                         SEQUENCE LISTING

<110>  Brigham Young University
 
<120>  USE OF COX-3 BINDING MOLECULES FOR MODULATING AUTOPHAGY

<130>  BYUV-003-WO1

<140>  PCT/US2014/058888
<141>  2014-10-02

<150>  US 61/960,988
<151>  2013-10-02

<150>  US 61/996,944
<151>  2014-05-19

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  DNA
<213>  Rat

<400>  1
agaagagcca gccgttggcg ttgcacatcc atc                                    33


<210>  2
<211>  39
<212>  DNA
<213>  Rat

<400>  2
aacaccagaa gagccagccg ttggcgttgc acatccatc                              39


<210>  3
<211>  50
<212>  DNA
<213>  Rat

<400>  3
agtgctggag taacaccaga agagccagcc gttggcgttg cacatccatc                  50


<210>  4
<211>  11
<212>  DNA
<213>  Rat

<400>  4
gcacatccat c                                                            11


<210>  5
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  predicted COX3 protein

<400>  5

Met Ser Arg Glu Ser Asp Pro Ser Gly Ala Pro Thr Arg Pro Gly Ile 
1               5                   10                  15      


Arg Trp Pro Ala Gly Gly Ala Leu Asn Val Arg Leu Asn Ser Leu Phe 
            20                  25                  30          


Pro Leu Gln Glu Gly Val Ser Arg Ser Ser Phe Pro Cys Cys Cys Ser 
        35                  40                  45              


Cys Cys Cys Ser His His Pro Arg Tyr Cys Ser Gln Met Leu Gly Tyr 
    50                  55                  60                  


Pro His Gln Ser Ile Pro Val Val Thr Ile His Ala Arg Thr Arg Val 
65                  70                  75                  80  


Ser Val Ser Ala Ser Ala Ser Thr Thr Thr Asn Val Thr Val Leu Ala 
                85                  90                  95      


Arg Ala Thr Arg Ala Pro Thr Val Leu Ser Leu Arg Ser Gly Pro Gly 
            100                 105                 110         


Phe Gly Val Pro Cys Gly Pro Ala Pro His Ser Pro Ile Ser Cys 
        115                 120                 125         


<210>  6
<211>  631
<212>  PRT
<213>  Artificial

<220>
<223>  predicted COX3 protein

<400>  6

Val Arg Pro Gln Arg Cys Pro His Ala Pro Arg Asn Ser Val Ala Cys 
1               5                   10                  15      


Arg Arg Ser Leu Glu Arg Gln Ala Gln Leu Ser Leu Pro Ser Ala Arg 
            20                  25                  30          


Arg Ser Leu Ser Leu Gln Phe Pro Leu Leu Leu Leu Leu Leu Leu Leu 
        35                  40                  45              


Pro Pro Pro Pro Val Leu Leu Thr Asp Ala Gly Val Pro Ser Pro Val 
    50                  55                  60                  


Asn Pro Cys Cys Tyr Tyr Pro Cys Gln Asn Gln Gly Val Cys Val Arg 
65                  70                  75                  80  


Phe Gly Leu Asp His Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 
                85                  90                  95      


Gly Pro Asn Cys Thr Ile Pro Glu Ile Trp Thr Trp Leu Arg Ser Ser 
            100                 105                 110         


Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Tyr 
        115                 120                 125             


Trp Ile Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Val Leu Met 
    130                 135                 140                 


Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 
145                 150                 155                 160 


Tyr Asn Thr Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 
                165                 170                 175     


Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 
            180                 185                 190         


Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ile His Leu Leu 
        195                 200                 205             


Ala Gln Arg Leu Leu Leu Arg Arg Glu Phe Ile Pro Ala Pro Gln Gly 
    210                 215                 220                 


Thr Asn Val Leu Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 
225                 230                 235                 240 


Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 
                245                 250                 255     


His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Ser Leu Glu Arg Gln 
            260                 265                 270         


Tyr His Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 
        275                 280                 285             


Asp Gly Glu Val Tyr Pro Pro Ser Val Glu Gln Ala Ser Val Leu Met 
    290                 295                 300                 


Arg Tyr Pro Pro Gly Val Pro Pro Glu Lys Gln Met Ala Val Gly Gln 
305                 310                 315                 320 


Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Phe Ser Thr Ile Trp 
                325                 330                 335     


Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Glu Glu His Pro 
            340                 345                 350         


Thr Trp Asp Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 
        355                 360                 365             


Gly Glu Thr Ile Lys Ile Ile Ile Glu Glu Tyr Val Gln His Leu Ser 
    370                 375                 380                 


Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Arg Ala 
385                 390                 395                 400 


Gln Phe Gln Tyr Arg Asn Arg Ile Ala Leu Glu Phe Asn His Leu Tyr 
                405                 410                 415     


His Trp His Pro Leu Met Pro Asp Ser Phe Gln Val Gly Ser Gln Glu 
            420                 425                 430         


Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr 
        435                 440                 445             


Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Arg Ala Gly Arg 
    450                 455                 460                 


Ile Gly Gly Gly Arg Asn Phe Asp Tyr His Val Leu His Val Ala Glu 
465                 470                 475                 480 


Asp Val Ile Lys Glu Ser Arg Glu Met Arg Leu Gln Ser Phe Asn Glu 
                485                 490                 495     


Tyr Arg Lys Arg Phe Gly Leu Lys Pro Tyr Thr Ser Phe Gln Glu Phe 
            500                 505                 510         


Thr Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp 
        515                 520                 525             


Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Met Leu Glu Lys Cys Gln 
    530                 535                 540                 


Pro Asn Ser Leu Phe Gly Glu Ser Met Ile Glu Met Gly Ala Pro Phe 
545                 550                 555                 560 


Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp 
                565                 570                 575     


Lys Pro Ser Thr Phe Gly Gly Asp Val Gly Phe Asn Ile Val Asn Thr 
            580                 585                 590         


Ala Ser Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr 
        595                 600                 605             


Val Ser Phe Arg Val Pro Asp Tyr Pro Gly Asp Asp Gly Ser Val Phe 
    610                 615                 620                 


Val Arg Pro Ser Thr Glu Leu 
625                 630     


<210>  7
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  7
atccgagaga tgctcatgcg cctggtactc aca                                    33


<210>  8
<211>  33
<212>  DNA
<213>  Mouse

<400>  8
atccgagaag tactcatgcg cctggtactc aca                                    33


<210>  9
<211>  33
<212>  DNA
<213>  Rat

<400>  9
atccgagaag tactcatgcg cctggtactc acg                                    33


<210>  10
<211>  33
<212>  DNA
<213>  Ovine

<400>  10
atccgggaca cgctcatgcg tctggtactc aca                                    33


<210>  11
<211>  33
<212>  DNA
<213>  Bovine

<400>  11
atccgggaca agctcatgcg tctggtactc aca                                    33


<210>  12
<211>  33
<212>  DNA
<213>  Z. Fish

<400>  12
ctcagggatt ggctcatgcg gaaagtgctc aca                                    33


<210>  13
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  13
cttcgaaatg caattatgag ttatgtgttg aca                                    33


<210>  14
<211>  33
<212>  DNA
<213>  Mouse

<400>  14
ctgcgaagtt taatcatgaa atatgtgctg aca                                    33


<210>  15
<211>  33
<212>  DNA
<213>  Rat

<400>  15
cttcggaatt caatcatgag atacgtgttg acg                                    33


<210>  16
<211>  33
<212>  DNA
<213>  Ovine

<400>  16
ctgcgaaata tgattatgag atatgtgttg acg                                    33


<210>  17
<211>  33
<212>  DNA
<213>  Bovine

<400>  17
ctgcgaaata tgattatgag atatgtgttg acg                                    33


<210>  18
<211>  33
<212>  DNA
<213>  Z. Fish

<400>  18
ctgagggatg gcataatgcg ctatatcctg ttg                                    33


<210>  19
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  19
gattgcccca cacccatggg aaccaaaggg aag                                    33


<210>  20
<211>  33
<212>  DNA
<213>  Mouse

<400>  20
gactgcccca cacccatggg gaccaaaggg aag                                    33


<210>  21
<211>  33
<212>  DNA
<213>  Rat

<400>  21
gactgtccca cacccatggg aaccaaaggg aag                                    33


<210>  22
<211>  33
<212>  DNA
<213>  Ovine

<400>  22
gactgtccca cgcccatgga caccaaaggg aag                                    33


<210>  23
<211>  33
<212>  DNA
<213>  Bovine

<400>  23
gactgtccca cgcccatggg caccaaaggg aag                                    33


