                         SEQUENCE LISTING

<110>  New England Biolabs, Inc.
 
<120>  DNMT Inhibitors

<130>  NEB-373-PCT

<150>  61/903,004
<151>  2013-11-12

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
ccgggacgca ggcggcguca ggc                                               23


<210>  2
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
ccgggaagca ggcggcguca ggc                                               23


<210>  3
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
gccaguggcg aggggcggcg cgg                                               23


<210>  4
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
gacaguggag aggggcggag cgg                                               23


<210>  5
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
uuaaugcuaa ucgugauagg ggu                                               23


<210>  6
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
uuaaugcuaa ucgugauagg ggu                                               23


<210>  7
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
uuaaugcuaa ucgugauagg ggu                                               23


<210>  8
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
uuaaugcuaa ucgugauagg ggu                                               23


<210>  9
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
uuaaugcuaa ucgugauagg ggu                                               23


<210>  10
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
uuaaugcuaa ucgugauagg ggu                                               23


<210>  11
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
uuaaugcuaa ucgugauagg ggu                                               23


<210>  12
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
uuaaugcuaa ucgugauagg ggu                                               23


<210>  13
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
uuaaugcuaa ucgugauagg ggu                                               23


<210>  14
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
uuaaugcuaa ucgugauagg ggu                                               23


<210>  15
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
uuaaugcuaa ucgugauagg ggu                                               23


<210>  16
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
uuaaugcuaa ucgugauagg ggu                                               23


<210>  17
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
uuaaugcuaa ucgugauagg ggu                                               23


<210>  18
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
uuaaugcuaa ucgugauagg ggu                                               23


<210>  19
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
uuaggguuag gg                                                           12


<210>  20
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20
augggguggg gu                                                           12


<210>  21
<211>  1616
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Ala Arg Thr Ala Pro Ala Arg Val Pro Thr Leu Ala Val Pro 
1               5                   10                  15      


Ala Ile Ser Leu Pro Asp Asp Val Arg Arg Arg Leu Lys Asp Leu Glu 
            20                  25                  30          


Arg Asp Ser Leu Thr Glu Lys Glu Cys Val Lys Glu Lys Leu Asn Leu 
        35                  40                  45              


Leu His Glu Phe Leu Gln Thr Glu Ile Lys Asn Gln Leu Cys Asp Leu 
    50                  55                  60                  


Glu Thr Lys Leu Arg Lys Glu Glu Leu Ser Glu Glu Gly Tyr Leu Ala 
65                  70                  75                  80  


Lys Val Lys Ser Leu Leu Asn Lys Asp Leu Ser Leu Glu Asn Gly Ala 
                85                  90                  95      


His Ala Tyr Asn Arg Glu Val Asn Gly Arg Leu Glu Asn Gly Asn Gln 
            100                 105                 110         


Ala Arg Ser Glu Ala Arg Arg Val Gly Met Ala Asp Ala Asn Ser Pro 
        115                 120                 125             


Pro Lys Pro Leu Ser Lys Pro Arg Thr Pro Arg Arg Ser Lys Ser Asp 
    130                 135                 140                 


Gly Glu Ala Lys Pro Glu Pro Ser Pro Ser Pro Arg Ile Thr Arg Lys 
145                 150                 155                 160 


Ser Thr Arg Gln Thr Thr Ile Thr Ser His Phe Ala Lys Gly Pro Ala 
                165                 170                 175     


Lys Arg Lys Pro Gln Glu Glu Ser Glu Arg Ala Lys Ser Asp Glu Ser 
            180                 185                 190         


Ile Lys Glu Glu Asp Lys Asp Gln Asp Glu Lys Arg Arg Arg Val Thr 
        195                 200                 205             


Ser Arg Glu Arg Val Ala Arg Pro Leu Pro Ala Glu Glu Pro Glu Arg 
    210                 215                 220                 


