                         SEQUENCE LISTING

<110>  Szkudlinski, Mariusz W.
       Weintraub, Bruce D.
 
<120>  Glycoprotein Hormone Long-Acting Superagonists

<130>  056815-5011-WO

<150>  US 61/900,094
<151>  2013-11-05

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified glycoprotein insert

<400>  1

Asn Val Thr Ile Asn Val 
1               5       


<210>  2
<211>  96
<212>  PRT
<213>  Bos taurus

<400>  2

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Pro Asp Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Val Arg Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  3
<211>  96
<212>  PRT
<213>  Ovis aries

<400>  3

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Pro Asp Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Val Arg Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  4
<211>  96
<212>  PRT
<213>  Equus caballus

<400>  4

Phe Pro Asp Gly Glu Phe Thr Thr Gln Asp Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Arg Glu Asn Lys Tyr Phe Phe Lys Leu Gly Val Pro Ile Tyr Gln Cys 
            20                  25                  30          


Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Arg 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile Lys Leu 
65                  70                  75                  80  


Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His Lys Ile 
                85                  90                  95      


<210>  5
<211>  96
<212>  PRT
<213>  Sus scrofa

<400>  5

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Leu Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Ala Arg Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  6
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro 
1               5                   10                  15      


Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys 
            20                  25                  30          


Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu 
        35                  40                  45              


Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser 
    50                  55                  60                  


Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn His Thr 
65                  70                  75                  80  


Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90          


<210>  7
<211>  102
<212>  PRT
<213>  Bos taurus

<400>  7

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val 
65                  70                  75                  80  


Met Gly Asn Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr 
                85                  90                  95      


Cys Tyr Tyr His Lys Ser 
            100         


<210>  8
<211>  102
<212>  PRT
<213>  Ovis aries

<400>  8

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Lys Pro Asp 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val 
65                  70                  75                  80  


Met Gly Asn Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr 
                85                  90                  95      


Cys Tyr Tyr His Lys Ser 
            100         


<210>  9
<211>  102
<212>  PRT
<213>  Equus caballus

<400>  9

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Thr Gln Asp 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly 
            20                  25                  30          


Val Pro Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val 
65                  70                  75                  80  


Met Gly Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr 
                85                  90                  95      


Cys Tyr His His Lys Ile 
            100         


<210>  10
<211>  102
<212>  PRT
<213>  Sus scrofa

<400>  10

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu Gly 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val 
65                  70                  75                  80  


Met Gly Asn Ala Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr 
                85                  90                  95      


Cys Tyr Tyr His Lys Ser 
            100         


<210>  11
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Pro Asp Val Asn Val Thr Ile Asn Val Thr Gln Asp Cys Pro Glu 
1               5                   10                  15      


Cys Thr Leu Arg Arg Asn Pro Phe Phe Ser Arg Pro Gly Ala Pro Ile 
            20                  25                  30          


Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu 
        35                  40                  45              


Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly 
65                  70                  75                  80  


Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr 
                85                  90                  95      


His Lys Ser 
            


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified glycoprotein insert

<400>  12

Thr Asn Val Thr Ile Asn Val 
1               5           


<210>  13
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro 
1               5                   10                  15      


Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys Met Gly Cys Cys 
            20                  25                  30          


Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu 
        35                  40                  45              


Val Gln Lys Asn Val Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ser 
    50                  55                  60                  


Tyr Asn Arg Val Thr Val Met Gly Gly Phe Lys Val Glu Asn His Thr 
65                  70                  75                  80  


Ala Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90          


<210>  14
<211>  102
<212>  PRT
<213>  Bos taurus

<400>  14

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Lys Leu Lys Arg Asn Lys Tyr Phe Ser Lys Pro Asp 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val 
65                  70                  75                  80  


Met Gly Asn Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr 
                85                  90                  95      


