                               SEQUENCE LISTING

<110> SHRINERS HOSPITALS FOR CHILDREN
 
<120> METHOD FOR TREATING OSTEOGENESIS IMPERFECTA TYPE V

<130> 006910.5987

<140> PCT/US2014/064323
<141> 2014-11-06

<150> 61/900,872
<151> 2013-11-06

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 751
<212> DNA
<213> Homo sapiens

<400> 1
accagtctga gtgtggaaga gacggcgctg gaacccatgg acacggcgta tccccgcgag       60

gacacccggg cccccacgcc cagcaaggcc ggtgcccaca cagccctcac actgggggcc      120

ccgcaccccc cgcctcgaga ccacttgatc tggtcggtgt tcagcaccct ctacctgaat      180

ctgtgttgcc tcggcttcct ggcgctggcc tactccatca aggcccgaga tcagaaggtg      240

gttggtgacc tggaagcggc ccggcgtttt ggctccaaag ccaagtgcta caacatcctg      300

gccgcgatgt ggacgctggt gccgccactg ctgctcctgg ggctggtggt gactggtgcc      360

ctgcacctgg cccggctggc caaggactct gccgccttct tcagcaccaa gtttgatgac      420

gcggactatg actgacaggc tgggtcctga tctggggcac tagccccagg acactgaccc      480

caggctgctg cccctggggc ccaatactga ctccccggag cctggccctc cttctgtggg      540

gcctccatcc ctgccccatc ctgatcctgg ggccctccag ccccaacatg ggcacctaag      600

gctgaaccag tcagaccccg gggtcttcac cctaacccga gagttcccgg gccctaactc      660

tgcccccgat cctgcccctc cctcctcaca ctccaggccc ctcggttcca cgattaaaag      720

tgcctggttc cagaaaaaaa aaaaaaaaaa a                                     751


<210> 2
<211> 132
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Thr Ala Tyr Pro Arg Glu Asp Thr Arg Ala Pro Thr Pro Ser 
1               5                   10                  15      


Lys Ala Gly Ala His Thr Ala Leu Thr Leu Gly Ala Pro His Pro Pro 
            20                  25                  30          


Pro Arg Asp His Leu Ile Trp Ser Val Phe Ser Thr Leu Tyr Leu Asn 
        35                  40                  45              


Leu Cys Cys Leu Gly Phe Leu Ala Leu Ala Tyr Ser Ile Lys Ala Arg 
    50                  55                  60                  


Asp Gln Lys Val Val Gly Asp Leu Glu Ala Ala Arg Arg Phe Gly Ser 
65                  70                  75                  80  


Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu Val Pro 
                85                  90                  95      


Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His Leu Ala 
            100                 105                 110         


Arg Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe Asp Asp 
        115                 120                 125             


Ala Asp Tyr Asp 
    130         


<210> 3
<211> 751
<212> DNA
<213> Homo sapiens

<400> 3
accagtctga gtgtggaaga gatggcgctg gaacccatgg acacggcgta tccccgcgag       60

gacacccggg cccccacgcc cagcaaggcc ggtgcccaca cagccctcac actgggggcc      120

ccgcaccccc cgcctcgaga ccacttgatc tggtcggtgt tcagcaccct ctacctgaat      180

ctgtgttgcc tcggcttcct ggcgctggcc tactccatca aggcccgaga tcagaaggtg      240

gttggtgacc tggaagcggc ccggcgtttt ggctccaaag ccaagtgcta caacatcctg      300

gccgcgatgt ggacgctggt gccgccactg ctgctcctgg ggctggtggt gactggtgcc      360

ctgcacctgg cccggctggc caaggactct gccgccttct tcagcaccaa gtttgatgac      420

gcggactatg actgacaggc tgggtcctga tctggggcac tagccccagg acactgaccc      480

caggctgctg cccctggggc ccaatactga ctccccggag cctggccctc cttctgtggg      540

gcctccatcc ctgccccatc ctgatcctgg ggccctccag ccccaacatg ggcacctaag      600

gctgaaccag tcagaccccg gggtcttcac cctaacccga gagttcccgg gccctaactc      660

tgcccccgat cctgcccctc cctcctcaca ctccaggccc ctcggttcca cgattaaaag      720

tgcctggttc cagaaaaaaa aaaaaaaaaa a                                     751


<210> 4
<211> 137
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Leu Glu Pro Met Asp Thr Ala Tyr Pro Arg Glu Asp Thr Arg 
1               5                   10                  15      