Ala Lys Ser Gly Thr Arg Thr Glu Lys Glu Glu Glu Arg Asp Glu Lys 
225                 230                 235                 240 


Glu Glu Lys Arg Leu Arg Ser Gln Thr Lys Glu Pro Thr Pro Lys Gln 
                245                 250                 255     


Lys Leu Lys Glu Glu Pro Asp Arg Glu Ala Arg Ala Gly Val Gln Ala 
            260                 265                 270         


Asp Glu Asp Glu Asp Gly Asp Glu Lys Asp Glu Lys Lys His Arg Ser 
        275                 280                 285             


Gln Pro Lys Asp Leu Ala Ala Lys Arg Arg Pro Glu Glu Lys Glu Pro 
    290                 295                 300                 


Glu Lys Val Asn Pro Gln Ile Ser Asp Glu Lys Asp Glu Asp Glu Lys 
305                 310                 315                 320 


Glu Glu Lys Arg Arg Lys Thr Thr Pro Lys Glu Pro Thr Glu Lys Lys 
                325                 330                 335     


Met Ala Arg Ala Lys Thr Val Met Asn Ser Lys Thr His Pro Pro Lys 
            340                 345                 350         


Cys Ile Gln Cys Gly Gln Tyr Leu Asp Asp Pro Asp Leu Lys Tyr Gly 
        355                 360                 365             


Gln His Pro Pro Asp Ala Val Asp Glu Pro Gln Met Leu Thr Asn Glu 
    370                 375                 380                 


Lys Leu Ser Ile Phe Asp Ala Asn Glu Ser Gly Phe Glu Ser Tyr Glu 
385                 390                 395                 400 


Ala Leu Pro Gln His Lys Leu Thr Cys Phe Ser Val Tyr Cys Lys His 
                405                 410                 415     


Gly His Leu Cys Pro Ile Asp Thr Gly Leu Ile Glu Lys Asn Ile Glu 
            420                 425                 430         


Leu Phe Phe Ser Gly Ser Ala Lys Pro Ile Tyr Asp Asp Asp Pro Ser 
        435                 440                 445             


Leu Glu Gly Gly Val Asn Gly Lys Asn Leu Gly Pro Ile Asn Glu Trp 
    450                 455                 460                 


Trp Ile Thr Gly Phe Asp Gly Gly Glu Lys Ala Leu Ile Gly Phe Ser 
465                 470                 475                 480 


Thr Ser Phe Ala Glu Tyr Ile Leu Met Asp Pro Ser Pro Glu Tyr Ala 
                485                 490                 495     


Pro Ile Phe Gly Leu Met Gln Glu Lys Ile Tyr Ile Ser Lys Ile Val 
            500                 505                 510         


Val Glu Phe Leu Gln Ser Asn Ser Asp Ser Thr Tyr Glu Asp Leu Ile 
        515                 520                 525             


Asn Lys Ile Glu Thr Thr Val Pro Pro Ser Gly Leu Asn Leu Asn Arg 
    530                 535                 540                 


Phe Thr Glu Asp Ser Leu Leu Arg His Ala Gln Phe Val Val Glu Gln 
545                 550                 555                 560 


Val Glu Ser Tyr Asp Glu Ala Gly Asp Ser Asp Glu Gln Pro Ile Phe 
                565                 570                 575     


Leu Thr Pro Cys Met Arg Asp Leu Ile Lys Leu Ala Gly Val Thr Leu 
            580                 585                 590         


Gly Gln Arg Arg Ala Gln Ala Arg Arg Gln Thr Ile Arg His Ser Thr 
        595                 600                 605             


Arg Glu Lys Asp Arg Gly Pro Thr Lys Ala Thr Thr Thr Lys Leu Val 
    610                 615                 620                 


Tyr Gln Ile Phe Asp Thr Phe Phe Ala Glu Gln Ile Glu Lys Asp Asp 
625                 630                 635                 640 


