                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Boakye, Ken
       Del Vecchio, Alfred
       Kehoe, John
       Lacy, Eilyn
       Murray, Lynne
       Ryan, Mary
       Santulli-Marotto, Sandra
       Teplyakov, Alexey
       Wheeler, John
       Whitaker, Brian
 
<120>  Anti-CCL17 antibodies

<130>  JBI5040WOPCT

<140>  To be assigned
<141>  2014-11-06

<150>  61/900,596
<151>  2013-11-06

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Arg Gly Thr Asn Val Gly Arg Glu Cys Cys Leu Glu Tyr Phe Lys 
1               5                   10                  15      


Gly Ala Ile Pro Leu Arg Lys Leu Lys Thr Trp Tyr Gln Thr Ser Glu 
            20                  25                  30          


Asp Cys Ser Arg Asp Ala Ile Val Phe Val Thr Val Gln Gly Arg Ala 
        35                  40                  45              


Ile Cys Ser Asp Pro Asn Asn Lys Arg Val Lys Asn Ala Val Lys Tyr 
    50                  55                  60                  


Leu Gln Ser Leu Glu Arg Ser 
65                  70      


<210>  2
<211>  72
<212>  PRT
<213>  Macaca fascicularis

<400>  2

Met Ala Arg Gly Thr Asn Val Gly Arg Glu Cys Cys Leu Lys Tyr Phe 
1               5                   10                  15      


Lys Gly Ala Ile Pro Leu Arg Lys Leu Lys Thr Trp Tyr Gln Thr Ser 
            20                  25                  30          


Glu Asp Cys Ser Arg Asp Ala Ile Val Phe Val Thr Val Gln Asn Lys 
        35                  40                  45              


Ala Ile Cys Ser Asp Pro Asn Asp Lys Lys Val Lys Lys Ala Leu Lys 
    50                  55                  60                  


Tyr Leu Gln Ser Leu Glu Arg Ser 
65                  70          


<210>  3
<211>  69
<212>  PRT
<213>  Macaca fascicularis

<400>  3

Gly Pro Tyr Gly Ala Asn Met Glu Asp Ser Val Cys Cys Arg Asp Tyr 
1               5                   10                  15      


Val Arg Tyr Arg Met Pro Leu Arg Val Val Lys His Phe Tyr Trp Thr 
            20                  25                  30          


Ser Asp Ser Cys Pro Arg Pro Gly Val Val Leu Leu Thr Ser Arg Asp 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Arg Val Pro Trp Val Lys Met Ile Leu 
    50                  55                  60                  


Asn Lys Leu Ser Gln 
65                  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR1 of C17F24

<400>  4

Ser Tyr Trp Ile Gly 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR2 of C17F24

<400>  5

Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR3 of C17F24

<400>  6

Val Gly Pro Ala Asp Val Trp Asp Ser Phe Asp Tyr 
1               5                   10          


<210>  7
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17F24

<400>  7

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B234

<400>  8

Lys Ser Ser Gln Ser Val Leu Leu Ser Phe Asp Asn Ile Asn Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 fo C17B235

<400>  9

Lys Ser Ser Gln Ser Val Leu Tyr Ser Phe Tyr Asn Phe Asn Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B236

<400>  10

Lys Ser Ser Gln Ser Val Leu Leu Ser Pro Trp Asn Ser Asn Gln Leu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B237

<400>  11

Lys Ser Ser Gln Ser Val Leu Thr Ser Tyr Asn Asn Ser Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B238

<400>  12

Lys Ser Ser Gln Ser Val Leu Ile Ser Ala Phe Asn Gln Asn Pro Leu 
1               5                   10                  15      


Ala 
    


<210>  13
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B239

<400>  13

Lys Ser Ser Gln Ser Val Leu Ser Ser Phe Thr Asn Thr Asn Thr Leu 
1               5                   10                  15      


Ala 
    


<210>  14
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B240

<400>  14

Lys Ser Ser Gln Ser Val Leu Tyr Ser His Val Asn Tyr Asn Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B241

<400>  15

Lys Ser Ser Gln Ser Val Leu Asn Ser Phe Thr Asn Asn Asn Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B242

<400>  16

Lys Ser Ser Gln Ser Val Leu Phe Ser His Asp Asn Leu Asn Thr Leu 
1               5                   10                  15      


Ala 
    


<210>  17
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B243

<400>  17

Lys Ser Ser Gln Ser Val Leu Asn Ser Phe Asp Asn Lys Asn Asp Leu 
1               5                   10                  15      


Ala 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 of C17B244

<400>  18

Lys Ser Ser Gln Ser Val Leu Ser Ser Ile Thr Asn Val Asn Asp Leu 
1               5                   10                  15      


Ala 
    


<210>  19
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 fo C17F24

<400>  19

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B234

<400>  20

Asn Ala Ser Thr Arg Glu Ser 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 fo C17B235

<400>  21

His Ala Ser Thr Arg Glu Ser 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B236

<400>  22

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B237

<400>  23

Leu Ala Ser Thr Arg Glu Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B238

<400>  24

Asp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B241

<400>  25

Glu Ala Ser Thr Arg Glu Ser 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B244

<400>  26

Thr Ala Ser Thr Arg Glu Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17F24

<400>  27

Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B234

<400>  28

Gln Gln Phe Tyr Ser Val Pro Ser Thr 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B235

<400>  29

Gln Gln Phe Tyr Ala Thr Pro Phe Thr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B236

<400>  30

Gln Gln Tyr Tyr Leu Ile Pro Ser Thr 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B237

<400>  31

Gln Gln Tyr Leu Ser Pro Pro Ser Thr 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B238

<400>  32

Gln Gln Tyr Gln Phe Ile Pro Phe Thr 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B239

