                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       Tel Hashomer Medical Research Infrastructure and Services 
       Ltd.
 
<120>  Interleukin-1 (Il-1) Inhibitors for Treating Fertility Disorders

<130>  2311291

<150>  US 61/897,990
<151>  2013-10-31

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer (Human Interleukin-1 alpha )

<400>  1
ttggttgagg gaatcattca t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Interleukin-1 alpha )

<400>  2
tccataaccc atgatctgga a                                                 21


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer (Human Interleukin-1 beta )

<400>  3
gtggcagcta cctgtgtct                                                    19


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Interleukin-1 beta)

<400>  4
gagcctgtag tgcagttgtc t                                                 21


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer (Human Interleukin-1 receptor type )

<400>  5
ctctgctgtc gctggagatt                                                   20


<210>  6
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Interleukin-1 receptor type 1)

<400>  6
gaaggtggcc tgtgtgc                                                      17


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer ( Human Glyceraldehyde 3-Phosphate Dehydrogenase 
       (GAPDH, G3PDH)

<400>  7
gtgaaggtcg gtgtgaacgg                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Glyceraldehyde 3-Phosphate Dehydrogenase 
       (GAPDH, G3PDH)

<400>  8
gtgatggcat ggactgtggt c                                                 21


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer  (Human Follicle-Stimulating Hormone Receptor (FSH
       receptor, FSHR)

<400>  9
agtgtttaat gcctgtgttg ga                                                22


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Follicle-Stimulating Hormone Receptor (FSH 
       receptor, FSHR)

<400>  10
accctgaggc cttccaga                                                     18


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer  (Human BCL2-associated X protein (BAX)

<400>  11
ggtcccgaag taggagagga                                                   20


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer  (Human BCL2-associated X protein (BAX)

<400>  12
gaaccatcat gggctgga                                                     18


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer  (Human B-cell lymphoma 2 (Bcl-2)

<400>  13
gctgagcagg gtcttcagag                                                   20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer  (Human B-cell lymphoma 2 (Bcl-2)

<400>  14
gtacctgaac cggcatctg                                                    19


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer (Human Interleukin 6 (IL-6)

<400>  15
agccagagtc cttcagag                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer  (Human Interleukin 6 (IL-6)

<400>  16
ccactccttc tgtgactc                                                     18


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer  (Human Interleukin 10 (IL-10)

<400>  17
gttgtccagc tggtcctttg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Interleukin 10 (IL-10)

<400>  18
cagccgggaa gacaataact                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer (Human Tumor Necrosis Factor alpha (TNF alpha, 
       TNF, cachexin, or cachectin)

<400>  19
gaggccattt gggaacttct                                                   20


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Tumor Necrosis Factor alpha (TNF alpha, 
       TNF, cachexin, or cachectin)

<400>  20
tgcctatgtc tcagcctctt c                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer  (Human Interleukin-1 beta )

<400>  21
tcttctttgg gtattgcttg g                                                 21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer  (Human Interleukin-1 beta)

<400>  22
tgtaatgaaa gacggcacac c                                                 21


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer  (Human Hypoxanthine-Guanine 
       Phosphoribosyltransferase 1 (HGPRT-1)

<400>  23
ctggttcatc atcgctaatc ac                                                22


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer (Human Hypoxanthine-Guanine 
       Phosphoribosyltransferase 1 (HGPRT-1)

<400>  24
ggagcggtag cacctcct                                                     18


<210>  25
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210>  26
<211>  2943
<212>  DNA
<213>  Homo sapiens

<400>  26
accaggcaac accattgaag gctcatatgt aaaaatccat gccttccttt ctcccaatct       60

ccattcccaa acttagccac tggcttctgg ctgaggcctt acgcatacct cccggggctt      120

gcacacacct tcttctacag aagacacacc ttgggcatat cctacagaag accaggcttc      180

tctctggtcc ttggtagagg gctactttac tgtaacaggg ccagggtgga gagttctctc      240

ctgaagctcc atcccctcta taggaaatgt gttgacaata ttcagaagag taagaggatc      300

aagacttctt tgtgctcaaa taccactgtt ctcttctcta ccctgcccta accaggagct      360

tgtcacccca aactctgagg tgatttatgc cttaatcaag caaacttccc tcttcagaaa      420

agatggctca ttttccctca aaagttgcca ggagctgcca agtattctgc caattcaccc      480

tggagcacaa tcaacaaatt cagccagaac acaactacag ctactattag aactattatt      540

attaataaat tcctctccaa atctagcccc ttgacttcgg atttcacgat ttctcccttc      600

ctcctagaaa cttgataagt ttcccgcgct tccctttttc taagactaca tgtttgtcat      660

cttataaagc aaaggggtga ataaatgaac caaatcaata acttctggaa tatctgcaaa      720

caacaataat atcagctatg ccatctttca ctattttagc cagtatcgag ttgaatgaac      780

atagaaaaat acaaaactga attcttccct gtaaattccc cgttttgacg acgcacttgt      840

agccacgtag ccacgcctac ttaagacaat tacaaaaggc gaagaagact gactcaggct      900

taagctgcca gccagagagg gagtcatttc attggcgttt gagtcagcaa agaagtcaag      960

atggccaaag ttccagacat gtttgaagac ctgaagaact gttacagtga aaatgaagaa     1020

gacagttcct ccattgatca tctgtctctg aatcagaaat ccttctatca tgtaagctat     1080

ggcccactcc atgaaggctg catggatcaa tctgtgtctc tgagtatctc tgaaacctct     1140

aaaacatcca agcttacctt caaggagagc atggtggtag tagcaaccaa cgggaaggtt     1200

ctgaagaaga gacggttgag tttaagccaa tccatcactg atgatgacct ggaggccatc     1260

gccaatgact cagaggaaga aatcatcaag cctaggtcag caccttttag cttcctgagc     1320

aatgtgaaat acaactttat gaggatcatc aaatacgaat tcatcctgaa tgacgccctc     1380

aatcaaagta taattcgagc caatgatcag tacctcacgg ctgctgcatt acataatctg     1440

gatgaagcag tgaaatttga catgggtgct tataagtcat caaaggatga tgctaaaatt     1500

accgtgattc taagaatctc aaaaactcaa ttgtatgtga ctgcccaaga tgaagaccaa     1560

ccagtgctgc tgaaggagat gcctgagata cccaaaacca tcacaggtag tgagaccaac     1620

ctcctcttct tctgggaaac tcacggcact aagaactatt tcacatcagt tgcccatcca     1680

aacttgttta ttgccacaaa gcaagactac tgggtgtgct tggcaggggg gccaccctct     1740

atcactgact ttcagatact ggaaaaccag gcgtaggtct ggagtctcac ttgtctcact     1800

tgtgcagtgt tgacagttca tatgtaccat gtacatgaag aagctaaatc ctttactgtt     1860

agtcatttgc tgagcatgta ctgagccttg taattctaaa tgaatgttta cactctttgt     1920

aagagtggaa ccaacactaa catataatgt tgttatttaa agaacaccct atattttgca     1980

tagtaccaat cattttaatt attattcttc ataacaattt taggaggacc agagctactg     2040

actatggcta ccaaaaagac tctacccata ttacagatgg gcaaattaag gcataagaaa     2100

actaagaaat atgcacaata gcagttgaaa caagaagcca cagacctagg atttcatgat     2160

ttcatttcaa ctgtttgcct tctactttta agttgctgat gaactcttaa tcaaatagca     2220

taagtttctg ggacctcagt tttatcattt tcaaaatgga gggaataata cctaagcctt     2280

cctgccgcaa cagtttttta tgctaatcag ggaggtcatt ttggtaaaat acttcttgaa     2340

gccgagcctc aagatgaagg caaagcacga aatgttattt tttaattatt atttatatat     2400

gtatttataa atatatttaa gataattata atatactata tttatgggaa ccccttcatc     2460

ctctgagtgt gaccaggcat cctccacaat agcagacagt gttttctggg ataagtaagt     2520

ttgatttcat taatacaggg cattttggtc caagttgtgc ttatcccata gccaggaaac     2580

tctgcattct agtacttggg agacctgtaa tcatataata aatgtacatt aattaccttg     2640

agccagtaat tggtccgatc tttgactctt ttgccattaa acttacctgg gcattcttgt     2700

ttcaattcca cctgcaatca agtcctacaa gctaaaatta gatgaactca actttgacaa     2760

ccatgagacc actgttatca aaactttctt ttctggaatg taatcaatgt ttcttctagg     2820

ttctaaaaat tgtgatcaga ccataatgtt acattattat caacaatagt gattgataga     2880

gtgttatcag tcataactaa ataaagcttg caacaaaatt ctctgacaaa aaaaaaaaaa     2940

aaa                                                                   2943


<210>  27
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  28
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  28
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag       1498


<210>  29
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  30
<211>  5170
<212>  DNA
<213>  Homo sapiens

<400>  30
gtggccggcg gccggagccg actcggagcg cgcggcgccg gccgggagga gccggagagc       60

