                         SEQUENCE LISTING

<110>  FOUNDATION MEDICINE, INC.
 
<120>  METHODS OF TREATING PEDIATRIC CANCERS

<130>  F2036-7053WO

<150>  61/898,835
<151>  2013-11-01

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  2
<211>  5917
<212>  DNA
<213>  Homo sapiens

<400>  2
agatgcaggg gcgcaaacgc caaaggagac caggctgtag gaagagaagg gcagagcgcc       60

ggacagctcg gcccgctccc cgtcctttgg ggccgcggct ggggaactac aaggcccagc      120

aggcagctgc agggggcgga ggcggaggag ggaccagcgc gggtgggagt gagagagcga      180

gccctcgcgc cccgccggcg catagcgctc ggagcgctct tgcggccaca ggcgcggcgt      240

cctcggcggc gggcggcagc tagcgggagc cgggacgccg gtgcagccgc agcgcgcgga      300

ggaacccggg tgtgccggga gctgggcggc cacgtccgga cgggaccgag acccctcgta      360

gcgcattgcg gcgacctcgc cttccccggc cgcgagcgcg ccgctgcttg aaaagccgcg      420

gaacccaagg acttttctcc ggtccgagct cggggcgccc cgcagggcgc acggtacccg      480

tgctgcagtc gggcacgccg cggcgccggg gcctccgcag ggcgatggag cccggtctgc      540

aaggaaagtg aggcgccgcc gctgcgttct ggaggagggg ggcacaaggt ctggagaccc      600

cgggtggcgg acgggagccc tccccccgcc ccgcctccgg ggcaccagct ccggctccat      660

tgttcccgcc cgggctggag gcgccgagca ccgagcgccg ccgggagtcg agcgccggcc      720

gcggagctct tgcgaccccg ccaggacccg aacagagccc gggggcggcg ggccggagcc      780

ggggacgcgg gcacacgccc gctcgcacaa gccacggcgg actctcccga ggcggaacct      840

ccacgccgag cgagggtcag tttgaaaagg aggatcgagc tcactgtgga gtatccatgg      900

agatgtggag ccttgtcacc aacctctaac tgcagaactg ggatgtggag ctggaagtgc      960

ctcctcttct gggctgtgct ggtcacagcc acactctgca ccgctaggcc gtccccgacc     1020

ttgcctgaac aagcccagcc ctggggagcc cctgtggaag tggagtcctt cctggtccac     1080

cccggtgacc tgctgcagct tcgctgtcgg ctgcgggacg atgtgcagag catcaactgg     1140

ctgcgggacg gggtgcagct ggcggaaagc aaccgcaccc gcatcacagg ggaggaggtg     1200

gaggtgcagg actccgtgcc cgcagactcc ggcctctatg cttgcgtaac cagcagcccc     1260

tcgggcagtg acaccaccta cttctccgtc aatgtttcag atgctctccc ctcctcggag     1320

gatgatgatg atgatgatga ctcctcttca gaggagaaag aaacagataa caccaaacca     1380

aaccgtatgc ccgtagctcc atattggaca tccccagaaa agatggaaaa gaaattgcat     1440

gcagtgccgg ctgccaagac agtgaagttc aaatgccctt ccagtgggac cccaaacccc     1500

acactgcgct ggttgaaaaa tggcaaagaa ttcaaacctg accacagaat tggaggctac     1560

aaggtccgtt atgccacctg gagcatcata atggactctg tggtgccctc tgacaagggc     1620

aactacacct gcattgtgga gaatgagtac ggcagcatca accacacata ccagctggat     1680

gtcgtggagc ggtcccctca ccggcccatc ctgcaagcag ggttgcccgc caacaaaaca     1740

gtggccctgg gtagcaacgt ggagttcatg tgtaaggtgt acagtgaccc gcagccgcac     1800

atccagtggc taaagcacat cgaggtgaat gggagcaaga ttggcccaga caacctgcct     1860

tatgtccaga tcttgaagac tgctggagtt aataccaccg acaaagagat ggaggtgctt     1920

cacttaagaa atgtctcctt tgaggacgca ggggagtata cgtgcttggc gggtaactct     1980

atcggactct cccatcactc tgcatggttg accgttctgg aagccctgga agagaggccg     2040

gcagtgatga cctcgcccct gtacctggag atcatcatct attgcacagg ggccttcctc     2100

atctcctgca tggtggggtc ggtcatcgtc tacaagatga agagtggtac caagaagagt     2160

gacttccaca gccagatggc tgtgcacaag ctggccaaga gcatccctct gcgcagacag     2220

gtaacagtgt ctgctgactc cagtgcatcc atgaactctg gggttcttct ggttcggcca     2280

tcacggctct cctccagtgg gactcccatg ctagcagggg tctctgagta tgagcttccc     2340

gaagaccctc gctgggagct gcctcgggac agactggtct taggcaaacc cctgggagag     2400

ggctgctttg ggcaggtggt gttggcagag gctatcgggc tggacaagga caaacccaac     2460

cgtgtgacca aagtggctgt gaagatgttg aagtcggacg caacagagaa agacttgtca     2520

gacctgatct cagaaatgga gatgatgaag atgatcggga agcataagaa tatcatcaac     2580

ctgctggggg cctgcacgca ggatggtccc ttgtatgtca tcgtggagta tgcctccaag     2640

ggcaacctgc gggagtacct gcaggcccgg aggcccccag ggctggaata ctgctacaac     2700

cccagccaca acccagagga gcagctctcc tccaaggacc tggtgtcctg cgcctaccag     2760

gtggcccgag gcatggagta tctggcctcc aagaagtgca tacaccgaga cctggcagcc     2820

aggaatgtcc tggtgacaga ggacaatgtg atgaagatag cagactttgg cctcgcacgg     2880

gacattcacc acatcgacta ctataaaaag acaaccaacg gccgactgcc tgtgaagtgg     2940

atggcacccg aggcattatt tgaccggatc tacacccacc agagtgatgt gtggtctttc     3000

ggggtgctcc tgtgggagat cttcactctg ggcggctccc cataccccgg tgtgcctgtg     3060

gaggaacttt tcaagctgct gaaggagggt caccgcatgg acaagcccag taactgcacc     3120

aacgagctgt acatgatgat gcgggactgc tggcatgcag tgccctcaca gagacccacc     3180

ttcaagcagc tggtggaaga cctggaccgc atcgtggcct tgacctccaa ccaggagtac     3240

ctggacctgt ccatgcccct ggaccagtac tcccccagct ttcccgacac ccggagctct     3300

acgtgctcct caggggagga ttccgtcttc tctcatgagc cgctgcccga ggagccctgc     3360

ctgccccgac acccagccca gcttgccaat ggcggactca aacgccgctg actgccaccc     3420

acacgccctc cccagactcc accgtcagct gtaaccctca cccacagccc ctgctgggcc     3480

caccacctgt ccgtccctgt cccctttcct gctggcagga gccggctgcc taccaggggc     3540

cttcctgtgt ggcctgcctt caccccactc agctcacctc tccctccacc tcctctccac     3600

ctgctggtga gaggtgcaaa gaggcagatc tttgctgcca gccacttcat cccctcccag     3660

atgttggacc aacacccctc cctgccacca ggcactgcct ggagggcagg gagtgggagc     3720

caatgaacag gcatgcaagt gagagcttcc tgagctttct cctgtcggtt tggtctgttt     3780

tgccttcacc cataagcccc tcgcactctg gtggcaggtg ccttgtcctc agggctacag     3840

cagtagggag gtcagtgctt cgtgcctcga ttgaaggtga cctctgcccc agataggtgg     3900

tgccagtggc ttattaattc cgatactagt ttgctttgct gaccaaatgc ctggtaccag     3960

aggatggtga ggcgaaggcc aggttggggg cagtgttgtg gccctggggc ccagccccaa     4020

actgggggct ctgtatatag ctatgaagaa aacacaaagt gtataaatct gagtatatat     4080

ttacatgtct ttttaaaagg gtcgttacca gagatttacc catcgggtaa gatgctcctg     4140

gtggctggga ggcatcagtt gctatatatt aaaaacaaaa aagaaaaaaa aggaaaatgt     4200

ttttaaaaag gtcatatatt ttttgctact tttgctgttt tattttttta aattatgttc     4260

taaacctatt ttcagtttag gtccctcaat aaaaattgct gctgcttcat ttatctatgg     4320

gctgtatgaa aagggtggga atgtccactg gaaagaaggg acacccacgg gccctggggc     4380

taggtctgtc ccgagggcac cgcatgctcc cggcgcaggt tccttgtaac ctcttcttcc     4440

taggtcctgc acccagacct cacgacgcac ctcctgcctc tccgctgctt ttggaaagtc     4500

agaaaaagaa gatgtctgct tcgagggcag gaaccccatc catgcagtag aggcgctggg     4560

cagagagtca aggcccagca gccatcgacc atggatggtt tcctccaagg aaaccggtgg     4620

ggttgggctg gggagggggc acctacctag gaatagccac ggggtagagc tacagtgatt     4680

aagaggaaag caagggcgcg gttgctcacg cctgtaatcc cagcactttg ggacaccgag     4740

gtgggcagat cacttcaggt caggagtttg agaccagcct ggccaactta gtgaaacccc     4800

atctctacta aaaatgcaaa aattatccag gcatggtggc acacgcctgt aatcccagct     4860

ccacaggagg ctgaggcaga atcccttgaa gctgggaggc ggaggttgca gtgagccgag     4920

attgcgccat tgcactccag cctgggcaac agagaaaaca aaaaggaaaa caaatgatga     4980

aggtctgcag aaactgaaac ccagacatgt gtctgccccc tctatgtggg catggttttg     5040

ccagtgcttc taagtgcagg agaacatgtc acctgaggct agttttgcat tcaggtccct     5100

ggcttcgttt cttgttggta tgcctcccca gatcgtcctt cctgtatcca tgtgaccaga     5160

ctgtatttgt tgggactgtc gcagatcttg gcttcttaca gttcttcctg tccaaactcc     5220

atcctgtccc tcaggaacgg ggggaaaatt ctccgaatgt ttttggtttt ttggctgctt     5280

ggaatttact tctgccacct gctggtcatc actgtcctca ctaagtggat tctggctccc     5340

ccgtacctca tggctcaaac taccactcct cagtcgctat attaaagctt atattttgct     5400

ggattactgc taaatacaaa agaaagttca atatgttttc atttctgtag ggaaaatggg     5460

attgctgctt taaatttctg agctagggat tttttggcag ctgcagtgtt ggcgactatt     5520

gtaaaattct ctttgtttct ctctgtaaat agcacctgct aacattacaa tttgtattta     5580

tgtttaaaga aggcatcatt tggtgaacag aactaggaaa tgaattttta gctcttaaaa     5640

gcatttgctt tgagaccgca caggagtgtc tttccttgta aaacagtgat gataatttct     5700

gccttggccc taccttgaag caatgttgtg tgaagggatg aagaatctaa aagtcttcat     5760

aagtccttgg gagaggtgct agaaaaatat aaggcactat cataattaca gtgatgtcct     5820

tgctgttact actcaaatca cccacaaatt tccccaaaga ctgcgctagc tgtcaaataa     5880

aagacagtga aattgacctg aaaaaaaaaa aaaaaaa                              5917


<210>  3
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210>  4
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  4
cgcctccctt ccccctcccc gcccgacagc ggccgctcgg gccccggctc tcggttataa       60

