                         SEQUENCE LISTING

<110>  UNIVERSITY OF SOUTHERN CALIFORNIA
 
<120>  USE OF IKK EPSILON INHIBITORS TO ACTIVATE NFAT AND T CELL 
       RESPONSE

<130>  029680-9017-WO00

<140>  New PCT International Patent Application
<141>  2014-11-07

<150>  US 61/901,339
<151>  2013-11-07

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (IKK shRNA 77)

<400>  1
ccggctggac gatgatgaga agtttctcga gaaacttctc atcatcgtcc agttttt          57


<210>  2
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (IKK shRNA 78)

<400>  2
ccggagaagt tcgtctcggt ctatgctcga gcatagaccg agacgaactt cttttttg         58


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Mouse B-Actin)

<400>  3
tctacgaggg ctatgctctc c                                                 21


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Mouse B-Actin)

<400>  4
tctttgatgt cacgcacgat ttc                                               23


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Mouse IL-2)

<400>  5
cctgagcagg atggagaatt aca                                               23


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Mouse IL-2)

<400>  6
tccagaacat gccgcagag                                                    19


<210>  7
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Human B-Actin)

<400>  7
gcacagagcc tcgcctt                                                      17


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Human B-Actin)

<400>  8
gttgtcgacg acgagcg                                                      17


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Human IL-2)

<400>  9
aactcaccag gatgctcaca ttta                                              24


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for Human IL-2)

<400>  10
tccctgggtc ttaagtgaaa gttt                                              24


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for ORF57)

<400>  11
ccgactacac gcaacacaac                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for ORF57)

<400>  12
aaataacctg ggtgctgtca c                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for RTA)

<400>  13
tttatcagca cgccatcaac                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for RTA)

<400>  14
tgcggaacag gtgtgattat c                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for B-Actin)

<400>  15
caggcattgt gatggactcc                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide (q-PCR primer for B-Actin)

<400>  16
caagaaggaa ggctggaaaa g                                                 21


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Major histocompatibility complex (MHC)/peptide
       tetramers for yHV68 ORF61 524-531/Kb)

<400>  17

Thr Ser Ile Asn Phe Val Lys Ile 
1               5               


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Major histocompatibility complex (MHC)/peptide
       tetramers for influenza virus NP 366-374/Db)

<400>  18

Ala Ser Asn Glu Asn Met Glu Thr Met 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (NFAT conserved serine-rich motif, polypeptide)

<400>  19

Ser Val Thr Asp Asp Ser Trp Leu Gly 
1               5                   


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (NFAT epitope)

<400>  20

Ser Pro Arg Ile Glu Ile Thr 
1               5           


<210>  21
<211>  716
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gln Ser Thr Ala Asn Tyr Leu Trp His Thr Asp Asp Leu Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Ser Val Tyr Lys Ala Arg Asn Lys Lys Ser Gly 
            20                  25                  30          


Glu Leu Val Ala Val Lys Val Phe Asn Thr Thr Ser Tyr Leu Arg Pro 
        35                  40                  45              


Arg Glu Val Gln Val Arg Glu Phe Glu Val Leu Arg Lys Leu Asn His 
    50                  55                  60                  


Gln Asn Ile Val Lys Leu Phe Ala Val Glu Glu Thr Gly Gly Ser Arg 
65                  70                  75                  80  


Gln Lys Val Leu Val Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser 
                85                  90                  95      


Val Leu Glu Ser Pro Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe 
            100                 105                 110         


Leu Val Val Leu Arg Cys Val Val Ala Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu 
    130                 135                 140                 


Val Gly Glu Glu Gly Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Asp Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Pro Gln Gln Lys Ala Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Leu Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe 
    210                 215                 220                 


Gly Gly Pro Arg Arg Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu 
225                 230                 235                 240 


Lys Pro Ala Gly Ala Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro 
                245                 250                 255     


Leu Glu Trp Ser Tyr Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly 
            260                 265                 270         


Leu Gln Ser Gln Leu Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu 
        275                 280                 285             