ggccgggccg ggcggtgggg gcgccggcct gccccgcgcg ccccagggag cggcaggaat      120

gtgacaatcg cgcgcccgcg caccgaagca ctcctcgctc ggctcctagg gctctcgccc      180

ctctgagctg agccgggttc cgcccggggc tgggatccca tcaccctcca cggccgtccg      240

tccaggtaga cgcaccctct gaagatggtg actccctcct gagaagctgg accccttggt      300

aaaagacaag gccttctcca agaagaatat gaaagtgtta ctcagactta tttgtttcat      360

agctctactg atttcttctc tggaggctga taaatgcaag gaacgtgaag aaaaaataat      420

tttagtgtca tctgcaaatg aaattgatgt tcgtccctgt cctcttaacc caaatgaaca      480

caaaggcact ataacttggt ataaagatga cagcaagaca cctgtatcta cagaacaagc      540

ctccaggatt catcaacaca aagagaaact ttggtttgtt cctgctaagg tggaggattc      600

aggacattac tattgcgtgg taagaaattc atcttactgc ctcagaatta aaataagtgc      660

aaaatttgtg gagaatgagc ctaacttatg ttataatgca caagccatat ttaagcagaa      720

actacccgtt gcaggagacg gaggacttgt gtgcccttat atggagtttt ttaaaaatga      780

aaataatgag ttacctaaat tacagtggta taaggattgc aaacctctac ttcttgacaa      840

tatacacttt agtggagtca aagataggct catcgtgatg aatgtggctg aaaagcatag      900

agggaactat acttgtcatg catcctacac atacttgggc aagcaatatc ctattacccg      960

ggtaatagaa tttattactc tagaggaaaa caaacccaca aggcctgtga ttgtgagccc     1020

agctaatgag acaatggaag tagacttggg atcccagata caattgatct gtaatgtcac     1080

cggccagttg agtgacattg cttactggaa gtggaatggg tcagtaattg atgaagatga     1140

cccagtgcta ggggaagact attacagtgt ggaaaatcct gcaaacaaaa gaaggagtac     1200

cctcatcaca gtgcttaata tatcggaaat tgaaagtaga ttttataaac atccatttac     1260

ctgttttgcc aagaatacac atggtataga tgcagcatat atccagttaa tatatccagt     1320

cactaatttc cagaagcaca tgattggtat atgtgtcacg ttgacagtca taattgtgtg     1380

ttctgttttc atctataaaa tcttcaagat tgacattgtg ctttggtaca gggattcctg     1440

ctatgatttt ctcccaataa aagcttcaga tggaaagacc tatgacgcat atatactgta     1500

tccaaagact gttggggaag ggtctacctc tgactgtgat atttttgtgt ttaaagtctt     1560

gcctgaggtc ttggaaaaac agtgtggata taagctgttc atttatggaa gggatgacta     1620

cgttggggaa gacattgttg aggtcattaa tgaaaacgta aagaaaagca gaagactgat     1680

tatcatttta gtcagagaaa catcaggctt cagctggctg ggtggttcat ctgaagagca     1740

aatagccatg tataatgctc ttgttcagga tggaattaaa gttgtcctgc ttgagctgga     1800

gaaaatccaa gactatgaga aaatgccaga atcgattaaa ttcattaagc agaaacatgg     1860

ggctatccgc tggtcagggg actttacaca gggaccacag tctgcaaaga caaggttctg     1920

gaagaatgtc aggtaccaca tgccagtcca gcgacggtca ccttcatcta aacaccagtt     1980

actgtcacca gccactaagg agaaactgca aagagaggct cacgtgcctc tcgggtagca     2040

tggagaagtt gccaagagtt ctttaggtgc ctcctgtctt atggcgttgc aggccaggtt     2100

atgcctcatg ctgacttgca gagttcatgg aatgtaacta tatcatcctt tatccctgag     2160

gtcacctgga atcagattat taagggaata agccatgacg tcaatagcag cccagggcac     2220

ttcagagtag agggcttggg aagatctttt aaaaaggcag taggcccggt gtggtggctc     2280

acgcctataa tcccagcact ttgggaggct gaagtgggtg gatcaccaga ggtcaggagt     2340

tcgagaccag cccagccaac atggcaaaac cccatctcta ctaaaaatac aaaaatgagc     2400

taggcatggt ggcacacgcc tgtaatccca gctacacctg aggctgaggc aggagaattg     2460

cttgaaccgg ggagacggag gttgcagtga gccgagtttg ggccactgca ctctagcctg     2520

gcaacagagc aagactccgt ctcaaaaaaa gggcaataaa tgccctctct gaatgtttga     2580

actgccaaga aaaggcatgg agacagcgaa ctagaagaaa gggcaagaag gaaatagcca     2640

ccgtctacag atggcttagt taagtcatcc acagcccaag ggcggggcta tgccttgtct     2700

ggggaccctg tagagtcact gaccctggag cggctctcct gagaggtgct gcaggcaaag     2760

tgagactgac acctcactga ggaagggaga catattcttg gagaactttc catctgcttg     2820

tattttccat acacatcccc agccagaagt tagtgtccga agaccgaatt ttattttaca     2880

gagcttgaaa actcacttca atgaacaaag ggattctcca ggattccaaa gttttgaagt     2940

catcttagct ttccacagga gggagagaac ttaaaaaagc aacagtagca gggaattgat     3000

ccacttctta atgctttcct ccctggcatg accatcctgt cctttgttat tatcctgcat     3060

tttacgtctt tggaggaaca gctccctagt ggcttcctcc gtctgcaatg tcccttgcac     3120

agcccacaca tgaaccatcc ttcccatgat gccgctcttc tgtcatcccg ctcctgctga     3180

aacacctccc aggggctcca cctgttcagg agctgaagcc catgctttcc caccagcatg     3240

tcactcccag accacctccc tgccctgtcc tccagcttcc cctcgctgtc ctgctgtgtg     3300

aattcccagg ttggcctggt ggccatgtcg cctgccccca gcactcctct gtctctgctc     3360

ttgcctgcac ccttcctcct cctttgccta ggaggccttc tcgcattttc tctagctgat     3420

cagaatttta ccaaaattca gaacatcctc caattccaca gtctctggga gactttccct     3480

aagaggcgac ttcctctcca gccttctctc tctggtcagg cccactgcag agatggtggt     3540

gagcacatct gggaggctgg tctccctcca gctggaattg ctgctctctg agggagaggc     3600

tgtggtggct gtctctgtcc ctcactgcct tccaggagca atttgcacat gtaacataga     3660

tttatgtaat gctttatgtt taaaaacatt ccccaattat cttatttaat ttttgcaatt     3720

attctaattt tatatataga gaaagtgacc tattttttaa aaaaatcaca ctctaagttc     3780

tattgaacct aggacttgag cctccatttc tggcttctag tctggtgttc tgagtacttg     3840

atttcaggtc aataacggtc ccccctcact ccacactggc acgtttgtga gaagaaatga     3900

cattttgcta ggaagtgacc gagtctagga atgcttttat tcaagacacc aaattccaaa     3960

cttctaaatg ttggaatttt caaaaattgt gtttagattt tatgaaaaac tcttctactt     4020

tcatctattc tttccctaga ggcaaacatt tcttaaaatg tttcattttc attaaaaatg     4080

aaagccaaat ttatatgcca ccgattgcag gacacaagca cagttttaag agttgtatga     4140

acatggagag gacttttggt ttttatattt ctcgtattta atatgggtga acaccaactt     4200

ttatttggaa taataatttt cctcctaaac aaaaacacat tgagtttaag tctctgactc     4260

ttgcctttcc acctgctttc tcctgggccc gctttgcctg cttgaaggaa cagtgctgtt     4320

ctggagctgc tgttccaaca gacagggcct agctttcatt tgacacacag actacagcca     4380

gaagcccatg gagcagggat gtcacgtctt gaaaagccta ttagatgttt tacaaattta     4440

attttgcaga ttattttagt ctgtcatcca gaaaatgtgt cagcatgcat agtgctaaga     4500

aagcaagcca atttggaaac ttaggttagt gacaaaattg gccagagagt gggggtgatg     4560

atgaccaaga attacaagta gaatggcagc tggaatttaa ggagggacaa gaatcaatgg     4620

ataagcgtgg gtggaggaag atccaaacag aaaagtgcaa agttattccc catcttccaa     4680

gggttgaatt ctggaggaag aagacacatt cctagttccc cgtgaacttc ctttgactta     4740

ttgtccccac taaaacaaaa caaaaaactt ttaatgcctt ccacattaat tagattttct     4800

tgcagttttt ttatggcatt tttttaaaga tgccctaagt gttgaagaag agtttgcaaa     4860

tgcaacaaaa tatttaatta ccggttgtta aaactggttt agcacaattt atattttccc     4920

tctcttgcct ttcttatttg caataaaagg tattgagcca ttttttaaat gacatttttg     4980

ataaattatg tttgtactag ttgatgaagg agtttttttt aacctgttta tataattttg     5040

cagcagaagc caaatttttt gtatattaaa gcaccaaatt catgtacagc atgcatcacg     5100

gatcaataga ctgtacttat tttccaataa aattttcaaa ctttgtactg ttaaaaaaaa     5160

aaaaaaaaaa                                                            5170


<210>  31
<211>  4990
<212>  DNA
<213>  Homo sapiens

<400>  31
attggcagct cttcacttgt atcttttcat atcaaaaatg ggaggtgaca cccagtttaa       60

ggaaaattcc aaggcatttg tctcgactaa tgtgaaagat gattacagtg gccagaggac      120

tgccaaggct ccttctcaag ctgcttgagt caatgagggt agacgcaccc tctgaagatg      180

gtgactccct cctgagaagc tggacccctt ggtaaaagac aaggccttct ccaagaagaa      240

tatgaaagtg ttactcagac ttatttgttt catagctcta ctgatttctt ctctggaggc      300

tgataaatgc aaggaacgtg aagaaaaaat aattttagtg tcatctgcaa atgaaattga      360

tgttcgtccc tgtcctctta acccaaatga acacaaaggc actataactt ggtataaaga      420

tgacagcaag acacctgtat ctacagaaca agcctccagg attcatcaac acaaagagaa      480

actttggttt gttcctgcta aggtggagga ttcaggacat tactattgcg tggtaagaaa      540

ttcatcttac tgcctcagaa ttaaaataag tgcaaaattt gtggagaatg agcctaactt      600

atgttataat gcacaagcca tatttaagca gaaactaccc gttgcaggag acggaggact      660

tgtgtgccct tatatggagt tttttaaaaa tgaaaataat gagttaccta aattacagtg      720

gtataaggat tgcaaacctc tacttcttga caatatacac tttagtggag tcaaagatag      780

gctcatcgtg atgaatgtgg ctgaaaagca tagagggaac tatacttgtc atgcatccta      840

cacatacttg ggcaagcaat atcctattac ccgggtaata gaatttatta ctctagagga      900

aaacaaaccc acaaggcctg tgattgtgag cccagctaat gagacaatgg aagtagactt      960

gggatcccag atacaattga tctgtaatgt caccggccag ttgagtgaca ttgcttactg     1020

gaagtggaat gggtcagtaa ttgatgaaga tgacccagtg ctaggggaag actattacag     1080

tgtggaaaat cctgcaaaca aaagaaggag taccctcatc acagtgctta atatatcgga     1140

aattgaaagt agattttata aacatccatt tacctgtttt gccaagaata cacatggtat     1200

agatgcagca tatatccagt taatatatcc agtcactaat ttccagaagc acatgattgg     1260

tatatgtgtc acgttgacag tcataattgt gtgttctgtt ttcatctata aaatcttcaa     1320

gattgacatt gtgctttggt acagggattc ctgctatgat tttctcccaa taaaagtctt     1380

gcctgaggtc ttggaaaaac agtgtggata taagctgttc atttatggaa gggatgacta     1440

cgttggggaa gacattgttg aggtcattaa tgaaaacgta aagaaaagca gaagactgat     1500

tatcatttta gtcagagaaa catcaggctt cagctggctg ggtggttcat ctgaagagca     1560

aatagccatg tataatgctc ttgttcagga tggaattaaa gttgtcctgc ttgagctgga     1620

gaaaatccaa gactatgaga aaatgccaga atcgattaaa ttcattaagc agaaacatgg     1680

ggctatccgc tggtcagggg actttacaca gggaccacag tctgcaaaga caaggttctg     1740

gaagaatgtc aggtaccaca tgccagtcca gcgacggtca ccttcatcta aacaccagtt     1800

actgtcacca gccactaagg agaaactgca aagagaggct cacgtgcctc tcgggtagca     1860

tggagaagtt gccaagagtt ctttaggtgc ctcctgtctt atggcgttgc aggccaggtt     1920

atgcctcatg ctgacttgca gagttcatgg aatgtaacta tatcatcctt tatccctgag     1980

gtcacctgga atcagattat taagggaata agccatgacg tcaatagcag cccagggcac     2040

ttcagagtag agggcttggg aagatctttt aaaaaggcag taggcccggt gtggtggctc     2100

acgcctataa tcccagcact ttgggaggct gaagtgggtg gatcaccaga ggtcaggagt     2160

tcgagaccag cccagccaac atggcaaaac cccatctcta ctaaaaatac aaaaatgagc     2220

taggcatggt ggcacacgcc tgtaatccca gctacacctg aggctgaggc aggagaattg     2280

cttgaaccgg ggagacggag gttgcagtga gccgagtttg ggccactgca ctctagcctg     2340

gcaacagagc aagactccgt ctcaaaaaaa gggcaataaa tgccctctct gaatgtttga     2400

actgccaaga aaaggcatgg agacagcgaa ctagaagaaa gggcaagaag gaaatagcca     2460

ccgtctacag atggcttagt taagtcatcc acagcccaag ggcggggcta tgccttgtct     2520

ggggaccctg tagagtcact gaccctggag cggctctcct gagaggtgct gcaggcaaag     2580

tgagactgac acctcactga ggaagggaga catattcttg gagaactttc catctgcttg     2640

tattttccat acacatcccc agccagaagt tagtgtccga agaccgaatt ttattttaca     2700

gagcttgaaa actcacttca atgaacaaag ggattctcca ggattccaaa gttttgaagt     2760

catcttagct ttccacagga gggagagaac ttaaaaaagc aacagtagca gggaattgat     2820

ccacttctta atgctttcct ccctggcatg accatcctgt cctttgttat tatcctgcat     2880

tttacgtctt tggaggaaca gctccctagt ggcttcctcc gtctgcaatg tcccttgcac     2940

agcccacaca tgaaccatcc ttcccatgat gccgctcttc tgtcatcccg ctcctgctga     3000

aacacctccc aggggctcca cctgttcagg agctgaagcc catgctttcc caccagcatg     3060

tcactcccag accacctccc tgccctgtcc tccagcttcc cctcgctgtc ctgctgtgtg     3120

aattcccagg ttggcctggt ggccatgtcg cctgccccca gcactcctct gtctctgctc     3180

ttgcctgcac ccttcctcct cctttgccta ggaggccttc tcgcattttc tctagctgat     3240

cagaatttta ccaaaattca gaacatcctc caattccaca gtctctggga gactttccct     3300

aagaggcgac ttcctctcca gccttctctc tctggtcagg cccactgcag agatggtggt     3360

gagcacatct gggaggctgg tctccctcca gctggaattg ctgctctctg agggagaggc     3420

tgtggtggct gtctctgtcc ctcactgcct tccaggagca atttgcacat gtaacataga     3480

tttatgtaat gctttatgtt taaaaacatt ccccaattat cttatttaat ttttgcaatt     3540

attctaattt tatatataga gaaagtgacc tattttttaa aaaaatcaca ctctaagttc     3600

tattgaacct aggacttgag cctccatttc tggcttctag tctggtgttc tgagtacttg     3660

atttcaggtc aataacggtc ccccctcact ccacactggc acgtttgtga gaagaaatga     3720

cattttgcta ggaagtgacc gagtctagga atgcttttat tcaagacacc aaattccaaa     3780

cttctaaatg ttggaatttt caaaaattgt gtttagattt tatgaaaaac tcttctactt     3840

tcatctattc tttccctaga ggcaaacatt tcttaaaatg tttcattttc attaaaaatg     3900

aaagccaaat ttatatgcca ccgattgcag gacacaagca cagttttaag agttgtatga     3960

acatggagag gacttttggt ttttatattt ctcgtattta atatgggtga acaccaactt     4020

ttatttggaa taataatttt cctcctaaac aaaaacacat tgagtttaag tctctgactc     4080

ttgcctttcc acctgctttc tcctgggccc gctttgcctg cttgaaggaa cagtgctgtt     4140

ctggagctgc tgttccaaca gacagggcct agctttcatt tgacacacag actacagcca     4200

gaagcccatg gagcagggat gtcacgtctt gaaaagccta ttagatgttt tacaaattta     4260

attttgcaga ttattttagt ctgtcatcca gaaaatgtgt cagcatgcat agtgctaaga     4320

aagcaagcca atttggaaac ttaggttagt gacaaaattg gccagagagt gggggtgatg     4380

atgaccaaga attacaagta gaatggcagc tggaatttaa ggagggacaa gaatcaatgg     4440

ataagcgtgg gtggaggaag atccaaacag aaaagtgcaa agttattccc catcttccaa     4500

gggttgaatt ctggaggaag aagacacatt cctagttccc cgtgaacttc ctttgactta     4560

ttgtccccac taaaacaaaa caaaaaactt ttaatgcctt ccacattaat tagattttct     4620

tgcagttttt ttatggcatt tttttaaaga tgccctaagt gttgaagaag agtttgcaaa     4680

tgcaacaaaa tatttaatta ccggttgtta aaactggttt agcacaattt atattttccc     4740

tctcttgcct ttcttatttg caataaaagg tattgagcca ttttttaaat gacatttttg     4800

ataaattatg tttgtactag ttgatgaagg agtttttttt aacctgttta tataattttg     4860

cagcagaagc caaatttttt gtatattaaa gcaccaaatt catgtacagc atgcatcacg     4920

gatcaataga ctgtacttat tttccaataa aattttcaaa ctttgtactg ttaaaaaaaa     4980

aaaaaaaaaa                                                            4990


<210>  32
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  33
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln 
    290                 295     


