                         SEQUENCE LISTING

<110>  Athenix Corp.
       Thayer, Rebecca
       Sampson, Kimberly
       Lehtinen, Duane
       Magalhaes, Leonardo
 
<120>  AXMI440 TOXIN GENE AND METHODS FOR ITS USE

<130>  APA13-6051

<150>  61/863,982
<151>  2013-08-09

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  4299
<212>  DNA
<213>  Bacillus thuringiensis

<400>  1
atgaaaaaag ataatgaaat aagcaattac gttaatgata accatgtgaa ttcccataag       60

aaagttcctt tttgttgtgt catagcaatt ccagatggat ttgaactcgt accacattgt      120

tatccaaaag taatatacag tcttgagtgt ctagccctat gtaaagatgt atgtcgcaaa      180

accgtgccag tagaagggtg tggtcaggca gaaattgatt tacatgttct aaagataaag      240

ggatgcattc cttatatagt caatattgaa gtacgaccta catgtgattg gaaaggatgt      300

tcaacagact cacattcaaa agaaatcaca ttatgttgta aagagagtgt atgtattgat      360

gcagttttac aatgtagtgt gcactgtgta gacagcatag atttaaactg tgaaaatgta      420

aaggtatgtg acttaagcat acaaatttct gattgtatga attcctgtca tcttgctaaa      480

atctccggtt actttcagtt ttgctagaat aaaataaaga taatttagag ttataagtct      540

aacaataaat gaatattata aaatgtctta aggaacaatg ttccttgtag atactttaaa      600

aaataagaag ggacgattaa ataccagaat atggaggggg gagaggggct tttcgtactg      660

atattaaaga atgaatttat atatataagt acaagtggaa aatcattgat aatgcgagta      720

tatccttgaa atgtataaat aggaggtata gatgtgaaga taaatgatgt aaatgaatgg      780

gataatgtag cagaggtgac tgaaaaccct cttgcaccta gcattccgta caatgttcta      840

caacgtaaag aaaacacagc aaacgaatta acctatgata attataattt ccaagatttt      900

ttaacattag gttatgaaga tattactcaa gcagctaatg cgcaagatgt aattaatacg      960

acactaaatg taactgcaac aattttgaat ttcttaggag tcccgtatgc agggactgta     1020

atttctatgt atcaaaaact atttaattat ttatggcctt atgaagacac ttcagaatgg     1080

gataaaatga tggcggcagt agaagcgcta ataaatcaaa aaatcaatga gacagttaaa     1140

agtttggctc ttgcggattt agatggttta gggcgcaact taaagtctta tggaaatgca     1200

cttaagaatt ggaatgagaa taaaaatgat gcagatagca cagctttagt gttagatcgc     1260

tttagaacag ttaatgaact atttgtaaat gatatggctt cttttgctcc taaaggttac     1320

gaggtactac ttctggacgt atatgcaaaa gcagcaaatc tacatttgct ttttttaaga     1380

gatgcagaac tatatggtgc agattgggga atgcctgaag atgagataaa tttattttat     1440

caagaacaag aagattatag aaaagaatat tcggaccatt gcatatcttg gtatcaaaaa     1500

gggttaaatc agtttaataa gtctagtgca ctggattgga taaaatataa tcgttacaga     1560

acccaaatga caattaatgt gttggatttt gttgcgttat atccaaatta tgatgttcgt     1620

aaatatccaa tgtccacaca cacggagctt acaagaactg tatattcaga tcctattggt     1680

tttgatgaac gaacgggaac tggtactagt ggggttcgtg cttggtatga agctggacgc     1740

tcttttgctg agatagaaaa taatgctatt cctgcacctg atatcgttaa atttataaat     1800

aaactaacag tatattcaaa aaggataaat gccagtccat tcatggccac tcgttgggca     1860

gggcattcca taactcagga cactacattt acaggttcag cacaagaaat aaagtatgga     1920

gatgtttcag gtgtccctac cacattttta tttaaaaaca cagatattta tcgtacgata     1980

tcaacggtag gaacgtatta ttatactaat ggcccttata aactgccact ttcaaaagtt     2040

catttttatg gaataaatac ttctaatcga aaggaaactt tcaattatga tcaagatatt     2100

aattttaaat ttcagcatca aaaagactca agtaatgaga tagctgtagt ccttccagga     2160

cccacagact atggggacta taataaatat agtcatcggt taagttatat ttctgatgcc     2220

cctataaaac agttcactgg gttaagctca aatgaaggtt ttgtccctgt atttggttgg     2280

atgcattcaa gcacaactcg taaaaatttt cttagtgcca atcaaatcac gcaaattcca     2340

gctgtaaagt ctcacgaata taactcatcc atggcaattg taagctcaaa cggatattgt     2400

ggcggatata ttatgaaggt ttcaaaagta tttccattca atgaagtgac agctggaaac     2460

tatgtagtag attgtgaaga ttatagtcaa caatttcgtt ttcgggttag atatgcttcc     2520

actgtaagct gtccactacg gtttgctaca ttcagcatat ctggtccaac cgttaattta     2580

gaaaaaacac tacaaaaagg tgatgaaata aaatatagtt cctttaaata ttctgaatac     2640

tcagatcctg tgaggtttaa ccctcctggt acctcaggat tccctagttt taatcttata     2700

tttgtaggat tatctgctaa tgaaaatgta tatatagata aaattgaatg tattccagtc     2760

acaaaagatg atttagacaa ggaaacatta gaaaaagcag aaaaagcggt gaatgctttg     2820

tttattgatg gtacccagaa tttaaaaaca gaagtgacag attattgtat agatcaggtt     2880

tctatgataa tagattgtgt gtctgaagaa ctatatccaa atgaaaaacg agatcttttg     2940

tatttagtaa agcatgcgaa aagacaaagt aatacacgaa acttaattct ggattccaac     3000

tttacttcta ttaattcaga agatgttaac ggttggtatg gaagtcctgg tcttatagta     3060

gaatctggag atgtggtctt taaagaaaat tatgtacatt tacgtggtcc aaatgatgaa     3120

cgctatccaa cgtacctgta tcaaaaaata gacgaatcaa aattaacaga atatacaaga     3180

tatcaattgc gaggtttcat agaaggaagt cgtggtttgg aagtatatgt aattcgttat     3240

gatgcaaaac atgaaacact gaatgtttta ggggatttat ctctagataa tctgtcttac     3300

aacgaatgtg gtcaaccaga tcgctgttca caagaaccat atattgaaca gaggttacaa     3360

caagaagaag ttgctaatga acgtgcatgt cattttgatt ccaatgactc cctgtcttca     3420

tcaaatggat atccttctga ttcacatcat ttatccctac acgttgatac cggatctatt     3480

gattttaaag aaaatttagg tatctggatt ttattcaaat tatcgacaac agatggatat     3540

gcaaagattg ggaatattga attggtggaa gagggaccat taacaggaag tgcgctcgga     3600

tctataaaaa gaatggaaaa taaatggaaa gaaaaagtgg agagcattcg tttacaaggg     3660

aaaaaagcat atgatacagc aaaactatat attgataatc tatttgaagg ctctcaaaat     3720

acaaagttgt atccttttgt cacattttta acactatcca atgctcgaca acttataaat     3780

aagatttata acaaatatag tccttggtta tcattaattc ctggagtgaa ttatgattta     3840

tttgaagaat tagccgtcag atttcaaaat gctttacaat tatatgatac aagaaacttg     3900

atacaaaatg ggcgatttat tgacggttta gtgagttgga tgacaacacc aggtgtacaa     3960

gtgcgaaaag atagtgcatc ctccatactt gagttaaata gttgggaaga acaagtggta     4020

caaaaagtac cagtgtgcca agggtatggg tatgtattac gtgtaacagc aagtaaagaa     4080

gatttaggag agggatatat taaggttagt gatgaaatgg gtaatagtga tactataata     4140

tttagtgcat gtaataattc aaataatgac gtctctataa ataattatgt tacacaagag     4200

ttagagttct tccctgattc agattacgtt caccttgaaa ttggggaaac agaaggaaca     4260

tttcagattg taagtgttga gctaatttta atggaagat                            4299


<210>  2
<211>  3546
<212>  DNA
<213>  Bacillus thuringiensis

<400>  2
gtgaagataa atgatgtaaa tgaatgggat aatgtagcag aggtgactga aaaccctctt       60

