                         SEQUENCE LISTING

<110>  Bayer Pharma AG
 
<120>  Modulators of SLC22A13

<130>  BHC 13 1 012

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  1
atggctcagt ttgtccaggt cctggctgaa ataggtgact ttggtcgctt ccagatacag       60

ctattgatcc tgctgtgtgt tctcaacttc ctgtctccct tctacttttt tgcccatgtc      120

ttcatggtcc tagatgagcc ccaccactgt gcagtggctt gggtgaagaa ccacactttc      180

aacctgagtg ctgctgaaca gctggtactg agcgtgcccc tggacactgc aggtcaccca      240

gagccctgcc tcatgttccg gccacccccc gccaatgcca gcctgcagga catcctcagc      300

caccgcttca atgagacgca gccttgtgat atgggctggg aatatcctga gaacaggctc      360

ccatccctga agaatgagtt caacctggtt tgtgatcgga agcacctgaa ggacaccaca      420

cagtcagtgt tcatggctgg gctccttgtt ggcaccctca tgtttgggcc cctctgcgac      480

cggattggcc gcaaggccac aatcctggcg cagctgctcc tcttcaccct catcggcctg      540

gccacagctt ttgtgcccag ctttgagctc tacatggccc tgcgctttgc tgtggctact      600

gccgtcgctg gacttagctt cagcaatgtc accctactga cagaatgggt ggggccctca      660

tggaggacgc aggccgtggt cctggcccag tgcaacttct ccctcgggca gatggtgctt      720

gcgggactcg cctacggttt ccgcaactgg aggctccttc agatcaccgg cactgcgcct      780

ggcttactgc tcttcttcta cttctgggct ctgccagaat ctgcacgttg gctcctgacc      840

cgtgggagga tggacgaggc gatacaactg atccagaagg cggcctcggt caataggcgg      900

aaactctccc cggagctcat gaaccagctg gtcccagaga agacaggccc ctcagggaat      960

gccctggatc tgttcagaca cccccagctc cggaaggtga ccctgattat cttctgtgtc     1020

tggtttgtgg acagtctggg gtactacggc ctgagcctcc aagtggggga cttcggcctg     1080

gacgtctatc tgacgcagct catctttgga gctgttgagg tgcctgcccg ctgttccagc     1140

atcttcatga tgcagaggtt tggccgcaag tggagccagt tggggacctt ggtcttgggt     1200

ggcctgatgt gtatcatcat catcttcatc ccagcagatc tgcccgtggt ggtcaccatg     1260

ctggctgtgg tggggaagat ggccacagct gctgccttta ccatctccta tgtgtactct     1320

gccgagcttt tccccaccat cctccggcag acaggcatgg ggctggtggg catcttctca     1380

cggatcgggg gcatcctcac accacttgtg atcctgctgg gagagtacca cgctgccctc     1440

cccatgctca tctacggcag cctccccatc gtggccggcc tgctgtgcac cctgctgcca     1500

gagacgcatg gccagggcct gaaagacacc ctccaggacc tggagctggg gcctcaccca     1560

cggtccccca aatcagtgcc ctcagagaag gaaacagagg ccaagggaag aacttccagc     1620

ccgggagtgg cctttgtgag cagcacatac ttctga                               1656


<210>  2
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Phe Val Gln Val Leu Ala Glu Ile Gly Asp Phe Gly Arg 
1               5                   10                  15      


Phe Gln Ile Gln Leu Leu Ile Leu Leu Cys Val Leu Asn Phe Leu Ser 
            20                  25                  30          


Pro Phe Tyr Phe Phe Ala His Val Phe Met Val Leu Asp Glu Pro His 
        35                  40                  45              


His Cys Ala Val Ala Trp Val Lys Asn His Thr Phe Asn Leu Ser Ala 
    50                  55                  60                  


Ala Glu Gln Leu Val Leu Ser Val Pro Leu Asp Thr Ala Gly His Pro 
65                  70                  75                  80  


Glu Pro Cys Leu Met Phe Arg Pro Pro Pro Ala Asn Ala Ser Leu Gln 
                85                  90                  95      


Asp Ile Leu Ser His Arg Phe Asn Glu Thr Gln Pro Cys Asp Met Gly 
            100                 105                 110         


Trp Glu Tyr Pro Glu Asn Arg Leu Pro Ser Leu Lys Asn Glu Phe Asn 
        115                 120                 125             


