                         SEQUENCE LISTING

<110>  INSTITUT DE CANCEROLOGIE DE L'OUEST
       UNIVERSITE D'ANGERS
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
 
<120>  METHOD FOR IN VITRO DIAGNOSING AND PROGNOSING OF TRIPLE NEGATIVE BREAST
       CANCER RECURRENCE

<130>  366562 D33045

<150>	EP 13306603.5

<151>	2013-11-22

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  2871
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Desmoplakin isoform 1

<400>  1

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Val  Arg Asn His Tyr Asn  Glu Glu Met 
    1190                 1195                 1200             


Ser Asn  Leu Arg Asn Lys Tyr  Glu Thr Glu Ile Asn  Ile Thr Lys 
    1205                 1210                 1215             


Thr Thr  Ile Lys Glu Ile Ser  Met Gln Lys Glu Asp  Asp Ser Lys 
    1220                 1225                 1230             


Asn Leu  Arg Asn Gln Leu Asp  Arg Leu Ser Arg Glu  Asn Arg Asp 
    1235                 1240                 1245             


Leu Lys  Asp Glu Ile Val Arg  Leu Asn Asp Ser Ile  Leu Gln Ala 
    1250                 1255                 1260             


Thr Glu  Gln Arg Arg Arg Ala  Glu Glu Asn Ala Leu  Gln Gln Lys 
    1265                 1270                 1275             


Ala Cys  Gly Ser Glu Ile Met  Gln Lys Lys Gln His  Leu Glu Ile 
    1280                 1285                 1290             


Glu Leu  Lys Gln Val Met Gln  Gln Arg Ser Glu Asp  Asn Ala Arg 
    1295                 1300                 1305             


His Lys  Gln Ser Leu Glu Glu  Ala Ala Lys Thr Ile  Gln Asp Lys 
    1310                 1315                 1320             


Asn Lys  Glu Ile Glu Arg Leu  Lys Ala Glu Phe Gln  Glu Glu Ala 
    1325                 1330                 1335             


Lys Arg  Arg Trp Glu Tyr Glu  Asn Glu Leu Ser Lys  Val Arg Asn 
    1340                 1345                 1350             


Asn Tyr  Asp Glu Glu Ile Ile  Ser Leu Lys Asn Gln  Phe Glu Thr 
    1355                 1360                 1365             


Glu Ile  Asn Ile Thr Lys Thr  Thr Ile His Gln Leu  Thr Met Gln 
    1370                 1375                 1380             


Lys Glu  Glu Asp Thr Ser Gly  Tyr Arg Ala Gln Ile  Asp Asn Leu 
    1385                 1390                 1395             


Thr Arg  Glu Asn Arg Ser Leu  Ser Glu Glu Ile Lys  Arg Leu Lys 
    1400                 1405                 1410             


Asn Thr  Leu Thr Gln Thr Thr  Glu Asn Leu Arg Arg  Val Glu Glu 
    1415                 1420                 1425             


Asp Ile  Gln Gln Gln Lys Ala  Thr Gly Ser Glu Val  Ser Gln Arg 
    1430                 1435                 1440             


Lys Gln  Gln Leu Glu Val Glu  Leu Arg Gln Val Thr  Gln Met Arg 
    1445                 1450                 1455             


Thr Glu  Glu Ser Val Arg Tyr  Lys Gln Ser Leu Asp  Asp Ala Ala 
    1460                 1465                 1470             


Lys Thr  Ile Gln Asp Lys Asn  Lys Glu Ile Glu Arg  Leu Lys Gln 
    1475                 1480                 1485             


Leu Ile  Asp Lys Glu Thr Asn  Asp Arg Lys Cys Leu  Glu Asp Glu 
    1490                 1495                 1500             


Asn Ala  Arg Leu Gln Arg Val  Gln Tyr Asp Leu Gln  Lys Ala Asn 
    1505                 1510                 1515             


Ser Ser  Ala Thr Glu Thr Ile  Asn Lys Leu Lys Val  Gln Glu Gln 
    1520                 1525                 1530             


Glu Leu  Thr Arg Leu Arg Ile  Asp Tyr Glu Arg Val  Ser Gln Glu 
    1535                 1540                 1545             


Arg Thr  Val Lys Asp Gln Asp  Ile Thr Arg Phe Gln  Asn Ser Leu 
    1550                 1555                 1560             


Lys Glu  Leu Gln Leu Gln Lys  Gln Lys Val Glu Glu  Glu Leu Asn 
    1565                 1570                 1575             


Arg Leu  Lys Arg Thr Ala Ser  Glu Asp Ser Cys Lys  Arg Lys Lys 
    1580                 1585                 1590             


Leu Glu  Glu Glu Leu Glu Gly  Met Arg Arg Ser Leu  Lys Glu Gln 
    1595                 1600                 1605             


Ala Ile  Lys Ile Thr Asn Leu  Thr Gln Gln Leu Glu  Gln Ala Ser 
    1610                 1615                 1620             


Ile Val  Lys Lys Arg Ser Glu  Asp Asp Leu Arg Gln  Gln Arg Asp 
    1625                 1630                 1635             


Val Leu  Asp Gly His Leu Arg  Glu Lys Gln Arg Thr  Gln Glu Glu 
    1640                 1645                 1650             


Leu Arg  Arg Leu Ser Ser Glu  Val Glu Ala Leu Arg  Arg Gln Leu 
    1655                 1660                 1665             


Leu Gln  Glu Gln Glu Ser Val  Lys Gln Ala His Leu  Arg Asn Glu 
    1670                 1675                 1680             


His Phe  Gln Lys Ala Ile Glu  Asp Lys Ser Arg Ser  Leu Asn Glu 
    1685                 1690                 1695             


Ser Lys  Ile Glu Ile Glu Arg  Leu Gln Ser Leu Thr  Glu Asn Leu 
    1700                 1705                 1710             


Thr Lys  Glu His Leu Met Leu  Glu Glu Glu Leu Arg  Asn Leu Arg 
    1715                 1720                 1725             


Leu Glu  Tyr Asp Asp Leu Arg  Arg Gly Arg Ser Glu  Ala Asp Ser 
    1730                 1735                 1740             


Asp Lys  Asn Ala Thr Ile Leu  Glu Leu Arg Ser Gln  Leu Gln Ile 
    1745                 1750                 1755             


Ser Asn  Asn Arg Thr Leu Glu  Leu Gln Gly Leu Ile  Asn Asp Leu 
    1760                 1765                 1770             


Gln Arg  Glu Arg Glu Asn Leu  Arg Gln Glu Ile Glu  Lys Phe Gln 
    1775                 1780                 1785             


Lys Gln  Ala Leu Glu Ala Ser  Asn Arg Ile Gln Glu  Ser Lys Asn 
    1790                 1795                 1800             


Gln Cys  Thr Gln Val Val Gln  Glu Arg Glu Ser Leu  Leu Val Lys 
    1805                 1810                 1815             


Ile Lys  Val Leu Glu Gln Asp  Lys Ala Arg Leu Gln  Arg Leu Glu 
    1820                 1825                 1830             


Asp Glu  Leu Asn Arg Ala Lys  Ser Thr Leu Glu Ala  Glu Thr Arg 
    1835                 1840                 1845             


Val Lys  Gln Arg Leu Glu Cys  Glu Lys Gln Gln Ile  Gln Asn Asp 
    1850                 1855                 1860             


Leu Asn  Gln Trp Lys Thr Gln  Tyr Ser Arg Lys Glu  Glu Ala Ile 
    1865                 1870                 1875             


Arg Lys  Ile Glu Ser Glu Arg  Glu Lys Ser Glu Arg  Glu Lys Asn 
    1880                 1885                 1890             


Ser Leu  Arg Ser Glu Ile Glu  Arg Leu Gln Ala Glu  Ile Lys Arg 
    1895                 1900                 1905             


Ile Glu  Glu Arg Cys Arg Arg  Lys Leu Glu Asp Ser  Thr Arg Glu 
    1910                 1915                 1920             


Thr Gln  Ser Gln Leu Glu Thr  Glu Arg Ser Arg Tyr  Gln Arg Glu 
    1925                 1930                 1935             


Ile Asp  Lys Leu Arg Gln Arg  Pro Tyr Gly Ser His  Arg Glu Thr 
    1940                 1945                 1950             


Gln Thr  Glu Cys Glu Trp Thr  Val Asp Thr Ser Lys  Leu Val Phe 
    1955                 1960                 1965             


Asp Gly  Leu Arg Lys Lys Val  Thr Ala Met Gln Leu  Tyr Glu Cys 
    1970                 1975                 1980             


Gln Leu  Ile Asp Lys Thr Thr  Leu Asp Lys Leu Leu  Lys Gly Lys 
    1985                 1990                 1995             


Lys Ser  Val Glu Glu Val Ala  Ser Glu Ile Gln Pro  Phe Leu Arg 
    2000                 2005                 2010             


Gly Ala  Gly Ser Ile Ala Gly  Ala Ser Ala Ser Pro  Lys Glu Lys 
    2015                 2020                 2025             


Tyr Ser  Leu Val Glu Ala Lys  Arg Lys Lys Leu Ile  Ser Pro Glu 
    2030                 2035                 2040             


Ser Thr  Val Met Leu Leu Glu  Ala Gln Ala Ala Thr  Gly Gly Ile 
    2045                 2050                 2055             


Ile Asp  Pro His Arg Asn Glu  Lys Leu Thr Val Asp  Ser Ala Ile 
    2060                 2065                 2070             


Ala Arg  Asp Leu Ile Asp Phe  Asp Asp Arg Gln Gln  Ile Tyr Ala 
    2075                 2080                 2085             


Ala Glu  Lys Ala Ile Thr Gly  Phe Asp Asp Pro Phe  Ser Gly Lys 
    2090                 2095                 2100             


Thr Val  Ser Val Ser Glu Ala  Ile Lys Lys Asn Leu  Ile Asp Arg 
    2105                 2110                 2115             


Glu Thr  Gly Met Arg Leu Leu  Glu Ala Gln Ile Ala  Ser Gly Gly 
    2120                 2125                 2130             


Val Val  Asp Pro Val Asn Ser  Val Phe Leu Pro Lys  Asp Val Ala 
    2135                 2140                 2145             


Leu Ala  Arg Gly Leu Ile Asp  Arg Asp Leu Tyr Arg  Ser Leu Asn 
    2150                 2155                 2160             


Asp Pro  Arg Asp Ser Gln Lys  Asn Phe Val Asp Pro  Val Thr Lys 
    2165                 2170                 2175             


Lys Lys  Val Ser Tyr Val Gln  Leu Lys Glu Arg Cys  Arg Ile Glu 
    2180                 2185                 2190             


Pro His  Thr Gly Leu Leu Leu  Leu Ser Val Gln Lys  Arg Ser Met 
    2195                 2200                 2205             


