His Thr Val Ile Ile Gly Thr Ala Glu Trp Gly Gly Ile
                165                 170                 175     
Ser Ala Leu Glu Lys Leu Arg Val Pro Lys Trp Glu Lys Asn Ala Ile
            180                 185                 190         
Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln Gly Ala
        195                 200                 205             
Glu Trp Val Pro Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp Gly Ser
    210                 215                 220                 
Pro Asp Asp Gln Lys His Leu Ile Glu Glu Phe Asn Phe Ile Glu Glu
225                 230                 235                 240 
Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe Gly Ala
                245                 250                 255     
Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser Phe Val
            260                 265                 270         
Val Arg Glu Ala Glu Lys Arg Gly Trp Ser Trp Ala Tyr Trp Glu Phe
        275                 280                 285             
Cys Ser Gly Phe Gly Val Tyr Asp Pro Leu Arg Lys Gln Trp Asn Lys
    290                 295                 300                 
Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu
305                 310                 315         


<210> 3
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> Open reading frame encoding SEQ ID NO:2

<400> 3
atgggtgttg atccttttga aaggaacaaa atattgggaa gaggcattaa tataggaaat 60
gcgcttgaag caccaaatga gggagactgg ggagtggtga taaaagatga gttcttcgac 120
attataaaag aagccggttt ctctcatgtt cgaattccaa taagatggag tacgcacgct 180
caggcgtttc ctccttataa aatcgagcct tctttcttca aaagagtgga tgaagtgata 240
aacggagccc tgaaaagagg actggctgtt gttataaata ttcatcacta cgaggagtta 300
atgaatgatc cagaagaaca caaggaaaga tttcttgctc tttggaaaca aattgctgat 360
cgttataaag actatcccga aactctattt tttgaaattc tgaatgaacc tcacggaaat 420
cttactccgg aaaaatggaa tgaactgctt gaggaagctc taaaagttat aagatcaatt 480
gacaaaaagc acactgtgat tataggcaca gctgaatggg ggggtatatc tgcccttgaa 540
aaactgaggg tcccaaaatg ggaaaaaaat gcgatagtta caattcacta ctacaatcct 600
ttcgaattta cccatcaagg agctgagtgg gtgcctggat ctgagaaatg gttgggaaga 660
aagtggggat ctccagatga tcagaaacat ttgatagaag aattcaattt tatagaagaa 720
tggtcaaaaa agaacaaaag accaatttac ataggtgagt ttggtgccta cagaaaagct 780
gaccttgaat caagaataaa atggacctcc tttgtcgttc gcgaagccga gaaaaggggg 840
tggagctggg catactggga attttgttcc ggttttggtg tttatgatcc tctgagaaaa 900
cagtggaata aagatctttt agaagcttta ataggaggag atagcattga ataa       954

<210> 4
<211> 976
<212> DNA
<213> Artificial Sequence

<220> 
<223> 5' region and open reading frame encoding SEQ ID
      NO:2 having modest increased expression

<400> 4
tctactagtt aggaggtaac ttatgggcgt cgatccgttt gaacgtaaca aaatcttggg 60
ccgcggcatt aatatcggca atgcgctcga agcaccaaat gaaggcgact ggggagtggt 120
gataaaagat gagttcttcg acattataaa agaagccggt ttctctcatg ttcgaattcc 180
aataagatgg agtacgcacg ctcaggcgtt tcctccttat aaaatcgagc cttctttctt 240
caaaagagtg gatgaagtga taaacggagc cctgaaaaga ggactggctg ttgttataaa 300
tattcatcac tacgaggagt taatgaatga tccagaagaa cacaaggaaa gatttcttgc 360
tctttggaaa caaattgctg atcgttataa agactatccc gaaactctat tttttgaaat 420
tctgaatgaa cctcacggaa atcttactcc ggaaaaatgg aatgaactgc ttgaggaagc 480
tctaaaagtt ataagatcaa ttgacaaaaa gcacactgtg attataggca cagctgaatg 540
ggggggtata tctgcccttg aaaaactgag ggtcccaaaa tgggaaaaaa atgcgatagt 600
tacaattcac tactacaatc ctttcgaatt tacccatcaa ggagctgagt gggtgcctgg 660
atctgagaaa tggttgggaa gaaagtgggg atctccagat gatcagaaac atttgataga 720
agaattcaat tttatagaag aatggtcaaa aaagaacaaa agaccaattt acataggtga 780
gtttggtgcc tacagaaaag ctgaccttga atcaagaata aaatggacct cctttgtcgt 840
tcgcgaagcc gagaaaaggg ggtggagctg ggcatactgg gaattttgtt ccggttttgg 900
tgtttatgat cctctgagaa aacagtggaa taaagatctt ttagaagctt taataggagg 960
agatagcatt gaatga                                                 976

