                         SEQUENCE LISTING

<110>  Deciphera Pharmaceuticals, LLC
       Flynn, Daniel
       Kaufman, Michael
       Smith, Brian
       Rudoltz, Marc
 
<120>  METHODS FOR INHIBITING TIE2 KINASE USEFUL IN THE TREATMENT OF 
       CANCER

<130>  DECP-066/00WO 313114-2322

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala Phe Gln 
1               5                   10                  15      


Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr Leu Ala 
            20                  25                  30          


Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr Pro Val 
        35                  40                  45              


Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu Gly Asn 
    50                  55                  60                  


Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu Arg Met 
65                  70                  75                  80  


Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp Asp His 
                85                  90                  95      


Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly His His 
            100                 105                 110         


Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly Tyr Leu 
        115                 120                 125             


Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp Phe Leu 
    130                 135                 140                 


Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile Ala Asn 
145                 150                 155                 160 


Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe Ala Ala 
                165                 170                 175     


Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe Ile His 
            180                 185                 190         


Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr Val Ala 
        195                 200                 205             


Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr Val Lys 
    210                 215                 220                 


Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu Ser Leu 
225                 230                 235                 240 


Asn Tyr Ser Val Tyr Thr Thr Asn Ser Asp Val Trp Ser Tyr Gly Val 
                245                 250                 255     


Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys Gly Met 
            260                 265                 270         


Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg Leu Glu 
        275                 280                 285             


Lys Pro Leu Asn Cys Asp Asp Glu Val Tyr Asp Leu Met Arg Gln Cys 
    290                 295                 300                 


Trp Arg Glu Lys Pro Tyr Glu Arg Pro Ser Phe Ala Gln Ile Leu Val 
305                 310                 315                 320 


Ser Leu Asn Arg Met Leu Glu Glu Arg Lys Thr Tyr Val Asn Thr Thr 
                325                 330                 335     


Leu Tyr Glu Lys Phe Thr Tyr Ala Gly Ile Asp Cys Ser Ala Glu Glu 
            340                 345                 350         


Ala Ala 
        


<210>  2
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu 
1               5                   10                  15      


Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu 
            20                  25                  30          


Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp 
        35                  40                  45              


Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly 
    50                  55                  60                  


His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly 
65                  70                  75                  80  


Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp 
                85                  90                  95      


Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile 
            100                 105                 110         


Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe 
        115                 120                 125             


Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe 
    130                 135                 140                 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr 
145                 150                 155                 160 


Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr 
                165                 170                 175     


Val Lys Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu 
            180                 185                 190         


Ser Leu Asn Tyr Ser Val Tyr Thr Thr Asn Ser Asp Val Trp Ser Tyr 
        195                 200                 205             


Gly Val Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys 
    210                 215                 220                 


Gly Met Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg 
225                 230                 235                 240 


Leu Glu Lys Pro Leu Asn Cys Asp Asp Glu Val Tyr Asp Leu Met Arg 
                245                 250                 255     


Gln Cys Trp Arg Glu Lys Pro Tyr Glu Arg Pro Ser Phe Ala Gln Ile 
            260                 265                 270         


Leu Val Ser Leu Asn Arg Met Leu Glu Glu Arg Lys Thr 
        275                 280                 285 