Gln Ala Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu Gln Arg Val Val Val His Val Phe Ser Leu Ser Gln Ala Val 
305                 310                 315                 320 


Leu His His Ile Tyr Ile His Ala His Asn Thr Ile Ala Ile Phe Gln 
                325                 330                 335     


Glu Ala Val His Lys Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr 
            340                 345                 350         


Leu Phe Glu Gly His Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln 
        355                 360                 365             


His Ile Ala His Thr Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr 
    370                 375                 380                 


Ala Ile Pro Lys Gly Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro 
385                 390                 395                 400 


Lys Phe Val Pro Lys Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys 
                405                 410                 415     


Gly Val Leu Gly Ala Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu 
            420                 425                 430         


Leu Asp Gly Gln Glu Leu Met Phe Arg Gly Leu His Trp Val Met Glu 
        435                 440                 445             


Val Leu Gln Ala Thr Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser 
    450                 455                 460                 


Leu Leu Tyr Leu Ser Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val 
465                 470                 475                 480 


Ala Gly Thr Pro Glu Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg 
                485                 490                 495     


Ser Arg Leu Arg Thr Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn 
            500                 505                 510         


Ile Thr Glu Thr Gln Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val 
        515                 520                 525             


Lys Ser Arg Asp Gln Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln 
    530                 535                 540                 


Cys Cys Leu Asp Lys Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser 
545                 550                 555                 560 


Arg Met Arg Pro Gly Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu 
                565                 570                 575     


Asp Lys Val Asn Phe Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe 
            580                 585                 590         


Gln Glu Glu Cys Val Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly 
        595                 600                 605             


Lys Arg Met Arg Val Val His Glu Thr Arg Asn His Leu Arg Leu Val 
    610                 615                 620                 


Gly Cys Ser Val Ala Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu 
625                 630                 635                 640 


Ser Leu Ser Lys Leu Leu Glu Glu Leu Ser His Gln Leu Leu Gln Asp 
                645                 650                 655     


Arg Ala Lys Gly Ala Gln Ala Ser Pro Pro Pro Ile Ala Pro Tyr Pro 
            660                 665                 670         


Ser Pro Thr Arg Lys Asp Leu Leu Leu His Met Gln Glu Leu Cys Glu 
        675                 680                 685             


Gly Met Lys Leu Leu Ala Ser Asp Leu Leu Asp Asn Asn Arg Ile Ile 
    690                 695                 700                 


Glu Arg Leu Asn Arg Val Pro Ala Pro Pro Asp Val 
705                 710                 715     


<210>  22
<211>  2151
<212>  DNA
<213>  Homo sapiens

<400>  22
atgcagagca cagccaatta cctgtggcac acagatgacc tgctggggca gggggccact       60