gcacctagca ttccgtacaa tgttctacaa cgtaaagaaa acacagcaaa cgaattaacc      120

tatgataatt ataatttcca agatttttta acattaggtt atgaagatat tactcaagca      180

gctaatgcgc aagatgtaat taatacgaca ctaaatgtaa ctgcaacaat tttgaatttc      240

ttaggagtcc cgtatgcagg gactgtaatt tctatgtatc aaaaactatt taattattta      300

tggccttatg aagacacttc agaatgggat aaaatgatgg cggcagtaga agcgctaata      360

aatcaaaaaa tcaatgagac agttaaaagt ttggctcttg cggatttaga tggtttaggg      420

cgcaacttaa agtcttatgg aaatgcactt aagaattgga atgagaataa aaatgatgca      480

gatagcacag ctttagtgtt agatcgcttt agaacagtta atgaactatt tgtaaatgat      540

atggcttctt ttgctcctaa aggttacgag gtactacttc tggacgtata tgcaaaagca      600

gcaaatctac atttgctttt tttaagagat gcagaactat atggtgcaga ttggggaatg      660

cctgaagatg agataaattt attttatcaa gaacaagaag attatagaaa agaatattcg      720

gaccattgca tatcttggta tcaaaaaggg ttaaatcagt ttaataagtc tagtgcactg      780

gattggataa aatataatcg ttacagaacc caaatgacaa ttaatgtgtt ggattttgtt      840

gcgttatatc caaattatga tgttcgtaaa tatccaatgt ccacacacac ggagcttaca      900

agaactgtat attcagatcc tattggtttt gatgaacgaa cgggaactgg tactagtggg      960

gttcgtgctt ggtatgaagc tggacgctct tttgctgaga tagaaaataa tgctattcct     1020

gcacctgata tcgttaaatt tataaataaa ctaacagtat attcaaaaag gataaatgcc     1080

agtccattca tggccactcg ttgggcaggg cattccataa ctcaggacac tacatttaca     1140

ggttcagcac aagaaataaa gtatggagat gtttcaggtg tccctaccac atttttattt     1200

aaaaacacag atatttatcg tacgatatca acggtaggaa cgtattatta tactaatggc     1260

ccttataaac tgccactttc aaaagttcat ttttatggaa taaatacttc taatcgaaag     1320

gaaactttca attatgatca agatattaat tttaaatttc agcatcaaaa agactcaagt     1380

aatgagatag ctgtagtcct tccaggaccc acagactatg gggactataa taaatatagt     1440

catcggttaa gttatatttc tgatgcccct ataaaacagt tcactgggtt aagctcaaat     1500

gaaggttttg tccctgtatt tggttggatg cattcaagca caactcgtaa aaattttctt     1560

agtgccaatc aaatcacgca aattccagct gtaaagtctc acgaatataa ctcatccatg     1620

gcaattgtaa gctcaaacgg atattgtggc ggatatatta tgaaggtttc aaaagtattt     1680

ccattcaatg aagtgacagc tggaaactat gtagtagatt gtgaagatta tagtcaacaa     1740

tttcgttttc gggttagata tgcttccact gtaagctgtc cactacggtt tgctacattc     1800

agcatatctg gtccaaccgt taatttagaa aaaacactac aaaaaggtga tgaaataaaa     1860

tatagttcct ttaaatattc tgaatactca gatcctgtga ggtttaaccc tcctggtacc     1920

tcaggattcc ctagttttaa tcttatattt gtaggattat ctgctaatga aaatgtatat     1980

atagataaaa ttgaatgtat tccagtcaca aaagatgatt tagacaagga aacattagaa     2040

aaagcagaaa aagcggtgaa tgctttgttt attgatggta cccagaattt aaaaacagaa     2100

gtgacagatt attgtataga tcaggtttct atgataatag attgtgtgtc tgaagaacta     2160

tatccaaatg aaaaacgaga tcttttgtat ttagtaaagc atgcgaaaag acaaagtaat     2220

acacgaaact taattctgga ttccaacttt acttctatta attcagaaga tgttaacggt     2280

tggtatggaa gtcctggtct tatagtagaa tctggagatg tggtctttaa agaaaattat     2340

gtacatttac gtggtccaaa tgatgaacgc tatccaacgt acctgtatca aaaaatagac     2400

gaatcaaaat taacagaata tacaagatat caattgcgag gtttcataga aggaagtcgt     2460

ggtttggaag tatatgtaat tcgttatgat gcaaaacatg aaacactgaa tgttttaggg     2520

gatttatctc tagataatct gtcttacaac gaatgtggtc aaccagatcg ctgttcacaa     2580

gaaccatata ttgaacagag gttacaacaa gaagaagttg ctaatgaacg tgcatgtcat     2640

tttgattcca atgactccct gtcttcatca aatggatatc cttctgattc acatcattta     2700

tccctacacg ttgataccgg atctattgat tttaaagaaa atttaggtat ctggatttta     2760

ttcaaattat cgacaacaga tggatatgca aagattggga atattgaatt ggtggaagag     2820

ggaccattaa caggaagtgc gctcggatct ataaaaagaa tggaaaataa atggaaagaa     2880

aaagtggaga gcattcgttt acaagggaaa aaagcatatg atacagcaaa actatatatt     2940

gataatctat ttgaaggctc tcaaaataca aagttgtatc cttttgtcac atttttaaca     3000

