                         SEQUENCE LISTING

<110>  Delenex Therapeutics AG
 
<120>  Binding members to IL-1 beta

<130>  P109026PC01

<150>  PCT/EP2013/073009
<151>  2013-11-05

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 sequence

<400>  1

Phe Ser Leu Ser Asn Ser Ala Met Ala 
1               5                   


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 sequence

<400>  2

Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 sequence

<400>  3

Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 sequence

<400>  4

Arg Ala Ser Gln Ser Ile Gly Asn Trp Leu Ser 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 sequence

<400>  5

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 sequence

<400>  6

Gln Asn Thr Gly Gly Gly Ile Asn Ile Ala 
1               5                   10  


<210>  7
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L1

<400>  7

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys 
            20              


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L2

<400>  8

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  9
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L3

<400>  9

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L4

<400>  10

Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  11
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H1

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25      


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H2

<400>  12

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H3

<400>  13

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H4

<400>  14

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H1

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
            20                  25      


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H2

<400>  16

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H3

<400>  17

Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H4

<400>  18

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-L3

<400>  19

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  20
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H1

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asn Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly 
            20                  25      


<210>  21
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-H3

<400>  21

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  22
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain

<400>  22

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile Asn 
                85                  90                  95      


Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  23
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain

<400>  23

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile 
                85                  90                  95      


Asn Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  24
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asn Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Asn Ser 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  26
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain

<400>  26

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile Asn 
                85                  90                  95      


Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain

<400>  27

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile 
                85                  90                  95      


Asn Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  28
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Ser 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  29
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single chain variable fragment

<400>  29

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile Asn 
                85                  90                  95      


Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asn Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Asn 
145                 150                 155                 160 


Ser Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  30
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single chain variable fragment

<400>  30

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile 
                85                  90                  95      


Asn Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asn Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Asn Ser Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  31
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single chain variable fragment

<400>  31

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile Asn 
                85                  90                  95      


Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn 
145                 150                 155                 160 


Ser Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Lys Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  32
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single chain variable fragment

<400>  32

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile 
                85                  90                  95      


Asn Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Asn Ser Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Lys Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  33
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv1

<400>  33

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Val 
                85                  90                  95      


Ser Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Ser Ala Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Val Leu Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  34
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain

<400>  34

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Val Ser 
                85                  90                  95      


Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  35
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain

<400>  35

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Val 
                85                  90                  95      


Ser Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  36
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single chain variable fragment

<400>  36

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Val Ser 
                85                  90                  95      


Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asn Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Asn 
145                 150                 155                 160 


Ser Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp Ala 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  37
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv4 with N-terminal M

<400>  37

Met Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Val 
                85                  90                  95      


Ser Ile Ala Phe Gly Gln Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asn Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Asn Ser Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  38
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG-scFv2 LC

<400>  38

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Thr Gly Gly Gly Ile Asn 
                85                  90                  95      


Ile Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  39
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG-scFv2 HC

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Asn Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Asn Ser 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Asp Ser Ala Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Ala Ile Phe Ser Gly Asp Phe Ala Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


