                               SEQUENCE LISTING

<110> TO BE DETERMINED
 
<120> RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS (RSV) AND VACCINES

<130> DM22-100P1

<140>
<141>

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 1725
<212> DNA
<213> Respiratory syncytial virus

<220>
<223> nucleotide sequence of F0 from RSV strain A2

<400> 1
atggagttgc taatcctcaa agcaaatgca attaccacaa tcctcactgc agtcacattt       60

tgttttgctt ctggtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt      120

agcaaaggct atcttagtgc tctgagaact ggttggtata ccagtgttat aactatagaa      180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgataaaa      240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca      300

caagcaacaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac      360

aatgccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt      420

ttgttaggtg ttggatctgc aatcgccagt ggcgttgctg tatctaaggt cctgcaccta      480

gaaggggaag tgaacaagat caaaagtgct ctactatcca caaacaaggc tgtagtcagc      540

ttatcaaatg gagttagtgt cttaaccagc aaagtgttag acctcaaaaa ctatatagat      600

aaacaattgt tacctattgt gaacaagcaa agctgcagca tatcaaatat agaaactgtg      660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat      720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta      780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata      840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta      900

gtacaattac cactatatgg tgttatagat acaccctgtt ggaaactaca cacatcccct      960

ctatgtacaa ccaacacaaa agaagggtcc aacatctgtt taacaagaac tgacagagga     1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaac atgtaaagtt     1080

caatcaaatc gagtattttg tgacacaatg aacagtttaa cattaccaag tgaagtaaat     1140

ctctgcaatg ttgacatatt caaccccaaa tatgattgta aaattatgac ttcaaaaaca     1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact     1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgcgat     1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat     1380

aagcaagaag gtaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca     1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaacga gaagattaac     1500

cagagcctag catttattcg taaatccgat gaattattac ataatgtaaa tgccggtaaa     1560

tccaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca     1620

ttaattgctg ttggactgct cttatactgt aaggccagaa gcacaccagt cacactaagc     1680

aaagatcaac tgagtggtat aaataatatt gcatttagta actaa                     1725


<210> 2
<211> 574
<212> PRT
<213> Respiratory syncytial virus

<220>
<223> amino acid sequence of F0 from RSV strain A2

<400> 2
Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Lys Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Gln Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210> 3
<211> 273
<212> DNA
<213> Respiratory syncytial virus

<220>
<223> nucleotide sequence of M2-2 from RSV strain A2

<400> 3
atgaccatgc caaaaataat gatactacct gacaaatatc cttgtagtat aacttccata       60

ctaataacaa gtagatgtag agttactatg tataatcaaa agaacacact atatttcaac      120

caaaacaacc caaataacca tatgtactca ccgaatcaaa cattcaatga aatccattgg      180

acctctcaag aattgattga cacaattcaa aattttctac aacatctagg tattattgag      240

gatatatata caatatatat attagtgtca taa                                   273


<210> 4
<211> 90
<212> PRT
<213> Respiratory syncytial virus

<220>
<223> amino acid sequence of M2-2 from RSV strain A2

<400> 4
Met Thr Met Pro Lys Ile Met Ile Leu Pro Asp Lys Tyr Pro Cys Ser 
1               5                   10                  15      


Ile Thr Ser Ile Leu Ile Thr Ser Arg Cys Arg Val Thr Met Tyr Asn 
            20                  25                  30          


Gln Lys Asn Thr Leu Tyr Phe Asn Gln Asn Asn Pro Asn Asn His Met 
        35                  40                  45              


Tyr Ser Pro Asn Gln Thr Phe Asn Glu Ile His Trp Thr Ser Gln Glu 
    50                  55                  60                  


Leu Ile Asp Thr Ile Gln Asn Phe Leu Gln His Leu Gly Ile Ile Glu 
65                  70                  75                  80  


Asp Ile Tyr Thr Ile Tyr Ile Leu Val Ser 
                85                  90  


<210> 5
<211> 15328
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      nucleotide sequence of rA2deltaM2-2 cDNA 

