                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSITE PAUL SABATIER TOULOUSE III
       UNIVERSITE DE NICE SOFIA ANTIPOLIS
 
<120>  RNY-derived small RNAs as biomarkers for atherosclerosis-related 
       disorders

<130>  BET 14P2177

<150>  EP13306439.4
<151>  2013-10-18

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  1
ggctggtccg aaggtagtga gttatctcaa ttgattgttc acagtcagtt acagatcgaa       60

ctccttgttc tactctttcc ccccttctca ctactgcact tgactagtct ttt             113


<210>  2
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  2
ggctggtccg agtgcagtgg tgtttacaac taattgatca caaccagtta cagatttctt       60

tgttccttct ccactcccac tgcttcactt gactagcctt tt                         102


<210>  3
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  3
ggctggtccg atggtagtgg gttatcagaa cttattaaca ttagtgtcac taaagttggt       60

atacaacccc ccactgctaa atttgactgg cttttt                                 96


<210>  4
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  4
agttggtccg agtgttgtgg gttattgtta agttgattta acattgtctc cccccacaac       60

cgcgcttgac tagcttgctg tttt                                              84


<210>  5
<211>  111
<212>  DNA
<213>  Mus musculus

<400>  5
ggctggtccg aaggtagtga gttatctcaa ttgattgttc acagtcagtt acagattgaa       60

ctcctgttct acactttccc cccttctcac tactgcactt gactagtctt t               111


<210>  6
<211>  101
<212>  DNA
<213>  Mus musculus

<400>  6
ggttggtccg agagtagtgg tgtttacaac taattgatca caaccagtta cagatttctt       60

tgttccttct ccgctcccac tgcttcactt gaccagcctt t                          101


<210>  7
<211>  31
<212>  RNA
<213>  Homo sapiens

<400>  7
ggcugguccg aagguaguga guuaucucaa u                                      31


<210>  8
<211>  28
<212>  RNA
<213>  Homo sapiens

<400>  8
cuucucacua cugcacuuga cuagucuu                                          28


<210>  9
<211>  31
<212>  RNA
<213>  Homo sapiens

<400>  9
ggcugguccg agugcagugg uguuuacaac u                                      31


<210>  10
<211>  28
<212>  RNA
<213>  Homo sapiens

<400>  10
acucccacug cuucacuuga cuagccuu                                          28


<210>  11
<211>  31
<212>  RNA
<213>  Homo sapiens

<400>  11
ggcgguccga ugguaguggg uuaucagaac u                                      31


<210>  12
<211>  28
<212>  RNA
<213>  Homo sapiens

<400>  12
accccccacu gcuaaauuug acuggcuu                                          28


<210>  13
<211>  26
<212>  RNA
<213>  Homo sapiens

<400>  13
cccccacaac cgcgcuugac uagcuu                                            26


<210>  14
<211>  31
<212>  RNA
<213>  Mus musculus

<400>  14
ggcugguccg aagguaguga guuaucucaa u                                      31


<210>  15
<211>  28
<212>  RNA
<213>  Mus musculus

<400>  15
cuucucacua cugcacuuga cuagucuu                                          28


<210>  16
<211>  24
<212>  RNA
<213>  Mus musculus

<400>  16
gguugguccg agaguagugg uguu                                              24


<210>  17
<211>  28
<212>  RNA
<213>  Mus musculus

<400>  17
cuucucacua cugcacuuga cuagucuu                                          28


<210>  18
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Tyr Ser Gly Ala Gly Pro Ala Leu Ala Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      


Pro Ile Gln Gly Tyr Ala Phe Lys Pro Pro Pro Arg Pro Asp Phe Gly 
            20                  25                  30          


Thr Ser Gly Arg Thr Ile Lys Leu Gln Ala Asn Phe Phe Glu Met Asp 
        35                  40                  45              


Ile Pro Lys Ile Asp Ile Tyr His Tyr Glu Leu Asp Ile Lys Pro Glu 
    50                  55                  60                  


Lys Cys Pro Arg Arg Val Asn Arg Glu Ile Val Glu His Met Val Gln 
65                  70                  75                  80  


His Phe Lys Thr Gln Ile Phe Gly Asp Arg Lys Pro Val Phe Asp Gly 
                85                  90                  95      


Arg Lys Asn Leu Tyr Thr Ala Met Pro Leu Pro Ile Gly Arg Asp Lys 
            100                 105                 110         


Val Glu Leu Glu Val Thr Leu Pro Gly Glu Gly Lys Asp Arg Ile Phe 
        115                 120                 125             


