                         SEQUENCE LISTING

<110>  Felder, Bejamin
 
<120>  Chimeric antigen receptors with antigen binding domains derived 
       from gamma delta T cell receptors

<130>  F30769WO

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  2

Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Gly Lys 
1               5                   10                  15      


<210>  3
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      


Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          


Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              


Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  


Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys Lys Ile Lys Val 
            100                 105                 110         


Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr 
        115                 120         


<210>  4
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly 
1               5                   10                  15      


Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
            20                  25                  30          


Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
        35                  40                  45              


Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
    50                  55                  60                  


Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
65                  70                  75                  80  


Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
                85                  90                  95      


Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
            100                 105                 110         


Cys Asp Ala Leu Lys Arg Thr Asp Thr Asp Lys Leu Ile Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Val Thr Val Glu 
    130                 135 


<210>  5
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr Lys Thr Leu Ser 
1               5                   10                  15      


Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile Thr Ile Ser Ala 
            20                  25                  30          


Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu Val Ile Gln Phe 
        35                  40                  45              


Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys Glu Ser Gly Ile 
    50                  55                  60                  


Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu Thr Ser Thr Ser 
65                  70                  75                  80  


Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys Lys Ile Lys Val 
            100                 105                 110         


Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Gly Ser Ala Asp Asp Ala 
        115                 120                 125             


Lys Lys Asp Ala Ala Lys Lys Asp Gly Lys Met Gln Arg Ile Ser Ser 
    130                 135                 140                 


Leu Ile His Leu Ser Leu Phe Trp Ala Gly Val Met Ser Ala Ile Glu 
145                 150                 155                 160 


Leu Val Pro Glu His Gln Thr Val Pro Val Ser Ile Gly Val Pro Ala 
                165                 170                 175     


Thr Leu Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn Tyr Tyr Ile 
            180                 185                 190         


Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr Met Thr Phe Ile Tyr Arg 
        195                 200                 205             


Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe Gln Gly Asp 
    210                 215                 220                 


Ile Asp Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu Ala Pro Ser 
225                 230                 235                 240 


Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Ala Leu Lys Arg 
                245                 250                 255     


Gly Gly Glu Tyr Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val 
            260                 265                 270         


Thr Val Glu 
        275 


<210>  6
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu 
        35                  40                  45              


Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys 
    50                  55                  60                  


Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys 
65                  70                  75                  80  


Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys 
                85                  90                  95      


Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
            100                 105                 110         


Ile Thr Met Asp Pro Lys Asp Asn 
        115                 120 


<210>  7
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr 
1               5                   10                  15      


Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile 
            20                  25                  30          


Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val 
        35                  40                  45              


Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu 
    50                  55                  60                  


Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val 
65                  70                  75                  80  


His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys 
                85                  90                  95      


Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys 
            100                 105                 110         


Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
        115                 120                 125             


Val 
    


<210>  8
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         


<210>  9
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  10
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  11
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  12
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  13
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutation of SEQ ID NO. 12, wherein LL to GG

<400>  13

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  14
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  15
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of SEQ ID NO. 13, 11 and 14

<400>  15

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        35                  40                  45              


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
                85                  90                  95      


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            100                 105                 110         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        115                 120                 125             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    130                 135                 140                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Leu Tyr Leu Leu Arg 
145                 150                 155                 160 


Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
                165                 170                 175     


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
            180                 185                 190         


Leu Ala Lys Ile 
        195     


<210>  16
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of signal peptide, V delta 2, C delta, CD28 transmembrane 
       and ICD, CD3 zeta, OX40 ICD

<400>  16

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Met Gln Arg Ile Ser Ser Leu Ile 
            20                  25                  30          


His Leu Ser Leu Phe Trp Ala Gly Val Met Ser Ala Ile Glu Leu Val 
        35                  40                  45              


Pro Glu His Gln Thr Val Pro Val Ser Ile Gly Val Pro Ala Thr Leu 
    50                  55                  60                  


Arg Cys Ser Met Lys Gly Glu Ala Ile Gly Asn Tyr Tyr Ile Asn Trp 
65                  70                  75                  80  


Tyr Arg Lys Thr Gln Gly Asn Thr Met Thr Phe Ile Tyr Arg Glu Lys 
                85                  90                  95      


Asp Ile Tyr Gly Pro Gly Phe Lys Asp Asn Phe Gln Gly Asp Ile Asp 
            100                 105                 110         


Ile Ala Lys Asn Leu Ala Val Leu Lys Ile Leu Ala Pro Ser Glu Arg 
        115                 120                 125             