<400> 5
acgggaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt       60

tgataagtac cacttaaatt taactccctt ggttagagat gggcagcaat tcattgagta      120

tgataaaagt tagattacaa aatttgtttg acaatgatga agtagcattg ttaaaaataa      180

catgctatac tgataaatta atacatttaa ctaatgcttt ggctaaggca gtgatacata      240

caatcaaatt gaatggcatt gtgtttgtgc atgttattac aagtagtgat atttgcccta      300

ataataatat tgtagtaaaa tccaatttca caacaatgcc agtactacaa aatggaggtt      360

atatatggga aatgatggaa ttaacacatt gctctcaacc taacggtcta ctagatgaca      420

attgtgaaat taaattctcc aaaaaactaa gtgattcaac aatgaccaat tatatgaatc      480

aattatctga attacttgga tttgatctta atccataaat tataattaat atcaactagc      540

aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc      600

aaataaatca attcagccaa cccaaccatg gacacaaccc acaatgataa tacaccacaa      660

agactgatga tcacagacat gagaccgttg tcacttgaga ccataataac atcactaacc      720

agagacatca taacacacaa atttatatac ttgataaatc atgaatgcat agtgagaaga      780

cttgatgaaa gacaggccac atttacattc ctggtcaact atgaaatgaa actattacac      840

aaagtaggaa gcactaaata taaaaaatat actgaataca acacaaaata tggcactttc      900

cctatgccaa tattcatcaa tcatgatggg ttcttagaat gcattggcat taagcctaca      960

aagcatactc ccataatata caagtatgat ctcaatccat aaatttcaac acaatattca     1020

cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa     1080

aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga     1140

tggctcttag caaagtcaag ttgaatgata cactcaacaa ggatcaactt ctgtcatcca     1200

gcaaatacgc catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc     1260

agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat     1320

tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa     1380

aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc     1440

gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa     1500

ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag     1560

aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat     1620

tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag     1680

ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac     1740

tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag     1800

atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag     1860

ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg     1920

gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa     1980

tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct     2040

accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct     2100

ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac     2160

cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg     2220

gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc     2280

agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa     2340

tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta     2400

aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata     2460

gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa     2520

attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt     2580

atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt     2640

ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt     2700

catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg     2760

atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac     2820

ctacatctgc tcgggatggt ataagagatg ccatggttgg tttaagagaa gaaatgatag     2880

aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca     2940

ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa     3000

catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg     3060

aagatttctg attagttacc aatcttcaca tcaacacaca ataccaacag aagaccaaca     3120

aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca     3180

aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa     3240

aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat     3300

acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa     3360

tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta     3420

atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga     3480

taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg     3540

tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg     3600

catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta     3660

tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa     3720

catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc     3780

tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa     3840

tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca     3900

aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa     3960

gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca     4020

tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac     4080

attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact     4140

tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt     4200

aataaaaaat atacacatgg ggcaaataat cattggagga aatccaacta atcacaatat     4260

ctgttaacat agacaagtcc acacaccata cagaatcaac caatggaaaa tacatccata     4320

acaatagaat tctcaagcaa attctggcct tactttacac taatacacat gatcacaaca     4380

ataatctctt tgctaatcat aatctccatc atgattgcaa tactaaacaa actttgtgaa     4440

tataacgtat tccataacaa aacctttgag ttaccaagag ctcgagtcaa cacatagcat     4500

tcatcaatcc aacagcccaa aacagtaacc ttgcatttaa aaatgaacaa cccctacctc     4560

tttacaacac ctcattaaca tcccaccatg caaaccacta tccatactat aaagtagtta     4620

attaaaaata gtcataacaa tgaactagga tatcaagact aacaataaca ttggggcaaa     4680

tgcaaacatg tccaaaaaca aggaccaacg caccgctaag acattagaaa ggacctggga     4740

cactctcaat catttattat tcatatcatc gtgcttatat aagttaaatc ttaaatctgt     4800

agcacaaatc acattatcca ttctggcaat gataatctca acttcactta taattgcagc     4860

catcatattc atagcctcgg caaaccacaa agtcacacca acaactgcaa tcatacaaga     4920

tgcaacaagc cagatcaaga acacaacccc aacatacctc acccagaatc ctcagcttgg     4980

aatcagtccc tctaatccgt ctgaaattac atcacaaatc accaccatac tagcttcaac     5040

aacaccagga gtcaagtcaa ccctgcaatc cacaacagtc aagaccaaaa acacaacaac     5100

aactcaaaca caacccagca agcccaccac aaaacaacgc caaaacaaac caccaagcaa     5160

acccaataat gattttcact ttgaagtgtt caactttgta ccctgcagca tatgcagcaa     5220

caatccaacc tgctgggcta tctgcaaaag aataccaaac aaaaaaccag gaaagaaaac     5280

cactaccaag cccacaaaaa aaccaaccct caagacaacc aaaaaagatc ccaaacctca     5340

aaccactaaa tcaaaggaag tacccaccac caagcccaca gaagagccaa ccatcaacac     5400

caccaaaaca aacatcataa ctacactact cacctccaac accacaggaa atccagaact     5460

cacaagtcaa atggaaacct tccactcaac ttcctccgaa ggcaatccaa gcccttctca     5520

agtctctaca acatccgagt acccatcaca accttcatct ccacccaaca caccacgcca     5580

gtagttactt aaaaacatat tatcacaaaa agccatgacc aacttaaaca gaatcaaagt     5640

aaactctggg gcaaataaca atggagttgc taatcctcaa agcaaatgca attaccacaa     5700

tcctcactgc agtcacattt tgttttgctt ctggtcaaaa catcactgaa gaattttatc     5760

aatcaacatg cagtgcagtt agcaaaggct atcttagtgc tctgagaact ggttggtata     5820

ccagtgttat aactatagaa ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg     5880