Ser Phe  Gln Gly Ile Arg Gln  Pro Val Thr Val Thr  Glu Leu Val 
    2210                 2215                 2220             


Asp Ser  Gly Ile Leu Arg Pro  Ser Thr Val Asn Glu  Leu Glu Ser 
    2225                 2230                 2235             


Gly Gln  Ile Ser Tyr Asp Glu  Val Gly Glu Arg Ile  Lys Asp Phe 
    2240                 2245                 2250             


Leu Gln  Gly Ser Ser Cys Ile  Ala Gly Ile Tyr Asn  Glu Thr Thr 
    2255                 2260                 2265             


Lys Gln  Lys Leu Gly Ile Tyr  Glu Ala Met Lys Ile  Gly Leu Val 
    2270                 2275                 2280             


Arg Pro  Gly Thr Ala Leu Glu  Leu Leu Glu Ala Gln  Ala Ala Thr 
    2285                 2290                 2295             


Gly Phe  Ile Val Asp Pro Val  Ser Asn Leu Arg Leu  Pro Val Glu 
    2300                 2305                 2310             


Glu Ala  Tyr Lys Arg Gly Leu  Val Gly Ile Glu Phe  Lys Glu Lys 
    2315                 2320                 2325             


Leu Leu  Ser Ala Glu Arg Ala  Val Thr Gly Tyr Asn  Asp Pro Glu 
    2330                 2335                 2340             


Thr Gly  Asn Ile Ile Ser Leu  Phe Gln Ala Met Asn  Lys Glu Leu 
    2345                 2350                 2355             


Ile Glu  Lys Gly His Gly Ile  Arg Leu Leu Glu Ala  Gln Ile Ala 
    2360                 2365                 2370             


Thr Gly  Gly Ile Ile Asp Pro  Lys Glu Ser His Arg  Leu Pro Val 
    2375                 2380                 2385             


Asp Ile  Ala Tyr Lys Arg Gly  Tyr Phe Asn Glu Glu  Leu Ser Glu 
    2390                 2395                 2400             


Ile Leu  Ser Asp Pro Ser Asp  Asp Thr Lys Gly Phe  Phe Asp Pro 
    2405                 2410                 2415             


Asn Thr  Glu Glu Asn Leu Thr  Tyr Leu Gln Leu Lys  Glu Arg Cys 
    2420                 2425                 2430             


Ile Lys  Asp Glu Glu Thr Gly  Leu Cys Leu Leu Pro  Leu Lys Glu 
    2435                 2440                 2445             


Lys Lys  Lys Gln Val Gln Thr  Ser Gln Lys Asn Thr  Leu Arg Lys 
    2450                 2455                 2460             


Arg Arg  Val Val Ile Val Asp  Pro Glu Thr Asn Lys  Glu Met Ser 
    2465                 2470                 2475             


Val Gln  Glu Ala Tyr Lys Lys  Gly Leu Ile Asp Tyr  Glu Thr Phe 
    2480                 2485                 2490             


Lys Glu  Leu Cys Glu Gln Glu  Cys Glu Trp Glu Glu  Ile Thr Ile 
    2495                 2500                 2505             


Thr Gly  Ser Asp Gly Ser Thr  Arg Val Val Leu Val  Asp Arg Lys 
    2510                 2515                 2520             


Thr Gly  Ser Gln Tyr Asp Ile  Gln Asp Ala Ile Asp  Lys Gly Leu 
    2525                 2530                 2535             


Val Asp  Arg Lys Phe Phe Asp  Gln Tyr Arg Ser Gly  Ser Leu Ser 
    2540                 2545                 2550             


Leu Thr  Gln Phe Ala Asp Met  Ile Ser Leu Lys Asn  Gly Val Gly 
    2555                 2560                 2565             


Thr Ser  Ser Ser Met Gly Ser  Gly Val Ser Asp Asp  Val Phe Ser 
    2570                 2575                 2580             


Ser Ser  Arg His Glu Ser Val  Ser Lys Ile Ser Thr  Ile Ser Ser 
    2585                 2590                 2595             


Val Arg  Asn Leu Thr Ile Arg  Ser Ser Ser Phe Ser  Asp Thr Leu 
    2600                 2605                 2610             


Glu Glu  Ser Ser Pro Ile Ala  Ala Ile Phe Asp Thr  Glu Asn Leu 
    2615                 2620                 2625             


Glu Lys  Ile Ser Ile Thr Glu  Gly Ile Glu Arg Gly  Ile Val Asp 
    2630                 2635                 2640             


Ser Ile  Thr Gly Gln Arg Leu  Leu Glu Ala Gln Ala  Cys Thr Gly 
    2645                 2650                 2655             


Gly Ile  Ile His Pro Thr Thr  Gly Gln Lys Leu Ser  Leu Gln Asp 
    2660                 2665                 2670             


Ala Val  Ser Gln Gly Val Ile  Asp Gln Asp Met Ala  Thr Arg Leu 
    2675                 2680                 2685             


Lys Pro  Ala Gln Lys Ala Phe  Ile Gly Phe Glu Gly  Val Lys Gly 
    2690                 2695                 2700             


Lys Lys  Lys Met Ser Ala Ala  Glu Ala Val Lys Glu  Lys Trp Leu 
    2705                 2710                 2715             


Pro Tyr  Glu Ala Gly Gln Arg  Phe Leu Glu Phe Gln  Tyr Leu Thr 
    2720                 2725                 2730             


Gly Gly  Leu Val Asp Pro Glu  Val His Gly Arg Ile  Ser Thr Glu 
    2735                 2740                 2745             


Glu Ala  Ile Arg Lys Gly Phe  Ile Asp Gly Arg Ala  Ala Gln Arg 
    2750                 2755                 2760             


Leu Gln  Asp Thr Ser Ser Tyr  Ala Lys Ile Leu Thr  Cys Pro Lys 
    2765                 2770                 2775             


Thr Lys  Leu Lys Ile Ser Tyr  Lys Asp Ala Ile Asn  Arg Ser Met 
    2780                 2785                 2790             


Val Glu  Asp Ile Thr Gly Leu  Arg Leu Leu Glu Ala  Ala Ser Val 
    2795                 2800                 2805             


Ser Ser  Lys Gly Leu Pro Ser  Pro Tyr Asn Met Ser  Ser Ala Pro 
    2810                 2815                 2820             


Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser Arg Ser  Gly Ser Arg 
    2825                 2830                 2835             


Ser Gly  Ser Arg Ser Gly Ser  Arg Arg Gly Ser Phe  Asp Ala Thr 
    2840                 2845                 2850             


Gly Asn  Ser Ser Tyr Ser Tyr  Ser Tyr Ser Phe Ser  Ser Ser Ser 
    2855                 2860                 2865             


Ile Gly  His 
    2870     


<210>  2
<211>  2272
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Desmoplakin isoform 2

<400>  2

Met Ser Cys Asn Gly Gly Ser His Pro Arg Ile Asn Thr Leu Gly Arg 
1               5                   10                  15      


Met Ile Arg Ala Glu Ser Gly Pro Asp Leu Arg Tyr Glu Val Thr Ser 
            20                  25                  30          


Gly Gly Gly Gly Thr Ser Arg Met Tyr Tyr Ser Arg Arg Gly Val Ile 
        35                  40                  45              


Thr Asp Gln Asn Ser Asp Gly Tyr Cys Gln Thr Gly Thr Met Ser Arg 
    50                  55                  60                  


His Gln Asn Gln Asn Thr Ile Gln Glu Leu Leu Gln Asn Cys Ser Asp 
65                  70                  75                  80  


Cys Leu Met Arg Ala Glu Leu Ile Val Gln Pro Glu Leu Lys Tyr Gly 
                85                  90                  95      


Asp Gly Ile Gln Leu Thr Arg Ser Arg Glu Leu Asp Glu Cys Phe Ala 
            100                 105                 110         


Gln Ala Asn Asp Gln Met Glu Ile Leu Asp Ser Leu Ile Arg Glu Met 
        115                 120                 125             


Arg Gln Met Gly Gln Pro Cys Asp Ala Tyr Gln Lys Arg Leu Leu Gln 
    130                 135                 140                 


Leu Gln Glu Gln Met Arg Ala Leu Tyr Lys Ala Ile Ser Val Pro Arg 
145                 150                 155                 160 


Val Arg Arg Ala Ser Ser Lys Gly Gly Gly Gly Tyr Thr Cys Gln Ser 
                165                 170                 175     


Gly Ser Gly Trp Asp Glu Phe Thr Lys His Val Thr Ser Glu Cys Leu 
            180                 185                 190         


Gly Trp Met Arg Gln Gln Arg Ala Glu Met Asp Met Val Ala Trp Gly 
        195                 200                 205             


Val Asp Leu Ala Ser Val Glu Gln His Ile Asn Ser His Arg Gly Ile 
    210                 215                 220                 


His Asn Ser Ile Gly Asp Tyr Arg Trp Gln Leu Asp Lys Ile Lys Ala 
225                 230                 235                 240 


Asp Leu Arg Glu Lys Ser Ala Ile Tyr Gln Leu Glu Glu Glu Tyr Glu 
                245                 250                 255     


Asn Leu Leu Lys Ala Ser Phe Glu Arg Met Asp His Leu Arg Gln Leu 
            260                 265                 270         


Gln Asn Ile Ile Gln Ala Thr Ser Arg Glu Ile Met Trp Ile Asn Asp 
        275                 280                 285             


Cys Glu Glu Glu Glu Leu Leu Tyr Asp Trp Ser Asp Lys Asn Thr Asn 
    290                 295                 300                 


Ile Ala Gln Lys Gln Glu Ala Phe Ser Ile Arg Met Ser Gln Leu Glu 
305                 310                 315                 320 


Val Lys Glu Lys Glu Leu Asn Lys Leu Lys Gln Glu Ser Asp Gln Leu 
                325                 330                 335     


Val Leu Asn Gln His Pro Ala Ser Asp Lys Ile Glu Ala Tyr Met Asp 
            340                 345                 350         


Thr Leu Gln Thr Gln Trp Ser Trp Ile Leu Gln Ile Thr Lys Cys Ile 
        355                 360                 365             


Asp Val His Leu Lys Glu Asn Ala Ala Tyr Phe Gln Phe Phe Glu Glu 
    370                 375                 380                 


Ala Gln Ser Thr Glu Ala Tyr Leu Lys Gly Leu Gln Asp Ser Ile Arg 
385                 390                 395                 400 


Lys Lys Tyr Pro Cys Asp Lys Asn Met Pro Leu Gln His Leu Leu Glu 
                405                 410                 415     


Gln Ile Lys Glu Leu Glu Lys Glu Arg Glu Lys Ile Leu Glu Tyr Lys 
            420                 425                 430         