ctatccaatg ctcgacaact tataaataag atttataaca aatatagtcc ttggttatca     3060

ttaattcctg gagtgaatta tgatttattt gaagaattag ccgtcagatt tcaaaatgct     3120

ttacaattat atgatacaag aaacttgata caaaatgggc gatttattga cggtttagtg     3180

agttggatga caacaccagg tgtacaagtg cgaaaagata gtgcatcctc catacttgag     3240

ttaaatagtt gggaagaaca agtggtacaa aaagtaccag tgtgccaagg gtatgggtat     3300

gtattacgtg taacagcaag taaagaagat ttaggagagg gatatattaa ggttagtgat     3360

gaaatgggta atagtgatac tataatattt agtgcatgta ataattcaaa taatgacgtc     3420

tctataaata attatgttac acaagagtta gagttcttcc ctgattcaga ttacgttcac     3480

cttgaaattg gggaaacaga aggaacattt cagattgtaa gtgttgagct aattttaatg     3540

gaagat                                                                3546


<210>  3
<211>  1182
<212>  PRT
<213>  Bacillus thuringiensis

<400>  3

Met Lys Ile Asn Asp Val Asn Glu Trp Asp Asn Val Ala Glu Val Thr 
1               5                   10                  15      


Glu Asn Pro Leu Ala Pro Ser Ile Pro Tyr Asn Val Leu Gln Arg Lys 
            20                  25                  30          


Glu Asn Thr Ala Asn Glu Leu Thr Tyr Asp Asn Tyr Asn Phe Gln Asp 
        35                  40                  45              


Phe Leu Thr Leu Gly Tyr Glu Asp Ile Thr Gln Ala Ala Asn Ala Gln 
    50                  55                  60                  


Asp Val Ile Asn Thr Thr Leu Asn Val Thr Ala Thr Ile Leu Asn Phe 
65                  70                  75                  80  


Leu Gly Val Pro Tyr Ala Gly Thr Val Ile Ser Met Tyr Gln Lys Leu 
                85                  90                  95      


Phe Asn Tyr Leu Trp Pro Tyr Glu Asp Thr Ser Glu Trp Asp Lys Met 
            100                 105                 110         


Met Ala Ala Val Glu Ala Leu Ile Asn Gln Lys Ile Asn Glu Thr Val 
        115                 120                 125             


Lys Ser Leu Ala Leu Ala Asp Leu Asp Gly Leu Gly Arg Asn Leu Lys 
    130                 135                 140                 


Ser Tyr Gly Asn Ala Leu Lys Asn Trp Asn Glu Asn Lys Asn Asp Ala 
145                 150                 155                 160 


Asp Ser Thr Ala Leu Val Leu Asp Arg Phe Arg Thr Val Asn Glu Leu 
                165                 170                 175     


Phe Val Asn Asp Met Ala Ser Phe Ala Pro Lys Gly Tyr Glu Val Leu 
            180                 185                 190         


Leu Leu Asp Val Tyr Ala Lys Ala Ala Asn Leu His Leu Leu Phe Leu 
        195                 200                 205             


Arg Asp Ala Glu Leu Tyr Gly Ala Asp Trp Gly Met Pro Glu Asp Glu 
    210                 215                 220                 


Ile Asn Leu Phe Tyr Gln Glu Gln Glu Asp Tyr Arg Lys Glu Tyr Ser 
225                 230                 235                 240 


Asp His Cys Ile Ser Trp Tyr Gln Lys Gly Leu Asn Gln Phe Asn Lys 
                245                 250                 255     


Ser Ser Ala Leu Asp Trp Ile Lys Tyr Asn Arg Tyr Arg Thr Gln Met 
            260                 265                 270         


Thr Ile Asn Val Leu Asp Phe Val Ala Leu Tyr Pro Asn Tyr Asp Val 
        275                 280                 285             


Arg Lys Tyr Pro Met Ser Thr His Thr Glu Leu Thr Arg Thr Val Tyr 
    290                 295                 300                 


Ser Asp Pro Ile Gly Phe Asp Glu Arg Thr Gly Thr Gly Thr Ser Gly 
305                 310                 315                 320 


Val Arg Ala Trp Tyr Glu Ala Gly Arg Ser Phe Ala Glu Ile Glu Asn 
                325                 330                 335     


Asn Ala Ile Pro Ala Pro Asp Ile Val Lys Phe Ile Asn Lys Leu Thr 
            340                 345                 350         