<210>  34
<211>  1484
<212>  DNA
<213>  Homo sapiens

<400>  34
cccgtgagga ggaaaaggtg tgtccgctgc cacccagtgt gagcgggtga caccacccgg       60

ttaggaaatc ccagctccca agagggtata aatccctgct ttactgctga gctcctgctg      120

gaggtgaaag tctggcctgg cagccttccc caggtgagca gcaacaaggc cacgtgctgc      180

tgggtctcag tcctccactt cccgtgtcct ctggaagttg tcaggagcaa tgttgcgctt      240

gtacgtgttg gtaatgggag tttctgcctt cacccttcag cctgcggcac acacaggggc      300

tgccagaagc tgccggtttc gtgggaggca ttacaagcgg gagttcaggc tggaagggga      360

gcctgtagcc ctgaggtgcc cccaggtgcc ctactggttg tgggcctctg tcagcccccg      420

catcaacctg acatggcata aaaatgactc tgctaggacg gtcccaggag aagaagagac      480

acggatgtgg gcccaggacg gtgctctgtg gcttctgcca gccttgcagg aggactctgg      540

cacctacgtc tgcactacta gaaatgcttc ttactgtgac aaaatgtcca ttgagctcag      600

agtttttgag aatacagatg ctttcctgcc gttcatctca tacccgcaaa ttttaacctt      660

gtcaacctct ggggtattag tatgccctga cctgagtgaa ttcacccgtg acaaaactga      720

cgtgaagatt caatggtaca aggattctct tcttttggat aaagacaatg agaaatttct      780

aagtgtgagg gggaccactc acttactcgt acacgatgtg gccctggaag atgctggcta      840

ttaccgctgt gtcctgacat ttgcccatga aggccagcaa tacaacatca ctaggagtat      900

tgagctacgc atcaagaaaa aaaaagaaga gaccattcct gtgatcattt cccccctcaa      960

gaccatatca gcttctctgg ggtcaagact gacaatcccg tgtaaggtgt ttctgggaac     1020

cggcacaccc ttaaccacca tgctgtggtg gacggccaat gacacccaca tagagagcgc     1080

ctacccggga ggccgcgtga ccgaggggcc acgccaggaa tattcagaaa ataatgagaa     1140

ctacattgaa gtgccattga tttttgatcc tgtcacaaga gaggatttgc acatggattt     1200

taaatgtgtt gtccataata ccctgagttt tcagacacta cgcaccacag tcaaggaagc     1260

ctcctccacg ttctcctggg gcattgtgct ggccccactt tcactggcct tcttggtttt     1320

ggggggaata tggatgcaca gacggtgcaa acacagaact ggaaaagcag atggtctgac     1380

tgtgctatgg cctcatcatc aagactttca atcctatccc aagtgaaata aatggaatga     1440

aataattcaa acacaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1484


<210>  35
<211>  1204
<212>  DNA
<213>  Homo sapiens

<400>  35
cccgtgagga ggaaaaggtg tgtccgctgc cacccagtgt gagcgggtga caccacccgg       60

ttaggaaatc ccagctccca agagggtata aatccctgct ttactgctga gctcctgctg      120

gaggtgaaag tctggcctgg cagccttccc caggtgagca gcaacaaggc cacgtgctgc      180

tgggtctcag tcctccactt cccgtgtcct ctggaagttg tcaggagcaa tgttgcgctt      240

gtacgtgttg gtaatgggag tttctgcctt cacccttcag cctgcggcac acacaggggc      300

tgccagaagc tgccggtttc gtgggaggca ttacaagcgg gagttcaggc tggaagggga      360

gcctgtagcc ctgaggtgcc cccaggtgcc ctactggttg tgggcctctg tcagcccccg      420

catcaacctg acatggcata aaaatgactc tgctaggacg gtcccaggag aagaagagac      480

acggatgtgg gcccaggacg gtgctctgtg gcttctgcca gccttgcagg aggactctgg      540

cacctacgtc tgcactacta gaaatgcttc ttactgtgac aaaatgtcca ttgagctcag      600

agtttttgag aatacagatg ctttcctgcc gttcatctca tacccgcaaa ttttaacctt      660

gtcaacctct ggggtattag tatgccctga cctgagtgaa ttcacccgtg acaaaactga      720

cgtgaagatt caatggtaca aggattctct tcttttggat aaagacaatg agaaatttct      780

aagtgtgagg gggaccactc acttactcgt acacgatgtg gccctggaag atgctggcta      840

ttaccgctgt gtcctgacat ttgcccatga aggccagcaa tacaacatca ctaggagtat      900

tgagctacgc atcaagaaaa aaaaagaaga gaccattcct gtgatcattt cccccctcaa      960

gaccatatca gcttctctgg ggtcaagact gacaatcccg tgtaaggtgt ttctgggaac     1020

cggcacaccc ttaaccacca tgctgtggtg gacggccaat gacacccaca tagagagcgc     1080

ctacccggga ggccgcgtga ccgaggggcc acgccagtaa gtgggccagg gtcttctgtt     1140

gagaactctg tgggtttcgc tcttcctttt ggagacagtt atcactatga cccacatacc     1200

acat                                                                  1204


<210>  36
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  37
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 


<210>  38
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  39
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             


<210>  40
<211>  1794
<212>  DNA
<213>  Homo sapiens

<400>  40
atttctttat aaaccacaac tctgggcccg caatggcagt ccactgcctt gctgcagtca       60

cagaatggaa atctgcagag gcctccgcag tcacctaatc actctcctcc tcttcctgtt      120

ccattcagag acgatctgcc gaccctctgg gagaaaatcc agcaagatgc aagccttcag      180

aatctgggat gttaaccaga agaccttcta tctgaggaac aaccaactag ttgctggata      240

cttgcaagga ccaaatgtca atttagaaga aaagatagat gtggtaccca ttgagcctca      300

tgctctgttc ttgggaatcc atggagggaa gatgtgcctg tcctgtgtca agtctggtga      360

tgagaccaga ctccagctgg aggcagttaa catcactgac ctgagcgaga acagaaagca      420

ggacaagcgc ttcgccttca tccgctcaga cagtggcccc accaccagtt ttgagtctgc      480

cgcctgcccc ggttggttcc tctgcacagc gatggaagct gaccagcccg tcagcctcac      540

caatatgcct gacgaaggcg tcatggtcac caaattctac ttccaggagg acgagtagta      600

ctgcccaggc ctgcctgttc ccattcttgc atggcaagga ctgcagggac tgccagtccc      660

cctgccccag ggctcccggc tatgggggca ctgaggacca gccattgagg ggtggaccct      720

cagaaggcgt cacaacaacc tggtcacagg actctgcctc ctcttcaact gaccagcctc      780

catgctgcct ccagaatggt ctttctaatg tgtgaatcag agcacagcag cccctgcaca      840

aagcccttcc atgtcgcctc tgcattcagg atcaaacccc gaccacctgc ccaacctgct      900

ctcctcttgc cactgcctct tcctccctca ttccaccttc ccatgccctg gatccatcag      960

gccacttgat gacccccaac caagtggctc ccacaccctg ttttacaaaa aagaaaagac     1020

cagtccatga gggaggtttt taagggtttg tggaaaatga aaattaggat ttcatgattt     1080

ttttttttca gtccccgtga aggagagccc ttcatttgga gattatgttc tttcggggag     1140

aggctgagga cttaaaatat tcctgcattt gtgaaatgat ggtgaaagta agtggtagct     1200

tttcccttct ttttcttctt tttttgtgat gtcccaactt gtaaaaatta aaagttatgg     1260

tactatgtta gccccataat tttttttttc cttttaaaac acttccataa tctggactcc     1320

tctgtccagg cactgctgcc cagcctccaa gctccatctc cactccagat tttttacagc     1380

tgcctgcagt actttacctc ctatcagaag tttctcagct cccaaggctc tgagcaaatg     1440

tggctcctgg gggttctttc ttcctctgct gaaggaataa attgctcctt gacattgtag     1500

agcttctggc acttggagac ttgtatgaaa gatggctgtg cctctgcctg tctcccccac     1560

cgggctggga gctctgcaga gcaggaaaca tgactcgtat atgtctcagg tccctgcagg     1620

gccaagcacc tagcctcgct cttggcaggt actcagcgaa tgaatgctgt atatgttggg     1680

tgcaaagttc cctacttcct gtgacttcag ctctgtttta caataaaatc ttgaaaatgc     1740

ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           1794


<210>  41
<211>  1865
<212>  DNA
<213>  Homo sapiens

<400>  41
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg       60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc      120

ctccccatgg ctttagctga cttgtatgaa gaaggaggtg gaggaggagg agaaggtgaa      180

gacaatgctg actcaaagga gacgatctgc cgaccctctg ggagaaaatc cagcaagatg      240

caagccttca gaatctggga tgttaaccag aagaccttct atctgaggaa caaccaacta      300

gttgctggat acttgcaagg accaaatgtc aatttagaag aaaagataga tgtggtaccc      360

attgagcctc atgctctgtt cttgggaatc catggaggga agatgtgcct gtcctgtgtc      420

aagtctggtg atgagaccag actccagctg gaggcagtta acatcactga cctgagcgag      480

aacagaaagc aggacaagcg cttcgccttc atccgctcag acagtggccc caccaccagt      540

tttgagtctg ccgcctgccc cggttggttc ctctgcacag cgatggaagc tgaccagccc      600

gtcagcctca ccaatatgcc tgacgaaggc gtcatggtca ccaaattcta cttccaggag      660

gacgagtagt actgcccagg cctgcctgtt cccattcttg catggcaagg actgcaggga      720

ctgccagtcc ccctgcccca gggctcccgg ctatgggggc actgaggacc agccattgag      780

gggtggaccc tcagaaggcg tcacaacaac ctggtcacag gactctgcct cctcttcaac      840

tgaccagcct ccatgctgcc tccagaatgg tctttctaat gtgtgaatca gagcacagca      900

gcccctgcac aaagcccttc catgtcgcct ctgcattcag gatcaaaccc cgaccacctg      960

cccaacctgc tctcctcttg ccactgcctc ttcctccctc attccacctt cccatgccct     1020

ggatccatca ggccacttga tgacccccaa ccaagtggct cccacaccct gttttacaaa     1080

aaagaaaaga ccagtccatg agggaggttt ttaagggttt gtggaaaatg aaaattagga     1140

tttcatgatt tttttttttc agtccccgtg aaggagagcc cttcatttgg agattatgtt     1200

ctttcgggga gaggctgagg acttaaaata ttcctgcatt tgtgaaatga tggtgaaagt     1260

aagtggtagc ttttcccttc tttttcttct ttttttgtga tgtcccaact tgtaaaaatt     1320

aaaagttatg gtactatgtt agccccataa tttttttttt ccttttaaaa cacttccata     1380

atctggactc ctctgtccag gcactgctgc ccagcctcca agctccatct ccactccaga     1440

ttttttacag ctgcctgcag tactttacct cctatcagaa gtttctcagc tcccaaggct     1500

ctgagcaaat gtggctcctg ggggttcttt cttcctctgc tgaaggaata aattgctcct     1560

tgacattgta gagcttctgg cacttggaga cttgtatgaa agatggctgt gcctctgcct     1620

gtctccccca ccgggctggg agctctgcag agcaggaaac atgactcgta tatgtctcag     1680

gtccctgcag ggccaagcac ctagcctcgc tcttggcagg tactcagcga atgaatgctg     1740

tatatgttgg gtgcaaagtt ccctacttcc tgtgacttca gctctgtttt acaataaaat     1800

cttgaaaatg cctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaa                                                                 1865