Asp Glu Gly Ser Tyr Tyr Cys Ala Cys Asp Ala Leu Lys Arg Thr Asp 
    130                 135                 140                 


Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Ser 
145                 150                 155                 160 


Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn 
                165                 170                 175     


Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn 
            180                 185                 190         


Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile 
        195                 200                 205             


Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp 
    210                 215                 220                 


Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His 
225                 230                 235                 240 


Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro 
                245                 250                 255     


Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro 
            260                 265                 270         


Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu 
465                 470                 475                 480 


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
                485                 490                 495     


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
            500                 505                 510     


<210>  17
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of signal peptide, V gamma 9, C gamma, CD28 transmembrane 
       and ICD, CD3 zeta and OX40 ICD

<400>  17

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Ala Gly His Leu Glu Gln Pro Gln 
            20                  25                  30          


Ile Ser Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val 
        35                  40                  45              


Val Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
    50                  55                  60                  


Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly 
65                  70                  75                  80  


Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp 
                85                  90                  95      


Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu 
            100                 105                 110         


Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ala Gln Gln 
        115                 120                 125             


Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile 
    130                 135                 140                 


Ile Thr Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile 
145                 150                 155                 160 


Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                165                 170                 175     


Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp 
            180                 185                 190         


Glu Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr 
        195                 200                 205             


Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro 
    210                 215                 220                 


Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn 
225                 230                 235                 240 


Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr 
                245                 250                 255     


Asp Val Ile Thr Met Asp Pro Lys Asp Asn Phe Trp Val Leu Val Val 
            260                 265                 270         


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        275                 280                 285             


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp 
    290                 295                 300                 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
305                 310                 315                 320 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
                325                 330                 335     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            340                 345                 350         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        355                 360                 365             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
    370                 375                 380                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
385                 390                 395                 400 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                405                 410                 415     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            420                 425                 430         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala 
        435                 440                 445             


Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys 
    450                 455                 460                 


Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
465                 470                 475                 480 


Asp Ala His Ser Thr Leu Ala Lys Ile 
                485                 


<210>  18
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion of signal peptide, V gamma 9 - L V delta 2, C delta, CD28 
       transmembrane and ICD, CD3 zeta and OX40 ICD

<400>  18

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Ala Gly His Leu Glu Gln Pro Gln 
            20                  25                  30          


Ile Ser Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val 
        35                  40                  45              


Val Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
    50                  55                  60                  


Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly 
65                  70                  75                  80  


Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp 
                85                  90                  95      


Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu 
            100                 105                 110         


Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ala Gln Gln 
        115                 120                 125             


Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile 
    130                 135                 140                 


Ile Thr Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp 
145                 150                 155                 160 


Gly Lys Met Gln Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp 
                165                 170                 175     


Ala Gly Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val 
            180                 185                 190         


Pro Val Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly 
        195                 200                 205             


Glu Ala Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly 
    210                 215                 220                 


Asn Thr Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly 
225                 230                 235                 240 


Phe Lys Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala 
                245                 250                 255     


Val Leu Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr 
            260                 265                 270         


Cys Ala Cys Asp Ala Leu Lys Arg Gly Gly Glu Tyr Thr Asp Lys Leu 
        275                 280                 285             


Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Ser Gln Pro His Thr 
    290                 295                 300                 


Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu 
305                 310                 315                 320 


Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser 
                325                 330                 335     


Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly 
            340                 345                 350         


Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val 
        355                 360                 365             


Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe 
    370                 375                 380                 


Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu 
385                 390                 395                 400 


Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val 
                405                 410                 415     


His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Phe Trp Val Leu 
            420                 425                 430         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        435                 440                 445             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Gly Gly His 
    450                 455                 460                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
465                 470                 475                 480 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                485                 490                 495     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            500                 505                 510         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        515                 520                 525             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    530                 535                 540                 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
545                 550                 555                 560 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                565                 570                 575     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            580                 585                 590         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        595                 600                 605             


Arg Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
    610                 615                 620                 


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
625                 630                 635                 640 


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                645                 650     


<210>  19
<211>  1540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding protein of SEQ ID NO. 16