Cys Tyr Tyr His Lys Ser 
            100         


<210>  15
<211>  103
<212>  PRT
<213>  Bos taurus

<400>  15

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Ile Asn Val Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro 
            20                  25                  30          


Asp Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  16
<211>  103
<212>  PRT
<213>  Bos taurus

<400>  16

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Ile Asn Val Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Lys Leu Lys Arg Asn Lys Tyr Phe Ser Lys Pro 
            20                  25                  30          


Asp Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  17
<211>  98
<212>  PRT
<213>  Bos taurus

<400>  17

Phe Pro Asp Gly Glu Phe Asn Val Thr Met Gln Gly Cys Pro Glu Cys 
1               5                   10                  15      


Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile Tyr 
            20                  25                  30          


Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg 
        35                  40                  45              


Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr 
    50                  55                  60                  


Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Val 
65                  70                  75                  80  


Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His 
                85                  90                  95      


Lys Ser 
        


<210>  18
<211>  98
<212>  PRT
<213>  Bos taurus

<400>  18

Phe Pro Asp Gly Glu Phe Asn Val Thr Met Gln Gly Cys Pro Glu Cys 
1               5                   10                  15      


Lys Leu Lys Arg Asn Lys Tyr Phe Ser Lys Pro Asp Ala Pro Ile Tyr 
            20                  25                  30          


Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg 
        35                  40                  45              


Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr 
    50                  55                  60                  


Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Val 
65                  70                  75                  80  


Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His 
                85                  90                  95      


Lys Ser 
        


<210>  19
<211>  99
<212>  PRT
<213>  Bos taurus

<400>  19

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Met Gln Gly Cys Pro Glu 
1               5                   10                  15      


Cys Lys Leu Lys Arg Asn Lys Tyr Phe Ser Lys Pro Asp Ala Pro Ile 
            20                  25                  30          


Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala 
        35                  40                  45              


Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn 
65                  70                  75                  80  


Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr 
                85                  90                  95      


His Lys Ser 
            


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified glycoprotein insert

<400>  20

Val Asn Val Thr Ile Asn Val Thr 
1               5               


<210>  21
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Pro Asp Asn Val Thr Ile Asn Val Thr Gln Asp Cys Pro Glu Cys 
1               5                   10                  15      


Cys Thr Leu Arg Arg Asn Pro Phe Phe Ser Arg Pro Gly Ala Pro Ile 
            20                  25                  30          


Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu 
        35                  40                  45              


Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu Ser 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly Gly 
65                  70                  75                  80  


Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr Tyr 
                85                  90                  95      


His Lys Ser 
            


<210>  22
<211>  99
<212>  PRT
<213>  Bos taurus

<400>  22

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Met Gln Gly Cys Pro Glu 
1               5                   10                  15      


Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile 
            20                  25                  30          


Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala 
        35                  40                  45              


Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn 
65                  70                  75                  80  


Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr 
                85                  90                  95      


His Lys Ser 
            


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (5R)

<400>  23

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Arg Leu 
1               5                   10                  15      


Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (4R+1K)

<400>  24

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Arg Leu 
1               5                   10                  15      


Arg Lys Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


<210>  25
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (5R+Ins1)

<400>  25

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys 
        35              


<210>  26
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (5R+Ins2)

<400>  26

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Ile Asn Val Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro 
            20                  25                  30          


Asp Ala Pro Ile Tyr Gln Cys 
        35                  


<210>  27
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (5R+Ins3)

<400>  27

Phe Pro Asp Gly Glu Phe Asn Val Thr Met Gln Gly Cys Pro Glu Cys 
1               5                   10                  15      


Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile Tyr 
            20                  25                  30          


Gln Cys 
        


<210>  28
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (5R+Ins4)

<400>  28

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Met Gln Gly Cys Pro Glu 
1               5                   10                  15      


Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile 
            20                  25                  30          


Tyr Gln Cys 
        35  


<210>  29
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (4R+1K+Ins1)

