                         SEQUENCE LISTING

<110>  Rojas, Jose  F.
       Lai, Ka-Man Venus
       Murphy, Andrew J.
 
<120>  Humanized IL-15 Animals

<130>  31013 (2200)

<150>  61891013
<151>  2013-10-15

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  1
atccatttag cctttctctg atcactaagt tggacagttg gacagtcttc ctcaaattag       60

cttagactat caaaattata ctgtattttt ggtatttcca gcgatcgctt cagttacaag      120

gctgttgaat gcacagaagc aaggataaca ctgatttttt cactggtcag aataaaaatt      180

attgattgct cttttgctta tagtattc                                         208


<210>  2
<211>  2029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  2
aatgtaacag aatctggatg caaagaatgt gaggaactgg aggaaaaaaa tattaaagaa       60

tttttgcaga gttttgtaca tattgtccaa atgttcatca acacttcttg attgcaattg      120

attcttttta aagtgtttct gttattaaca aacatcactc tgctgcttag acataacaaa      180

acactcggca tttcaaatgt gctgtcaaaa caagtttttc tgtcaagaag atgatcagac      240

cttggatcag atgaactctt agaaatgaag gcagaaaaat gtcattgagt aatatagtga      300

ctatgaactt ctctcagact tactttactc atttttttaa tttattattg aaattgtaca      360

tatttgtgga ataatgtaaa atgttgaata aaaatatgta caagtgttgt tttttaagtt      420

gcactgatat tttacctctt attgcaaaat agcatttgtt taagggtgat agtcaaatta      480

tgtattggtg gggctgggta ccaatgctgc aggtcaacag ctatgctggt aggctcctgc      540

cagtgtggaa ccactgacta ctggctctca ttgacttcct tactaagcat agcaaacaga      600

ggaagaattt gttatcagta agaaaaagaa gaactatatg tgaatcctct tctttatact      660

gtaatttagt tattgatgta taaagcaact gttatgaaat aaagaaattg caataactgg      720

catataatgt ccatcagtaa atcttggtgg tggtggcaat aataaacttc tactgatagg      780

tagaatggtg tgcaagcttg tccaatcacg gattgcaggc cacatgcggc ccaggacaac      840

tttgaatgtg gcccaacaca aattcataaa ctttcataca tctcgttttt agctcatcag      900

ctatcattag cggtagtgta tttaaagtgt ggcccaagac aattcttctt attccaatgt      960

ggcccaggga aatcaaaaga ttggatgccc ctggtataga aaactaatag tgacagtgtt     1020

catatttcat gctttcccaa atacaggtat tttattttca cattcttttt gccatgttta     1080

tataataata aagaaaaacc ctgttgattt gttggagcca ttgttatctg acagaaaata     1140

attgtttata ttttttgcac tacactgtct aaaattagca agctctcttc taatggaact     1200

gtaagaaaga tgaaatattt ttgttttatt ataaatttat ttcaccttaa ttctggtaat     1260

actcactgag tgactgtggg gtgggaaatg atctcttaag aatttgattt ctttctattc     1320

catagtacaa actcgttctc tgttgaaaca ttcttctatc accccagtgc cctatccatg     1380

tacatgtgtt cttattgctc tagtcaaacg gtgcttataa atatctttca gaaagtttag     1440

gagaaatctg tatcctattt gacttccaat aatcatgtat tggctgtcag cttcttacct     1500

actctcagtc cagagaaata gtatttggca gccactcttt aaagtttatg ggttgtggat     1560

tgtggcggtt gatttatttt ttttatttca attgggatag aattttttaa tatacctgta     1620

tttttgtttt gttttatgta gcttttctat tagggagagt aggaaaagtg caccattttc     1680

ttctctaaat ttccagtcca gtctttaggg gaatgttagt cttcctgaga tgggggaagg     1740

aaaatcataa tgccagtcac tttgcaaata atattttata gtgataaatg gttcattttg     1800

gttacatagg catacaagtg ggcttaaaac ttggaattta ccagggctca aaattaaaat     1860

tcttacatta gttactcgat atggatcgct tcagttgatc ttagaaaact caaggcatag     1920

atctgcaacc tcgagataac ttcgtataat gtatgctata cgaagttata tgcatggcct     1980

ccgcgccggg ttttggcgcc tcccgcgggc gcccccctcc tcacggcga                 2029


<210>  3
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  3
cattctcagt attgttttgc caagttctaa ttccatcaga cctcgacctg cagcccctag       60

ataacttcgt ataatgtatg ctatacgaag ttatgctagc gtgatagtcc ttcacggaaa      120

gtacaagaat acacagaaaa ctgctgttta cattagtctt tcacgttttt attttattct      180

cacaaatttt aatgcaatac                                                  200


<210>  4
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine IL-15 precursor polypeptide

<400>  4

Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr 
1               5                   10                  15      


Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
    50                  55                  60                  


Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
            100                 105                 110         


Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
        115                 120                 125             


Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
    130                 135                 140                 


Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  5
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hybrid mouse/human IL-15 precursor polypeptide

<400>  5

Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr 
1               5                   10                  15      


Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  6
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL-15 isoform 1 polypeptide

<400>  6

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: hIL-15 Forward primer

<400>  7
gtaaraagtg atttgaaaaa aattgaagat                                        30


<210>  8
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide: hIL-15 Reverse primer

<400>  8
tacaaaactc tgcaaaaatt ctttaatat                                         29