gatggcggcg ctgagcggtg gcggtggtgg cggcgcggag ccgggccagg ctctgttcaa      120

cggggacatg gagcccgagg ccggcgccgg cgccggcgcc gcggcctctt cggctgcgga      180

ccctgccatt ccggaggagg tgtggaatat caaacaaatg attaagttga cacaggaaca      240

tatagaggcc ctattggaca aatttggtgg ggagcataat ccaccatcaa tatatctgga      300

ggcctatgaa gaatacacca gcaagctaga tgcactccaa caaagagaac aacagttatt      360

ggaatctctg gggaacggaa ctgatttttc tgtttctagc tctgcatcaa tggataccgt      420

tacatcttct tcctcttcta gcctttcagt gctaccttca tctctttcag tttttcaaaa      480

tcccacagat gtggcacgga gcaaccccaa gtcaccacaa aaacctatcg ttagagtctt      540

cctgcccaac aaacagagga cagtggtacc tgcaaggtgt ggagttacag tccgagacag      600

tctaaagaaa gcactgatga tgagaggtct aatcccagag tgctgtgctg tttacagaat      660

tcaggatgga gagaagaaac caattggttg ggacactgat atttcctggc ttactggaga      720

agaattgcat gtggaagtgt tggagaatgt tccacttaca acacacaact ttgtacgaaa      780

aacgtttttc accttagcat tttgtgactt ttgtcgaaag ctgcttttcc agggtttccg      840

ctgtcaaaca tgtggttata aatttcacca gcgttgtagt acagaagttc cactgatgtg      900

tgttaattat gaccaacttg atttgctgtt tgtctccaag ttctttgaac accacccaat      960

accacaggaa gaggcgtcct tagcagagac tgccctaaca tctggatcat ccccttccgc     1020

acccgcctcg gactctattg ggccccaaat tctcaccagt ccgtctcctt caaaatccat     1080

tccaattcca cagcccttcc gaccagcaga tgaagatcat cgaaatcaat ttgggcaacg     1140

agaccgatcc tcatcagctc ccaatgtgca tataaacaca atagaacctg tcaatattga     1200

tgacttgatt agagaccaag gatttcgtgg tgatggagga tcaaccacag gtttgtctgc     1260

taccccccct gcctcattac ctggctcact aactaacgtg aaagccttac agaaatctcc     1320

aggacctcag cgagaaagga agtcatcttc atcctcagaa gacaggaatc gaatgaaaac     1380

acttggtaga cgggactcga gtgatgattg ggagattcct gatgggcaga ttacagtggg     1440

acaaagaatt ggatctggat catttggaac agtctacaag ggaaagtggc atggtgatgt     1500

ggcagtgaaa atgttgaatg tgacagcacc tacacctcag cagttacaag ccttcaaaaa     1560

tgaagtagga gtactcagga aaacacgaca tgtgaatatc ctactcttca tgggctattc     1620

cacaaagcca caactggcta ttgttaccca gtggtgtgag ggctccagct tgtatcacca     1680

tctccatatc attgagacca aatttgagat gatcaaactt atagatattg cacgacagac     1740

tgcacagggc atggattact tacacgccaa gtcaatcatc cacagagacc tcaagagtaa     1800

taatatattt cttcatgaag acctcacagt aaaaataggt gattttggtc tagctacagt     1860

gaaatctcga tggagtgggt cccatcagtt tgaacagttg tctggatcca ttttgtggat     1920

ggcaccagaa gtcatcagaa tgcaagataa aaatccatac agctttcagt cagatgtata     1980

tgcatttgga attgttctgt atgaattgat gactggacag ttaccttatt caaacatcaa     2040

caacagggac cagataattt ttatggtggg acgaggatac ctgtctccag atctcagtaa     2100

ggtacggagt aactgtccaa aagccatgaa gagattaatg gcagagtgcc tcaaaaagaa     2160

aagagatgag agaccactct ttccccaaat tctcgcctct attgagctgc tggcccgctc     2220

attgccaaaa attcaccgca gtgcatcaga accctccttg aatcgggctg gtttccaaac     2280

agaggatttt agtctatatg cttgtgcttc tccaaaaaca cccatccagg cagggggata     2340

tggtgcgttt cctgtccact gaaacaaatg agtgagagag ttcaggagag tagcaacaaa     2400

aggaaaataa atgaacatat gtttgcttat atgttaaatt gaataaaata ctctcttttt     2460

ttttaaggtg aaccaaagaa cacttgtgtg gttaaagact agatataatt tttccccaaa     2520

ctaaaattta tacttaacat tggattttta acatccaagg gttaaaatac atagacattg     2580

ctaaaaattg gcagagcctc ttctagaggc tttactttct gttccgggtt tgtatcattc     2640

acttggttat tttaagtagt aaacttcagt ttctcatgca acttttgttg ccagctatca     2700

catgtccact agggactcca gaagaagacc ctacctatgc ctgtgtttgc aggtgagaag     2760

ttggcagtcg gttagcctgg gttagataag gcaaactgaa cagatctaat ttaggaagtc     2820

agtagaattt aataattcta ttattattct taataatttt tctataacta tttcttttta     2880

taacaatttg gaaaatgtgg atgtctttta tttccttgaa gcaataaact aagtttcttt     2940

ttataaaaa                                                             2949


<210>  5
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  6
<211>  2020
<212>  DNA
<213>  Homo sapiens

<400>  6
cacctcctgt ccgcccctca gcgcatgggt ggcggtcacg tgcccagaac gtccggcgtt       60

cgccccgccc tcccagtttc cgcgcgcctc tttggcagct ggtcacatgg tgagggtggg      120

ggtgaggggg cctctctagc ttgcggcctg tgtctatggt cgggccctct gcgtccagct      180

gctccggacc gagctcgggt gtatggggcc gtaggaaccg gctccggggc cccgataacg      240

ggccgccccc acagcacccc gggctggcgt gagggtctcc cttgatctga gaatggctac      300

ctctcgatat gagccagtgg ctgaaattgg tgtcggtgcc tatgggacag tgtacaaggc      360

ccgtgatccc cacagtggcc actttgtggc cctcaagagt gtgagagtcc ccaatggagg      420

aggaggtgga ggaggccttc ccatcagcac agttcgtgag gtggctttac tgaggcgact      480

ggaggctttt gagcatccca atgttgtccg gctgatggac gtctgtgcca catcccgaac      540

tgaccgggag atcaaggtaa ccctggtgtt tgagcatgta gaccaggacc taaggacata      600

tctggacaag gcacccccac caggcttgcc agccgaaacg atcaaggatc tgatgcgcca      660

gtttctaaga ggcctagatt tccttcatgc caattgcatc gttcaccgag atctgaagcc      720

agagaacatt ctggtgacaa gtggtggaac agtcaagctg gctgactttg gcctggccag      780

aatctacagc taccagatgg cacttacacc cgtggttgtt acactctggt accgagctcc      840

cgaagttctt ctgcagtcca catatgcaac acctgtggac atgtggagtg ttggctgtat      900

ctttgcagag atgtttcgtc gaaagcctct cttctgtgga aactctgaag ccgaccagtt      960

gggcaaaatc tttgacctga ttgggctgcc tccagaggat gactggcctc gagatgtatc     1020

cctgccccgt ggagcctttc cccccagagg gccccgccca gtgcagtcgg tggtacctga     1080

gatggaggag tcgggagcac agctgctgct ggaaatgctg acttttaacc cacacaagcg     1140

aatctctgcc tttcgagctc tgcagcactc ttatctacat aaggatgaag gtaatccgga     1200

gtgagcaatg gagtggctgc catggaagga agaaaagctg ccatttccct tctggacact     1260

gagagggcaa tctttgcctt tatctctgag gctatggagg gtcctcctcc atctttctac     1320

agagattact ttgctgcctt aatgacattc ccctcccacc tctccttttg aggcttctcc     1380

ttctccttcc catttctcta cactaagggg tatgttccct cttgtccctt tccctacctt     1440

tatatttggg gtcctttttt atacaggaaa aacaaaacaa agaaataatg gtcttttttt     1500

tttttttaat gtttcttcct ctgtttggct ttgccattgt gcgatttgga aaaaccactt     1560

ggaagaaggg actttcctgc aaaaccttaa agactggtta aattacaggg cctaggaagt     1620

cagtggagcc ccttgactga caaagcttag aaaggaactg aaattgcttc tttgaatatg     1680

gattttaggc ggggcgtggt ggctcacgcc tataatccca gcacgttggg aggccaacgc     1740

gggtggatca cctgaggtca ggagttcgag accagcctga ctaacatggt gaaaccctgt     1800

ctctactaaa aatacaaaat tagtcaggcg tggtggtgca cacctgtaat cccagctact     1860

tgggagactg aggcaggagg atcgcttgaa cccgggaggc agaggttgcg gtgagccgag     1920

atcatgccat tgcactccag cctgggcaac agagcaagac tctgtgtcaa aaaaaaaaaa     1980

agaatataga tttttaaatg gcaaaaaaaa aaaaaaaaaa                           2020


<210>  7
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  8
<211>  11628
<212>  DNA
<213>  Homo sapiens