gccagtgtgt acaaggcccg caacaagaaa tccggagagc tggttgctgt gaaggtcttc      120

aacactacca gctacctgcg gccccgcgag gtgcaggtga gggagtttga ggtcctgcgg      180

aagctgaacc accagaacat tgtcaagctc tttgcggtgg aggagacggg cggaagccgg      240

cagaaggtac tggtgatgga gtactgctcc agtgggagcc tgctgagtgt gctggagagc      300

cctgagaatg cctttgggct gcctgaggat gagttcctgg tggtgctgcg ctgtgtggtg      360

gccggcatga accacctgcg ggagaacggc attgtgcatc gcgacatcaa gccggggaac      420

atcatgcgcc tcgtagggga ggaggggcag agcatctaca agctgacaga cttcggcgct      480

gcccgggagc tggatgatga tgagaagttc gtctcggtct atgggactga ggagtacctg      540

catcccgaca tgtatgagcg ggcggtgctt cgaaagcccc agcaaaaagc gttcggggtg      600

actgtggatc tctggagcat tggagtgacc ttgtaccatg cagccactgg cagcctgccc      660

ttcatcccct ttggtgggcc acggcggaac aaggagatca tgtaccggat caccacggag      720

aagccggctg gggccattgc aggtgcccag aggcgggaga acgggcccct ggagtggagc      780

tacaccctcc ccatcacctg ccagctgtca ctggggctgc agagccagct ggtgcccatc      840

ctggccaaca tcctggaggt ggagcaggcc aagtgctggg gcttcgacca gttctttgcg      900

gagaccagtg acatcctgca gcgagttgtc gtccatgtct tctccctgtc ccaggcagtc      960

ctgcaccaca tctatatcca tgcccacaac acgatagcca ttttccagga ggccgtgcac     1020

aagcagacca gtgtggcccc ccgacaccag gagtacctct ttgagggtca cctctgtgtc     1080

ctcgagccca gcgtctcagc acagcacatc gcccacacga cggcaagcag ccccctgacc     1140

ctcttcagca cagccatccc taaggggctg gccttcaggg accctgctct ggacgtcccc     1200

aagttcgtcc ccaaagtgga cctgcaggcg gattacaaca ctgccaaggg cgtgttgggc     1260

gccggctacc aggccctgcg gctggcacgg gccctgctgg atgggcagga gctaatgttt     1320

cgggggctgc actgggtcat ggaggtgctc caggccacat gcagacggac tctggaagtg     1380

gcaaggacat ccctcctcta cctcagcagc agcctgggaa ctgagaggtt cagcagcgtg     1440

gctggaacgc ctgagatcca ggaactgaag gcggctgcag aactgaggtc caggctgcgg     1500

actctagcgg aggtcctctc cagatgctcc caaaatatca cggagaccca ggagagcctg     1560

agcagcctga accgggagct ggtgaagagc cgggatcagg tacatgagga cagaagcatc     1620

cagcagattc agtgctgttt ggacaagatg aacttcatct acaaacagtt caagaagtct     1680

aggatgaggc cagggcttgg ctacaacgag gagcagattc acaagctgga taaggtgaat     1740

ttcagtcatt tagccaaaag actcctgcag gtgttccagg aggagtgcgt gcagaagtat     1800

caagcgtcct tagtcacaca cggcaagagg atgagggtgg tgcacgagac caggaaccac     1860

ctgcgcctgg ttggctgttc tgtggctgcc tgtaacacag aagcccaggg ggtccaggag     1920

agtctcagca agctcctgga agagctatct caccagctcc ttcaggaccg agcaaagggg     1980

gctcaggcct cgccgcctcc catagctcct taccccagcc ctacacgaaa ggacctgctt     2040

ctccacatgc aagagctctg cgaggggatg aagctgctgg catctgacct cctggacaac     2100

aaccgcatca tcgaacggct aaatagagtc ccagcacctc ctgatgtctg a              2151


<210>  23
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gln Ser Thr Ala Asn Tyr Leu Trp His Thr Asp Asp Leu Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Ser Val Tyr Lys Ala Arg Asn Lys Lys Ser Gly 
            20                  25                  30          


Glu Leu Val Ala Val Lys Val Phe Asn Thr Thr Ser Tyr Leu Arg Pro 
        35                  40                  45              


Arg Glu Val Gln Val Arg Glu Phe Glu Val Leu Arg Lys Leu Asn His 
    50                  55                  60                  


Gln Asn Ile Val Lys Leu Phe Ala Val Glu Glu Thr Gly Gly Ser Arg 
65                  70                  75                  80  


Gln Lys Val Leu Val Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser 
                85                  90                  95      


Val Leu Glu Ser Pro Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe 
            100                 105                 110         


Leu Val Val Leu Arg Cys Val Val Ala Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu 
    130                 135                 140                 


Val Gly Glu Glu Gly Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Asp Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Pro Gln Gln Lys Ala Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Leu Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe 
    210                 215                 220                 


Gly Gly Pro Arg Arg Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu 
225                 230                 235                 240 


Lys Pro Ala Gly Ala Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro 
                245                 250                 255     


Leu Glu Trp Ser Tyr Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly 
            260                 265                 270         


Leu Gln Ser Gln Leu Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu 
        275                 280                 285             


Gln Ala Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu Gln Arg Val Val Val His Val Phe Ser Leu Ser Gln Ala Val 
305                 310                 315                 320 