<400>  19
atgccatcca gcgtctcatg gggtatcctt ctgctcgccg gattatgctg tctcgtgcca       60

gtatccctgg ccatgcaacg catttcgtct ctcatccact tgtccctctt ctgggccggg      120

gttatgagtg ctattgagtt agtaccagaa caccaaactg tcccagtgtc cataggcgtt      180

cccgccaccc tccggtgttc aatgaaggga gaagccatag gaaattacta cattaactgg      240

tacagaaaga ctcaggggaa cactatgacc ttcatctata gggagaaaga catctacggg      300

ccaggtttca aagacaattt tcagggcgac attgatatcg caaagaacct ggctgtgcta      360

aaaatactcg caccatcgga gcgcgacgag gggtcctact actgtgcctg tgatgcactc      420

aagcggacgg ataccgacaa gcttatcttt gggaagggga ccagggtcac agtggagtct      480

cagccgcata ctaagccttc agtgttcgtg atgaagaatg gcacaaatgt cgcttgtcta      540

gttaaagaat tttaccctaa agacataagg attaatctgg tgtcaagcaa aaaaatcaca      600

gaattcgacc cagctatagt tatctcccca tccggaaaat acaatgccgt aaaactgggt      660

aagtacgagg attcaaattc agtcacgtgc tcggtgcaac atgataacaa aactgtgcac      720

tcaacggatt tcgaggtcaa gacagattca accgaccacg tgaaaccgaa ggaaaccgag      780

aacacaaagc agccttcaaa gagttgtcac aagccaaagg ctattgttca caccgagaaa      840

gtgaacatga tgtctctgac cgtattttgg gtgctcgtgg tcgtaggggg agtgctcgcg      900

tgctattctc tgctcgtgac agtcgccttc atcatttttt gggtgaggag taaacgatcg      960

cgcggcggcc actcagacta catgaacatg actccccgaa gacctggccc gacaaggaaa     1020

cactaccagc cctacgcacc ccctagagat ttcgctgctt accggtcacg agtgaagttt     1080

tcaagaagtg ccgacgcgcc cgcttaccag cagggccaga accagctgta caatgagctg     1140

aacctcggac ggcgagagga gtatgatgtg ctggacaagc gccgtggccg agatcctgaa     1200

atgggcggga agccccagag gagaaagaat ccccaggaag gcctgtacaa cgagctccag     1260

aaggacaaaa tggcggaagc ctattcagaa atcggaatga agggcgaacg ccgcagagga     1320

aaggggcatg acgggctcta tcagggattg tctaccgcaa ccaaagatac ttacgatgct     1380

ctccacatgc aggcccttcc accaagagcc ctatatctgt tgcgtcgcga ccagcgcctt     1440

ccgcccgatg ctcacaagcc gccaggcggt gggagcttca gaactcccat tcaggaggag     1500

caggcagacg cccacagcac actggcaaaa atctagtaaa                           1540


<210>  20
<211>  1474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding protein of SEQ ID NO. 17

<400>  20
atgccatcat ctgtcagttg ggggatccta ctgcttgctg gcctctgctg tctcgtgcca       60

gtgtcgctag ccgctggcca cctggagcag cctcagatct catccacgaa gactctgtct      120

aagaccgccc ggttagagtg tgtggtttca ggcatcacga taagcgcgac ttcagtttat      180

tggtaccgcg agaggccggg cgaggtaatc cagtttctgg tcagtataag ctatgacggt      240

accgtgcgga aggaaagtgg aatccctagc gggaagtttg aggtggaccg catccctgaa      300

accagcactt ctaccctgac tattcacaac gtggaaaagc aggatatcgc tacttattac      360

tgcgcattgt gggaggcaca gcaggaatta gggaaaaaga tcaaagtctt cgggcctggt      420

accaaactca tcatcacaga caaacaactg gatgccgacg tgagccccaa gcccacgatc      480

tttctgccat ctattgcgga gacaaagctt cagaaagctg ggacatatct ctgcctgctt      540

gaaaagtttt tccctgacgt gattaagatt cattgggagg aaaagaagag taacaccatc      600

ttgggaagtc aggagggtaa caccatgaaa accaatgaca cctatatgaa gttctcatgg      660

cttacagttc ccgagaagag ccttgacaag gagcacaggt gtatagtgcg gcacgagaat      720

aacaaaaacg gagtggacca agaaattatc ttccctccta tcaagacaga cgttattacc      780

atggatccca aggataactt ctgggtactg gttgtagtgg gcggagtgct ggcctgctat      840

tcattgctgg tgaccgtggc ctttatcata ttctgggtta ggtccaaaag aagcaggggc      900

ggccatagcg actacatgaa catgacacca cgcagacctg gccctacacg caaacactac      960

caaccatacg caccaccgcg tgacttcgcg gcctaccgta gtagagtgaa gttttcccgt     1020

agcgccgatg cccccgcata tcagcagggg cagaaccagc tgtacaacga gctgaatctg     1080

ggacgccgag aggagtacga tgtcttggac aaacggcgag gccgtgatcc tgagatgggc     1140

ggaaagccgc aacggagaaa gaatccccag gaaggcctct acaacgaatt gcagaaggat     1200

aaaatggcag aggcgtattc tgaaattggt atgaagggcg agcgacgcag gggtaaagga     1260

cacgatggct tataccaggg cctttccacg gcaactaaag atacttatga cgcgctgcac     1320

atgcaggctc tgcctccccg cgccctgtat ctgctccgac gtgaccagag actgccaccc     1380

gacgcccaca aaccgcccgg tggcggctca ttccgtacac cgatccagga ggaacaggcc     1440

gacgcccact ccactttagc aaaaatctag taaa                                 1474


<210>  21
<211>  1960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding protein of SEQ ID NO. 18

