                         SEQUENCE LISTING

<110>  MEDICENNA BIOPHARMA INC
       MERCHANT, Fahar
 
<120>  INTERLEUKIN-4 RECEPTOR-BINDING FUSION PROTEINS AND USES THEREOF

<130>  PAT 102517W-90

<150>  US 61/881,931
<151>  2013-09-24

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 including an additional methionine at the N-terminus

<400>  1

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser 
    130 


<210>  2
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4 including an additional methionine at the N-terminus

<400>  2

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser 
    130 


<210>  3
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted  IL-4

<400>  3

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  4
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted "RGA" IL-4 variant

<400>  4

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  5
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted "KFR" IL-4 variant

<400>  5

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser 
    130                 


<210>  6
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted "KF" IL-4 variant

<400>  6

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Lys Cys Ser Ser Gly Gly Asn Gly 
                85                  90                  95      


Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
            100                 105                 110         


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
        115                 120                 125             


Ile Phe Ala Ala Ser 
    130             


<210>  7
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-13 including an additional methionine at the N-terminus

<400>  7

Met Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Gln 
            100                 105                 110         


Phe Asn 
        


<210>  8
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "A11" variant IL-13

<400>  8

Met Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Arg Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln 
            100                 105                 110         


Phe Asn 
        


<210>  9
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "DN" variant IL-13

<400>  9

Met Pro Gly Pro Val Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu 
1               5                   10                  15      


Glu Leu Ile Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu Phe Arg Glu Gly Gln 
            100                 105                 110         


Phe Asn 
        


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13

<400>  10

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Leu Thr Ala Gly 
        115         


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13

<400>  11

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Leu Thr Ala Gly 
        115             


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13 "A11" variant

<400>  12

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu Leu Ile Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Arg Thr Ala Gly 
        115         


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13

<400>  13

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Val Arg Glu Leu Ile Glu Glu Leu Ile Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Arg Thr Ala Gly 
        115             


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permuted IL-13 "DN" variant

<400>  14

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Pro Gly Pro Val Pro 
65                  70                  75                  80  


Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu Leu Ile Asn Ile Thr 
                85                  90                  95      


Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile 
            100                 105                 110         


Asn Leu Thr Ala Gly 
        115         


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circular permuted IL-13

<400>  15

Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser 
1               5                   10                  15      


Ala Ile Glu Lys Thr Gln Asp Met Leu Ser Gly Phe Cys Pro His Lys 
            20                  25                  30          


Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ala Gln Phe Val Lys Asp Leu Leu Phe His Leu Arg Thr Leu 
    50                  55                  60                  


Phe Arg Glu Gly Gln Phe Asn Gly Gly Ser Gly Met Pro Gly Pro Val 
65                  70                  75                  80  


Pro Pro Ser Thr Ala Val Arg Ala Leu Ile Glu Glu Leu Ile Asn Ile 
                85                  90                  95      


Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser 
            100                 105                 110         


Ile Asn Leu Thr Ala Gly 
        115             


<210>  16
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser Ser 
1               5                   10                  15      


Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser Gly 
            20                  25                  30          


Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala Ser 
        35                  40                  45              


His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala Gly 
    50                  55                  60                  


Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr Glu 
65                  70                  75                  80  


Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser 
                85                  90                  95      


Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu 
            100                 105                 110         


Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu 
        115                 120                 125             


Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser Ser 
    130                 135                 140                 


Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly Arg 
145                 150                 155                 160 


Gly Ser Ser Ala Pro Ser Gln 
                165         


<210>  17
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant Bad

<400>  17

Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser Ser 
1               5                   10                  15      


Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser Gly 
            20                  25                  30          


Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala Ser 
        35                  40                  45              


His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala Gly 
    50                  55                  60                  


Ala Val Glu Ile Arg Ser Arg His Ser Ala Tyr Pro Ala Gly Thr Glu 
65                  70                  75                  80  


Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser 
                85                  90                  95      


Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu 
            100                 105                 110         


Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu 
        115                 120                 125             


Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser Ser 
    130                 135                 140                 


Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly Arg 
145                 150                 155                 160 


Gly Ser Ser Ala Pro Ser Gln 
                165         


<210>  18
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser Ser 
1               5                   10                  15      


Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser Gly 
            20                  25                  30          


Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala Ser 
        35                  40                  45              


His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala Gly 
    50                  55                  60                  


Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr Glu 
65                  70                  75                  80  


Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser 
                85                  90                  95      


Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu 
            100                 105                 110         


Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu 
        115                 120                 125             


Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser Ser 
    130                 135                 140                 


Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly Arg 
145                 150                 155                 160 


Gly Ser Ser Ala Pro Ser Gln 
                165         


<210>  19
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  19

Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser Ser 
1               5                   10                  15      


Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser Gly 
            20                  25                  30          


Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala Ser 
        35                  40                  45              


His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala Gly 
    50                  55                  60                  


Ala Val Glu Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr Glu 
65                  70                  75                  80  


Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser 
                85                  90                  95      


Arg Ser Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu 
            100                 105                 110         


Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu 
        115                 120                 125             


Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser Ser 
    130                 135                 140                 


Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly Arg 
145                 150                 155                 160 


Gly Ser Ser Ala Pro Ser Gln 
                165         


<210>  20
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Glu Val Arg Pro Leu Ser Arg Asp Ile Leu Met Glu Thr Leu Leu 
1               5                   10                  15      


Tyr Glu Gln Leu Leu Glu Pro Pro Thr Met Glu Val Leu Gly Met Thr 
            20                  25                  30          


Asp Ser Glu Glu Asp Leu Asp Pro Met Glu Asp Phe Asp Ser Leu Glu 
        35                  40                  45              


Cys Met Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Cys Ile Gly 
    50                  55                  60                  


Asp Glu Met Asp Val Ser Leu Arg Ala Pro Arg Leu Ala Gln Leu Ser 
65                  70                  75                  80  


Glu Val Ala Met His Ser Leu Gly Leu Ala Phe Ile Tyr Asp Gln Thr 
                85                  90                  95      


Glu Asp Ile Arg Asp Val Leu Arg Ser Phe Met Asp Gly Phe Thr Thr 
            100                 105                 110         


Leu Lys Glu Asn Ile Met Arg Phe Trp Arg Ser Pro Asn Pro Gly Ser 
        115                 120                 125             


Trp Val Ser Cys Glu Gln Val Leu Leu Ala Leu Leu Leu Leu Leu Ala 
    130                 135                 140                 


Leu Leu Leu Pro Leu Leu Ser Gly Gly Leu His Leu Leu Leu Lys 
145                 150                 155                 


<210>  21
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile Thr 
1               5                   10                  15      


Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser Phe 
            20                  25                  30          


Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala Pro 
        35                  40                  45              


Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser Ser 
    50                  55                  60                  


His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu Asp 
65                  70                  75                  80  


Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met 
                85                  90                  95      


Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln Leu 
            100                 105                 110         


Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala Thr 
        115                 120                 125             


Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu 
    130                 135                 140                 


Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser 
145                 150                 155                 160 


His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn Phe 
                165                 170                 175     


Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn Gly 
            180                 185                 190         


Met Asp 
        


<210>  22
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Lys Gln Pro Ser Asp Val Ser Ser Glu Cys Asp Arg Glu Gly Arg 
1               5                   10                  15      


Gln Leu Gln Pro Ala Glu Arg Pro Pro Gln Leu Arg Pro Gly Ala Pro 
            20                  25                  30          


Thr Ser Leu Gln Thr Glu Pro Gln Gly Asn Pro Glu Gly Asn His Gly 
        35                  40                  45              


Gly Glu Gly Asp Ser Cys Pro His Gly Ser Pro Gln Gly Pro Leu Ala 
    50                  55                  60                  