Leu His His Ile Tyr Ile His Ala His Asn Thr Ile Ala Ile Phe Gln 
                325                 330                 335     


Glu Ala Val His Lys Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr 
            340                 345                 350         


Leu Phe Glu Gly His Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln 
        355                 360                 365             


His Ile Ala His Thr Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr 
    370                 375                 380                 


Ala Ile Pro Lys Gly Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro 
385                 390                 395                 400 


Lys Phe Val Pro Lys Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys 
                405                 410                 415     


Gly Val Leu Gly Ala Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu 
            420                 425                 430         


Leu Asp Gly Gln Glu Leu Met Phe Arg Gly Leu His Trp Val Met Glu 
        435                 440                 445             


Val Leu Gln Ala Thr Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser 
    450                 455                 460                 


Leu Leu Tyr Leu Ser Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val 
465                 470                 475                 480 


Ala Gly Thr Pro Glu Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg 
                485                 490                 495     


Ser Arg Leu Arg Thr Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn 
            500                 505                 510         


Ile Thr Glu Thr Gln Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val 
        515                 520                 525             


Lys Ser Arg Asp Gln Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln 
    530                 535                 540                 


Cys Cys Leu Asp Lys Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser 
545                 550                 555                 560 


Arg Met Arg Pro Gly Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu 
                565                 570                 575     


Asp Lys Val Asn Phe Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe 
            580                 585                 590         


Gln Glu Glu Cys Val Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly 
        595                 600                 605             


Lys Arg Met Arg Val Val His Glu Thr Arg Asn His Leu Arg Leu Val 
    610                 615                 620                 


Gly Cys Ser Val Ala Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu 
625                 630                 635                 640 


Ser Leu Ser Lys His Ala Arg Ala Leu Arg Gly Asp Glu Ala Ala Gly 
                645                 650                 655     


Ile 
    


<210>  24
<211>  1974
<212>  DNA
<213>  Homo sapiens

<400>  24
atgcagagca cagccaatta cctgtggcac acagatgacc tgctggggca gggggccact       60

