                         SEQUENCE LISTING

<110>  UCB Biopharma SPRL
 
<120>  FcRn Antibody

<130>  G0191

<150>  GB1320066.2
<151>  2013-11-13

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  1

Gly Phe Ser Leu Ser Thr Tyr Gly Val Gly Val Gly 
1               5                   10          


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  2

Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Glu Asn 
1               5                   10                  15      


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  3

Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
1               5                   10              


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  4

Arg Thr Ser Glu Asp Ile Tyr Thr Asn Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  5

Val Ala Lys Thr Leu Gln Asp 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  6

Leu Gln Gly Phe Lys Phe Pro Trp Thr 
1               5                   


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 VARIANT

<400>  7

Val Ala Lys Thr Leu Gln Glu 
1               5           


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VL region

<400>  8

Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Ile Ser Ile Glu Cys Arg Thr Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Lys Thr Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Phe Cys Leu Gln Gly Phe Lys Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  9
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VL region

<400>  9
gacatcctga tgacacagtc tccagcttcc ctgtctgcat ctctgggaga aactatctcc       60

atcgaatgtc gaacaagtga agacatttac actaatttag cgtggtacca gcagaagtca      120

gggaaatctc ctcaactcct gatctatgtt gcaaagacgt tgcaagatgg ggtcccatca      180

cggttcagtg gcagtggatc tggcacgcat tattctctca agatcagcgg catgcaacct      240

gaagatgaag gggattattt ctgtctgcag ggtttcaagt ttccgtggac gttcggtgga      300

ggcaccaagc tggaactgaa a                                                321


<210>  10
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VL region with signal sequence underlined and 
       italicised

<400>  10

Met Asn Val Pro Thr Gln Phe Leu Gly Leu Leu Leu Leu Trp Ile Thr 
1               5                   10                  15      


Asp Gly Ile Cys Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Thr Ile Ser Ile Glu Cys Arg Thr Ser Glu Asp 
        35                  40                  45              


Ile Tyr Thr Asn Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Val Ala Lys Thr Leu Gln Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Ser Leu Lys Ile Ser 
                85                  90                  95      


Gly Met Gln Pro Glu Asp Glu Gly Asp Tyr Phe Cys Leu Gln Gly Phe 
            100                 105                 110         


Lys Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  11
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VL region with signal sequence underlined and 
       italicised

<400>  11
atgaatgtgc ccactcaatt ccttgggttg ttgctgctgt ggataacaga tggcatatgc       60

gacatcctga tgacacagtc tccagcttcc ctgtctgcat ctctgggaga aactatctcc      120

atcgaatgtc gaacaagtga agacatttac actaatttag cgtggtacca gcagaagtca      180

gggaaatctc ctcaactcct gatctatgtt gcaaagacgt tgcaagatgg ggtcccatca      240

cggttcagtg gcagtggatc tggcacgcat tattctctca agatcagcgg catgcaacct      300

gaagatgaag gggattattt ctgtctgcag ggtttcaagt ttccgtggac gttcggtgga      360

ggcaccaagc tggaactgaa a                                                381


<210>  12
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VH region

<400>  12

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      


Cys Val Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Met Val Thr Val Ser 
        115                 120         


<210>  13
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VH region

<400>  13
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgcactt tctctgggtt ttcactgagt acttatggtg tgggtgtggg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcaaacattt ggtgggatga tgataagcgc      180

tacaatccat ctctggaaaa ccgactcact atctccaagg acacctccaa caaccaagca      240

ttcctcaaga tcaccaatgt ggacactgca gatagcgcca catacttctg tgttcggacc      300

ccggcttact atggcagcca tccccctttt gactactggg gccaaggagt catggtcaca      360

gtctcg                                                                 366


<210>  14
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VH region with signal sequence underlined and 
       italicised

<400>  14

Met Asp Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Tyr Gly Val Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Glu Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn 
                85                  90                  95      


Asn Gln Ala Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Ser Ala 
            100                 105                 110         


Thr Tyr Phe Cys Val Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser 
    130                 135                 140     


<210>  15
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat Ab 1638 VH region with signal sequence underlined and 
       italicised