Arg Gln Val Gln Asn Leu Val Asn Lys Ser Lys Lys Ile Val Gln Leu 
        435                 440                 445             


Lys Pro Arg Asn Pro Asp Tyr Arg Ser Asn Lys Pro Ile Ile Leu Arg 
    450                 455                 460                 


Ala Leu Cys Asp Tyr Lys Gln Asp Gln Lys Ile Val His Lys Gly Asp 
465                 470                 475                 480 


Glu Cys Ile Leu Lys Asp Asn Asn Glu Arg Ser Lys Trp Tyr Val Thr 
                485                 490                 495     


Gly Pro Gly Gly Val Asp Met Leu Val Pro Ser Val Gly Leu Ile Ile 
            500                 505                 510         


Pro Pro Pro Asn Pro Leu Ala Val Asp Leu Ser Cys Lys Ile Glu Gln 
        515                 520                 525             


Tyr Tyr Glu Ala Ile Leu Ala Leu Trp Asn Gln Leu Tyr Ile Asn Met 
    530                 535                 540                 


Lys Ser Leu Val Ser Trp His Tyr Cys Met Ile Asp Ile Glu Lys Ile 
545                 550                 555                 560 


Arg Ala Met Thr Ile Ala Lys Leu Lys Thr Met Arg Gln Glu Asp Tyr 
                565                 570                 575     


Met Lys Thr Ile Ala Asp Leu Glu Leu His Tyr Gln Glu Phe Ile Arg 
            580                 585                 590         


Asn Ser Gln Gly Ser Glu Met Phe Gly Asp Asp Asp Lys Arg Lys Ile 
        595                 600                 605             


Gln Ser Gln Phe Thr Asp Ala Gln Lys His Tyr Gln Thr Leu Val Ile 
    610                 615                 620                 


Gln Leu Pro Gly Tyr Pro Gln His Gln Thr Val Thr Thr Thr Glu Ile 
625                 630                 635                 640 


Thr His His Gly Thr Cys Gln Asp Val Asn His Asn Lys Val Ile Glu 
                645                 650                 655     


Thr Asn Arg Glu Asn Asp Lys Gln Glu Thr Trp Met Leu Met Glu Leu 
            660                 665                 670         


Gln Lys Ile Arg Arg Gln Ile Glu His Cys Glu Gly Arg Met Thr Leu 
        675                 680                 685             


Lys Asn Leu Pro Leu Ala Asp Gln Gly Ser Ser His His Ile Thr Val 
    690                 695                 700                 


Lys Ile Asn Glu Leu Lys Ser Val Gln Asn Asp Ser Gln Ala Ile Ala 
705                 710                 715                 720 


Glu Val Leu Asn Gln Leu Lys Asp Met Leu Ala Asn Phe Arg Gly Ser 
                725                 730                 735     


Glu Lys Tyr Cys Tyr Leu Gln Asn Glu Val Phe Gly Leu Phe Gln Lys 
            740                 745                 750         


Leu Glu Asn Ile Asn Gly Val Thr Asp Gly Tyr Leu Asn Ser Leu Cys 
        755                 760                 765             


Thr Val Arg Ala Leu Leu Gln Ala Ile Leu Gln Thr Glu Asp Met Leu 
    770                 775                 780                 


Lys Val Tyr Glu Ala Arg Leu Thr Glu Glu Glu Thr Val Cys Leu Asp 
785                 790                 795                 800 


Leu Asp Lys Val Glu Ala Tyr Arg Cys Gly Leu Lys Lys Ile Lys Asn 
                805                 810                 815     


Asp Leu Asn Leu Lys Lys Ser Leu Leu Ala Thr Met Lys Thr Glu Leu 
            820                 825                 830         


Gln Lys Ala Gln Gln Ile His Ser Gln Thr Ser Gln Gln Tyr Pro Leu 
        835                 840                 845             


Tyr Asp Leu Asp Leu Gly Lys Phe Gly Glu Lys Val Thr Gln Leu Thr 
    850                 855                 860                 


Asp Arg Trp Gln Arg Ile Asp Lys Gln Ile Asp Phe Arg Leu Trp Asp 
865                 870                 875                 880 


Leu Glu Lys Gln Ile Lys Gln Leu Arg Asn Tyr Arg Asp Asn Tyr Gln 
                885                 890                 895     


Ala Phe Cys Lys Trp Leu Tyr Asp Ala Lys Arg Arg Gln Asp Ser Leu 
            900                 905                 910         


Glu Ser Met Lys Phe Gly Asp Ser Asn Thr Val Met Arg Phe Leu Asn 
        915                 920                 925             


Glu Gln Lys Asn Leu His Ser Glu Ile Ser Gly Lys Arg Asp Lys Ser 
    930                 935                 940                 


Glu Glu Val Gln Lys Ile Ala Glu Leu Cys Ala Asn Ser Ile Lys Asp 
945                 950                 955                 960 


Tyr Glu Leu Gln Leu Ala Ser Tyr Thr Ser Gly Leu Glu Thr Leu Leu 
                965                 970                 975     


Asn Ile Pro Ile Lys Arg Thr Met Ile Gln Ser Pro Ser Gly Val Ile 
            980                 985                 990         


Leu Gln Glu Ala Ala Asp Val His  Ala Arg Tyr Ile Glu  Leu Leu Thr 
        995                 1000                 1005             


Arg Ser  Gly Asp Tyr Tyr Arg  Phe Leu Ser Glu Met  Leu Lys Ser 
    1010                 1015                 1020             


Leu Glu  Asp Leu Lys Leu Lys  Asn Thr Lys Ile Glu  Val Leu Glu 
    1025                 1030                 1035             


Glu Glu  Leu Arg Leu Ala Arg  Asp Ala Asn Ser Glu  Asn Cys Asn 
    1040                 1045                 1050             


Lys Asn  Lys Phe Leu Asp Gln  Asn Leu Gln Lys Tyr  Gln Ala Glu 
    1055                 1060                 1065             


Cys Ser  Gln Phe Lys Ala Lys  Leu Ala Ser Leu Glu  Glu Leu Lys 
    1070                 1075                 1080             


Arg Gln  Ala Glu Leu Asp Gly  Lys Ser Ala Lys Gln  Asn Leu Asp 
    1085                 1090                 1095             


Lys Cys  Tyr Gly Gln Ile Lys  Glu Leu Asn Glu Lys  Ile Thr Arg 
    1100                 1105                 1110             


Leu Thr  Tyr Glu Ile Glu Asp  Glu Lys Arg Arg Arg  Lys Ser Val 
    1115                 1120                 1125             


Glu Asp  Arg Phe Asp Gln Gln  Lys Asn Asp Tyr Asp  Gln Leu Gln 
    1130                 1135                 1140             


Lys Ala  Arg Gln Cys Glu Lys  Glu Asn Leu Gly Trp  Gln Lys Leu 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ala Ile Lys  Glu Lys Glu Tyr Glu  Ile Glu Arg 
    1160                 1165                 1170             


Leu Arg  Val Leu Leu Gln Glu  Glu Gly Thr Arg Lys  Arg Glu Tyr 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ala Lys Ala  Ser Asn Arg Ile Gln  Glu Ser Lys 
    1190                 1195                 1200             


Asn Gln  Cys Thr Gln Val Val  Gln Glu Arg Glu Ser  Leu Leu Val 
    1205                 1210                 1215             


Lys Ile  Lys Val Leu Glu Gln  Asp Lys Ala Arg Leu  Gln Arg Leu 
    1220                 1225                 1230             


Glu Asp  Glu Leu Asn Arg Ala  Lys Ser Thr Leu Glu  Ala Glu Thr 
    1235                 1240                 1245             


Arg Val  Lys Gln Arg Leu Glu  Cys Glu Lys Gln Gln  Ile Gln Asn 
    1250                 1255                 1260             


Asp Leu  Asn Gln Trp Lys Thr  Gln Tyr Ser Arg Lys  Glu Glu Ala 
    1265                 1270                 1275             


Ile Arg  Lys Ile Glu Ser Glu  Arg Glu Lys Ser Glu  Arg Glu Lys 
    1280                 1285                 1290             


Asn Ser  Leu Arg Ser Glu Ile  Glu Arg Leu Gln Ala  Glu Ile Lys 
    1295                 1300                 1305             


Arg Ile  Glu Glu Arg Cys Arg  Arg Lys Leu Glu Asp  Ser Thr Arg 
    1310                 1315                 1320             


Glu Thr  Gln Ser Gln Leu Glu  Thr Glu Arg Ser Arg  Tyr Gln Arg 
    1325                 1330                 1335             


Glu Ile  Asp Lys Leu Arg Gln  Arg Pro Tyr Gly Ser  His Arg Glu 
    1340                 1345                 1350             


Thr Gln  Thr Glu Cys Glu Trp  Thr Val Asp Thr Ser  Lys Leu Val 
    1355                 1360                 1365             


Phe Asp  Gly Leu Arg Lys Lys  Val Thr Ala Met Gln  Leu Tyr Glu 
    1370                 1375                 1380             


Cys Gln  Leu Ile Asp Lys Thr  Thr Leu Asp Lys Leu  Leu Lys Gly 
    1385                 1390                 1395             


Lys Lys  Ser Val Glu Glu Val  Ala Ser Glu Ile Gln  Pro Phe Leu 
    1400                 1405                 1410             


Arg Gly  Ala Gly Ser Ile Ala  Gly Ala Ser Ala Ser  Pro Lys Glu 
    1415                 1420                 1425             


Lys Tyr  Ser Leu Val Glu Ala  Lys Arg Lys Lys Leu  Ile Ser Pro 
    1430                 1435                 1440             


Glu Ser  Thr Val Met Leu Leu  Glu Ala Gln Ala Ala  Thr Gly Gly 
    1445                 1450                 1455             


Ile Ile  Asp Pro His Arg Asn  Glu Lys Leu Thr Val  Asp Ser Ala 
    1460                 1465                 1470             


Ile Ala  Arg Asp Leu Ile Asp  Phe Asp Asp Arg Gln  Gln Ile Tyr 
    1475                 1480                 1485             


Ala Ala  Glu Lys Ala Ile Thr  Gly Phe Asp Asp Pro  Phe Ser Gly 
    1490                 1495                 1500             


Lys Thr  Val Ser Val Ser Glu  Ala Ile Lys Lys Asn  Leu Ile Asp 
    1505                 1510                 1515             


Arg Glu  Thr Gly Met Arg Leu  Leu Glu Ala Gln Ile  Ala Ser Gly 
    1520                 1525                 1530             


Gly Val  Val Asp Pro Val Asn  Ser Val Phe Leu Pro  Lys Asp Val 
    1535                 1540                 1545             


Ala Leu  Ala Arg Gly Leu Ile  Asp Arg Asp Leu Tyr  Arg Ser Leu 
    1550                 1555                 1560             