<400>  29

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Lys Asn Arg Tyr Phe Ser Arg Pro Asp 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys 
        35              


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (4R+1K+Ins2)

<400>  30

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Ile Asn Val Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Lys Asn Arg Tyr Phe Ser Arg Pro 
            20                  25                  30          


Asp Ala Pro Ile Tyr Gln Cys 
        35                  


<210>  31
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (4R+1K+Ins3)

<400>  31

Phe Pro Asp Gly Glu Phe Asn Val Thr Met Gln Gly Cys Pro Glu Cys 
1               5                   10                  15      


Arg Leu Arg Lys Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile Tyr 
            20                  25                  30          


Gln Cys 
        


<210>  32
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bFSH superagonist (4R+1K+Ins4)

<400>  32

Phe Pro Asp Gly Glu Phe Thr Asn Val Thr Met Gln Gly Cys Pro Glu 
1               5                   10                  15      


Cys Arg Leu Arg Lys Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile 
            20                  25                  30          


Tyr Gln Cys 
        35  


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFSH superagonist (4R)

<400>  33

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Cys Thr Leu Arg Arg Asn 
1               5                   10                  15      


Arg Phe Phe Ser Arg Pro Gly Ala Pro Ile Leu Gln Cys 
            20                  25                  


<210>  34
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFSH superagonist (4R+Ins1)

<400>  34

Ala Pro Asp Val Asn Val Thr Ile Asn Val Thr Gln Asp Cys Pro Glu 
1               5                   10                  15      


Cys Cys Thr Leu Arg Arg Asn Arg Phe Phe Ser Arg Pro Gly Ala Pro 
            20                  25                  30          


Ile Leu Gln Cys 
        35      


<210>  35
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFSH superagonist (4R+Ins2)

<400>  35

Ala Pro Asp Asn Val Thr Ile Asn Val Thr Gln Asp Cys Pro Glu Cys 
1               5                   10                  15      


Cys Thr Leu Arg Arg Asn Arg Phe Phe Ser Arg Pro Gly Ala Pro Ile 
            20                  25                  30          


Leu Gln Cys 
        35  


<210>  36
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFSH superagonist (4R+Ins3)

<400>  36

Ala Pro Asp Asn Val Thr Gln Asp Cys Pro Glu Cys Cys Thr Leu Arg 
1               5                   10                  15      


Arg Asn Arg Phe Phe Ser Arg Pro Gly Ala Pro Ile Leu Gln Cys 
            20                  25                  30      


<210>  37
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFSH superagonist (4R+Ins4)

<400>  37

Ala Pro Asp Val Asn Val Thr Gln Asp Cys Pro Glu Cys Cys Thr Leu 
1               5                   10                  15      


Arg Arg Asn Arg Phe Phe Ser Arg Pro Gly Ala Pro Ile Leu Gln Cys 
            20                  25                  30          


<210>  38
<211>  101
<212>  PRT
<213>  Equus caballus

<400>  38

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Gln Asp Cys 
1               5                   10                  15      


Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val 
            20                  25                  30          


Pro Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr 
        35                  40                  45              


Pro Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser 
    50                  55                  60                  


Glu Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met 
65                  70                  75                  80  


Gly Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys 
                85                  90                  95      


Tyr His His Lys Ile 
            100     


<210>  39
<211>  101
<212>  PRT
<213>  Equus caballus

<400>  39

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Gln Asp Cys 
1               5                   10                  15      


Pro Glu Cys Arg Leu Arg Lys Asn Arg Tyr Phe Phe Arg Leu Gly Val 
            20                  25                  30          


Pro Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr 
        35                  40                  45              


Pro Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser 
    50                  55                  60                  


Glu Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met 
65                  70                  75                  80  


Gly Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys 
                85                  90                  95      