Lys Val Ser Ile Lys Trp Val Ser Cys Val Ser Leu Gln Ala Leu His 
    130                 135                 140                 


Asp Ala Leu Ser Gly Arg Leu Pro Ser Val Pro Phe Glu Thr Ile Gln 
145                 150                 155                 160 


Ala Leu Asp Val Val Met Arg His Leu Pro Ser Met Arg Tyr Thr Pro 
                165                 170                 175     


Val Gly Arg Ser Phe Phe Thr Ala Ser Glu Gly Cys Ser Asn Pro Leu 
            180                 185                 190         


Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro 
        195                 200                 205             


Ser Leu Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe 
    210                 215                 220                 


Tyr Lys Ala Gln Pro Val Ile Glu Phe Val Cys Glu Val Leu Asp Phe 
225                 230                 235                 240 


Lys Ser Ile Glu Glu Gln Gln Lys Pro Leu Thr Asp Ser Gln Arg Val 
                245                 250                 255     


Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Ile Thr His Cys 
            260                 265                 270         


Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro 
        275                 280                 285             


Ala Ser His Gln Thr Phe Pro Leu Gln Gln Glu Ser Gly Gln Thr Val 
    290                 295                 300                 


Glu Cys Thr Val Ala Gln Tyr Phe Lys Asp Arg His Lys Leu Val Leu 
305                 310                 315                 320 


Arg Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His 
                325                 330                 335     


Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys 
            340                 345                 350         


Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Arg Ala Thr 
        355                 360                 365             


Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Lys Leu Met Arg 
    370                 375                 380                 


Ser Ala Ser Phe Asn Thr Asp Pro Tyr Val Arg Glu Phe Gly Ile Met 
385                 390                 395                 400 


Val Lys Asp Glu Met Thr Asp Val Thr Gly Arg Val Leu Gln Pro Pro 
                405                 410                 415     


Ser Ile Leu Tyr Gly Gly Arg Asn Lys Ala Ile Ala Thr Pro Val Gln 
            420                 425                 430         


Gly Val Trp Asp Met Arg Asn Lys Gln Phe His Thr Gly Ile Glu Ile 
        435                 440                 445             


Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Arg Gln Cys Thr Glu 
    450                 455                 460                 


Val His Leu Lys Ser Phe Thr Glu Gln Leu Arg Lys Ile Ser Arg Asp 
465                 470                 475                 480 


Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln 
                485                 490                 495     


Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr 
            500                 505                 510         


Ala Gly Leu Gln Leu Val Val Val Ile Leu Pro Gly Lys Thr Pro Val 
        515                 520                 525             


Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Val Leu Gly Met Ala Thr 
    530                 535                 540                 


Gln Cys Val Gln Met Lys Asn Val Gln Arg Thr Thr Pro Gln Thr Leu 
545                 550                 555                 560 


Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Val Asn Asn 
                565                 570                 575     


Ile Leu Leu Pro Gln Gly Arg Pro Pro Val Phe Gln Gln Pro Val Ile 
            580                 585                 590         


Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys 
        595                 600                 605             


Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Asn Arg 
    610                 615                 620                 


Tyr Cys Ala Thr Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln 
625                 630                 635                 640 


Asp Leu Ala Ala Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser 
                645                 650                 655     


Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Ser 
            660                 665                 670         


Glu Gly Gln Phe Gln Gln Val Leu His His Glu Leu Leu Ala Ile Arg 
        675                 680                 685             


Glu Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Phe 
    690                 695                 700                 


Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Thr Asp Lys 
705                 710                 715                 720 


Asn Glu Arg Val Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val 
                725                 730                 735     


Asp Thr Lys Ile Thr His Pro Thr Glu Phe Asp Phe Tyr Leu Cys Ser 
            740                 745                 750         


His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val Leu 
        755                 760                 765             


Trp Asp Asp Asn Arg Phe Ser Ser Asp Glu Leu Gln Ile Leu Thr Tyr 
    770                 775                 780                 


Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro 
785                 790                 795                 800 


Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His 
                805                 810                 815     


Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Thr Ser Gly 
            820                 825                 830         


Gln Ser Asn Gly Arg Asp His Gln Ala Leu Ala Lys Ala Val Gln Val 
        835                 840                 845             


His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855                 


<210>  19
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210>  20
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile 
1               5                   10                  15      


Ala Asn Ser Gln Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg 
            20                  25                  30          


Leu His Arg Phe Leu Cys Phe Gly Ser Glu Gly Gly Thr Tyr Tyr Ile 
        35                  40                  45              