Val Tyr Ser Lys Arg Ile Asn Ala Ser Pro Phe Met Ala Thr Arg Trp 
        355                 360                 365             


Ala Gly His Ser Ile Thr Gln Asp Thr Thr Phe Thr Gly Ser Ala Gln 
    370                 375                 380                 


Glu Ile Lys Tyr Gly Asp Val Ser Gly Val Pro Thr Thr Phe Leu Phe 
385                 390                 395                 400 


Lys Asn Thr Asp Ile Tyr Arg Thr Ile Ser Thr Val Gly Thr Tyr Tyr 
                405                 410                 415     


Tyr Thr Asn Gly Pro Tyr Lys Leu Pro Leu Ser Lys Val His Phe Tyr 
            420                 425                 430         


Gly Ile Asn Thr Ser Asn Arg Lys Glu Thr Phe Asn Tyr Asp Gln Asp 
        435                 440                 445             


Ile Asn Phe Lys Phe Gln His Gln Lys Asp Ser Ser Asn Glu Ile Ala 
    450                 455                 460                 


Val Val Leu Pro Gly Pro Thr Asp Tyr Gly Asp Tyr Asn Lys Tyr Ser 
465                 470                 475                 480 


His Arg Leu Ser Tyr Ile Ser Asp Ala Pro Ile Lys Gln Phe Thr Gly 
                485                 490                 495     


Leu Ser Ser Asn Glu Gly Phe Val Pro Val Phe Gly Trp Met His Ser 
            500                 505                 510         


Ser Thr Thr Arg Lys Asn Phe Leu Ser Ala Asn Gln Ile Thr Gln Ile 
        515                 520                 525             


Pro Ala Val Lys Ser His Glu Tyr Asn Ser Ser Met Ala Ile Val Ser 
    530                 535                 540                 


Ser Asn Gly Tyr Cys Gly Gly Tyr Ile Met Lys Val Ser Lys Val Phe 
545                 550                 555                 560 


Pro Phe Asn Glu Val Thr Ala Gly Asn Tyr Val Val Asp Cys Glu Asp 
                565                 570                 575     


Tyr Ser Gln Gln Phe Arg Phe Arg Val Arg Tyr Ala Ser Thr Val Ser 
            580                 585                 590         


Cys Pro Leu Arg Phe Ala Thr Phe Ser Ile Ser Gly Pro Thr Val Asn 
        595                 600                 605             


Leu Glu Lys Thr Leu Gln Lys Gly Asp Glu Ile Lys Tyr Ser Ser Phe 
    610                 615                 620                 


Lys Tyr Ser Glu Tyr Ser Asp Pro Val Arg Phe Asn Pro Pro Gly Thr 
625                 630                 635                 640 


Ser Gly Phe Pro Ser Phe Asn Leu Ile Phe Val Gly Leu Ser Ala Asn 
                645                 650                 655     


Glu Asn Val Tyr Ile Asp Lys Ile Glu Cys Ile Pro Val Thr Lys Asp 
            660                 665                 670         


Asp Leu Asp Lys Glu Thr Leu Glu Lys Ala Glu Lys Ala Val Asn Ala 
        675                 680                 685             


Leu Phe Ile Asp Gly Thr Gln Asn Leu Lys Thr Glu Val Thr Asp Tyr 
    690                 695                 700                 


Cys Ile Asp Gln Val Ser Met Ile Ile Asp Cys Val Ser Glu Glu Leu 
705                 710                 715                 720 


Tyr Pro Asn Glu Lys Arg Asp Leu Leu Tyr Leu Val Lys His Ala Lys 
                725                 730                 735     


Arg Gln Ser Asn Thr Arg Asn Leu Ile Leu Asp Ser Asn Phe Thr Ser 
            740                 745                 750         


Ile Asn Ser Glu Asp Val Asn Gly Trp Tyr Gly Ser Pro Gly Leu Ile 
        755                 760                 765             


Val Glu Ser Gly Asp Val Val Phe Lys Glu Asn Tyr Val His Leu Arg 
    770                 775                 780                 


Gly Pro Asn Asp Glu Arg Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp 
785                 790                 795                 800 


Glu Ser Lys Leu Thr Glu Tyr Thr Arg Tyr Gln Leu Arg Gly Phe Ile 
                805                 810                 815     


Glu Gly Ser Arg Gly Leu Glu Val Tyr Val Ile Arg Tyr Asp Ala Lys 
            820                 825                 830         


His Glu Thr Leu Asn Val Leu Gly Asp Leu Ser Leu Asp Asn Leu Ser 
        835                 840                 845             


Tyr Asn Glu Cys Gly Gln Pro Asp Arg Cys Ser Gln Glu Pro Tyr Ile 
    850                 855                 860                 


Glu Gln Arg Leu Gln Gln Glu Glu Val Ala Asn Glu Arg Ala Cys His 
865                 870                 875                 880 


Phe Asp Ser Asn Asp Ser Leu Ser Ser Ser Asn Gly Tyr Pro Ser Asp 
                885                 890                 895     


Ser His His Leu Ser Leu His Val Asp Thr Gly Ser Ile Asp Phe Lys 
            900                 905                 910         


Glu Asn Leu Gly Ile Trp Ile Leu Phe Lys Leu Ser Thr Thr Asp Gly 
        915                 920                 925             


Tyr Ala Lys Ile Gly Asn Ile Glu Leu Val Glu Glu Gly Pro Leu Thr 
    930                 935                 940                 


Gly Ser Ala Leu Gly Ser Ile Lys Arg Met Glu Asn Lys Trp Lys Glu 
945                 950                 955                 960 


Lys Val Glu Ser Ile Arg Leu Gln Gly Lys Lys Ala Tyr Asp Thr Ala 
                965                 970                 975     


Lys Leu Tyr Ile Asp Asn Leu Phe Glu Gly Ser Gln Asn Thr Lys Leu 
            980                 985                 990         


Tyr Pro Phe Val Thr Phe Leu Thr  Leu Ser Asn Ala Arg  Gln Leu Ile 
        995                 1000                 1005             