Tyr His His Lys Ile 
            100     


<210>  40
<211>  102
<212>  PRT
<213>  Equus caballus

<400>  40

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Thr Gln Asp 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Lys Asn Arg Tyr Phe Phe Arg Leu Gly 
            20                  25                  30          


Val Pro Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val 
65                  70                  75                  80  


Met Gly Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr 
                85                  90                  95      


Cys Tyr His His Lys Ile 
            100         


<210>  41
<211>  101
<212>  PRT
<213>  Equus caballus

<400>  41

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Gln Asp Cys 
1               5                   10                  15      


Pro Glu Cys Arg Leu Arg His Asn Arg Tyr Phe Phe Arg Leu Gly Val 
            20                  25                  30          


Pro Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr 
        35                  40                  45              


Pro Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser 
    50                  55                  60                  


Glu Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met 
65                  70                  75                  80  


Gly Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys 
                85                  90                  95      


Tyr His His Lys Ile 
            100     


<210>  42
<211>  102
<212>  PRT
<213>  Equus caballus

<400>  42

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Thr Gln Asp 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg His Asn Arg Tyr Phe Phe Arg Leu Gly 
            20                  25                  30          


Val Pro Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val 
65                  70                  75                  80  


Met Gly Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr 
                85                  90                  95      


Cys Tyr His His Lys Ile 
            100         


<210>  43
<211>  28
<212>  PRT
<213>  Equus caballus

<400>  43

Ala Pro Asp Val Gln Asp Cys Pro Glu Cys Thr Leu Gln Glu Asn Pro 
1               5                   10                  15      


Phe Phe Ser Gln Pro Gly Ala Pro Ile Leu Gln Cys 
            20                  25              


<210>  44
<211>  32
<212>  PRT
<213>  Equus caballus

<400>  44

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Pro Asp Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


<210>  45
<211>  103
<212>  PRT
<213>  Sus scrofa

<400>  45

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu 
            20                  25                  30          


Gly Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Ala Arg Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  46
<211>  103
<212>  PRT
<213>  Ovis aries

<400>  46

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro 
            20                  25                  30          


Asp Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  47
<211>  96
<212>  PRT
<213>  Canis lupus

<400>  47

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Leu Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Ala Lys Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  48
<211>  102
<212>  PRT
<213>  Canis lupus

<400>  48

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu Gly 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val 
65                  70                  75                  80  


Met Gly Asn Ala Lys Val Glu Asn His Thr Glu Cys His Cys Ser Thr 
                85                  90                  95      


Cys Tyr Tyr His Lys Ser 
            100         


<210>  49
<211>  103
<212>  PRT
<213>  Canis lupus

<400>  49

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu 
            20                  25                  30          


Gly Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Ala Lys Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  50
<211>  96
<212>  PRT
<213>  Felis catus

<400>  50

Phe Pro Asp Gly Glu Phe Thr Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Leu Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Ala Lys Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr His His Lys Ile 
                85                  90                  95      


<210>  51
<211>  102
<212>  PRT
<213>  Felis catus

<400>  51

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Gln Gly 
1               5                   10                  15      


Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu Gly 
            20                  25                  30          


Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro 
        35                  40                  45              


Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr 
    50                  55                  60                  


Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val 
65                  70                  75                  80  


Met Gly Asn Ala Lys Val Glu Asn His Thr Glu Cys His Cys Ser Thr 
                85                  90                  95      


Cys Tyr His His Lys Ile 
            100         


<210>  52
<211>  103
<212>  PRT
<213>  Felis catus

<400>  52

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Thr Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu 
            20                  25                  30          


Gly Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Ala Lys Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr His His Lys Ile 
            100             


<210>  53
<211>  96
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  53

Phe Pro Asp Gly Glu Phe Ala Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Leu Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Ala Lys Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  54
<211>  103
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  54

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Ala Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu 
            20                  25                  30          


Gly Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Ala Lys Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  55
<211>  96
<212>  PRT
<213>  Capra aegagrus