Arg Glu Asp Lys Glu Asn Ala Phe Lys Arg Arg Arg Cys Gly Val Cys 
                645                 650                 655     


Glu Val Cys Gln Gln Pro Glu Cys Gly Lys Cys Lys Ala Cys Lys Asp 
            660                 665                 670         


Met Val Lys Phe Gly Gly Ser Gly Arg Ser Lys Gln Ala Cys Gln Glu 
        675                 680                 685             


Arg Arg Cys Pro Asn Met Ala Met Lys Glu Ala Asp Asp Asp Glu Glu 
    690                 695                 700                 


Val Asp Asp Asn Ile Pro Glu Met Pro Ser Pro Lys Lys Met His Gln 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Gln Asn Lys Asn Arg Ile Ser Trp Val Gly Glu 
                725                 730                 735     


Ala Val Lys Thr Asp Gly Lys Lys Ser Tyr Tyr Lys Lys Val Cys Ile 
            740                 745                 750         


Asp Ala Glu Thr Leu Glu Val Gly Asp Cys Val Ser Val Ile Pro Asp 
        755                 760                 765             


Asp Ser Ser Lys Pro Leu Tyr Leu Ala Arg Val Thr Ala Leu Trp Glu 
    770                 775                 780                 


Asp Ser Ser Asn Gly Gln Met Phe His Ala His Trp Phe Cys Ala Gly 
785                 790                 795                 800 


Thr Asp Thr Val Leu Gly Ala Thr Ser Asp Pro Leu Glu Leu Phe Leu 
                805                 810                 815     


Val Asp Glu Cys Glu Asp Met Gln Leu Ser Tyr Ile His Ser Lys Val 
            820                 825                 830         


Lys Val Ile Tyr Lys Ala Pro Ser Glu Asn Trp Ala Met Glu Gly Gly 
        835                 840                 845             


Met Asp Pro Glu Ser Leu Leu Glu Gly Asp Asp Gly Lys Thr Tyr Phe 
    850                 855                 860                 


Tyr Gln Leu Trp Tyr Asp Gln Asp Tyr Ala Arg Phe Glu Ser Pro Pro 
865                 870                 875                 880 


Lys Thr Gln Pro Thr Glu Asp Asn Lys Phe Lys Phe Cys Val Ser Cys 
                885                 890                 895     


Ala Arg Leu Ala Glu Met Arg Gln Lys Glu Ile Pro Arg Val Leu Glu 
            900                 905                 910         


Gln Leu Glu Asp Leu Asp Ser Arg Val Leu Tyr Tyr Ser Ala Thr Lys 
        915                 920                 925             


Asn Gly Ile Leu Tyr Arg Val Gly Asp Gly Val Tyr Leu Pro Pro Glu 
    930                 935                 940                 


Ala Phe Thr Phe Asn Ile Lys Leu Ser Ser Pro Val Lys Arg Pro Arg 
945                 950                 955                 960 


Lys Glu Pro Val Asp Glu Asp Leu Tyr Pro Glu His Tyr Arg Lys Tyr 
                965                 970                 975     


Ser Asp Tyr Ile Lys Gly Ser Asn Leu Asp Ala Pro Glu Pro Tyr Arg 
            980                 985                 990         


Ile Gly Arg Ile Lys Glu Ile Phe  Cys Pro Lys Lys Ser  Asn Gly Arg 
        995                 1000                 1005             


Pro Asn  Glu Thr Asp Ile Lys  Ile Arg Val Asn Lys  Phe Tyr Arg 
    1010                 1015                 1020             


Pro Glu  Asn Thr His Lys Ser  Thr Pro Ala Ser Tyr  His Ala Asp 
    1025                 1030                 1035             


Ile Asn  Leu Leu Tyr Trp Ser  Asp Glu Glu Ala Val  Val Asp Phe 
    1040                 1045                 1050             