Leu Val Cys Asp Arg Lys His Leu Lys Asp Thr Thr Gln Ser Val Phe 
    130                 135                 140                 


Met Gly Gly Leu Leu Val Gly Thr Leu Met Phe Gly Pro Leu Cys Asp 
145                 150                 155                 160 


Arg Ile Gly Arg Lys Ala Thr Ile Leu Ala Gln Leu Leu Leu Phe Thr 
                165                 170                 175     


Leu Ile Gly Leu Ala Thr Ala Phe Val Pro Ser Phe Glu Leu Tyr Met 
            180                 185                 190         


Ala Leu Arg Phe Ala Val Ala Thr Ala Val Ala Gly Leu Ser Phe Ser 
        195                 200                 205             


Asn Val Thr Leu Leu Thr Glu Trp Val Gly Pro Ser Trp Arg Thr Gln 
    210                 215                 220                 


Ala Val Val Leu Ala Gln Cys Asn Phe Ser Leu Gly Gln Met Val Leu 
225                 230                 235                 240 


Ala Gly Leu Ala Tyr Gly Phe Arg Asn Trp Arg Leu Leu Gln Ile Thr 
                245                 250                 255     


Gly Thr Ala Pro Gly Leu Leu Leu Phe Phe Tyr Phe Trp Ala Leu Pro 
            260                 265                 270         


Glu Ser Ala Arg Trp Leu Leu Thr Arg Gly Arg Met Asp Glu Ala Ile 
        275                 280                 285             


Gln Leu Ile Gln Lys Ala Ala Ser Val Asn Arg Arg Lys Leu Ser Pro 
    290                 295                 300                 


Glu Leu Met Asn Gln Leu Val Pro Glu Lys Thr Gly Pro Ser Gly Asn 
305                 310                 315                 320 


Ala Leu Asp Leu Phe Arg His Pro Gln Leu Arg Lys Val Thr Leu Ile 
                325                 330                 335     


Ile Phe Cys Val Trp Phe Val Asp Ser Leu Gly Tyr Tyr Gly Leu Ser 
            340                 345                 350         


Leu Gln Val Gly Asp Phe Gly Leu Asp Val Tyr Leu Thr Gln Leu Ile 
        355                 360                 365             


Phe Gly Ala Val Glu Val Pro Ala Arg Cys Ser Ser Ile Phe Met Met 
    370                 375                 380                 


Gln Arg Phe Gly Arg Lys Trp Ser Gln Leu Gly Thr Leu Val Leu Gly 
385                 390                 395                 400 


Gly Leu Met Cys Ile Ile Ile Ile Phe Ile Pro Ala Asp Leu Pro Val 
                405                 410                 415     


Val Val Thr Met Leu Ala Val Val Gly Lys Met Ala Thr Ala Ala Ala 
            420                 425                 430         


Phe Thr Ile Ser Tyr Val Tyr Ser Ala Glu Leu Phe Pro Thr Ile Leu 
        435                 440                 445             


Arg Gln Thr Gly Met Gly Leu Val Gly Ile Phe Ser Arg Ile Gly Gly 
    450                 455                 460                 


Ile Leu Thr Pro Leu Val Ile Leu Leu Gly Glu Tyr His Ala Ala Leu 
465                 470                 475                 480 


Pro Met Leu Ile Tyr Gly Ser Leu Pro Ile Val Ala Gly Leu Leu Cys 
                485                 490                 495     


Thr Leu Leu Pro Glu Thr His Gly Gln Gly Leu Lys Asp Thr Leu Gln 
            500                 505                 510         


Asp Leu Glu Leu Gly Pro His Pro Arg Ser Pro Lys Ser Val Pro Ser 
        515                 520                 525             


Glu Lys Glu Thr Glu Ala Lys Gly Arg Thr Ser Ser Pro Gly Val Ala 
    530                 535                 540                 


Phe Val Ser Ser Thr Tyr Phe 
545                 550     


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  3
gcctggctta ctgctcttct t                                                 21


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  4
tgtatcgcct cgtccatcc                                                    19


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  5
tgggctctgc cagaatctgc                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
aagttcatcc ggcaccagtc                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
tggcccttga atcttctacg a                                                 21


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  8
cccagaggca ttgacaacag gg                                                22