<400>  8
aacctctccg cgcgaagacg gcttcagccc tgcagggaaa gaaaagtgca atgattctgg       60

actgagacgc gcttgggcag aggctatgta atcgtgtctg tgttgaggac ttcgcttcga      120

ggagggaaga ggagggatcg gctcgctcct ccggcggcgg cggcggcggc gactctgcag      180

gcggagtttc gcggcggcgg caccagggtt acgccagccc cgcggggagg tctctccatc      240

cagcttctgc agcggcgaaa gccccagcgc ccgagcgcct gagccggcgg ggagcaagta      300

aagctagacc gatctccggg gagccccgga gtaggcgagc ggcggccgcc agctagttga      360

gcgcaccccc cgcccgcccc agcggcgccg cggcgggcgg cgtccaggcg gcatggagaa      420

ggacggcctg tgccgcgctg accagcagta cgaatgcgtg gcggagatcg gggagggcgc      480

ctatgggaag gtgttcaagg cccgcgactt gaagaacgga ggccgtttcg tggcgttgaa      540

gcgcgtgcgg gtgcagaccg gcgaggaggg catgccgctc tccaccatcc gcgaggtggc      600

ggtgctgagg cacctggaga ccttcgagca ccccaacgtg gtcaggttgt ttgatgtgtg      660

cacagtgtca cgaacagaca gagaaaccaa actaacttta gtgtttgaac atgtcgatca      720

agacttgacc acttacttgg ataaagttcc agagcctgga gtgcccactg aaaccataaa      780

ggatatgatg tttcagcttc tccgaggtct ggactttctt cattcacacc gagtagtgca      840

tcgcgatcta aaaccacaga acattctggt gaccagcagc ggacaaataa aactcgctga      900

cttcggcctt gcccgcatct atagtttcca gatggctcta acctcagtgg tcgtcacgct      960

gtggtacaga gcacccgaag tcttgctcca gtccagctac gccacccccg tggatctctg     1020

gagtgttggc tgcatatttg cagaaatgtt tcgtagaaag cctctttttc gtggaagttc     1080

agatgttgat caactaggaa aaatcttgga cgtgattgga ctcccaggag aagaagactg     1140

gcctagagat gttgcccttc ccaggcaggc ttttcattca aaatctgccc aaccaattga     1200

gaagtttgta acagatatcg atgaactagg caaagaccta cttctgaagt gtttgacatt     1260

taacccagcc aaaagaatat ctgcctacag tgccctgtct cacccatact tccaggacct     1320

ggaaaggtgc aaagaaaacc tggattccca cctgccgccc agccagaaca cctcggagct     1380

gaatacagcc tgaggcctca gcagccgcct taagctgatc ctgcggagaa cacccttggt     1440

ggcttatggg tccccctcag caagccctac agagctgtgg aggattgcta tctggaggcc     1500

ttccagctgc tgtcttctgg acaggctctg cttctccaag gaaaccgcct agtttactgt     1560

tttgaaatca atgcaagagt gattgcagct ttatgttcat ttgtttgttt gtttgtctgt     1620

ttgtttcaag aacctggaaa aattccagaa gaagagaagc tgctgaccaa ttgtgctgcc     1680

atttgatttt tctaaccttg aatgctgcca gtgtggagtg ggtaatccag gcacagctga     1740

gttatgatgt aatctctctg cagctgccgg gcctgatttg gtacttttga gtgtgtgtgt     1800

gcatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gagagattct gtgatctttt     1860

