                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  CELLOBIOSE DEHYDROGENASE VARIANTS AND POLYNUCLEOTIDES ENCODING 
       SAME

<130>  12626-WO-PCT

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  2355
<212>  DNA
<213>  Humicola insolens

<400>  1
atgaagttcc tcggccgtat tggggcgacc gcccttgcgg cgtcgctgta tctcacatca       60

ggcgccgcgc aagccactgg tgatgcgtac accgactcgg aaacaggcat taagttccag      120

acctggtccc cggatccgca gttcactttt ggccttgccc tgccgccgga tgccctggag      180

aaggatgcca ctgagtacat tggtcttctc cgctgcacca gggccgaccc atccgaccct      240

ggctactgcg gtctctctca tggccaggtc ggccagatga cgcagtcgct gcttctcgtg      300

gcctgggcct acgagaacca ggtctacacg tcgttccgct acgccaccgg ctacaccctc      360

ccgggtctgt acaccggcaa cgctaagctg acccagctct ccgtcaacat caccgacacc      420

agcttcgagc tcatctaccg ctgcgagaac tgcttctcgt gggagcacga aggcagcacc      480

ggatctagct cgacctccca gggctatctc gtcctcggtc gtgcttccgc ccgccgcggc      540

gtcgtcggcc cgacttgccc ggacacggcc acctttggtt tccacgacaa tggcttcggt      600

cagtggggtg ttggtctcga gaatgccgtt tcggagcagt attctgagtg ggcttcgctg      660

ccgggtctga ctgttgagac cacctgcgaa ggatccggcc ctggtgaggc gcagtgcgtg      720

cctgcccctg aggagactta tgactatatt gttgttggtg ctggcgccgg cggtattcct      780

gtcgccgaca agctgagcga ggccggccac aaggttctgc tcatcgagaa gggtcccccg      840

tcgacgggcc gctggcaggg taccatgaag cccgagtggc ttgaaggcac tgacctcact      900

cggttcgatg tgcccggcct ttgcaaccag atctgggttg actcggctgg cattgcctgc      960

actgatactg atcagatggc tggctgcgtc ttgggcggtg gcacggccgt taatgctggc     1020

ctgtggtgga agcccattga cctcgactgg gatgagaact tccctgaggg ctggcactcg     1080

caggatctcg ccgcggcgac cgagcgcgtc tttgagcgca tccccggcac ctggcacccg     1140

tccatggatg gcaagctgta ccgtgacgaa ggctacaagg ttctctccag cggtctggct     1200

gagtctggct ggaaggaggt tgtggccaac gaggttccca acgagaagaa ccgcactttc     1260

gcccacaccc acttcatgtt cgctggcgga gagcgtaacg ggcctcttgc cacttacctg     1320

gtctctgccg atgcccgcga gaacttctcg ctctggacca acactgctgt tcgccgcgct     1380

gtccgcactg gtggcaaggt cacaggtgtc gagctcgagt gcttgactga tggcggctac     1440

agcggcattg ttaagctcaa tgagggcggt ggcgtcatct tctcggccgg tgcctttggt     1500

tcggccaagc tgctcttccg cagcggtatc ggccctgagg atcagctccg cgttgttgcc     1560

tcctctaagg acggagagga cttcatcgac gagaaggact ggattaagct ccccgtcggc     1620

tacaacctga ttgaccacct taacactgac ctcatcctca ctcaccccga tgtcgtcttc     1680

tacgacttct atgaggcctg gaccaccccg atcgaggccg acaagcagct gtaccttgag     1740

cagcgctctg gcatccttgc ccaggctgct cctaacattg gccccatgat gtgggagcag     1800

gtcaccccct cggacggcat tacccgccaa ttccagtgga cggctcgcgt cgagggcgac     1860

agccgcttca ccaactcttc tcatgccatg actctcagcc agtacctcgg ccgtggtgtc     1920

gtgtcgcgcg gtcgcgccac catcacccag ggtctcgtca ccaccgtggc tgagcacccg     1980

tacctccaca acgccggcga caaggaggcc gtcattcagg gcatcaagaa cctcattgag     2040

tctcttaacg tgattcccaa catcacttgg gtcctgccgc ctcctggtag cactgtcgag     2100

gaatacgtcg attcgctcct cgtctccgcc tcggctcgtc gctcgaacca ctggatgggc     2160

acggccaagc tgggtactga tgatggccgc tacggcggta cttcggtcgt cgacctcgac     2220

accaaggtct acggcaccga taacctgttc gtggtggatg cttccatctt ccctggcatg     2280

tcgaccggca acccgtccgc tatgatcgtg attgccgctg agcaggctgc ggagcgcatt     2340

ctgaagctga ggaag                                                      2355


<210>  2
<211>  785
<212>  PRT
<213>  Humicola insolens

<400>  2

Met Lys Phe Leu Gly Arg Ile Gly Ala Thr Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Tyr Leu Thr Ser Gly Ala Ala Gln Ala Thr Gly Asp Ala Tyr Thr Asp 
            20                  25                  30          


