                         SEQUENCE LISTING

<110>  DIGNITY HEALTH
       BOWSER, Robert
       COLLINS, Mahlon
 
<120>  NUCLEAR STRESS RESPONSE IN MOTOR NEURON DISEASE AND OTHER 
       NEUROLOGICAL DISEASES

<130>  065486-000022WO00

<150>  61/901,296
<151>  2013-11-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Glu Ala Gly Ser Ser Ala Ser Gly Gly Gly Phe Arg Pro Gly 
1               5                   10                  15      


Val Asp Ser Leu Asp Glu Pro Pro Asn Ser Arg Ile Phe Leu Val Ile 
            20                  25                  30          


Ser Lys Tyr Thr Pro Glu Ser Val Leu Arg Glu Arg Phe Ser Pro Phe 
        35                  40                  45              


Gly Asp Ile Gln Asp Ile Trp Val Val Arg Asp Lys His Thr Lys Glu 
    50                  55                  60                  


Ser Lys Gly Ile Ala Phe Val Lys Phe Ala Arg Ser Ser Gln Ala Cys 
65                  70                  75                  80  


Arg Ala Met Glu Glu Met His Gly Gln Cys Leu Gly Pro Asn Asp Thr 
                85                  90                  95      


Lys Pro Ile Lys Val Phe Ile Ala Gln Ser Arg Ser Ser Gly Ser His 
            100                 105                 110         


Arg Asp Val Glu Asp Glu Glu Leu Thr Arg Ile Phe Val Met Ile Pro 
        115                 120                 125             


Lys Ser Tyr Thr Glu Glu Asp Leu Arg Glu Lys Phe Lys Val Tyr Gly 
    130                 135                 140                 


Asp Ile Glu Tyr Cys Ser Ile Ile Lys Asn Lys Val Thr Gly Glu Ser 
145                 150                 155                 160 


Lys Gly Leu Gly Tyr Val Arg Tyr Leu Lys Pro Ser Gln Ala Ala Gln 
                165                 170                 175     


Ala Ile Glu Asn Cys Asp Arg Ser Phe Arg Ala Ile Leu Ala Glu Pro 
            180                 185                 190         


Lys Asn Lys Ala Ser Glu Ser Ser Glu Gln Asp Tyr Tyr Ser Asn Met 
        195                 200                 205             


Arg Gln Glu Ala Leu Gly His Glu Pro Arg Val Asn Met Phe Pro Phe 
    210                 215                 220                 


Glu Gln Gln Ser Glu Phe Ser Ser Phe Asp Lys Asn Asp Ser Arg Gly 
225                 230                 235                 240 


Gln Glu Ala Ile Ser Lys Arg Leu Ser Val Val Ser Arg Val Pro Phe 
                245                 250                 255     


Thr Glu Glu Gln Leu Phe Ser Ile Phe Asp Ile Val Pro Gly Leu Glu 
            260                 265                 270         


Tyr Cys Glu Val Gln Arg Asp Pro Tyr Ser Asn Tyr Gly His Gly Val 
        275                 280                 285             


Val Gln Tyr Phe Asn Val Ala Ser Ala Ile Tyr Ala Lys Tyr Lys Leu 
    290                 295                 300                 


His Gly Phe Gln Tyr Pro Pro Gly Asn Arg Ile Gly Val Ser Phe Ile 
305                 310                 315                 320 


Asp Asp Gly Ser Asn Ala Thr Asp Leu Leu Arg Lys Met Ala Thr Gln 
                325                 330                 335     


Met Val Ala Ala Gln Leu Ala Ser Met Val Trp Asn Asn Pro Ser Gln 
            340                 345                 350         


Gln Gln Phe Met Gln Phe Gly Gly Ser Ser Gly Ser Gln Leu Pro Gln 
        355                 360                 365             


Ile Gln Thr Asp Val Val Leu Pro Ser Cys Lys Lys Lys Ala Pro Ala 
    370                 375                 380                 


Glu Thr Pro Val Lys Glu Arg Leu Phe Ile Val Phe Asn Pro His Pro 
385                 390                 395                 400 