<210> 5
<211> 954
<212> DNA
<213> Thermotoga maritima

<400> 5
atgggtgttg atccttttga aaggaacaaa atattgggaa gaggcattaa tataggaaat 60
gcgcttgaag caccaaatga gggagactgg ggagtggtga taaaagatga gttcttcgac 120
attataaaag aagccggttt ctctcatgtt cgaattccaa taagatggag tacgcacgct 180
tacgcgtttc ctccttataa aatcatggat cgcttcttca aaagagtgga tgaagtgata 240
aacggagccc tgaaaagagg actggctgtt gttataaata ttcatcacta cgaggagtta 300
atgaatgatc cagaagaaca caaggaaaga tttcttgctc tttggaaaca aattgctgat 360
cgttataaag actatcccga aactctattt tttgaaattc tgaatgaacc tcacggaaat 420
cttactccgg aaaaatggaa tgaactgctt gaggaagctc taaaagttat aagatcaatt 480
gacaaaaagc acactataat tataggcaca gctgaatggg ggggtatatc tgcccttgaa 540
aaactgtctg tcccaaaatg ggaaaaaaat tctatagtta caattcacta ctacaatcct 600
ttcgaattta cccatcaagg agctgagtgg gtggaaggat ctgagaaatg gttgggaaga 660
aagtggggat ctccagatga tcagaaacat ttgatagaag aattcaattt tatagaagaa 720
tggtcaaaaa agaacaaaag accaatttac ataggtgagt ttggtgccta cagaaaagct 780
gaccttgaat caagaataaa atggacctcc tttgtcgttc gcgaaatgga gaaaaggaga 840
tggagctggg catactggga attttgttcc ggttttggtg tttatgatac tctgagaaaa 900
acctggaata aagatctttt agaagcttta ataggaggag atagcattga ataa       954

<210> 6
<211> 317
<212> PRT
<213> Thermotoga maritima

<220> 
<221> DOMAIN         
<222> (19)...(296)
<223> Cellulase (glycosyl hydrolase family 5)

<400> 6
Met Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg Gly Ile
 1               5                  10                  15      
Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp Gly Val
            20                  25                  30          
Val Ile Lys Asp Glu Phe Phe Asp Ile Ile Lys Glu Ala Gly Phe Ser
        35                  40                  45              
His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Tyr Ala Phe Pro
    50                  55                  60                  
Pro Tyr Lys Ile Met Asp Arg Phe Phe Lys Arg Val Asp Glu Val Ile
65                  70                  75                  80  
Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Ile His His
                85                  90                  95      
Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg Phe Leu
            100                 105                 110         
Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro Glu Thr
        115                 120                 125             
Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr Pro Glu
    130                 135                 140                 
Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg Ser Ile
145                 150                 155                 160 
Asp Lys Lys His Thr Ile Ile Ile Gly Thr Ala Glu Trp Gly Gly Ile
                165                 170                 175     
Ser Ala Leu Glu Lys Leu Ser Val Pro Lys Trp Glu Lys Asn Ser Ile
            180                 185                 190         
Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln Gly Ala
        195                 200                 205             
Glu Trp Val Glu Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp Gly Ser
    210                 215                 220                 
Pro Asp Asp Gln Lys His Leu Ile Glu Glu Phe Asn Phe Ile Glu Glu
225                 230                 235                 240 
Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe Gly Ala
                245                 250                 255     
Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser Phe Val
            260                 265                 270         
Val Arg Glu Met Glu Lys Arg Arg Trp Ser Trp Ala Tyr Trp Glu Phe
        275                 280                 285             
Cys Ser Gly Phe Gly Val Tyr Asp Thr Leu Arg Lys Thr Trp Asn Lys
    290                 295                 300                 
Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu
305                 310                 315         


<210> 7
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated polynucleotide

<400> 7
atgggtgttg atccttttga aaggaacaaa atattgggaa gaggcattaa tataggaaat 60
gcgcttgaag caccaaatga gggcgactgg ggagtcgtga taaaagatga gttcttcgac 120
attataaaag aagccggttt ctctcatgtt cgaattccaa taagatggag tacgcacgct 180
tacgcgtttc ctccttataa aatcatggat cgcttcttca aaagagtgga tgaagtgata 240
aacggagccc tgaaaagagg actggctgtt gttataaata ttcatcacta cgaggagtta 300
atgaatgatc cagaagaaca caaggaaaga tttcttgctc tttggaaaca aattgctgat 360
cgttataaag actatcccga aactctattt tttgaaattc tgaatgaacc tcacggaaat 420
cttactccgg aaaaatggaa tgaactgctt gaggaagctc taaaagttat aagatcaatt 480
gacaaaaagc acactataat tataggcaca gctgaatggg ggggtatatc tgcccttgaa 540
aaactgtctg tcccaaaatg ggaaaaaaat tctatagtta caattcacta ctacaatcct 600
ttcgaattta cccatcaagg agctgagtgg gtggaaggat ctgagaaatg gttgggaaga 660
aagtggggat ctccagatga tcagaaacat ttgatagaag aattcaattt tatagaagaa 720
tggtcaaaaa agaacaaaag accaatttac ataggtgagt ttggtgccta cagaaaagct 780
gaccttgaat caagaataaa atggacctcc tttgtcgttc gcgaaatgga gaaaaggaga 840
tggagctggg catactggga attttgttcc ggttttggtg tttatgatac tctgagaaaa 900
acctggaata aagatctttt agaagcttta ataggaggag atagcattga ataa       954