ctaaggtaaa attgataaaa caagaattag ataaatataa aaatgctgta acagaattgc     5940

agttgctcat gcaaagcaca caagcaacaa acaatcgagc cagaagagaa ctaccaaggt     6000

ttatgaatta tacactcaac aatgccaaaa aaaccaatgt aacattaagc aagaaaagga     6060

aaagaagatt tcttggtttt ttgttaggtg ttggatctgc aatcgccagt ggcgttgctg     6120

tatctaaggt cctgcaccta gaaggggaag tgaacaagat caaaagtgct ctactatcca     6180

caaacaaggc tgtagtcagc ttatcaaatg gagtcagtgt cttaaccagc aaagtgttag     6240

acctcaaaaa ctatatagat aaacaattgt tacctattgt gaacaagcaa agctgcagca     6300

tatcaaatat agaaactgtg atagagttcc aacaaaagaa caacagacta ctagagatta     6360

ccagggaatt tagtgttaat gcaggtgtaa ctacacctgt aagcacttac atgttaacta     6420

atagtgaatt attgtcatta atcaatgata tgcctataac aaatgatcag aaaaagttaa     6480

tgtccaacaa tgttcaaata gttagacagc aaagttactc tatcatgtcc ataataaaag     6540

aggaagtctt agcatatgta gtacaattac cactatatgg tgttatagat acaccctgtt     6600

ggaaactaca cacatcccct ctatgtacaa ccaacacaaa agaagggtcc aacatctgtt     6660

taacaagaac tgacagagga tggtactgtg acaatgcagg atcagtatct ttcttcccac     6720

aagctgaaac atgtaaagtt caatcaaatc gagtattttg tgacacaatg aacagtttaa     6780

cattaccaag tgaagtaaat ctctgcaatg ttgacatatt caaccccaaa tatgattgta     6840

aaattatgac ttcaaaaaca gatgtaagca gctccgttat cacatctcta ggagccattg     6900

tgtcatgcta tggcaaaact aaatgtacag catccaataa aaatcgtgga atcataaaga     6960

cattttctaa cgggtgcgat tatgtatcaa ataaaggggt ggacactgtg tctgtaggta     7020

acacattata ttatgtaaat aagcaagaag gtaaaagtct ctatgtaaaa ggtgaaccaa     7080

taataaattt ctatgaccca ttagtattcc cctctgatga atttgatgca tcaatatctc     7140

aagtcaacga gaagattaac cagagcctag catttattcg taaatccgat gaattattac     7200

ataatgtaaa tgccggtaaa tccaccacaa atatcatgat aactactata attatagtga     7260

ttatagtaat attgttatca ttaattgctg ttggactgct cttatactgt aaggccagaa     7320

gcacaccagt cacactaagc aaagatcaac tgagtggtat aaataatatt gcatttagta     7380

actaaataaa aatagcacct aatcatgttc ttacaatggt ttactatctg ctcatagaca     7440

acccatctgt cattggattt tcttaaaatc tgaacttcat tgaaactctc atctataaac     7500

catctcactt acactattta agtagattcc tagtttatag ttatataaaa cacaattgaa     7560

tgccagatta acttaccatc tgtaaaaatg aaaactgggg caaatatgtc acgaaggaat     7620

ccttgcaaat ttgaaattcg aggtcattgc ttaaatggta agaggtgtca ttttagtcat     7680

aattattttg aatggccacc gcatgcactg cttgtaagac aaaactttat gttaaacaga     7740

atacttaagt ctatggataa aagtatagat accttatcag aaataagtgg agctgcagag     7800

ttggacagaa cagaagagta tgctcttggt gtagttggag tgctagagag ttatatagga     7860

tcaataaaca atataactaa acaatcagca tgtgttgcca tgagcaaact cctcactgaa     7920

ctcaatagtg atgatatcaa aaagctgagg gacaatgaag agctaaattc acccaagata     7980

agagtgtaca atactgtcat atcatatatt gaaagcaaca ggaaaaacaa taaacaaact     8040

atccatctgt taaaaagatt gccagcagac gtattgaaga aaaccatcaa aaacacattg     8100

gatatccata agagcataac catcaacaac ccaaaagaat caactgttag tgatacaaat     8160

gaccatgcca aaaataatga tactacctga caaataagct tcaattctaa cactcaccac     8220

atcgttacat tattaattca aacaattcaa gttgtgggac aaaatggatc ccattattaa     8280

tggaaattct gctaatgttt atctaaccga tagttattta aaaggtgtta tctctttctc     8340

agagtgtaat gctttaggaa gttacatatt caatggtcct tatctcaaaa atgattatac     8400

caacttaatt agtagacaaa atccattaat agaacacatg aatctaaaga aactaaatat     8460

aacacagtcc ttaatatcta agtatcataa aggtgaaata aaattagaag aacctactta     8520

ttttcagtca ttacttatga catacaagag tatgacctcg tcagaacaga ttgctaccac     8580

taatttactt aaaaagataa taagaagagc tatagaaata agtgatgtca aagtctatgc     8640

tatattgaat aaactagggc ttaaagaaaa ggacaagatt aaatccaaca atggacaaga     8700

tgaagacaac tcagttatta cgaccataat caaagatgat atactttcag ctgttaaaga     8760

taatcaatct catcttaaag cagacaaaaa tcactctaca aaacaaaaag acacaatcaa     8820

aacaacactc ttgaagaaat tgatgtgttc aatgcaacat cctccatcat ggttaataca     8880

ttggtttaac ttatacacaa aattaaacaa catattaaca cagtatcgat caaatgaggt     8940

aaaaaaccat gggtttacat tgatagataa tcaaactctt agtggatttc aatttatttt     9000

gaaccaatat ggttgtatag tttatcataa ggaactcaaa agaattactg tgacaaccta     9060

taatcaattc ttgacatgga aagatattag ccttagtaga ttaaatgttt gtttaattac     9120

atggattagt aactgcttga acacattaaa taaaagctta ggcttaagat gcggattcaa     9180

taatgttatc ttgacacaac tattccttta tggagattgt atactaaagc tatttcacaa     9240

tgaggggttc tacataataa aagaggtaga gggatttatt atgtctctaa ttttaaatat     9300

aacagaagaa gatcaattca gaaaacgatt ttataatagt atgctcaaca acatcacaga     9360

tgctgctaat aaagctcaga aaaatctgct atcaagagta tgtcatacat tattagataa     9420

gacagtgtcc gataatataa taaatggcag atggataatt ctattaagta agttccttaa     9480

attaattaag cttgcaggtg acaataacct taacaatctg agtgaactat attttttgtt     9540

cagaatattt ggacacccaa tggtagatga aagacaagcc atggatgctg ttaaaattaa     9600

ttgcaatgag accaaatttt acttgttaag cagtctgagt atgttaagag gtgcctttat     9660

atatagaatt ataaaagggt ttgtaaataa ttacaacaga tggcctactt taagaaatgc     9720

tattgtttta cccttaagat ggttaactta ctataaacta aacacttatc cttctttgtt     9780

ggaacttaca gaaagagatt tgattgtgtt atcaggacta cgtttctatc gtgagtttcg     9840

gttgcctaaa aaagtggatc ttgaaatgat tataaatgat aaagctatat cacctcctaa     9900

aaatttgata tggactagtt tccctagaaa ttacatgcca tcacacatac aaaactatat     9960

agaacatgaa aaattaaaat tttccgagag tgataaatca agaagagtat tagagtatta    10020

tttaagagat aacaaattca atgaatgtga tttatacaac tgtgtagtta atcaaagtta    10080

tctcaacaac cctaatcatg tggtatcatt gacaggcaaa gaaagagaac tcagtgtagg    10140

tagaatgttt gcaatgcaac cgggaatgtt cagacaggtt caaatattgg cagagaaaat    10200

gatagctgaa aacattttac aattctttcc tgaaagtctt acaagatatg gtgatctaga    10260

actacaaaaa atattagaat tgaaagcagg aataagtaac aaatcaaatc gctacaatga    10320

taattacaac aattacatta gtaagtgctc tatcatcaca gatctcagca aattcaatca    10380

agcatttcga tatgaaacgt catgtatttg tagtgatgtg ctggatgaac tgcatggtgt    10440

acaatctcta ttttcctggt tacatttaac tattcctcat gtcacaataa tatgcacata    10500

taggcatgca cccccctata taggagatca tattgtagat cttaacaatg tagatgaaca    10560

aagtggatta tatagatatc acatgggtgg catcgaaggg tggtgtcaaa aactatggac    10620

catagaagct atatcactat tggatctaat atctctcaaa gggaaattct caattactgc    10680

