
                                SEQUENCE LISTING

<110> Genentech, Inc.
      F. Hoffmann-La Roche AG

<120> NSP4 INHIBITORS AND METHODS OF USE
  

<130> 146392022740

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> US 61/890,147       
<151> 2013-10-11  

<150> US 61/893,059       
<151> 2013-10-18  

<150> US 62/053,052       
<151> 2014-09-19  

<160> 115

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
Gly Phe Thr Phe Ser Asn Thr Tyr Ile Ser
 1               5                  10  


<210> 2
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Gly Phe Ile Tyr Pro Ala Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Arg Arg Tyr Arg Leu Ser Phe Asp Tyr
 1               5                  


<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Gly Phe Thr Phe Ser Gly Asn Asp Ile Ser
 1               5                  10  


<210> 5
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Ala Gly Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 6
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Arg Arg Val Ser Phe Tyr Ser Arg His Ala Gly Met Asp Tyr
 1               5                  10                  


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Gly Phe Thr Phe Thr Ser Tyr Ala Ile Ser
 1               5                  10  


<210> 8
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Ala Gly Ile Ser Pro Ser Asn Gly Tyr Thr Asn Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Arg Ala Gly Arg Trp Thr His Ser Asp Ile Asp Tyr
 1               5                  10          


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
 1               5                  10      


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Ser Ala Ser Phe Leu Tyr Ser
 1               5          


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Gln Gln Ser Tyr Thr Thr Pro Pro Thr
 1               5                  


<210> 13
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Tyr Pro Ala Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Arg Tyr Arg Leu Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 14
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Asn
            20                  25                  30          
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Arg Val Ser Phe Tyr Ser Arg His Ala Gly Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 15
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Pro Ser Asn Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Ala Gly Arg Trp Thr His Ser Asp Ile Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 16
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 17
<211> 283
<212> PRT
<213> Homo sapiens

<400> 17
Met Gly Leu Gly Leu Arg Gly Trp Gly Arg Pro Leu Leu Thr Val Ala
 1               5                  10                  15      
Thr Ala Leu Met Leu Pro Val Lys Pro Pro Ala Gly Ser Trp Gly Ala
            20                  25                  30          
Gln Ile Ile Gly Gly His Glu Val Thr Pro His Ser Arg Pro Tyr Met
        35                  40                  45              
Ala Ser Val Arg Phe Gly Gly Gln His His Cys Gly Gly Phe Leu Leu
    50                  55                  60                  
Arg Ala Arg Trp Val Val Ser Ala Ala His Cys Phe Ser His Arg Asp
65                  70                  75                  80  
Leu Arg Thr Gly Leu Val Val Leu Gly Ala His Val Leu Ser Thr Ala
                85                  90                  95      
Glu Pro Thr Gln Gln Val Phe Gly Ile Asp Ala Leu Thr Thr His Pro
            100                 105                 110         
Asp Tyr His Pro Met Thr His Ala Asn Asp Ile Cys Leu Leu Arg Leu
        115                 120                 125             
Asn Gly Ser Ala Val Leu Gly Pro Ala Val Gly Leu Leu Arg Leu Pro
    130                 135                 140                 
Gly Arg Arg Ala Arg Pro Pro Thr Ala Gly Thr Arg Cys Arg Val Ala
145                 150                 155                 160 
Gly Trp Gly Phe Val Ser Asp Phe Glu Glu Leu Pro Pro Gly Leu Met
                165                 170                 175     
Glu Ala Lys Val Arg Val Leu Asp Pro Asp Val Cys Asn Ser Ser Trp
            180                 185                 190         
Lys Gly His Leu Thr Leu Thr Met Leu Cys Thr Arg Ser Gly Asp Ser
        195                 200                 205             
His Arg Arg Gly Phe Cys Ser Ala Asp Ser Gly Gly Pro Leu Val Cys
    210                 215                 220                 
Arg Asn Arg Ala His Gly Leu Val Ser Phe Ser Gly Leu Trp Cys Gly
225                 230                 235                 240 
Asp Pro Lys Thr Pro Asp Val Tyr Thr Gln Val Ser Ala Phe Val Ala
                245                 250                 255     
Trp Ile Trp Asp Val Val Arg Arg Ser Ser Pro Gln Pro Gly Pro Leu
            260                 265                 270         
Pro Gly Thr Thr Arg Pro Pro Gly Glu Ala Ala
        275                 280             