<210> 8
<211> 974
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated polynucleotide

<400> 8
atgggtgttg atccttttga aaggaacaaa atattgggaa gaggcattaa tataggaaat 60
gcgcttgaag caccaaatga gggagactgg ggagtggtga taaaagatga gtatttcgac 120
attataaaag aagccggttt ctctcatgtt cgaattccaa taagatggag tacgcacgct 180
caggcgtttc ctccttataa aatcgaggat cgcttcttca aaagagtgga tgaagtgata 240
aacggagccc tgaaaagagg actggctgtt gttataaatc agcatcacta cgaggagtta 300
atgaatgatc cagaagaaca caaggaaaga tttcttgctc tttggaaaca aattgctgat 360
cgttataaag actatcccga aactctattt tttgaaattc tgaatgaacc tcacggaaat 420
cttactccgg aaaaatggaa tgaactgctt gaggaagctc taaaagttat aagatcaatt 480
gacaaaaagc acactataat tataggcaca gctgaatggg ggggtatatc tgcccttgaa 540
aaactgaggg tcccaaaatg ggaaaaaaat gcgatagtta caattcacta ctacaatcct 600
ttcgaattta cccatcaagg agctgagtgg gtggaaggat ctgagaaatg gttgggaaga 660
aagtggggat ctccagatga tcagaaacat ttgatagaag aattcaattt tatagaagaa 720
tggtcaaaaa agaacaaaag accaatttac ataggtgagt ttggtgccta cagaaaagct 780
gaccttgaat caagaataaa atggacctcc tttgtcgttc gcgaagctga gaaaaggaga 840
tggagctggg catactggga attttgttcc ggttttggtg tttatgatac tctgagaaaa 900
acctggaata aagatctttt agaagcttta ataggaggag atagcattga ataacaccat 960
tccaagatgg cgtg                                                   974

<210> 9
<211> 317
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated polypeptide

<400> 9
Met Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg Gly Ile
 1               5                  10                  15      
Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp Gly Val
            20                  25                  30          
Val Ile Lys Asp Glu Tyr Phe Asp Ile Ile Lys Glu Ala Gly Phe Ser
        35                  40                  45              
His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Gln Ala Phe Pro
    50                  55                  60                  
Pro Tyr Lys Ile Glu Asp Arg Phe Phe Lys Arg Val Asp Glu Val Ile
65                  70                  75                  80  
Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Gln His His
                85                  90                  95      
Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg Phe Leu
            100                 105                 110         
Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro Glu Thr
        115                 120                 125             
Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr Pro Glu
    130                 135                 140                 
Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg Ser Ile
145                 150                 155                 160 
Asp Lys Lys His Thr Ile Ile Ile Gly Thr Ala Glu Trp Gly Gly Ile
                165                 170                 175     
Ser Ala Leu Glu Lys Leu Arg Val Pro Lys Trp Glu Lys Asn Ala Ile
            180                 185                 190         
Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln Gly Ala
        195                 200                 205             
Glu Trp Val Glu Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp Gly Ser
    210                 215                 220                 
Pro Asp Asp Gln Lys His Leu Ile Glu Glu Phe Asn Phe Ile Glu Glu
225                 230                 235                 240 
Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe Gly Ala
                245                 250                 255     
Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser Phe Val
            260                 265                 270         
Val Arg Glu Ala Glu Lys Arg Arg Trp Ser Trp Ala Tyr Trp Glu Phe
        275                 280                 285             
Cys Ser Gly Phe Gly Val Tyr Asp Thr Leu Arg Lys Thr Trp Asn Lys
    290                 295                 300                 
Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu
305                 310                 315 


<210> 10
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated polynucleotide