<400>  15
atggacaggc taacttcctc attcctactg ctgattgtcc ctgcatatgt cctgtctcag       60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact      120

tgcactttct ctgggttttc actgagtact tatggtgtgg gtgtgggctg gattcgtcag      180

ccttcaggga agggtctgga gtggctggca aacatttggt gggatgatga taagcgctac      240

aatccatctc tggaaaaccg actcactatc tccaaggaca cctccaacaa ccaagcattc      300

ctcaagatca ccaatgtgga cactgcagat agcgccacat acttctgtgt tcggaccccg      360

gcttactatg gcagccatcc cccttttgac tactggggcc aaggagtcat ggtcacagtc      420

tcg                                                                    423


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL7 V-region

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Lys Thr Leu Gln Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly Phe Lys Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL7 V-region

<400>  17
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gcactagcga ggacatctac accaacctgg cgtggtatca gcagaaacca      120

ggcaaagtgc cgaaactgct gatctacgtc gcgaaaaccc tccaggaagg tgtaccgtct      180

cgcttttccg gctctggtag cggtactcac tacaccctga ccatctcttc cctccagccg      240

gaagatgttg ctacctacta ttgcctccag ggcttcaaat tcccgtggac tttcggtggc      300

ggcacgaaag tggaaatcaa a                                                321


<210>  18
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL7 V-region (E. coli expression)

<400>  18

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu 
        35                  40                  45              


Asp Ile Tyr Thr Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Val Ala Lys Thr Leu Gln Glu Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly 
            100                 105                 110         


Phe Lys Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  19
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL7 V-region (E. coli expression)

<400>  19
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtcgcactag cgaggacatc tacaccaacc tggcgtggta tcagcagaaa      180

ccaggcaaag tgccgaaact gctgatctac gtcgcgaaaa ccctccagga aggtgtaccg      240

tctcgctttt ccggctctgg tagcggtact cactacaccc tgaccatctc ttccctccag      300

ccggaagatg ttgctaccta ctattgcctc cagggcttca aattcccgtg gactttcggt      360

ggcggcacga aagtggaaat caaa                                             384


<210>  20
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL7 light chain (V + constant)

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Lys Thr Leu Gln Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly Phe Lys Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL7 light chain (V + constant, E. coli expression)

<400>  21
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gcactagcga ggacatctac accaacctgg cgtggtatca gcagaaacca      120

ggcaaagtgc cgaaactgct gatctacgtc gcgaaaaccc tccaggaagg tgtaccgtct      180

cgcttttccg gctctggtag cggtactcac tacaccctga ccatctcttc cctccagccg      240

gaagatgttg ctacctacta ttgcctccag ggcttcaaat tcccgtggac tttcggtggc      300

ggcacgaaag tggaaatcaa acgtacggta gcggccccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcac cagtaacaaa aagttttaat agaggggagt gt                         642


<210>  22
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL7 light chain (V + constant, mammalian expression)

<400>  22
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gcactagcga ggacatctac accaacctgg cgtggtatca gcagaaacca      120

ggcaaagtgc cgaaactgct gatctacgtc gcgaaaaccc tccaggaagg tgtaccgtct      180

cgcttttccg gctctggtag cggtactcac tacaccctga ccatctcttc cctccagccg      240

gaagatgttg ctacctacta ttgcctccag ggcttcaaat tcccgtggac tttcggtggc      300

ggcacgaaag tggaaatcaa acggaccgtg gccgctccct ccgtgttcat cttcccaccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtca ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gtccttcaac cggggcgagt gc                         642


<210>  23
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL7 light chain (E. coli expression)

<400>  23

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu 
        35                  40                  45              


Asp Ile Tyr Thr Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Val Ala Lys Thr Leu Gln Glu Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly 
            100                 105                 110         


Phe Lys Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  24
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL7 light chain (E. coli expression)

<400>  24
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtcgcactag cgaggacatc tacaccaacc tggcgtggta tcagcagaaa      180

ccaggcaaag tgccgaaact gctgatctac gtcgcgaaaa ccctccagga aggtgtaccg      240

tctcgctttt ccggctctgg tagcggtact cactacaccc tgaccatctc ttccctccag      300

ccggaagatg ttgctaccta ctattgcctc cagggcttca aattcccgtg gactttcggt      360

ggcggcacga aagtggaaat caaacgtacg gtagcggccc catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct caccagtaac aaaaagtttt aatagagggg agtgt                      705