Ala Pro Thr Pro Ser Lys Ala Gly Ala His Thr Ala Leu Thr Leu Gly 
            20                  25                  30          


Ala Pro His Pro Pro Pro Arg Asp His Leu Ile Trp Ser Val Phe Ser 
        35                  40                  45              


Thr Leu Tyr Leu Asn Leu Cys Cys Leu Gly Phe Leu Ala Leu Ala Tyr 
    50                  55                  60                  


Ser Ile Lys Ala Arg Asp Gln Lys Val Val Gly Asp Leu Glu Ala Ala 
65                  70                  75                  80  


Arg Arg Phe Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met 
                85                  90                  95      


Trp Thr Leu Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly 
            100                 105                 110         


Ala Leu His Leu Ala Arg Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser 
        115                 120                 125             


Thr Lys Phe Asp Asp Ala Asp Tyr Asp 
    130                 135         


<210> 5
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5
Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser 
1               5                   10                  


<210> 6
<211> 16
<212> PRT
<213> Homo sapiens

<400> 6
Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe Asp 
1               5                   10                  15      


<210> 7
<211> 5
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Leu Glu Pro 
1               5   


<210> 8
<211> 8
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Leu Glu Pro Met Asp Thr 
1               5               


<210> 9
<211> 4
<212> PRT
<213> Homo sapiens

<400> 9
Glu Asp Tyr Asn 
1               


<210> 10
<211> 4
<212> PRT
<213> Homo sapiens

<400> 10
Lys Asp Glu Leu 
1               


<210> 11
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser Cys 
1               5                   10                  15  


<210> 12
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Cys Gly Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys 
1               5                   10                  15      


Phe Asp 
        


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Met Ala Leu Glu Pro Met Asp Thr Gly Gly Cys 
1               5                   10      


<210> 14
<211> 144
<212> PRT
<213> Mus sp.

<400> 14
Met Ser His Asn Ser Gln Ala Phe Leu Ser Thr Asn Ala Gly Leu Pro 
1               5                   10                  15      


Pro Ser Tyr Glu Thr Ile Lys Glu Glu Tyr Gly Val Thr Glu Leu Gly 
            20                  25                  30          


Glu Pro Ser Asn Ser Ala Val Val Arg Thr Thr Val Ile Asn Met Pro 
        35                  40                  45              


Arg Glu Val Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr 
    50                  55                  60                  


Leu Phe Phe Asn Ala Cys Cys Leu Gly Phe Val Ala Tyr Ala Tyr Ser 
65                  70                  75                  80  


Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Val Gly Ala Gln 
                85                  90                  95      


Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Ser Ser Leu Ile Phe 
            100                 105                 110         


Ser Ile Leu Met Val Ile Ile Cys Ile Ile Ile Phe Ser Thr Thr Ser 
        115                 120                 125             


Val Val Val Phe Gln Ser Phe Ala Gln Arg Thr Pro His Ser Gly Phe 
    130                 135                 140                 


<210> 15
<211> 137
<212> PRT
<213> Mus sp.

<400> 15
Met Asn His Thr Ser Gln Ala Phe Ile Thr Ala Ala Ser Gly Gly Gln 
1               5                   10                  15      


Pro Pro Asn Tyr Glu Arg Ile Lys Glu Glu Tyr Glu Val Ala Glu Met 
            20                  25                  30          


Gly Ala Pro His Gly Ser Ala Ser Val Arg Thr Thr Val Ile Asn Met 
        35                  40                  45              


Pro Arg Glu Val Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn 
    50                  55                  60                  


Thr Leu Phe Met Asn Phe Cys Cys Leu Gly Phe Ile Ala Tyr Ala Tyr 
65                  70                  75                  80  


Ser Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala 
                85                  90                  95      


Gln Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Ser Thr Leu Val 
            100                 105                 110         


Leu Ser Ile Leu Met Val Val Ile Thr Ile Val Ser Val Ile Ile Ile 
        115                 120                 125             


Val Leu Asn Ala Gln Asn Leu His Thr 
    130                 135         


<210> 16
<211> 106
<212> PRT
<213> Mus sp.