<400> 10
atgggtgttg atccttttga aaggaacaaa atattgggaa gaggcattaa tataggaaat 60
gcgcttgaag caccaaatga gggagactgg ggagtggtga taaaagatga gtatttcgac 120
attataaaag aagccggttt ctctcatgtt cgaattccaa taagatggag tacgcacgct 180
caggcgtttc ctccttataa aatcgaggat tctttcttca aaagagtgga tgaagtgata 240
aacggagccc tgaaaagagg actggctgtt gttataaata ttcatcacta cgaggagtta 300
atgaatgatc cagaagaaca caaggaaaga tttcttgctc tttggaaaca aattgctgat 360
cgttataaag actatcccga aactctattt tttgaaattc tgaatgaacc tcacggaaat 420
cttactccgg aaaaatggaa tgaactgctt gaggaagctc taaaagttat aagatcaatt 480
gacaaaaagc acactgtgat tataggcaca gctgaatggg ggggtatatc tgcccttgaa 540
aaactgaggg tcccaaaatg ggaaaaaaat gcgatagtta caattcacta ctacaatcct 600
ttcgaattta cccatcaagg agctgagtgg gtgcctggat ctgagaaatg gttgggaaga 660
aagtggggat ctccagatga tcagaaacat gtgatagaag aattcaattt tatagaagaa 720
tggtcaaaaa agaacaaaag accaatttac ataggtgagt ttggtgccta cagaaaagct 780
gaccttgaat caagaataaa atggacctcc tttgtcgttc gcgaagccga gaaaaggggg 840
tggagctggg catactggga attttgttcc ggttttggtg tttatgatcc tctgagaaaa 900
cagtggaata aagatctttt agaagctcta ataggaggag atagcattga ataa       954

<210> 11
<211> 317
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated polypeptide

<400> 11
Met Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg Gly Ile
 1               5                  10                  15      
Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp Gly Val
            20                  25                  30          
Val Ile Lys Asp Glu Tyr Phe Asp Ile Ile Lys Glu Ala Gly Phe Ser
        35                  40                  45              
His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Gln Ala Phe Pro
    50                  55                  60                  
Pro Tyr Lys Ile Glu Asp Ser Phe Phe Lys Arg Val Asp Glu Val Ile
65                  70                  75                  80  
Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Ile His His
                85                  90                  95      
Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg Phe Leu
            100                 105                 110         
Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro Glu Thr
        115                 120                 125             
Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr Pro Glu
    130                 135                 140                 
Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg Ser Ile
145                 150                 155                 160 
Asp Lys Lys His Thr Val Ile Ile Gly Thr Ala Glu Trp Gly Gly Ile
                165                 170                 175     
Ser Ala Leu Glu Lys Leu Arg Val Pro Lys Trp Glu Lys Asn Ala Ile
            180                 185                 190         
Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln Gly Ala
        195                 200                 205             
Glu Trp Val Pro Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp Gly Ser
    210                 215                 220                 
Pro Asp Asp Gln Lys His Val Ile Glu Glu Phe Asn Phe Ile Glu Glu
225                 230                 235                 240 
Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe Gly Ala
                245                 250                 255     
Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser Phe Val
            260                 265                 270         
Val Arg Glu Ala Glu Lys Arg Gly Trp Ser Trp Ala Tyr Trp Glu Phe
        275                 280                 285             
Cys Ser Gly Phe Gly Val Tyr Asp Pro Leu Arg Lys Gln Trp Asn Lys
    290                 295                 300                 
Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu
305                 310                 315         


<210> 12
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated polynucleotide

<400> 12
atgggtgttg atccttttga aaggaacaaa atattgggaa gaggcattaa tataggaaat 60
gcgcttgaag caccaaatga gggagactgg ggagtggtga taaaagatga gttcttcgac 120
attataaaag aagccggttt ctctcatgtt cgaattccaa taagatggag tacgcacgct 180
caggcgtttc ctccttataa aatcgaggat tctttcttca aaagagtgga tgaagtgata 240
aacggagccc tgaaaagagg actggctgtt gttataaatc agcatcacta cgaggagtta 300
atgaatgatc cagaagaaca caaggaaaga tttcttgctc tttggaaaca aattgctgat 360
cgttataaag actatcccga aactctattt tttgaaattc tgaatgaacc tcacggaaat 420
cttactccgg aaaaatggaa tgaactgctt gaggaagctc taaaagttat aagatcaatt 480
gacaaaaagc acactgtgat tataggcaca gctgaatggg ggggtatatc tgcccttgaa 540
aaactgaggg tcccaaaatg ggaaaaaaat gcgatagtta caattcacta ctacaatcct 600
ttcgaattta cccatcaagg agctgagtgg gtgcctggat ctgagaaatg gttgggaaga 660
aagtggggat ctccagatga tcagaaacat ttgatagaag aattcaattt tatagaagaa 720
tggtcaaaaa agaacaaaag accaatttac ataggtgagt ttggtgccta cagaaaagct 780
gaccttgaat caagaataaa atggacctcc tttgtcgttc gcgaagccga gaaaaggggg 840
tggagctggg catactggga attttgttcc ggttttggtg tttatgatcc tctgagaaaa 900
cagtggaata aagatctttt agaagcttta ataggaggag atagcattga ataa       954

<210> 13
<211> 317
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated polypeptide