<210>  25
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 V-region

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120         


<210>  26
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 V-region

<400>  26
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag cgtccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagccgtg ataacgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgcgcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac aatggttacc      360

gtctcg                                                                 366


<210>  27
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 V-region (E. coli expression)

<400>  27

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Tyr Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His 
        115                 120                 125             


Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140             


<210>  28
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 V-region (E.coli expression)

<400>  28
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc agctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cagcgtccgg cttctctctg tctacctacg gcgttggtgt tggttgggta      180

cgtcaggctc caggtaaagg tctggaatgg ctcgcaaaca tctggtggga cgacgataaa      240

cgctacaacc cgtccctgga gaaccgcttc accattagcc gtgataacgc gaaaaactcc      300

gcgtatctcc agatgaactc cctgcgtgcc gaagacacgg ctgtgtacta ttgcgcgcgc      360

actccggcgt actatggctc tcacccaccg tttgattact ggggtcaggg taccatggtt      420

accgtctcg                                                              429


<210>  29
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab heavy chain (V + human gamma-1 CH1)

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys 
225     


<210>  30
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab heavy chain (V + human gamma-1 CH1)

<400>  30
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag cgtccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagccgtg ataacgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgcgcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac catggttacc      360

gtctcgagcg cttctacaaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt cgacaagaaa      660

gttgagccca aatcttgt                                                    678


<210>  31
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab heavy chain with (E. coli expression)

<400>  31

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Tyr Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His 
        115                 120                 125             


Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys 
                245         


<210>  32
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab heavy chain (E. coli expression)

<400>  32
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc agctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cagcgtccgg cttctctctg tctacctacg gcgttggtgt tggttgggta      180

cgtcaggctc caggtaaagg tctggaatgg ctcgcaaaca tctggtggga cgacgataaa      240

cgctacaacc cgtccctgga gaaccgcttc accattagcc gtgataacgc gaaaaactcc      300

gcgtatctcc agatgaactc cctgcgtgcc gaagacacgg ctgtgtacta ttgcgcgcgc      360

actccggcgt actatggctc tcacccaccg tttgattact ggggtcaggg taccatggtt      420

accgtctcga gcgcttctac aaagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtcgacaag      720

aaagttgagc ccaaatcttg t                                                741


<210>  33
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab' heavy chain (V + human gamma-1 CH1 + hinge)

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Ala Ala 
225                 230                 


<210>  34
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab' heavy chain (V + human gamma-1 CH1 + hinge)

<400>  34
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag cgtccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagccgtg ataacgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgcgcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac catggttacc      360

gtctcgagcg cttctacaaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt cgacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcgccg cg                         702


<210>  35
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab' heavy chain (E. coli expression)

<400>  35

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Tyr Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His 
        115                 120                 125             


Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Ala Ala 
                245                 250                 255 


<210>  36
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 Fab' heavy chain (E. coli expression)

<400>  36
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc agctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cagcgtccgg cttctctctg tctacctacg gcgttggtgt tggttgggta      180

cgtcaggctc caggtaaagg tctggaatgg ctcgcaaaca tctggtggga cgacgataaa      240

cgctacaacc cgtccctgga gaaccgcttc accattagcc gtgataacgc gaaaaactcc      300

gcgtatctcc agatgaactc cctgcgtgcc gaagacacgg ctgtgtacta ttgcgcgcgc      360

actccggcgt actatggctc tcacccaccg tttgattact ggggtcaggg taccatggtt      420

accgtctcga gcgcttctac aaagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtcgacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcg ccgcg                      765


<210>  37
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 IgG4 heavy chain (V + human gamma-4P constant)

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  38
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 IgG4 heavy chain (V + human gamma-4P constant)