Lys Glu Gln Lys Leu Gly Leu Glu Asn Ala Glu Ala Leu Ile Arg Leu 
    50                  55                  60                  


Ile Glu Asp Gly Arg Gly Cys Glu Val Ile Gln Glu Ile Lys Ser Phe 
65                  70                  75                  80  


Ser Gln Glu Gly Arg Thr Thr Lys Gln Glu Pro Met Leu Phe Ala Leu 
                85                  90                  95      


Ala Ile Cys Ser Gln Cys Ser Asp Ile Ser Thr Lys Gln Ala Ala Phe 
            100                 105                 110         


Lys Ala Val Ser Glu Val Cys Arg Ile Pro Thr His Leu Phe Thr Phe 
        115                 120                 125             


Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser Met Lys Cys Gly Met Trp 
    130                 135                 140                 


Gly Arg Ala Leu Arg Lys Ala Ile Ala Asp Trp Tyr Asn Glu Lys Gly 
145                 150                 155                 160 


Gly Met Ala Leu Ala Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly 
                165                 170                 175     


Trp Ser His Lys Asp Leu Leu Arg Leu Ser His Leu Lys Pro Ser Ser 
            180                 185                 190         


Glu Gly Leu Ala Ile Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu 
        195                 200                 205             


Val His Glu Leu Tyr Lys Glu Lys Ala Leu Ser Val Glu Thr Glu Lys 
    210                 215                 220                 


Leu Leu Lys Tyr Leu Glu Ala Val Glu Lys Val Lys Arg Thr Arg Asp 
225                 230                 235                 240 


Glu Leu Glu Val Ile His Leu Ile Glu Glu His Arg Leu Val Arg Glu 
                245                 250                 255     


His Leu Leu Thr Asn His Leu Lys Ser Lys Glu Val Trp Lys Ala Leu 
            260                 265                 270         


Leu Gln Glu Met Pro Leu Thr Ala Leu Leu Arg Asn Leu Gly Lys Met 
        275                 280                 285             


Thr Ala Asn Ser Val Leu Glu Pro Gly Asn Ser Glu Val Ser Leu Val 
    290                 295                 300                 


Cys Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His 
305                 310                 315                 320 


Pro Phe His Ile Leu Ile Ala Leu Glu Thr Tyr Lys Thr Gly His Gly 
                325                 330                 335     


Leu Arg Gly Lys Leu Lys Trp Arg Pro Asp Glu Glu Ile Leu Lys Ala 
            340                 345                 350         


Leu Asp Ala Ala Phe Tyr Lys Thr Phe Lys Thr Val Glu Pro Thr Gly 
        355                 360                 365             


Lys Arg Phe Leu Leu Ala Val Asp Val Ser Ala Ser Met Asn Gln Arg 
    370                 375                 380                 


Val Leu Gly Ser Ile Leu Asn Ala Ser Thr Val Ala Ala Ala Met Cys 
385                 390                 395                 400 


Met Val Val Thr Arg Thr Glu Lys Asp Ser Tyr Val Val Ala Phe Ser 
                405                 410                 415     


Asp Glu Met Val Pro Cys Pro Val Thr Thr Asp Met Thr Leu Gln Gln 
            420                 425                 430         


Val Leu Met Ala Met Ser Gln Ile Pro Ala Gly Gly Thr Asp Cys Ser 
        435                 440                 445             


Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro Ala Asp Val Phe 
    450                 455                 460                 


Ile Val Phe Thr Asp Asn Glu Thr Phe Ala Gly Gly Val His Pro Ala 
465                 470                 475                 480 


Ile Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala Lys Leu 
                485                 490                 495     


Ile Val Cys Gly Met Thr Ser Asn Gly Phe Thr Ile Ala Asp Pro Asp 
            500                 505                 510         


Asp Arg Gly Met Leu Asp Met Cys Gly Phe Asp Thr Gly Ala Leu Asp 
        515                 520                 525             


Val Ile Arg Asn Phe Thr Leu Asp Met Ile 
    530                 535             


<210>  21
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
1               5                   10                  15      


Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
            20                  25                  30          


Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
        35                  40                  45              


Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
    50                  55                  60                  


Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
65                  70                  75                  80  


Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                85                  90                  95      


Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
            100                 105                 110         


Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
        115                 120                 125             


Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
    130                 135                 140                 


Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
145                 150                 155                 160 


Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                165                 170                 175     


Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
            180                 185                 190         


Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
        195                 200                 205             


Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
    210                 215                 220                 


Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
225                 230                 235                 240 


Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                245                 250                 255     


Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
            260                 265                 270         


Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
        275                 280                 285             


Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
    290                 295                 300                 


Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
305                 310                 315                 320 


Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                325                 330                 335     


Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
            340                 345                 350         


Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
        355                 360                 365             


Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
    370                 375                 380                 


Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
385                 390                 395                 400 


Thr Glu Asn Gly Ala Gly Asp Gln 
                405             


<210>  22
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  22
guuguauugu uuagcgauu                                                    19


<210>  23
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  23
gcacuagcca ucucuugcuu c                                                 21


<210>  24
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  24
uuuauucaua gccguuaaa                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  25
uuccuuuaaa ucuuccacc                                                    19


<210>  26
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  26
uugagauaac ucacuaccuu cggaccagcc                                        30


<210>  27
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  27
aagacuaguc aagugcagua gugagaag                                          28


<210>  28
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  28
uaaacaccac uacucucgga ccaacc                                            26


<210>  29
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210>  30
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Leu Ser Glu Pro Ile Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Pro Cys Arg Glu Arg Gly Leu Gln Glu Arg Trp Pro Arg Ala Glu Pro 
            20                  25                  30          


Glu Ser Gly Gly Thr Asp Asp Asp Leu Asn Ser Val Leu Asp Phe Ile 
        35                  40                  45              


Leu Ser Met Gly Leu Asp Gly Leu Gly Ala Glu Ala Ala Pro Glu Pro 
    50                  55                  60                  


Pro Pro Pro Pro Pro Pro Pro Ala Phe Tyr Tyr Pro Glu Pro Gly Ala 
65                  70                  75                  80  


Pro Pro Pro Tyr Ser Ala Pro Ala Gly Gly Leu Val Ser Glu Leu Leu 
                85                  90                  95      


Arg Pro Glu Leu Asp Ala Pro Leu Gly Pro Ala Leu His Gly Arg Phe 
            100                 105                 110         


Leu Leu Ala Pro Pro Gly Arg Leu Val Lys Ala Glu Pro Pro Glu Ala 
        115                 120                 125             


Asp Gly Gly Gly Gly Tyr Gly Cys Ala Pro Gly Leu Thr Arg Gly Pro 
    130                 135                 140                 


Arg Gly Leu Lys Arg Glu Gly Ala Pro Gly Pro Ala Ala Ser Cys Met 
145                 150                 155                 160 


Arg Gly Pro Gly Gly Arg Pro Pro Pro Pro Pro Asp Thr Pro Pro Leu 
                165                 170                 175     


Ser Pro Asp Gly Pro Ala Arg Leu Pro Ala Pro Gly Pro Arg Ala Ser 
            180                 185                 190         


Phe Pro Pro Pro Phe Gly Gly Pro Gly Phe Gly Ala Pro Gly Pro Gly 
        195                 200                 205             


Leu His Tyr Ala Pro Pro Ala Pro Pro Ala Phe Gly Leu Phe Asp Asp 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Leu Gly Leu Ala Pro Pro Ala Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Thr Pro Pro Ala Ser Pro Leu Glu Leu Leu Glu Ala Lys 
                245                 250                 255     


Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His 
            260                 265                 270         


Thr Cys Ser Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His 
        275                 280                 285             


Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys 
    290                 295                 300                 


Asn Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr 
305                 310                 315                 320 


Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln Cys His Leu 
                325                 330                 335     


Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys 
            340                 345                 350         


Arg His Met 
        355 


<210>  31
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Met Asn Arg Phe Arg Lys Trp Leu Tyr Lys Pro Lys Arg Ser Asp 
1               5                   10                  15      


Pro Gln Leu Leu Ala Arg Phe Tyr Tyr Ala Asp Glu Glu Leu Asn Gln 
            20                  25                  30          


Val Ala Ala Glu Leu Asp Ser Leu Asp Gly Arg Lys Asp Pro Gln Arg 
        35                  40                  45              


Cys Thr Leu Leu Val Ser Gln Phe Arg Ser Cys Gln Asp Asn Val Leu 
    50                  55                  60                  


Asn Ile Ile Asn Gln Ile Met Asp Glu Cys Ile Pro Gln Asp Arg Ala 
65                  70                  75                  80  


Pro Arg Asp Phe Cys Val Lys Phe Pro Glu Glu Ile Arg His Asp Asn 
                85                  90                  95      


Leu Ala Gly Gln Leu Trp Phe Gly Ala Glu Cys Leu Ala Ala Gly Ser 
            100                 105                 110         


Ile Ile Met Asn Arg Glu Leu Glu Ser Met Ala Met Arg Pro Leu Ala 
        115                 120                 125             