<400> 16
Met Pro Lys Glu Gln Gln Glu Val Val Val Leu Gly Ser Pro His Ile 
1               5                   10                  15      


Ser Thr Ser Ala Thr Ala Thr Thr Ile Asn Met Pro Glu Ile Ser Thr 
            20                  25                  30          


Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Met Asn Phe 
        35                  40                  45              


Cys Cys Leu Gly Phe Val Ala Tyr Ala Tyr Ser Val Lys Ser Arg Asp 
    50                  55                  60                  


Arg Lys Met Val Gly Asp Thr Thr Gly Ala Gln Ala Phe Ala Ser Thr 
65                  70                  75                  80  


Ala Lys Cys Leu Asn Ile Ser Ser Leu Phe Phe Thr Ile Leu Thr Ala 
                85                  90                  95      


Ile Val Val Ile Val Val Cys Ala Ile Arg 
            100                 105     


<210> 17
<211> 104
<212> PRT
<213> Mus sp.

<400> 17
Met Val Lys Arg Asp Pro Asp Ser Ala Pro Val Pro Ser Thr Val Val 
1               5                   10                  15      


Cys Ile Asn Ser Asp Val Ile Gln Pro Asp His Ile Thr Trp Ser Thr 
            20                  25                  30          


Phe Asn Thr Val Phe Met Asn Gly Cys Cys Leu Gly Phe Ile Ala Tyr 
        35                  40                  45              


Ile Tyr Ser Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Met Thr 
    50                  55                  60                  


Gly Ala Gln Ser His Ala Ser Thr Ala Lys Ile Leu Asn Ile Leu Ala 
65                  70                  75                  80  


Leu Val Ile Ser Leu Ile Phe Tyr Ile Met Leu Ile Val Leu Tyr Ser 
                85                  90                  95      


Phe Asn Leu Leu Gly Asn Gln Arg 
            100                 


<210> 18
<211> 134
<212> PRT
<213> Mus sp.

<400> 18
Met Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser Arg 
1               5                   10                  15      


Lys Ala Asp Ala Ala Ala His Thr Ala Leu Ser Met Gly Thr Pro Gly 
            20                  25                  30          


Pro Thr Pro Arg Asp His Met Leu Trp Ser Val Phe Ser Thr Met Tyr 
        35                  40                  45              


Leu Asn Leu Cys Cys Leu Gly Phe Leu Ala Leu Val His Ser Val Lys 
    50                  55                  60                  


Ala Arg Asp Gln Lys Met Ala Gly Asn Leu Glu Ala Ala Arg Gln Tyr 
65                  70                  75                  80  


Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu 
                85                  90                  95      


Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His 
            100                 105                 110         


Leu Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe 
        115                 120                 125             


Asp Glu Glu Asp Tyr Asn 
    130                 


<210> 19
<211> 69
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (37)..(69)

<400> 19
accagtctga gtgtggaaga gacggcgctg gaaccc atg gac acg gcg tat ccc         54
                                        Met Asp Thr Ala Tyr Pro           
                                        1               5                 

cgc gag gac acc cgg                                                     69
Arg Glu Asp Thr Arg                                                       
            10                                                            


<210> 20
<211> 11
<212> PRT
<213> Homo sapiens

<400> 20
Met Asp Thr Ala Tyr Pro Arg Glu Asp Thr Arg 
1               5                   10      


<210> 21
<211> 69
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (22)..(69)

<400> 21
accagtctga gtgtggaaga g atg gcg ctg gaa ccc atg gac acg gcg tat         51
                        Met Ala Leu Glu Pro Met Asp Thr Ala Tyr           
                        1               5                   10            

ccc cgc gag gac acc cgg                                                 69
Pro Arg Glu Asp Thr Arg                                                   
                15                                                        


<210> 22
<211> 16
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Leu Glu Pro Met Asp Thr Ala Tyr Pro Arg Glu Asp Thr Arg 
1               5                   10                  15      


<210> 23
<211> 134
<212> PRT
<213> Mus sp.