<400>  38
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag cgtccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagccgtg ataacgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgcgcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac aatggttacc      360

gtctcgtctg cctccaccaa gggcccctcc gtgttccctc tggccccttg ctcccggtcc      420

acctccgagt ctaccgccgc tctgggctgc ctggtcaagg actacttccc cgagcccgtg      480

acagtgtcct ggaactctgg cgccctgacc tccggcgtgc acaccttccc tgccgtgctg      540

cagtcctccg gcctgtactc cctgtcctcc gtcgtgaccg tgccctcctc cagcctgggc      600

accaagacct acacctgtaa cgtggaccac aagccctcca acaccaaggt ggacaagcgg      660

gtggaatcta agtacggccc tccctgcccc ccctgccctg cccctgaatt tctgggcgga      720

ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatctc ccggaccccc      780

gaagtgacct gcgtggtggt ggacgtgtcc caggaagatc ccgaggtcca gttcaattgg      840

tacgtggacg gcgtggaagt gcacaatgcc aagaccaagc ccagagagga acagttcaac      900

tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaaa      960

gagtacaagt gcaaggtgtc caacaagggc ctgccctcca gcatcgaaaa gaccatctcc     1020

aaggccaagg gccagccccg cgagccccag gtgtacaccc tgccccctag ccaggaagag     1080

atgaccaaga accaggtgtc cctgacctgt ctggtcaagg gcttctaccc ctccgacatt     1140

gccgtggaat gggagtccaa cggccagccc gagaacaact acaagaccac cccccctgtg     1200

ctggacagcg acggctcctt cttcctgtac tctcggctga ccgtggacaa gtcccggtgg     1260

caggaaggca acgtcttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagtccc tgtccctgag cctgggcaag                                      1350


<210>  39
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 IgG4 heavy chain (V + human gamma-4P constant 
       mammalian, no c-terminal lys)

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


<210>  40
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL7 FabFv light chain

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Lys Thr Leu Gln Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly Phe Lys Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
225                 230                 235                 240 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro 
                245                 250                 255     


Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 
            260                 265                 270         


Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val 
        275                 280                 285             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    290                 295                 300                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly 
305                 310                 315                 320 


Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val 
                325                 330                 335     


Glu Ile Lys Arg Thr 
            340     


<210>  41
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL7 FabFv light chain

<400>  41
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gcactagcga ggacatctac accaacctgg cgtggtatca gcagaaacca      120

ggcaaagtgc cgaaactgct gatctacgtc gcgaaaaccc tccaggaagg tgtaccgtct      180

cgcttttccg gctctggtag cggtactcac tacaccctga ccatctcttc cctccagccg      240

gaagatgttg ctacctacta ttgcctccag ggcttcaaat tcccgtggac tttcggtggc      300

ggcacgaaag tggaaatcaa acgtacggta gcggccccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gtggtggagg tggctctggc      660

ggtggtggct ccggaggcgg aggaagcgac atccagatga cccagagccc ttcctctgta      720

agcgccagtg tcggagacag agtgactatt acctgccaaa gctccccttc agtctggtcc      780

aattttctat cctggtatca gcaaaagccc ggaaaggctc ctaaattgct gatctacgaa      840

gcaagcaaac tcaccagcgg cgtgcccagc aggttcagcg gcagtgggtc tggaactgac      900

tttaccctga caatctcctc actccagccc gaggacttcg ccacctatta ctgcggtgga      960

ggttacagta gcataagtga tacgacattt ggatgcggca ctaaagtgga aatcaagcgt     1020

acc                                                                   1023


<210>  42
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH33 FabFv heavy chain

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser 
            260                 265                 270         


Asn Tyr Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 
        275                 280                 285             


Trp Ile Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp 
    290                 295                 300                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu 
            340                 345                 350         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360             


<210>  43
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH33 FabFv heavy chain

<400>  43
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag cgtccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagccgtg ataacgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgcgcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac aatggttacc      360

gtctcgtccg cttctacaaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctctg gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgttc cggaggtggc ggttccggag gtggcggtac aggtggcggt      720

gggtccgaag tccagctgct tgaatccgga ggcggactcg tgcagcccgg aggcagtctt      780

cgcttgtcct gcgctgtatc tggaatcgac ctgagcaatt acgccatcaa ctgggtgaga      840

caggcacctg ggaaatgcct cgaatggatc ggcattatat gggctagtgg gacgaccttt      900

tatgctacat gggcgaaggg tagattcaca atctcacggg ataatagtaa gaacacagtg      960

tacctgcaga tgaactccct gcgagcagag gataccgccg tttactattg tgctcgcact     1020

gtcccaggtt atagcactgc accctacttt gatctgtggg ggcagggcac tctggtcacc     1080

gtctcgtcc                                                             1089


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGKV1-27 JK4 acceptor framework