tttaattaat ggtgacaatc aatcaataga tataagcaaa ccaatcagac tcatggaagg    10740

tcaaactcat gctcaagcag attatttgct agcattaaat agccttaaat tactgtataa    10800

agagtatgca ggcataggcc acaaattaaa aggaactgag acttatatat cacgagatat    10860

gcaatttatg agtaaaacaa ttcaacataa cggtgtatat tacccagcta gtataaagaa    10920

agtcctaaga gtgggaccgt ggataaacac tatacttgat gatttcaaag tgagtctaga    10980

atctataggt agtttgacac aagaattaga atatagaggt gaaagtctat tatgcagttt    11040

aatatttaga aatgtatggt tatataatca gattgctcta caattaaaaa atcatgcatt    11100

atgtaacaat aaactatatt tggacatatt aaaggttctg aaacacttaa aaaccttttt    11160

taatcttgat aatattgata cagcattaac attgtatatg aatttaccca tgttatttgg    11220

tggtggtgat cccaacttgt tatatcgaag tttctataga agaactcctg acttcctcac    11280

agaggctata gttcactctg tgttcatact tagttattat acaaaccatg acttaaaaga    11340

taaacttcaa gatctgtcag atgatagatt gaataagttc ttaacatgca taatcacgtt    11400

tgacaaaaac cctaatgctg aattcgtaac attgatgaga gatcctcaag ctttagggtc    11460

tgagagacaa gctaaaatta ctagcgaaat caatagactg gcagttacag aggttttgag    11520

tacagctcca aacaaaatat tctccaaaag tgcacaacat tatactacta cagagataga    11580

tctaaatgat attatgcaaa atatagaacc tacatatcct catgggctaa gagttgttta    11640

tgaaagttta cccttttata aagcagagaa aatagtaaat cttatatcag gtacaaaatc    11700

tataactaac atactggaaa aaacttctgc catagactta acagatattg atagagccac    11760

tgagatgatg aggaaaaaca taactttgct tataaggata cttccattgg attgtaacag    11820

agataaaaga gagatattga gtatggaaaa cctaagtatt actgaattaa gcaaatatgt    11880

tagggaaaga tcttggtctt tatccaatat agttggtgtt acatcaccca gtatcatgta    11940

tacaatggac atcaaatata ctacaagcac tatatctagt ggcataatta tagagaaata    12000

taatgttaac agtttaacac gtggtgagag aggacccact aaaccatggg ttggttcatc    12060

tacacaagag aaaaaaacaa tgccagttta taatagacaa gtcttaacca aaaaacagag    12120

agatcaaata gatctattag caaaattgga ttgggtgtat gcatctatag ataacaagga    12180

tgaattcatg gaagaactca gcataggaac ccttgggtta acatatgaaa aggccaagaa    12240

attatttcca caatatttaa gtgtcaatta tttgcatcgc cttacagtca gtagtagacc    12300

atgtgaattc cctgcatcaa taccagctta tagaacaaca aattatcact ttgacactag    12360

ccctattaat cgcatattaa cagaaaagta tggtgatgaa gatattgaca tagtattcca    12420

aaactgtata agctttggcc ttagtttaat gtcagtagta gaacaattta ctaatgtatg    12480

tcctaacaga attattctca tacctaagct taatgagata catttgatga aacctcccat    12540

attcacaggt gatgttgata ttcacaagtt aaaacaagtg atacaaaaac agcatatgtt    12600

tttaccagac aaaataagtt tgactcaata tgtggaatta ttcttaagta ataaaacact    12660

caaatctgga tctcatgtta attctaattt aatattggca cataaaatat ctgactattt    12720

tcataatact tacattttaa gtactaattt agctggacat tggattctga ttatacaact    12780

tatgaaagat tctaaaggta tttttgaaaa agattgggga gagggatata taactgatca    12840

tatgtttatt aatttgaaag ttttcttcaa tgcttataag acctatctct tgtgttttca    12900

taaaggttat ggcaaagcaa agctggagtg tgatatgaac acttcagatc ttctatgtgt    12960

attggaatta atagacagta gttattggaa gtctatgtct aaggtatttt tagaacaaaa    13020

agttatcaaa tacattctta gccaagatgc aagtttacat agagtaaaag gatgtcatag    13080

cttcaaatta tggtttctta aacgtcttaa tgtagcagaa ttcacagttt gcccttgggt    13140

tgttaacata gattatcatc caacacatat gaaagcaata ttaacttata tagatcttgt    13200

tagaatggga ttgataaata tagatagaat acacattaaa aataaacaca aattcaatga    13260

tgaattttat acttctaatc tcttctacat taattataac ttctcagata atactcatct    13320

attaactaaa catataagga ttgctaattc tgaattagaa aataattaca acaaattata    13380

tcatcctaca ccagaaacac tagagaatat actagccaat ccgattaaaa gtaatgacaa    13440

aaagacactg aatgactatt gtataggtaa aaatgttgac tcaataatgt taccattgtt    13500

atctaataag aagcttatta aatcgtctgc aatgattaga accaattaca gcaaacaaga    13560

tttgtataat ttattcccta tggttgtgat tgatagaatt atagatcatt caggcaatac    13620

agccaaatcc aaccaacttt acactactac ttcccaccaa atatctttag tgcacaatag    13680

cacatcactt tactgcatgc ttccttggca tcatattaat agattcaatt ttgtatttag    13740

ttctacaggt tgtaaaatta gtatagagta tattttaaaa gatcttaaaa ttaaagatcc    13800

caattgtata gcattcatag gtgaaggagc agggaattta ttattgcgta cagtagtgga    13860

acttcatcct gacataagat atatttacag aagtctgaaa gattgcaatg atcatagttt    13920

acctattgag tttttaaggc tgtacaatgg acatatcaac attgattatg gtgaaaattt    13980

gaccattcct gctacagatg caaccaacaa cattcattgg tcttatttac atataaagtt    14040

tgctgaacct atcagtcttt ttgtctgtga tgccgaattg tctgtaacag tcaactggag    14100

taaaattata atagaatgga gcaagcatgt aagaaagtgc aagtactgtt cctcagttaa    14160

taaatgtatg ttaatagtaa aatatcatgc tcaagatgat attgatttca aattagacaa    14220

tataactata ttaaaaactt atgtatgctt aggcagtaag ttaaagggat cggaggttta    14280

cttagtcctt acaataggtc ctgcgaatat attcccagta tttaatgtag tacaaaatgc    14340

taaattgata ctatcaagaa ccaaaaattt catcatgcct aagaaagctg ataaagagtc    14400

tattgatgca aatattaaaa gtttgatacc ctttctttgt taccctataa caaaaaaagg    14460

aattaatact gcattgtcaa aactaaagag tgttgttagt ggagatatac tatcatattc    14520

tatagctgga cgtaatgaag ttttcagcaa taaacttata aatcataagc atatgaacat    14580

cttaaaatgg ttcaatcatg ttttaaattt cagatcaaca gaactaaact ataaccattt    14640

atatatggta gaatctacat atccttacct aagtgaattg ttaaacagct tgacaaccaa    14700

tgaacttaaa aaactgatta aaatcacagg tagtctgtta tacaactttc ataatgaata    14760

atgaataaag atcttataat aaaaattccc atagctatac actaacactg tattcaatta    14820

tagttattaa aaattaaaaa tcatataatt ttttaaataa cttttagtga actaatccta    14880

aagttatcat tttaatcttg gaggaataaa tttaaaccct aatctaattg gtttatatgt    14940

gtattaacta aattacgaga tattagtttt tgacactttt tttctcgtgg ccggcatggt    15000

cccagcctcc tcgctggcgc cggctgggca acattccgag gggaccgtcc cctcggtaat    15060

ggcgaatggg acgtcgacag ctaacaaagc ccgaaggaag tgagttgctg ctgccaccgt    15120

tgagcaataa ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttgct    15180

gaaaggagtc gtggagacgt tgcgcgcccg cgggtcgacg cggccgcaag cttggcgtaa    15240

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata    15300

cgaccggaag cataaagtgt aaagcctg                                       15328


<210> 6
<211> 17912
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      nucleotide sequence of pUC19+ rA2deltaM2-2 plasmid 
      (used in rescue of recombinant virus)