<400> 13
Met Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg Gly Ile
 1               5                  10                  15      
Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp Gly Val
            20                  25                  30          
Val Ile Lys Asp Glu Phe Phe Asp Ile Ile Lys Glu Ala Gly Phe Ser
        35                  40                  45              
His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Gln Ala Phe Pro
    50                  55                  60                  
Pro Tyr Lys Ile Glu Asp Ser Phe Phe Lys Arg Val Asp Glu Val Ile
65                  70                  75                  80  
Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Gln His His
                85                  90                  95      
Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg Phe Leu
            100                 105                 110         
Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro Glu Thr
        115                 120                 125             
Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr Pro Glu
    130                 135                 140                 
Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg Ser Ile
145                 150                 155                 160 
Asp Lys Lys His Thr Val Ile Ile Gly Thr Ala Glu Trp Gly Gly Ile
                165                 170                 175     
Ser Ala Leu Glu Lys Leu Arg Val Pro Lys Trp Glu Lys Asn Ala Ile
            180                 185                 190         
Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln Gly Ala
        195                 200                 205             
Glu Trp Val Pro Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp Gly Ser
    210                 215                 220                 
Pro Asp Asp Gln Lys His Leu Ile Glu Glu Phe Asn Phe Ile Glu Glu
225                 230                 235                 240 
Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe Gly Ala
                245                 250                 255     
Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser Phe Val
            260                 265                 270         
Val Arg Glu Ala Glu Lys Arg Gly Trp Ser Trp Ala Tyr Trp Glu Phe
        275                 280                 285             
Cys Ser Gly Phe Gly Val Tyr Asp Pro Leu Arg Lys Gln Trp Asn Lys
    290                 295                 300                 
Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu
305                 310                 315         


<210> 14
<211> 972
<212> DNA
<213> Thermotoga sp.

<400> 14
atggaacagt cagttgctga aagtgatagc aactcagcat ttgaatacaa caaaatggta 60
ggtaaaggag taaatattgg aaatgcttta gaagctcctt tcgaaggagc ttggggagta 120
agaattgagg atgaatattt tgagataata aagaaaaggg gatttgattc tgttaggatt 180
cccataagat ggtcagcaca tatatccgaa aagccaccat atgatattga caggaatttc 240
ctcgaaagag ttaaccatgt tgtcgatagg gctcttgaga ataatttaac agtaatcatc 300
aatacgcacc attttgaaga actctatcaa gaaccggata aatacggcga tgttttggtg 360
gaaatttgga gacagattgc aaaattcttt aaagattacc cggaaaatct gttctttgaa 420
atctacaacg agcctgctca gaacttgaca gctgaaaaat ggaacgcact ttatccaaaa 480
gtgctcaaag ttatcaggga gagcaatcca acccggattg tcattatcga tgctccaaac 540
tgggcacact atagcgcagt gagaagtcta aaattagtca acgacaaacg catcattgtt 600
tccttccatt actacgaacc tttcaaattc acacatcagg gtgccgaatg ggttaatccc 660
atcccacctg ttagggttaa gtggaatggc gaggaatggg aaattaacca aatcagaagt 720
catttcaaat acgtgagtga ctgggcaaag caaaataacg taccaatctt tcttggtgaa 780
ttcggtgctt attcaaaagc agacatggac tcaagggtta agtggaccga aagtgtgaga 840
aaaatggcgg aagaatttgg attttcatac gcgtattggg aattttgtgc aggatttggc 900
atatacgata gatggtctca aaactggatc gaaccattgg caacagctgt ggttggcaca 960
ggcaaagagt aa                                                     972

<210> 15
<211> 323
<212> PRT
<213> Thermotoga sp.

<400> 15
Met Glu Gln Ser Val Ala Glu Ser Asp Ser Asn Ser Ala Phe Glu Tyr
 1               5                  10                  15      
Asn Lys Met Val Gly Lys Gly Val Asn Ile Gly Asn Ala Leu Glu Ala
            20                  25                  30          
Pro Phe Glu Gly Ala Trp Gly Val Arg Ile Glu Asp Glu Tyr Phe Glu
        35                  40                  45              
Ile Ile Lys Lys Arg Gly Phe Asp Ser Val Arg Ile Pro Ile Arg Trp
    50                  55                  60                  
Ser Ala His Ile Ser Glu Lys Pro Pro Tyr Asp Ile Asp Arg Asn Phe
65                  70                  75                  80  
Leu Glu Arg Val Asn His Val Val Asp Arg Ala Leu Glu Asn Asn Leu
                85                  90                  95      
Thr Val Ile Ile Asn Thr His His Phe Glu Glu Leu Tyr Gln Glu Pro
            100                 105                 110         
Asp Lys Tyr Gly Asp Val Leu Val Glu Ile Trp Arg Gln Ile Ala Lys
        115                 120                 125             
Phe Phe Lys Asp Tyr Pro Glu Asn Leu Phe Phe Glu Ile Tyr Asn Glu
    130                 135                 140                 
Pro Ala Gln Asn Leu Thr Ala Glu Lys Trp Asn Ala Leu Tyr Pro Lys
145                 150                 155                 160 
Val Leu Lys Val Ile Arg Glu Ser Asn Pro Thr Arg Ile Val Ile Ile
                165                 170                 175     
Asp Ala Pro Asn Trp Ala His Tyr Ser Ala Val Arg Ser Leu Lys Leu
            180                 185                 190         
Val Asn Asp Lys Arg Ile Ile Val Ser Phe His Tyr Tyr Glu Pro Phe
        195                 200                 205             
Lys Phe Thr His Gln Gly Ala Glu Trp Val Asn Pro Ile Pro Pro Val
    210                 215                 220                 
Arg Val Lys Trp Asn Gly Glu Glu Trp Glu Ile Asn Gln Ile Arg Ser
225                 230                 235                 240 
His Phe Lys Tyr Val Ser Asp Trp Ala Lys Gln Asn Asn Val Pro Ile
                245                 250                 255     
Phe Leu Gly Glu Phe Gly Ala Tyr Ser Lys Ala Asp Met Asp Ser Arg
            260                 265                 270         
Val Lys Trp Thr Glu Ser Val Arg Lys Met Ala Glu Glu Phe Gly Phe
        275                 280                 285             
Ser Tyr Ala Tyr Trp Glu Phe Cys Ala Gly Phe Gly Ile Tyr Asp Arg
    290                 295                 300                 
Trp Ser Gln Asn Trp Ile Glu Pro Leu Ala Thr Ala Val Val Gly Thr
305                 310                 315                 320 
Gly Lys Glu
            