<210>  42
<211>  1802
<212>  DNA
<213>  Homo sapiens

<400>  42
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg       60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc      120

ctccccatgg ctttagagac gatctgccga ccctctggga gaaaatccag caagatgcaa      180

gccttcagaa tctgggatgt taaccagaag accttctatc tgaggaacaa ccaactagtt      240

gctggatact tgcaaggacc aaatgtcaat ttagaagaaa agatagatgt ggtacccatt      300

gagcctcatg ctctgttctt gggaatccat ggagggaaga tgtgcctgtc ctgtgtcaag      360

tctggtgatg agaccagact ccagctggag gcagttaaca tcactgacct gagcgagaac      420

agaaagcagg acaagcgctt cgccttcatc cgctcagaca gtggccccac caccagtttt      480

gagtctgccg cctgccccgg ttggttcctc tgcacagcga tggaagctga ccagcccgtc      540

agcctcacca atatgcctga cgaaggcgtc atggtcacca aattctactt ccaggaggac      600

gagtagtact gcccaggcct gcctgttccc attcttgcat ggcaaggact gcagggactg      660

ccagtccccc tgccccaggg ctcccggcta tgggggcact gaggaccagc cattgagggg      720

tggaccctca gaaggcgtca caacaacctg gtcacaggac tctgcctcct cttcaactga      780

ccagcctcca tgctgcctcc agaatggtct ttctaatgtg tgaatcagag cacagcagcc      840

cctgcacaaa gcccttccat gtcgcctctg cattcaggat caaaccccga ccacctgccc      900

aacctgctct cctcttgcca ctgcctcttc ctccctcatt ccaccttccc atgccctgga      960

tccatcaggc cacttgatga cccccaacca agtggctccc acaccctgtt ttacaaaaaa     1020

gaaaagacca gtccatgagg gaggttttta agggtttgtg gaaaatgaaa attaggattt     1080

catgattttt ttttttcagt ccccgtgaag gagagccctt catttggaga ttatgttctt     1140

tcggggagag gctgaggact taaaatattc ctgcatttgt gaaatgatgg tgaaagtaag     1200

tggtagcttt tcccttcttt ttcttctttt tttgtgatgt cccaacttgt aaaaattaaa     1260

agttatggta ctatgttagc cccataattt tttttttcct tttaaaacac ttccataatc     1320

tggactcctc tgtccaggca ctgctgccca gcctccaagc tccatctcca ctccagattt     1380

tttacagctg cctgcagtac tttacctcct atcagaagtt tctcagctcc caaggctctg     1440

agcaaatgtg gctcctgggg gttctttctt cctctgctga aggaataaat tgctccttga     1500

cattgtagag cttctggcac ttggagactt gtatgaaaga tggctgtgcc tctgcctgtc     1560

tcccccaccg ggctgggagc tctgcagagc aggaaacatg actcgtatat gtctcaggtc     1620

cctgcagggc caagcaccta gcctcgctct tggcaggtac tcagcgaatg aatgctgtat     1680

atgttgggtg caaagttccc tacttcctgt gacttcagct ctgttttaca ataaaatctt     1740

gaaaatgcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aa                                                                    1802


<210>  43
<211>  1973
<212>  DNA
<213>  Homo sapiens

<400>  43
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg       60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc      120

ctccccatgg ctttaggggg attataaaac taatcatcaa agccaagaag gcaagagcaa      180

gcatgtaccg ctgaaaacac aagataactg cataagtaat gactttcagt gcagattcat      240

agctaaccca taaactgctg gggcaaaaat catcttggaa ggctctgaac ctcagaaagg      300

attcacaaga cgatctgccg accctctggg agaaaatcca gcaagatgca agccttcaga      360

atctgggatg ttaaccagaa gaccttctat ctgaggaaca accaactagt tgctggatac      420

ttgcaaggac caaatgtcaa tttagaagaa aagatagatg tggtacccat tgagcctcat      480

gctctgttct tgggaatcca tggagggaag atgtgcctgt cctgtgtcaa gtctggtgat      540

gagaccagac tccagctgga ggcagttaac atcactgacc tgagcgagaa cagaaagcag      600

gacaagcgct tcgccttcat ccgctcagac agtggcccca ccaccagttt tgagtctgcc      660

gcctgccccg gttggttcct ctgcacagcg atggaagctg accagcccgt cagcctcacc      720

aatatgcctg acgaaggcgt catggtcacc aaattctact tccaggagga cgagtagtac      780

tgcccaggcc tgcctgttcc cattcttgca tggcaaggac tgcagggact gccagtcccc      840

ctgccccagg gctcccggct atgggggcac tgaggaccag ccattgaggg gtggaccctc      900

agaaggcgtc acaacaacct ggtcacagga ctctgcctcc tcttcaactg accagcctcc      960

atgctgcctc cagaatggtc tttctaatgt gtgaatcaga gcacagcagc ccctgcacaa     1020

agcccttcca tgtcgcctct gcattcagga tcaaaccccg accacctgcc caacctgctc     1080

tcctcttgcc actgcctctt cctccctcat tccaccttcc catgccctgg atccatcagg     1140

ccacttgatg acccccaacc aagtggctcc cacaccctgt tttacaaaaa agaaaagacc     1200

agtccatgag ggaggttttt aagggtttgt ggaaaatgaa aattaggatt tcatgatttt     1260

tttttttcag tccccgtgaa ggagagccct tcatttggag attatgttct ttcggggaga     1320

ggctgaggac ttaaaatatt cctgcatttg tgaaatgatg gtgaaagtaa gtggtagctt     1380

ttcccttctt tttcttcttt ttttgtgatg tcccaacttg taaaaattaa aagttatggt     1440

actatgttag ccccataatt ttttttttcc ttttaaaaca cttccataat ctggactcct     1500

ctgtccaggc actgctgccc agcctccaag ctccatctcc actccagatt ttttacagct     1560

gcctgcagta ctttacctcc tatcagaagt ttctcagctc ccaaggctct gagcaaatgt     1620

ggctcctggg ggttctttct tcctctgctg aaggaataaa ttgctccttg acattgtaga     1680

gcttctggca cttggagact tgtatgaaag atggctgtgc ctctgcctgt ctcccccacc     1740

gggctgggag ctctgcagag caggaaacat gactcgtata tgtctcaggt ccctgcaggg     1800

ccaagcacct agcctcgctc ttggcaggta ctcagcgaat gaatgctgta tatgttgggt     1860

gcaaagttcc ctacttcctg tgacttcagc tctgttttac aataaaatct tgaaaatgcc     1920

taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1973


<210>  44
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Lys Ala Leu Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln 
1               5                   10                  15      


Asp Ile Asn His Arg Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala 
            20                  25                  30          


Val Pro Arg Lys Asp Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser 
        35                  40                  45              


Cys Arg His Val Glu Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr 
    50                  55                  60                  


Leu Gly Leu Asn Gly Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly 
65                  70                  75                  80  


Asp Gln Pro Thr Leu Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr 
                85                  90                  95      


Asn Gln Pro Glu Pro Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser 
            100                 105                 110         


Gly Arg Asn Ser Thr Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile 
        115                 120                 125             


Ala Val Ser Ser Glu Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu 
    130                 135                 140                 


Gly Lys Ala Asn Thr Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150                 155             


<210>  45
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  45
atggaaaaag cattgaaaat tgacacacct cagcagggga gcattcagga tatcaatcat       60

cgggtgtggg ttcttcagga ccagacgctc atagcagtcc cgaggaagga ccgtatgtct      120

ccagtcacta ttgccttaat ctcatgccga catgtggaga cccttgagaa agacagaggg      180

aaccccatct acctgggcct gaatggactc aatctctgcc tgatgtgtgc taaagtcggg      240

gaccagccca cactgcagct gaaggaaaag gatataatgg atttgtacaa ccaacccgag      300

cctgtgaagt cctttctctt ctaccacagc cagagtggca ggaactccac cttcgagtct      360

gtggctttcc ctggctggtt catcgctgtc agctctgaag gaggctgtcc tctcatcctt      420

acccaagaac tggggaaagc caacactact gactttgggt taactatgct gttttaa         477


<210>  46
<211>  270
<212>  PRT
<213>  Mus musculus

<400>  46

Met Ala Lys Val Pro Asp Leu Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Asp Tyr Ser Ser Ala Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr Asp Ala Ser Tyr Gly Ser Leu His Glu Thr Cys Thr 
        35                  40                  45              


Asp Gln Phe Val Ser Leu Arg Thr Ser Glu Thr Ser Lys Met Ser Asn 
    50                  55                  60                  


Phe Thr Phe Lys Glu Ser Arg Val Thr Val Ser Ala Thr Ser Ser Asn 
65                  70                  75                  80  


Gly Lys Ile Leu Lys Lys Arg Arg Leu Ser Phe Ser Glu Thr Phe Thr 
                85                  90                  95      


Glu Asp Asp Leu Gln Ser Ile Thr His Asp Leu Glu Glu Thr Ile Gln 
            100                 105                 110         


Pro Arg Ser Ala Pro Tyr Thr Tyr Gln Ser Asp Leu Arg Tyr Lys Leu 
        115                 120                 125             


Met Lys Leu Val Arg Gln Lys Phe Val Met Asn Asp Ser Leu Asn Gln 
    130                 135                 140                 


Thr Ile Tyr Gln Asp Val Asp Lys His Tyr Leu Ser Thr Thr Trp Leu 
145                 150                 155                 160 


Asn Asp Leu Gln Gln Glu Val Lys Phe Asp Met Tyr Ala Tyr Ser Ser 
                165                 170                 175     


Gly Gly Asp Asp Ser Lys Tyr Pro Val Thr Leu Lys Ile Ser Asp Ser 
            180                 185                 190         


Gln Leu Phe Val Ser Ala Gln Gly Glu Asp Gln Pro Val Leu Leu Lys 
        195                 200                 205             


Glu Leu Pro Glu Thr Pro Lys Leu Ile Thr Gly Ser Glu Thr Asp Leu 
    210                 215                 220                 


Ile Phe Phe Trp Lys Ser Ile Asn Ser Lys Asn Tyr Phe Thr Ser Ala 
225                 230                 235                 240 


Ala Tyr Pro Glu Leu Phe Ile Ala Thr Lys Glu Gln Ser Arg Val His 
                245                 250                 255     


Leu Ala Arg Gly Leu Pro Ser Met Thr Asp Phe Gln Ile Ser 
            260                 265                 270 


<210>  47
<211>  1974
<212>  DNA
<213>  Mus musculus

<400>  47
aagtctccag ggcagagagg gagtcaactc attggcgctt gagtcggcaa agaaatcaag       60

atggccaaag ttcctgactt gtttgaagac ctaaagaact gttacagtga aaacgaagac      120

tacagttctg ccattgacca tctctctctg aatcagaaat ccttctatga tgcaagctat      180

ggctcacttc atgagacttg cacagatcag tttgtatctc tgagaacctc tgaaacgtca      240

aagatgtcca acttcacctt caaggagagc cgggtgacag tatcagcaac gtcaagcaac      300

gggaagattc tgaagaagag acggctgagt ttcagtgaga ccttcactga agatgacctg      360

cagtccataa cccatgatct ggaagagacc atccaaccca gatcagcacc ttacacctac      420

cagagtgatt tgagatacaa actgatgaag ctcgtcaggc agaagtttgt catgaatgat      480

tccctcaacc aaactatata tcaggatgtg gacaaacact atctcagcac cacttggtta      540

aatgacctgc aacaggaagt aaaatttgac atgtatgcct actcgtcggg aggagacgac      600

tctaaatatc ctgttactct aaaaatctca gattcacaac tgttcgtgag cgctcaagga      660

gaagaccagc ccgtgttgct gaaggagttg ccagaaacac caaaactcat cacaggtagt      720

gagaccgacc tcattttctt ctggaaaagt atcaactcta agaactactt cacatcagct      780

gcttatccag agctgtttat tgccaccaaa gaacaaagtc gggtgcacct ggcacgggga      840

ctgccctcta tgacagactt ccagatatca taaaagcagc cttatttcgg gagtctattc      900

acttgggaag tgctgacagt ctgtatgtac catgtacagg aaccttcctc accctgagtc      960

acttgcacag catgtgctga gtctctgtaa ttctaaatga atgtttaccc tctttgtaag     1020

agaagagcaa accctagtgg agccaccccg acatatgata ctatctgtta ttttaaagag     1080

taccctatag tttgctcagt actaatcatt ttaattacta ttctgcatgg cattcttagg     1140

aggatcaaaa agactctaca catattacag atgggttaac aaagggataa aacaactgaa     1200

aagcacactc aatgcatttg gaatataaat tcacagacca atctcactgt gcaccttcgg     1260

cttcaaaatg ccagttgagt aggataaagg tataagaact taatgctgtc attttcaaaa     1320

ggaaggggac aatagctaca tctttcctac ctcagtgggt tttactccag tgagatcatt     1380

tggatgaaat cctcctgtaa cagacctcaa gaaggagaca gactgttgaa tgttattttt     1440

aagttatttt atctatgtat ttataaatat atttatgata attatattat ttatggaaca     1500

tccttaaatc ctctgagctt gacggcaccc tcgcagcagg gttttctagg tggtcagtta     1560

gatgtagtct cctctagagc tccatgctac agacttttac actttttcca cagccacgaa     1620

gctctccgta cattcctgca cttgggagcc ctttcatcat gatcttaatc tgtgctgttt     1680

actttgtgca tctaaaatga taattgagtc agtctttctc cctcccgtcc ttaaagctgt     1740

ctgggtattc ttacatcatt cagtctcacc tgtaactaac accaaccatc taaagatgga     1800

aagagcttaa ctgtgacaac cacatcactg atacctgaag tttcttttct agaatgtaat     1860

cagtgtttcc cctggattcc aatttttttt tcaaaccaca gtgtcatgta actatcaaca     1920

ataacaatca actcattatt attaatcata attaaataaa acaggtttga gctg           1974


<210>  48
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  48

Met Ala Thr Val Pro Glu Leu Asn Cys Glu Met Pro Pro Phe Asp Ser 
1               5                   10                  15      


Asp Glu Asn Asp Leu Phe Phe Glu Val Asp Gly Pro Gln Lys Met Lys 
            20                  25                  30          


Gly Cys Phe Gln Thr Phe Asp Leu Gly Cys Pro Asp Glu Ser Ile Gln 
        35                  40                  45              


Leu Gln Ile Ser Gln Gln His Ile Asn Lys Ser Phe Arg Gln Ala Val 
    50                  55                  60                  


Ser Leu Ile Val Ala Val Glu Lys Leu Trp Gln Leu Pro Val Ser Phe 
65                  70                  75                  80  


Pro Trp Thr Phe Gln Asp Glu Asp Met Ser Thr Phe Phe Ser Phe Ile 
                85                  90                  95      