gccagtgtgt acaaggcccg caacaagaaa tccggagagc tggttgctgt gaaggtcttc      120

aacactacca gctacctgcg gccccgcgag gtgcaggtga gggagtttga ggtcctgcgg      180

aagctgaacc accagaacat tgtcaagctc tttgcggtgg aggagacggg cggaagccgg      240

cagaaggtac tggtgatgga gtactgctcc agtgggagcc tgctgagtgt gctggagagc      300

cctgagaatg cctttgggct gcctgaggat gagttcctgg tggtgctgcg ctgtgtggtg      360

gccggcatga accacctgcg ggagaacggc attgtgcatc gcgacatcaa gccggggaac      420

atcatgcgcc tcgtagggga ggaggggcag agcatctaca agctgacaga cttcggcgct      480

gcccgggagc tggatgatga tgagaagttc gtctcggtct atgggactga ggagtacctg      540

catcccgaca tgtatgagcg ggcggtgctt cgaaagcccc agcaaaaagc gttcggggtg      600

actgtggatc tctggagcat tggagtgacc ttgtaccatg cagccactgg cagcctgccc      660

ttcatcccct ttggtgggcc acggcggaac aaggagatca tgtaccggat caccacggag      720

aagccggctg gggccattgc aggtgcccag aggcgggaga acgggcccct ggagtggagc      780

tacaccctcc ccatcacctg ccagctgtca ctggggctgc agagccagct ggtgcccatc      840

ctggccaaca tcctggaggt ggagcaggcc aagtgctggg gcttcgacca gttctttgcg      900

gagaccagtg acatcctgca gcgagttgtc gtccatgtct tctccctgtc ccaggcagtc      960

ctgcaccaca tctatatcca tgcccacaac acgatagcca ttttccagga ggccgtgcac     1020

aagcagacca gtgtggcccc ccgacaccag gagtacctct ttgagggtca cctctgtgtc     1080

ctcgagccca gcgtctcagc acagcacatc gcccacacga cggcaagcag ccccctgacc     1140

ctcttcagca cagccatccc taaggggctg gccttcaggg accctgctct ggacgtcccc     1200

aagttcgtcc ccaaagtgga cctgcaggcg gattacaaca ctgccaaggg cgtgttgggc     1260

gccggctacc aggccctgcg gctggcacgg gccctgctgg atgggcagga gctaatgttt     1320

cgggggctgc actgggtcat ggaggtgctc caggccacat gcagacggac tctggaagtg     1380

gcaaggacat ccctcctcta cctcagcagc agcctgggaa ctgagaggtt cagcagcgtg     1440

gctggaacgc ctgagatcca ggaactgaag gcggctgcag aactgaggtc caggctgcgg     1500

actctagcgg aggtcctctc cagatgctcc caaaatatca cggagaccca ggagagcctg     1560

agcagcctga accgggagct ggtgaagagc cgggatcagg tacatgagga cagaagcatc     1620

cagcagattc agtgctgttt ggacaagatg aacttcatct acaaacagtt caagaagtct     1680

aggatgaggc cagggcttgg ctacaacgag gagcagattc acaagctgga taaggtgaat     1740

ttcagtcatt tagccaaaag actcctgcag gtgttccagg aggagtgcgt gcagaagtat     1800

caagcgtcct tagtcacaca cggcaagagg atgagggtgg tgcacgagac caggaaccac     1860

ctgcgcctgg ttggctgttc tgtggctgcc tgtaacacag aagcccaggg ggtccaggag     1920

agtctcagca agcatgcaag agctctgcga ggggatgaag ctgctggcat ctga           1974


<210>  25
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Tyr Cys Ser Ser Gly Ser Leu Leu Ser Val Leu Glu Ser Pro 
1               5                   10                  15      


Glu Asn Ala Phe Gly Leu Pro Glu Asp Glu Phe Leu Val Val Leu Arg 
            20                  25                  30          


Cys Val Val Ala Gly Met Asn His Leu Arg Glu Asn Gly Ile Val His 
        35                  40                  45              


Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Leu Val Gly Glu Glu Gly 
    50                  55                  60                  


Gln Ser Ile Tyr Lys Leu Thr Asp Phe Gly Ala Ala Arg Glu Leu Asp 
65                  70                  75                  80  


Asp Asp Glu Lys Phe Val Ser Val Tyr Gly Thr Glu Glu Tyr Leu His 
                85                  90                  95      


Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys Pro Gln Gln Lys Ala 
            100                 105                 110         


Phe Gly Val Thr Val Asp Leu Trp Ser Ile Gly Val Thr Leu Tyr His 
        115                 120                 125             


Ala Ala Thr Gly Ser Leu Pro Phe Ile Pro Phe Gly Gly Pro Arg Arg 
    130                 135                 140                 


Asn Lys Glu Ile Met Tyr Arg Ile Thr Thr Glu Lys Pro Ala Gly Ala 
145                 150                 155                 160 


Ile Ala Gly Ala Gln Arg Arg Glu Asn Gly Pro Leu Glu Trp Ser Tyr 
                165                 170                 175     


Thr Leu Pro Ile Thr Cys Gln Leu Ser Leu Gly Leu Gln Ser Gln Leu 
            180                 185                 190         


Val Pro Ile Leu Ala Asn Ile Leu Glu Val Glu Gln Ala Lys Cys Trp 
        195                 200                 205             


Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp Ile Leu Gln Arg Val 
    210                 215                 220                 


Val Val His Val Phe Ser Leu Ser Gln Ala Val Leu His His Ile Tyr 
225                 230                 235                 240 


Ile His Ala His Asn Thr Ile Ala Ile Phe Gln Glu Ala Val His Lys 
                245                 250                 255     


Gln Thr Ser Val Ala Pro Arg His Gln Glu Tyr Leu Phe Glu Gly His 
            260                 265                 270         


Leu Cys Val Leu Glu Pro Ser Val Ser Ala Gln His Ile Ala His Thr 
        275                 280                 285             