<210> 18
<211> 283
<212> PRT
<213> Homo sapiens

<400> 18
Met Gly Leu Gly Leu Arg Gly Trp Gly Arg Pro Leu Leu Thr Val Ala
 1               5                  10                  15      
Thr Ala Leu Met Leu Pro Val Lys Pro Pro Ala Gly Ser Trp Gly Ala
            20                  25                  30          
Gln Ile Ile Gly Gly His Glu Val Thr Pro His Ser Arg Pro Tyr Met
        35                  40                  45              
Ala Ser Val Arg Phe Gly Gly Gln His His Cys Gly Gly Phe Leu Leu
    50                  55                  60                  
Arg Ala Arg Trp Val Val Ser Ala Ala His Cys Phe Ser His Arg Asp
65                  70                  75                  80  
Leu Arg Thr Gly Leu Val Val Leu Gly Ala His Val Leu Ser Thr Ala
                85                  90                  95      
Glu Pro Thr Gln Gln Val Phe Gly Ile Asp Ala Leu Thr Thr His Pro
            100                 105                 110         
Asp Tyr His Pro Met Thr His Ala Asn Asp Ile Cys Leu Leu Arg Leu
        115                 120                 125             
Asn Gly Ser Ala Val Leu Gly Pro Ala Val Gly Leu Leu Arg Pro Pro
    130                 135                 140                 
Gly Arg Arg Ala Arg Pro Pro Thr Ala Gly Thr Arg Cys Arg Val Ala
145                 150                 155                 160 
Gly Trp Gly Phe Val Ser Asp Phe Glu Glu Leu Pro Pro Gly Leu Met
                165                 170                 175     
Glu Ala Lys Val Arg Val Leu Asp Pro Asp Val Cys Asn Ser Ser Trp
            180                 185                 190         
Lys Gly His Leu Thr Leu Thr Met Leu Cys Thr Arg Ser Gly Asp Ser
        195                 200                 205             
His Arg Arg Gly Phe Cys Ser Ala Asp Ser Gly Gly Pro Leu Val Cys
    210                 215                 220                 
Arg Asn Arg Ala His Gly Leu Val Ser Phe Ser Gly Leu Trp Cys Gly
225                 230                 235                 240 
Asp Pro Lys Thr Pro Asp Val Tyr Thr Gln Val Ser Ala Phe Val Ala
                245                 250                 255     
Trp Ile Trp Asp Val Val Arg Arg Ser Ser Pro Gln Pro Gly Pro Leu
            260                 265                 270         
Pro Gly Thr Thr Arg Pro Pro Gly Glu Ala Ala
        275                 280             


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Arg Ala Ser Gln Asp Val Ser
 1               5          


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Gly Phe Thr Phe Ser Gly Ser Trp Ile Ser
 1               5                  10  


<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Gly Thr Ile Ser Pro Tyr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 22
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Arg Val Leu Arg Pro Lys Val Tyr Ala Ser Val Met Asp Tyr
 1               5                  10                  


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Gly Phe Thr Phe Ser Gly Tyr Ser Ile His
 1               5                  10  


<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Ala Gly Ile Ser Pro Thr Asn Gly Tyr Thr Asp Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Arg Leu Val Phe Tyr Arg Gly Val Met Asp Tyr
 1               5                  10      


<210> 26
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Gly Phe Thr Phe Ser Asp Asn Trp Ile Ser
 1               5                  10  


<210> 27
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Gly Tyr Ile Tyr Pro Ala Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 28
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Ser Asp Ser Pro His Ala Tyr Trp Tyr Ala Met Asp Tyr
 1               5                  10              


<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Gly Phe Thr Phe Thr Asn Asn Ser Ile Ser
 1               5                  10  


<210> 30
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Gly Ala Ile Ser Pro Asn Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 31
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Arg Asn Ala Trp His Tyr Ser Trp Val Gly Val Met Asp Tyr
 1               5                  10                  


<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Gly Phe Thr Phe Thr Asp Tyr Ser Ile His
 1               5                  10  


<210> 33
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Ala Glu Ile Tyr Pro Tyr Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Arg Asp Gly Asp Gly Trp Phe Asp Trp Ala Met Asp Tyr
 1               5                  10              


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Gly Phe Thr Phe Ser Ser Thr Ala Ile Ser
 1               5                  10  


<210> 36
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
Gly Glu Ile Tyr Pro Ser Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Arg Val Lys Trp Ala Val Ser Ser Leu Gly Val Met Asp Tyr
 1               5                  10                  


<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Gly Phe Thr Phe Thr Asp Ser Asp Ile Ser
 1               5                  10  


<210> 39
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Ala Trp Ile Ser Pro Ser Asp Gly Ala Thr Asp Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 40
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
His Glu Ala Ser Asp Asp Asp Tyr Ala Ile Asp Tyr
 1               5                  10          


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Gly Phe Thr Phe Ser Asp Tyr Trp Ile Ser
 1               5                  10  