Phe Glu Glu Glu Pro Ile Leu Cys Asp Ser Trp Asp Asp Asp Asp Asn 
            100                 105                 110         


Leu Leu Val Cys Asp Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
        115                 120                 125             


Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
    130                 135                 140                 


Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
145                 150                 155                 160 


Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
                165                 170                 175     


Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
            180                 185                 190         


Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
        195                 200                 205             


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
    210                 215                 220                 


Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
225                 230                 235                 240 


Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
                245                 250                 255     


Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
            260                 265                 


<210>  49
<211>  1328
<212>  DNA
<213>  Mus musculus

<400>  49
cgaggcctaa taggctcatc tgggatcctc tccagccaag cttccttgtg caagtgtctg       60

aagcagctat ggcaactgtt cctgaactca actgtgaaat gccacctttt gacagtgatg      120

agaatgacct gttctttgaa gttgacggac cccaaaagat gaagggctgc ttccaaacct      180

ttgacctggg ctgtcctgat gagagcatcc agcttcaaat ctcgcagcag cacatcaaca      240

agagcttcag gcaggcagta tcactcattg tggctgtgga gaagctgtgg cagctacctg      300

tgtctttccc gtggaccttc caggatgagg acatgagcac cttcttttcc ttcatctttg      360

aagaagagcc catcctctgt gactcatggg atgatgatga taacctgctg gtgtgtgacg      420

ttcccattag acaactgcac tacaggctcc gagatgaaca acaaaaaagc ctcgtgctgt      480

cggacccata tgagctgaaa gctctccacc tcaatggaca gaatatcaac caacaagtga      540

tattctccat gagctttgta caaggagaac caagcaacga caaaatacct gtggccttgg      600

gcctcaaagg aaagaatcta tacctgtcct gtgtaatgaa agacggcaca cccaccctgc      660

agctggagag tgtggatccc aagcaatacc caaagaagaa gatggaaaaa cggtttgtct      720

tcaacaagat agaagtcaag agcaaagtgg agtttgagtc tgcagagttc cccaactggt      780

acatcagcac ctcacaagca gagcacaagc ctgtcttcct gggaaacaac agtggtcagg      840

acataattga cttcaccatg gaatccgtgt cttcctaaag tatgggctgg actgtttcta      900

atgccttccc cagggcatgt taaggagctc ccttttcgtg aatgagcaga cagctcaatc      960

tccaggggac tccttagtcc tcggccaaga caggtcgctc agggtcacaa gaaaccatgg     1020

cacattctgt tcaaagagag cctgtgtttt cctccttgcc tctgatgggc aaccacttac     1080

ctatttattt atgtatttat tgattggttg atctatttaa gttgattcaa ggggacatta     1140

ggcagcactc tctagaacag aacctagctg tcaacgtgtg ggggatgaat tggtcatagc     1200

ccgcactgag gtctttcatt gaagctgaga ataaataggt tcctataata tggatgagac     1260

tttttatgaa tgaagcacca gcacattgct ttgatgagta tgaaataaat ttcattaaaa     1320

caaacaaa                                                              1328


<210>  50
<211>  576
<212>  PRT
<213>  Mus musculus

<400>  50

Met Glu Asn Met Lys Val Leu Leu Gly Leu Ile Cys Leu Met Val Pro 
1               5                   10                  15      


Leu Leu Ser Leu Glu Ile Asp Val Cys Thr Glu Tyr Pro Asn Gln Ile 
            20                  25                  30          


Val Leu Phe Leu Ser Val Asn Glu Ile Asp Ile Arg Lys Cys Pro Leu 
        35                  40                  45              


Thr Pro Asn Lys Met His Gly Asp Thr Ile Ile Trp Tyr Lys Asn Asp 
    50                  55                  60                  


Ser Lys Thr Pro Ile Ser Ala Asp Arg Asp Ser Arg Ile His Gln Gln 
65                  70                  75                  80  


Asn Glu His Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly Tyr 
                85                  90                  95      


Tyr Tyr Cys Ile Val Arg Asn Ser Thr Tyr Cys Leu Lys Thr Lys Val 
            100                 105                 110         


Thr Val Thr Val Leu Glu Asn Asp Pro Gly Leu Cys Tyr Ser Thr Gln 
        115                 120                 125             


Ala Thr Phe Pro Gln Arg Leu His Ile Ala Gly Asp Gly Ser Leu Val 
    130                 135                 140                 


Cys Pro Tyr Val Ser Tyr Phe Lys Asp Glu Asn Asn Glu Leu Pro Glu 
145                 150                 155                 160 


Val Gln Trp Tyr Lys Asn Cys Lys Pro Leu Leu Leu Asp Asn Val Ser 
                165                 170                 175     


Phe Phe Gly Val Lys Asp Lys Leu Leu Val Arg Asn Val Ala Glu Glu 
            180                 185                 190         


His Arg Gly Asp Tyr Ile Cys Arg Met Ser Tyr Thr Phe Arg Gly Lys 
        195                 200                 205             


Gln Tyr Pro Val Thr Arg Val Ile Gln Phe Ile Thr Ile Asp Glu Asn 
    210                 215                 220                 


Lys Arg Asp Arg Pro Val Ile Leu Ser Pro Arg Asn Glu Thr Ile Glu 
225                 230                 235                 240 


Ala Asp Pro Gly Ser Met Ile Gln Leu Ile Cys Asn Val Thr Gly Gln 
                245                 250                 255     


Phe Ser Asp Leu Val Tyr Trp Lys Trp Asn Gly Ser Glu Ile Glu Trp 
            260                 265                 270         


Asn Asp Pro Phe Leu Ala Glu Asp Tyr Gln Phe Val Glu His Pro Ser 
        275                 280                 285             


Thr Lys Arg Lys Tyr Thr Leu Ile Thr Thr Leu Asn Ile Ser Glu Val 
    290                 295                 300                 


Lys Ser Gln Phe Tyr Arg Tyr Pro Phe Ile Cys Val Val Lys Asn Thr 
305                 310                 315                 320 


Asn Ile Phe Glu Ser Ala His Val Gln Leu Ile Tyr Pro Val Pro Asp 
                325                 330                 335     


Phe Lys Asn Tyr Leu Ile Gly Gly Phe Ile Ile Leu Thr Ala Thr Ile 
            340                 345                 350         


Val Cys Cys Val Cys Ile Tyr Lys Val Phe Lys Val Asp Ile Val Leu 
        355                 360                 365             


Trp Tyr Arg Asp Ser Cys Ser Gly Phe Leu Pro Ser Lys Ala Ser Asp 
    370                 375                 380                 


Gly Lys Thr Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Leu Gly Glu 
385                 390                 395                 400 


Gly Ser Phe Ser Asp Leu Asp Thr Phe Val Phe Lys Leu Leu Pro Glu 
                405                 410                 415     


Val Leu Glu Gly Gln Phe Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp 
            420                 425                 430         


Asp Tyr Val Gly Glu Asp Thr Ile Glu Val Thr Asn Glu Asn Val Lys 
        435                 440                 445             


Lys Ser Arg Arg Leu Ile Ile Ile Leu Val Arg Asp Met Gly Gly Phe 
    450                 455                 460                 


Ser Trp Leu Gly Gln Ser Ser Glu Glu Gln Ile Ala Ile Tyr Asn Ala 
465                 470                 475                 480 


Leu Ile Gln Glu Gly Ile Lys Ile Val Leu Leu Glu Leu Glu Lys Ile 
                485                 490                 495     


Gln Asp Tyr Glu Lys Met Pro Asp Ser Ile Gln Phe Ile Lys Gln Lys 
            500                 505                 510         


His Gly Val Ile Cys Trp Ser Gly Asp Phe Gln Glu Arg Pro Gln Ser 
        515                 520                 525             


Ala Lys Thr Arg Phe Trp Lys Asn Leu Arg Tyr Gln Met Pro Ala Gln 
    530                 535                 540                 


Arg Arg Ser Pro Leu Ser Lys His Arg Leu Leu Thr Leu Asp Pro Val 
545                 550                 555                 560 


Arg Asp Thr Lys Glu Lys Leu Pro Ala Ala Thr His Leu Pro Leu Gly 
                565                 570                 575     


<210>  51
<211>  4739
<212>  DNA
<213>  Mus musculus

<400>  51
tgggtcgtct gactagaagt gagctgtctg tcattcttgt gcacgccagc ccagtaatca       60