Asn Asp  Pro Arg Asp Ser Gln  Lys Asn Phe Val Asp  Pro Val Thr 
    1565                 1570                 1575             


Lys Lys  Lys Val Ser Tyr Val  Gln Leu Lys Glu Arg  Cys Arg Ile 
    1580                 1585                 1590             


Glu Pro  His Thr Gly Leu Leu  Leu Leu Ser Val Gln  Lys Arg Ser 
    1595                 1600                 1605             


Met Ser  Phe Gln Gly Ile Arg  Gln Pro Val Thr Val  Thr Glu Leu 
    1610                 1615                 1620             


Val Asp  Ser Gly Ile Leu Arg  Pro Ser Thr Val Asn  Glu Leu Glu 
    1625                 1630                 1635             


Ser Gly  Gln Ile Ser Tyr Asp  Glu Val Gly Glu Arg  Ile Lys Asp 
    1640                 1645                 1650             


Phe Leu  Gln Gly Ser Ser Cys  Ile Ala Gly Ile Tyr  Asn Glu Thr 
    1655                 1660                 1665             


Thr Lys  Gln Lys Leu Gly Ile  Tyr Glu Ala Met Lys  Ile Gly Leu 
    1670                 1675                 1680             


Val Arg  Pro Gly Thr Ala Leu  Glu Leu Leu Glu Ala  Gln Ala Ala 
    1685                 1690                 1695             


Thr Gly  Phe Ile Val Asp Pro  Val Ser Asn Leu Arg  Leu Pro Val 
    1700                 1705                 1710             


Glu Glu  Ala Tyr Lys Arg Gly  Leu Val Gly Ile Glu  Phe Lys Glu 
    1715                 1720                 1725             


Lys Leu  Leu Ser Ala Glu Arg  Ala Val Thr Gly Tyr  Asn Asp Pro 
    1730                 1735                 1740             


Glu Thr  Gly Asn Ile Ile Ser  Leu Phe Gln Ala Met  Asn Lys Glu 
    1745                 1750                 1755             


Leu Ile  Glu Lys Gly His Gly  Ile Arg Leu Leu Glu  Ala Gln Ile 
    1760                 1765                 1770             


Ala Thr  Gly Gly Ile Ile Asp  Pro Lys Glu Ser His  Arg Leu Pro 
    1775                 1780                 1785             


Val Asp  Ile Ala Tyr Lys Arg  Gly Tyr Phe Asn Glu  Glu Leu Ser 
    1790                 1795                 1800             


Glu Ile  Leu Ser Asp Pro Ser  Asp Asp Thr Lys Gly  Phe Phe Asp 
    1805                 1810                 1815             


Pro Asn  Thr Glu Glu Asn Leu  Thr Tyr Leu Gln Leu  Lys Glu Arg 
    1820                 1825                 1830             


Cys Ile  Lys Asp Glu Glu Thr  Gly Leu Cys Leu Leu  Pro Leu Lys 
    1835                 1840                 1845             


Glu Lys  Lys Lys Gln Val Gln  Thr Ser Gln Lys Asn  Thr Leu Arg 
    1850                 1855                 1860             


Lys Arg  Arg Val Val Ile Val  Asp Pro Glu Thr Asn  Lys Glu Met 
    1865                 1870                 1875             


Ser Val  Gln Glu Ala Tyr Lys  Lys Gly Leu Ile Asp  Tyr Glu Thr 
    1880                 1885                 1890             


Phe Lys  Glu Leu Cys Glu Gln  Glu Cys Glu Trp Glu  Glu Ile Thr 
    1895                 1900                 1905             


Ile Thr  Gly Ser Asp Gly Ser  Thr Arg Val Val Leu  Val Asp Arg 
    1910                 1915                 1920             


Lys Thr  Gly Ser Gln Tyr Asp  Ile Gln Asp Ala Ile  Asp Lys Gly 
    1925                 1930                 1935             


Leu Val  Asp Arg Lys Phe Phe  Asp Gln Tyr Arg Ser  Gly Ser Leu 
    1940                 1945                 1950             


Ser Leu  Thr Gln Phe Ala Asp  Met Ile Ser Leu Lys  Asn Gly Val 
    1955                 1960                 1965             


Gly Thr  Ser Ser Ser Met Gly  Ser Gly Val Ser Asp  Asp Val Phe 
    1970                 1975                 1980             


Ser Ser  Ser Arg His Glu Ser  Val Ser Lys Ile Ser  Thr Ile Ser 
    1985                 1990                 1995             


Ser Val  Arg Asn Leu Thr Ile  Arg Ser Ser Ser Phe  Ser Asp Thr 
    2000                 2005                 2010             


Leu Glu  Glu Ser Ser Pro Ile  Ala Ala Ile Phe Asp  Thr Glu Asn 
    2015                 2020                 2025             


Leu Glu  Lys Ile Ser Ile Thr  Glu Gly Ile Glu Arg  Gly Ile Val 
    2030                 2035                 2040             


Asp Ser  Ile Thr Gly Gln Arg  Leu Leu Glu Ala Gln  Ala Cys Thr 
    2045                 2050                 2055             


Gly Gly  Ile Ile His Pro Thr  Thr Gly Gln Lys Leu  Ser Leu Gln 
    2060                 2065                 2070             


Asp Ala  Val Ser Gln Gly Val  Ile Asp Gln Asp Met  Ala Thr Arg 
    2075                 2080                 2085             


Leu Lys  Pro Ala Gln Lys Ala  Phe Ile Gly Phe Glu  Gly Val Lys 
    2090                 2095                 2100             


Gly Lys  Lys Lys Met Ser Ala  Ala Glu Ala Val Lys  Glu Lys Trp 
    2105                 2110                 2115             


Leu Pro  Tyr Glu Ala Gly Gln  Arg Phe Leu Glu Phe  Gln Tyr Leu 
    2120                 2125                 2130             


Thr Gly  Gly Leu Val Asp Pro  Glu Val His Gly Arg  Ile Ser Thr 
    2135                 2140                 2145             


Glu Glu  Ala Ile Arg Lys Gly  Phe Ile Asp Gly Arg  Ala Ala Gln 
    2150                 2155                 2160             


Arg Leu  Gln Asp Thr Ser Ser  Tyr Ala Lys Ile Leu  Thr Cys Pro 
    2165                 2170                 2175             


Lys Thr  Lys Leu Lys Ile Ser  Tyr Lys Asp Ala Ile  Asn Arg Ser 
    2180                 2185                 2190             


Met Val  Glu Asp Ile Thr Gly  Leu Arg Leu Leu Glu  Ala Ala Ser 
    2195                 2200                 2205             


Val Ser  Ser Lys Gly Leu Pro  Ser Pro Tyr Asn Met  Ser Ser Ala 
    2210                 2215                 2220             


Pro Gly  Ser Arg Ser Gly Ser  Arg Ser Gly Ser Arg  Ser Gly Ser 
    2225                 2230                 2235             


Arg Ser  Gly Ser Arg Ser Gly  Ser Arg Arg Gly Ser  Phe Asp Ala 
    2240                 2245                 2250             


Thr Gly  Asn Ser Ser Tyr Ser  Tyr Ser Tyr Ser Phe  Ser Ser Ser 
    2255                 2260                 2265             


Ser Ile  Gly His 
    2270         


<210>  3
<211>  439
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Rho GTPase-activating protein 1

<400>  3

Met Asp Pro Leu Ser Glu Leu Gln Asp Asp Leu Thr Leu Asp Asp Thr 
1               5                   10                  15      


Ser Glu Ala Leu Asn Gln Leu Lys Leu Ala Ser Ile Asp Glu Lys Asn 
            20                  25                  30          


Trp Pro Ser Asp Glu Met Pro Asp Phe Pro Lys Ser Asp Asp Ser Lys 
        35                  40                  45              


Ser Ser Ser Pro Glu Leu Val Thr His Leu Lys Trp Asp Asp Pro Tyr 
    50                  55                  60                  


Tyr Asp Ile Ala Arg His Gln Ile Val Glu Val Ala Gly Asp Asp Lys 
65                  70                  75                  80  


Tyr Gly Arg Lys Ile Ile Val Phe Ser Ala Cys Arg Met Pro Pro Ser 
                85                  90                  95      


His Gln Leu Asp His Ser Lys Leu Leu Gly Tyr Leu Lys His Thr Leu 
            100                 105                 110         


Asp Gln Tyr Val Glu Ser Asp Tyr Thr Leu Leu Tyr Leu His His Gly 
        115                 120                 125             


Leu Thr Ser Asp Asn Lys Pro Ser Leu Ser Trp Leu Arg Asp Ala Tyr 
    130                 135                 140                 


Arg Glu Phe Asp Arg Lys Tyr Lys Lys Asn Ile Lys Ala Leu Tyr Ile 
145                 150                 155                 160 


Val His Pro Thr Met Phe Ile Lys Thr Leu Leu Ile Leu Phe Lys Pro 
                165                 170                 175     


Leu Ile Ser Phe Lys Phe Gly Gln Lys Ile Phe Tyr Val Asn Tyr Leu 
            180                 185                 190         


Ser Glu Leu Ser Glu His Val Lys Leu Glu Gln Leu Gly Ile Pro Arg 
        195                 200                 205             


Gln Val Leu Lys Tyr Asp Asp Phe Leu Lys Ser Thr Gln Lys Ser Pro 
    210                 215                 220                 


Ala Thr Ala Pro Lys Pro Met Pro Pro Arg Pro Pro Leu Pro Asn Gln 
225                 230                 235                 240 


Gln Phe Gly Val Ser Leu Gln His Leu Gln Glu Lys Asn Pro Glu Gln 
                245                 250                 255     


Glu Pro Ile Pro Ile Val Leu Arg Glu Thr Val Ala Tyr Leu Gln Ala 
            260                 265                 270         


His Ala Leu Thr Thr Glu Gly Ile Phe Arg Arg Ser Ala Asn Thr Gln 
        275                 280                 285             


Val Val Arg Glu Val Gln Gln Lys Tyr Asn Met Gly Leu Pro Val Asp 
    290                 295                 300                 


Phe Asp Gln Tyr Asn Glu Leu His Leu Pro Ala Val Ile Leu Lys Thr 
305                 310                 315                 320 


Phe Leu Arg Glu Leu Pro Glu Pro Leu Leu Thr Phe Asp Leu Tyr Pro 
                325                 330                 335     


His Val Val Gly Phe Leu Asn Ile Asp Glu Ser Gln Arg Val Pro Ala 
            340                 345                 350         


Thr Leu Gln Val Leu Gln Thr Leu Pro Glu Glu Asn Tyr Gln Val Leu 
        355                 360                 365             


Arg Phe Leu Thr Ala Phe Leu Val Gln Ile Ser Ala His Ser Asp Gln 
    370                 375                 380                 