Thr Ala Ser Ser Pro Leu Thr Leu Phe Ser Thr Ala Ile Pro Lys Gly 
    290                 295                 300                 


Leu Ala Phe Arg Asp Pro Ala Leu Asp Val Pro Lys Phe Val Pro Lys 
305                 310                 315                 320 


Val Asp Leu Gln Ala Asp Tyr Asn Thr Ala Lys Gly Val Leu Gly Ala 
                325                 330                 335     


Gly Tyr Gln Ala Leu Arg Leu Ala Arg Ala Leu Leu Asp Gly Gln Glu 
            340                 345                 350         


Leu Met Phe Arg Gly Leu His Trp Val Met Glu Val Leu Gln Ala Thr 
        355                 360                 365             


Cys Arg Arg Thr Leu Glu Val Ala Arg Thr Ser Leu Leu Tyr Leu Ser 
    370                 375                 380                 


Ser Ser Leu Gly Thr Glu Arg Phe Ser Ser Val Ala Gly Thr Pro Glu 
385                 390                 395                 400 


Ile Gln Glu Leu Lys Ala Ala Ala Glu Leu Arg Ser Arg Leu Arg Thr 
                405                 410                 415     


Leu Ala Glu Val Leu Ser Arg Cys Ser Gln Asn Ile Thr Glu Thr Gln 
            420                 425                 430         


Glu Ser Leu Ser Ser Leu Asn Arg Glu Leu Val Lys Ser Arg Asp Gln 
        435                 440                 445             


Val His Glu Asp Arg Ser Ile Gln Gln Ile Gln Cys Cys Leu Asp Lys 
    450                 455                 460                 


Met Asn Phe Ile Tyr Lys Gln Phe Lys Lys Ser Arg Met Arg Pro Gly 
465                 470                 475                 480 


Leu Gly Tyr Asn Glu Glu Gln Ile His Lys Leu Asp Lys Val Asn Phe 
                485                 490                 495     


Ser His Leu Ala Lys Arg Leu Leu Gln Val Phe Gln Glu Glu Cys Val 
            500                 505                 510         


Gln Lys Tyr Gln Ala Ser Leu Val Thr His Gly Lys Arg Met Arg Val 
        515                 520                 525             


Val His Glu Thr Arg Asn His Leu Arg Leu Val Gly Cys Ser Val Ala 
    530                 535                 540                 


Ala Cys Asn Thr Glu Ala Gln Gly Val Gln Glu Ser Leu Ser Lys Leu 
545                 550                 555                 560 


Leu Glu Glu Leu Ser His Gln Leu Leu Gln Asp Arg Ala Lys Gly Ala 
                565                 570                 575     


Gln Ala Ser Pro Pro Pro Ile Ala Pro Tyr Pro Ser Pro Thr Arg Lys 
            580                 585                 590         


Asp Leu Leu Leu His Met Gln Glu Leu Cys Glu Gly Met Lys Leu Leu 
        595                 600                 605             


Ala Ser Asp Leu Leu Asp Asn Asn Arg Ile Ile Glu Arg Leu Asn Arg 
    610                 615                 620                 


Val Pro Ala Pro Pro Asp Val 
625                 630     


<210>  26
<211>  1896
<212>  DNA
<213>  Homo sapiens

<400>  26
atggagtact gctccagtgg gagcctgctg agtgtgctgg agagccctga gaatgccttt       60