<210> 16
<211> 1042
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated polynucleotide

<400> 16
ggatccacca tgagggtgtt gctcgttgcc ctcgctctcc tggctctcgc tgcgagcgcc 60
accagcggcg tggacccgtt cgagaggaac aagatcctgg gcaggggcat caacatcggc 120
aacgccctgg aggccccgaa cgagggcgac tggggcgtgg tgatcaagga cgagtacttc 180
gacatcatca aggaggccgg cttcagccac gtgagaatcc cgatcaggtg gagcacccac 240
gcccaggcct tcccgccgta caagatcgag gacaggttct tcaagagggt ggacgaggtg 300
atcaacggcg ccctgaagag gggcctggcc gtggtgatca accagcacca ctacgaggag 360
ctgatgaacg acccggagga gcacaaggag aggttcctgg ccctgtggaa gcagatcgcc 420
gacaggtaca aggactaccc ggagaccctg ttcttcgaga tcctgaacga gccgcacggc 480
aacctgaccc cggagaagtg gaacgagctg ctggaggagg ccctgaaggt gatcaggagc 540
atcgacaaga agcacaccat catcatcggc accgccgagt ggggcggcat cagcgccctg 600
gagaagctga gggtgccgaa gtgggagaag aacgccatcg tgaccatcca ctactacaac 660
ccgttcgagt tcacccacca gggcgccgag tgggtggagg gcagcgagaa gtggctgggc 720
aggaagtggg gcagcccgga cgaccagaag cacctgatcg aggagttcaa cttcatcgag 780
gagtggagca agaagaacaa gaggccgatc tacatcggcg agttcggcgc ctacaggaag 840
gccgacctgg agagcaggat caagtggacc agcttcgtgg tgagggaggc cgagaagagg 900
aggtggagct gggcctactg ggagttctgc agcggcttcg gcgtgtacga caccctgagg 960
aagacctgga acaaggacct gctggaggcc ctgatcggcg gcgacagcat cgagagcgag 1020
aaggacgagc tgtgagagct ca                                          1042

<210> 17
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated polypeptide

<400> 17
Met Arg Val Leu Leu Val Ala Leu Ala Leu Leu Ala Leu Ala Ala Ser
 1               5                  10                  15      
Ala Thr Ser Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg
            20                  25                  30          
Gly Ile Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp
        35                  40                  45              
Gly Val Val Ile Lys Asp Glu Tyr Phe Asp Ile Ile Lys Glu Ala Gly
    50                  55                  60                  
Phe Ser His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Gln Ala
65                  70                  75                  80  
Phe Pro Pro Tyr Lys Ile Glu Asp Arg Phe Phe Lys Arg Val Asp Glu
                85                  90                  95      
Val Ile Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Gln
            100                 105                 110         
His His Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg
        115                 120                 125             
Phe Leu Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro
    130                 135                 140                 
Glu Thr Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr
145                 150                 155                 160 
Pro Glu Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg
                165                 170                 175     
Ser Ile Asp Lys Lys His Thr Ile Ile Ile Gly Thr Ala Glu Trp Gly
            180                 185                 190         
Gly Ile Ser Ala Leu Glu Lys Leu Arg Val Pro Lys Trp Glu Lys Asn
        195                 200                 205             
Ala Ile Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln
    210                 215                 220                 
Gly Ala Glu Trp Val Glu Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp
225                 230                 235                 240 
Gly Ser Pro Asp Asp Gln Lys His Leu Ile Glu Glu Phe Asn Phe Ile
                245                 250                 255     
Glu Glu Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe
            260                 265                 270         
Gly Ala Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser
        275                 280                 285             
Phe Val Val Arg Glu Ala Glu Lys Arg Arg Trp Ser Trp Ala Tyr Trp
    290                 295                 300                 
Glu Phe Cys Ser Gly Phe Gly Val Tyr Asp Thr Leu Arg Lys Thr Trp
305                 310                 315                 320 
Asn Lys Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu Ser
                325                 330                 335     
Glu Lys Asp Glu Leu
            340     