Asn Lys  Ile Tyr Asn Lys Tyr  Ser Pro Trp Leu Ser  Leu Ile Pro 
    1010                 1015                 1020             


Gly Val  Asn Tyr Asp Leu Phe  Glu Glu Leu Ala Val  Arg Phe Gln 
    1025                 1030                 1035             


Asn Ala  Leu Gln Leu Tyr Asp  Thr Arg Asn Leu Ile  Gln Asn Gly 
    1040                 1045                 1050             


Arg Phe  Ile Asp Gly Leu Val  Ser Trp Met Thr Thr  Pro Gly Val 
    1055                 1060                 1065             


Gln Val  Arg Lys Asp Ser Ala  Ser Ser Ile Leu Glu  Leu Asn Ser 
    1070                 1075                 1080             


Trp Glu  Glu Gln Val Val Gln  Lys Val Pro Val Cys  Gln Gly Tyr 
    1085                 1090                 1095             


Gly Tyr  Val Leu Arg Val Thr  Ala Ser Lys Glu Asp  Leu Gly Glu 
    1100                 1105                 1110             


Gly Tyr  Ile Lys Val Ser Asp  Glu Met Gly Asn Ser  Asp Thr Ile 
    1115                 1120                 1125             


Ile Phe  Ser Ala Cys Asn Asn  Ser Asn Asn Asp Val  Ser Ile Asn 
    1130                 1135                 1140             


Asn Tyr  Val Thr Gln Glu Leu  Glu Phe Phe Pro Asp  Ser Asp Tyr 
    1145                 1150                 1155             


Val His  Leu Glu Ile Gly Glu  Thr Glu Gly Thr Phe  Gln Ile Val 
    1160                 1165                 1170             


Ser Val  Glu Leu Ile Leu Met  Glu Asp 
    1175                 1180         


<210>  4
<211>  1091
<212>  PRT
<213>  Bacillus thuringiensis

<400>  4

Met Tyr Gln Lys Leu Phe Asn Tyr Leu Trp Pro Tyr Glu Asp Thr Ser 
1               5                   10                  15      


Glu Trp Asp Lys Met Met Ala Ala Val Glu Ala Leu Ile Asn Gln Lys 
            20                  25                  30          


Ile Asn Glu Thr Val Lys Ser Leu Ala Leu Ala Asp Leu Asp Gly Leu 
        35                  40                  45              


Gly Arg Asn Leu Lys Ser Tyr Gly Asn Ala Leu Lys Asn Trp Asn Glu 
    50                  55                  60                  


Asn Lys Asn Asp Ala Asp Ser Thr Ala Leu Val Leu Asp Arg Phe Arg 
65                  70                  75                  80  


Thr Val Asn Glu Leu Phe Val Asn Asp Met Ala Ser Phe Ala Pro Lys 
                85                  90                  95      


Gly Tyr Glu Val Leu Leu Leu Asp Val Tyr Ala Lys Ala Ala Asn Leu 
            100                 105                 110         


His Leu Leu Phe Leu Arg Asp Ala Glu Leu Tyr Gly Ala Asp Trp Gly 
        115                 120                 125             


Met Pro Glu Asp Glu Ile Asn Leu Phe Tyr Gln Glu Gln Glu Asp Tyr 
    130                 135                 140                 


Arg Lys Glu Tyr Ser Asp His Cys Ile Ser Trp Tyr Gln Lys Gly Leu 
145                 150                 155                 160 


Asn Gln Phe Asn Lys Ser Ser Ala Leu Asp Trp Ile Lys Tyr Asn Arg 
                165                 170                 175     


Tyr Arg Thr Gln Met Thr Ile Asn Val Leu Asp Phe Val Ala Leu Tyr 
            180                 185                 190         


Pro Asn Tyr Asp Val Arg Lys Tyr Pro Met Ser Thr His Thr Glu Leu 
        195                 200                 205             


Thr Arg Thr Val Tyr Ser Asp Pro Ile Gly Phe Asp Glu Arg Thr Gly 
    210                 215                 220                 


Thr Gly Thr Ser Gly Val Arg Ala Trp Tyr Glu Ala Gly Arg Ser Phe 
225                 230                 235                 240 


Ala Glu Ile Glu Asn Asn Ala Ile Pro Ala Pro Asp Ile Val Lys Phe 
                245                 250                 255     


Ile Asn Lys Leu Thr Val Tyr Ser Lys Arg Ile Asn Ala Ser Pro Phe 
            260                 265                 270         


Met Ala Thr Arg Trp Ala Gly His Ser Ile Thr Gln Asp Thr Thr Phe 
        275                 280                 285             


Thr Gly Ser Ala Gln Glu Ile Lys Tyr Gly Asp Val Ser Gly Val Pro 
    290                 295                 300                 


Thr Thr Phe Leu Phe Lys Asn Thr Asp Ile Tyr Arg Thr Ile Ser Thr 
305                 310                 315                 320 


Val Gly Thr Tyr Tyr Tyr Thr Asn Gly Pro Tyr Lys Leu Pro Leu Ser 
                325                 330                 335     


Lys Val His Phe Tyr Gly Ile Asn Thr Ser Asn Arg Lys Glu Thr Phe 
            340                 345                 350         


Asn Tyr Asp Gln Asp Ile Asn Phe Lys Phe Gln His Gln Lys Asp Ser 
        355                 360                 365             


Ser Asn Glu Ile Ala Val Val Leu Pro Gly Pro Thr Asp Tyr Gly Asp 
    370                 375                 380                 


Tyr Asn Lys Tyr Ser His Arg Leu Ser Tyr Ile Ser Asp Ala Pro Ile 
385                 390                 395                 400 


Lys Gln Phe Thr Gly Leu Ser Ser Asn Glu Gly Phe Val Pro Val Phe 
                405                 410                 415     


Gly Trp Met His Ser Ser Thr Thr Arg Lys Asn Phe Leu Ser Ala Asn 
            420                 425                 430         