<400>  55

Phe Pro Asp Gly Glu Phe Met Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Lys Asn Lys Tyr Phe Ser Lys Pro Asp Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Thr Gly Asn Val Arg Val 
65                  70                  75                  80  


Glu Asn His Thr Asp Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  56
<211>  103
<212>  PRT
<213>  Capra aegagrus

<400>  56

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Met Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro 
            20                  25                  30          


Asp Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Thr Gly Asn Val Arg Val Glu Asn His Thr Asp Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  57
<211>  96
<212>  PRT
<213>  Didelphis virginiana

<400>  57

Phe Pro Asp Gly Glu Phe Ile Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Tyr Phe Ser Lys Leu Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn Ala Lys Val 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  58
<211>  103
<212>  PRT
<213>  Didelphis virginiana

<400>  58

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Ile Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu 
            20                  25                  30          


Gly Ala Pro Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr 
65                  70                  75                  80  


Val Met Gly Asn Ala Lys Val Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  59
<211>  96
<212>  PRT
<213>  Gallus gallus

<400>  59

Phe Pro Asp Gly Glu Phe Leu Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Gly Glu Asn Arg Phe Phe Ser Lys Pro Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Thr Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Met Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ile Thr Leu Lys Asp Asn Val Lys Ile 
65                  70                  75                  80  


Glu Asn His Thr Asp Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  60
<211>  103
<212>  PRT
<213>  Gallus gallus

<400>  60

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Leu Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Phe Phe Ser Arg Pro 
            20                  25                  30          


Gly Ala Pro Ile Tyr Gln Cys Thr Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Met Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ile Thr 
65                  70                  75                  80  


Leu Lys Asp Asn Val Lys Ile Glu Asn His Thr Asp Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  61
<211>  96
<212>  PRT
<213>  Meleagris gallopavo

<400>  61

Phe Pro Asp Gly Glu Phe Leu Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Gly Glu Asn Arg Phe Phe Ser Lys Pro Gly Ala Pro Ile Tyr Gln Cys 
            20                  25                  30          


Thr Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Met Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ile Thr Leu Lys Asp Asn Val Lys Ile 
65                  70                  75                  80  


Glu Asn His Thr Asp Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  62
<211>  103
<212>  PRT
<213>  Meleagris gallopavo

<400>  62

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Leu Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Phe Phe Ser Arg Pro 
            20                  25                  30          


Gly Ala Pro Ile Tyr Gln Cys Thr Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Met Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ile Thr 
65                  70                  75                  80  


Leu Lys Asp Asn Val Lys Ile Glu Asn His Thr Asp Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  63
<211>  96
<212>  PRT
<213>  Struthio camelus

<400>  63

Phe Pro Asp Gly Glu Phe Leu Met Gln Gly Cys Pro Glu Cys Lys Leu 
1               5                   10                  15      


Gly Glu Asn Arg Phe Phe Ser Lys Pro Gly Ala Pro Val Tyr Gln Cys 
            20                  25                  30          


Thr Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Thr Lys Ile Thr Leu Lys Asp Asn Val Lys Ile 
65                  70                  75                  80  


Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95      


<210>  64
<211>  103
<212>  PRT
<213>  Struthio camelus

<400>  64

Phe Pro Asp Gly Glu Phe Asn Val Thr Ile Asn Val Thr Leu Met Gln 
1               5                   10                  15      


Gly Cys Pro Glu Cys Arg Leu Arg Arg Asn Arg Phe Phe Ser Arg Pro 
            20                  25                  30          


Gly Ala Pro Val Tyr Gln Cys Thr Gly Cys Cys Phe Ser Arg Ala Tyr 
        35                  40                  45              


Pro Thr Pro Leu Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile 
    50                  55                  60                  


Thr Ser Glu Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ile Thr 
65                  70                  75                  80  


Leu Lys Asp Asn Val Lys Ile Glu Asn His Thr Glu Cys His Cys Ser 
                85                  90                  95      