<210> 42
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Ala Gly Ile Ser Pro Asn Asn Gly Asp Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Arg Glu Asp Asp Asp Glu Arg Asp Tyr Ala Met Asp Tyr
 1               5                  10              


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Gly Phe Thr Phe Thr Gly Tyr Gly Ile Ser
 1               5                  10  


<210> 45
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Gly Trp Ile Tyr Pro Ala Ser Gly Ala Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 46
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
Arg His Arg Ala Phe Asp Trp Tyr Pro Tyr Tyr Ile Gly Ser Ser Val
 1               5                  10                  15      
Met Asp Tyr
            


<210> 47
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
Gly Phe Thr Phe Ser Asp Tyr Ser Ile Ser
 1               5                  10  


<210> 48
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
Gly Glu Ile Asn Pro Ala Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 49
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
Arg Gly Asp Phe Pro Phe Trp Ser Asp Ala Tyr Tyr Val Met Asp Tyr
 1               5                  10                  15      


<210> 50
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
Gly Phe Thr Phe Ser Asp Asn Asp Ile Ser
 1               5                  10  


<210> 51
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
Gly Ser Ile Ser Pro Asp Asn Gly Asp Thr Asn Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 52
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
Arg Asp Asp Val Pro Ala Val Phe Thr Ser Ala Met Asp Tyr
 1               5                  10                  


<210> 53
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
Gly Phe Thr Phe Ser Gly Ser Asp Ile Ser
 1               5                  10  


<210> 54
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
Gly Glu Ile Tyr Pro Ser Asn Gly Asp Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 55
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
Arg Ser Val Arg Pro Ser Trp Trp Ala Met Asp Tyr
 1               5                  10          


<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 56
Gly Phe Thr Phe Ser Ser Tyr Asp Ile Ser
 1               5                  10  


<210> 57
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 57
Gly Thr Ile Ser Pro Tyr Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 58
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 58
Arg Tyr Ile Arg Arg Tyr Ser Val His Tyr Gly Met Asp Tyr
 1               5                  10                  


<210> 59
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
Gly Phe Thr Phe Thr Ser Thr Ser Ile His
 1               5                  10  


<210> 60
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 60
Ala Glu Ile Thr Pro His Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 61
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 61
Arg Gly Arg Thr Lys Trp Gly Trp Leu Tyr Gly Met Asp Tyr
 1               5                  10                  


<210> 62
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
Gly Phe Thr Phe Thr Asn Asn Ser Ile His
 1               5                  10  


<210> 63
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 63
Ala Glu Ile Ala Pro Asp Asp Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 64
Arg Gly Val Ile Arg Tyr Ala Tyr Leu Tyr Ala Met Asp Tyr
 1               5                  10                  


<210> 65
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 65
Gly Phe Thr Phe Ser Gly Ser Gly Ile His
 1               5                  10  


<210> 66
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 66
Ala Trp Ile Ser Pro Thr Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 67
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 67
Lys Ser Leu Phe His Asn Val Ala Phe Asp Tyr
 1               5                  10      


<210> 68
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 68
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Thr Ile Ser Pro Tyr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Leu Arg Pro Lys Val Tyr Ala Ser Val Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 69
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 69
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
            20                  25                  30          
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Pro Thr Asn Gly Tyr Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Leu Val Phe Tyr Arg Gly Val Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 70
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 70
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Tyr Ile Tyr Pro Ala Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ser Asp Ser Pro His Ala Tyr Trp Tyr Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 71
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Asn
            20                  25                  30          
Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Ala Ile Ser Pro Asn Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asn Ala Trp His Tyr Ser Trp Val Gly Val Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 72
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 72
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr
            20                  25                  30          
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Tyr Pro Tyr Ser Gly Asp Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Gly Asp Gly Trp Phe Asp Trp Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 73
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 73
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Thr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Glu Ile Tyr Pro Ser Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Lys Trp Ala Val Ser Ser Leu Gly Val Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 74
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 74
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Ser
            20                  25                  30          
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Ser Asp Gly Ala Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala His Glu Ala Ser Asp Asp Asp Tyr Ala Ile Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 75
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 75
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Pro Asn Asn Gly Asp Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Asp Asp Asp Glu Arg Asp Tyr Ala Met Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 76
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 76
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Tyr Pro Ala Ser Gly Ala Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Arg Ala Phe Asp Trp Tyr Pro Tyr Tyr Ile Gly Ser Ser
            100                 105                 110         
Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125         