<400> 23
Met Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser Arg 
1               5                   10                  15      


Lys Ala Asp Ala Ala Ala His Thr Ala Leu Ser Met Gly Thr Pro Gly 
            20                  25                  30          


Pro Thr Pro Arg Asp His Met Leu Trp Ser Val Phe Ser Thr Met Tyr 
        35                  40                  45              


Leu Asn Leu Gly Cys Leu Gly Phe Leu Ala Leu Val His Ser Val Lys 
    50                  55                  60                  


Ala Arg Asp Gln Lys Met Ala Gly Asn Leu Glu Ala Ala Arg Gln Tyr 
65                  70                  75                  80  


Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu 
                85                  90                  95      


Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His 
            100                 105                 110         


Leu Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe 
        115                 120                 125             


Asp Glu Glu Asp Tyr Asn 
    130                 


<210> 24
<211> 134
<212> PRT
<213> Mus sp.

<400> 24
Met Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser Arg 
1               5                   10                  15      


Lys Ala Asp Ala Ala Ala His Thr Ala Leu Ser Met Gly Thr Pro Gly 
            20                  25                  30          


Pro Thr Pro Arg Asp His Met Leu Trp Ser Val Phe Ser Thr Met Tyr 
        35                  40                  45              


Leu Asn Leu Cys Gly Leu Gly Phe Leu Ala Leu Val His Ser Val Lys 
    50                  55                  60                  


Ala Arg Asp Gln Lys Met Ala Gly Asn Leu Glu Ala Ala Arg Gln Tyr 
65                  70                  75                  80  


Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu 
                85                  90                  95      


Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His 
            100                 105                 110         


Leu Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe 
        115                 120                 125             


Asp Glu Glu Asp Tyr Asn 
    130                 


<210> 25
<211> 134
<212> PRT
<213> Mus sp.

<400> 25
Met Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser Arg 
1               5                   10                  15      


Lys Ala Asp Ala Ala Ala His Thr Ala Leu Ser Met Gly Thr Pro Gly 
            20                  25                  30          


Pro Thr Pro Arg Asp His Met Leu Trp Ser Val Phe Ser Thr Met Tyr 
        35                  40                  45              


Leu Asn Leu Cys Cys Leu Gly Phe Leu Ala Leu Val His Ser Val Lys 
    50                  55                  60                  


Ala Arg Asp Gln Lys Met Ala Gly Asn Leu Glu Ala Ala Arg Gln Tyr 
65                  70                  75                  80  


Gly Ser Lys Ala Lys Gly Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu 
                85                  90                  95      


Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His 
            100                 105                 110         


Leu Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe 
        115                 120                 125             


Asp Glu Glu Asp Tyr Asn 
    130                 


<210> 26
<211> 134
<212> PRT
<213> Mus sp.

<400> 26
Met Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser Arg 
1               5                   10                  15      


Lys Ala Asp Ala Ala Ala His Thr Ala Leu Ser Met Gly Thr Pro Gly 
            20                  25                  30          


Pro Thr Pro Arg Asp His Met Leu Trp Ser Val Phe Ser Thr Met Tyr 
        35                  40                  45              


Leu Asn Leu Gly Gly Leu Gly Phe Leu Ala Leu Val His Ser Val Lys 
    50                  55                  60                  


Ala Arg Asp Gln Lys Met Ala Gly Asn Leu Glu Ala Ala Arg Gln Tyr 
65                  70                  75                  80  


Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu 
                85                  90                  95      


Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His 
            100                 105                 110         


Leu Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe 
        115                 120                 125             


Asp Glu Glu Asp Tyr Asn 
    130                 


<210> 27
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(13)
<223> a, c, t, g, unknown or other

<400> 27
gaccacccac nnng                                                         14


<210> 28
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(13)
<223> a, c, t, g, unknown or other

<400> 28
gaccacccag nnng                                                         14


<210> 29
<211> 14
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (11)..(13)
<223> a, c, t, g, unknown or other

<400> 29
gaccaggcag nnng                                                         14


<210> 30
<211> 139
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Leu Glu Pro Met Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg 
1               5                   10                  15      