Lys Glu Leu Thr Arg Ser Leu Glu Asp Val Arg Gly Ala Leu Arg Asp 
    130                 135                 140                 


Gln Ala Leu Arg Asp Leu Asn Thr Tyr Thr Glu Lys Met Arg Glu Ala 
145                 150                 155                 160 


Leu Arg His Phe Asp Val Leu Phe Ala Glu Phe Glu Leu Ser Tyr Val 
                165                 170                 175     


Ser Ala Met Val Pro Val Lys Ser Pro Arg Glu Tyr Tyr Val Gln Gln 
            180                 185                 190         


Glu Val Ile Val Leu Phe Cys Glu Thr Val Glu Arg Ala Leu Asp Phe 
        195                 200                 205             


Gly Tyr Leu Thr Gln Asp Met Ile Asp Asp Tyr Glu Pro Ala Leu Met 
    210                 215                 220                 


Phe Ser Ile Pro Arg Leu Ala Ile Val Cys Gly Leu Val Val Tyr Ala 
225                 230                 235                 240 


Asp Gly Pro Leu Asn Leu Asp Arg Lys Val Glu Asp Met Ser Glu Leu 
                245                 250                 255     


Phe Arg Pro Phe His Thr Leu Leu Arg Lys Ile Arg Asp Leu Leu Gln 
            260                 265                 270         


Thr Leu Thr Glu Glu Glu Leu His Thr Leu Glu Arg Asn Leu Cys Ile 
        275                 280                 285             


Ser Gln Asp Val Glu Phe Pro Ile Arg Ala Asp Val Gln Gly Pro Ala 
    290                 295                 300                 


Ala Leu Ala Pro Ala Leu Ser Ala Pro Leu Pro Pro Glu Gly Pro Leu 
305                 310                 315                 320 


Ser Ala Lys Ala Lys Asp Pro Asp Ala Glu Leu Ala Cys Ser Met Gln 
                325                 330                 335     


Tyr Asp Asp Gln Glu Leu Glu Gln Leu Ser Arg Met Val His Arg Ala 
            340                 345                 350         


Gly Asp Glu Met Ser Ser Leu Leu Ser Pro Pro Ile Ala Cys Gln Ser 
        355                 360                 365             


Pro Ala His Arg Pro Gly Ala Glu Gly Ser Pro Gly Gly Glu Ala Ser 
    370                 375                 380                 


Pro Gly Arg Pro Arg Leu Arg Ser Gly Ser Asp Glu Glu Glu Arg Val 
385                 390                 395                 400 


Phe Phe Met Asp Asp Val Glu Gly Thr Ala Glu Ala Leu Ala Arg Pro 
                405                 410                 415     


Glu Ser Pro Ala Gly Pro Phe Gly Trp Ala Gly Ser Thr Trp Ala Asp 
            420                 425                 430         


Pro Gln Glu Lys Gly Gln Gly Gly Pro Gly Gly Ala Ala Gly Ile Ser 
        435                 440                 445             


Leu Pro Ala Ser Glu Lys Glu Glu Asp Leu Ser Asn Asn Asn Leu Glu 
    450                 455                 460                 


Ala Glu Gly Thr Asp Gly Ala Ser Leu Ala Gly Thr Ser Ser Cys Ser 
465                 470                 475                 480 


Cys Leu Asp Ser Arg Leu His Leu Asp Gly Trp Glu Val Gly Ala Asp 
                485                 490                 495     


Asp Ala Glu Thr Ala Glu Met Ile Ala His Arg Thr Gly Gly Met Lys 
            500                 505                 510         


Leu Ser Ala Thr Val Ile Phe Asn Pro Lys Ser Pro Thr Ser Leu Asp 
        515                 520                 525             


Ser Ala Val Ala Thr Gln Glu Ala Ala Ser Glu Pro Val Ala Glu Gly 
    530                 535                 540                 


Met Asp Gly Gly Pro His Lys Leu Ser Thr Gly Ala Thr Asn Cys Leu 
545                 550                 555                 560 


Leu His Ser Cys Val Cys Cys Gly Ser Cys Gly Asp Ser Arg Glu Asp 
                565                 570                 575     


Val Val Glu Arg Leu Arg Glu Lys Cys Ser Pro Gly Gly Val Ile Gly 
            580                 585                 590         


Ala Ser Tyr Ala Ala Gly Leu Ala Lys Ala Ser Asp Arg Ala Pro Glu 
        595                 600                 605             


Arg Gln Glu Glu Ala Pro Pro Pro Ser Glu Asp Ala Ser Asn Gly Arg 
    610                 615                 620                 