Thr Cys Tyr Tyr His Lys Ser 
            100             


<210>  65
<211>  92
<212>  PRT
<213>  Ictalurus punctatus

<400>  65

Phe Pro Asn Asn Asp Phe Gly Cys Glu Glu Cys Lys Leu Lys Glu Asn 
1               5                   10                  15      


Asn Ile Phe Ser Lys Pro Gly Ala Pro Val Tyr Gln Cys Met Gly Cys 
            20                  25                  30          


Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Glu Lys Thr Met 
        35                  40                  45              


Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys Val Ala Lys 
    50                  55                  60                  


Glu Val Lys Arg Val Ile Val Asn Asp Val Lys Leu Met Asn His Thr 
65                  70                  75                  80  


Asp Cys His Cys Ser Thr Cys Tyr Tyr His Lys Phe 
                85                  90          


<210>  66
<211>  97
<212>  PRT
<213>  Ictalurus punctatus

<400>  66

Phe Pro Asn Val Thr Ile Asn Val Thr Asp Phe Gly Cys Glu Glu Cys 
1               5                   10                  15      


Arg Leu Arg Arg Asn Arg Ile Phe Ser Arg Pro Gly Ala Pro Val Tyr 
            20                  25                  30          


Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg 
        35                  40                  45              


Ser Glu Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr 
    50                  55                  60                  


Cys Cys Val Ala Lys Glu Val Lys Arg Val Ile Val Asn Asp Val Lys 
65                  70                  75                  80  


Leu Met Asn His Thr Asp Cys His Cys Ser Thr Cys Tyr Tyr His Lys 
                85                  90                  95      


Phe 
    


<210>  67
<211>  95
<212>  PRT
<213>  Cyprinus carpio

<400>  67

Tyr Pro Arg Asn Asp Met Asn Asn Phe Gly Cys Glu Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Asn Ile Phe Ser Lys Pro Gly Ala Pro Val Tyr Gln Cys 
            20                  25                  30          


Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu Arg Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Glu Val Lys Arg Val Leu Val Asn Asp Val Lys Leu Val 
65                  70                  75                  80  


Asn His Thr Asp Cys His Cys Ser Thr Cys Tyr Tyr His Lys Ser 
                85                  90                  95  


<210>  68
<211>  100
<212>  PRT
<213>  Cyprinus carpio

<400>  68

Tyr Pro Arg Asn Asp Met Asn Val Thr Ile Asn Val Thr Phe Gly Cys 
1               5                   10                  15      


Glu Glu Cys Arg Leu Arg Arg Asn Arg Ile Phe Ser Arg Pro Gly Ala 
            20                  25                  30          


Pro Val Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr 
        35                  40                  45              


Pro Leu Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser 
    50                  55                  60                  


Glu Ala Thr Cys Cys Val Ala Lys Glu Val Lys Arg Val Leu Val Asn 
65                  70                  75                  80  


Asp Val Lys Leu Val Asn His Thr Asp Cys His Cys Ser Thr Cys Tyr 
                85                  90                  95      


Tyr His Lys Ser 
            100 


<210>  69
<211>  95
<212>  PRT
<213>  Salmo salar

<400>  69

Tyr Pro Asn Ser Asp Met Thr Asn Val Gly Cys Glu Glu Cys Lys Leu 
1               5                   10                  15      


Lys Glu Asn Lys Val Phe Ser Asn Pro Gly Ala Pro Val Tyr Gln Cys 
            20                  25                  30          


Thr Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Leu His Ser Lys 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Glu Gly Lys Arg Val Val Val Asp Asn Ile Lys Leu Thr 
65                  70                  75                  80  


Asn His Thr Glu Cys Trp Cys Asn Thr Cys Tyr His His Lys Ser 
                85                  90                  95  


<210>  70
<211>  100
<212>  PRT
<213>  Salmo salar

<400>  70

Tyr Pro Asn Ser Asp Met Thr Asn Val Thr Ile Asn Val Thr Gly Cys 
1               5                   10                  15      