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGKV1-27 JK4 acceptor framework

<400>  45
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg cccctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  46
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGHV3-7 JH3 acceptor framework

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  47
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGHV3-7 JH3 acceptor framework

<400>  47
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatgct      300

tttgatgtct ggggccaagg gacaatggtc accgtctctt ca                         342


<210>  48
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FcRn alpha chain extracellular sequence

<400>  48

Ala Glu Ser His Leu Ser Leu Leu Tyr His Leu Thr Ala Val Ser Ser 
1               5                   10                  15      


Pro Ala Pro Gly Thr Pro Ala Phe Trp Val Ser Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Ser Tyr Asn Ser Leu Arg Gly Glu Ala Glu Pro Cys 
        35                  40                  45              


Gly Ala Trp Val Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Arg Ile Lys Glu Lys Leu Phe Leu Glu Ala Phe Lys 
65                  70                  75                  80  


Ala Leu Gly Gly Lys Gly Pro Tyr Thr Leu Gln Gly Leu Leu Gly Cys 
                85                  90                  95      


Glu Leu Gly Pro Asp Asn Thr Ser Val Pro Thr Ala Lys Phe Ala Leu 
            100                 105                 110         


Asn Gly Glu Glu Phe Met Asn Phe Asp Leu Lys Gln Gly Thr Trp Gly 
        115                 120                 125             


Gly Asp Trp Pro Glu Ala Leu Ala Ile Ser Gln Arg Trp Gln Gln Gln 
    130                 135                 140                 


Asp Lys Ala Ala Asn Lys Glu Leu Thr Phe Leu Leu Phe Ser Cys Pro 
145                 150                 155                 160 


His Arg Leu Arg Glu His Leu Glu Arg Gly Arg Gly Asn Leu Glu Trp 
                165                 170                 175     


Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Ser Ser Pro Gly 
            180                 185                 190         


Phe Ser Val Leu Thr Cys Ser Ala Phe Ser Phe Tyr Pro Pro Glu Leu 
        195                 200                 205             


Gln Leu Arg Phe Leu Arg Asn Gly Leu Ala Ala Gly Thr Gly Gln Gly 
    210                 215                 220                 


Asp Phe Gly Pro Asn Ser Asp Gly Ser Phe His Ala Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Val Lys Ser Gly Asp Glu His His Tyr Cys Cys Ile Val Gln His 
                245                 250                 255     


Ala Gly Leu Ala Gln Pro Leu Arg Val Glu Leu Glu Ser Pro Ala Lys 
            260                 265                 270         


Ser Ser 
        


<210>  49
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat ?2M

<400>  49

Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu 
1               5                   10                  15      


Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser Gln Phe His Pro 
            20                  25                  30          


Pro Gln Ile Glu Ile Glu Leu Leu Lys Asn Gly Lys Lys Ile Pro Asn 
        35                  40                  45              


Ile Glu Met Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile 
    50                  55                  60                  


Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp Val Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Lys His Val Thr Leu Lys Glu Pro Lys Thr Val Thr Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  50
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ?2M including signal sequence

<400>  50

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638gL2 V-region

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Lys Thr Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly Phe Lys Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638gL2 V-region

<400>  52
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gcactagcga ggacatctac accaacctgg cgtggtatca gcagaaacca      120

ggcaaagtgc cgaaactgct gatctacgtc gcgaaaaccc tccaggacgg tgtaccgtct      180

cgcttttccg gctctggtag cggtactcac tacaccctga ccatctcttc cctccagccg      240

gaagatgttg ctacctacta ttgcctccag ggcttcaaat tcccgtggac tttcggtggc      300

ggcacgaaag tggaaatcaa a                                                321


<210>  53
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL2 V-region (E. coli expression)

<400>  53

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu 
        35                  40                  45              


Asp Ile Tyr Thr Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Val Ala Lys Thr Leu Gln Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly 
            100                 105                 110         


Phe Lys Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  54
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL2 V-region (E. coli expression)