Glu Pro Lys Ala Pro Thr Ser Asp Lys Cys Leu Pro His Thr Ser Gly 
625                 630                 635                 640 


Ser Gln Val Asp Thr Ala Ser Gly Leu Gln Gly Glu Ala Gly Val Ala 
                645                 650                 655     


Gly Gln Gln Glu Pro Glu Ala Arg Glu Leu His Ala Gly Ser Pro Pro 
            660                 665                 670         


Ala His Glu Ala Pro Gln Ala Leu Ser Gly Ser Ser Ser Ser Thr Ala 
        675                 680                 685             


Gly Ser Cys Ser Ser Asp Lys Met Gly Pro Glu Ala Ala Pro Ala Ala 
    690                 695                 700                 


Thr His Ala Ala Pro Gln Ala Thr Arg Glu Lys Ile Arg Ser Arg Phe 
705                 710                 715                 720 


His Gly Ser His Asp Leu Ile His Arg Leu Phe Val Cys Ile Ser Gly 
                725                 730                 735     


Val Ala Asp Gln Leu Gln Thr Asn Tyr Ala Ser Asp Leu Arg Ser Ile 
            740                 745                 750         


Leu Lys Thr Leu Phe Glu Val Met Ala Thr Lys Pro Glu Thr Asp Asp 
        755                 760                 765             


Lys Glu Lys Leu Arg Lys Val Thr Gln Thr Leu Arg Ser Ala Ala Leu 
    770                 775                 780                 


Glu Asp Cys Ala Leu Cys Gln Glu Thr Leu Ser Ser Ser Glu Leu Ala 
785                 790                 795                 800 


Ala Lys Thr Arg Asp Gly Asp Phe Glu Asp Pro Pro Glu Trp Val Pro 
                805                 810                 815     


Asp Glu Ala Cys Gly Phe Cys Thr Ala Cys Lys Ala Pro Phe Thr Val 
            820                 825                 830         


Ile Arg Arg Lys His His Cys Arg Ser Cys Gly Lys Ile Phe Cys Ser 
        835                 840                 845             


Arg Cys Ser Ser His Ser Ala Pro Leu Pro Arg Tyr Gly Gln Val Lys 
    850                 855                 860                 


Pro Val Arg Val Cys Thr His Cys Tyr Met Phe His Val Thr Pro Phe 
865                 870                 875                 880 


Tyr Ser Asp Lys Ala Gly Leu 
                885         


<210>  32
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys 
1               5                   10                  15      


Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala 
            20                  25                  30          


Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg 
        35                  40                  45              


Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His 
    50                  55                  60                  


Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr 
65                  70                  75                  80  


Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp 
                85                  90                  95      


Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg 
            100                 105                 110         


Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser 
        115                 120                 125             


Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr 
    130                 135                 140                 


Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala 
145                 150                 155                 160 


Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser 
                165                 170                 175     


Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe 
            180                 185                 190         


Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg 
        195                 200                 205             


Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys 
    210                 215                 220                 


Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp 
                245                 250                 255     


Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu 
            260                 265                 270         


Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
        275                 280                 285             


Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly 
    290                 295                 300                 


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
305                 310                 315                 320 


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro 
                325                 330                 335     


Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg 
            340                 345                 350         


Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys 
        355                 360                 365             


Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr 
    370                 375                 380                 


Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp 
385                 390                 395                 400 


Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu 
                405                 410                 415     


Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe 
            420                 425                 430         


Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr 
        435                 440                 445             


Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser 
    450                 455                 460                 


Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg 
465                 470                 475                 480 


Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu 
                485                 490                 495     


Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln 
            500                 505                 510         


Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp 
        515                 520                 525             


Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe 
    530                 535                 540                 


Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser 
545                 550                 555                 560 


Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys 
                565                 570                 575     


Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys 
            580                 585                 590         


Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu 
        595                 600                 605             


Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu 
    610                 615                 620                 


Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly 
625                 630                 635                 640 


Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu 
                645                 650                 655     


Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser 
            660                 665                 670         


Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly 
        675                 680                 685             


Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn 
    690                 695                 700                 


Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln 
                725                 730                 735     


Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu 
            740                 745                 750         


Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp 
        755                 760                 765             


Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe 
    770                 775                 780                 


Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys 
785                 790                 795                 800 


Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala 
                805                 810                 815     


Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys 
            820                 825                 830         


Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr 
        835                 840                 845             


Glu Leu Asp Ala Gln Leu His 
    850                 855 


<210>  33
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  34
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Phe Ala Trp Thr Val Leu Leu Leu Gly Pro Leu Gln Leu Cys 
1               5                   10                  15      