tttggaggca aagcaaactg taagtaatgc tgtcctgggc tgacttgagg aggcagtttt      120

cgttttaaca gccagtgttt atttgctcag caaacgttgt ctcggggaga aatgtcgctg      180

gatgtcatca gagttcccag tgccccgaac cgtgaacaac acaaatggag aatatgaaag      240

tgctactggg gctcatttgt ctcatggtgc ctctgctgtc gctggagatt gacgtatgta      300

cagaatatcc aaatcagatc gttttgtttt tatctgtaaa tgaaattgat attcgcaagt      360

gtcctcttac tccaaataaa atgcacggcg acaccataat ttggtacaag aatgacagca      420

agacccccat atcagcggac cgggactcca ggattcatca gcagaatgaa catctttggt      480

ttgtacctgc caaggtggag gactcaggat attactattg tatagtaaga aactcaactt      540

actgcctcaa aactaaagta accgtaactg tgttagagaa tgaccctggc ttgtgttaca      600

gcacacaggc caccttccca cagcggctcc acattgccgg ggatggaagt cttgtgtgcc      660

cttatgtgag ttattttaaa gatgaaaata atgagttacc cgaggtccag tggtataaga      720

actgtaaacc tctgcttctt gacaacgtga gcttcttcgg agtaaaagat aaactgttgg      780

tgaggaatgt ggctgaagag cacagagggg actatatatg ccgtatgtcc tatacgttcc      840

gggggaagca atatccggtc acacgagtaa tacaatttat cacaatagat gaaaacaaga      900

gggacagacc tgttatcctg agccctcgga atgagacgat cgaagctgac ccaggatcaa      960

tgatacaact gatctgcaac gtcacgggcc agttctcaga ccttgtctac tggaagtgga     1020

atggatcaga aattgaatgg aatgatccat ttctagctga agactatcaa tttgtggaac     1080

atccttcaac caaaagaaaa tacacactca ttacaacact taacatttca gaagttaaaa     1140

gccagtttta tcgctatccg tttatctgtg ttgttaagaa cacaaatatt tttgagtcgg     1200

cgcatgtgca gttaatatac ccagtccctg acttcaagaa ttacctcatc gggggcttta     1260

tcatcctcac ggctacaatt gtatgctgtg tgtgcatcta taaagtcttc aaggttgaca     1320

tagtgctttg gtacagggac tcctgctctg gttttcttcc ttcaaaagct tcagatggaa     1380

agacatacga tgcctatatt ctttatccca agaccctggg agaggggtcc ttctcagact     1440

tagatacttt tgtttttaaa ctgttgcctg aggtcttgga gggacagttt ggatacaagc     1500

tgttcattta tggaagggat gactatgttg gagaagatac catcgaggtt actaatgaaa     1560

atgtaaagaa aagcaggagg ctgattatca ttctagtgag agatatggga ggcttcagct     1620

ggctgggcca gtcatctgaa gagcaaatag ccatatacaa tgctctcatc caggaaggaa     1680

ttaaaatcgt cctgcttgag ttggagaaaa tccaagacta tgagaaaatg ccagattcta     1740

ttcagttcat taagcagaaa cacggagtca tttgctggtc aggagacttt caagaaagac     1800

cacagtctgc aaagaccagg ttctggaaaa acttaagata ccagatgcca gcccaacgga     1860

gatcaccatt gtctaaacac cgcttactaa ccctggatcc tgtgcgggac actaaggaga     1920

aactgccggc agcaacacac ttaccactcg gctagcatgg caaaagtggg caggccaaga     1980

acttcggaat atctcccatc ataagaggct gcagctgggc tgtgcctccc agtaaaacag     2040

tcacgaacca aacctgtgca gtcccttgtt ccagatcacc tggaactgga ttgggaagag     2100

aacaggactt ggtggccagg accgctcaga gagccatggt tgctcaggga tgctgctccg     2160

ggatgcttga ctaacagtcg aggcagtgaa ctgggtgtag aaagcgtcag gaaatggcca     2220

catgtgtgga tggtttaatt agattctgtg gagtctcaca gtgggattgt ggttgtctga     2280

ggacactttg gggggtcgct gtccaagaag tggctcccca aagtataagt gcgggtgagg     2340

tttactgata ccccacagtg gaaggcattt cttccagata ttttccagat accttggccg     2400

ccaaacttcg ttttcaaaca ctgtgtttta ttgtgtagac cttgaaaacc acggtttcag     2460

tgaagaagga ttctgtaggg ttcactcttc tgcagtcact ttagctttct gcagaagtct     2520

agattttaaa ttaactgtag aaggaagtca gacacccaca ggtttcttct aatcaagctt     2580

ccaccctgca atggctgtcg tgccatcttc cttctgtgtt ttactcggct cattgcttct     2640

ctggagacaa atgcaatgct tcctaccccc gtcctgtcac aggcagtctg aggactcacc     2700

ttcacacgtg agacttcgct cttaccccag cccccaccgc tggaggggtt tcaatccccc     2760

accctggggc tcttctgcgc agaagctgaa gtctacgctc ctcccaatct ttggtcccag     2820

tgccgctgtt cgccttcctg ctggttgatt gcagaaccac ctctgagacc tctgtacctg     2880

ctcttggaat gtctctgtct ttgccctgcc gcccacttcc cgtgcctatg atttgctcta     2940

gcatttctgc cacctgacaa ggagaggagc ttgctaaagt ttaaagttta tttcaacgct     3000

aagatcccaa ccttccgatc tctgcctact ctcagacttg gccagccctc ttgcctgtca     3060

tcccaaccct gctgcttctc tgtaaaaggt tgtttcttta ctagcagaaa tcagtctgca     3120

gggaggggta gtgcgtgtat ctcactgttt tccgtattgg gaacagatgg tatagatttg     3180

ccaaggcctt tattttaaag tgttcttgga aaatcgtatt taaatttgca attattctaa     3240

tttgatatag agagaaactg acctatttaa caaatggact ctcttaattc tactggaccc     3300

aggccttgaa ctttctggtt tctgtctctg tgctctgact ttttgatttc aggtctagcc     3360

ctgtgcactt acctcagtac tcagtactta ctcagtacta actcagtact cgtgggagga     3420

cacccgaccc gggtgttctt tgagaagcag ctgagtgagg catgttttga caggaggaac     3480

ccagttcttt tcactgttgg tatttatagc acctaccttc agatttttca gtatgatgtt     3540

tctattttcc aatactggtt ccctaacggt caacatttct tctcccaact aaaaatgtaa     3600

gaagaaaaaa aaattttttt ctttttctct tttttttttt ttttgtggta cagaagtttt     3660

ttgtttggtt atttgtttgt ttgattttaa ctagatgact gtcttcagaa taatcctcac     3720

agttctggaa gattgaaaaa ccaagttcac atgacaagaa caaacccggt tttaagggtt     3780

gaatgtaggg ggataccatt ctgtctttta gactttcaac atctgctatg gtggagcaca     3840

aatgttattt aaaagcatct tctcacctac atagaagtaa acaaaacaca caatttggga     3900

ttttgactct tcagttttga cctcacttct cctggatcca acctgacagg agatgactgg     3960

attgctgggg tagagaagga aaggctgtcc ccgacagcag ccagaagtct gtgggagtga     4020

ggtcattcct gacccgtgat gctttcaagg cttggttttt ctgataatta tttttgcctg     4080

tcatcccaaa aacgtattga catgcgtgta tattacctgt gagtgagagt tcttagaaac     4140

ttggccagag aggataaagg ggagagcagt gacagagaac cgccgatctt gtgacaccgg     4200

agtctgaggt ggaacagagc cagtgtcagg aaagcccctc agcaagaaag aagagtcatt     4260

gctggttccc aggggcagtc acagaggatg aaataccaca tcaaggcagt gggaacttcc     4320

tgcgacttct cctggtcctc cccagaagta tctggtgtca gctgaagacc atgtgtcccc     4380

caatacttag atttcaccgt actttctgat ggtgttttta aaaggccaag tgttgcaaaa     4440

gtttgcacgt gcaaccgtat attaatcgcc agtgtttaaa actggtttat cagaatttat     4500

atttttgtct ctcctgcctt ttgaatttta cttatgacag agaaagtatt gagccatgac     4560

tttttaaaaa taatttatat ttatactggt caataatgaa ggtttttttt tattattaaa     4620

gaacttgatt ttataattct gcagcagatg ccaaatgtta tctatcacaa accacaaaat     4680

ttatgtacag tgcatattat tgatcaataa actaaacttg ttttccaata aattgttaa      4739


<210>  52
<211>  4808
<212>  DNA
<213>  Mus musculus

<400>  52
agtctccgcc cgctgcacgc ccccgcgggc ggctcagagt gggagcagcg tgctgctcag       60

aaggtcttag ctggtgcggg gttccaggag ccgcctggga gcgcggcgcc cacctagaag      120

ggcgggagcc cagctggtgc ccgcctgccc cagagcggaa ggaatgtgac ccccgagcga      180

gcgcggagca gcccttgagc ggctcccagg gctccggttg ctcccggcct gaacgggttt      240

agttcggagc tgctggattg ttgaacatcg ccactggggc acccgggcac gcccaggaga      300

atatgaaagt gctactgggg ctcatttgtc tcatggtgcc tctgctgtcg ctggagattg      360

acgtatgtac agaatatcca aatcagatcg ttttgttttt atctgtaaat gaaattgata      420

ttcgcaagtg tcctcttact ccaaataaaa tgcacggcga caccataatt tggtacaaga      480

atgacagcaa gacccccata tcagcggacc gggactccag gattcatcag cagaatgaac      540

atctttggtt tgtacctgcc aaggtggagg actcaggata ttactattgt atagtaagaa      600

actcaactta ctgcctcaaa actaaagtaa ccgtaactgt gttagagaat gaccctggct      660

tgtgttacag cacacaggcc accttcccac agcggctcca cattgccggg gatggaagtc      720

ttgtgtgccc ttatgtgagt tattttaaag atgaaaataa tgagttaccc gaggtccagt      780

ggtataagaa ctgtaaacct ctgcttcttg acaacgtgag cttcttcgga gtaaaagata      840

aactgttggt gaggaatgtg gctgaagagc acagagggga ctatatatgc cgtatgtcct      900

atacgttccg ggggaagcaa tatccggtca cacgagtaat acaatttatc acaatagatg      960

aaaacaagag ggacagacct gttatcctga gccctcggaa tgagacgatc gaagctgacc     1020

caggatcaat gatacaactg atctgcaacg tcacgggcca gttctcagac cttgtctact     1080

ggaagtggaa tggatcagaa attgaatgga atgatccatt tctagctgaa gactatcaat     1140

ttgtggaaca tccttcaacc aaaagaaaat acacactcat tacaacactt aacatttcag     1200

aagttaaaag ccagttttat cgctatccgt ttatctgtgt tgttaagaac acaaatattt     1260

ttgagtcggc gcatgtgcag ttaatatacc cagtccctga cttcaagaat tacctcatcg     1320

ggggctttat catcctcacg gctacaattg tatgctgtgt gtgcatctat aaagtcttca     1380

aggttgacat agtgctttgg tacagggact cctgctctgg ttttcttcct tcaaaagctt     1440

cagatggaaa gacatacgat gcctatattc tttatcccaa gaccctggga gaggggtcct     1500

tctcagactt agatactttt gtttttaaac tgttgcctga ggtcttggag ggacagtttg     1560

gatacaagct gttcatttat ggaagggatg actatgttgg agaagatacc atcgaggtta     1620

ctaatgaaaa tgtaaagaaa agcaggaggc tgattatcat tctagtgaga gatatgggag     1680

gcttcagctg gctgggccag tcatctgaag agcaaatagc catatacaat gctctcatcc     1740

aggaaggaat taaaatcgtc ctgcttgagt tggagaaaat ccaagactat gagaaaatgc     1800

cagattctat tcagttcatt aagcagaaac acggagtcat ttgctggtca ggagactttc     1860

aagaaagacc acagtctgca aagaccaggt tctggaaaaa cttaagatac cagatgccag     1920

cccaacggag atcaccattg tctaaacacc gcttactaac cctggatcct gtgcgggaca     1980

ctaaggagaa actgccggca gcaacacact taccactcgg ctagcatggc aaaagtgggc     2040

aggccaagaa cttcggaata tctcccatca taagaggctg cagctgggct gtgcctccca     2100

gtaaaacagt cacgaaccaa acctgtgcag tcccttgttc cagatcacct ggaactggat     2160

tgggaagaga acaggacttg gtggccagga ccgctcagag agccatggtt gctcagggat     2220

gctgctccgg gatgcttgac taacagtcga ggcagtgaac tgggtgtaga aagcgtcagg     2280

aaatggccac atgtgtggat ggtttaatta gattctgtgg agtctcacag tgggattgtg     2340

gttgtctgag gacactttgg ggggtcgctg tccaagaagt ggctccccaa agtataagtg     2400

cgggtgaggt ttactgatac cccacagtgg aaggcatttc ttccagatat tttccagata     2460

ccttggccgc caaacttcgt tttcaaacac tgtgttttat tgtgtagacc ttgaaaacca     2520

cggtttcagt gaagaaggat tctgtagggt tcactcttct gcagtcactt tagctttctg     2580

cagaagtcta gattttaaat taactgtaga aggaagtcag acacccacag gtttcttcta     2640

atcaagcttc caccctgcaa tggctgtcgt gccatcttcc ttctgtgttt tactcggctc     2700

attgcttctc tggagacaaa tgcaatgctt cctacccccg tcctgtcaca ggcagtctga     2760

ggactcacct tcacacgtga gacttcgctc ttaccccagc ccccaccgct ggaggggttt     2820

caatccccca ccctggggct cttctgcgca gaagctgaag tctacgctcc tcccaatctt     2880

tggtcccagt gccgctgttc gccttcctgc tggttgattg cagaaccacc tctgagacct     2940

ctgtacctgc tcttggaatg tctctgtctt tgccctgccg cccacttccc gtgcctatga     3000

tttgctctag catttctgcc acctgacaag gagaggagct tgctaaagtt taaagtttat     3060

ttcaacgcta agatcccaac cttccgatct ctgcctactc tcagacttgg ccagccctct     3120

tgcctgtcat cccaaccctg ctgcttctct gtaaaaggtt gtttctttac tagcagaaat     3180

cagtctgcag ggaggggtag tgcgtgtatc tcactgtttt ccgtattggg aacagatggt     3240

atagatttgc caaggccttt attttaaagt gttcttggaa aatcgtattt aaatttgcaa     3300

ttattctaat ttgatataga gagaaactga cctatttaac aaatggactc tcttaattct     3360

actggaccca ggccttgaac tttctggttt ctgtctctgt gctctgactt tttgatttca     3420

ggtctagccc tgtgcactta cctcagtact cagtacttac tcagtactaa ctcagtactc     3480

gtgggaggac acccgacccg ggtgttcttt gagaagcagc tgagtgaggc atgttttgac     3540

aggaggaacc cagttctttt cactgttggt atttatagca cctaccttca gatttttcag     3600

tatgatgttt ctattttcca atactggttc cctaacggtc aacatttctt ctcccaacta     3660

aaaatgtaag aagaaaaaaa aatttttttc tttttctctt tttttttttt tttgtggtac     3720

agaagttttt tgtttggtta tttgtttgtt tgattttaac tagatgactg tcttcagaat     3780

aatcctcaca gttctggaag attgaaaaac caagttcaca tgacaagaac aaacccggtt     3840

ttaagggttg aatgtagggg gataccattc tgtcttttag actttcaaca tctgctatgg     3900

tggagcacaa atgttattta aaagcatctt ctcacctaca tagaagtaaa caaaacacac     3960

aatttgggat tttgactctt cagttttgac ctcacttctc ctggatccaa cctgacagga     4020

gatgactgga ttgctggggt agagaaggaa aggctgtccc cgacagcagc cagaagtctg     4080

tgggagtgag gtcattcctg acccgtgatg ctttcaaggc ttggtttttc tgataattat     4140

ttttgcctgt catcccaaaa acgtattgac atgcgtgtat attacctgtg agtgagagtt     4200

cttagaaact tggccagaga ggataaaggg gagagcagtg acagagaacc gccgatcttg     4260

tgacaccgga gtctgaggtg gaacagagcc agtgtcagga aagcccctca gcaagaaaga     4320

agagtcattg ctggttccca ggggcagtca cagaggatga aataccacat caaggcagtg     4380

ggaacttcct gcgacttctc ctggtcctcc ccagaagtat ctggtgtcag ctgaagacca     4440

tgtgtccccc aatacttaga tttcaccgta ctttctgatg gtgtttttaa aaggccaagt     4500

gttgcaaaag tttgcacgtg caaccgtata ttaatcgcca gtgtttaaaa ctggtttatc     4560

agaatttata tttttgtctc tcctgccttt tgaattttac ttatgacaga gaaagtattg     4620

agccatgact ttttaaaaat aatttatatt tatactggtc aataatgaag gttttttttt     4680

attattaaag aacttgattt tataattctg cagcagatgc caaatgttat ctatcacaaa     4740

ccacaaaatt tatgtacagt gcatattatt gatcaataaa ctaaacttgt tttccaataa     4800

attgttaa                                                              4808


<210>  53
<211>  410
<212>  PRT
<213>  Mus musculus

<400>  53

Met Phe Ile Leu Leu Val Leu Val Thr Gly Val Ser Ala Phe Thr Thr 
1               5                   10                  15      


Pro Thr Val Val His Thr Gly Lys Val Ser Glu Ser Pro Ile Thr Ser 
            20                  25                  30          


Glu Lys Pro Thr Val His Gly Asp Asn Cys Gln Phe Arg Gly Arg Glu 
        35                  40                  45              


Phe Lys Ser Glu Leu Arg Leu Glu Gly Glu Pro Val Val Leu Arg Cys 
    50                  55                  60                  


Pro Leu Ala Pro His Ser Asp Ile Ser Ser Ser Ser His Ser Phe Leu 
65                  70                  75                  80  


Thr Trp Ser Lys Leu Asp Ser Ser Gln Leu Ile Pro Arg Asp Glu Pro 
                85                  90                  95      


Arg Met Trp Val Lys Gly Asn Ile Leu Trp Ile Leu Pro Ala Val Gln 
            100                 105                 110         


Gln Asp Ser Gly Thr Tyr Ile Cys Thr Phe Arg Asn Ala Ser His Cys 
        115                 120                 125             