<210> 77
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 77
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Glu Ile Asn Pro Ala Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Asp Phe Pro Phe Trp Ser Asp Ala Tyr Tyr Val Met Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 78
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 78
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asn
            20                  25                  30          
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Ser Ile Ser Pro Asp Asn Gly Asp Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Asp Val Pro Ala Val Phe Thr Ser Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 79
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30          
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Glu Ile Tyr Pro Ser Asn Gly Asp Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Val Arg Pro Ser Trp Trp Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 80
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Thr Ile Ser Pro Tyr Asp Gly Tyr Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Ile Arg Arg Tyr Ser Val His Tyr Gly Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 81
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 81
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Thr
            20                  25                  30          
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Thr Pro His Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Arg Thr Lys Trp Gly Trp Leu Tyr Gly Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 82
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 82
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Asn
            20                  25                  30          
Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Glu Ile Ala Pro Asp Asp Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Val Ile Arg Tyr Ala Tyr Leu Tyr Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 83
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 83
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30          
Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Thr Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Ser Leu Phe His Asn Val Ala Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 84
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 84
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Thr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Tyr Pro Ala Asn Gly Ala Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Tyr Arg Leu Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 85
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 85
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Asn
            20                  25                  30          
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Val Ser Phe Tyr Ser Arg His Ala Gly Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 86
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 86
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Gly Ile Ser Pro Ser Asn Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ala Gly Arg Trp Thr His Ser Asp Ile Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 87
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 87
Lys Arg His Leu His Asn Val Ala Phe Asp Tyr
 1               5                  10      


<210> 88
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 88
Ala Trp Ile Pro Thr Ala Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly
        


<210> 89
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 89
Arg Gly Leu Phe His Asn Val Ala Phe Asp Tyr
 1               5                  10      


<210> 90
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 90
Arg Val Phe Phe His Asn Val Ala Phe Asp Tyr
 1               5                  10      


<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = K or R

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = S, G, or V

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = L or F

<400> 91
Xaa Xaa Xaa Phe His Asn Val Ala Phe Asp Tyr
 1               5                  10      


<210> 92
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 92
Gln Gln Ser Tyr Gly Phe Pro Leu Thr
 1               5                  


<210> 93
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 93
Gln Gln Ser Tyr Asp Phe Pro Leu Thr
 1               5                  


<210> 94
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 94
Gln Gln Ser Ala Gly Phe Pro Leu Thr
 1               5                  


<210> 95
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Y or A

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = T, G, or D

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = T or F

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = P or L

<400> 95
Gln Gln Ser Xaa Xaa Xaa Pro Xaa Thr
 1               5                  


<210> 96
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 96
Gln Gln Ala Tyr Ser Ala Pro Pro Thr
 1               5                  


<210> 97
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 97
Gln Gln Ser Tyr Thr Ala Pro Pro Thr
 1               5                  


<210> 98
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 98
Gln Gln Ala Asn Ser Thr Pro Pro Thr
 1               5                  


<210> 99
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 99
Gln Gln Asn Phe Ser Ser Pro Pro Thr
 1               5                  


<210> 100
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 100
Gln Gln Thr Tyr Asn Ala Pro Pro Thr
 1               5                  


<210> 101
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = S, A, N, or T

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Y, N, or F

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = T, S, or N

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = T, A, or S

<400> 101
Gln Gln Xaa Xaa Xaa Xaa Pro Pro Thr
 1               5                  


<210> 102
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 102
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Phe Pro Leu
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 103
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 103
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Phe Pro Leu
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 104
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 104
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ala Gly Phe Pro Leu
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 105
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 105
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30          
Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Thr Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Arg His Leu His Asn Val Ala Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 106
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 106
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Ala Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 107
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 107
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30          
Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Pro Thr Ala Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Ser Leu Phe His Asn Val Ala Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 108
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 108
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ala Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 109
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 109
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 110
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 110
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30          
Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Thr Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Phe His Asn Val Ala Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 111
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 111
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30          
Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Thr Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Phe Phe His Asn Val Ala Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 112
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 112
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Phe Ser Ser Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 113
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 113
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Asn Ala Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 114
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 114
Ala Ser Thr Lys Gly Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly
 1               5                  10                  15      
Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu
    50                  55                  60                  
Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys
                85                  90                  95      
Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys
            100                 105                 110         
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro
        115                 120                 125             
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys
    130                 135                 140                 
Val Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp
145                 150                 155                 160 
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg
                165                 170                 175     
Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln
            180                 185                 190         
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn
        195                 200                 205             
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly
    210                 215                 220                 
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu
225                 230                 235                 240 
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met
                245                 250                 255     
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu
            260                 265                 270         
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe
        275                 280                 285             
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn
    290                 295                 300                 
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr
305                 310                 315                 320 
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
                325                 330 


<210> 115
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 115
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln
 1               5                  10                  15      
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln
        35                  40                  45              
Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg
65                  70                  75                  80  
His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro
                85                  90                  95      
Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
            100                 105     