Gln Ile Thr Gln Ile Pro Ala Val Lys Ser His Glu Tyr Asn Ser Ser 
        435                 440                 445             


Met Ala Ile Val Ser Ser Asn Gly Tyr Cys Gly Gly Tyr Ile Met Lys 
    450                 455                 460                 


Val Ser Lys Val Phe Pro Phe Asn Glu Val Thr Ala Gly Asn Tyr Val 
465                 470                 475                 480 


Val Asp Cys Glu Asp Tyr Ser Gln Gln Phe Arg Phe Arg Val Arg Tyr 
                485                 490                 495     


Ala Ser Thr Val Ser Cys Pro Leu Arg Phe Ala Thr Phe Ser Ile Ser 
            500                 505                 510         


Gly Pro Thr Val Asn Leu Glu Lys Thr Leu Gln Lys Gly Asp Glu Ile 
        515                 520                 525             


Lys Tyr Ser Ser Phe Lys Tyr Ser Glu Tyr Ser Asp Pro Val Arg Phe 
    530                 535                 540                 


Asn Pro Pro Gly Thr Ser Gly Phe Pro Ser Phe Asn Leu Ile Phe Val 
545                 550                 555                 560 


Gly Leu Ser Ala Asn Glu Asn Val Tyr Ile Asp Lys Ile Glu Cys Ile 
                565                 570                 575     


Pro Val Thr Lys Asp Asp Leu Asp Lys Glu Thr Leu Glu Lys Ala Glu 
            580                 585                 590         


Lys Ala Val Asn Ala Leu Phe Ile Asp Gly Thr Gln Asn Leu Lys Thr 
        595                 600                 605             


Glu Val Thr Asp Tyr Cys Ile Asp Gln Val Ser Met Ile Ile Asp Cys 
    610                 615                 620                 


Val Ser Glu Glu Leu Tyr Pro Asn Glu Lys Arg Asp Leu Leu Tyr Leu 
625                 630                 635                 640 


Val Lys His Ala Lys Arg Gln Ser Asn Thr Arg Asn Leu Ile Leu Asp 
                645                 650                 655     


Ser Asn Phe Thr Ser Ile Asn Ser Glu Asp Val Asn Gly Trp Tyr Gly 
            660                 665                 670         


Ser Pro Gly Leu Ile Val Glu Ser Gly Asp Val Val Phe Lys Glu Asn 
        675                 680                 685             


Tyr Val His Leu Arg Gly Pro Asn Asp Glu Arg Tyr Pro Thr Tyr Leu 
    690                 695                 700                 


Tyr Gln Lys Ile Asp Glu Ser Lys Leu Thr Glu Tyr Thr Arg Tyr Gln 
705                 710                 715                 720 


Leu Arg Gly Phe Ile Glu Gly Ser Arg Gly Leu Glu Val Tyr Val Ile 
                725                 730                 735     


Arg Tyr Asp Ala Lys His Glu Thr Leu Asn Val Leu Gly Asp Leu Ser 
            740                 745                 750         


Leu Asp Asn Leu Ser Tyr Asn Glu Cys Gly Gln Pro Asp Arg Cys Ser 
        755                 760                 765             


Gln Glu Pro Tyr Ile Glu Gln Arg Leu Gln Gln Glu Glu Val Ala Asn 
    770                 775                 780                 


Glu Arg Ala Cys His Phe Asp Ser Asn Asp Ser Leu Ser Ser Ser Asn 
785                 790                 795                 800 


Gly Tyr Pro Ser Asp Ser His His Leu Ser Leu His Val Asp Thr Gly 
                805                 810                 815     


Ser Ile Asp Phe Lys Glu Asn Leu Gly Ile Trp Ile Leu Phe Lys Leu 
            820                 825                 830         


Ser Thr Thr Asp Gly Tyr Ala Lys Ile Gly Asn Ile Glu Leu Val Glu 
        835                 840                 845             


Glu Gly Pro Leu Thr Gly Ser Ala Leu Gly Ser Ile Lys Arg Met Glu 
    850                 855                 860                 


Asn Lys Trp Lys Glu Lys Val Glu Ser Ile Arg Leu Gln Gly Lys Lys 
865                 870                 875                 880 


Ala Tyr Asp Thr Ala Lys Leu Tyr Ile Asp Asn Leu Phe Glu Gly Ser 
                885                 890                 895     


Gln Asn Thr Lys Leu Tyr Pro Phe Val Thr Phe Leu Thr Leu Ser Asn 
            900                 905                 910         


Ala Arg Gln Leu Ile Asn Lys Ile Tyr Asn Lys Tyr Ser Pro Trp Leu 
        915                 920                 925             


Ser Leu Ile Pro Gly Val Asn Tyr Asp Leu Phe Glu Glu Leu Ala Val 
    930                 935                 940                 


Arg Phe Gln Asn Ala Leu Gln Leu Tyr Asp Thr Arg Asn Leu Ile Gln 
945                 950                 955                 960 


Asn Gly Arg Phe Ile Asp Gly Leu Val Ser Trp Met Thr Thr Pro Gly 
                965                 970                 975     


Val Gln Val Arg Lys Asp Ser Ala Ser Ser Ile Leu Glu Leu Asn Ser 
            980                 985                 990         


Trp Glu Glu Gln Val Val Gln Lys  Val Pro Val Cys Gln  Gly Tyr Gly 
        995                 1000                 1005             


Tyr Val  Leu Arg Val Thr Ala  Ser Lys Glu Asp Leu  Gly Glu Gly 
    1010                 1015                 1020             


Tyr Ile  Lys Val Ser Asp Glu  Met Gly Asn Ser Asp  Thr Ile Ile 
    1025                 1030                 1035             


Phe Ser  Ala Cys Asn Asn Ser  Asn Asn Asp Val Ser  Ile Asn Asn 
    1040                 1045                 1050             


Tyr Val  Thr Gln Glu Leu Glu  Phe Phe Pro Asp Ser  Asp Tyr Val 
    1055                 1060                 1065             


His Leu  Glu Ile Gly Glu Thr  Glu Gly Thr Phe Gln  Ile Val Ser 
    1070                 1075                 1080             