Asn Lys Met Thr Asn Thr Asn Leu Ala Val Val Phe Gly Pro Asn Leu 
385                 390                 395                 400 


Leu Trp Ala Lys Asp Ala Ala Ile Thr Leu Lys Ala Ile Asn Pro Ile 
                405                 410                 415     


Asn Thr Phe Thr Lys Phe Leu Leu Asp His Gln Gly Glu Leu Phe Pro 
            420                 425                 430         


Ser Pro Asp Pro Ser Gly Leu 
        435                 


<210>  4
<211>  5090
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Epiplakin

<400>  4

Met Ser Gly His Thr Leu Pro Pro Leu Pro Val Pro Gly Thr Asn Ser 
1               5                   10                  15      


Thr Glu Gln Ala Ser Val Pro Arg Ala Met Ala Ala Thr Leu Gly Ala 
            20                  25                  30          


Gly Thr Pro Pro Arg Pro Gln Ala Arg Ser Ile Ala Gly Val Tyr Val 
        35                  40                  45              


Glu Ala Ser Gly Gln Ala Gln Ser Val Tyr Ala Ala Met Glu Gln Gly 
    50                  55                  60                  


Leu Leu Pro Ala Gly Leu Gly Gln Ala Leu Leu Glu Ala Gln Ala Ala 
65                  70                  75                  80  


Thr Gly Gly Leu Val Asp Leu Ala Arg Gly Gln Leu Leu Pro Val Ser 
                85                  90                  95      


Lys Ala Leu Gln Gln Gly Leu Val Gly Leu Glu Leu Lys Glu Lys Leu 
            100                 105                 110         


Leu Ala Ala Glu Arg Ala Thr Thr Gly Tyr Pro Asp Pro Tyr Gly Gly 
        115                 120                 125             


Glu Lys Leu Ala Leu Phe Gln Ala Ile Gly Lys Glu Val Val Asp Arg 
    130                 135                 140                 


Ala Leu Gly Gln Ser Trp Leu Glu Val Gln Leu Ala Thr Gly Gly Leu 
145                 150                 155                 160 


Val Asp Pro Ala Gln Gly Val Leu Val Ala Pro Glu Pro Ala Cys His 
                165                 170                 175     


Gln Gly Leu Leu Asp Arg Glu Thr Trp His Lys Leu Ser Glu Leu Glu 
            180                 185                 190         


Pro Gly Thr Gly Asp Leu Arg Phe Leu Asn Pro Asn Thr Leu Glu Arg 
        195                 200                 205             


Leu Thr Tyr His Gln Leu Leu Glu Arg Cys Val Arg Ala Pro Gly Ser 
    210                 215                 220                 


Gly Leu Ala Leu Leu Pro Leu Lys Ile Thr Phe Arg Ser Met Gly Gly 
225                 230                 235                 240 


Ala Val Ser Ala Ala Glu Leu Leu Glu Val Gly Ile Leu Asp Glu Gln 
                245                 250                 255     


Ala Val Gln Gly Leu Arg Glu Gly Arg Leu Ala Ala Val Asp Val Ser 
            260                 265                 270         


Ala Arg Ala Glu Val Arg Arg Tyr Leu Glu Gly Thr Gly Ser Val Ala 
        275                 280                 285             


Gly Val Val Leu Leu Pro Glu Gly His Lys Lys Ser Phe Phe Gln Ala 
    290                 295                 300                 


Ala Thr Glu His Leu Leu Pro Met Gly Thr Ala Leu Pro Leu Leu Glu 
305                 310                 315                 320 


Ala Gln Ala Ala Thr His Thr Leu Val Asp Pro Ile Thr Gly Gln Arg 
                325                 330                 335     


Leu Trp Val Asp Glu Ala Val Arg Ala Gly Leu Val Ser Pro Glu Leu 
            340                 345                 350         


His Glu Gln Leu Leu Val Ala Glu Gln Ala Val Thr Gly His His Asp 
        355                 360                 365             


Pro Phe Ser Gly Ser Gln Ile Pro Leu Phe Gln Ala Met Lys Lys Gly 
    370                 375                 380                 


Leu Val Asp Arg Pro Leu Ala Leu Arg Leu Leu Asp Ala Gln Leu Ala 
385                 390                 395                 400 


Thr Gly Gly Leu Val Cys Pro Ala Arg Arg Leu Arg Leu Pro Leu Glu 
                405                 410                 415     


Ala Ala Leu Arg Cys Gly Cys Leu Asp Glu Asp Thr Gln Arg Gln Leu 
            420                 425                 430         


Ser Gln Ala Gly Ser Phe Ser Asp Gly Thr His Gly Gly Leu Arg Tyr 
        435                 440                 445             


Glu Gln Leu Leu Ala Leu Cys Val Thr Asp Pro Glu Thr Gly Leu Ala 
    450                 455                 460                 


Phe Leu Pro Leu Ser Gly Gly Pro Arg Gly Gly Glu Pro Gln Gly Pro 
465                 470                 475                 480 


Pro Phe Ile Lys Tyr Ser Thr Arg Gln Ala Leu Ser Thr Ala Thr Ala 
                485                 490                 495     


Thr Val Ser Val Gly Lys Phe Arg Gly Arg Pro Val Ser Leu Trp Glu 
            500                 505                 510         


Leu Leu Phe Ser Glu Ala Ile Ser Ser Glu Gln Arg Ala Met Leu Ala 
        515                 520                 525             


Gln Gln Tyr Gln Glu Gly Thr Leu Ser Val Glu Lys Leu Ala Ala Glu 
    530                 535                 540                 


Leu Ser Ala Thr Leu Glu Gln Ala Ala Ala Thr Ala Arg Val Thr Phe 
545                 550                 555                 560 


Ser Gly Leu Arg Asp Thr Val Thr Pro Gly Glu Leu Leu Lys Ala Glu 
                565                 570                 575     


Ile Ile Asp Gln Asp Leu Tyr Glu Arg Leu Glu His Gly Gln Ala Thr 
            580                 585                 590         


Ala Lys Asp Val Gly Ser Leu Ala Ser Ala Gln Arg Tyr Leu Gln Gly 
        595                 600                 605             


Thr Gly Cys Ile Ala Gly Leu Leu Leu Pro Gly Ser Gln Glu Arg Leu 
    610                 615                 620                 


Ser Ile Tyr Glu Ala Arg Cys Lys Gly Leu Leu Arg Pro Gly Thr Ala 
625                 630                 635                 640 


Leu Ile Leu Leu Glu Ala Gln Ala Ala Thr Gly Phe Ile Ile Asp Pro 
                645                 650                 655     


Lys Ala Asn Lys Gly His Ser Val Glu Glu Ala Leu Arg Ala Ala Val 
            660                 665                 670         


Ile Gly Pro Asp Val Phe Ala Lys Leu Leu Ser Ala Glu Arg Ala Val 
        675                 680                 685             


Thr Gly Tyr Thr Asp Pro Tyr Thr Gly Gln Gln Ile Ser Leu Phe Gln 
    690                 695                 700                 


Ala Met Gln Lys Gly Leu Ile Val Arg Glu His Gly Ile Arg Leu Leu 
705                 710                 715                 720 


Glu Ala Gln Ile Ala Thr Gly Gly Val Ile Asp Pro Val His Ser His 
                725                 730                 735     


Arg Val Pro Val Asp Val Ala Tyr Arg Arg Gly Tyr Phe Asp Gln Met 
            740                 745                 750         


Leu Asn Leu Ile Leu Leu Asp Pro Ser Asp Asp Thr Lys Gly Phe Phe 
        755                 760                 765             


Asp Pro Asn Thr His Glu Asn Leu Thr Tyr Leu Gln Leu Leu Glu Arg 
    770                 775                 780                 


Cys Val Arg Asp Pro Glu Thr Gly Leu Tyr Leu Leu Pro Leu Ser Ser 
785                 790                 795                 800 


Thr Gln Ser Pro Leu Val Asp Ser Ala Thr Gln Gln Ala Phe Gln Asn 
                805                 810                 815     


Leu Leu Leu Ser Val Lys Tyr Gly Arg Phe Gln Gly Gln Arg Val Ser 
            820                 825                 830         


Ala Trp Glu Leu Ile Asn Ser Glu Tyr Phe Ser Glu Gly Arg Arg Arg 
        835                 840                 845             


Gln Leu Leu Arg Arg Tyr Arg Gln Arg Glu Val Thr Leu Gly Gln Val 
    850                 855                 860                 


Ala Lys Leu Leu Glu Ala Glu Thr Gln Arg Gln Ala Asp Ile Met Leu 
865                 870                 875                 880 


Pro Ala Leu Arg Ser Arg Val Thr Val His Gln Leu Leu Glu Ala Gly 
                885                 890                 895     


Ile Ile Asp Gln Gln Leu Leu Asp Gln Val Leu Ala Gly Thr Ile Ser 
            900                 905                 910         


Pro Glu Ala Leu Leu Leu Met Asp Gly Val Arg Arg Tyr Leu Cys Gly 
        915                 920                 925             


Leu Gly Ala Val Gly Gly Val Arg Leu Leu Pro Ser Gly Gln Arg Leu 
    930                 935                 940                 


Ser Leu Tyr Gln Ala Met Arg Gln Lys Leu Leu Gly Pro Arg Val Ala 
945                 950                 955                 960 


Leu Ala Leu Leu Glu Ala Gln Ala Ala Thr Gly Thr Ile Met Asp Pro 
                965                 970                 975     


His Ser Pro Glu Ser Leu Ser Val Asp Glu Ala Val Arg Arg Gly Val 
            980                 985                 990         


Val Gly Pro Glu Leu Tyr Gly Arg  Leu Lys Arg Ala Glu  Gly Ala Ile 
        995                 1000                 1005             


Ala Gly  Phe Arg Asp Pro Phe  Ser Gly Lys Gln Val  Ser Val Phe 
    1010                 1015                 1020             


Gln Ala  Met Lys Lys Gly Leu  Ile Pro Trp Glu Gln  Ala Ala Arg 
    1025                 1030                 1035             


Leu Leu  Glu Ala Gln Val Ala  Thr Gly Gly Ile Ile  Asp Pro Thr 
    1040                 1045                 1050             


Ser His  His His Leu Pro Met  Pro Val Ala Ile Gln  Arg Gly Tyr 
    1055                 1060                 1065             


Val Asp  Gln Glu Met Glu Thr  Ala Leu Ser Ser Ser  Ser Glu Thr 
    1070                 1075                 1080             


Phe Pro  Thr Pro Asp Gly Gln  Gly Arg Thr Ser Tyr  Ala Gln Leu 
    1085                 1090                 1095             


Leu Glu  Glu Cys Pro Arg Asp  Glu Thr Ser Gly Leu  His Leu Leu 
    1100                 1105                 1110             