aaagtgttac tttttgtaaa cgacaagaat aattcaattt taaagactca aggtggtcag     1920

taaataacag gcatttgttc actgaaggtg attcaccaaa atagtcttct caaattagaa     1980

agttaacccc atgtcctcag catttctttt ctggccaaaa gcagtaaatt tgctagcagt     2040

aaaagatgaa gttttataca cacagcaaaa aggagaaaaa attctagtat attttaagag     2100

atgtgcatgc attctattta gtcttcagaa tgctgaattt acttgttgta agtctatttt     2160

aaccttctgt atgacatcat gctttatcat ttcttttgga aaatagcctg taagcttttt     2220

attacttgct ataggtttag ggagtgtacc tcagatagat tttaaaaaaa agaatagaaa     2280

gcctttattt cctggtttga aattcctttc ttcccttttt ttgttgttgt tattgttgtt     2340

tgttgttgtt attttgtttt tgtttttagg aatttgtcag aaactctttc ctgttttggt     2400

ttggagagta gttctctcta actagagaca ggagtggcct tgaaattttc ctcatctatt     2460

acactgtact ttctgccaca cactgccttg ttggcaaagt atccatcttg tctatctccc     2520

ggcacttctg aaatatattg ctaccattgt ataactaata acagattgct taagctgttc     2580

ccatgcacca cctgtttgct tgctttcaat gaacctttca taaattcgca gtctcagctt     2640

atggtttatg gcctcgattc tgcaaaccta acagggtcac atatgttctc taatgcagtc     2700

cttctacctg gtgtttactt ttgttaccta aataatgagt aggatcttgt tttgttttat     2760

caccagcaca cagattgcta taaactgtta ctttgtgaat tacattttta tagaagatat     2820

tttcagtgtc tttacctgag ggtatgtctt tagctatgtt ttagggccat acatttactc     2880

tatcaaatga tcttttctcc atcccccagg ctgtgcttat ttctagtgcc ttgtgctcac     2940

tcctgctctc tacagagcca gcctggcctg ggcattgtaa acagcttttc ctttttctct     3000

tactgttttc tctacagtcc tttatatttc ataccatctc tgccttataa gtggtttagt     3060

gctcagttgg ctctagtaac cagaggacac agaaagtatc ttttggaaag tttagccacc     3120

tgtgctttct gactcagagt gcatgcaaca gttagatcat gcaacagtta gattatgttt     3180

agggttagga ttttcaaaga atggaggttg ctgcactcag aaaataattc agatcatgtt     3240

tatgcattat taagttgtac tgaattcttt gcagcttaat gtgatatatg actatcttga     3300

acaagagaaa aaactaggag atgtttctcc tgaagagctt ttggggttgg gaactattct     3360

tttttaattg ctgtactact taacattgtt ctaattcagt agcttgagga acaggaacat     3420

tgttttctag agcaagataa taaaggagat gggccataca aatgttttct actttcgttg     3480

tgacaacatt gattaggtgt tgtcagtact ataaatgctt gagatataat gaatccacag     3540

cattcaaggt caggtctact caaagtctca catggaaaag tgagttctgc ctttcctttg     3600

atcgagggtc aaaatacaaa gacatttttg ctagggccta caaattgaat ttaaaaactc     3660

actgcactga ttcatctgag ctttttggtt agtattcatg gctagagtga acatagcttt     3720

agtttttgct gttgtaaaag tgttttcata agttcactca agaaaaatgc agctgttctg     3780

aactggaatt tttcagcatt ctttagaatt ttaaatgagt agagagctca acttttattc     3840

ctagcatctg cttttgactc atttctaggc agtgcttatg aagaaaaatt aaagcacaaa     3900

cattctggca ttcaatcgtt ggcagattat cttctgatga cacagaatga aagggcatct     3960

cagcctctct gaactttgta aaaatctgtc cccagttctt ccatcggtgt agttgttgca     4020

tttgagtgaa tactctcttg atttatgtat tttatgtcca gattcgccat ttctgaaatc     4080

cagatccaac acaagcagtc ttgccgttag ggcattttga agcagatagt agagtaagaa     4140

cttagtgact acagcttatt cttctgtaac atatggtttc aaacatcttt gccaaaagct     4200

aagcagtggt gaactgaaaa gggcatattg ccccaaggtt acactgaagc agctcatagc     4260

aagttaaaat attgtgacag atttgaaatc atgtttgaat ttcatagtag gaccagtaca     4320

agaatgtccc tgctagtttc tgtttgatgt ttggttctgg cggctcaggc attttgggaa     4380

ctgttgcaca gggtggagtc aaaacaacct acatataaaa agagaaaaag agaaacttgt     4440

ccatttagct ttcataagaa atcccatggc aaagggtaat aaaaaggacc taatcttaaa     4500

aatacaattt ctaagcactt gtaagaaccc agtgggttgg agcctcccac tttgtccctc     4560

ctttgaagtg gatgggaact caaggtgcaa agaacctgtt ttggaagaaa gcttggggcc     4620

atttcagccc cctgtattct catgattttc tctcaggaag cacacactgt gaatggcaga     4680

cttttcattt agccccaggt gacttactaa aaatagttga aaattattca cctaagaata     4740

gaatctcagc attgtgttaa ataaaaatga aagctttaga aggcatgaga tgttcctatc     4800

ttaaataaag catgtttctt ttctatagag aaatgtatag tttgactctc cagaatgtac     4860

tatccatctt gatgagaaaa ctcttaaata gtaccaaaca ttttgaactt taaattatgt     4920

atttaaagtg agtgtttaag aaactgtagc tgcttctttt acaagtggtg cctattaaag     4980

tcagtaatgg ccattattgt tccattgtgg aaattaaatt atgtaagctt cctaatatca     5040

taaacatatt aaaattcttc taaaatattg cttttctttt aagtgacaat ttgactattc     5100

ttatgataag cacatgagag tgtcttacat tttccaaaag caggctttaa ttgcatagtt     5160

gagtctagga aaaaataatg ttaaaagtga atatgccacc ataattactt aattatgtta     5220

gtatagaaac tacagaatat ttaccctgga aagaaaatat tggaatgtta ttataaactc     5280

ttagatattt atataattca aaagaatgca tgtttcacat tgtgacagat aaagatgtat     5340

gatttctaag gctttaaaaa ttattcataa aacagtgggc aatagataaa ggaaattctg     5400

gagaaaatga aggtatttaa agggtagttt caaagctata tatattttga aggatatatt     5460

ctttatgaac aaatatattg taaaaattta tactaaggtc atctggtaac tgtgggatta     5520

atatggtcga aaacaaatgt tatggagaag ctgtcccaag caaactaaat tacctgtact     5580

tttttcccat ttcaagggaa gaggcaacca catgaagcaa tacttcttac acatgcctaa     5640

gaacgttcat tgaaaaaata aatttttaaa aggcatgtgt ttcctatgcc accaatactt     5700

ttgaaaaatt gtgaacctta cccaaaacca tttatcatgt ccattaagta tatttgggta     5760

tataattagg aagatattta catgttccat ctccacagtg gaaaaactta ttgaggctac     5820

caaagtgtgc caagaaatgt aagtccttag agtaattaga aatgctgttt tcctcaaaag     5880

catgagaaac tagcattttc atttcttatt tactcccttt ctatatcaat gcaattcaca     5940

acccaatttt aatacatccc tatatctcaa gcatttctat cttgtacttt ttcagaaaat     6000

aaaccaaaaa taatcctttg gtctctctat cttctgacct ttgtaagcaa cagaaatgta     6060

aaaacagaag gggtccaatt tttacacgtt tttttctcaa gtagcctttc tggggatttt     6120

tattttctta atgaagtgcc aatcagcttt tcaaaatgtt ttctatttct cagcatttcc     6180

aggaagtgat aacgtttagc taaatgagta gaagtggact tccttcaaca tattgttacc     6240

ttgtctagcc ttaggaagaa aacaagagcc acctgaaaat aaatacaggc tcttttcgag     6300

catctgctga aatactgtta cagcaatttg aagttgatgt ggtaggaaag gaaggtgact     6360

tttcttgcaa aagtctttct aaacattcac actgtcctaa gagatgagct ttcttgtttt     6420

attccggtat attccacaag gtggcacttt tagagaaaaa caaatctgat gaagactaaa     6480

gaggtacttc taaaagagat ttcattctaa ctttattttt ctgcgcatat ttaactcttt     6540

cctagcactt gttttttggg atgattaata gtctctataa tgttctgtaa cttcaatatt     6600

ttacttgtta cctaggttct gaacaattgt ctgcaaataa attgttctta aggatggata     6660

atacacccat tttgatcatt taagtaaaga aagcctagtc attcattcag tcaagaaaaa     6720

atttttgaag tacccagtta ccttactttt ctagattaaa acaggcttag ttactaaaaa     6780

ggcagtcctc atctgtgaac aggatagttt cgttagaagt ataaaactcc tttagtggcc     6840

ccagttaaaa cacacatacc ctctctgctg ctttcaaatt ccctagcatg gtggcctttc     6900

aacattgatt aaattttaaa atcctaattt aaagatcagg tgagcaaaat gagtagcaca     6960

tcagtaattc agtagacaaa acttttgtct gaaaaattgc tgtattgaaa cagagcccta     7020

aaataccaaa agaccaggta attttaacat ttgtggaatc acaaatgtaa attcataaga     7080

agctctaatt aaaaaaaaaa agtctgaagt atatgagcat aacaacttag gagtgtgtct     7140

acatacttaa cttttgaagt tttttggcaa ctttatatac tttttttaaa tttacaagtc     7200

tacttaaaga cttcttatac cccaaatgat taagttaatt ttagaggtca cctttctcac     7260

agcagtgtca cttgaaattt agtagggaag gatattgcag tatttttcag tttccttagc     7320

acagcaccac agaaagcagc ttattccttt tgagtggcag acactcgacg gtgcctgccc     7380

aactttcctc ctgagtggca agcagatgag tctcagtaat tcatactgaa ccaaaatgcc     7440

acatacacta ggggcagtca gaaactggct gagaaatccc ccgcctcatt cgcccctctg     7500

ctcccaggaa ctagagtcca gttaaagccc ctatgcgaaa ggccgaattc caccccaggg     7560

tttgttataa cagtggccag tctgaacccc atttgctcgt gctcaaaact tgattcccac     7620

ttgaaagcct tccgggcgcg ctgcctcgtt gccccgcccc tttggcagga gagaggcagt     7680

gggcgaggcc gggctggggc cccgcctccc actcacctgc cggtgcctga aattatgtgc     7740

ggccccgcgg gctgctttcc gaggtcagag tgccctgctg ctgtctcaga ggcatctgtt     7800

ctgcaaatct taggaagaaa aatgtcccta gtagcaaacg ggtgtcttct gtgcataaat     7860

aagtacaaca caattctccg aaagttcggg taaaaagaga tgcggtagca gctgccctgt     7920

gtgaagctgt ctaccccgca tctctcaggc gctaagctca gtttttgttt ttgtttttgt     7980

ttttttaaag aaaagatgta taattgcagg aatttttttt tattttttta ttttccatca     8040

ttctatatat gtgatggtga aagatatgcc tggaaaagtt ttgttttgaa aagtttattt     8100

tctgcttcgt cttcagttgg caaaagctct caattcttta gcttccagtt tcttttctct     8160

ctttttcttt gttaggtaat taaaggtatg taaacaaatt atctcatgta gcaggggatt     8220

ttcatgttga gaggaatctt ccgtgtgagt tgtttggtca cacaaataac cctttctcaa     8280

ttttaggagt ttggattgtc aaatgtaggt ttttctcaaa gggggcatat aactacatat     8340

tgactgccaa gaactatgac tgtagcacta atcagcacac atagagccac acaattattt     8400

aatttctaac tctctgtggt ccctagaaaa attccgttga tgtgcttagg ttaaagttct     8460

gaagataccc gttgtaccct tacttgaaag tttctaatct taagttttat gaaatgcaat     8520

aatatgtatc agctagcaat atttctgtga tcaccaacaa ctctcagttt gatcttaaag     8580

tctgaataat aaaacaaatc ccagcagtaa tacatttctt aaacctcaca gtgcatgata     8640

tatcttttca ttctgatcct gtgtttgcaa aaatatacac atgtatatca tagttcctca     8700

ctttttattc atttgttttc ctattacctg tagtaaatat attagttagt acatggaatt     8760

tatagcatca gctaccccca ggaacagcac ctgacaggcg ggggattttt tttcaagttg     8820

ttctacattt gcataaatta tttctattat tattcatgta tgttatttat ttctgaatca     8880

cactagtcct gtgaaagtac aactgaaggc agaaagtgtt aggattttgc atctaatgtt     8940

cattatcatg gtattgatgg acctaagaaa ataaaaatta gactaagccc ccaaataagc     9000

tgcatgcatt tgtaacatga ttagtagatt tgaatatata gatgtagtat tttgggtatc     9060

taggtgtttt atcattatgt aaaggaatta aagtaaagga ctttgtagtt gtttttatta     9120

aatatgcata tagtagagtg caaaaatata gcaaaaataa aaactaaagg tagaaaagca     9180

ttttagatat gccttaattt agaaactgtg ccaggtggcc ctcggaatag atgccaggca     9240

gagaccagtg cctgggtggt gcctcctctt gtctgccctc atgaagaagc ttccctcacg     9300

tgatgtagtg ccctcgtagg tgtcatgtgg agtagtggga acaggcagta ctgttgagag     9360

gagagcagtg tgagagtttt tctgtagaag cagaactgtc agcttgtgcc ttgaggcttc     9420

cagaacgtgt cagatggaga agtccaagtt tccatgcttc aggcaactta gctgtgtaca     9480

gaagcaatcc agtgtggtaa taaaaagcaa ggattgcctg tataatttat tataaaataa     9540

aagggatttt aacaaccaac aattcccaac acctcaaaag cttgttgcat tttttggtat     9600

ttgaggtttt tatctgaagg ttaaagggca agtgtttggt atagaagagc agtatgtgtt     9660

aagaaaagaa aaatattggt tcacgtagag tgcaaattag aactagaaag ttttatacga     9720

ttatcatttt gagatgtgtt aaagtaggtt ttcactgtaa aatgtattag tgtttctgca     9780

ttgccatagg gcctggttaa aactttctct taggtttcag gaagactgtc acatacagta     9840

agcttttttc cttctgactt ataatagaaa atgttttgaa agtaaaaaaa aaaaatctaa     9900

tttggaaatt tgacttgtta gtttctgtgt ttgaaatcat ggttctagaa atgtagaaat     9960

tgtgtatatc agatactcat ctaggctgtg tgaaccagcc caagatgacc aacatcccca    10020

cacctctaca tctctgtccc ctgtatctct tcctttctac cactaaagtg ttccctgcta    10080

ccatcctggc ttgtccacat ggtgctctcc atcttcctcc acatcatgga ccacaggtgt    10140

gcctgtctag gcctggccac cactcccaac ttgacctagc cacattcatc tagagatggt    10200

tcctgatgct gggcacagac tgtgctcatg gcacccatta gaaatgcctc tagcatcttt    10260

gtatgcatct tgatttttaa accaagtcat tgtacagagc attcagtttt ggctgtggta    10320

ccaagagaaa aactaatcaa gaatataaac cacattccag gctgctgttt tctctccatc    10380

tacaggccac acttttactg tatttcttca tacttgaaat tcattctgct attttcatat    10440

cagggtacag acttataagg gtgcatgttc cttaaaggtg cataattatt cttattccgt    10500

ttgcttatat tgctacagaa tgctctgttt tggtgctttg agttctgcag acccaagaag    10560

cagtgtggaa attcactgcc tgggacacag tcttataaga atgttggcag gtgactttgt    10620

atcagatgtt gcttctcttt tctctgtaca cagattgaga gttaccacag tggcctgtcg    10680

ggtccaccct gtgggtgcag cacagctctc tgaaagcaag aaccttccta cctattctaa    10740

cgtttttgcc ctctaagaaa aatggcctca ggtatggtat agacatagca agaggggaag    10800

ggctgtctca ctctagcaac catccctcca ttacacacag aaagccctct tgaagcaaaa    10860

gaagaagaaa gaaagaaagc ttatctctaa ggctactgtc ttcagaatgc tctgagctga    10920

atgctcttgc tcctttccca agaggcagat gaaaatatag ccagtttatc tatacccttc    10980

ctatctgagg aggagaatag aaaagtaggg taaatatgta acgtaaaata tgtcattcaa    11040

ggaccaccaa aactttaagt accctatcat taaaaatctg gttttaaaag tagctcaagt    11100

aagggatgct ttgtgaccca gggtttctga agtcagatag ccattcttac ctgcccctta    11160

ctctgactta ttgggaaagg gagaactgca gtggtgtttc tgttgcagtg gcaaaggtaa    11220

catgtcagaa aattcagagg gttgcatacc aataatcctt tggaaactgg atgtcttact    11280

gggtgctaga atgaaaatgt aggtatttat tgtcagatga tgaagttcat tgtttttttc    11340

aaaattggtg ttgaaatatc actgtccaat gtgttcactt atgtgaaagc taaattgaat    11400

gaggcaaaaa gagcaaatag tttgtatatt tgtaatacct tttgtatttc ttacaataaa    11460

aatattggta gcaaataaaa ataataaaaa caataacttt aaactgcttt ctggagatga    11520

attactctcc tggctatttt cttttttact ttaatgtaaa atgagtataa ctgtagtgag    11580

taaaattcat taaattccaa gttttagcag aaaaaaaaaa aaaaaaaa                 11628


<210>  9
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  10
<211>  6267
<212>  DNA
<213>  Homo sapiens