<400>  33

Gln Gln Tyr Leu Ile Tyr Pro Ser Thr 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 fo C17B240

<400>  34

Gln Gln Tyr Tyr Thr Leu Pro Ala Thr 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B241

<400>  35

Gln Gln Thr Asn Ser Ile Pro Leu Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B242

<400>  36

Gln Gln Tyr Tyr Ala Val Pro Gln Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B243

<400>  37

Gln Gln His Trp Gln Thr Pro Leu Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 of C17B244

<400>  38

Gln Gln Tyr Tyr His Asp Pro Phe Thr 
1               5                   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B257

<400>  39

Ala Ala Ser Thr Arg Glu Ser 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 of C17B262

<400>  40

Ser Ala Ser Thr Arg Glu Ser 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 fo C17B264

<400>  41

Ile Ala Ser Thr Arg Glu Ser 
1               5           


<210>  42
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR3 of C17B293

<400>  42

Val Gly Pro Ala Asp Val Trp Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR3 of C17B294

<400>  43

Val Gly Pro Ala Asp Val Trp Asp Thr Phe Asp Tyr 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR3 of C17B295

<400>  44

Val Gly Pro Ala Asp Val Trp Glu Ser Phe Asp Tyr 
1               5                   10          


<210>  45
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH of C17F24, C17B234, C17B235, C17B236, 
       C17B237, C17B238, C17B239, C17B240, C17B241, 
       C17B242, C17B243, C17B244, C17B257, C17B258, 
       C17B260, C17B262, C17B266, C17B264

<400>  45

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Ala Asp Val Trp Asp Ser Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  46
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH of C17M293

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Ala Asp Val Trp Asp Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH of C17B294

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Ala Asp Val Trp Asp Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH of C17B295

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Ala Asp Val Trp Glu Ser Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  49
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17F24

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  50
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B234

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asn Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  51
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B235

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Phe Tyr Asn Phe Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr His Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ala Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  52
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B236

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Pro Trp Asn Ser Asn Gln Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Leu Ile Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  53
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B237

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Thr Ser 
            20                  25                  30          


Tyr Asn Asn Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Leu Ser Pro Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  54
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B238

<400>  54

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ile Ser 
            20                  25                  30          


Ala Phe Asn Gln Asn Pro Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Gln Phe Ile Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  55
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B239

<400>  55

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser 
            20                  25                  30          


Phe Thr Asn Thr Asn Thr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr His Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Leu Ile Tyr Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  56
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B240

<400>  56

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


His Val Asn Tyr Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asn Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Leu Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  57
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B241

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asn Ser 
            20                  25                  30          


Phe Thr Asn Asn Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Glu Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Thr Asn Ser Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  58
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B242

<400>  58

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


His Asp Asn Leu Asn Thr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr His Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ala Val Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  59
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B243

<400>  59

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asn Ser 
            20                  25                  30          


Phe Asp Asn Lys Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Glu Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Trp Gln Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  60
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B244

<400>  60

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser 
            20                  25                  30          


Ile Thr Asn Val Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Thr Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr His Asp Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  61
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B257

<400>  61

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  62
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B258

<400>  62

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  63
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B260

<400>  63

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  64
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B262

<400>  64

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  65
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B263

<400>  65

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Thr Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  66
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL of C17B264

<400>  66

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ile Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  67
<211>  447
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CB302 HC

<400>  67

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Ala Asp Val Trp Asp Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Thr Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  68
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CB302 LC

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  69
<211>  447
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CB301 HC

<400>  69

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Ala Asp Val Trp Asp Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Thr Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  70
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CB301 LC

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Leu Ser 
            20                  25                  30          


Phe Asp Asn Ile Asn Lys Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Val Pro Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  71
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be Ser, Ala or Thr

<400>  71

Val Gly Pro Ala Asp Val Trp Asp Xaa Phe Asp Tyr 
1               5                   10          


<210>  72
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Leu, Tyr, Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be Phe, Pro, His or Ile

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be Asp, Tyr, Trp, Thr or Val

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa may be Ile, Phe, Ser, Thr, Tyr, Asn, Lys or Val

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be Lys, Ala, Qln, Thr or Asp

<400>  72

Lys Ser Ser Gln Ser Val Leu Xaa Ser Xaa Xaa Asn Xaa Asn Xaa Leu 
1               5                   10                  15      


Ala 
    


<210>  73
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Asn, His, Gly, Glu, Thr or Asp

<400>  73

Xaa Ala Ser Thr Arg Glu 
1               5       


<210>  74
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LCDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Phe, Tyr, Thr or His

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Tyr, Leu, Asn or Trp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be Ser, Ala, Leu, Ile, Thr, Qln or His

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Val, Thr, Ile, Tyr, Leu or Asp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Ser, Phe, Ala or Leu

<400>  74

Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  75
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa may be Ser, Ala or Thr

<400>  75

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Ala Asp Val Trp Asp Xaa Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa may be Leu, Tyr, Ser or Asn

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa may be Phe,Pro, His or Ile

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa may be Asp, Tyr, Trp, Thr or Val

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa may be Ile, Phe, Ser, Thr, Tyr, Asn, Lys or Val

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa may be Lys, Ala, Qln, Thr or Asp

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa may be Asn, His, Gly, Glu, Thr or Asp

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa may be Phe, Tyr, Thr or His

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa may be Tyr, Leu, Asn or Trp

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa may be Ser, Ala, Leu, Ile, Thr, Qln or His

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa may be Val, Thr, Ile, Tyr, Leu or Asp

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa may be Ser, Phe, Ala or Leu

<400>  76

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Xaa Ser 
            20                  25                  30          


Xaa Xaa Asn Xaa Asn Xaa Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Xaa Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Xaa Xaa Xaa Xaa Pro Xaa Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