Leu Pro Leu Asp Val Leu Glu Asp Ile Phe Cys Arg Phe Gly Asn Leu 
                405                 410                 415     


Ile Glu Val Tyr Leu Val Ser Gly Lys Asn Val Gly Tyr Ala Lys Tyr 
            420                 425                 430         


Ala Asp Arg Ile Ser Ala Asn Asp Ala Ile Ala Thr Leu His Gly Lys 
        435                 440                 445             


Ile Leu Asn Gly Val Arg Leu Lys Val Met Leu Ala Asp Ser Pro Arg 
    450                 455                 460                 


Glu Glu Ser Asn Lys Arg Gln Arg Thr Tyr 
465                 470                 


<210>  2
<211>  1860
<212>  DNA
<213>  Homo sapiens

<400>  2
cgagccggca aaggcttggg tgtgagacag cagcggtggc agacaccgca gaagcaaaga       60

gcagtgaggc tcctgcattc gggtggagca ccatggacga agctggcagc tctgcgagcg      120

gcgggggctt ccgcccgggc gtggacagcc tggacgaacc gcccaacagc cgcatcttcc      180

ttgtgatcag caagtacaca cctgagtcgg tgctgaggga gcgcttctcg ccttttggcg      240

acatccagga catctgggtg gtgcgggaca agcacaccaa ggagtccaag ggcattgctt      300

tcgtcaagtt cgcccgcagc tcacaggcct gcagggccat ggaggagatg catggccagt      360

gcctcggccc caacgacacc aagcccatca aggttttcat tgctcagtcc cgatcatctg      420

gaagtcaccg agatgttgaa gatgaagaac ttacaagaat ctttgttatg ataccaaagt      480

cctacacaga agaagatctg cgggaaaaat ttaaggtgta tggagatatc gagtattgca      540

gcattattaa gaataaagtg actggagaaa gtaaaggttt gggctacgta cgatacttaa      600

aaccatcaca agctgcccaa gcaatagaaa actgtgatcg aagttttaga gcaatcttgg      660

ctgaacctaa aaataaagca tctgaatcct ctgaacaaga ttattatagt aatatgaggc      720

aagaagcttt gggacatgaa cctagagtaa atatgtttcc atttgaacaa caatctgaat      780

tttcaagttt tgacaagaat gatagccgag gccaggaagc aatctccaaa cgcttgtcag      840

ttgtatcaag agttcctttc actgaagaac agcttttcag catttttgat atagtaccag      900

gattggaata ttgtgaagtt caacgagatc cttattcaaa ttatggtcat ggagtggttc      960

agtattttaa tgtagcatca gctatttatg caaaatacaa attacatgga tttcagtacc     1020

ctcctgggaa ccgaataggt gtttccttca ttgatgatgg aagtaatgca acagatctcc     1080

ttagaaaaat ggcaacacag atggtagctg cacagcttgc atcaatggtg tggaataacc     1140

caagtcagca acaatttatg caatttggag gaagctctgg atcacagttg cctcaaatcc     1200

agacagatgt tgtacttcca tcatgcaaaa aaaaagctcc tgctgaaact cctgtgaaag     1260

aaagactttt tattgtgttt aatcctcatc ctttaccttt agacgtatta gaagatatat     1320

tctgtcgttt tggtaacctg atcgaagttt accttgtgtc aggaaaaaat gtggggtatg     1380

ccaagtatgc cgatagaata agtgctaatg atgccattgc cactctacat ggaaagattc     1440

tgaatggggt gagacttaaa gttatgctgg cagattcgcc aagagaagaa tctaacaaac     1500

ggcaaagaac ttactgattc ttgagaacaa agactaaata atgacataat cctcagctga     1560

ctgactgaaa atgtgactgg acgcattccc tgtggacagt tgacagcttt ttttttttcc     1620

atatacctga tagtctgtgt acagcattgt tttgtctggg aagcagggat tgctgacatg     1680

tatttttgaa tccatacatt aatgctaaaa cgaatatagt agttgttcct tagagcaata     1740

tgttgttacg tgtagcagaa ataaagtttt ctttgcttaa ctaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860


<210>  3
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Leu Pro Val Gly Pro Gly Ala Ala Gly Pro Ser Asn Val Pro 
1               5                   10                  15      