Ala Leu Val His Cys Ala Pro Pro Ala Ala Gly Gln Gln Gln Pro Pro 
            20                  25                  30          


Arg Glu Pro Pro Ala Ala Pro Gly Ala Trp Arg Gln Gln Ile Gln Trp 
        35                  40                  45              


Glu Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr 
    50                  55                  60                  


Gln Pro Gln Arg Arg Arg Asp Pro Gly Ala Ala Val Pro Gly Ala Ala 
65                  70                  75                  80  


Asn Ala Ser Ala Gln Gln Pro Arg Thr Pro Ile Leu Leu Ile Arg Asp 
                85                  90                  95      


Asn Arg Thr Ala Ala Ala Arg Thr Arg Thr Ala Gly Ser Ser Gly Val 
            100                 105                 110         


Thr Ala Gly Arg Pro Arg Pro Thr Ala Arg His Trp Phe Gln Ala Gly 
        115                 120                 125             


Tyr Ser Thr Ser Arg Ala Arg Glu Ala Gly Ala Ser Arg Ala Glu Asn 
    130                 135                 140                 


Gln Thr Ala Pro Gly Glu Val Pro Ala Leu Ser Asn Leu Arg Pro Pro 
145                 150                 155                 160 


Ser Arg Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr Lys 
                165                 170                 175     


Tyr Ser Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu Arg 
            180                 185                 190         


Pro Arg Pro Gly Gly Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr Phe 
        195                 200                 205             


Gln Tyr Gly Leu Pro Asp Leu Val Ala Asp Pro Tyr Tyr Ile Gln Ala 
    210                 215                 220                 


Ser Thr Tyr Val Gln Lys Met Ser Met Tyr Asn Leu Arg Cys Ala Ala 
225                 230                 235                 240 


Glu Glu Asn Cys Leu Ala Ser Thr Ala Tyr Arg Ala Asp Val Arg Asp 
                245                 250                 255     


Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn Gln 
            260                 265                 270         


Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu Trp 
        275                 280                 285             


His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His Tyr 
    290                 295                 300                 


Asp Leu Leu Asp Ala Asn Thr Gln Arg Arg Val Ala Glu Gly His Lys 
305                 310                 315                 320 


Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His Arg 
                325                 330                 335     


Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys Tyr 
            340                 345                 350         


Asp Thr Tyr Gly Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr Asp 
        355                 360                 365             


Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser Tyr 
    370                 375                 380                 


Leu Val Pro Glu Ser Asp Tyr Thr Asn Asn Val Val Arg Cys Asp Ile 
385                 390                 395                 400 


Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser Pro 
                405                 410                 415     


Tyr 
    


<210>  35
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Cys Ile Gln Ala Gln Tyr Gly Thr Pro Ala Pro Ser Pro Gly 
1               5                   10                  15      


Pro Arg Asp His Leu Ala Ser Asp Pro Leu Thr Pro Glu Phe Ile Lys 
            20                  25                  30          


Pro Thr Met Asp Leu Ala Ser Pro Glu Ala Ala Pro Ala Ala Pro Thr 
        35                  40                  45              


Ala Leu Pro Ser Phe Ser Thr Phe Met Asp Gly Tyr Thr Gly Glu Phe 
    50                  55                  60                  


Asp Thr Phe Leu Tyr Gln Leu Pro Gly Thr Val Gln Pro Cys Ser Ser 
65                  70                  75                  80  


Ala Ser Ser Ser Ala Ser Ser Thr Ser Ser Ser Ser Ala Thr Ser Pro 
                85                  90                  95      


Ala Ser Ala Ser Phe Lys Phe Glu Asp Phe Gln Val Tyr Gly Cys Tyr 
            100                 105                 110         


Pro Gly Pro Leu Ser Gly Pro Val Asp Glu Ala Leu Ser Ser Ser Gly 
        115                 120                 125             


Ser Asp Tyr Tyr Gly Ser Pro Cys Ser Ala Pro Ser Pro Ser Thr Pro 
    130                 135                 140                 


Ser Phe Gln Pro Pro Gln Leu Ser Pro Trp Asp Gly Ser Phe Gly His 
145                 150                 155                 160 


Phe Ser Pro Ser Gln Thr Tyr Glu Gly Leu Arg Ala Trp Thr Glu Gln 
                165                 170                 175     


Leu Pro Lys Ala Ser Gly Pro Pro Gln Pro Pro Ala Phe Phe Ser Phe 
            180                 185                 190         


Ser Pro Pro Thr Gly Pro Ser Pro Ser Leu Ala Gln Ser Pro Leu Lys 
        195                 200                 205             