Lys Ala  Val Gln Gly Arg Cys  Thr Val Glu Tyr Gly  Glu Asp Leu 
    1055                 1060                 1065             


Pro Glu  Cys Val Gln Val Tyr  Ser Met Gly Gly Pro  Asn Arg Phe 
    1070                 1075                 1080             


Tyr Phe  Leu Glu Ala Tyr Asn  Ala Lys Ser Lys Ser  Phe Glu Asp 
    1085                 1090                 1095             


Pro Pro  Asn His Ala Arg Ser  Pro Gly Asn Lys Gly  Lys Gly Lys 
    1100                 1105                 1110             


Gly Lys  Gly Lys Gly Lys Pro  Lys Ser Gln Ala Cys  Glu Pro Ser 
    1115                 1120                 1125             


Glu Pro  Glu Ile Glu Ile Lys  Leu Pro Lys Leu Arg  Thr Leu Asp 
    1130                 1135                 1140             


Val Phe  Ser Gly Cys Gly Gly  Leu Ser Glu Gly Phe  His Gln Ala 
    1145                 1150                 1155             


Gly Ile  Ser Asp Thr Leu Trp  Ala Ile Glu Met Trp  Asp Pro Ala 
    1160                 1165                 1170             


Ala Gln  Ala Phe Arg Leu Asn  Asn Pro Gly Ser Thr  Val Phe Thr 
    1175                 1180                 1185             


Glu Asp  Cys Asn Ile Leu Leu  Lys Leu Val Met Ala  Gly Glu Thr 
    1190                 1195                 1200             


Thr Asn  Ser Arg Gly Gln Arg  Leu Pro Gln Lys Gly  Asp Val Glu 
    1205                 1210                 1215             


Met Leu  Cys Gly Gly Pro Pro  Cys Gln Gly Phe Ser  Gly Met Asn 
    1220                 1225                 1230             


Arg Phe  Asn Ser Arg Thr Tyr  Ser Lys Phe Lys Asn  Ser Leu Val 
    1235                 1240                 1245             


Val Ser  Phe Leu Ser Tyr Cys  Asp Tyr Tyr Arg Pro  Arg Phe Phe 
    1250                 1255                 1260             


Leu Leu  Glu Asn Val Arg Asn  Phe Val Ser Phe Lys  Arg Ser Met 
    1265                 1270                 1275             


Val Leu  Lys Leu Thr Leu Arg  Cys Leu Val Arg Met  Gly Tyr Gln 
    1280                 1285                 1290             


Cys Thr  Phe Gly Val Leu Gln  Ala Gly Gln Tyr Gly  Val Ala Gln 
    1295                 1300                 1305             


Thr Arg  Arg Arg Ala Ile Ile  Leu Ala Ala Ala Pro  Gly Glu Lys 
    1310                 1315                 1320             


Leu Pro  Leu Phe Pro Glu Pro  Leu His Val Phe Ala  Pro Arg Ala 
    1325                 1330                 1335             


Cys Gln  Leu Ser Val Val Val  Asp Asp Lys Lys Phe  Val Ser Asn 
    1340                 1345                 1350             


Ile Thr  Arg Leu Ser Ser Gly  Pro Phe Arg Thr Ile  Thr Val Arg 
    1355                 1360                 1365             


Asp Thr  Met Ser Asp Leu Pro  Glu Val Arg Asn Gly  Ala Ser Ala 
    1370                 1375                 1380             


Leu Glu  Ile Ser Tyr Asn Gly  Glu Pro Gln Ser Trp  Phe Gln Arg 
    1385                 1390                 1395             


Gln Leu  Arg Gly Ala Gln Tyr  Gln Pro Ile Leu Arg  Asp His Ile 
    1400                 1405                 1410             


Cys Lys  Asp Met Ser Ala Leu  Val Ala Ala Arg Met  Arg His Ile 
    1415                 1420                 1425             