<400>  10
agctgcaagt ggcgggcgcc caggcagatg cgatccagcg gctctggggg cggcagcggt       60

ggtagcagct ggtacctccc gccgcctctg ttcggagggt cgcggggcac cgaggtgctt      120

tccggccgcc ctctggtcgg ccacccaaag ccgcgggcgc tgatgatggg tgaggagggg      180

gcggcaagat ttcgggcgcc cctgccctga acgccctcag ctgctgccgc cggggccgct      240

ccagtgcctg cgaactctga ggagccgagg cgccggtgag agcaaggacg ctgcaaactt      300

gcgcagcgcg ggggctggga ttcacgccca gaagttcagc aggcagacag tccgaagcct      360

tcccgcagcg gagagatagc ttgagggtgc gcaagacggc agcctccgcc ctcggttccc      420

gcccagaccg ggcagaagag cttggaggag ccaaaaggaa cgcaaaaggc ggccaggaca      480

gcgtgcagca gctgggagcc gccgttctca gccttaaaag ttgcagagat tggaggctgc      540

cccgagaggg gacagacccc agctccgact gcggggggca ggagaggacg gtacccaact      600

gccacctccc ttcaaccata gtagttcctc tgtaccgagc gcagcgagct acagacgggg      660

gcgcggcact cggcgcggag agcgggaggc tcaaggtccc agccagtgag cccagtgtgc      720

ttgagtgtct ctggactcgc ccctgagctt ccaggtctgt ttcatttaga ctcctgctcg      780

cctccgtgca gttgggggaa agcaagagac ttgcgcgcac gcacagtcct ctggagatca      840

ggtggaagga gccgctgggt accaaggact gttcagagcc tcttcccatc tcggggagag      900

cgaagggtga ggctgggccc ggagagcagt gtaaacggcc tcctccggcg ggatgggagc      960

catcgggctc ctgtggctcc tgccgctgct gctttccacg gcagctgtgg gctccgggat     1020

ggggaccggc cagcgcgcgg gctccccagc tgcggggccg ccgctgcagc cccgggagcc     1080

actcagctac tcgcgcctgc agaggaagag tctggcagtt gacttcgtgg tgccctcgct     1140

cttccgtgtc tacgcccggg acctactgct gccaccatcc tcctcggagc tgaaggctgg     1200

caggcccgag gcccgcggct cgctagctct ggactgcgcc ccgctgctca ggttgctggg     1260

gccggcgccg ggggtctcct ggaccgccgg ttcaccagcc ccggcagagg cccggacgct     1320

gtccagggtg ctgaagggcg gctccgtgcg caagctccgg cgtgccaagc agttggtgct     1380

ggagctgggc gaggaggcga tcttggaggg ttgcgtcggg ccccccgggg aggcggctgt     1440

ggggctgctc cagttcaatc tcagcgagct gttcagttgg tggattcgcc aaggcgaagg     1500

gcgactgagg atccgcctga tgcccgagaa gaaggcgtcg gaagtgggca gagagggaag     1560

gctgtccgcg gcaattcgcg cctcccagcc ccgccttctc ttccagatct tcgggactgg     1620

tcatagctcc ttggaatcac caacaaacat gccttctcct tctcctgatt attttacatg     1680

gaatctcacc tggataatga aagactcctt ccctttcctg tctcatcgca gccgatatgg     1740

tctggagtgc agctttgact tcccctgtga gctggagtat tcccctccac tgcatgacct     1800

caggaaccag agctggtcct ggcgccgcat cccctccgag gaggcctccc agatggactt     1860

gctggatggg cctggggcag agcgttctaa ggagatgccc agaggctcct ttctccttct     1920

caacacctca gctgactcca agcacaccat cctgagtccg tggatgagga gcagcagtga     1980

gcactgcaca ctggccgtct cggtgcacag gcacctgcag ccctctggaa ggtacattgc     2040

ccagctgctg ccccacaacg aggctgcaag agagatcctc ctgatgccca ctccagggaa     2100

gcatggttgg acagtgctcc agggaagaat cgggcgtcca gacaacccat ttcgagtggc     2160

cctggaatac atctccagtg gaaaccgcag cttgtctgca gtggacttct ttgccctgaa     2220

gaactgcagt gaaggaacat ccccaggctc caagatggcc ctgcagagct ccttcacttg     2280

ttggaatggg acagtcctcc agcttgggca ggcctgtgac ttccaccagg actgtgccca     2340

gggagaagat gagagccaga tgtgccggaa actgcctgtg ggtttttact gcaactttga     2400

agatggcttc tgtggctgga cccaaggcac actgtcaccc cacactcctc aatggcaggt     2460

caggacccta aaggatgccc ggttccagga ccaccaagac catgctctat tgctcagtac     2520

cactgatgtc cccgcttctg aaagtgctac agtgaccagt gctacgtttc ctgcaccgat     2580

caagagctct ccatgtgagc tccgaatgtc ctggctcatt cgtggagtct tgaggggaaa     2640

cgtgtccttg gtgctagtgg agaacaaaac cgggaaggag caaggcagga tggtctggca     2700

tgtcgccgcc tatgaaggct tgagcctgtg gcagtggatg gtgttgcctc tcctcgatgt     2760

gtctgacagg ttctggctgc agatggtcgc atggtgggga caaggatcca gagccatcgt     2820

ggcttttgac aatatctcca tcagcctgga ctgctacctc accattagcg gagaggacaa     2880

gatcctgcag aatacagcac ccaaatcaag aaacctgttt gagagaaacc caaacaagga     2940

gctgaaaccc ggggaaaatt caccaagaca gacccccatc tttgacccta cagttcattg     3000

gctgttcacc acatgtgggg ccagcgggcc ccatggcccc acccaggcac agtgcaacaa     3060

cgcctaccag aactccaacc tgagcgtgga ggtggggagc gagggccccc tgaaaggcat     3120

ccagatctgg aaggtgccag ccaccgacac ctacagcatc tcgggctacg gagctgctgg     3180

cgggaaaggc gggaagaaca ccatgatgcg gtcccacggc gtgtctgtgc tgggcatctt     3240

caacctggag aaggatgaca tgctgtacat cctggttggg cagcagggag aggacgcctg     3300

ccccagtaca aaccagttaa tccagaaagt ctgcattgga gagaacaatg tgatagaaga     3360

agaaatccgt gtgaacagaa gcgtgcatga gtgggcagga ggcggaggag gagggggtgg     3420

agccacctac gtatttaaga tgaaggatgg agtgccggtg cccctgatca ttgcagccgg     3480

aggtggtggc agggcctacg gggccaagac agacacgttc cacccagaga gactggagaa     3540

taactcctcg gttctagggc taaacggcaa ttccggagcc gcaggtggtg gaggtggctg     3600

gaatgataac acttccttgc tctgggccgg aaaatctttg caggagggtg ccaccggagg     3660

acattcctgc ccccaggcca tgaagaagtg ggggtgggag acaagagggg gtttcggagg     3720

gggtggaggg gggtgctcct caggtggagg aggcggagga tatataggcg gcaatgcagc     3780

ctcaaacaat gaccccgaaa tggatgggga agatggggtt tccttcatca gtccactggg     3840

catcctgtac accccagctt taaaagtgat ggaaggccac ggggaagtga atattaagca     3900

ttatctaaac tgcagtcact gtgaggtaga cgaatgtcac atggaccctg aaagccacaa     3960

ggtcatctgc ttctgtgacc acgggacggt gctggctgag gatggcgtct cctgcattgt     4020

gtcacccacc ccggagccac acctgccact ctcgctgatc ctctctgtgg tgacctctgc     4080

cctcgtggcc gccctggtcc tggctttctc cggcatcatg attgtgtacc gccggaagca     4140

ccaggagctg caagccatgc agatggagct gcagagccct gagtacaagc tgagcaagct     4200

ccgcacctcg accatcatga ccgactacaa ccccaactac tgctttgctg gcaagacctc     4260

ctccatcagt gacctgaagg aggtgccgcg gaaaaacatc accctcattc ggggtctggg     4320

ccatggcgcc tttggggagg tgtatgaagg ccaggtgtcc ggaatgccca acgacccaag     4380

ccccctgcaa gtggctgtga agacgctgcc tgaagtgtgc tctgaacagg acgaactgga     4440

tttcctcatg gaagccctga tcatcagcaa attcaaccac cagaacattg ttcgctgcat     4500

tggggtgagc ctgcaatccc tgccccggtt catcctgctg gagctcatgg cggggggaga     4560

cctcaagtcc ttcctccgag agacccgccc tcgcccgagc cagccctcct ccctggccat     4620

gctggacctt ctgcacgtgg ctcgggacat tgcctgtggc tgtcagtatt tggaggaaaa     4680

ccacttcatc caccgagaca ttgctgccag aaactgcctc ttgacctgtc caggccctgg     4740

aagagtggcc aagattggag acttcgggat ggcccgagac atctacaggg cgagctacta     4800

tagaaaggga ggctgtgcca tgctgccagt taagtggatg cccccagagg ccttcatgga     4860

aggaatattc acttctaaaa cagacacatg gtcctttgga gtgctgctat gggaaatctt     4920

ttctcttgga tatatgccat accccagcaa aagcaaccag gaagttctgg agtttgtcac     4980

cagtggaggc cggatggacc cacccaagaa ctgccctggg cctgtatacc ggataatgac     5040

tcagtgctgg caacatcagc ctgaagacag gcccaacttt gccatcattt tggagaggat     5100

tgaatactgc acccaggacc cggatgtaat caacaccgct ttgccgatag aatatggtcc     5160

acttgtggaa gaggaagaga aagtgcctgt gaggcccaag gaccctgagg gggttcctcc     5220

tctcctggtc tctcaacagg caaaacggga ggaggagcgc agcccagctg ccccaccacc     5280

tctgcctacc acctcctctg gcaaggctgc aaagaaaccc acagctgcag agatctctgt     5340