<210> 18
<211> 1042
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated polynucleotide

<400> 18
ggatccacca tgagggtgtt gctcgttgcc ctcgctctcc tggctctcgc tgcgagcgcc 60
accagcggcg tggacccgtt cgagaggaac aagatcctgg gcaggggcat caacatcggc 120
aacgccctgg aggccccgaa cgagggcgac tggggcgtgg tgatcaagga cgagttcttc 180
gacatcatca aggaggccgg cttcagccac gtgagaatcc cgatcaggtg gagcacccac 240
gcccaggcct tcccgccgta caagatcgag ccgagcttct tcaagagggt ggacgaggtg 300
atcaacggcg ccctgaagag gggcctggcc gtggtgatca acatccacca ctacgaggag 360
ctgatgaacg acccggagga gcacaaggag aggttcctgg ccctgtggaa gcagatcgcc 420
gacaggtaca aggactaccc ggagaccctg ttcttcgaga tcctgaacga gccgcacggc 480
aacctgaccc cggagaagtg gaacgagctg ctggaggagg ccctgaaggt gatcaggagc 540
atcgacaaga agcacaccgt gatcatcggc accgccgagt ggggcggcat cagcgccctg 600
gagaagctga gggtgccgaa gtgggagaag aacgccatcg tgaccatcca ctactacaac 660
ccgttcgagt tcacccacca gggcgccgag tgggtgccgg gcagcgagaa gtggctgggc 720
aggaagtggg gcagcccgga cgaccagaag cacctgatcg aggagttcaa cttcatcgag 780
gagtggagca agaagaacaa gaggccgatc tacatcggcg agttcggcgc ctacaggaag 840
gccgacctgg agagcaggat caagtggacc agcttcgtgg tgagggaggc cgagaagagg 900
ggctggagct gggcctactg ggagttctgc agcggcttcg gcgtgtacga cccgctgagg 960
aagcagtgga acaaggacct gctggaggcc ctgatcggcg gcgacagcat cgagagcgag 1020
aaggacgagc tgtgagagct ca                                          1042

<210> 19
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated polypeptide

<400> 19
Met Arg Val Leu Leu Val Ala Leu Ala Leu Leu Ala Leu Ala Ala Ser
 1               5                  10                  15      
Ala Thr Ser Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg
            20                  25                  30          
Gly Ile Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp
        35                  40                  45              
Gly Val Val Ile Lys Asp Glu Phe Phe Asp Ile Ile Lys Glu Ala Gly
    50                  55                  60                  
Phe Ser His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Gln Ala
65                  70                  75                  80  
Phe Pro Pro Tyr Lys Ile Glu Pro Ser Phe Phe Lys Arg Val Asp Glu
                85                  90                  95      
Val Ile Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Ile
            100                 105                 110         
His His Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg
        115                 120                 125             
Phe Leu Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro
    130                 135                 140                 
Glu Thr Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr
145                 150                 155                 160 
Pro Glu Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg
                165                 170                 175     
Ser Ile Asp Lys Lys His Thr Val Ile Ile Gly Thr Ala Glu Trp Gly
            180                 185                 190         
Gly Ile Ser Ala Leu Glu Lys Leu Arg Val Pro Lys Trp Glu Lys Asn
        195                 200                 205             
Ala Ile Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln
    210                 215                 220                 
Gly Ala Glu Trp Val Pro Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp
225                 230                 235                 240 
Gly Ser Pro Asp Asp Gln Lys His Leu Ile Glu Glu Phe Asn Phe Ile
                245                 250                 255     
Glu Glu Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe
            260                 265                 270         
Gly Ala Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser
        275                 280                 285             
Phe Val Val Arg Glu Ala Glu Lys Arg Gly Trp Ser Trp Ala Tyr Trp
    290                 295                 300                 
Glu Phe Cys Ser Gly Phe Gly Val Tyr Asp Pro Leu Arg Lys Gln Trp
305                 310                 315                 320 
Asn Lys Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu Ser
                325                 330                 335     
Glu Lys Asp Glu Leu
            340     


<210> 20
<211> 1042
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated polynucleotide