Pro Leu  Pro Glu Ser Ala Pro  Ala Leu Pro Thr Glu  Glu Gln Val 
    1115                 1120                 1125             


Gln Arg  Ser Leu Gln Ala Val  Pro Gly Ala Lys Asp  Gly Thr Ser 
    1130                 1135                 1140             


Leu Trp  Asp Leu Leu Ser Ser  Cys His Phe Thr Glu  Glu Gln Arg 
    1145                 1150                 1155             


Arg Gly  Leu Leu Glu Asp Val  Gln Glu Gly Arg Thr  Thr Val Pro 
    1160                 1165                 1170             


Gln Leu  Leu Ala Ser Val Gln  Arg Trp Val Gln Glu  Thr Lys Leu 
    1175                 1180                 1185             


Leu Ala  Gln Ala Arg Val Met  Val Pro Gly Pro Arg  Gly Glu Val 
    1190                 1195                 1200             


Pro Ala  Val Trp Leu Leu Asp  Ala Gly Ile Ile Thr  Gln Glu Thr 
    1205                 1210                 1215             


Leu Glu  Ala Leu Ala Gln Gly  Thr Gln Ser Pro Ala  Gln Val Ala 
    1220                 1225                 1230             


Glu Gln  Pro Ala Val Lys Ala  Cys Leu Trp Gly Thr  Gly Cys Val 
    1235                 1240                 1245             


Ala Gly  Val Leu Leu Gln Pro  Ser Gly Ala Lys Ala  Ser Ile Ala 
    1250                 1255                 1260             


Gln Ala  Val Arg Asp Gly Leu  Leu Pro Thr Gly Leu  Gly Gln Arg 
    1265                 1270                 1275             


Leu Leu  Glu Ala Gln Val Ala  Ser Gly Phe Leu Val  Asp Pro Leu 
    1280                 1285                 1290             


Asn Asn  Gln Arg Leu Ser Val  Glu Asp Ala Val Lys  Val Gly Leu 
    1295                 1300                 1305             


Val Gly  Arg Glu Leu Ser Glu  Gln Leu Gly Gln Ala  Glu Arg Ala 
    1310                 1315                 1320             


Ala Ala  Gly Tyr Pro Asp Pro  Tyr Ser Arg Ala Ser  Leu Ser Leu 
    1325                 1330                 1335             


Trp Gln  Ala Met Glu Lys Gly  Leu Val Pro Gln Asn  Glu Gly Leu 
    1340                 1345                 1350             


Pro Leu  Leu Gln Val Gln Leu  Ala Thr Gly Gly Val  Val Asp Pro 
    1355                 1360                 1365             


Val His  Gly Val His Leu Pro  Gln Ala Ala Ala Cys  Arg Leu Gly 
    1370                 1375                 1380             


Leu Leu  Asp Thr Gln Thr Ser  Gln Val Leu Thr Ala  Val Asp Lys 
    1385                 1390                 1395             


Asp Asn  Lys Phe Phe Phe Asp  Pro Ser Ala Arg Asp  Gln Val Thr 
    1400                 1405                 1410             


Tyr Gln  Gln Leu Arg Glu Arg  Cys Val Cys Asp Ser  Glu Thr Gly 
    1415                 1420                 1425             


Leu Leu  Leu Leu Pro Leu Pro  Ser Asp Thr Val Leu  Glu Val Asp 
    1430                 1435                 1440             


Asp His  Thr Ala Val Ala Leu  Arg Ala Met Lys Val  Pro Val Ser 
    1445                 1450                 1455             


Thr Gly  Arg Phe Lys Gly Cys  Ser Val Ser Leu Trp  Asp Leu Leu 
    1460                 1465                 1470             


Leu Ser  Glu Tyr Val Gly Ala  Asp Lys Arg Arg Glu  Leu Val Ala 
    1475                 1480                 1485             


Leu Cys  Arg Ser Gly Arg Ala  Ala Ala Leu Arg Gln  Val Val Ser 
    1490                 1495                 1500             


Ala Val  Thr Ala Leu Val Glu  Ala Ala Glu Arg Gln  Pro Leu Gln 
    1505                 1510                 1515             


Ala Thr  Phe Arg Gly Leu Arg  Lys Gln Val Ser Ala  Arg Asp Leu 
    1520                 1525                 1530             


Phe Arg  Ala Gln Leu Ile Ser  Arg Lys Thr Leu Asp  Glu Leu Ser 
    1535                 1540                 1545             


Gln Gly  Thr Thr Thr Val Lys  Glu Val Ala Glu Met  Asp Ser Val 
    1550                 1555                 1560             


Lys Arg  Ser Leu Glu Gly Gly  Asn Phe Ile Ala Gly  Val Leu Ile 
    1565                 1570                 1575             


Gln Gly  Thr Gln Glu Arg Met  Ser Ile Pro Glu Ala  Leu Arg Arg 
    1580                 1585                 1590             


His Ile  Leu Arg Pro Gly Thr  Ala Leu Val Leu Leu  Glu Ala Gln 
    1595                 1600                 1605             


Ala Ala  Thr Gly Phe Ile Ile  Asp Pro Ala Glu Asn  Arg Lys Leu 
    1610                 1615                 1620             


Thr Val  Glu Glu Ala Phe Lys  Ala Gly Met Phe Gly  Lys Glu Thr 
    1625                 1630                 1635             


Tyr Val  Lys Leu Leu Ser Ala  Glu Arg Ala Val Thr  Gly Tyr Thr 
    1640                 1645                 1650             


Asp Pro  Tyr Thr Gly Gln Gln  Ile Ser Leu Phe Gln  Ala Met Gln 
    1655                 1660                 1665             


Lys Asp  Leu Ile Val Arg Glu  His Gly Ile Arg Leu  Leu Glu Ala 
    1670                 1675                 1680             


Gln Ile  Ala Thr Gly Gly Ile  Ile Asp Pro Val His  Ser His Arg 
    1685                 1690                 1695             


Val Pro  Val Asp Val Ala Tyr  Arg Cys Gly Tyr Phe  Asp Glu Glu 
    1700                 1705                 1710             


Met Asn  Arg Ile Leu Ala Asp  Pro Ser Asp Asp Thr  Lys Gly Phe 
    1715                 1720                 1725             


Phe Asp  Pro Asn Thr His Glu  Asn Leu Thr Tyr Leu  Gln Leu Leu 
    1730                 1735                 1740             


Glu Arg  Cys Val Glu Asp Pro  Glu Thr Gly Leu Tyr  Leu Leu Gln 
    1745                 1750                 1755             


Ile Ile  Lys Lys Gly Glu Asn  Tyr Val Tyr Ile Asn  Glu Ala Thr 
    1760                 1765                 1770             


Arg His  Val Leu Gln Ser Arg  Thr Ala Lys Met Arg  Val Gly Arg 
    1775                 1780                 1785             


Phe Ala  Asp Gln Val Val Ser  Phe Trp Asp Leu Leu  Ser Ser Pro 
    1790                 1795                 1800             


Tyr Phe  Thr Glu Asp Arg Lys  Arg Glu Leu Ile Gln  Glu Tyr Gly 
    1805                 1810                 1815             


Ala Gln  Ser Gly Gly Leu Glu  Lys Leu Leu Glu Ile  Ile Thr Thr 
    1820                 1825                 1830             


Thr Ile  Glu Glu Thr Glu Thr  Gln Asn Gln Gly Ile  Lys Val Ala 
    1835                 1840                 1845             


Ala Ile  Arg Gly Glu Val Thr  Ala Ala Asp Leu Phe  Asn Ser Arg 
    1850                 1855                 1860             


Val Ile  Asp Gln Lys Thr Leu  His Thr Leu Arg Val  Gly Arg Thr 
    1865                 1870                 1875             


Gly Gly  Gln Ala Leu Ser Thr  Leu Glu Cys Val Lys  Pro Tyr Leu 
    1880                 1885                 1890             


Glu Gly  Ser Asp Cys Ile Ala  Gly Val Thr Val Pro  Ser Thr Arg 
    1895                 1900                 1905             


Glu Val  Met Ser Leu His Glu  Ala Ser Arg Lys Glu  Leu Ile Pro 
    1910                 1915                 1920             


Ala Ala  Phe Ala Thr Trp Leu  Leu Glu Ala Gln Ala  Ala Thr Gly 
    1925                 1930                 1935             


Phe Leu  Leu Asp Pro Cys Thr  Arg Gln Lys Leu Ser  Val Asp Glu 
    1940                 1945                 1950             


Ala Val  Asp Val Gly Leu Val  Asn Glu Glu Leu Arg  Glu Arg Leu 
    1955                 1960                 1965             


Leu Lys  Ala Glu Arg Ala Ala  Thr Gly Tyr Arg Asp  Pro Ala Thr 
    1970                 1975                 1980             


Gly Asp  Thr Ile Pro Leu Phe  Gln Ala Met Gln Lys  Gln Leu Ile 
    1985                 1990                 1995             


Glu Lys  Ala Glu Ala Leu Arg  Leu Leu Glu Val Gln  Val Ala Thr 
    2000                 2005                 2010             


Gly Gly  Val Ile Asp Pro Gln  His His His Arg Leu  Pro Leu Glu 
    2015                 2020                 2025             


Thr Ala  Tyr Arg Arg Gly Cys  Leu His Lys Asp Ile  Tyr Ala Leu 
    2030                 2035                 2040             


Ile Ser  Asp Gln Lys His Met  Arg Lys Arg Phe Val  Asp Pro Asn 
    2045                 2050                 2055             


Thr Gln  Glu Lys Val Ser Tyr  Arg Glu Leu Gln Glu  Arg Cys Arg 
    2060                 2065                 2070             


Pro Gln  Glu Asp Thr Gly Trp  Val Leu Phe Pro Val  Asn Lys Ala 
    2075                 2080                 2085             


Ala Arg  Asp Ser Glu His Ile  Asp Asp Glu Thr Arg  Arg Ala Leu 
    2090                 2095                 2100             


Glu Ala  Glu Gln Val Glu Ile  Thr Val Gly Arg Phe  Arg Gly Gln 
    2105                 2110                 2115             


Lys Pro  Thr Leu Trp Ala Leu  Leu Asn Ser Glu Tyr  Val Thr Glu 
    2120                 2125                 2130             


Glu Lys  Lys Leu Gln Leu Val  Arg Met Tyr Arg Thr  His Thr Arg 
    2135                 2140                 2145             


Arg Ala  Leu Gln Thr Val Ala  Gln Leu Ile Leu Glu  Leu Ile Glu 
    2150                 2155                 2160             


Lys Gln  Glu Thr Ser Asn Lys  His Leu Trp Phe Gln  Gly Ile Arg 
    2165                 2170                 2175             


Arg Gln  Ile Thr Ala Ser Glu  Leu Leu Ser Ser Ala  Ile Ile Thr 
    2180                 2185                 2190             