<400> 6
acgggaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt       60

tgataagtac cacttaaatt taactccctt ggttagagat gggcagcaat tcattgagta      120

tgataaaagt tagattacaa aatttgtttg acaatgatga agtagcattg ttaaaaataa      180

catgctatac tgataaatta atacatttaa ctaatgcttt ggctaaggca gtgatacata      240

caatcaaatt gaatggcatt gtgtttgtgc atgttattac aagtagtgat atttgcccta      300

ataataatat tgtagtaaaa tccaatttca caacaatgcc agtactacaa aatggaggtt      360

atatatggga aatgatggaa ttaacacatt gctctcaacc taacggtcta ctagatgaca      420

attgtgaaat taaattctcc aaaaaactaa gtgattcaac aatgaccaat tatatgaatc      480

aattatctga attacttgga tttgatctta atccataaat tataattaat atcaactagc      540

aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc      600

aaataaatca attcagccaa cccaaccatg gacacaaccc acaatgataa tacaccacaa      660

agactgatga tcacagacat gagaccgttg tcacttgaga ccataataac atcactaacc      720

agagacatca taacacacaa atttatatac ttgataaatc atgaatgcat agtgagaaga      780

cttgatgaaa gacaggccac atttacattc ctggtcaact atgaaatgaa actattacac      840

aaagtaggaa gcactaaata taaaaaatat actgaataca acacaaaata tggcactttc      900

cctatgccaa tattcatcaa tcatgatggg ttcttagaat gcattggcat taagcctaca      960

aagcatactc ccataatata caagtatgat ctcaatccat aaatttcaac acaatattca     1020

cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa     1080

aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga     1140

tggctcttag caaagtcaag ttgaatgata cactcaacaa ggatcaactt ctgtcatcca     1200

gcaaatacgc catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc     1260

agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat     1320

tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa     1380

aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc     1440

gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa     1500

ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag     1560

aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat     1620

tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag     1680

ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac     1740

tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag     1800

atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag     1860

ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg     1920

gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa     1980

tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct     2040

accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct     2100

ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac     2160

cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg     2220

gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc     2280

agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa     2340

tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta     2400

aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata     2460

gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa     2520

attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt     2580

atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt     2640

ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt     2700

catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg     2760

atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac     2820

ctacatctgc tcgggatggt ataagagatg ccatggttgg tttaagagaa gaaatgatag     2880

aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca     2940

ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa     3000

catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg     3060

aagatttctg attagttacc aatcttcaca tcaacacaca ataccaacag aagaccaaca     3120

aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca     3180

aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa     3240

aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat     3300

acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa     3360

tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta     3420

atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga     3480

taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg     3540

tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg     3600

catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta     3660

tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa     3720

catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc     3780

tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa     3840

tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca     3900

aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa     3960

gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca     4020

tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac     4080

attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact     4140

tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt     4200

aataaaaaat atacacatgg ggcaaataat cattggagga aatccaacta atcacaatat     4260

ctgttaacat agacaagtcc acacaccata cagaatcaac caatggaaaa tacatccata     4320

acaatagaat tctcaagcaa attctggcct tactttacac taatacacat gatcacaaca     4380

ataatctctt tgctaatcat aatctccatc atgattgcaa tactaaacaa actttgtgaa     4440

tataacgtat tccataacaa aacctttgag ttaccaagag ctcgagtcaa cacatagcat     4500

tcatcaatcc aacagcccaa aacagtaacc ttgcatttaa aaatgaacaa cccctacctc     4560

tttacaacac ctcattaaca tcccaccatg caaaccacta tccatactat aaagtagtta     4620

attaaaaata gtcataacaa tgaactagga tatcaagact aacaataaca ttggggcaaa     4680

tgcaaacatg tccaaaaaca aggaccaacg caccgctaag acattagaaa ggacctggga     4740

cactctcaat catttattat tcatatcatc gtgcttatat aagttaaatc ttaaatctgt     4800

agcacaaatc acattatcca ttctggcaat gataatctca acttcactta taattgcagc     4860

catcatattc atagcctcgg caaaccacaa agtcacacca acaactgcaa tcatacaaga     4920

tgcaacaagc cagatcaaga acacaacccc aacatacctc acccagaatc ctcagcttgg     4980

aatcagtccc tctaatccgt ctgaaattac atcacaaatc accaccatac tagcttcaac     5040

aacaccagga gtcaagtcaa ccctgcaatc cacaacagtc aagaccaaaa acacaacaac     5100

aactcaaaca caacccagca agcccaccac aaaacaacgc caaaacaaac caccaagcaa     5160

acccaataat gattttcact ttgaagtgtt caactttgta ccctgcagca tatgcagcaa     5220

caatccaacc tgctgggcta tctgcaaaag aataccaaac aaaaaaccag gaaagaaaac     5280

cactaccaag cccacaaaaa aaccaaccct caagacaacc aaaaaagatc ccaaacctca     5340

aaccactaaa tcaaaggaag tacccaccac caagcccaca gaagagccaa ccatcaacac     5400

caccaaaaca aacatcataa ctacactact cacctccaac accacaggaa atccagaact     5460

cacaagtcaa atggaaacct tccactcaac ttcctccgaa ggcaatccaa gcccttctca     5520

agtctctaca acatccgagt acccatcaca accttcatct ccacccaaca caccacgcca     5580

gtagttactt aaaaacatat tatcacaaaa agccatgacc aacttaaaca gaatcaaagt     5640

aaactctggg gcaaataaca atggagttgc taatcctcaa agcaaatgca attaccacaa     5700

tcctcactgc agtcacattt tgttttgctt ctggtcaaaa catcactgaa gaattttatc     5760

aatcaacatg cagtgcagtt agcaaaggct atcttagtgc tctgagaact ggttggtata     5820

ccagtgttat aactatagaa ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg     5880