tcgagtccct agagggccgg ccgtggaagg gggacacgtg aatatggcat tctctcagtc     5400

caaccctcct tcggagttgc acaaggtcca cggatccaga aacaagccca ccagcttgtg     5460

gaacccaacg tacggctcct ggtttacaga gaaacccacc aaaaagaata atcctatagc     5520

aaagaaggag ccacacgaca ggggtaacct ggggctggag ggaagctgta ctgtcccacc     5580

taacgttgca actgggagac ttccgggggc ctcactgctc ctagagccct cttcgctgac     5640

tgccaatatg aaggaggtac ctctgttcag gctacgtcac ttcccttgtg ggaatgtcaa     5700

ttacggctac cagcaacagg gcttgccctt agaagccgct actgcccctg gagctggtca     5760

ttacgaggat accattctga aaagcaagaa tagcatgaac cagcctgggc cctgagctcg     5820

gtcgcacact cacttctctt ccttgggatc cctaagaccg tggaggagag agaggcaatg     5880

gctccttcac aaaccagaga ccaaatgtca cgttttgttt tgtgccaacc tattttgaag     5940

taccaccaaa aaagctgtat tttgaaaatg ctttagaaag gttttgagca tgggttcatc     6000

ctattctttc gaaagaagaa aatatcataa aaatgagtga taaatacaag gcccagatgt     6060

ggttgcataa ggtttttatg catgtttgtt gtatacttcc ttatgcttct ttcaaattgt     6120

gtgtgctctg cttcaatgta gtcagaatta gctgcttcta tgtttcatag ttggggtcat     6180

agatgtttcc ttgccttgtt gatgtggaca tgagccattt gaggggagag ggaacggaaa     6240

taaaggagtt atttgtaatg actaaaa                                         6267


<210>  11
<211>  2933
<212>  DNA
<213>  Homo sapiens

<400>  11
agccgcgcgc cggccacccg cgcgcctgcc gcccgttgcc caggcaaccg tcgtgccgcg       60

tcttcctgag gtagctcctg tcagcccact gatcccacca cccgctccct actgccccgc      120

ggtcttcgcg tgagctcgga gactgaggga caacaaaaat ggcggagggg agccagtcgg      180

cgcctgaggc aggcaatgat atgggaaatg atgatgccat tggagggaat gtgagcaaat      240

atatagtgct tccaactggc tattgtggac agcccaagaa aggacatctt atctttgatg      300

cttgctttga aagtggtaac ctgggccggg tggaccaggt ctctgagttt gagtatgatc      360

tgttcattag gccggacacc tgtaatccac gcttccgagt ctggttcaac tttactgttg      420

aaaatgtgaa agaatcacag agggtcattt tcaacattgt taacttcagt aaaaccaaga      480

gtctctatag agatgggatg gcccctatgg tgaaatctac cagcagacca aaatggcaaa      540

ggctgccacc caaaaatgtt tactactacc gctgcccgga ccataggaag aactatgtga      600

tgtcctttgc cttttgtttt gaccgagaag aagatattta ccagtttgct tactgctacc      660

catatacata cactcgcttc caacattacc ttgacagcct gcaaaagaga aacatggatt      720

acttctttcg ggagcagctg ggccagagtg tgcaacaacg aaagcttgac ctcctgacga      780

taaccagccc tgtgtaccgc cggaagcacc aggagctgca agccatgcag atggagctgc      840

agagccctga gtacaagctg agcaagctcc gcacctcgac catcatgacc gactacaacc      900

ccaactactg ctttgctggc aagacctcct ccatcagtga cctgaaggag gtgccgcgga      960

aaaacatcac cctcattcgg ggtctgggcc atggcgcctt tggggaggtg tatgaaggcc     1020

aggtgtccgg aatgcccaac gacccaagcc ccctgcaagt ggctgtgaag acgctgcctg     1080

aagtgtgctc tgaacaggac gaactggatt tcctcatgga agccctgatc atcagcaaat     1140

tcaaccacca gaacattgtt cgctgcattg gggtgagcct gcaatccctg ccccggttca     1200

tcctgctgga gctcatggcg gggggagacc tcaagtcctt cctccgagag acccgccctc     1260

gcccgagcca gccctcctcc ctggccatgc tggaccttct gcacgtggct cgggacattg     1320

cctgtggctg tcagtatttg gaggaaaacc acttcatcca ccgagacatt gctgccagaa     1380

actgcctctt gacctgtcca ggccctggaa gagtggccaa gattggagac ttcgggatgg     1440

cccgagacat ctacagggcg agctactata gaaagggagg ctgtgccatg ctgccagtta     1500

agtggatgcc cccagaggcc ttcatggaag gaatattcac ttctaaaaca gacacatggt     1560

cctttggagt gctgctatgg gaaatctttt ctcttggata tatgccatac cccagcaaaa     1620

gcaaccagga agttctggag tttgtcacca gtggaggccg gatggaccca cccaagaact     1680

gccctgggcc tgtataccgg ataatgactc agtgctggca acatcagcct gaagacaggc     1740

ccaactttgc catcattttg gagaggattg aatactgcac ccaggacccg gatgtaatca     1800

acaccgcttt gccgatagaa tatggtccac ttgtggaaga ggaagagaaa gtgcctgtga     1860

ggcccaagga ccctgagggg gttcctcctc tcctggtctc tcaacaggca aaacgggagg     1920

aggagcgcag cccagctgcc ccaccacctc tgcctaccac ctcctctggc aaggctgcaa     1980

agaaacccac agctgcagag atctctgttc gagtccctag agggccggcc gtggaagggg     2040

gacacgtgaa tatggcattc tctcagtcca accctccttc ggagttgcac aaggtccacg     2100

gatccagaaa caagcccacc agcttgtgga acccaacgta cggctcctgg tttacagaga     2160

aacccaccaa aaagaataat cctatagcaa agaaggagcc acacgacagg ggtaacctgg     2220

ggctggaggg aagctgtact gtcccaccta acgttgcaac tgggagactt ccgggggcct     2280

cactgctcct agagccctct tcgctgactg ccaatatgaa ggaggtacct ctgttcaggc     2340

tacgtcactt cccttgtggg aatgtcaatt acggctacca gcaacagggc ttgcccttag     2400

aagccgctac tgcccctgga gctggtcatt acgaggatac cattctgaaa agcaagaata     2460

gcatgaacca gcctgggccc tgagctcggt cgcacactca cttctcttcc ttgggatccc     2520

taagaccgtg gaggagagag aggcaatggc tccttcacaa accagagacc aaatgtcacg     2580

ttttgttttg tgccaaccta ttttgaagta ccaccaaaaa agctgtattt tgaaaatgct     2640

ttagaaaggt tttgagcatg ggttcatcct attctttcga aagaagaaaa tatcataaaa     2700

atgagtgata aatacaaggc ccagatgtgg ttgcataagg tttttatgca tgtttgttgt     2760

atacttcctt atgcttcttt caaattgtgt gtgctctgct tcaatgtagt cagaattagc     2820

tgcttctatg tttcatagtt ggggtcatag atgtttcctt gccttgttga tgtggacatg     2880

agccatttga ggggagaggg aacggaaata aaggagttat ttgtaatgac taa            2933


<210>  12
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Glu Gly Ser Gln Ser Ala Pro Glu Ala Gly Asn Asp Met Gly 
1               5                   10                  15      


Asn Asp Asp Ala Ile Gly Gly Asn Val Ser Lys Tyr Ile Val Leu Pro 
            20                  25                  30          


Thr Gly Tyr Cys Gly Gln Pro Lys Lys Gly His Leu Ile Phe Asp Ala 
        35                  40                  45              


Cys Phe Glu Ser Gly Asn Leu Gly Arg Val Asp Gln Val Ser Glu Phe 
    50                  55                  60                  


Glu Tyr Asp Leu Phe Ile Arg Pro Asp Thr Cys Asn Pro Arg Phe Arg 
65                  70                  75                  80  


Val Trp Phe Asn Phe Thr Val Glu Asn Val Lys Glu Ser Gln Arg Val 
                85                  90                  95      


Ile Phe Asn Ile Val Asn Phe Ser Lys Thr Lys Ser Leu Tyr Arg Asp 
            100                 105                 110         


Gly Met Ala Pro Met Val Lys Ser Thr Ser Arg Pro Lys Trp Gln Arg 
        115                 120                 125             


Leu Pro Pro Lys Asn Val Tyr Tyr Tyr Arg Cys Pro Asp His Arg Lys 
    130                 135                 140                 


Asn Tyr Val Met Ser Phe Ala Phe Cys Phe Asp Arg Glu Glu Asp Ile 
145                 150                 155                 160 


Tyr Gln Phe Ala Tyr Cys Tyr Pro Tyr Thr Tyr Thr Arg Phe Gln His 
                165                 170                 175     


Tyr Leu Asp Ser Leu Gln Lys Arg Asn Met Asp Tyr Phe Phe Arg Glu 
            180                 185                 190         


Gln Leu Gly Gln Ser Val Gln Gln Arg Lys Leu Asp Leu Leu Thr Ile 
        195                 200                 205             