Ser Glu Thr Gly Ile Lys Phe Gln Thr Trp Ser Pro Asp Pro Gln Phe 
        35                  40                  45              


Thr Phe Gly Leu Ala Leu Pro Pro Asp Ala Leu Glu Lys Asp Ala Thr 
    50                  55                  60                  


Glu Tyr Ile Gly Leu Leu Arg Cys Thr Arg Ala Asp Pro Ser Asp Pro 
65                  70                  75                  80  


Gly Tyr Cys Gly Leu Ser His Gly Gln Val Gly Gln Met Thr Gln Ser 
                85                  90                  95      


Leu Leu Leu Val Ala Trp Ala Tyr Glu Asn Gln Val Tyr Thr Ser Phe 
            100                 105                 110         


Arg Tyr Ala Thr Gly Tyr Thr Leu Pro Gly Leu Tyr Thr Gly Asn Ala 
        115                 120                 125             


Lys Leu Thr Gln Leu Ser Val Asn Ile Thr Asp Thr Ser Phe Glu Leu 
    130                 135                 140                 


Ile Tyr Arg Cys Glu Asn Cys Phe Ser Trp Glu His Glu Gly Ser Thr 
145                 150                 155                 160 


Gly Ser Ser Ser Thr Ser Gln Gly Tyr Leu Val Leu Gly Arg Ala Ser 
                165                 170                 175     


Ala Arg Arg Gly Val Val Gly Pro Thr Cys Pro Asp Thr Ala Thr Phe 
            180                 185                 190         


Gly Phe His Asp Asn Gly Phe Gly Gln Trp Gly Val Gly Leu Glu Asn 
        195                 200                 205             


Ala Val Ser Glu Gln Tyr Ser Glu Trp Ala Ser Leu Pro Gly Leu Thr 
    210                 215                 220                 


Val Glu Thr Thr Cys Glu Gly Ser Gly Pro Gly Glu Ala Gln Cys Val 
225                 230                 235                 240 


Pro Ala Pro Glu Glu Thr Tyr Asp Tyr Ile Val Val Gly Ala Gly Ala 
                245                 250                 255     


Gly Gly Ile Pro Val Ala Asp Lys Leu Ser Glu Ala Gly His Lys Val 
            260                 265                 270         


Leu Leu Ile Glu Lys Gly Pro Pro Ser Thr Gly Arg Trp Gln Gly Thr 
        275                 280                 285             


Met Lys Pro Glu Trp Leu Glu Gly Thr Asp Leu Thr Arg Phe Asp Val 
    290                 295                 300                 


Pro Gly Leu Cys Asn Gln Ile Trp Val Asp Ser Ala Gly Ile Ala Cys 
305                 310                 315                 320 


Thr Asp Thr Asp Gln Met Ala Gly Cys Val Leu Gly Gly Gly Thr Ala 
                325                 330                 335     


Val Asn Ala Gly Leu Trp Trp Lys Pro Ile Asp Leu Asp Trp Asp Glu 
            340                 345                 350         


Asn Phe Pro Glu Gly Trp His Ser Gln Asp Leu Ala Ala Ala Thr Glu 
        355                 360                 365             


Arg Val Phe Glu Arg Ile Pro Gly Thr Trp His Pro Ser Met Asp Gly 
    370                 375                 380                 


Lys Leu Tyr Arg Asp Glu Gly Tyr Lys Val Leu Ser Ser Gly Leu Ala 
385                 390                 395                 400 


Glu Ser Gly Trp Lys Glu Val Val Ala Asn Glu Val Pro Asn Glu Lys 
                405                 410                 415     


Asn Arg Thr Phe Ala His Thr His Phe Met Phe Ala Gly Gly Glu Arg 
            420                 425                 430         


Asn Gly Pro Leu Ala Thr Tyr Leu Val Ser Ala Asp Ala Arg Glu Asn 
        435                 440                 445             


Phe Ser Leu Trp Thr Asn Thr Ala Val Arg Arg Ala Val Arg Thr Gly 
    450                 455                 460                 


Gly Lys Val Thr Gly Val Glu Leu Glu Cys Leu Thr Asp Gly Gly Tyr 
465                 470                 475                 480 


Ser Gly Ile Val Lys Leu Asn Glu Gly Gly Gly Val Ile Phe Ser Ala 
                485                 490                 495     


Gly Ala Phe Gly Ser Ala Lys Leu Leu Phe Arg Ser Gly Ile Gly Pro 
            500                 505                 510         