Ala Phe Leu Thr Lys Leu Trp Thr Leu Val Ser Asp Pro Asp Thr Asp 
            20                  25                  30          


Ala Leu Ile Cys Trp Ser Pro Ser Gly Asn Ser Phe His Val Phe Asp 
        35                  40                  45              


Gln Gly Gln Phe Ala Lys Glu Val Leu Pro Lys Tyr Phe Lys His Asn 
    50                  55                  60                  


Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe Arg Lys 
65                  70                  75                  80  


Val Val His Ile Glu Gln Gly Gly Leu Val Lys Pro Glu Arg Asp Asp 
                85                  90                  95      


Thr Glu Phe Gln His Pro Cys Phe Leu Arg Gly Gln Glu Gln Leu Leu 
            100                 105                 110         


Glu Asn Ile Lys Arg Lys Val Thr Ser Val Ser Thr Leu Lys Ser Glu 
        115                 120                 125             


Asp Ile Lys Ile Arg Gln Asp Ser Val Thr Lys Leu Leu Thr Asp Val 
    130                 135                 140                 


Gln Leu Met Lys Gly Lys Gln Glu Cys Met Asp Ser Lys Leu Leu Ala 
145                 150                 155                 160 


Met Lys His Glu Asn Glu Ala Leu Trp Arg Glu Val Ala Ser Leu Arg 
                165                 170                 175     


Gln Lys His Ala Gln Gln Gln Lys Val Val Asn Lys Leu Ile Gln Phe 
            180                 185                 190         


Leu Ile Ser Leu Val Gln Ser Asn Arg Ile Leu Gly Val Lys Arg Lys 
        195                 200                 205             


Ile Pro Leu Met Leu Asn Asp Ser Gly Ser Ala His Ser Met Pro Lys 
    210                 215                 220                 


Tyr Ser Arg Gln Phe Ser Leu Glu His Val His Gly Ser Gly Pro Tyr 
225                 230                 235                 240 


Ser Ala Pro Ser Pro Ala Tyr Ser Ser Ser Ser Leu Tyr Ala Pro Asp 
                245                 250                 255     


Ala Val Ala Ser Ser Gly Pro Ile Ile Ser Asp Ile Thr Glu Leu Ala 
            260                 265                 270         


Pro Ala Ser Pro Met Ala Ser Pro Gly Gly Ser Ile Asp Glu Arg Pro 
        275                 280                 285             


Leu Ser Ser Ser Pro Leu Val Arg Val Lys Glu Glu Pro Pro Ser Pro 
    290                 295                 300                 


Pro Gln Ser Pro Arg Val Glu Glu Ala Ser Pro Gly Arg Pro Ser Ser 
305                 310                 315                 320 


Val Asp Thr Leu Leu Ser Pro Thr Ala Leu Ile Asp Ser Ile Leu Arg 
                325                 330                 335     


Glu Ser Glu Pro Ala Pro Ala Ser Val Thr Ala Leu Thr Asp Ala Arg 
            340                 345                 350         


Gly His Thr Asp Thr Glu Gly Arg Pro Pro Ser Pro Pro Pro Thr Ser 
        355                 360                 365             


Thr Pro Glu Lys Cys Leu Ser Val Ala Cys Leu Asp Lys Asn Glu Leu 
    370                 375                 380                 


Ser Asp His Leu Asp Ala Met Asp Ser Asn Leu Asp Asn Leu Gln Thr 
385                 390                 395                 400 


Met Leu Ser Ser His Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp 
                405                 410                 415     


Leu Phe Ser Pro Ser Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu 
            420                 425                 430         


Asp Ser Ser Leu Ala Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro 
        435                 440                 445             


Pro Arg Pro Pro Glu Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln 
    450                 455                 460                 


Leu Val His Tyr Thr Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser 
465                 470                 475                 480 


Val Asp Thr Gly Ser Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu 
                485                 490                 495     


Gly Ser Tyr Phe Ser Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile 
            500                 505                 510         


Ser Leu Leu Thr Gly Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val 
        515                 520                 525             