Glu Gln Met Ser Val Glu Leu Lys Val Phe Lys Asn Thr Glu Ala Ser 
    130                 135                 140                 


Leu Pro His Val Ser Tyr Leu Gln Ile Ser Ala Leu Ser Thr Thr Gly 
145                 150                 155                 160 


Leu Leu Val Cys Pro Asp Leu Lys Glu Phe Ile Ser Ser Asn Ala Asp 
                165                 170                 175     


Gly Lys Ile Gln Trp Tyr Lys Gly Ala Ile Leu Leu Asp Lys Gly Asn 
            180                 185                 190         


Lys Glu Phe Leu Ser Ala Gly Asp Pro Thr Arg Leu Leu Ile Ser Asn 
        195                 200                 205             


Thr Ser Met Asp Asp Ala Gly Tyr Tyr Arg Cys Val Met Thr Phe Thr 
    210                 215                 220                 


Tyr Asn Gly Gln Glu Tyr Asn Ile Thr Arg Asn Ile Glu Leu Arg Val 
225                 230                 235                 240 


Lys Gly Thr Thr Thr Glu Pro Ile Pro Val Ile Ile Ser Pro Leu Glu 
                245                 250                 255     


Thr Ile Pro Ala Ser Leu Gly Ser Arg Leu Ile Val Pro Cys Lys Val 
            260                 265                 270         


Phe Leu Gly Thr Gly Thr Ser Ser Asn Thr Ile Val Trp Trp Leu Ala 
        275                 280                 285             


Asn Ser Thr Phe Ile Ser Ala Ala Tyr Pro Arg Gly Arg Val Thr Glu 
    290                 295                 300                 


Gly Leu His His Gln Tyr Ser Glu Asn Asp Glu Asn Tyr Val Glu Val 
305                 310                 315                 320 


Ser Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu His Thr Asp Phe 
                325                 330                 335     


Lys Cys Val Ala Ser Asn Pro Arg Ser Ser Gln Ser Leu His Thr Thr 
            340                 345                 350         


Val Lys Glu Val Ser Ser Thr Phe Ser Trp Ser Ile Ala Leu Ala Pro 
        355                 360                 365             


Leu Ser Leu Ile Ile Leu Val Val Gly Ala Ile Trp Met Arg Arg Arg 
    370                 375                 380                 


Cys Lys Arg Arg Ala Gly Lys Thr Tyr Gly Leu Thr Lys Leu Arg Thr 
385                 390                 395                 400 


Asp Asn Gln Asp Phe Pro Ser Ser Pro Asn 
                405                 410 


<210>  54
<211>  1360
<212>  DNA
<213>  Mus musculus

<400>  54
gccttcccca gtcaggcaag aagcagcaag gtacaagaat acacagctcc aggctccaag       60

ggtcctgtgc gctcaggaag ttggtgcgga caatgttcat cttgcttgtg ttagtaactg      120

gagtttctgc tttcaccact ccaacagtgg tgcacacagg aaaggtttct gaatccccca      180

ttacatcgga gaagcccaca gtccatggag acaactgtca gtttcgtggc agagagttca      240

aatctgaatt gaggctggaa ggtgaacctg tggttctgag gtgccccttg gcacctcact      300

ccgacatctc cagcagttcc catagttttc tgacctggag taaattggac tcttctcagc      360

tgatcccaag agatgagcca aggatgtggg tgaagggtaa catactctgg attctgccag      420

cagtgcagca agactctggt acctacattt gcacattcag aaacgcatcc cactgtgagc      480

aaatgtctgt ggaactcaag gtctttaaga atactgaagc atctctgcct catgtctcct      540

acttgcaaat ctcagctctc tccaccaccg ggttactagt gtgccctgac ctgaaagaat      600

tcatctccag caacgctgat ggaaagatac agtggtataa gggcgccata ctcttggata      660

aaggcaataa ggaatttctg agtgcaggag accccacacg cctattgata tccaacacgt      720

ccatggacga tgcaggctat tacagatgtg ttatgacatt tacctacaat ggccaggaat      780

acaacatcac taggaatatt gaactccggg tcaaaggaac aaccacggaa cccatccctg      840

tgatcatttc tcccctggag acaataccag catcattggg gtcaagactg atagtcccgt      900

gcaaagtgtt tctgggaact ggtacatctt ccaacaccat tgtgtggtgg ttggctaaca      960

gcacgtttat ctcggctgct tacccaagag gccgtgtgac cgaggggcta caccaccagt     1020

actcagagaa tgatgaaaac tatgtggaag tgtcgctgat ttttgatcca gtcacaaggg     1080

aggatctgca tacagatttt aaatgtgttg cctcgaatcc acggagttct cagtcactcc     1140

ataccacagt caaagaagtc tcttccacgt tctcctggag cattgcgctg gcacctctgt     1200

ctctgatcat cttggttgtg ggggcaatat ggatgcgcag acggtgtaaa cgcagggctg     1260

gaaagacata tggactgacc aagctacgga ctgacaacca ggacttccct tccagcccaa     1320

actaaataaa ggaaatgaaa taaaaaaaaa aaaaaaaaaa                           1360


<210>  55
<211>  178
<212>  PRT
<213>  Mus musculus

<400>  55

Met Glu Ile Cys Trp Gly Pro Tyr Ser His Leu Ile Ser Leu Leu Leu 
1               5                   10                  15      


Ile Leu Leu Phe His Ser Glu Ala Ala Cys Arg Pro Ser Gly Lys Arg 
            20                  25                  30          


Pro Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Thr Asn Gln Lys Thr 
        35                  40                  45              


Phe Tyr Leu Arg Asn Asn Gln Leu Ile Ala Gly Tyr Leu Gln Gly Pro 
    50                  55                  60                  


Asn Ile Lys Leu Glu Glu Lys Ile Asp Met Val Pro Ile Asp Leu His 
65                  70                  75                  80  


Ser Val Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ser Cys Ala 
                85                  90                  95      


Lys Ser Gly Asp Asp Ile Lys Leu Gln Leu Glu Glu Val Asn Ile Thr 
            100                 105                 110         


Asp Leu Ser Lys Asn Lys Glu Glu Asp Lys Arg Phe Thr Phe Ile Arg 
        115                 120                 125             


Ser Glu Lys Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 
    130                 135                 140                 


Trp Phe Leu Cys Thr Thr Leu Glu Ala Asp Arg Pro Val Ser Leu Thr 
145                 150                 155                 160 


Asn Thr Pro Glu Glu Pro Leu Ile Val Thr Lys Phe Tyr Phe Gln Glu 
                165                 170                 175     


Asp Gln 
        


<210>  56
<211>  159
<212>  PRT
<213>  Mus musculus

<400>  56

Met Ala Ser Glu Ala Ala Cys Arg Pro Ser Gly Lys Arg Pro Cys Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Thr Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Ile Ala Gly Tyr Leu Gln Gly Pro Asn Ile Lys 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Met Val Pro Ile Asp Leu His Ser Val Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ser Cys Ala Lys Ser Gly 
65                  70                  75                  80  


Asp Asp Ile Lys Leu Gln Leu Glu Glu Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Lys Asn Lys Glu Glu Asp Lys Arg Phe Thr Phe Ile Arg Ser Glu Lys 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Thr Leu Glu Ala Asp Arg Pro Val Ser Leu Thr Asn Thr Pro 
    130                 135                 140                 


Glu Glu Pro Leu Ile Val Thr Lys Phe Tyr Phe Gln Glu Asp Gln 
145                 150                 155                 


<210>  57
<211>  178
<212>  PRT
<213>  Mus musculus

<400>  57

Met Glu Ile Cys Trp Gly Pro Tyr Ser His Leu Ile Ser Leu Leu Leu 
1               5                   10                  15      


Ile Leu Leu Phe His Ser Glu Ala Ala Cys Arg Pro Ser Gly Lys Arg 
            20                  25                  30          


Pro Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Thr Asn Gln Lys Thr 
        35                  40                  45              


Phe Tyr Leu Arg Asn Asn Gln Leu Ile Ala Gly Tyr Leu Gln Gly Pro 
    50                  55                  60                  


Asn Ile Lys Leu Glu Glu Lys Ile Asp Met Val Pro Ile Asp Leu His 
65                  70                  75                  80  


Ser Val Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ser Cys Ala 
                85                  90                  95      


Lys Ser Gly Asp Asp Ile Lys Leu Gln Leu Glu Glu Val Asn Ile Thr 
            100                 105                 110         


Asp Leu Ser Lys Asn Lys Glu Glu Asp Lys Arg Phe Thr Phe Ile Arg 
        115                 120                 125             


Ser Glu Lys Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 
    130                 135                 140                 


Trp Phe Leu Cys Thr Thr Leu Glu Ala Asp Arg Pro Val Ser Leu Thr 
145                 150                 155                 160 


Asn Thr Pro Glu Glu Pro Leu Ile Val Thr Lys Phe Tyr Phe Gln Glu 
                165                 170                 175     


Asp Gln 
        


<210>  58
<211>  162
<212>  PRT
<213>  Mus musculus

<400>  58

Met Thr Ala Ala Gln Ala Glu Ala Ala Cys Arg Pro Ser Gly Lys Arg 
1               5                   10                  15      


Pro Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Thr Asn Gln Lys Thr 
            20                  25                  30          


Phe Tyr Leu Arg Asn Asn Gln Leu Ile Ala Gly Tyr Leu Gln Gly Pro 
        35                  40                  45              


Asn Ile Lys Leu Glu Glu Lys Ile Asp Met Val Pro Ile Asp Leu His 
    50                  55                  60                  


Ser Val Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ser Cys Ala 
65                  70                  75                  80  


Lys Ser Gly Asp Asp Ile Lys Leu Gln Leu Glu Glu Val Asn Ile Thr 
                85                  90                  95      


Asp Leu Ser Lys Asn Lys Glu Glu Asp Lys Arg Phe Thr Phe Ile Arg 
            100                 105                 110         


Ser Glu Lys Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 
        115                 120                 125             


Trp Phe Leu Cys Thr Thr Leu Glu Ala Asp Arg Pro Val Ser Leu Thr 
    130                 135                 140                 


Asn Thr Pro Glu Glu Pro Leu Ile Val Thr Lys Phe Tyr Phe Gln Glu 
145                 150                 155                 160 


Asp Gln 
        


<210>  59
<211>  2464
<212>  DNA
<213>  Mus musculus

<400>  59
agttccaccc tgggaaggtc tgtgccatag acactgcctg ggtgctcctt tatacacagc       60

aagtctctct ggagtgagac gttggaaggc agtggaagac cttgtgtcct gtttagctca      120

cccatggctt cagaggcagc ctgccgccct tctgggaaaa gaccctgcaa gatgcaagcc      180

ttcagaatct gggatactaa ccagaagacc ttttacctga gaaacaacca gctcattgct      240

gggtacttac aaggaccaaa tatcaaacta gaagaaaaga tagacatggt gcctattgac      300

cttcatagtg tgttcttggg catccacggg ggcaagctgt gcctgtcttg tgccaagtct      360

ggagatgata tcaagctcca gctggaggaa gttaacatca ctgatctgag caagaacaaa      420

gaagaagaca agcgctttac cttcatccgc tctgagaaag gccccaccac cagctttgag      480

tcagctgcct gtccaggatg gttcctctgc acaacactag aggctgaccg tcctgtgagc      540

ctcaccaaca caccggaaga gccccttata gtcacgaagt tctacttcca ggaagaccaa      600

tagtactgcc gaggcctgta ataatcacca actgcctgat cactctggcc atcattgggg      660

cctgaggaac aacttttgca gggtgtatgt acagtagaag gagacagaag agttctgatg      720

atagatctct gcctcagtct gttggctggc ctaatcccca tgatgattcc agaataatct      780

tgcaaattgg atcatggcag gtgcttgttc aaagcccttt cttgttgcct ctgccatctg      840

ggtgaagtct agaccacttg cttggcctag gtgtcttctg ctctaccacc caccctaccc      900

ctgccacaaa cacacacttt ttttgttttt gttttttcca ttgttctgca cttccacagt      960

ccagaccaat caagtcactt gacaatatgc cccaagtgac tcccttaccc tgttttataa     1020

acctgtgcct gtctatggag aaggttttaa ttctccttgt tattcatttt gggctttttg     1080

atgaaaccac cagggcatca catatactaa gcatgtgctc taccatcatg ctatgcttcc     1140

agctcagggg ggcactttta aggatctaga aaacagaaat taaggatctc atagttattt     1200

tattaggcca gccttattcc atgtcggcaa gaggtttctt gtggaaatta tgtcctttct     1260

gagaggagct ggggattaga tgctcctgca tttgtgaaat ggttataagc atagaaaaat     1320

aggtggtaag ctttccttct ttccttattt tgtgtgatgc cttaaactga aaagttaaaa     1380

attgatggat tgtagcattc ccataatctc ccccttcttt ttttttcctt tggaaatgtc     1440

caatagtcta tattcctctg tcccgcccaa acaccatctt cactccaagc ctaccacaga     1500

tgcctgaaga agttcctcac tatctgcaaa tgtggctctc aggcccttcc tgatgtgatg     1560

aatgaatcta ctaatcattt cttgaccatt cattttatca cttctaacct tgaaacatgt     1620

ggaagtagct atgttcctga ctgtttcctc tgccagacaa tgaactctgg agatcaggga     1680

gcttcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgcg tgcgcgcgcg     1740