Thr Ser Pro Val Tyr Arg Arg Lys His Gln Glu Leu Gln Ala Met Gln 
    210                 215                 220                 


Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser Lys Leu Arg Thr Ser 
225                 230                 235                 240 


Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys Phe Ala Gly Lys Thr 
                245                 250                 255     


Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg Lys Asn Ile Thr Leu 
            260                 265                 270         


Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Gln 
        275                 280                 285             


Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu Gln Val Ala Val Lys 
    290                 295                 300                 


Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu Leu Asp Phe Leu Met 
305                 310                 315                 320 


Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln Asn Ile Val Arg Cys 
                325                 330                 335     


Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe Ile Leu Leu Glu Leu 
            340                 345                 350         


Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg Glu Thr Arg Pro Arg 
        355                 360                 365             


Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp Leu Leu His Val Ala 
    370                 375                 380                 


Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu Glu Asn His Phe Ile 
385                 390                 395                 400 


His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Thr Cys Pro Gly Pro 
                405                 410                 415     


Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr 
            420                 425                 430         


Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala Met Leu Pro Val Lys 
        435                 440                 445             


Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile Phe Thr Ser Lys Thr 
    450                 455                 460                 


Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly 
465                 470                 475                 480 


Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu Val Leu Glu Phe Val 
                485                 490                 495     


Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn Cys Pro Gly Pro Val 
            500                 505                 510         


Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln Pro Glu Asp Arg Pro 
        515                 520                 525             


Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr Cys Thr Gln Asp Pro 
    530                 535                 540                 


Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr Gly Pro Leu Val Glu 
545                 550                 555                 560 


Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp Pro Glu Gly Val Pro 
                565                 570                 575     


Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu Glu Glu Arg Ser Pro 
            580                 585                 590         


Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser Gly Lys Ala Ala Lys 
        595                 600                 605             


Lys Pro Thr Ala Ala Glu Ile Ser Val Arg Val Pro Arg Gly Pro Ala 
    610                 615                 620                 


Val Glu Gly Gly His Val Asn Met Ala Phe Ser Gln Ser Asn Pro Pro 
625                 630                 635                 640 


Ser Glu Leu His Lys Val His Gly Ser Arg Asn Lys Pro Thr Ser Leu 
                645                 650                 655     


Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu Lys Pro Thr Lys Lys 
            660                 665                 670         


Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp Arg Gly Asn Leu Gly 
        675                 680                 685             


Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val Ala Thr Gly Arg Leu 
    690                 695                 700                 


Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser Leu Thr Ala Asn Met 
705                 710                 715                 720 


Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe Pro Cys Gly Asn Val 
                725                 730                 735     


Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu Glu Ala Ala Thr Ala 
            740                 745                 750         


Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu Lys Ser Lys Asn Ser 
        755                 760                 765             


Met Asn Gln Pro Gly Pro 
    770                 


<210>  13
<211>  2930
<212>  DNA
<213>  Homo sapiens

<400>  13
cgcgggctga gctgcccgac cggggcccgc ccccggcgcc caccatgtac gcctttgtgc       60

ggttcctgga ggacaacgtc tgctacgcgc tgcccgtgtc gtgcgtgcgc gacttcagcc      120

cccgctcgcg gctggatttt gacaaccaga aggtgtacgc cgtgtaccgg ggcccggagg      180

aattgggcgc cgggcccgag agccccccgc gcgccccccg cgactggggc gcgctgttgc      240

tccacaaggc ccagatcctg gcgctggcag aagacaaatc tgaccttgaa aacagtgtga      300

tgcagaagaa aataaaaatc cccaagcttt ctcttaatca tgtagaagaa gatggagagg      360

ttaaagatta tggggaagaa gatttacagc ttagacacat caagagacct gaggggcgga      420

agccgagcga agtggcgcac aagagcatcg aggcagtggt ggctcggcta gagaagcaga      480

acggcctgag cctgggccat agcacgtgtc cggaagaggt cttcgtggag gcctcgccag      540

gcacagagga catggacagt ctagaagatg ctgtggtgcc ccgggctctg tatgaggagc      600

tgctgcgcaa ctaccagcag caacaggaag agatgcgcca cctccagcag gagctggagc      660

ggactcggag gcagctggta caacaggcca agaagctcaa ggagtacggg gcacttgtgt      720

ctgaaatgaa ggagctccgt gaccttaacc ggaggctcca ggacgtgctg ctcctgcggc      780

ttggcagcgt gtaccgccgg aagcaccagg agctgcaagc catgcagatg gagctgcaga      840

gccctgagta caagctgagc aagctccgca cctcgaccat catgaccgac tacaacccca      900

actactgctt tgctggcaag acctcctcca tcagtgacct gaaggaggtg ccgcggaaaa      960

acatcaccct cattcggggt ctgggccatg gcgcctttgg ggaggtgtat gaaggccagg     1020

tgtccggaat gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg ctgcctgaag     1080

tgtgctctga acaggacgaa ctggatttcc tcatggaagc cctgatcatc agcaaattca     1140

accaccagaa cattgttcgc tgcattgggg tgagcctgca atccctgccc cggttcatcc     1200

tgctggagct catggcgggg ggagacctca agtccttcct ccgagagacc cgccctcgcc     1260

cgagccagcc ctcctccctg gccatgctgg accttctgca cgtggctcgg gacattgcct     1320

gtggctgtca gtatttggag gaaaaccact tcatccaccg agacattgct gccagaaact     1380

gcctcttgac ctgtccaggc cctggaagag tggccaagat tggagacttc gggatggccc     1440

gagacatcta cagggcgagc tactatagaa agggaggctg tgccatgctg ccagttaagt     1500

ggatgccccc agaggccttc atggaaggaa tattcacttc taaaacagac acatggtcct     1560

ttggagtgct gctatgggaa atcttttctc ttggatatat gccatacccc agcaaaagca     1620

accaggaagt tctggagttt gtcaccagtg gaggccggat ggacccaccc aagaactgcc     1680

ctgggcctgt ataccggata atgactcagt gctggcaaca tcagcctgaa gacaggccca     1740

actttgccat cattttggag aggattgaat actgcaccca ggacccggat gtaatcaaca     1800

ccgctttgcc gatagaatat ggtccacttg tggaagagga agagaaagtg cctgtgaggc     1860

ccaaggaccc tgagggggtt cctcctctcc tggtctctca acaggcaaaa cgggaggagg     1920

agcgcagccc agctgcccca ccacctctgc ctaccacctc ctctggcaag gctgcaaaga     1980

aacccacagc tgcagagatc tctgttcgag tccctagagg gccggccgtg gaagggggac     2040

acgtgaatat ggcattctct cagtccaacc ctccttcgga gttgcacaag gtccacggat     2100

ccagaaacaa gcccaccagc ttgtggaacc caacgtacgg ctcctggttt acagagaaac     2160

ccaccaaaaa gaataatcct atagcaaaga aggagccaca cgacaggggt aacctggggc     2220

tggagggaag ctgtactgtc ccacctaacg ttgcaactgg gagacttccg ggggcctcac     2280

tgctcctaga gccctcttcg ctgactgcca atatgaagga ggtacctctg ttcaggctac     2340

gtcacttccc ttgtgggaat gtcaattacg gctaccagca acagggcttg cccttagaag     2400

ccgctactgc ccctggagct ggtcattacg aggataccat tctgaaaagc aagaatagca     2460

tgaaccagcc tgggccctga gctcggtcgc acactcactt ctcttccttg ggatccctaa     2520

gaccgtggag gagagagagg caatggctcc ttcacaaacc agagaccaaa tgtcacgttt     2580

tgttttgtgc caacctattt tgaagtacca ccaaaaaagc tgtattttga aaatgcttta     2640

gaaaggtttt gagcatgggt tcatcctatt ctttcgaaag aagaaaatat cataaaaatg     2700

agtgataaat acaaggccca gatgtggttg cataaggttt ttatgcatgt ttgttgtata     2760

cttccttatg cttctttcaa attgtgtgtg ctctgcttca atgtagtcag aattagctgc     2820

ttctatgttt catagttggg gtcatagatg tttccttgcc ttgttgatgt ggacatgagc     2880

catttgaggg gagagggaac ggaaataaag gagttatttg taatgactaa                2930


<210>  14
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Tyr Ala Phe Val Arg Phe Leu Glu Asp Asn Val Cys Tyr Ala Leu 
1               5                   10                  15      


Pro Val Ser Cys Val Arg Asp Phe Ser Pro Arg Ser Arg Leu Asp Phe 
            20                  25                  30          


Asp Asn Gln Lys Val Tyr Ala Val Tyr Arg Gly Pro Glu Glu Leu Gly 
        35                  40                  45              


Ala Gly Pro Glu Ser Pro Pro Arg Ala Pro Arg Asp Trp Gly Ala Leu 
    50                  55                  60                  


Leu Leu His Lys Ala Gln Ile Leu Ala Leu Ala Glu Asp Lys Ser Asp 
65                  70                  75                  80  


Leu Glu Asn Ser Val Met Gln Lys Lys Ile Lys Ile Pro Lys Leu Ser 
                85                  90                  95      


Leu Asn His Val Glu Glu Asp Gly Glu Val Lys Asp Tyr Gly Glu Glu 
            100                 105                 110         


Asp Leu Gln Leu Arg His Ile Lys Arg Pro Glu Gly Arg Lys Pro Ser 
        115                 120                 125             


Glu Val Ala His Lys Ser Ile Glu Ala Val Val Ala Arg Leu Glu Lys 
    130                 135                 140                 


Gln Asn Gly Leu Ser Leu Gly His Ser Thr Cys Pro Glu Glu Val Phe 
145                 150                 155                 160 


Val Glu Ala Ser Pro Gly Thr Glu Asp Met Asp Ser Leu Glu Asp Ala 
                165                 170                 175     


Val Val Pro Arg Ala Leu Tyr Glu Glu Leu Leu Arg Asn Tyr Gln Gln 
            180                 185                 190         


Gln Gln Glu Glu Met Arg His Leu Gln Gln Glu Leu Glu Arg Thr Arg 
        195                 200                 205             


