                         SEQUENCE LISTING

<110>  The United States of America as Represented by the 
       Secretary, Department of Health and Human Services
       BioMed Valley Discoveries, Inc.
       Dimitrov, Dimiter
       Zhu, Zhongyu
       St. Croix, Brad
       Zudaire, Enrique
       Saha, Saurabh
       Zhang, Xiaoyan
       DeCrescenzo, Gary
       Welsch, Dean
       
 
<120>  TEM8 ANTIBODIES AND THEIR USE

<130>  4239-91524-02

<150>  61/889,958
<151>  2013-10-11

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Pro Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Gly Glu Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Tyr Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  2

Ser Ser Glu Leu Thr Gln Asp Pro Val Val Ser Val Ala Leu Gly Glu 
1               5                   10                  15      


Thr Val Ser Ile Thr Cys Gln Gly Asp Asn Leu Arg Asp Phe Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Met Tyr 
        35                  40                  45              


Gly Lys Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Leu Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Asn Ser Lys His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Tyr Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  4

Ser Ser Glu Leu Thr Gln Asp Pro Val Val Ser Val Ala Leu Gly Glu 
1               5                   10                  15      


Thr Val Ser Ile Thr Cys Gln Gly Asp Asn Leu Arg Asp Phe Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Met Tyr 
        35                  40                  45              


Gly Lys Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Leu Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Asn Ser Lys His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Ser Ser Trp Tyr Arg Gly Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Seuqence

<220>
<223>  antibody sequence

<400>  7

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Thr Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Pro Gly Ser Pro Lys Trp Leu Ala Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Ala Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  1695
<212>  DNA
<213>  Homo sapiens

<400>  9
atggccacgg cggagcggag agccctcggc atcggcttcc agtggctctc tttggccact       60

ctggtgctca tctgcgccgg gcaaggggga cgcagggagg atgggggtcc agcctgctac      120

ggcggatttg acctgtactt cattttggac aaatcaggaa gtgtgctgca ccactggaat      180

gaaatctatt actttgtgga acagttggct cacaaattca tcagcccaca gttgagaatg      240

tcctttattg ttttctccac ccgaggaaca accttaatga aactgacaga agacagagaa      300

caaatccgtc aaggcctaga agaactccag aaagttctgc caggaggaga cacttacatg      360

catgaaggat ttgaaagggc cagtgagcag atttattatg aaaacagaca agggtacagg      420

acagccagcg tcatcattgc tttgactgat ggagaactcc atgaagatct ctttttctat      480

tcagagaggg aggctaatag gtctcgagat cttggtgcaa ttgtttactg tgttggtgtg      540

aaagatttca atgagacaca gctggcccgg attgcggaca gtaaggatca tgtgtttccc      600

gtgaatgacg gctttcaggc tctgcaaggc atcatccact caattttgaa gaagtcctgc      660

atcgaaattc tagcagctga accatccacc atatgtgcag gagagtcatt tcaagttgtc      720

gtgagaggaa acggcttccg acatgcccgc aacgtggaca gggtcctctg cagcttcaag      780

atcaatgact cggtcacact caatgagaag cccttttctg tggaagatac ttatttactg      840

tgtccagcgc ctatcttaaa agaagttggc atgaaagctg cactccaggt cagcatgaac      900

gatggcctct cttttatctc cagttctgtc atcatcacca ccacacactg ttctgacggt      960

tccatcctgg ccatcgccct gctgatcctg ttcctgctcc tagccctggc tctcctctgg     1020

tggttctggc ccctctgctg cactgtgatt atcaaggagg tccctccacc ccctgccgag     1080

gagagtgagg aagaagatga tgatggtctg cctaagaaaa agtggccaac ggtagacgcc     1140

tcttattatg gtgggagagg cgttggaggc attaaaagaa tggaggttcg ttggggagaa     1200

aagggctcca cagaagaagg tgctaagttg gaaaaggcaa agaatgcaag agtcaagatg     1260

ccggagcagg aatatgaatt ccctgagccg cgaaatctca acaacaatat gcgtcggcct     1320

tcttcccccc ggaagtggta ctctccaatc aagggaaaac tcgatgcctt gtgggtccta     1380

ctgaggaaag gatatgatcg tgtgtctgtg atgcgtccac agccaggaga cacggggcgc     1440

tgcatcaact tcaccagggt caagaacaac cagccagcca agtacccact caacaacgcc     1500

taccacacct cctcgccgcc tcctgccccc atctacactc ccccacctcc tgcgccccac     1560

tgccctcccc cgccccccag cgcccctacc cctcccatcc cgtccccacc ttccaccctt     1620

ccccctcctc cccaggctcc acctcccaac agggcacctc ctccctcccg ccctcctcca     1680

aggccttctg tctag                                                      1695


<210>  10
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Thr Ala Glu Arg Arg Ala Leu Gly Ile Gly Phe Gln Trp Leu 
1               5                   10                  15      