Ser 
    


<210>  4
<211>  2166
<212>  DNA
<213>  Homo sapiens

<400>  4
gcggcgggag cgcgcccgtt gcaagatggc ggcggccatg ctgggccccg gggctgtgtg       60

tgcgcagcgg gcggcggcgc ggcccggaag gctggcgcgg cgacggcgtt agcccggccc      120

tcggcccctc tttgcggccg ctccctccgc ctattccctc cttgctcgag atggatctgc      180

ccgtgggccc cggcgcggcg gggcccagca acgtcccggc cttcctgacc aagctgtgga      240

ccctcgtgag cgacccggac accgacgcgc tcatctgctg gagcccgagc gggaacagct      300

tccacgtgtt cgaccagggc cagtttgcca aggaggtgct gcccaagtac ttcaagcaca      360

acaacatggc cagcttcgtg cggcagctca acatgtatgg cttccggaaa gtggtccaca      420

tcgagcaggg cggcctggtc aagccagaga gagacgacac ggagttccag cacccatgct      480

tcctgcgtgg ccaggagcag ctccttgaga acatcaagag gaaagtgacc agtgtgtcca      540

ccctgaagag tgaagacata aagatccgcc aggacagcgt caccaagctg ctgacggacg      600

tgcagctgat gaaggggaag caggagtgca tggactccaa gctcctggcc atgaagcatg      660

agaatgaggc tctgtggcgg gaggtggcca gccttcggca gaagcatgcc cagcaacaga      720

aagtcgtcaa caagctcatt cagttcctga tctcactggt gcagtcaaac cggatcctgg      780

gggtgaagag aaagatcccc ctgatgctga acgacagtgg ctcagcacat tccatgccca      840

agtatagccg gcagttctcc ctggagcacg tccacggctc gggcccctac tcggccccct      900

ccccagccta cagcagctcc agcctctacg cccctgatgc tgtggccagc tctggaccca      960

tcatctccga catcaccgag ctggctcctg ccagccccat ggcctccccc ggcgggagca     1020

tagacgagag gcccctatcc agcagccccc tggtgcgtgt caaggaggag ccccccagcc     1080

cgcctcagag cccccgggta gaggaggcga gtcccgggcg cccatcttcc gtggacaccc     1140

tcttgtcccc gaccgccctc attgactcca tcctgcggga gagtgaacct gcccccgcct     1200

ccgtcacagc cctcacggac gccaggggcc acacggacac cgagggccgg cctccctccc     1260

ccccgcccac ctccacccct gaaaagtgcc tcagcgtagc ctgcctggac aagaatgagc     1320

tcagtgacca cttggatgct atggactcca acctggataa cctgcagacc atgctgagca     1380

gccacggctt cagcgtggac accagtgccc tgctggacct gttcagcccc tcggtgaccg     1440

tgcccgacat gagcctgcct gaccttgaca gcagcctggc cagtatccaa gagctcctgt     1500

ctccccagga gccccccagg cctcccgagg cagagaacag cagcccggat tcagggaagc     1560

agctggtgca ctacacagcg cagccgctgt tcctgctgga ccccggctcc gtggacaccg     1620

ggagcaacga cctgccggtg ctgtttgagc tgggagaggg ctcctacttc tccgaagggg     1680

acggcttcgc cgaggacccc accatctccc tgctgacagg ctcggagcct cccaaagcca     1740

aggaccccac tgtctcctag aggccccgga ggagctgggc cagccgccca cccccacccc     1800

cagtgcaggg ctggtcttgg ggaggcaggg cagcctcgcg gtcttgggca ctggtgggtc     1860

ggccgccata gccccagtag gacaaacggg ctcgggtctg ggcagcacct ctggtcagga     1920

gggtcaccct ggcctgccag tctgccttcc cccaaccccg tgtcctgtgg tttggttggg     1980

gcttcacagc cacacctgga ctgaccctgc aggttgttca tagtcagaat tgtattttgg     2040

atttttacac aactgtcccg ttccccgctc cacagagata cacagatata tacacacagt     2100

ggatggacgg acaagacagg cagagatcta taaacagaca ggctctatgc taaaaaaaaa     2160

aaaaaa                                                                2166