Pro Pro Ala Ser Pro Gly Pro Phe Ala Thr Arg Ser Pro Leu Phe Ile 
65                  70                  75                  80  


Phe Met Arg Arg Ser Ser Leu Leu Ser Arg Ser Ser Ser Gly Tyr Phe 
                85                  90                  95      


Ser Phe Asp Thr Asp Arg Ser Pro Ala Pro Met Ser Cys Asp Lys Ser 
            100                 105                 110         


Thr Gln Thr Pro Ser Pro Pro Cys Gln Ala Phe Asn His Tyr Leu Ser 
        115                 120                 125             


Ala Met Ala Ser Met Arg Gln Ala Glu Pro Ala Asp Met Arg Pro Glu 
    130                 135                 140                 


Ile Trp Ile Ala Gln Glu Leu Arg Arg Ile Gly Asp Glu Phe Asn Ala 
145                 150                 155                 160 


Tyr Tyr Ala Arg Arg Val Phe Leu Asn Asn Tyr Gln Ala Ala Glu Asp 
                165                 170                 175     


His Pro Arg Met Val Ile Leu Arg Leu Leu Arg Tyr Ile Val Arg Leu 
            180                 185                 190         


Val Trp Arg Met His 
        195         


<210>  23
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Pro Cys Pro Leu His Arg Gly Arg Gly Pro Pro Ala Val Cys Ala 
1               5                   10                  15      


Cys Ser Ala Gly Arg Leu Gly Leu Arg Ser Ser Ala Ala Gln Leu Thr 
            20                  25                  30          


Ala Ala Arg Leu Lys Ala Leu Gly Asp Glu Leu His Gln Arg Thr Met 
        35                  40                  45              


Trp Arg Arg Arg Ala Arg Ser Arg Arg Ala Pro Ala Pro Gly Ala Leu 
    50                  55                  60                  


Pro Thr Tyr Trp Pro Trp Leu Cys Ala Ala Ala Gln Val Ala Ala Leu 
65                  70                  75                  80  


Ala Ala Trp Leu Leu Gly Arg Arg Asn 
                85                  


<210>  24
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4-Bad fusion

<400>  24

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser 
    130                 135                 140                 


Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro 
145                 150                 155                 160 


Ser Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp 
                165                 170                 175     


Ala Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly 
            180                 185                 190         


Ala Gly Ala Val Glu Ile Arg Ser Arg His Ser Ala Tyr Pro Ala Gly 
        195                 200                 205             


Thr Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly 
    210                 215                 220                 


Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly 
225                 230                 235                 240 


Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys 
                245                 250                 255     


Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln 
            260                 265                 270         


Ser Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu 
        275                 280                 285             


Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295         


<210>  25
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpIL4-Bad fusion

<400>  25

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 300             


<210>  26
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpKFR4-Bad fusion

<400>  26

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 300             


<210>  27
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpS4-Bad fusion

<400>  27

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln 
    290                 295                 300             


<210>  28
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ubiquitin linker sequence

<400>  28

Gly Gly Gly Ser Met Gln Ile Phe Val Arg Thr Leu Thr Gly Arg Thr 
1               5                   10                  15      


Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Arg Ala 
            20                  25                  30          


Arg Ile Gln Asp Arg Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile 
        35                  40                  45              


Phe Ala Gly Arg Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn 
    50                  55                  60                  


Ile Gln Arg Glu Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75                  80  


Gly Ser 
        


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  29

Ala Ser Gly Gly Pro Glu 
1               5       


<210>  30
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-4

<400>  30
atgcacaaat gcgacattac cctgcaagag atcattaaga ccctgaacag cctgaccgag       60