ctaaggtaaa attgataaaa caagaattag ataaatataa aaatgctgta acagaattgc     5940

agttgctcat gcaaagcaca caagcaacaa acaatcgagc cagaagagaa ctaccaaggt     6000

ttatgaatta tacactcaac aatgccaaaa aaaccaatgt aacattaagc aagaaaagga     6060

aaagaagatt tcttggtttt ttgttaggtg ttggatctgc aatcgccagt ggcgttgctg     6120

tatctaaggt cctgcaccta gaaggggaag tgaacaagat caaaagtgct ctactatcca     6180

caaacaaggc tgtagtcagc ttatcaaatg gagtcagtgt cttaaccagc aaagtgttag     6240

acctcaaaaa ctatatagat aaacaattgt tacctattgt gaacaagcaa agctgcagca     6300

tatcaaatat agaaactgtg atagagttcc aacaaaagaa caacagacta ctagagatta     6360

ccagggaatt tagtgttaat gcaggtgtaa ctacacctgt aagcacttac atgttaacta     6420

atagtgaatt attgtcatta atcaatgata tgcctataac aaatgatcag aaaaagttaa     6480

tgtccaacaa tgttcaaata gttagacagc aaagttactc tatcatgtcc ataataaaag     6540

aggaagtctt agcatatgta gtacaattac cactatatgg tgttatagat acaccctgtt     6600

ggaaactaca cacatcccct ctatgtacaa ccaacacaaa agaagggtcc aacatctgtt     6660

taacaagaac tgacagagga tggtactgtg acaatgcagg atcagtatct ttcttcccac     6720

aagctgaaac atgtaaagtt caatcaaatc gagtattttg tgacacaatg aacagtttaa     6780

cattaccaag tgaagtaaat ctctgcaatg ttgacatatt caaccccaaa tatgattgta     6840

aaattatgac ttcaaaaaca gatgtaagca gctccgttat cacatctcta ggagccattg     6900

tgtcatgcta tggcaaaact aaatgtacag catccaataa aaatcgtgga atcataaaga     6960

cattttctaa cgggtgcgat tatgtatcaa ataaaggggt ggacactgtg tctgtaggta     7020

acacattata ttatgtaaat aagcaagaag gtaaaagtct ctatgtaaaa ggtgaaccaa     7080

taataaattt ctatgaccca ttagtattcc cctctgatga atttgatgca tcaatatctc     7140

aagtcaacga gaagattaac cagagcctag catttattcg taaatccgat gaattattac     7200

ataatgtaaa tgccggtaaa tccaccacaa atatcatgat aactactata attatagtga     7260

ttatagtaat attgttatca ttaattgctg ttggactgct cttatactgt aaggccagaa     7320

gcacaccagt cacactaagc aaagatcaac tgagtggtat aaataatatt gcatttagta     7380

actaaataaa aatagcacct aatcatgttc ttacaatggt ttactatctg ctcatagaca     7440

acccatctgt cattggattt tcttaaaatc tgaacttcat tgaaactctc atctataaac     7500

catctcactt acactattta agtagattcc tagtttatag ttatataaaa cacaattgaa     7560

tgccagatta acttaccatc tgtaaaaatg aaaactgggg caaatatgtc acgaaggaat     7620

ccttgcaaat ttgaaattcg aggtcattgc ttaaatggta agaggtgtca ttttagtcat     7680

aattattttg aatggccacc gcatgcactg cttgtaagac aaaactttat gttaaacaga     7740

atacttaagt ctatggataa aagtatagat accttatcag aaataagtgg agctgcagag     7800

ttggacagaa cagaagagta tgctcttggt gtagttggag tgctagagag ttatatagga     7860

tcaataaaca atataactaa acaatcagca tgtgttgcca tgagcaaact cctcactgaa     7920

ctcaatagtg atgatatcaa aaagctgagg gacaatgaag agctaaattc acccaagata     7980

agagtgtaca atactgtcat atcatatatt gaaagcaaca ggaaaaacaa taaacaaact     8040

atccatctgt taaaaagatt gccagcagac gtattgaaga aaaccatcaa aaacacattg     8100

gatatccata agagcataac catcaacaac ccaaaagaat caactgttag tgatacaaat     8160

gaccatgcca aaaataatga tactacctga caaataagct tcaattctaa cactcaccac     8220

atcgttacat tattaattca aacaattcaa gttgtgggac aaaatggatc ccattattaa     8280

tggaaattct gctaatgttt atctaaccga tagttattta aaaggtgtta tctctttctc     8340

agagtgtaat gctttaggaa gttacatatt caatggtcct tatctcaaaa atgattatac     8400

caacttaatt agtagacaaa atccattaat agaacacatg aatctaaaga aactaaatat     8460

aacacagtcc ttaatatcta agtatcataa aggtgaaata aaattagaag aacctactta     8520

ttttcagtca ttacttatga catacaagag tatgacctcg tcagaacaga ttgctaccac     8580

taatttactt aaaaagataa taagaagagc tatagaaata agtgatgtca aagtctatgc     8640

tatattgaat aaactagggc ttaaagaaaa ggacaagatt aaatccaaca atggacaaga     8700

tgaagacaac tcagttatta cgaccataat caaagatgat atactttcag ctgttaaaga     8760

taatcaatct catcttaaag cagacaaaaa tcactctaca aaacaaaaag acacaatcaa     8820

aacaacactc ttgaagaaat tgatgtgttc aatgcaacat cctccatcat ggttaataca     8880

ttggtttaac ttatacacaa aattaaacaa catattaaca cagtatcgat caaatgaggt     8940

aaaaaaccat gggtttacat tgatagataa tcaaactctt agtggatttc aatttatttt     9000

gaaccaatat ggttgtatag tttatcataa ggaactcaaa agaattactg tgacaaccta     9060

taatcaattc ttgacatgga aagatattag ccttagtaga ttaaatgttt gtttaattac     9120

atggattagt aactgcttga acacattaaa taaaagctta ggcttaagat gcggattcaa     9180

taatgttatc ttgacacaac tattccttta tggagattgt atactaaagc tatttcacaa     9240

tgaggggttc tacataataa aagaggtaga gggatttatt atgtctctaa ttttaaatat     9300

aacagaagaa gatcaattca gaaaacgatt ttataatagt atgctcaaca acatcacaga     9360

tgctgctaat aaagctcaga aaaatctgct atcaagagta tgtcatacat tattagataa     9420

gacagtgtcc gataatataa taaatggcag atggataatt ctattaagta agttccttaa     9480

attaattaag cttgcaggtg acaataacct taacaatctg agtgaactat attttttgtt     9540

cagaatattt ggacacccaa tggtagatga aagacaagcc atggatgctg ttaaaattaa     9600

ttgcaatgag accaaatttt acttgttaag cagtctgagt atgttaagag gtgcctttat     9660

atatagaatt ataaaagggt ttgtaaataa ttacaacaga tggcctactt taagaaatgc     9720

tattgtttta cccttaagat ggttaactta ctataaacta aacacttatc cttctttgtt     9780

ggaacttaca gaaagagatt tgattgtgtt atcaggacta cgtttctatc gtgagtttcg     9840