Glu Glu  Met Leu Gln Asp Leu  Glu Thr Gly Arg Ser  Thr Thr Gln 
    2195                 2200                 2205             


Glu Leu  Met Glu Asp Asp Arg  Val Lys Arg Tyr Leu  Glu Gly Thr 
    2210                 2215                 2220             


Ser Cys  Ile Ala Gly Val Leu  Val Pro Ala Lys Asp  Gln Pro Gly 
    2225                 2230                 2235             


Arg Gln  Glu Lys Met Ser Ile  Tyr Gln Ala Met Trp  Lys Gly Val 
    2240                 2245                 2250             


Leu Arg  Pro Gly Thr Ala Leu  Val Leu Leu Glu Ala  Gln Ala Ala 
    2255                 2260                 2265             


Thr Gly  Phe Val Ile Asp Pro  Val Arg Asn Leu Arg  Leu Ser Val 
    2270                 2275                 2280             


Glu Glu  Pro Val Pro Ala Gly  Val Val Gly Ser Glu  Ile Gln Glu 
    2285                 2290                 2295             


Lys Leu  Leu Ser Ala Glu Arg  Ala Val Thr Gly Tyr  Thr Asp Pro 
    2300                 2305                 2310             


Tyr Thr  Gly Gln Gln Ile Ser  Leu Phe Gln Ala Met  Gln Lys Asp 
    2315                 2320                 2325             


Leu Ile  Val Arg Glu His Gly  Ile Arg Leu Leu Glu  Ala Gln Ile 
    2330                 2335                 2340             


Ala Thr  Gly Gly Val Ile Asp  Pro Val His Ser His  Arg Val Pro 
    2345                 2350                 2355             


Val Asp  Val Ala Tyr Arg Arg  Gly Tyr Phe Asp Glu  Glu Met Asn 
    2360                 2365                 2370             


Arg Val  Leu Ala Asp Pro Ser  Asp Asp Thr Lys Gly  Phe Phe Asp 
    2375                 2380                 2385             


Pro Asn  Thr His Glu Asn Leu  Thr Tyr Val Gln Leu  Leu Arg Arg 
    2390                 2395                 2400             


Cys Val  Pro Asp Pro Asp Thr  Gly Leu Tyr Met Leu  Gln Leu Ala 
    2405                 2410                 2415             


Gly Arg  Gly Ser Ala Val His  Gln Leu Ser Glu Glu  Leu Arg Cys 
    2420                 2425                 2430             


Ala Leu  Arg Asp Ala Arg Val  Thr Pro Gly Ser Gly  Ala Leu Gln 
    2435                 2440                 2445             


Gly Gln  Ser Val Ser Val Trp  Glu Leu Leu Phe Tyr  Arg Glu Val 
    2450                 2455                 2460             


Ser Glu  Asp Arg Arg Gln Asp  Leu Leu Ser Arg Tyr  Arg Ala Gly 
    2465                 2470                 2475             


Thr Leu  Thr Val Glu Glu Leu  Gly Ala Thr Leu Thr  Ser Leu Leu 
    2480                 2485                 2490             


Ala Gln  Ala Gln Ala Gln Ala  Arg Ala Glu Ala Glu  Ala Gly Ser 
    2495                 2500                 2505             


Pro Arg  Pro Asp Pro Arg Glu  Ala Leu Arg Ala Ala  Thr Met Glu 
    2510                 2515                 2520             


Val Lys  Val Gly Arg Leu Arg  Gly Arg Ala Val Pro  Val Trp Asp 
    2525                 2530                 2535             


Val Leu  Ala Ser Gly Tyr Val  Ser Arg Ala Ala Arg  Glu Glu Leu 
    2540                 2545                 2550             


Leu Ala  Glu Phe Gly Ser Gly  Thr Leu Asp Leu Pro  Ala Leu Thr 
    2555                 2560                 2565             


Arg Arg  Leu Thr Ala Ile Ile  Glu Glu Ala Glu Glu  Ala Pro Gly 
    2570                 2575                 2580             


Ala Arg  Pro Gln Leu Gln Asp  Ala Arg Arg Gly Pro  Arg Glu Pro 
    2585                 2590                 2595             


Gly Pro  Ala Gly Arg Gly Asp  Gly Asp Ser Gly Arg  Ser Gln Arg 
    2600                 2605                 2610             


Glu Gly  Gln Gly Glu Gly Glu  Thr Gln Glu Ala Ala  Ala Ala Ala 
    2615                 2620                 2625             


Ala Ala  Ala Arg Arg Gln Glu  Gln Thr Leu Arg Asp  Ala Thr Met 
    2630                 2635                 2640             


Glu Val  Gln Arg Gly Gln Phe  Gln Gly Arg Pro Val  Ser Val Trp 
    2645                 2650                 2655             


Asp Val  Leu Phe Ser Ser Tyr  Leu Ser Glu Ala Arg  Arg Asp Glu 
    2660                 2665                 2670             


Leu Leu  Ala Gln His Ala Ala  Gly Ala Leu Gly Leu  Pro Asp Leu 
    2675                 2680                 2685             


Val Ala  Val Leu Thr Arg Val  Ile Glu Glu Thr Glu  Glu Arg Leu 
    2690                 2695                 2700             


Ser Lys  Val Ser Phe Arg Gly  Leu Arg Arg Gln Val  Ser Ala Ser 
    2705                 2710                 2715             


Glu Leu  His Thr Ser Gly Ile  Leu Gly Pro Glu Thr  Leu Arg Asp 
    2720                 2725                 2730             


Leu Ala  Gln Gly Thr Lys Thr  Leu Gln Glu Val Thr  Glu Met Asp 
    2735                 2740                 2745             


Ser Val  Lys Arg Tyr Leu Glu  Gly Thr Ser Cys Ile  Ala Gly Val 
    2750                 2755                 2760             


Leu Val  Pro Ala Lys Asp Gln  Pro Gly Arg Gln Glu  Lys Met Ser 
    2765                 2770                 2775             


Ile Tyr  Gln Ala Met Trp Lys  Gly Val Leu Arg Pro  Gly Thr Ala 
    2780                 2785                 2790             


Leu Val  Leu Leu Glu Ala Gln  Ala Ala Thr Gly Phe  Val Ile Asp 
    2795                 2800                 2805             


Pro Val  Arg Asn Leu Arg Leu  Ser Val Glu Glu Ala  Val Ala Ala 
    2810                 2815                 2820             


Gly Val  Val Gly Gly Glu Ile  Gln Glu Lys Leu Leu  Ser Ala Glu 
    2825                 2830                 2835             


Arg Ala  Val Thr Gly Tyr Thr  Asp Pro Tyr Thr Gly  Gln Gln Ile 
    2840                 2845                 2850             


Ser Leu  Phe Gln Ala Met Gln  Lys Asp Leu Ile Val  Arg Glu His 
    2855                 2860                 2865             


Gly Ile  Arg Leu Leu Glu Ala  Gln Ile Ala Thr Gly  Gly Val Ile 
    2870                 2875                 2880             


Asp Pro  Val His Ser His Arg  Val Pro Val Asp Val  Ala Tyr Arg 
    2885                 2890                 2895             


Arg Gly  Tyr Phe Asp Glu Glu  Met Asn Arg Val Leu  Ala Asp Pro 
    2900                 2905                 2910             


Ser Asp  Asp Thr Lys Gly Phe  Phe Asp Pro Asn Thr  His Glu Asn 
    2915                 2920                 2925             


Leu Thr  Tyr Val Gln Leu Leu  Arg Arg Cys Val Pro  Asp Pro Asp 
    2930                 2935                 2940             


Thr Gly  Leu Tyr Met Leu Gln  Leu Ala Gly Arg Gly  Ser Ala Val 
    2945                 2950                 2955             


His Gln  Leu Ser Glu Glu Leu  Arg Cys Ala Leu Arg  Asp Ala Arg 
    2960                 2965                 2970             


Val Thr  Pro Gly Ser Gly Ala  Leu Gln Gly Gln Ser  Val Ser Val 
    2975                 2980                 2985             


Trp Glu  Leu Leu Phe Tyr Arg  Glu Val Ser Glu Asp  Arg Arg Gln 
    2990                 2995                 3000             


Asp Leu  Leu Ser Arg Tyr Arg  Ala Gly Thr Leu Thr  Val Glu Glu 
    3005                 3010                 3015             


Leu Gly  Ala Thr Leu Thr Ser  Leu Leu Ala Gln Ala  Gln Ala Gln 
    3020                 3025                 3030             


Ala Arg  Ala Glu Ala Glu Ala  Gly Ser Pro Arg Pro  Asp Pro Arg 
    3035                 3040                 3045             


Glu Ala  Leu Arg Ala Ala Thr  Met Glu Val Lys Val  Gly Arg Leu 
    3050                 3055                 3060             


Arg Gly  Arg Ala Val Pro Val  Trp Asp Val Leu Ala  Ser Gly Tyr 
    3065                 3070                 3075             


Val Ser  Gly Ala Ala Arg Glu  Glu Leu Leu Ala Glu  Phe Gly Ser 
    3080                 3085                 3090             


Gly Thr  Leu Asp Leu Pro Ala  Leu Thr Arg Arg Leu  Thr Ala Ile 
    3095                 3100                 3105             


Ile Glu  Glu Ala Glu Glu Ala  Pro Gly Ala Arg Pro  Gln Leu Gln 
    3110                 3115                 3120             


Asp Ala  Trp Arg Gly Pro Arg  Glu Pro Gly Pro Ala  Gly Arg Gly 
    3125                 3130                 3135             


Asp Gly  Asp Ser Gly Arg Ser  Gln Arg Glu Gly Gln  Gly Glu Gly 
    3140                 3145                 3150             


Glu Thr  Gln Glu Ala Ala Ala  Ala Ala Ala Ala Ala  Arg Arg Gln 
    3155                 3160                 3165             


Glu Gln  Thr Leu Arg Asp Ala  Thr Met Glu Val Gln  Arg Gly Gln 
    3170                 3175                 3180             


Phe Gln  Gly Arg Pro Val Ser  Val Trp Asp Val Leu  Phe Ser Ser 
    3185                 3190                 3195             


Tyr Leu  Ser Glu Ala Arg Arg  Asp Glu Leu Leu Ala  Gln His Ala 
    3200                 3205                 3210             


Ala Gly  Ala Leu Gly Leu Pro  Asp Leu Val Ala Val  Leu Thr Arg 
    3215                 3220                 3225             


Val Ile  Glu Glu Thr Glu Glu  Arg Leu Ser Lys Val  Ser Phe Arg 
    3230                 3235                 3240             


Gly Leu  Arg Arg Gln Val Ser  Ala Ser Glu Leu His  Thr Ser Gly 
    3245                 3250                 3255             