caaaagaccc tgtgtaccga actgaccgtc acggacatct tcgctgcgtc caaggacact      120

acggaaaagg aaacgttctg tcgtgcggcg acggtgctgc gccagttcta cagccaccat      180

gagaaagata cccgttgcct cggtgcgacc gcgcaacagt tccaccgtca caaacagctg      240

attcgcttcc tgaagcgtct ggatcgcaac ctgtggggtt tggcgggtct gaactcctgt      300

ccagtcaaag aagccaatca gtctacgctg gaaaactttt tggagcgtct gaaaactatc      360

atgcgtgaga agtacagcaa atgcagcagc                                       390


<210>  31
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL4

<400>  31
atggatacca ccgagaaaga aacgttctgc cgtgctgcca ctgtcctgcg ccagttttac       60

agccatcacg aaaaggacac ccgttgcctg ggtgcgacgg cgcagcaatt ccaccgccac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgtaacc tgtggggtct ggcgggtctg      180

aacagctgtc cagtgaaaga agcgaatcag agcaccttgg agaatttcct cgaacgcctg      240

aaaaccatca tgcgtgagaa atacagcaag tgttctagcg gcggtaacgg tggccacaaa      300

tgcgatatca ccctgcaaga gatcattaag acgctgaact ccttgacgga acaaaagacc      360

ctgtgtactg agctgacggt caccgacatt ttcgcggcgt cc                         402


<210>  32
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpKFR

<400>  32
atggatacta ccgagaaaga aacgttttgc cgtgctgcga ccgtcctgcg tcagttctac       60

agccaccacg aaaaggacac ccgctgtctg ggtgcgactg cccaacaatt ccatcgtcac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgcaacc tgtggggtct ggcgggcttg      180

aactcctgcc cagtcaaaga agcgaaccaa agcaccctgg aaaacttctt ggagcgtctg      240

aaaacgatca tgaaagagaa gttccgcaag tgtagcagcg gtggtaatgg tggccacaag      300

tgcgacatta cgctgcagga aatcattaag accctgaact ctctgaccga gcagaaaacc      360

ctctgtaccg agctgacggt gacggatatc tttgcggcga gc                         402


<210>  33
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpS4

<400>  33
atggatacca ccgaaaaaga aactttttgt cgtgccgcga ctgtcctgcg ccagttctac       60

agccaccacg aaaaggacac ccgttgcctg ggtgcgaccg ctcaacaatt ccatcgccac      120

aaacagctga ttcgtttcct gaaacgtctg gatcgcaacc tgtggggtct ggcgggtttg      180

aacagctgtc cagtcaaaga agcgaaccag agcaccctgg aaaactttct ggagcgtctg      240

cgtgttatca tgcagagcaa gtggttcaag tgcggtgcgg gtggcaatgg tggccacaag      300

tgtgacatta ccttgcaaga gattatcaaa acgctgaact ctctgaccga gcaaaagacg      360

ctgtgcaccg agctgacggt gacggacatc ttcgcggcgt cc                         402


<210>  34
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pro-apoptotic Bcl-2 family member nucleic acid molecule, variant 
       BAD

<400>  34
ggtagctttc agatcccgga atttgagccg agcgagcaag aggattcaag cagcgcggag       60

cgcggtctgg gtccgagccc ggcaggcgac ggtccgagcg gcagcggcaa gcatcaccgc      120

caggcgccag gcctgctgtg ggatgcatcg catcaacagg aacaaccgac gagcagcagc      180

catcatggtg gcgctggtgc ggttgagatt agatcgcgcc actccgcata tcctgccggc      240

accgaagatg acgaaggcat gggcgaggaa ccgagcccgt tccgtggccg tagccgtgct      300

gcaccgccga atctgtgggc cgcacagcgt tatggtcgcg agttgcgtcg catgtccgac      360

gagtttgttg actccttcaa gaaaggttta ccgcgtccga aatctgccgg taccgcgacg      420

cagatgcgtc agagcagcag ctggacccgc gtgtttcaat cttggtggga tcgtaatctg      480

ggtcgtggta gcagcgcacc gagccaa                                          507


<210>  35
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-4-Bad fusion

<400>  35
atgcacaaat gcgacattac cctgcaagag atcattaaga ccctgaacag cctgaccgag       60