Glu Asp Gln Leu Arg Val Val Ala Ser Ser Lys Asp Gly Glu Asp Phe 
        515                 520                 525             


Ile Asp Glu Lys Asp Trp Ile Lys Leu Pro Val Gly Tyr Asn Leu Ile 
    530                 535                 540                 


Asp His Leu Asn Thr Asp Leu Ile Leu Thr His Pro Asp Val Val Phe 
545                 550                 555                 560 


Tyr Asp Phe Tyr Glu Ala Trp Thr Thr Pro Ile Glu Ala Asp Lys Gln 
                565                 570                 575     


Leu Tyr Leu Glu Gln Arg Ser Gly Ile Leu Ala Gln Ala Ala Pro Asn 
            580                 585                 590         


Ile Gly Pro Met Met Trp Glu Gln Val Thr Pro Ser Asp Gly Ile Thr 
        595                 600                 605             


Arg Gln Phe Gln Trp Thr Ala Arg Val Glu Gly Asp Ser Arg Phe Thr 
    610                 615                 620                 


Asn Ser Ser His Ala Met Thr Leu Ser Gln Tyr Leu Gly Arg Gly Val 
625                 630                 635                 640 


Val Ser Arg Gly Arg Ala Thr Ile Thr Gln Gly Leu Val Thr Thr Val 
                645                 650                 655     


Ala Glu His Pro Tyr Leu His Asn Ala Gly Asp Lys Glu Ala Val Ile 
            660                 665                 670         


Gln Gly Ile Lys Asn Leu Ile Glu Ser Leu Asn Val Ile Pro Asn Ile 
        675                 680                 685             


Thr Trp Val Leu Pro Pro Pro Gly Ser Thr Val Glu Glu Tyr Val Asp 
    690                 695                 700                 


Ser Leu Leu Val Ser Ala Ser Ala Arg Arg Ser Asn His Trp Met Gly 
705                 710                 715                 720 


Thr Ala Lys Leu Gly Thr Asp Asp Gly Arg Tyr Gly Gly Thr Ser Val 
                725                 730                 735     


Val Asp Leu Asp Thr Lys Val Tyr Gly Thr Asp Asn Leu Phe Val Val 
            740                 745                 750         


Asp Ala Ser Ile Phe Pro Gly Met Ser Thr Gly Asn Pro Ser Ala Met 
        755                 760                 765             


Ile Val Ile Ala Ala Glu Gln Ala Ala Glu Arg Ile Leu Lys Leu Arg 
    770                 775                 780                 


Lys 
785 


<210>  3
<211>  762
<212>  PRT
<213>  Humicola insolens

<400>  3

Gln Ala Thr Gly Asp Ala Tyr Thr Asp Ser Glu Thr Gly Ile Lys Phe 
1               5                   10                  15      


Gln Thr Trp Ser Pro Asp Pro Gln Phe Thr Phe Gly Leu Ala Leu Pro 
            20                  25                  30          


Pro Asp Ala Leu Glu Lys Asp Ala Thr Glu Tyr Ile Gly Leu Leu Arg 
        35                  40                  45              


Cys Thr Arg Ala Asp Pro Ser Asp Pro Gly Tyr Cys Gly Leu Ser His 
    50                  55                  60                  


Gly Gln Val Gly Gln Met Thr Gln Ser Leu Leu Leu Val Ala Trp Ala 
65                  70                  75                  80  


Tyr Glu Asn Gln Val Tyr Thr Ser Phe Arg Tyr Ala Thr Gly Tyr Thr 
                85                  90                  95      


Leu Pro Gly Leu Tyr Thr Gly Asn Ala Lys Leu Thr Gln Leu Ser Val 
            100                 105                 110         


Asn Ile Thr Asp Thr Ser Phe Glu Leu Ile Tyr Arg Cys Glu Asn Cys 
        115                 120                 125             


Phe Ser Trp Glu His Glu Gly Ser Thr Gly Ser Ser Ser Thr Ser Gln 
    130                 135                 140                 


Gly Tyr Leu Val Leu Gly Arg Ala Ser Ala Arg Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Thr Cys Pro Asp Thr Ala Thr Phe Gly Phe His Asp Asn Gly Phe 
                165                 170                 175     


Gly Gln Trp Gly Val Gly Leu Glu Asn Ala Val Ser Glu Gln Tyr Ser 
            180                 185                 190         


Glu Trp Ala Ser Leu Pro Gly Leu Thr Val Glu Thr Thr Cys Glu Gly 
        195                 200                 205             


Ser Gly Pro Gly Glu Ala Gln Cys Val Pro Ala Pro Glu Glu Thr Tyr 
    210                 215                 220                 


Asp Tyr Ile Val Val Gly Ala Gly Ala Gly Gly Ile Pro Val Ala Asp 
225                 230                 235                 240 