Val Glu  Leu Ile Leu Met Glu  Asp 
    1085                 1090     


<210>  5
<211>  669
<212>  PRT
<213>  Bacillus thuringiensis

<400>  5

Met Lys Ile Asn Asp Val Asn Glu Trp Asp Asn Val Ala Glu Val Thr 
1               5                   10                  15      


Glu Asn Pro Leu Ala Pro Ser Ile Pro Tyr Asn Val Leu Gln Arg Lys 
            20                  25                  30          


Glu Asn Thr Ala Asn Glu Leu Thr Tyr Asp Asn Tyr Asn Phe Gln Asp 
        35                  40                  45              


Phe Leu Thr Leu Gly Tyr Glu Asp Ile Thr Gln Ala Ala Asn Ala Gln 
    50                  55                  60                  


Asp Val Ile Asn Thr Thr Leu Asn Val Thr Ala Thr Ile Leu Asn Phe 
65                  70                  75                  80  


Leu Gly Val Pro Tyr Ala Gly Thr Val Ile Ser Met Tyr Gln Lys Leu 
                85                  90                  95      


Phe Asn Tyr Leu Trp Pro Tyr Glu Asp Thr Ser Glu Trp Asp Lys Met 
            100                 105                 110         


Met Ala Ala Val Glu Ala Leu Ile Asn Gln Lys Ile Asn Glu Thr Val 
        115                 120                 125             


Lys Ser Leu Ala Leu Ala Asp Leu Asp Gly Leu Gly Arg Asn Leu Lys 
    130                 135                 140                 


Ser Tyr Gly Asn Ala Leu Lys Asn Trp Asn Glu Asn Lys Asn Asp Ala 
145                 150                 155                 160 


Asp Ser Thr Ala Leu Val Leu Asp Arg Phe Arg Thr Val Asn Glu Leu 
                165                 170                 175     


Phe Val Asn Asp Met Ala Ser Phe Ala Pro Lys Gly Tyr Glu Val Leu 
            180                 185                 190         


Leu Leu Asp Val Tyr Ala Lys Ala Ala Asn Leu His Leu Leu Phe Leu 
        195                 200                 205             


Arg Asp Ala Glu Leu Tyr Gly Ala Asp Trp Gly Met Pro Glu Asp Glu 
    210                 215                 220                 


Ile Asn Leu Phe Tyr Gln Glu Gln Glu Asp Tyr Arg Lys Glu Tyr Ser 
225                 230                 235                 240 


Asp His Cys Ile Ser Trp Tyr Gln Lys Gly Leu Asn Gln Phe Asn Lys 
                245                 250                 255     


Ser Ser Ala Leu Asp Trp Ile Lys Tyr Asn Arg Tyr Arg Thr Gln Met 
            260                 265                 270         


Thr Ile Asn Val Leu Asp Phe Val Ala Leu Tyr Pro Asn Tyr Asp Val 
        275                 280                 285             


Arg Lys Tyr Pro Met Ser Thr His Thr Glu Leu Thr Arg Thr Val Tyr 
    290                 295                 300                 


Ser Asp Pro Ile Gly Phe Asp Glu Arg Thr Gly Thr Gly Thr Ser Gly 
305                 310                 315                 320 


Val Arg Ala Trp Tyr Glu Ala Gly Arg Ser Phe Ala Glu Ile Glu Asn 
                325                 330                 335     


Asn Ala Ile Pro Ala Pro Asp Ile Val Lys Phe Ile Asn Lys Leu Thr 
            340                 345                 350         


Val Tyr Ser Lys Arg Ile Asn Ala Ser Pro Phe Met Ala Thr Arg Trp 
        355                 360                 365             


Ala Gly His Ser Ile Thr Gln Asp Thr Thr Phe Thr Gly Ser Ala Gln 
    370                 375                 380                 


Glu Ile Lys Tyr Gly Asp Val Ser Gly Val Pro Thr Thr Phe Leu Phe 
385                 390                 395                 400 


Lys Asn Thr Asp Ile Tyr Arg Thr Ile Ser Thr Val Gly Thr Tyr Tyr 
                405                 410                 415     


Tyr Thr Asn Gly Pro Tyr Lys Leu Pro Leu Ser Lys Val His Phe Tyr 
            420                 425                 430         


Gly Ile Asn Thr Ser Asn Arg Lys Glu Thr Phe Asn Tyr Asp Gln Asp 
        435                 440                 445             


Ile Asn Phe Lys Phe Gln His Gln Lys Asp Ser Ser Asn Glu Ile Ala 
    450                 455                 460                 


Val Val Leu Pro Gly Pro Thr Asp Tyr Gly Asp Tyr Asn Lys Tyr Ser 
465                 470                 475                 480 


His Arg Leu Ser Tyr Ile Ser Asp Ala Pro Ile Lys Gln Phe Thr Gly 
                485                 490                 495     


Leu Ser Ser Asn Glu Gly Phe Val Pro Val Phe Gly Trp Met His Ser 
            500                 505                 510         


Ser Thr Thr Arg Lys Asn Phe Leu Ser Ala Asn Gln Ile Thr Gln Ile 
        515                 520                 525             


Pro Ala Val Lys Ser His Glu Tyr Asn Ser Ser Met Ala Ile Val Ser 
    530                 535                 540                 


Ser Asn Gly Tyr Cys Gly Gly Tyr Ile Met Lys Val Ser Lys Val Phe 
545                 550                 555                 560 


Pro Phe Asn Glu Val Thr Ala Gly Asn Tyr Val Val Asp Cys Glu Asp 
                565                 570                 575     


Tyr Ser Gln Gln Phe Arg Phe Arg Val Arg Tyr Ala Ser Thr Val Ser 
            580                 585                 590         


Cys Pro Leu Arg Phe Ala Thr Phe Ser Ile Ser Gly Pro Thr Val Asn 
        595                 600                 605             


Leu Glu Lys Thr Leu Gln Lys Gly Asp Glu Ile Lys Tyr Ser Ser Phe 
    610                 615                 620                 