gttgcctaaa aaagtggatc ttgaaatgat tataaatgat aaagctatat cacctcctaa     9900

aaatttgata tggactagtt tccctagaaa ttacatgcca tcacacatac aaaactatat     9960

agaacatgaa aaattaaaat tttccgagag tgataaatca agaagagtat tagagtatta    10020

tttaagagat aacaaattca atgaatgtga tttatacaac tgtgtagtta atcaaagtta    10080

tctcaacaac cctaatcatg tggtatcatt gacaggcaaa gaaagagaac tcagtgtagg    10140

tagaatgttt gcaatgcaac cgggaatgtt cagacaggtt caaatattgg cagagaaaat    10200

gatagctgaa aacattttac aattctttcc tgaaagtctt acaagatatg gtgatctaga    10260

actacaaaaa atattagaat tgaaagcagg aataagtaac aaatcaaatc gctacaatga    10320

taattacaac aattacatta gtaagtgctc tatcatcaca gatctcagca aattcaatca    10380

agcatttcga tatgaaacgt catgtatttg tagtgatgtg ctggatgaac tgcatggtgt    10440

acaatctcta ttttcctggt tacatttaac tattcctcat gtcacaataa tatgcacata    10500

taggcatgca cccccctata taggagatca tattgtagat cttaacaatg tagatgaaca    10560

aagtggatta tatagatatc acatgggtgg catcgaaggg tggtgtcaaa aactatggac    10620

catagaagct atatcactat tggatctaat atctctcaaa gggaaattct caattactgc    10680

tttaattaat ggtgacaatc aatcaataga tataagcaaa ccaatcagac tcatggaagg    10740

tcaaactcat gctcaagcag attatttgct agcattaaat agccttaaat tactgtataa    10800

agagtatgca ggcataggcc acaaattaaa aggaactgag acttatatat cacgagatat    10860

gcaatttatg agtaaaacaa ttcaacataa cggtgtatat tacccagcta gtataaagaa    10920

agtcctaaga gtgggaccgt ggataaacac tatacttgat gatttcaaag tgagtctaga    10980

atctataggt agtttgacac aagaattaga atatagaggt gaaagtctat tatgcagttt    11040

aatatttaga aatgtatggt tatataatca gattgctcta caattaaaaa atcatgcatt    11100

atgtaacaat aaactatatt tggacatatt aaaggttctg aaacacttaa aaaccttttt    11160

taatcttgat aatattgata cagcattaac attgtatatg aatttaccca tgttatttgg    11220

tggtggtgat cccaacttgt tatatcgaag tttctataga agaactcctg acttcctcac    11280

agaggctata gttcactctg tgttcatact tagttattat acaaaccatg acttaaaaga    11340

taaacttcaa gatctgtcag atgatagatt gaataagttc ttaacatgca taatcacgtt    11400

tgacaaaaac cctaatgctg aattcgtaac attgatgaga gatcctcaag ctttagggtc    11460

tgagagacaa gctaaaatta ctagcgaaat caatagactg gcagttacag aggttttgag    11520

tacagctcca aacaaaatat tctccaaaag tgcacaacat tatactacta cagagataga    11580

tctaaatgat attatgcaaa atatagaacc tacatatcct catgggctaa gagttgttta    11640

tgaaagttta cccttttata aagcagagaa aatagtaaat cttatatcag gtacaaaatc    11700

tataactaac atactggaaa aaacttctgc catagactta acagatattg atagagccac    11760

tgagatgatg aggaaaaaca taactttgct tataaggata cttccattgg attgtaacag    11820

agataaaaga gagatattga gtatggaaaa cctaagtatt actgaattaa gcaaatatgt    11880

tagggaaaga tcttggtctt tatccaatat agttggtgtt acatcaccca gtatcatgta    11940

tacaatggac atcaaatata ctacaagcac tatatctagt ggcataatta tagagaaata    12000

taatgttaac agtttaacac gtggtgagag aggacccact aaaccatggg ttggttcatc    12060

tacacaagag aaaaaaacaa tgccagttta taatagacaa gtcttaacca aaaaacagag    12120

agatcaaata gatctattag caaaattgga ttgggtgtat gcatctatag ataacaagga    12180

tgaattcatg gaagaactca gcataggaac ccttgggtta acatatgaaa aggccaagaa    12240

attatttcca caatatttaa gtgtcaatta tttgcatcgc cttacagtca gtagtagacc    12300

atgtgaattc cctgcatcaa taccagctta tagaacaaca aattatcact ttgacactag    12360

ccctattaat cgcatattaa cagaaaagta tggtgatgaa gatattgaca tagtattcca    12420

aaactgtata agctttggcc ttagtttaat gtcagtagta gaacaattta ctaatgtatg    12480

tcctaacaga attattctca tacctaagct taatgagata catttgatga aacctcccat    12540

attcacaggt gatgttgata ttcacaagtt aaaacaagtg atacaaaaac agcatatgtt    12600

tttaccagac aaaataagtt tgactcaata tgtggaatta ttcttaagta ataaaacact    12660

caaatctgga tctcatgtta attctaattt aatattggca cataaaatat ctgactattt    12720

tcataatact tacattttaa gtactaattt agctggacat tggattctga ttatacaact    12780

tatgaaagat tctaaaggta tttttgaaaa agattgggga gagggatata taactgatca    12840

tatgtttatt aatttgaaag ttttcttcaa tgcttataag acctatctct tgtgttttca    12900

taaaggttat ggcaaagcaa agctggagtg tgatatgaac acttcagatc ttctatgtgt    12960

attggaatta atagacagta gttattggaa gtctatgtct aaggtatttt tagaacaaaa    13020

agttatcaaa tacattctta gccaagatgc aagtttacat agagtaaaag gatgtcatag    13080

cttcaaatta tggtttctta aacgtcttaa tgtagcagaa ttcacagttt gcccttgggt    13140

tgttaacata gattatcatc caacacatat gaaagcaata ttaacttata tagatcttgt    13200

tagaatggga ttgataaata tagatagaat acacattaaa aataaacaca aattcaatga    13260

tgaattttat acttctaatc tcttctacat taattataac ttctcagata atactcatct    13320

attaactaaa catataagga ttgctaattc tgaattagaa aataattaca acaaattata    13380

tcatcctaca ccagaaacac tagagaatat actagccaat ccgattaaaa gtaatgacaa    13440

aaagacactg aatgactatt gtataggtaa aaatgttgac tcaataatgt taccattgtt    13500

atctaataag aagcttatta aatcgtctgc aatgattaga accaattaca gcaaacaaga    13560

tttgtataat ttattcccta tggttgtgat tgatagaatt atagatcatt caggcaatac    13620

agccaaatcc aaccaacttt acactactac ttcccaccaa atatctttag tgcacaatag    13680

cacatcactt tactgcatgc ttccttggca tcatattaat agattcaatt ttgtatttag    13740