Glu Glu Cys Arg Leu Arg Arg Asn Arg Val Phe Ser Arg Pro Gly Ala 
            20                  25                  30          


Pro Val Tyr Gln Cys Thr Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr 
        35                  40                  45              


Pro Leu His Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser 
    50                  55                  60                  


Glu Ala Thr Cys Cys Val Ala Lys Glu Gly Lys Arg Val Val Val Asp 
65                  70                  75                  80  


Asn Ile Lys Leu Thr Asn His Thr Glu Cys Trp Cys Asn Thr Cys Tyr 
                85                  90                  95      


His His Lys Ser 
            100 


<210>  71
<211>  99
<212>  PRT
<213>  Salmo salar

<400>  71

Tyr Pro Asn Ser Asp Met Asn Val Thr Ile Asn Val Thr Gly Cys Glu 
1               5                   10                  15      


Glu Cys Arg Leu Arg Arg Asn Arg Val Phe Ser Arg Pro Gly Ala Pro 
            20                  25                  30          


Val Tyr Gln Cys Thr Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
        35                  40                  45              


Leu His Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu 
    50                  55                  60                  


Ala Thr Cys Cys Val Ala Lys Glu Gly Lys Arg Val Val Val Asp Asn 
65                  70                  75                  80  


Ile Lys Leu Thr Asn His Thr Glu Cys Trp Cys Asn Thr Cys Tyr His 
                85                  90                  95      


His Lys Ser 
            


<210>  72
<211>  98
<212>  PRT
<213>  Equus caballus

<400>  72

Phe Pro Asp Gly Glu Phe Asn Asn Thr Thr Gln Asp Cys Pro Glu Cys 
1               5                   10                  15      


Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro Ile Tyr 
            20                  25                  30          


Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg 
        35                  40                  45              


Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr 
    50                  55                  60                  


Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile 
65                  70                  75                  80  


Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His 
                85                  90                  95      


Lys Ile 
        


<210>  73
<211>  99
<212>  PRT
<213>  Equus caballus

<400>  73

Phe Pro Asp Gly Glu Phe Asn Asn Thr Thr Thr Gln Asp Cys Pro Glu 
1               5                   10                  15      


Cys Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro Ile 
            20                  25                  30          


Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala 
        35                  40                  45              


Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn 
65                  70                  75                  80  


Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His 
                85                  90                  95      


His Lys Ile 
            


<210>  74
<211>  99
<212>  PRT
<213>  Equus caballus

<400>  74

Phe Pro Asp Gly Glu Phe Asn Asn Ser Thr Thr Gln Asp Cys Pro Glu 
1               5                   10                  15      


Cys Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro Ile 
            20                  25                  30          


Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala 
        35                  40                  45              


Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn 
65                  70                  75                  80  


Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His 
                85                  90                  95      


His Lys Ile 
            


<210>  75
<211>  100
<212>  PRT
<213>  Equus caballus

<400>  75

Phe Pro Asp Gly Glu Phe Asn Asn Ser Ser Thr Thr Gln Asp Cys Pro 
1               5                   10                  15      


Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro 
            20                  25                  30          


Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
        35                  40                  45              


Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu 
    50                  55                  60                  


Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly 
65                  70                  75                  80  


Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr 
                85                  90                  95      


His His Lys Ile 
            100 


<210>  76
<211>  100
<212>  PRT
<213>  Equus caballus

<400>  76

Phe Pro Asp Gly Glu Phe Asn Asn Thr Ser Thr Thr Gln Asp Cys Pro 
1               5                   10                  15      


Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro 
            20                  25                  30          


Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
        35                  40                  45              


Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu 
    50                  55                  60                  


Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly 
65                  70                  75                  80  


Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr 
                85                  90                  95      