Ala Pro Ser Ser Arg Lys Ala Asp Ala Ala Ala His Thr Ala Leu Ser 
            20                  25                  30          


Met Gly Thr Pro Gly Pro Thr Pro Arg Asp His Met Leu Trp Ser Val 
        35                  40                  45              


Phe Ser Thr Met Tyr Leu Asn Leu Cys Cys Leu Gly Phe Leu Ala Leu 
    50                  55                  60                  


Val His Ser Val Lys Ala Arg Asp Gln Lys Met Ala Gly Asn Leu Glu 
65                  70                  75                  80  


Ala Ala Arg Gln Tyr Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala 
                85                  90                  95      


Ala Met Trp Thr Leu Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val 
            100                 105                 110         


Thr Gly Ala Leu His Leu Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe 
        115                 120                 125             


Phe Ser Thr Lys Phe Asp Glu Glu Asp Tyr Asn 
    130                 135                 


<210> 31
<211> 33
<212> PRT
<213> Homo sapiens

<400> 31
Leu Leu Gly Leu Val Val Thr Gly Ala Leu His Leu Ser Lys Leu Ala 
1               5                   10                  15      


Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe Asp Glu Glu Asp Tyr 
            20                  25                  30          


Asn 
    


<210> 32
<211> 33
<212> PRT
<213> Homo sapiens

<400> 32
Leu Leu Gly Leu Val Val Thr Gly Ala Leu His Leu Ser Lys Leu Ala 
1               5                   10                  15      


Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe Asp Glu Lys Asp Glu 
            20                  25                  30          


Leu 
    


<210> 33
<211> 42
<212> DNA
<213> Mus sp.


<220>
<221> CDS
<222> (25)..(42)

<400> 33
taggaagaca cggcgctgga accc atg gac act tca tat ccc                      42
                           Met Asp Thr Ser Tyr Pro                        
                           1               5                              


<210> 34
<211> 6
<212> PRT
<213> Mus sp.

<400> 34
Met Asp Thr Ser Tyr Pro 
1               5       


<210> 35
<211> 42
<212> DNA
<213> Mus sp.


<220>
<221> CDS
<222> (10)..(42)

<400> 35
taggaagac atg gcg ctg gaa ccc atg gac act tca tat ccc                   42
          Met Ala Leu Glu Pro Met Asp Thr Ser Tyr Pro                     
          1               5                   10                          


<210> 36
<211> 11
<212> PRT
<213> Mus sp.

<400> 36
Met Ala Leu Glu Pro Met Asp Thr Ser Tyr Pro 
1               5                   10      


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ser Thr Met Tyr Leu Asn Leu Cys Cys Leu Gly Phe Leu Ala Leu 
1               5                   10                  15  


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Thr Met Tyr Leu Asn Leu Cys Cys Leu Gly Phe Leu Ala Leu Val 
1               5                   10                  15  


<210> 39
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gln Tyr Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met 
1               5                   10                  15  


<210> 40
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Asp Thr Ser Tyr Pro Arg Glu Asp Pro Arg Ala Pro Ser Ser Arg 
1               5                   10                  15      


Lys Ala Asp Ala Ala Asn His Thr Ala Leu Ser Met Gly Thr Pro Gly 
            20                  25                  30          


Pro Thr Pro Arg Asp His Met Leu Trp Ser Val Phe Ser Thr Met Tyr 
        35                  40                  45              


Leu Asn Leu Cys Cys Leu Gly Phe Leu Ala Leu Val His Ser Val Lys 
    50                  55                  60                  


Ala Arg Asp Gln Lys Met Ala Gly Asn Leu Glu Ala Ala Arg Gln Tyr 
65                  70                  75                  80  


Gly Ser Lys Ala Lys Cys Tyr Asn Ile Leu Ala Ala Met Trp Thr Leu 
                85                  90                  95      


Val Pro Pro Leu Leu Leu Leu Gly Leu Val Val Thr Gly Ala Leu His 
            100                 105                 110         


Leu Ser Lys Leu Ala Lys Asp Ser Ala Ala Phe Phe Ser Thr Lys Phe 
        115                 120                 125             


Asp Glu Glu Asp Tyr Asn 
    130                 