Arg Gln Leu Val Gln Gln Ala Lys Lys Leu Lys Glu Tyr Gly Ala Leu 
    210                 215                 220                 


Val Ser Glu Met Lys Glu Leu Arg Asp Leu Asn Arg Arg Leu Gln Asp 
225                 230                 235                 240 


Val Leu Leu Leu Arg Leu Gly Ser Val Tyr Arg Arg Lys His Gln Glu 
                245                 250                 255     


Leu Gln Ala Met Gln Met Glu Leu Gln Ser Pro Glu Tyr Lys Leu Ser 
            260                 265                 270         


Lys Leu Arg Thr Ser Thr Ile Met Thr Asp Tyr Asn Pro Asn Tyr Cys 
        275                 280                 285             


Phe Ala Gly Lys Thr Ser Ser Ile Ser Asp Leu Lys Glu Val Pro Arg 
    290                 295                 300                 


Lys Asn Ile Thr Leu Ile Arg Gly Leu Gly His Gly Ala Phe Gly Glu 
305                 310                 315                 320 


Val Tyr Glu Gly Gln Val Ser Gly Met Pro Asn Asp Pro Ser Pro Leu 
                325                 330                 335     


Gln Val Ala Val Lys Thr Leu Pro Glu Val Cys Ser Glu Gln Asp Glu 
            340                 345                 350         


Leu Asp Phe Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Asn His Gln 
        355                 360                 365             


Asn Ile Val Arg Cys Ile Gly Val Ser Leu Gln Ser Leu Pro Arg Phe 
    370                 375                 380                 


Ile Leu Leu Glu Leu Met Ala Gly Gly Asp Leu Lys Ser Phe Leu Arg 
385                 390                 395                 400 


Glu Thr Arg Pro Arg Pro Ser Gln Pro Ser Ser Leu Ala Met Leu Asp 
                405                 410                 415     


Leu Leu His Val Ala Arg Asp Ile Ala Cys Gly Cys Gln Tyr Leu Glu 
            420                 425                 430         


Glu Asn His Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu 
        435                 440                 445             


Thr Cys Pro Gly Pro Gly Arg Val Ala Lys Ile Gly Asp Phe Gly Met 
    450                 455                 460                 


Ala Arg Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys Gly Gly Cys Ala 
465                 470                 475                 480 


Met Leu Pro Val Lys Trp Met Pro Pro Glu Ala Phe Met Glu Gly Ile 
                485                 490                 495     


Phe Thr Ser Lys Thr Asp Thr Trp Ser Phe Gly Val Leu Leu Trp Glu 
            500                 505                 510         


Ile Phe Ser Leu Gly Tyr Met Pro Tyr Pro Ser Lys Ser Asn Gln Glu 
        515                 520                 525             


Val Leu Glu Phe Val Thr Ser Gly Gly Arg Met Asp Pro Pro Lys Asn 
    530                 535                 540                 


Cys Pro Gly Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Gln 
545                 550                 555                 560 


Pro Glu Asp Arg Pro Asn Phe Ala Ile Ile Leu Glu Arg Ile Glu Tyr 
                565                 570                 575     


Cys Thr Gln Asp Pro Asp Val Ile Asn Thr Ala Leu Pro Ile Glu Tyr 
            580                 585                 590         


Gly Pro Leu Val Glu Glu Glu Glu Lys Val Pro Val Arg Pro Lys Asp 
        595                 600                 605             


Pro Glu Gly Val Pro Pro Leu Leu Val Ser Gln Gln Ala Lys Arg Glu 
    610                 615                 620                 


Glu Glu Arg Ser Pro Ala Ala Pro Pro Pro Leu Pro Thr Thr Ser Ser 
625                 630                 635                 640 


Gly Lys Ala Ala Lys Lys Pro Thr Ala Ala Glu Ile Ser Val Arg Val 
                645                 650                 655     


Pro Arg Gly Pro Ala Val Glu Gly Gly His Val Asn Met Ala Phe Ser 
            660                 665                 670         


Gln Ser Asn Pro Pro Ser Glu Leu His Lys Val His Gly Ser Arg Asn 
        675                 680                 685             


Lys Pro Thr Ser Leu Trp Asn Pro Thr Tyr Gly Ser Trp Phe Thr Glu 
    690                 695                 700                 


Lys Pro Thr Lys Lys Asn Asn Pro Ile Ala Lys Lys Glu Pro His Asp 
705                 710                 715                 720 


Arg Gly Asn Leu Gly Leu Glu Gly Ser Cys Thr Val Pro Pro Asn Val 
                725                 730                 735     


Ala Thr Gly Arg Leu Pro Gly Ala Ser Leu Leu Leu Glu Pro Ser Ser 
            740                 745                 750         


Leu Thr Ala Asn Met Lys Glu Val Pro Leu Phe Arg Leu Arg His Phe 
        755                 760                 765             


Pro Cys Gly Asn Val Asn Tyr Gly Tyr Gln Gln Gln Gly Leu Pro Leu 
    770                 775                 780                 


Glu Ala Ala Thr Ala Pro Gly Ala Gly His Tyr Glu Asp Thr Ile Leu 
785                 790                 795                 800 


Lys Ser Lys Asn Ser Met Asn Gln Pro Gly Pro 
                805                 810     


<210>  15
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  16
<211>  2613
<212>  DNA
<213>  Homo sapiens

<400>  16
gtcatctgtc tggacgcgct gggtggatgc ggggggctcc tgggaactgt gttggagccg       60

agcaagcgct agccaggcgc aagcgcgcac agactgtagc catccgagga cacccccgcc      120

cccccggccc acccggagac acccgcgcag aatcgcctcc ggatcccctg cagtcggcgg      180

gagtgttgga ggtcggcgcc ggcccccgcc ttccgcgccc cccacgggaa ggaagcaccc      240

ccggtattaa aacgaacggg gcggaaagaa gccctcagtc gccggccggg aggcgagccg      300

atgccgagct gctccacgtc caccatgccg ggcatgatct gcaagaaccc agacctcgag      360

tttgactcgc tacagccctg cttctacccg gacgaagatg acttctactt cggcggcccc      420

gactcgaccc ccccggggga ggacatctgg aagaagtttg agctgctgcc cacgcccccg      480

ctgtcgccca gccgtggctt cgcggagcac agctccgagc ccccgagctg ggtcacggag      540

atgctgcttg agaacgagct gtggggcagc ccggccgagg aggacgcgtt cggcctgggg      600

ggactgggtg gcctcacccc caacccggtc atcctccagg actgcatgtg gagcggcttc      660

tccgcccgcg agaagctgga gcgcgccgtg agcgagaagc tgcagcacgg ccgcgggccg      720

ccaaccgccg gttccaccgc ccagtccccg ggagccggcg ccgccagccc tgcgggtcgc      780

gggcacggcg gggctgcggg agccggccgc gccggggccg ccctgcccgc cgagctcgcc      840

cacccggccg ccgagtgcgt ggatcccgcc gtggtcttcc cctttcccgt gaacaagcgc      900

gagccagcgc ccgtgcccgc agccccggcc agtgccccgg cggcgggccc tgcggtcgcc      960

tcgggggcgg gtattgccgc cccagccggg gccccggggg tcgcccctcc gcgcccaggc     1020

ggccgccaga ccagcggcgg cgaccacaag gccctcagta cctccggaga ggacaccctg     1080

agcgattcag atgatgaaga tgatgaagag gaagatgaag aggaagaaat cgacgtggtc     1140

actgtggaga agcggcgttc ctcctccaac accaaggctg tcaccacatt caccatcact     1200

gtgcgtccca agaacgcagc cctgggtccc gggagggctc agtccagcga gctgatcctc     1260

aaacgatgcc ttcccatcca ccagcagcac aactatgccg ccccctctcc ctacgtggag     1320

agtgaggatg cacccccaca gaagaagata aagagcgagg cgtccccacg tccgctcaag     1380

agtgtcatcc ccccaaaggc taagagcttg agcccccgaa actctgactc ggaggacagt     1440

gagcgtcgca gaaaccacaa catcctggag cgccagcgcc gcaacgacct tcggtccagc     1500

tttctcacgc tcagggacca cgtgccggag ttggtaaaga atgagaaggc cgccaaggtg     1560

gtcattttga aaaaggccac tgagtatgtc cactccctcc aggccgagga gcaccagctt     1620

ttgctggaaa aggaaaaatt gcaggcaaga cagcagcagt tgctaaagaa aattgaacac     1680

gctcggactt gctagacgct tctcaaaact ggacagtcac tgccactttg cacattttga     1740

tttttttttt aaacaaacat tgtgttgaca ttaagaatgt tggtttactt tcaaatcggt     1800

cccctgtcga gttcggctct gggtgggcag taggaccacc agtgtggggt tctgctggga     1860

ccttggagag cctgcatccc aggatgctgg gtggccctgc agcctcctcc acctcacctc     1920

catgacagcg ctaaacgttg gtgacggttg ggagcctctg gggctgttga agtcaccttg     1980

tgtgttccaa gtttccaaac aacagaaagt cattccttct ttttaaaatg gtgcttaagt     2040

tccagcagat gccacataag gggtttgcca tttgataccc ctggggaaca tttctgtaaa     2100

taccattgac acatccgcct tttgtataca tcctgggtaa tgagaggtgg cttttgcggc     2160

cagtattaga ctggaagttc atacctaagt actgtaataa tacctcaatg tttgaggagc     2220

atgttttgta tacaaatata ttgttaatct ctgttatgta ctgtactaat tcttacactg     2280

cctgtatact ttagtatgac gctgatacat aactaaattt gatacttata ttttcgtatg     2340

aaaatgagtt gtgaaagttt tgagtagata ttactttatc actttttgaa ctaagaaact     2400

tttgtaaaga aatttactat atatatatgc ctttttccta gcctgtttct tcctgttaat     2460

gtatttgttc atgtttggtg catagaactg ggtaaatgca aagttctgtg tttaatttct     2520

tcaaaatgta tatatttagt gctgcatctt atagcacttt gaaatacctc atgtttatga     2580

aaataaatag cttaaaatta aatgaaaaaa aaa                                  2613