<400>  54
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtcgcactag cgaggacatc tacaccaacc tggcgtggta tcagcagaaa      180

ccaggcaaag tgccgaaact gctgatctac gtcgcgaaaa ccctccagga cggtgtaccg      240

tctcgctttt ccggctctgg tagcggtact cactacaccc tgaccatctc ttccctccag      300

ccggaagatg ttgctaccta ctattgcctc cagggcttca aattcccgtg gactttcggt      360

ggcggcacga aagtggaaat caaa                                             384


<210>  55
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL2 light chain (V + constant)

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Lys Thr Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly Phe Lys Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  56
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL2 light chain (V + constant, codon optimized for E. coli 
       expression)

<400>  56
gatatccaga tgacccagag tccaagcagt ctctccgcca gcgtaggcga tcgtgtgact       60

attacctgtc gcactagcga ggacatctac accaacctgg cgtggtatca gcagaaacca      120

ggcaaagtgc cgaaactgct gatctacgtc gcgaaaaccc tccaggacgg tgtaccgtct      180

cgcttttccg gctctggtag cggtactcac tacaccctga ccatctcttc cctccagccg      240

gaagatgttg ctacctacta ttgcctccag ggcttcaaat tcccgtggac tttcggtggc      300

ggcacgaaag tggaaatcaa acgtacggta gcggccccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcac cagtaacaaa aagttttaat agaggggagt gt                         642


<210>  57
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gL2 light chain (E. coli expression)

<400>  57

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu 
        35                  40                  45              


Asp Ile Tyr Thr Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Val Ala Lys Thr Leu Gln Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Gly 
            100                 105                 110         


Phe Lys Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  58
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gL2 light chain (E. coli expression)

<400>  58
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctgatatcc agatgaccca gagtccaagc agtctctccg ccagcgtagg cgatcgtgtg      120

actattacct gtcgcactag cgaggacatc tacaccaacc tggcgtggta tcagcagaaa      180

ccaggcaaag tgccgaaact gctgatctac gtcgcgaaaa ccctccagga cggtgtaccg      240

tctcgctttt ccggctctgg tagcggtact cactacaccc tgaccatctc ttccctccag      300

ccggaagatg ttgctaccta ctattgcctc cagggcttca aattcccgtg gactttcggt      360

ggcggcacga aagtggaaat caaacgtacg gtagcggccc catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct caccagtaac aaaaagtttt aatagagggg agtgt                      705


<210>  59
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638gH2 V-region

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Lys Asp Thr Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120         


<210>  60
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638gH2 V-region

<400>  60
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcat tctccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagcaaag ataccgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgttcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac catggttacc      360

gtctcg                                                                 366


<210>  61
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH2 V-region with signal sequence underlined and italicized 
       (E. coli expression)

<400>  61

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Tyr Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Glu Asn Arg Phe Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ala Lys Asn Ser Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Thr Pro Ala Tyr Tyr Gly Ser His 
        115                 120                 125             


Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser 
    130                 135                 140             


<210>  62
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH2 V-region with signal sequence underlined and italicized 
       (E. coli expression)

<400>  62
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc agctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cattctccgg cttctctctg tctacctacg gcgttggtgt tggttgggta      180

cgtcaggctc caggtaaagg tctggaatgg ctcgcaaaca tctggtggga cgacgataaa      240

cgctacaacc cgtccctgga gaaccgcttc accattagca aagataccgc gaaaaactcc      300

gcgtatctcc agatgaactc cctgcgtgcc gaagacacgg ctgtgtacta ttgcgttcgc      360

actccggcgt actatggctc tcacccaccg tttgattact ggggtcaggg taccatggtt      420

accgtctcg                                                              429


<210>  63
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH2 Fab' heavy chain (V + human gamma-1 CH1 + hinge)

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Lys Asp Thr Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Ala Ala 
225                 230                 


<210>  64
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH2 Fab' heavy chain (V + human gamma-1 CH1 + hinge)

<400>  64
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcat tctccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagcaaag ataccgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgttcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac catggttacc      360

gtctcgagcg cttctacaaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt cgacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcgccg cg                         702


<210>  65
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638 gH2 Fab' heavy chain (E. coli expression)

<400>  65

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Phe Ser Gly Phe 
        35                  40                  45              