Lys Leu Ser Glu Ala Gly His Lys Val Leu Leu Ile Glu Lys Gly Pro 
                245                 250                 255     


Pro Ser Thr Gly Arg Trp Gln Gly Thr Met Lys Pro Glu Trp Leu Glu 
            260                 265                 270         


Gly Thr Asp Leu Thr Arg Phe Asp Val Pro Gly Leu Cys Asn Gln Ile 
        275                 280                 285             


Trp Val Asp Ser Ala Gly Ile Ala Cys Thr Asp Thr Asp Gln Met Ala 
    290                 295                 300                 


Gly Cys Val Leu Gly Gly Gly Thr Ala Val Asn Ala Gly Leu Trp Trp 
305                 310                 315                 320 


Lys Pro Ile Asp Leu Asp Trp Asp Glu Asn Phe Pro Glu Gly Trp His 
                325                 330                 335     


Ser Gln Asp Leu Ala Ala Ala Thr Glu Arg Val Phe Glu Arg Ile Pro 
            340                 345                 350         


Gly Thr Trp His Pro Ser Met Asp Gly Lys Leu Tyr Arg Asp Glu Gly 
        355                 360                 365             


Tyr Lys Val Leu Ser Ser Gly Leu Ala Glu Ser Gly Trp Lys Glu Val 
    370                 375                 380                 


Val Ala Asn Glu Val Pro Asn Glu Lys Asn Arg Thr Phe Ala His Thr 
385                 390                 395                 400 


His Phe Met Phe Ala Gly Gly Glu Arg Asn Gly Pro Leu Ala Thr Tyr 
                405                 410                 415     


Leu Val Ser Ala Asp Ala Arg Glu Asn Phe Ser Leu Trp Thr Asn Thr 
            420                 425                 430         


Ala Val Arg Arg Ala Val Arg Thr Gly Gly Lys Val Thr Gly Val Glu 
        435                 440                 445             


Leu Glu Cys Leu Thr Asp Gly Gly Tyr Ser Gly Ile Val Lys Leu Asn 
    450                 455                 460                 


Glu Gly Gly Gly Val Ile Phe Ser Ala Gly Ala Phe Gly Ser Ala Lys 
465                 470                 475                 480 


Leu Leu Phe Arg Ser Gly Ile Gly Pro Glu Asp Gln Leu Arg Val Val 
                485                 490                 495     


Ala Ser Ser Lys Asp Gly Glu Asp Phe Ile Asp Glu Lys Asp Trp Ile 
            500                 505                 510         


Lys Leu Pro Val Gly Tyr Asn Leu Ile Asp His Leu Asn Thr Asp Leu 
        515                 520                 525             


Ile Leu Thr His Pro Asp Val Val Phe Tyr Asp Phe Tyr Glu Ala Trp 
    530                 535                 540                 


Thr Thr Pro Ile Glu Ala Asp Lys Gln Leu Tyr Leu Glu Gln Arg Ser 
545                 550                 555                 560 


Gly Ile Leu Ala Gln Ala Ala Pro Asn Ile Gly Pro Met Met Trp Glu 
                565                 570                 575     


Gln Val Thr Pro Ser Asp Gly Ile Thr Arg Gln Phe Gln Trp Thr Ala 
            580                 585                 590         


Arg Val Glu Gly Asp Ser Arg Phe Thr Asn Ser Ser His Ala Met Thr 
        595                 600                 605             


Leu Ser Gln Tyr Leu Gly Arg Gly Val Val Ser Arg Gly Arg Ala Thr 
    610                 615                 620                 


Ile Thr Gln Gly Leu Val Thr Thr Val Ala Glu His Pro Tyr Leu His 
625                 630                 635                 640 


Asn Ala Gly Asp Lys Glu Ala Val Ile Gln Gly Ile Lys Asn Leu Ile 
                645                 650                 655     


Glu Ser Leu Asn Val Ile Pro Asn Ile Thr Trp Val Leu Pro Pro Pro 
            660                 665                 670         


Gly Ser Thr Val Glu Glu Tyr Val Asp Ser Leu Leu Val Ser Ala Ser 
        675                 680                 685             


Ala Arg Arg Ser Asn His Trp Met Gly Thr Ala Lys Leu Gly Thr Asp 
    690                 695                 700                 


Asp Gly Arg Tyr Gly Gly Thr Ser Val Val Asp Leu Asp Thr Lys Val 
705                 710                 715                 720 


Tyr Gly Thr Asp Asn Leu Phe Val Val Asp Ala Ser Ile Phe Pro Gly 
                725                 730                 735     


Met Ser Thr Gly Asn Pro Ser Ala Met Ile Val Ile Ala Ala Glu Gln 
            740                 745                 750         


Ala Ala Glu Arg Ile Leu Lys Leu Arg Lys 
        755                 760         