Lys Tyr Ser Glu Tyr Ser Asp Pro Val Arg Phe Asn Pro Pro Gly Thr 
625                 630                 635                 640 


Ser Gly Phe Pro Ser Phe Asn Leu Ile Phe Val Gly Leu Ser Ala Asn 
                645                 650                 655     


Glu Asn Val Tyr Ile Asp Lys Ile Glu Cys Ile Pro Val 
            660                 665                 


<210>  6
<211>  578
<212>  PRT
<213>  Bacillus thuringiensis

<400>  6

Met Tyr Gln Lys Leu Phe Asn Tyr Leu Trp Pro Tyr Glu Asp Thr Ser 
1               5                   10                  15      


Glu Trp Asp Lys Met Met Ala Ala Val Glu Ala Leu Ile Asn Gln Lys 
            20                  25                  30          


Ile Asn Glu Thr Val Lys Ser Leu Ala Leu Ala Asp Leu Asp Gly Leu 
        35                  40                  45              


Gly Arg Asn Leu Lys Ser Tyr Gly Asn Ala Leu Lys Asn Trp Asn Glu 
    50                  55                  60                  


Asn Lys Asn Asp Ala Asp Ser Thr Ala Leu Val Leu Asp Arg Phe Arg 
65                  70                  75                  80  


Thr Val Asn Glu Leu Phe Val Asn Asp Met Ala Ser Phe Ala Pro Lys 
                85                  90                  95      


Gly Tyr Glu Val Leu Leu Leu Asp Val Tyr Ala Lys Ala Ala Asn Leu 
            100                 105                 110         


His Leu Leu Phe Leu Arg Asp Ala Glu Leu Tyr Gly Ala Asp Trp Gly 
        115                 120                 125             


Met Pro Glu Asp Glu Ile Asn Leu Phe Tyr Gln Glu Gln Glu Asp Tyr 
    130                 135                 140                 


Arg Lys Glu Tyr Ser Asp His Cys Ile Ser Trp Tyr Gln Lys Gly Leu 
145                 150                 155                 160 


Asn Gln Phe Asn Lys Ser Ser Ala Leu Asp Trp Ile Lys Tyr Asn Arg 
                165                 170                 175     


Tyr Arg Thr Gln Met Thr Ile Asn Val Leu Asp Phe Val Ala Leu Tyr 
            180                 185                 190         


Pro Asn Tyr Asp Val Arg Lys Tyr Pro Met Ser Thr His Thr Glu Leu 
        195                 200                 205             


Thr Arg Thr Val Tyr Ser Asp Pro Ile Gly Phe Asp Glu Arg Thr Gly 
    210                 215                 220                 


Thr Gly Thr Ser Gly Val Arg Ala Trp Tyr Glu Ala Gly Arg Ser Phe 
225                 230                 235                 240 


Ala Glu Ile Glu Asn Asn Ala Ile Pro Ala Pro Asp Ile Val Lys Phe 
                245                 250                 255     


Ile Asn Lys Leu Thr Val Tyr Ser Lys Arg Ile Asn Ala Ser Pro Phe 
            260                 265                 270         


Met Ala Thr Arg Trp Ala Gly His Ser Ile Thr Gln Asp Thr Thr Phe 
        275                 280                 285             


Thr Gly Ser Ala Gln Glu Ile Lys Tyr Gly Asp Val Ser Gly Val Pro 
    290                 295                 300                 


Thr Thr Phe Leu Phe Lys Asn Thr Asp Ile Tyr Arg Thr Ile Ser Thr 
305                 310                 315                 320 


Val Gly Thr Tyr Tyr Tyr Thr Asn Gly Pro Tyr Lys Leu Pro Leu Ser 
                325                 330                 335     


Lys Val His Phe Tyr Gly Ile Asn Thr Ser Asn Arg Lys Glu Thr Phe 
            340                 345                 350         


Asn Tyr Asp Gln Asp Ile Asn Phe Lys Phe Gln His Gln Lys Asp Ser 
        355                 360                 365             


Ser Asn Glu Ile Ala Val Val Leu Pro Gly Pro Thr Asp Tyr Gly Asp 
    370                 375                 380                 


Tyr Asn Lys Tyr Ser His Arg Leu Ser Tyr Ile Ser Asp Ala Pro Ile 
385                 390                 395                 400 


Lys Gln Phe Thr Gly Leu Ser Ser Asn Glu Gly Phe Val Pro Val Phe 
                405                 410                 415     


Gly Trp Met His Ser Ser Thr Thr Arg Lys Asn Phe Leu Ser Ala Asn 
            420                 425                 430         


Gln Ile Thr Gln Ile Pro Ala Val Lys Ser His Glu Tyr Asn Ser Ser 
        435                 440                 445             


Met Ala Ile Val Ser Ser Asn Gly Tyr Cys Gly Gly Tyr Ile Met Lys 
    450                 455                 460                 


Val Ser Lys Val Phe Pro Phe Asn Glu Val Thr Ala Gly Asn Tyr Val 
465                 470                 475                 480 


Val Asp Cys Glu Asp Tyr Ser Gln Gln Phe Arg Phe Arg Val Arg Tyr 
                485                 490                 495     


Ala Ser Thr Val Ser Cys Pro Leu Arg Phe Ala Thr Phe Ser Ile Ser 
            500                 505                 510         


Gly Pro Thr Val Asn Leu Glu Lys Thr Leu Gln Lys Gly Asp Glu Ile 
        515                 520                 525             


Lys Tyr Ser Ser Phe Lys Tyr Ser Glu Tyr Ser Asp Pro Val Arg Phe 
    530                 535                 540                 


Asn Pro Pro Gly Thr Ser Gly Phe Pro Ser Phe Asn Leu Ile Phe Val 
545                 550                 555                 560 


Gly Leu Ser Ala Asn Glu Asn Val Tyr Ile Asp Lys Ile Glu Cys Ile 
                565                 570                 575     


Pro Val 
        


<210>  7
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  endoplasmic reticulum targeting peptide

<400>  7

Lys Asp Glu Leu 
1               