Ser Leu Ser Thr Tyr Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys 
65                  70                  75                  80  


Arg Tyr Asn Pro Ser Leu Glu Asn Arg Phe Thr Ile Ser Lys Asp Thr 
                85                  90                  95      


Ala Lys Asn Ser Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Val Arg Thr Pro Ala Tyr Tyr Gly Ser His 
        115                 120                 125             


Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Ala Ala 
                245                 250                 255 


<210>  66
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638 gH2 Fab' heavy chain d (E. coli expression)

<400>  66
atgaagaaga ctgctatagc aattgcagtg gcgctagctg gtttcgccac cgtggcgcaa       60

gctgaggttc agctggtcga gtctggaggc gggcttgtcc agcctggagg gagcctgcgt      120

ctctcttgtg cattctccgg cttctctctg tctacctacg gcgttggtgt tggttgggta      180

cgtcaggctc caggtaaagg tctggaatgg ctcgcaaaca tctggtggga cgacgataaa      240

cgctacaacc cgtccctgga gaaccgcttc accattagca aagataccgc gaaaaactcc      300

gcgtatctcc agatgaactc cctgcgtgcc gaagacacgg ctgtgtacta ttgcgttcgc      360

actccggcgt actatggctc tcacccaccg tttgattact ggggtcaggg taccatggtt      420

accgtctcga gcgcttctac aaagggccca tcggtcttcc ccctggcacc ctcctccaag      480

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      660

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtcgacaag      720

aaagttgagc ccaaatcttg tgacaaaact cacacatgcg ccgcg                      765


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-termial sequence Heavy chain

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal sequence Light chain

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human JH3

<400>  69

Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser 
1               5                   10                  15  


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of CDR-H3

<400>  70

Asp Ala Phe Asp Val 
1               5   


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JK4 sequence

<400>  71

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  72
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ?2-microglobulin

<400>  72

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  73
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1638gH33 IgG1 heavy chain (V + human gamma-1 constant)

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Glu Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Pro Ala Tyr Tyr Gly Ser His Pro Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  74
<211>  1965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1638gH33 IgG1 heavy chain (V + human gamma-1 constant, exons 
       underlined)

<400>  74
gaggttcagc tggtcgagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag cgtccggctt ctctctgtct acctacggcg ttggtgttgg ttgggtacgt      120

caggctccag gtaaaggtct ggaatggctc gcaaacatct ggtgggacga cgataaacgc      180

tacaacccgt ccctggagaa ccgcttcacc attagccgtg ataacgcgaa aaactccgcg      240

tatctccaga tgaactccct gcgtgccgaa gacacggctg tgtactattg cgcgcgcact      300

ccggcgtact atggctctca cccaccgttt gattactggg gtcagggtac aatggttacc      360

gtctcgagcg cttctacaaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt cgacaagaaa      660

gttggtgaga ggccagcaca gggagggagg gtgtctgctg gaagccaggc tcagcgctcc      720

tgcctggacg catcccggct atgcagcccc agtccagggc agcaaggcag gccccgtctg      780

cctcttcacc cggaggcctc tgcccgcccc actcatgctc agggagaggg tcttctggct      840

ttttccccag gctctgggca ggcacaggct aggtgcccct aacccaggcc ctgcacacaa      900

aggggcaggt gctgggctca gacctgccaa gagccatatc cgggaggacc ctgcccctga      960

cctaagccca ccccaaaggc caaactctcc actccctcag ctcggacacc ttctctcctc     1020

ccagatctga gtaactccca atcttctctc tgcagagccc aaatcttgtg acaaaactca     1080

cacatgccca ccgtgcccag gtaagccagc ccaggcctcg ccctccagct caaggcggga     1140

caggtgccct agagtagcct gcatccaggg acaggcccca gccgggtgct gacacgtcca     1200

cctccatctc ttcctcagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc     1260

caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg     1320

acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc     1380

ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg     1440

tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca     1500

acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggt gggacccgtg     1560

gggtgcgagg gccacatgga cagaggccgg ctcggcccac cctctgccct gagagtgacc     1620

gctgtaccaa cctctgtccc tacagggcag ccccgagaac cacaggtgta caccctgccc     1680

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1740

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1800

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1860

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1920

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1965