cgtgcgcacg cacgtgcatg cacatgctat gtattgggtc cctccaagga tgaaccctct     1800

ctttggctta gaaggcactc agagaatatg tgttattcgt gctcacggaa agtttcttac     1860

tcatccctgt gactttggct ttattttaca ataaaacact gaaaatgtcc actttgttag     1920

ttgtgaacat gagcccaggc ctaaggtgct gggaaacaga aagggcggga gatttttctt     1980

tattctatgg ctagaaaata gttacctcct ctctgaaagt cttcttcctc atttctgggt     2040

aacagaatat caaacacctt gcttataagt tataaagtag tgttgtccac catgaaccca     2100

ccaagtaaaa acaacccaaa tacctatcat ggatgaataa tcatgcaagt atcagatctg     2160

cactcaatgc cacacaatga caaagatagc aaatgagcca cagacggctc cacccaaccc     2220

aatagatgaa cacttggttc aaaatcacta aagctcaaat actcccaggt caaacaccag     2280

gtaacaagtt aatactcaac aaagggggaa aacaaatgtt ccactgaatc ctgtgaccct     2340

gtgggcgtgg ttcacctcct gtgttgtttg ccatgtgtgc tcaggatgag ctgattaaag     2400

ctcttctcag gggttcagtt ttcccatctc tgcttgtaaa taaaaagctt atgcagaata     2460

ctga                                                                  2464


<210>  60
<211>  2480
<212>  DNA
<213>  Mus musculus

<400>  60
gaatgactac tttctttata agcaaccacc ttgagcctga aatggcagtc gctagtctct       60

attgccttgc tgtggcctcg ggatggaaat ctgctgggga ccctacagtc acctaatctc      120

tctccttctc atccttctgt ttcattcaga ggcagcctgc cgcccttctg ggaaaagacc      180

ctgcaagatg caagccttca gaatctggga tactaaccag aagacctttt acctgagaaa      240

caaccagctc attgctgggt acttacaagg accaaatatc aaactagaag aaaagataga      300

catggtgcct attgaccttc atagtgtgtt cttgggcatc cacgggggca agctgtgcct      360

gtcttgtgcc aagtctggag atgatatcaa gctccagctg gaggaagtta acatcactga      420

tctgagcaag aacaaagaag aagacaagcg ctttaccttc atccgctctg agaaaggccc      480

caccaccagc tttgagtcag ctgcctgtcc aggatggttc ctctgcacaa cactagaggc      540

tgaccgtcct gtgagcctca ccaacacacc ggaagagccc cttatagtca cgaagttcta      600

cttccaggaa gaccaatagt actgccgagg cctgtaataa tcaccaactg cctgatcact      660

ctggccatca ttggggcctg aggaacaact tttgcagggt gtatgtacag tagaaggaga      720

cagaagagtt ctgatgatag atctctgcct cagtctgttg gctggcctaa tccccatgat      780

gattccagaa taatcttgca aattggatca tggcaggtgc ttgttcaaag ccctttcttg      840

ttgcctctgc catctgggtg aagtctagac cacttgcttg gcctaggtgt cttctgctct      900

accacccacc ctacccctgc cacaaacaca cacttttttt gtttttgttt tttccattgt      960

tctgcacttc cacagtccag accaatcaag tcacttgaca atatgcccca agtgactccc     1020

ttaccctgtt ttataaacct gtgcctgtct atggagaagg ttttaattct ccttgttatt     1080

cattttgggc tttttgatga aaccaccagg gcatcacata tactaagcat gtgctctacc     1140

atcatgctat gcttccagct caggggggca cttttaagga tctagaaaac agaaattaag     1200

gatctcatag ttattttatt aggccagcct tattccatgt cggcaagagg tttcttgtgg     1260

aaattatgtc ctttctgaga ggagctgggg attagatgct cctgcatttg tgaaatggtt     1320

ataagcatag aaaaataggt ggtaagcttt ccttctttcc ttattttgtg tgatgcctta     1380

aactgaaaag ttaaaaattg atggattgta gcattcccat aatctccccc ttcttttttt     1440

ttcctttgga aatgtccaat agtctatatt cctctgtccc gcccaaacac catcttcact     1500

ccaagcctac cacagatgcc tgaagaagtt cctcactatc tgcaaatgtg gctctcaggc     1560

ccttcctgat gtgatgaatg aatctactaa tcatttcttg accattcatt ttatcacttc     1620

taaccttgaa acatgtggaa gtagctatgt tcctgactgt ttcctctgcc agacaatgaa     1680

ctctggagat cagggagctt cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     1740

tgtgcgtgcg cgcgcgcgtg cgcacgcacg tgcatgcaca tgctatgtat tgggtccctc     1800

caaggatgaa ccctctcttt ggcttagaag gcactcagag aatatgtgtt attcgtgctc     1860

acggaaagtt tcttactcat ccctgtgact ttggctttat tttacaataa aacactgaaa     1920

atgtccactt tgttagttgt gaacatgagc ccaggcctaa ggtgctggga aacagaaagg     1980

gcgggagatt tttctttatt ctatggctag aaaatagtta cctcctctct gaaagtcttc     2040

ttcctcattt ctgggtaaca gaatatcaaa caccttgctt ataagttata aagtagtgtt     2100

gtccaccatg aacccaccaa gtaaaaacaa cccaaatacc tatcatggat gaataatcat     2160

gcaagtatca gatctgcact caatgccaca caatgacaaa gatagcaaat gagccacaga     2220

cggctccacc caacccaata gatgaacact tggttcaaaa tcactaaagc tcaaatactc     2280

ccaggtcaaa caccaggtaa caagttaata ctcaacaaag ggggaaaaca aatgttccac     2340

tgaatcctgt gaccctgtgg gcgtggttca cctcctgtgt tgtttgccat gtgtgctcag     2400

gatgagctga ttaaagctct tctcaggggt tcagttttcc catctctgct tgtaaataaa     2460

aagcttatgc agaatactga                                                 2480


<210>  61
<211>  2409
<212>  DNA
<213>  Mus musculus

<400>  61
agtaaaggtt tctctttttg gaaatatgag ggtttttccg cttctgacag tggaacggaa       60

tgacagcagc acaggctgag gcagcctgcc gcccttctgg gaaaagaccc tgcaagatgc      120

aagccttcag aatctgggat actaaccaga agacctttta cctgagaaac aaccagctca      180

ttgctgggta cttacaagga ccaaatatca aactagaaga aaagatagac atggtgccta      240

ttgaccttca tagtgtgttc ttgggcatcc acgggggcaa gctgtgcctg tcttgtgcca      300

agtctggaga tgatatcaag ctccagctgg aggaagttaa catcactgat ctgagcaaga      360

acaaagaaga agacaagcgc tttaccttca tccgctctga gaaaggcccc accaccagct      420

ttgagtcagc tgcctgtcca ggatggttcc tctgcacaac actagaggct gaccgtcctg      480

tgagcctcac caacacaccg gaagagcccc ttatagtcac gaagttctac ttccaggaag      540

accaatagta ctgccgaggc ctgtaataat caccaactgc ctgatcactc tggccatcat      600

tggggcctga ggaacaactt ttgcagggtg tatgtacagt agaaggagac agaagagttc      660

tgatgataga tctctgcctc agtctgttgg ctggcctaat ccccatgatg attccagaat      720

aatcttgcaa attggatcat ggcaggtgct tgttcaaagc cctttcttgt tgcctctgcc      780

atctgggtga agtctagacc acttgcttgg cctaggtgtc ttctgctcta ccacccaccc      840

tacccctgcc acaaacacac actttttttg tttttgtttt ttccattgtt ctgcacttcc      900

acagtccaga ccaatcaagt cacttgacaa tatgccccaa gtgactccct taccctgttt      960

tataaacctg tgcctgtcta tggagaaggt tttaattctc cttgttattc attttgggct     1020

ttttgatgaa accaccaggg catcacatat actaagcatg tgctctacca tcatgctatg     1080

cttccagctc aggggggcac ttttaaggat ctagaaaaca gaaattaagg atctcatagt     1140

tattttatta ggccagcctt attccatgtc ggcaagaggt ttcttgtgga aattatgtcc     1200

tttctgagag gagctgggga ttagatgctc ctgcatttgt gaaatggtta taagcataga     1260

aaaataggtg gtaagctttc cttctttcct tattttgtgt gatgccttaa actgaaaagt     1320

taaaaattga tggattgtag cattcccata atctccccct tctttttttt tcctttggaa     1380

atgtccaata gtctatattc ctctgtcccg cccaaacacc atcttcactc caagcctacc     1440

acagatgcct gaagaagttc ctcactatct gcaaatgtgg ctctcaggcc cttcctgatg     1500

tgatgaatga atctactaat catttcttga ccattcattt tatcacttct aaccttgaaa     1560

catgtggaag tagctatgtt cctgactgtt tcctctgcca gacaatgaac tctggagatc     1620

agggagcttc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcgtgcgc     1680

gcgcgcgtgc gcacgcacgt gcatgcacat gctatgtatt gggtccctcc aaggatgaac     1740

cctctctttg gcttagaagg cactcagaga atatgtgtta ttcgtgctca cggaaagttt     1800

cttactcatc cctgtgactt tggctttatt ttacaataaa acactgaaaa tgtccacttt     1860

gttagttgtg aacatgagcc caggcctaag gtgctgggaa acagaaaggg cgggagattt     1920

ttctttattc tatggctaga aaatagttac ctcctctctg aaagtcttct tcctcatttc     1980

tgggtaacag aatatcaaac accttgctta taagttataa agtagtgttg tccaccatga     2040

acccaccaag taaaaacaac ccaaatacct atcatggatg aataatcatg caagtatcag     2100

atctgcactc aatgccacac aatgacaaag atagcaaatg agccacagac ggctccaccc     2160

aacccaatag atgaacactt ggttcaaaat cactaaagct caaatactcc caggtcaaac     2220

accaggtaac aagttaatac tcaacaaagg gggaaaacaa atgttccact gaatcctgtg     2280

accctgtggg cgtggttcac ctcctgtgtt gtttgccatg tgtgctcagg atgagctgat     2340

taaagctctt ctcaggggtt cagttttccc atctctgctt gtaaataaaa agcttatgca     2400

gaatactga                                                             2409


<210>  62
<211>  160
<212>  PRT
<213>  Mus musculus

<400>  62

Met Asn Lys Glu Lys Glu Leu Arg Ala Ala Ser Pro Ser Leu Arg His 
1               5                   10                  15      


Val Gln Asp Leu Ser Ser Arg Val Trp Ile Leu Gln Asn Asn Ile Leu 
            20                  25                  30          


Thr Ala Val Pro Arg Lys Glu Gln Thr Val Pro Val Thr Ile Thr Leu 
        35                  40                  45              


Leu Pro Cys Gln Tyr Leu Asp Thr Leu Glu Thr Asn Arg Gly Asp Pro 
    50                  55                  60                  


Thr Tyr Met Gly Val Gln Arg Pro Met Ser Cys Leu Phe Cys Thr Lys 
65                  70                  75                  80  


Asp Gly Glu Gln Pro Val Leu Gln Leu Gly Glu Gly Asn Ile Met Glu 
                85                  90                  95      


Met Tyr Asn Lys Lys Glu Pro Val Lys Ala Ser Leu Phe Tyr His Lys 
            100                 105                 110         


Lys Ser Gly Thr Thr Ser Thr Phe Glu Ser Ala Ala Phe Pro Gly Trp 
        115                 120                 125             


Phe Ile Ala Val Cys Ser Lys Gly Ser Cys Pro Leu Ile Leu Thr Gln 
    130                 135                 140                 


Glu Leu Gly Glu Ile Phe Ile Thr Asp Phe Glu Met Ile Val Val His 
145                 150                 155                 160 


<210>  63
<211>  883
<212>  DNA
<213>  Mus musculus

<400>  63
taacctcctc ttttcgtgtt gtggataaaa ggcttggacc ttagtagagc ttgtcagaga       60

agctgagcac agtagtgggt gtagttctgt agtgtgcaga cacattccta ttcaatcagg      120

gtcaatctgc agattggcag ctcagaaaca acatcaccat aatgaataag gagaaagaac      180

taagagcagc atcaccttcg cttagacatg ttcaggatct tagtagtcgt gtgtggatcc      240

tgcagaacaa tatcctcact gcagtcccaa ggaaagagca aacagttcca gtcactatta      300

ccttgctccc atgccaatat ctggacactc ttgagacgaa caggggggat cccacgtaca      360

tgggagtgca aaggccgatg agctgcctgt tctgcacaaa ggatggggag cagcctgtgc      420

tacagcttgg ggaagggaac ataatggaaa tgtacaacaa aaaggaacct gtaaaagcct      480

ctctcttcta tcacaagaag agtggtacaa cctctacatt tgagtctgca gccttccctg      540

gttggttcat cgctgtctgc tctaaaggga gctgcccact cattctgacc caagaactgg      600

gggaaatctt catcactgac ttcgagatga ttgtggtaca ttaaggtttt tagacacatt      660

gctctgtggc actctctcaa gatttcttgg attctaacaa gaagcaatca aagacacccc      720

taacaaaatg gaagactgaa aagaaagctg agccctccct gggctgtttt tccttggtgg      780

tgaatcagat gcagaacatc ttaccatgtt ttcatccaaa gcatttactg ttggttttta      840

caaggagtga attttttaaa ataaaatcat ttatctcatt tgc                        883