Leu Phe Pro Ser Gln Ala Thr His Gln Leu Gly Glu Gly Glu Ser Tyr 
    210                 215                 220                 


Ser Met Pro Thr Ala Phe Pro Gly Leu Ala Pro Thr Ser Pro His Leu 
225                 230                 235                 240 


Glu Gly Ser Gly Ile Leu Asp Thr Pro Val Thr Ser Thr Lys Ala Arg 
                245                 250                 255     


Ser Gly Ala Pro Gly Gly Ser Glu Gly Arg Cys Ala Val Cys Gly Asp 
            260                 265                 270         


Asn Ala Ser Cys Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys 
        275                 280                 285             


Gly Phe Phe Lys Arg Thr Val Gln Lys Asn Ala Lys Tyr Ile Cys Leu 
    290                 295                 300                 


Ala Asn Lys Asp Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln 
305                 310                 315                 320 


Phe Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val 
                325                 330                 335     


Val Arg Thr Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys 
            340                 345                 350         


Pro Lys Gln Pro Pro Asp Ala Ser Pro Ala Asn Leu Leu Thr Ser Leu 
        355                 360                 365             


Val Arg Ala His Leu Asp Ser Gly Pro Ser Thr Ala Lys Leu Asp Tyr 
    370                 375                 380                 


Ser Lys Phe Gln Glu Leu Val Leu Pro His Phe Gly Lys Glu Asp Ala 
385                 390                 395                 400 


Gly Asp Val Gln Gln Phe Tyr Asp Leu Leu Ser Gly Ser Leu Glu Val 
                405                 410                 415     


Ile Arg Lys Trp Ala Glu Lys Ile Pro Gly Phe Ala Glu Leu Ser Pro 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Leu Glu Ser Ala Phe Leu Glu Leu Phe Ile 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Lys Pro Gly Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Ser Gly Leu Val Leu His Arg Leu Gln Cys Ala Arg Gly Phe Gly 
465                 470                 475                 480 


Asp Trp Ile Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu 
                485                 490                 495     


Leu Val Asp Val Pro Ala Phe Ala Cys Leu Ser Ala Leu Val Leu Ile 
            500                 505                 510         


Thr Asp Arg His Gly Leu Gln Glu Pro Arg Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Arg Ile Ala Ser Cys Leu Lys Glu His Val Ala Ala Val Ala Gly 
    530                 535                 540                 


Glu Pro Gln Pro Ala Ser Cys Leu Ser Arg Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Pro Ile Ile Asp Lys Ile Phe 
            580                 585                 590         


Met Asp Thr Leu Pro Phe 
        595             


<210>  36
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  36
gtcgtatcca gtgcagggtc cgaggtattc gcactggata cgacattgag                  50


<210>  37
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  37
gtcgtatcca gtgcagggtc cgaggtattc gcactggata cgacaacacc                  50


<210>  38
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  38
gtcgtatcca gtgcagggtc cgaggtattc gcactggata cgacagttgt                  50


<210>  39
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  39
gtcgtatcca gtgcagggtc cgaggtattc gcactggata cgacagttct                  50


<210>  40
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  40
gtgcagggtc cgaggt                                                       16


<210>  41
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  41
tggtccgaag gtagtgagt                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  42
ttggtccgag agtagtggt                                                    19


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  43
tccgagtgca gtggtgttta                                                   20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  44
ggtccgatgg tagtgggtta t                                                 21


<210>  45
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  45
aaggcgcatc tgcgtacaca cacaggtgag aagcctaagg cgcatctgcg tacacacaca       60

ggtgagaagc ct                                                           72


<210>  46
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  46
aaggcgcatc tgcgtacaca cacagagtga ggacctaagg cgcatctgcg tacacacaca       60

gagtgaggac ct                                                           72


<210>  47
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  47
actcactacc ttcggacca                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  48
agtcaagtgc agtagtgag                                                    19


<210>  49
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  49
ttcaatctgt aactgactg                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  50
accactactc tcggaccaa                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  51
ctggtcaagt gaagcagtg                                                    19


<210>  52
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  52
cccactacca tcggaccag                                                    19


<210>  53
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  53
cgttccaatt ttagtatatg tgctgccgaa gcgagcac                               38


<210>  54
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  54
aguucugaua acccacuacc aucggaccag cc                                     32


<210>  55
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  55
uucagcucga uggauauggu g                                                 21


<210>  56
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  56
cagucaguua cagauugaa                                                    19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  57
caaccaguua cagauuucu                                                    19