<400>  21
atgccatctt ccgtaagttg gggcattttg ctgctggcgg gcctgtgttg cctcgtgcca       60

gtgagcctcg cagccgggca cctagagcaa cctcagatca gcagcacgaa gaccctttca      120

aaaaccgctc gtctcgagtg tgtggtgagc ggtataacaa tttctgccac tagtgtctac      180

tggtatcggg agaggcctgg cgaagtcatc cagtttttag tctccatcag ttatgacggt      240

acagttcgca aggaaagcgg gatacccagc ggaaagtttg aggtggatag aatacccgag      300

acttcaacca gcaccttaac aattcataat gtcgaaaaac aggatatcgc tacttactat      360

tgcgctttat gggaagctca gcaggagctg gggaagaaga ttaaggtttt tggtcctgga      420

acaaaactga ttattacagg gtctgcggat gacgctaaaa aggacgccgc gaaaaaggac      480

ggaaagatgc agcgaattag ctccctgatc cacctctcct tgttctgggc aggcgtaatg      540

tccgcaatcg aactcgtgcc tgagcatcag accgtgccgg taagtattgg ggtgccagca      600

actctaagat gtagtatgaa gggtgaagca atcgggaact actacatcaa ttggtataga      660

aaaacccaag gtaacacaat gaccttcatc taccgggaaa aagatatata cgggccggga      720

ttcaaggaca acttccaagg ggacatagat atcgcaaaaa acctcgctgt gctgaaaatc      780

ctggctccct cggaaaggga cgagggctca tactactgcg cttgcgatgc tctgaagcgc      840

ggaggcgaat acaccgacaa gctgatcttc ggaaaaggga cacgagtcac cgtggaaagt      900

cagccacaca ctaagccttc cgttttcgtg atgaagaacg gtacaaacgt ggcttgcctc      960

gtaaaagaat tttacccaaa ggatatcagg ataaacctgg tgtcgtcaaa gaaaatcaca     1020

gagttcgacc cagccattgt catctcccca tcaggcaagt acaatgccgt caaacttggg     1080

aagtatgagg actcaaactc agttacatgc tctgttcagc atgacaataa aacagtgcat     1140

tctaccgact ttgaggtgaa gacggactcg actgatcacg ttaagcccaa ggagactgaa     1200

aacactaagc agccaagcaa gtcatgccat aaaccgaagg cgatagtgca caccgagaag     1260

gtcaacatga tgtccctgac tgtgttttgg gtgctcgtcg tggttggcgg agtgctggcg     1320

tgttatagcc tgctggtgac cgttgccttc atcatcttct gggtgcgctc caaaagaagc     1380

cggggtggtc actctgacta catgaatatg acccccaggc gtcccggtcc cacaagaaag     1440

cactaccagc catatgcgcc ccctcgagac ttcgccgcct atcgaagcag agtgaagttc     1500

tccaggtcag ccgacgcacc cgcatatcaa cagggacaga accagttata caatgagctt     1560

aacctcggcc ggcgcgaaga atacgatgtc ttggacaagc ggcgtgggag ggaccctgag     1620

atgggcggga agcctcagag gcgaaagaac ccacaggagg gactttataa tgagctccaa     1680

aaggataaaa tggctgaagc ctacagcgag atcgggatga agggggaacg taggagagga     1740

aaagggcatg acgggctcta tcagggcctg agtaccgcca ccaaagatac ttatgatgcc     1800

ttgcacatgc aggcgctgcc tcctcgagca ttgtatctgc tgagaagaga tcaaaggctc     1860

cctccagatg cacacaaacc gccaggcgga ggtagcttca gaacaccaat tcaagaagaa     1920

caggccgatg cacacagtac cctagcaaag atctagtaaa                           1960


<210>  22
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys Lys Ile Lys Val Phe 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Cys Asp Thr Leu Gly Met Gly Gly Glu Tyr Thr Asp Lys Leu Ile 
1               5                   10                  15      