His His Lys Ile 
            100 


<210>  77
<211>  99
<212>  PRT
<213>  Sus scrofa

<400>  77

Phe Pro Asp Gly Glu Phe Asn Asn Thr Thr Met Gln Gly Cys Pro Glu 
1               5                   10                  15      


Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu Gly Ala Pro Ile 
            20                  25                  30          


Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala 
        35                  40                  45              


Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn 
65                  70                  75                  80  


Ala Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr 
                85                  90                  95      


His Lys Ser 
            


<210>  78
<211>  100
<212>  PRT
<213>  Sus scrofa

<400>  78

Phe Pro Asp Gly Glu Phe Asn Asn Thr Thr Thr Met Gln Gly Cys Pro 
1               5                   10                  15      


Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Leu Gly Ala Pro 
            20                  25                  30          


Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
        35                  40                  45              


Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu 
    50                  55                  60                  


Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly 
65                  70                  75                  80  


Asn Ala Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr 
                85                  90                  95      


Tyr His Lys Ser 
            100 


<210>  79
<211>  99
<212>  PRT
<213>  Ovis aries

<400>  79

Phe Pro Asp Gly Glu Phe Asn Asn Thr Thr Met Gln Gly Cys Pro Glu 
1               5                   10                  15      


Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro Ile 
            20                  25                  30          


Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala 
        35                  40                  45              


Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ala 
    50                  55                  60                  


Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly Asn 
65                  70                  75                  80  


Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr Tyr 
                85                  90                  95      


His Lys Ser 
            


<210>  80
<211>  100
<212>  PRT
<213>  Ovis aries

<400>  80

Phe Pro Asp Gly Glu Phe Asn Asn Thr Thr Thr Met Gln Gly Cys Pro 
1               5                   10                  15      


Glu Cys Arg Leu Arg Arg Asn Arg Tyr Phe Ser Arg Pro Asp Ala Pro 
            20                  25                  30          


Ile Tyr Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
        35                  40                  45              


Ala Arg Ser Lys Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu 
    50                  55                  60                  


Ala Thr Cys Cys Val Ala Lys Ala Phe Thr Lys Ala Thr Val Met Gly 
65                  70                  75                  80  


Asn Val Arg Val Glu Asn His Thr Glu Cys His Cys Ser Thr Cys Tyr 
                85                  90                  95      


Tyr His Lys Ser 
            100 


<210>  81
<211>  96
<212>  PRT
<213>  Equus caballus

<400>  81

Phe Pro Asp Gly Glu Phe Thr Thr Gln Asp Cys Pro Glu Cys Arg Leu 
1               5                   10                  15      


Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro Ile Tyr Gln Cys 
            20                  25                  30          


Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Arg 
        35                  40                  45              


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr Cys Cys 
    50                  55                  60                  


Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile Lys Leu 
65                  70                  75                  80  


Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His Lys Ile 
                85                  90                  95      


<210>  82
<211>  97
<212>  PRT
<213>  Equus caballus

<400>  82

Phe Pro Asp Gly Glu Phe Asn Thr Thr Gln Asp Cys Pro Glu Cys Arg 
1               5                   10                  15      


Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro Ile Tyr Gln 
            20                  25                  30          


Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser 
        35                  40                  45              


Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr Cys 
    50                  55                  60                  


Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile Lys 
65                  70                  75                  80  


Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His Lys 
                85                  90                  95      


Ile 
    


<210>  83
<211>  98
<212>  PRT
<213>  Equus caballus

<400>  83

Phe Pro Asp Gly Glu Phe Asn Val Thr Thr Gln Asp Cys Pro Glu Cys 
1               5                   10                  15      


Arg Leu Arg Arg Asn Arg Tyr Phe Phe Arg Leu Gly Val Pro Ile Tyr 
            20                  25                  30          


Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg 
        35                  40                  45              


Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr 
    50                  55                  60                  


Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile 
65                  70                  75                  80  


Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His 
                85                  90                  95      


Lys Ile 
        