Ser Leu Ala Thr Leu Val Leu Ile Cys Ala Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Asp Gly Gly Pro Ala Cys Tyr Gly Gly Phe Asp Leu Tyr Phe Ile 
        35                  40                  45              


Leu Asp Lys Ser Gly Ser Val Leu His His Trp Asn Glu Ile Tyr Tyr 
    50                  55                  60                  


Phe Val Glu Gln Leu Ala His Lys Phe Ile Ser Pro Gln Leu Arg Met 
65                  70                  75                  80  


Ser Phe Ile Val Phe Ser Thr Arg Gly Thr Thr Leu Met Lys Leu Thr 
                85                  90                  95      


Glu Asp Arg Glu Gln Ile Arg Gln Gly Leu Glu Glu Leu Gln Lys Val 
            100                 105                 110         


Leu Pro Gly Gly Asp Thr Tyr Met His Glu Gly Phe Glu Arg Ala Ser 
        115                 120                 125             


Glu Gln Ile Tyr Tyr Glu Asn Arg Gln Gly Tyr Arg Thr Ala Ser Val 
    130                 135                 140                 


Ile Ile Ala Leu Thr Asp Gly Glu Leu His Glu Asp Leu Phe Phe Tyr 
145                 150                 155                 160 


Ser Glu Arg Glu Ala Asn Arg Ser Arg Asp Leu Gly Ala Ile Val Tyr 
                165                 170                 175     


Cys Val Gly Val Lys Asp Phe Asn Glu Thr Gln Leu Ala Arg Ile Ala 
            180                 185                 190         


Asp Ser Lys Asp His Val Phe Pro Val Asn Asp Gly Phe Gln Ala Leu 
        195                 200                 205             


Gln Gly Ile Ile His Ser Ile Leu Lys Lys Ser Cys Ile Glu Ile Leu 
    210                 215                 220                 


Ala Ala Glu Pro Ser Thr Ile Cys Ala Gly Glu Ser Phe Gln Val Val 
225                 230                 235                 240 


Val Arg Gly Asn Gly Phe Arg His Ala Arg Asn Val Asp Arg Val Leu 
                245                 250                 255     


Cys Ser Phe Lys Ile Asn Asp Ser Val Thr Leu Asn Glu Lys Pro Phe 
            260                 265                 270         


Ser Val Glu Asp Thr Tyr Leu Leu Cys Pro Ala Pro Ile Leu Lys Glu 
        275                 280                 285             


Val Gly Met Lys Ala Ala Leu Gln Val Ser Met Asn Asp Gly Leu Ser 
    290                 295                 300                 


Phe Ile Ser Ser Ser Val Ile Ile Thr Thr Thr His Cys Ser Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ala Ile Ala Leu Leu Ile Leu Phe Leu Leu Leu Ala Leu 
                325                 330                 335     


Ala Leu Leu Trp Trp Phe Trp Pro Leu Cys Cys Thr Val Ile Ile Lys 
            340                 345                 350         


Glu Val Pro Pro Pro Pro Ala Glu Glu Ser Glu Glu Glu Asp Asp Asp 
        355                 360                 365             


Gly Leu Pro Lys Lys Lys Trp Pro Thr Val Asp Ala Ser Tyr Tyr Gly 
    370                 375                 380                 


Gly Arg Gly Val Gly Gly Ile Lys Arg Met Glu Val Arg Trp Gly Glu 
385                 390                 395                 400 


Lys Gly Ser Thr Glu Glu Gly Ala Lys Leu Glu Lys Ala Lys Asn Ala 
                405                 410                 415     


Arg Val Lys Met Pro Glu Gln Glu Tyr Glu Phe Pro Glu Pro Arg Asn 
            420                 425                 430         


Leu Asn Asn Asn Met Arg Arg Pro Ser Ser Pro Arg Lys Trp Tyr Ser 
        435                 440                 445             


Pro Ile Lys Gly Lys Leu Asp Ala Leu Trp Val Leu Leu Arg Lys Gly 
    450                 455                 460                 


Tyr Asp Arg Val Ser Val Met Arg Pro Gln Pro Gly Asp Thr Gly Arg 
465                 470                 475                 480 