<210>  24
<211>  33
<212>  DNA
<213>  Z. Fish

<400>  24
gactgtccta caccaatggg aaccaaagga aaa                                    33


<210>  25
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  25
gattgcccga ctcccttggg tgtcaaaggt aaa                                    33


<210>  26
<211>  33
<212>  DNA
<213>  Mouse

<400>  26
gactgcccaa ctcccatggg tgtgaaggga aat                                    33


<210>  27
<211>  33
<212>  DNA
<213>  Rat

<400>  27
gactgcccaa ctcccatggg tgtgaaagga aat                                    33


<210>  28
<211>  33
<212>  DNA
<213>  Ovine

<400>  28
gactgcccaa cacccatggg tgtgaaaggg agg                                    33


<210>  29
<211>  33
<212>  DNA
<213>  Bovine

<400>  29
gactgcccaa cacccatggg tgtgaaaggg agg                                    33


<210>  30
<211>  33
<212>  DNA
<213>  Z. Fish

<400>  30
aactgcccaa cgcctgatct cccaaatgcc aag                                    33


<210>  31
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  31
aaaacttctg gcaagatggg tcctggcttc acc                                    33


<210>  32
<211>  33
<212>  DNA
<213>  Mouse

<400>  32
aagacctctg gaaagatggg tcctggcttt acc                                    33


<210>  33
<211>  33
<212>  DNA
<213>  Rat

<400>  33
aagacctctg gaaagatggg tcctggcttt acc                                    33


<210>  34
<211>  33
<212>  DNA
<213>  Ovine

<400>  34
aaaacttccg gcaagatggg tcctggcttc acc                                    33


<210>  35
<211>  33
<212>  DNA
<213>  Bovine

<400>  35
aaaacttctg gcaagatggg tcctggcttc acc                                    33


<210>  36
<211>  33
<212>  DNA
<213>  Z. Fish

<400>  36
aagactcaca accgtgtggg gctcgggttc aca                                    33


<210>  37
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer

<400>  37
gtcatgagtc gtgagt                                                       16


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer

<400>  38
gtacaactct ccatccagca                                                   20


<210>  39
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer

<400>  39
cagagtcatg agtcgaaga                                                    19


<210>  40
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer

<400>  40
gtacaactct ccatccagca                                                   20


<210>  41
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer

<400>  41
ggtggaagaa tgggagttg                                                    19


<210>  42
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer

<400>  42
ggtggagaat gggagttg                                                     18


<210>  43
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer

<400>  43
ctcgtgcaaa agcgaagtct                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer

<400>  44
tacccaagcc tctcctcaga                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer

<400>  45
aagggcaagg atggtagatg                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer

<400>  46
cctccacacc aaagacaaac                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer

<400>  47
gcagagaaga ccaaggaagg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer

<400>  48
catgccacaa tcacaacgta                                                   20


<210>  49
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  49
agactccttc actcatgacg actc                                              24


<210>  50
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  50
actccttcct gcagagg                                                      17


<210>  51
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  51
tgtgccagat taccctggag a                                                 21


<210>  52
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  52
gggaactggt tttcaactgg agg                                               23


<210>  53
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Flag tag

<400>  53

Asp Asp Asp Asp Lys 
1               5   


<210>  54
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  54
tcagagctct gtggatggtc g                                                 21


<210>  55
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  55
agccaaattc gttg                                                         14


<210>  56
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  56
gtcgccagcc gagc                                                         14


<210>  57
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  57
accttgccca cagcct                                                       16


<210>  58
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  58
ccatgagccg gagtctcttg                                                   20


<210>  59
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  59
ctgatgtagt catgtgctga gttgta                                            26


<210>  60
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  60
catgagccgt gagtgcga                                                     18


<210>  61
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  61
ctgatgtagt catgtgctga gttgta                                            26


<210>  62
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  62
gguggagccu ugaaugcca                                                    19


<210>  63
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  63
ccugguggag ccuugaaug                                                    19


<210>  64
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  64
cucaucucuc uccucugca                                                    19


<210>  65
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  65
ggaauuguau ggagacauu                                                    19


<210>  66
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  66
gaacauggac caccacauc                                                    19


<210>  67
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  67
caagagguuu ggcaugaaa                                                    19


<210>  68
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA

<400>  68
ggagauggca gcagaguug                                                    19