caaaagaccc tgtgtaccga actgaccgtc acggacatct tcgctgcgtc caaggacact      120

acggaaaagg aaacgttctg tcgtgcggcg acggtgctgc gccagttcta cagccaccat      180

gagaaagata cccgttgcct cggtgcgacc gcgcaacagt tccaccgtca caaacagctg      240

attcgcttcc tgaagcgtct ggatcgcaac ctgtggggtt tggcgggtct gaactcctgt      300

ccagtcaaag aagccaatca gtctacgctg gaaaactttt tggagcgtct gaaaactatc      360

atgcgtgaga agtacagcaa atgcagcagc ggtagctttc agatcccgga atttgagccg      420

agcgagcaag aggattcaag cagcgcggag cgcggtctgg gtccgagccc ggcaggcgac      480

ggtccgagcg gcagcggcaa gcatcaccgc caggcgccag gcctgctgtg ggatgcatcg      540

catcaacagg aacaaccgac gagcagcagc catcatggtg gcgctggtgc ggttgagatt      600

agatcgcgcc actccgcata tcctgccggc accgaagatg acgaaggcat gggcgaggaa      660

ccgagcccgt tccgtggccg tagccgtgct gcaccgccga atctgtgggc cgcacagcgt      720

tatggtcgcg agttgcgtcg catgtccgac gagtttgttg actccttcaa gaaaggttta      780

ccgcgtccga aatctgccgg taccgcgacg cagatgcgtc agagcagcag ctggacccgc      840

gtgtttcaat cttggtggga tcgtaatctg ggtcgtggta gcagcgcacc gagccaa         897


<210>  36
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL4-Bad fusion

<400>  36
atggatacca ccgagaaaga aacgttctgc cgtgctgcca ctgtcctgcg ccagttttac       60

agccatcacg aaaaggacac ccgttgcctg ggtgcgacgg cgcagcaatt ccaccgccac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgtaacc tgtggggtct ggcgggtctg      180

aacagctgtc cagtgaaaga agcgaatcag agcaccttgg agaatttcct cgaacgcctg      240

aaaaccatca tgcgtgagaa atacagcaag tgttctagcg gcggtaacgg tggccacaaa      300

tgcgatatca ccctgcaaga gatcattaag acgctgaact ccttgacgga acaaaagacc      360

ctgtgtactg agctgacggt caccgacatt ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaa                                                              909


<210>  37
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpKFR4-Bad fusion

<400>  37
atggatacta ccgagaaaga aacgttttgc cgtgctgcga ccgtcctgcg tcagttctac       60

agccaccacg aaaaggacac ccgctgtctg ggtgcgactg cccaacaatt ccatcgtcac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgcaacc tgtggggtct ggcgggcttg      180

aactcctgcc cagtcaaaga agcgaaccaa agcaccctgg aaaacttctt ggagcgtctg      240

aaaacgatca tgaaagagaa gttccgcaag tgtagcagcg gtggtaatgg tggccacaag      300

tgcgacatta cgctgcagga aatcattaag accctgaact ctctgaccga gcagaaaacc      360

ctctgtaccg agctgacggt gacggatatc tttgcggcga gcggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaa                                                              909


<210>  38
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpS4-Bad fusion

<400>  38
atggatacca ccgaaaaaga aactttttgt cgtgccgcga ctgtcctgcg ccagttctac       60

agccaccacg aaaaggacac ccgttgcctg ggtgcgaccg ctcaacaatt ccatcgccac      120

aaacagctga ttcgtttcct gaaacgtctg gatcgcaacc tgtggggtct ggcgggtttg      180

aacagctgtc cagtcaaaga agcgaaccag agcaccctgg aaaactttct ggagcgtctg      240

cgtgttatca tgcagagcaa gtggttcaag tgcggtgcgg gtggcaatgg tggccacaag      300

tgtgacatta ccttgcaaga gattatcaaa acgctgaact ctctgaccga gcaaaagacg      360

ctgtgcaccg agctgacggt gacggacatc ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaa                                                              909