gggctgcctg aggatgagtt cctggtggtg ctgcgctgtg tggtggccgg catgaaccac      120

ctgcgggaga acggcattgt gcatcgcgac atcaagccgg ggaacatcat gcgcctcgta      180

ggggaggagg ggcagagcat ctacaagctg acagacttcg gcgctgcccg ggagctggat      240

gatgatgaga agttcgtctc ggtctatggg actgaggagt acctgcatcc cgacatgtat      300

gagcgggcgg tgcttcgaaa gccccagcaa aaagcgttcg gggtgactgt ggatctctgg      360

agcattggag tgaccttgta ccatgcagcc actggcagcc tgcccttcat cccctttggt      420

gggccacggc ggaacaagga gatcatgtac cggatcacca cggagaagcc ggctggggcc      480

attgcaggtg cccagaggcg ggagaacggg cccctggagt ggagctacac cctccccatc      540

acctgccagc tgtcactggg gctgcagagc cagctggtgc ccatcctggc caacatcctg      600

gaggtggagc aggccaagtg ctggggcttc gaccagttct ttgcggagac cagtgacatc      660

ctgcagcgag ttgtcgtcca tgtcttctcc ctgtcccagg cagtcctgca ccacatctat      720

atccatgccc acaacacgat agccattttc caggaggccg tgcacaagca gaccagtgtg      780

gccccccgac accaggagta cctctttgag ggtcacctct gtgtcctcga gcccagcgtc      840

tcagcacagc acatcgccca cacgacggca agcagccccc tgaccctctt cagcacagcc      900

atccctaagg ggctggcctt cagggaccct gctctggacg tccccaagtt cgtccccaaa      960

gtggacctgc aggcggatta caacactgcc aagggcgtgt tgggcgccgg ctaccaggcc     1020

ctgcggctgg cacgggccct gctggatggg caggagctaa tgtttcgggg gctgcactgg     1080

gtcatggagg tgctccaggc cacatgcaga cggactctgg aagtggcaag gacatccctc     1140

ctctacctca gcagcagcct gggaactgag aggttcagca gcgtggctgg aacgcctgag     1200

atccaggaac tgaaggcggc tgcagaactg aggtccaggc tgcggactct agcggaggtc     1260

ctctccagat gctcccaaaa tatcacggag acccaggaga gcctgagcag cctgaaccgg     1320

gagctggtga agagccggga tcaggtacat gaggacagaa gcatccagca gattcagtgc     1380

tgtttggaca agatgaactt catctacaaa cagttcaaga agtctaggat gaggccaggg     1440

cttggctaca acgaggagca gattcacaag ctggataagg tgaatttcag tcatttagcc     1500

aaaagactcc tgcaggtgtt ccaggaggag tgcgtgcaga agtatcaagc gtccttagtc     1560

acacacggca agaggatgag ggtggtgcac gagaccagga accacctgcg cctggttggc     1620

tgttctgtgg ctgcctgtaa cacagaagcc cagggggtcc aggagagtct cagcaagctc     1680

ctggaagagc tatctcacca gctccttcag gaccgagcaa agggggctca ggcctcgccg     1740

cctcccatag ctccttaccc cagccctaca cgaaaggacc tgcttctcca catgcaagag     1800

ctctgcgagg ggatgaagct gctggcatct gacctcctgg acaacaaccg catcatcgaa     1860

cggctaaata gagtcccagc acctcctgat gtctga                               1896


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (SP2 serine-rich motif of NFAT, polypeptide)

<400>  27

Ser Pro Gln His Ser Pro Ser Thr Ser Pro Arg Ala Ser Val Thr Glu 
1               5                   10                  15      


Glu Ser Trp Leu Gly 
            20      


<210>  28
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (SP3 serine-rich motif of NFAT, polypeptide)

<400>  28

Ser Pro His His Ser Pro Thr Pro Ser Pro His Gly Ser Pro Arg Val 
1               5                   10                  15      


Ser Val Thr Asp Asp Ser Trp Leu Gly 
            20                  25  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (NFAT conserved serine-rich motif, polypeptide)

<400>  29

Ser Val Thr Glu Glu Ser Trp Leu Gly 
1               5                   


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Polypeptide from mass spectrometry analysis)

<400>  30

Lys Arg Ser Pro Ser Thr Ala Thr Leu Ser Leu 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Polypeptide from mass spectrometry analysis)

<400>  31

Thr Ala Thr Leu Ser Leu Pro Ser Leu Glu Ala 
1               5                   10      


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide (Polypeptide from mass spectrometry analysis)

<400>  32

Asp Ser Ser Leu Asp Leu Gly Asp Gly 
1               5                   