ttctacaggt tgtaaaatta gtatagagta tattttaaaa gatcttaaaa ttaaagatcc    13800

caattgtata gcattcatag gtgaaggagc agggaattta ttattgcgta cagtagtgga    13860

acttcatcct gacataagat atatttacag aagtctgaaa gattgcaatg atcatagttt    13920

acctattgag tttttaaggc tgtacaatgg acatatcaac attgattatg gtgaaaattt    13980

gaccattcct gctacagatg caaccaacaa cattcattgg tcttatttac atataaagtt    14040

tgctgaacct atcagtcttt ttgtctgtga tgccgaattg tctgtaacag tcaactggag    14100

taaaattata atagaatgga gcaagcatgt aagaaagtgc aagtactgtt cctcagttaa    14160

taaatgtatg ttaatagtaa aatatcatgc tcaagatgat attgatttca aattagacaa    14220

tataactata ttaaaaactt atgtatgctt aggcagtaag ttaaagggat cggaggttta    14280

cttagtcctt acaataggtc ctgcgaatat attcccagta tttaatgtag tacaaaatgc    14340

taaattgata ctatcaagaa ccaaaaattt catcatgcct aagaaagctg ataaagagtc    14400

tattgatgca aatattaaaa gtttgatacc ctttctttgt taccctataa caaaaaaagg    14460

aattaatact gcattgtcaa aactaaagag tgttgttagt ggagatatac tatcatattc    14520

tatagctgga cgtaatgaag ttttcagcaa taaacttata aatcataagc atatgaacat    14580

cttaaaatgg ttcaatcatg ttttaaattt cagatcaaca gaactaaact ataaccattt    14640

atatatggta gaatctacat atccttacct aagtgaattg ttaaacagct tgacaaccaa    14700

tgaacttaaa aaactgatta aaatcacagg tagtctgtta tacaactttc ataatgaata    14760

atgaataaag atcttataat aaaaattccc atagctatac actaacactg tattcaatta    14820

tagttattaa aaattaaaaa tcatataatt ttttaaataa cttttagtga actaatccta    14880

aagttatcat tttaatcttg gaggaataaa tttaaaccct aatctaattg gtttatatgt    14940

gtattaacta aattacgaga tattagtttt tgacactttt tttctcgtgg ccggcatggt    15000

cccagcctcc tcgctggcgc cggctgggca acattccgag gggaccgtcc cctcggtaat    15060

ggcgaatggg acgtcgacag ctaacaaagc ccgaaggaag tgagttgctg ctgccaccgt    15120

tgagcaataa ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttgct    15180

gaaaggagtc gtggagacgt tgcgcgcccg cgggtcgacg cggccgcaag cttggcgtaa    15240

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata    15300

cgaccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa    15360

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat    15420

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc    15480

tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg    15540

cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag    15600

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc    15660

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag    15720

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga    15780

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc    15840

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg    15900

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt    15960

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca    16020

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca    16080

ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag    16140

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca    16200

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg    16260

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa    16320

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta    16380

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag    16440

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga    16500

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac    16560

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc    16620

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta    16680

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac    16740

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat    16800

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa    16860

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg    16920

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag    16980

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc    17040

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct    17100

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat    17160

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg    17220

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc    17280

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta    17340

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg    17400

tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc acgaggccct    17460

ttcgtctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag ctcccggaga    17520

cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag ggcgcgtcag    17580

cgggtgttgg cgggtgtcgg ggctggctta actatgcggc atcagagcag attgtactga    17640

gagtgcacca tatgcggtgt gaaataccgc acagatgcgt aaggagaaaa taccgcatca    17700

ggcgccattc gccattcagg ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt    17760

cgctattacg ccagctggcg aaagggggat gtgctgcaag gcgattaagt tgggtaacgc    17820

cagggttttc ccagtcacga cgttgtaaaa cgacggccag tgaattcgtt aaaccggccg    17880

ggtacccccg ggtaatacga ctcactatag gg                                  17912