Cys Ile Asn Phe Thr Arg Val Lys Asn Asn Gln Pro Ala Lys Tyr Pro 
                485                 490                 495     


Leu Asn Asn Ala Tyr His Thr Ser Ser Pro Pro Pro Ala Pro Ile Tyr 
            500                 505                 510         


Thr Pro Pro Pro Pro Ala Pro His Cys Pro Pro Pro Pro Pro Ser Ala 
        515                 520                 525             


Pro Thr Pro Pro Ile Pro Ser Pro Pro Ser Thr Leu Pro Pro Pro Pro 
    530                 535                 540                 


Gln Ala Pro Pro Pro Asn Arg Ala Pro Pro Pro Ser Arg Pro Pro Pro 
545                 550                 555                 560 


Arg Pro Ser Val 
                


<210>  11
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  11
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggacctc agtgaaggtc       60

tcctgcaagg ttcctggata caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaactac      180

gcacagaagt tccagggcag agtcacgatt accggggagg aatccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatacg      300

gactacatgt ttgactactg gggccaggga accctggtca ccgtgagctc a               351


<210>  12
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  12
tcttctgagc tgactcagga ccctgttgtg tctgtggcct tgggagagac agtcagtatc       60

acatgccaag gagacaacct cagagacttt tatgcaagct ggtaccaaca gaagccagga      120

caggcccctc tactagtcat gtatggtaaa aacaggcggc cctcagggat cccagaccga      180

ttctctggct ccacctcagg aaacacactt tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg tagctcccgg gacaacagta agcatgtggt gttcggcggg      300

gggaccaagg tcaccgtcct a                                                321


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  13
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttctggata caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatacg      300

gactacatgt ttgactactg gggccaggga accctggtca ccgtgagctc a               351


<210>  14
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  antibody sequence

<400>  14
tcttctgagc tgactcagga ccctgttgtg tctgtggcct tgggagagac agtcagtatc       60

acatgccaag gagacaacct cagagacttt tatgcaagct ggtaccaaca gaagccagga      120

caggcccctc tactagtcat gtatggtaaa aacaggcggc cctcagggat cccagaccga      180

ttctctggct ccacctcagg aaacacactt tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg tagctcccgg gacaacagta agcatgtggt gttcggcggg      300

gggaccaagg tcaccgtcct a                                                321


<210>  15
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  15
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cgtgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatt atctcaaatg atggaagcaa taagtactac      180

gcagaccccg tgaggggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgt acgtggcagc      300

agctggtatc gcggaaattg gttcgacccc tggggccagg gaaccctggt caccgtgagc      360

tca                                                                    363


<210>  16
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  16
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcgcttgcc gggcaagtca gaccattagt aggtatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtctcatca      180

aggttcagtg gcagtggatc tgggacagag ttcactctca ccatcagcag tctgcagcct      240

gaagattttg caacttattt ctgtcaacag acttacagtc ccccgatcac cttcggccaa      300

gggacacgac tggagattaa acga                                             324


<210>  17
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  17
gaggtgcagc tggtggagac cggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta ccagtggtag cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcgggctgag atctgacgac actgccgtgt attactgtgt gagagatccg      300

ggttctccta agtggctggc cttcgacccc tggggccagg gcaccctggt caccgtgagc      360

tca                                                                    363


<210>  18
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  18
gacatccagt tgacccagtc tccatcctcc ttgtctgctt ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtcg ggccattagt aggtatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtctcatca      180

aggttcagtg gcagtggatc tgggacagag ttcactctca ccatcagcag tctgcagcct      240

gaagattttg caacttattt ctgtcaacag acttacagtc ccccgatcac cttcggccaa      300

gggacacgac tggagattaa acgt                                             324


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  22
<212>  PRT
<213>  homo sapiens

<400>  20

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr 
            20          


<210>  21
<211>  236
<212>  PRT
<213>  homo sapiens

<400>  21

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235     


<210>  22
<211>  69
<212>  PRT
<213>  homo sapiens

<400>  22

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  23
<211>  67
<212>  PRT
<213>  homo sapiens

<400>  23

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg 
65          


<210>  24
<211>  112
<212>  PRT
<213>  homo sapiens

<400>  24

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  25
<211>  84
<212>  PRT
<213>  homo sapiens

<400>  25

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  26
<211>  40
<212>  PRT
<213>  homo sapiens

<400>  26

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  27
<211>  42
<212>  PRT
<213>  homo sapiens

<400>  27

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  28
<211>  47
<212>  PRT
<213>  homo sapiens

<400>  28

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