Pro Leu  Ala Pro Gly Ser Asp  Trp Arg Asp Leu Pro  Asn Ile Glu 
    1430                 1435                 1440             


Val Arg  Leu Ser Asp Gly Thr  Met Ala Arg Lys Leu  Arg Tyr Thr 
    1445                 1450                 1455             


His His  Asp Arg Lys Asn Gly  Arg Ser Ser Ser Gly  Ala Leu Arg 
    1460                 1465                 1470             


Gly Val  Cys Ser Cys Val Glu  Ala Gly Lys Ala Cys  Asp Pro Ala 
    1475                 1480                 1485             


Ala Arg  Gln Phe Asn Thr Leu  Ile Pro Trp Cys Leu  Pro His Thr 
    1490                 1495                 1500             


Gly Asn  Arg His Asn His Trp  Ala Gly Leu Tyr Gly  Arg Leu Glu 
    1505                 1510                 1515             


Trp Asp  Gly Phe Phe Ser Thr  Thr Val Thr Asn Pro  Glu Pro Met 
    1520                 1525                 1530             


Gly Lys  Gln Gly Arg Val Leu  His Pro Glu Gln His  Arg Val Val 
    1535                 1540                 1545             


Ser Val  Arg Glu Cys Ala Arg  Ser Gln Gly Phe Pro  Asp Thr Tyr 
    1550                 1555                 1560             


Arg Leu  Phe Gly Asn Ile Leu  Asp Lys His Arg Gln  Val Gly Asn 
    1565                 1570                 1575             


Ala Val  Pro Pro Pro Leu Ala  Lys Ala Ile Gly Leu  Glu Ile Lys 
    1580                 1585                 1590             


Leu Cys  Met Leu Ala Lys Ala  Arg Glu Ser Ala Ser  Ala Lys Ile 
    1595                 1600                 1605             


Lys Glu  Glu Glu Ala Ala Lys  Asp 
    1610                 1615     


<210>  22
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
ucuuugguua ucuagcugua uga                                               23


<210>  23
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
caaagugcuu acagugcagg uag                                               23


<210>  24
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
uagcuuauca gacugauguu ga                                                22


<210>  25
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
agguugggau cgguugcaau gcu                                               23


<210>  26
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
uauugcacuu gucccggccu gu                                                22


<210>  27
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
ucggauccgu cugagcuugg cu                                                22


<210>  28
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
auaaagcuag auaaccgaaa gu                                                22


<210>  29
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
uagcagcacg uaaauauugg cg                                                22


<210>  30
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
ugugcaaauc caugcaaaac uga                                               23


<210>  31
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
uaaagugcuu auagugcagg uag                                               23


<210>  32
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
guccaguuuu cccaggaauc ccu                                               23


<210>  33
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
ugagaacuga auuccauggg uu                                                22


<210>  34
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
acucaaaaug ggggcgcuuu cc                                                22


<210>  35
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35
aggacgugcg cggcggagag cgc                                               23


<210>  36
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
aguucgaugu cggggcucgg aau                                               23


<210>  37
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
aacgaguagg acgugcgcgg cgg                                               23


<210>  38
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
aaaagggaac gugagcuggg uuu                                               23


<210>  39
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
agcgaacaag uaccgugagg gaa                                               23


<210>  40
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N at position 1 may be A, C or U

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  N at position 2 may be A, G or U

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  N at position 3 may any nucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  N at position 4 may be A, G or U

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  N at position 5 may any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  N at position 6 may be A, G or U

<220>
<221>  misc_feature
<222>  (7)..(12)
<223>  N may be any nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  N at position 13 may be G, A or C

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  N may any nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  N at position 15 may be G or U

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  N may any nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  N at position 18 may be A, C or G

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  N at position 18 may be A or G

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  N may any nucleotide

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  N at position 22 may be A, G or U

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  N may be any nucleotide

<400>  40
nnnnnnnnnn nnnnnnnnng nnn                                               23