<210>  39
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpIL-4-Bad

<400>  39
atgcacaaat gcgacattac cctgcaagag atcattaaga ccctgaacag cctgaccgag       60

caaaagaccc tgtgtaccga actgaccgtc acggacatct tcgctgcgtc caaggacact      120

acggaaaagg aaacgttctg tcgtgcggcg acggtgctgc gccagttcta cagccaccat      180

gagaaagata cccgttgcct cggtgcgacc gcgcaacagt tccaccgtca caaacagctg      240

attcgcttcc tgaagcgtct ggatcgcaac ctgtggggtt tggcgggtct gaactcctgt      300

ccagtcaaag aagccaatca gtctacgctg gaaaactttt tggagcgtct gaaaactatc      360

atgcgtgaga agtacagcaa atgcagcagc ggtagctttc agatcccgga atttgagccg      420

agcgagcaag aggattcaag cagcgcggag cgcggtctgg gtccgagccc ggcaggcgac      480

ggtccgagcg gcagcggcaa gcatcaccgc caggcgccag gcctgctgtg ggatgcatcg      540

catcaacagg aacaaccgac gagcagcagc catcatggtg gcgctggtgc ggttgagatt      600

agatcgcgcc actccgcata tcctgccggc accgaagatg acgaaggcat gggcgaggaa      660

ccgagcccgt tccgtggccg tagccgtgct gcaccgccga atctgtgggc cgcacagcgt      720

tatggtcgcg agttgcgtcg catgtccgac gagtttgttg actccttcaa gaaaggttta      780

ccgcgtccga aatctgccgg taccgcgacg cagatgcgtc agagcagcag ctggacccgc      840

gtgtttcaat cttggtggga tcgtaatctg ggtcgtggta gcagcgcacc gagccaacac      900

caccatcacc atcactaa                                                    918


<210>  40
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4-Bad

<400>  40

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu 
    130                 135                 140                 


Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp 
145                 150                 155                 160 


Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu 
                165                 170                 175     


Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His 
            180                 185                 190         


Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His Ser Ala Tyr Pro 
        195                 200                 205             


Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe 
    210                 215                 220                 


Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg 
225                 230                 235                 240 


Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe 
                245                 250                 255     


Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met 
            260                 265                 270         


Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg 
        275                 280                 285             


Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His His His His His 
    290                 295                 300                 


His 
305 


<210>  41
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bp cpIL-4-Bad

<400>  41
atggatacca ccgagaaaga aacgttctgc cgtgctgcca ctgtcctgcg ccagttttac       60

agccatcacg aaaaggacac ccgttgcctg ggtgcgacgg cgcagcaatt ccaccgccac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgtaacc tgtggggtct ggcgggtctg      180

aacagctgtc cagtgaaaga agcgaatcag agcaccttgg agaatttcct cgaacgcctg      240

aaaaccatca tgcgtgagaa atacagcaag tgttctagcg gcggtaacgg tggccacaaa      300

tgcgatatca ccctgcaaga gatcattaag acgctgaact ccttgacgga acaaaagacc      360

ctgtgtactg agctgacggt caccgacatt ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaac accaccatca ccatcac                                          927


<210>  42
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpIL-4-Bad

<400>  42

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His 
    290                 295                 300                 


His His His His His 
305                 


<210>  43
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bp cpS4-Bad

<400>  43
atggatacca ccgaaaaaga aactttttgt cgtgccgcga ctgtcctgcg ccagttctac       60

agccaccacg aaaaggacac ccgttgcctg ggtgcgaccg ctcaacaatt ccatcgccac      120

aaacagctga ttcgtttcct gaaacgtctg gatcgcaacc tgtggggtct ggcgggtttg      180

aacagctgtc cagtcaaaga agcgaaccag agcaccctgg aaaactttct ggagcgtctg      240

cgtgttatca tgcagagcaa gtggttcaag tgcggtgcgg gtggcaatgg tggccacaag      300

tgtgacatta ccttgcaaga gattatcaaa acgctgaact ctctgaccga gcaaaagacg      360

ctgtgcaccg agctgacggt gacggacatc ttcgcggcgt ccggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaac accaccatca ccatcactaa                                       930