<400> 20
ggatccacca tgagggtgtt gctcgttgcc ctcgctctcc tggctctcgc tgcgagcgcc 60
accagcggcg tggacccgtt cgagaggaac aagatcctgg gcaggggcat caacatcggc 120
aacgccctgg aggccccgaa cgagggcgac tggggcgtgg tgatcaagga cgagtacttc 180
gacatcatca aggaggccgg cttcagccac gtgagaatcc cgatcaggtg gagcacccac 240
gcccaggcct tcccgccgta caagatcgag gacagcttct tcaagagggt ggacgaggtg 300
atcaacggcg ccctgaagag gggcctggcc gtggtgatca acatccacca ctacgaggag 360
ctgatgaacg acccggagga gcacaaggag aggttcctgg ccctgtggaa gcagatcgcc 420
gacaggtaca aggactaccc ggagaccctg ttcttcgaga tcctgaacga gccgcacggc 480
aacctgaccc cggagaagtg gaacgagctg ctggaggagg ccctgaaggt gatcaggagc 540
atcgacaaga agcacaccgt gatcatcggc accgccgagt ggggcggcat cagcgccctg 600
gagaagctga gggtgccgaa gtgggagaag aacgccatcg tgaccatcca ctactacaac 660
ccgttcgagt tcacccacca gggcgccgag tgggtgccgg gcagcgagaa gtggctgggc 720
aggaagtggg gcagcccgga cgaccagaag cacgtgatcg aggagttcaa cttcatcgag 780
gagtggagca agaagaacaa gaggccgatc tacatcggcg agttcggcgc ctacaggaag 840
gccgacctgg agagcaggat caagtggacc agcttcgtgg tgagggaggc cgagaagagg 900
ggctggagct gggcctactg ggagttctgc agcggcttcg gcgtgtacga cccgctgagg 960
aagcagtgga acaaggacct gctggaggcc ctgatcggcg gcgacagcat cgagagcgag 1020
aaggacgagc tgtgagagct ca                                          1042

<210> 21
<211> 341
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated polypeptide

<400> 21
Met Arg Val Leu Leu Val Ala Leu Ala Leu Leu Ala Leu Ala Ala Ser
 1               5                  10                  15      
Ala Thr Ser Gly Val Asp Pro Phe Glu Arg Asn Lys Ile Leu Gly Arg
            20                  25                  30          
Gly Ile Asn Ile Gly Asn Ala Leu Glu Ala Pro Asn Glu Gly Asp Trp
        35                  40                  45              
Gly Val Val Ile Lys Asp Glu Tyr Phe Asp Ile Ile Lys Glu Ala Gly
    50                  55                  60                  
Phe Ser His Val Arg Ile Pro Ile Arg Trp Ser Thr His Ala Gln Ala
65                  70                  75                  80  
Phe Pro Pro Tyr Lys Ile Glu Asp Ser Phe Phe Lys Arg Val Asp Glu
                85                  90                  95      
Val Ile Asn Gly Ala Leu Lys Arg Gly Leu Ala Val Val Ile Asn Ile
            100                 105                 110         
His His Tyr Glu Glu Leu Met Asn Asp Pro Glu Glu His Lys Glu Arg
        115                 120                 125             
Phe Leu Ala Leu Trp Lys Gln Ile Ala Asp Arg Tyr Lys Asp Tyr Pro
    130                 135                 140                 
Glu Thr Leu Phe Phe Glu Ile Leu Asn Glu Pro His Gly Asn Leu Thr
145                 150                 155                 160 
Pro Glu Lys Trp Asn Glu Leu Leu Glu Glu Ala Leu Lys Val Ile Arg
                165                 170                 175     
Ser Ile Asp Lys Lys His Thr Val Ile Ile Gly Thr Ala Glu Trp Gly
            180                 185                 190         
Gly Ile Ser Ala Leu Glu Lys Leu Arg Val Pro Lys Trp Glu Lys Asn
        195                 200                 205             
Ala Ile Val Thr Ile His Tyr Tyr Asn Pro Phe Glu Phe Thr His Gln
    210                 215                 220                 
Gly Ala Glu Trp Val Pro Gly Ser Glu Lys Trp Leu Gly Arg Lys Trp
225                 230                 235                 240 
Gly Ser Pro Asp Asp Gln Lys His Val Ile Glu Glu Phe Asn Phe Ile
                245                 250                 255     
Glu Glu Trp Ser Lys Lys Asn Lys Arg Pro Ile Tyr Ile Gly Glu Phe
            260                 265                 270         
Gly Ala Tyr Arg Lys Ala Asp Leu Glu Ser Arg Ile Lys Trp Thr Ser
        275                 280                 285             
Phe Val Val Arg Glu Ala Glu Lys Arg Gly Trp Ser Trp Ala Tyr Trp
    290                 295                 300                 
Glu Phe Cys Ser Gly Phe Gly Val Tyr Asp Pro Leu Arg Lys Gln Trp
305                 310                 315                 320 
Asn Lys Asp Leu Leu Glu Ala Leu Ile Gly Gly Asp Ser Ile Glu Ser
                325                 330                 335     
Glu Lys Asp Glu Leu
            340     