<210>  44
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpS4-Bad

<400>  44

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Arg Val Ile Met Gln Ser Lys Trp Phe Lys Cys Gly Ala Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His 
    290                 295                 300                 


His His His His His 
305                 


<210>  45
<211>  926
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bp pKFR4-Bad-H6

<400>  45
atggatacta ccgagaaaga aacgttttgc cgtgctgcga ccgtcctgcg tcagttctac       60

agccaccacg aaaaggacac ccgctgtctg ggtgcgactg cccaacaatt ccatcgtcac      120

aaacagctga ttcgtttcct gaagcgtctg gaccgcaacc tgtggggtct ggcgggcttg      180

aactcctgcc cagtcaaaga agcgaaccaa agcaccctgg aaaacttctt ggagcgtctg      240

aaaacgatca tgaaagagaa gttccgcaag tgtagcagcg gtggtaatgg tggccacaag      300

tgcgacatta cgctgcagga aatcattaag accctgaact ctctgaccga gcagaaaacc      360

ctctgtaccg agctgacggt gacggatatc tttgcggcga gcggtagctt tcagatcccg      420

gaatttgagc cgagcgagca agaggattca agcagcgcgg agcgcggtct gggtccgagc      480

ccggcaggcg acggtccgag cggcagcggc aagcatcacc gccaggcgcc aggcctgctg      540

tgggatgcat cgcatcaaca ggaacaaccg acgagcagca gccatcatgg tggcgctggt      600

gcggttgaga ttagatcgcg ccactccgca tatcctgccg gcaccgaaga tgacgaaggc      660

atgggcgagg aaccgagccc gttccgtggc cgtagccgtg ctgcaccgcc gaatctgtgg      720

gccgcacagc gttatggtcg cgagttgcgt cgcatgtccg acgagtttgt tgactccttc      780

aagaaaggtt taccgcgtcc gaaatctgcc ggtaccgcga cgcagatgcg tcagagcagc      840

agctggaccc gcgtgtttca atcttggtgg gatcgtaatc tgggtcgtgg tagcagcgca      900

ccgagccaac accaccatca ccatca                                           926


<210>  46
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pKFR4-Bad-H6

<400>  46

Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
1               5                   10                  15      


Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
            20                  25                  30          


Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
        35                  40                  45              


Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
    50                  55                  60                  


Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Lys Thr Ile Met Lys Glu Lys Phe Arg Lys Cys Ser Ser Gly Gly Asn 
                85                  90                  95      


Gly Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu 
            100                 105                 110         


Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr 
        115                 120                 125             


Asp Ile Phe Ala Ala Ser Gly Ser Phe Gln Ile Pro Glu Phe Glu Pro 
    130                 135                 140                 


Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg Gly Leu Gly Pro Ser 
145                 150                 155                 160 


Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys His His Arg Gln Ala 
                165                 170                 175     


Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln Glu Gln Pro Thr Ser 
            180                 185                 190         


Ser Ser His His Gly Gly Ala Gly Ala Val Glu Ile Arg Ser Arg His 
        195                 200                 205             


Ser Ala Tyr Pro Ala Gly Thr Glu Asp Asp Glu Gly Met Gly Glu Glu 
    210                 215                 220                 


Pro Ser Pro Phe Arg Gly Arg Ser Arg Ala Ala Pro Pro Asn Leu Trp 
225                 230                 235                 240 


Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg Met Ser Asp Glu Phe 
                245                 250                 255     


Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro Lys Ser Ala Gly Thr 
            260                 265                 270         


Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr Arg Val Phe Gln Ser 
        275                 280                 285             


Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Ser Ala Pro Ser Gln His 
    290                 295                 300                 


His His His His His 
305                 