Ile Leu  Gly Pro Glu Thr Leu  Arg Asp Leu Ala Gln  Gly Thr Lys 
    3260                 3265                 3270             


Thr Leu  Gln Glu Val Thr Glu  Met Asp Ser Val Lys  Arg Tyr Leu 
    3275                 3280                 3285             


Glu Gly  Thr Ser Cys Ile Ala  Gly Val Leu Val Pro  Ala Lys Asp 
    3290                 3295                 3300             


Gln Pro  Gly Arg Gln Glu Lys  Met Ser Ile Tyr Gln  Ala Met Trp 
    3305                 3310                 3315             


Lys Gly  Val Leu Arg Pro Gly  Thr Ala Leu Val Leu  Leu Glu Ala 
    3320                 3325                 3330             


Gln Ala  Ala Thr Gly Phe Val  Ile Asp Pro Val Arg  Asn Leu Arg 
    3335                 3340                 3345             


Leu Ser  Val Glu Glu Ala Val  Ala Ala Gly Val Val  Gly Gly Glu 
    3350                 3355                 3360             


Ile Gln  Glu Lys Leu Leu Ser  Ala Glu Arg Ala Val  Thr Gly Tyr 
    3365                 3370                 3375             


Thr Asp  Pro Tyr Thr Gly Gln  Gln Ile Ser Leu Phe  Gln Ala Met 
    3380                 3385                 3390             


Gln Lys  Asp Leu Ile Val Arg  Glu His Gly Ile Arg  Leu Leu Glu 
    3395                 3400                 3405             


Ala Gln  Ile Ala Thr Gly Gly  Val Ile Asp Pro Val  His Ser His 
    3410                 3415                 3420             


Arg Val  Pro Val Asp Val Ala  Tyr Arg Arg Gly Tyr  Phe Asp Glu 
    3425                 3430                 3435             


Glu Met  Asn Arg Val Leu Ala  Asp Pro Ser Asp Asp  Thr Lys Gly 
    3440                 3445                 3450             


Phe Phe  Asp Pro Asn Thr His  Glu Asn Leu Thr Tyr  Val Gln Leu 
    3455                 3460                 3465             


Leu Arg  Arg Cys Val Pro Asp  Pro Asp Thr Gly Leu  Tyr Met Leu 
    3470                 3475                 3480             


Gln Leu  Ala Gly Arg Gly Ser  Ala Val His Gln Leu  Ser Glu Glu 
    3485                 3490                 3495             


Leu Arg  Cys Ala Leu Arg Asp  Ala Arg Val Thr Pro  Gly Ser Gly 
    3500                 3505                 3510             


Ala Leu  Gln Gly Gln Ser Val  Ser Val Trp Glu Leu  Leu Phe Tyr 
    3515                 3520                 3525             


Arg Glu  Val Ser Glu Asp Arg  Arg Gln Asp Leu Leu  Ser Arg Tyr 
    3530                 3535                 3540             


Arg Ala  Gly Thr Leu Thr Val  Glu Glu Leu Gly Ala  Thr Leu Thr 
    3545                 3550                 3555             


Ser Leu  Leu Ala Gln Ala Gln  Ala Gln Ala Arg Ala  Glu Ala Glu 
    3560                 3565                 3570             


Ala Gly  Ser Pro Arg Pro Asp  Pro Arg Glu Ala Leu  Arg Ala Ala 
    3575                 3580                 3585             


Thr Met  Glu Val Lys Val Gly  Arg Leu Arg Gly Arg  Ala Val Pro 
    3590                 3595                 3600             


Val Trp  Asp Val Leu Ala Ser  Gly Tyr Val Ser Gly  Ala Ala Arg 
    3605                 3610                 3615             


Glu Glu  Leu Leu Ala Glu Phe  Gly Ser Gly Thr Leu  Asp Leu Pro 
    3620                 3625                 3630             


Ala Leu  Thr Arg Arg Leu Thr  Ala Ile Ile Glu Glu  Ala Glu Glu 
    3635                 3640                 3645             


Ala Pro  Gly Ala Arg Pro Gln  Leu Gln Asp Ala Trp  Arg Gly Pro 
    3650                 3655                 3660             


Arg Glu  Pro Gly Pro Ala Gly  Arg Gly Asp Gly Asp  Ser Gly Arg 
    3665                 3670                 3675             


Ser Gln  Arg Glu Gly Gln Gly  Glu Gly Glu Thr Gln  Glu Ala Ala 
    3680                 3685                 3690             


Ala Ala  Ala Ala Ala Ala Arg  Arg Gln Glu Gln Thr  Leu Arg Asp 
    3695                 3700                 3705             


Ala Thr  Met Glu Val Gln Arg  Gly Gln Phe Gln Gly  Arg Pro Val 
    3710                 3715                 3720             


Ser Val  Trp Asp Val Leu Phe  Ser Ser Tyr Leu Ser  Glu Ala Arg 
    3725                 3730                 3735             


Arg Asp  Glu Leu Leu Ala Gln  His Ala Ala Gly Ala  Leu Gly Leu 
    3740                 3745                 3750             


Pro Asp  Leu Val Ala Val Leu  Thr Arg Val Ile Glu  Glu Thr Glu 
    3755                 3760                 3765             


Glu Arg  Leu Ser Lys Val Ser  Phe Arg Gly Leu Arg  Arg Gln Val 
    3770                 3775                 3780             


Ser Ala  Ser Glu Leu His Thr  Ser Gly Ile Leu Gly  Pro Glu Thr 
    3785                 3790                 3795             


Leu Arg  Asp Leu Ala Gln Gly  Thr Lys Thr Leu Gln  Glu Val Thr 
    3800                 3805                 3810             


Glu Met  Asp Ser Val Lys Arg  Tyr Leu Glu Gly Thr  Ser Cys Ile 
    3815                 3820                 3825             


Ala Gly  Val Leu Val Pro Ala  Lys Asp Gln Pro Gly  Arg Gln Glu 
    3830                 3835                 3840             


Lys Met  Ser Ile Tyr Gln Ala  Met Trp Lys Gly Val  Leu Arg Pro 
    3845                 3850                 3855             


Gly Thr  Ala Leu Val Leu Leu  Glu Ala Gln Ala Ala  Thr Gly Phe 
    3860                 3865                 3870             


Val Ile  Asp Pro Val Arg Asn  Leu Arg Leu Ser Val  Glu Glu Ala 
    3875                 3880                 3885             


Val Ala  Ala Gly Val Val Gly  Gly Glu Ile Gln Glu  Lys Leu Leu 
    3890                 3895                 3900             


Ser Ala  Glu Arg Ala Val Thr  Gly Tyr Thr Asp Pro  Tyr Thr Gly 
    3905                 3910                 3915             


Gln Gln  Ile Ser Leu Phe Gln  Ala Met Gln Lys Asp  Leu Ile Val 
    3920                 3925                 3930             


Arg Glu  His Gly Ile Arg Leu  Leu Glu Ala Gln Ile  Ala Thr Gly 
    3935                 3940                 3945             


Gly Val  Ile Asp Pro Val His  Ser His Arg Val Pro  Val Asp Val 
    3950                 3955                 3960             


Ala Tyr  Arg Arg Gly Tyr Phe  Asp Glu Glu Met Asn  Arg Val Leu 
    3965                 3970                 3975             


Ala Asp  Pro Ser Asp Asp Thr  Lys Gly Phe Phe Asp  Pro Asn Thr 
    3980                 3985                 3990             


His Glu  Asn Leu Thr Tyr Val  Gln Leu Leu Arg Arg  Cys Val Pro 
    3995                 4000                 4005             


Asp Pro  Asp Thr Gly Leu Tyr  Met Leu Gln Leu Ala  Gly Arg Gly 
    4010                 4015                 4020             


Ser Ala  Val His Gln Leu Ser  Glu Glu Leu Arg Cys  Ala Leu Arg 
    4025                 4030                 4035             


Asp Ala  Arg Val Thr Pro Gly  Ser Gly Ala Leu Gln  Gly Gln Ser 
    4040                 4045                 4050             


Val Ser  Val Trp Glu Leu Leu  Phe Tyr Arg Glu Val  Ser Glu Asp 
    4055                 4060                 4065             


Arg Arg  Gln Asp Leu Leu Ser  Arg Tyr Arg Ala Ser  Thr Leu Thr 
    4070                 4075                 4080             


Val Glu  Glu Leu Gly Ala Thr  Leu Thr Ser Leu Leu  Ala Gln Ala 
    4085                 4090                 4095             


Gln Ala  Gln Ala Arg Ala Glu  Ala Glu Ala Gly Ser  Pro Arg Pro 
    4100                 4105                 4110             


Asp Pro  Arg Glu Ala Leu Arg  Ala Ala Thr Met Glu  Val Lys Val 
    4115                 4120                 4125             


Gly Arg  Leu Arg Gly Arg Ala  Val Pro Val Trp Asp  Val Leu Ala 
    4130                 4135                 4140             


Ser Gly  Tyr Val Ser Arg Ala  Ala Arg Glu Glu Leu  Leu Ala Glu 
    4145                 4150                 4155             


Phe Gly  Ser Gly Thr Leu Asp  Leu Pro Ala Leu Thr  Arg Arg Leu 
    4160                 4165                 4170             


Thr Ala  Ile Ile Glu Glu Ala  Glu Glu Ala Pro Gly  Ala Arg Pro 
    4175                 4180                 4185             


Gln Leu  Gln Asp Ala Trp Arg  Gly Pro Arg Glu Pro  Gly Pro Ala 
    4190                 4195                 4200             


Gly Arg  Gly Asp Gly Asp Ser  Gly Arg Ser Gln Arg  Glu Gly Gln 
    4205                 4210                 4215             


Gly Glu  Gly Glu Thr Gln Glu  Ala Ala Ala Ala Thr  Ala Ala Ala 
    4220                 4225                 4230             


Arg Arg  Gln Glu Gln Thr Leu  Arg Asp Ala Thr Met  Glu Val Gln 
    4235                 4240                 4245             


Arg Gly  Gln Phe Gln Gly Arg  Pro Val Ser Val Trp  Asp Val Leu 
    4250                 4255                 4260             


Phe Ser  Ser Tyr Leu Ser Glu  Ala Arg Arg Asp Glu  Leu Leu Ala 
    4265                 4270                 4275             


Gln His  Ala Ala Gly Ala Leu  Gly Leu Pro Asp Leu  Val Ala Val 
    4280                 4285                 4290             


Leu Thr  Arg Val Ile Glu Glu  Thr Glu Glu Arg Leu  Ser Lys Val 
    4295                 4300                 4305             


Ser Phe  Arg Gly Leu Arg Arg  Gln Val Ser Ala Ser  Glu Leu His 
    4310                 4315                 4320             


Thr Ser  Gly Ile Leu Gly Pro  Glu Thr Leu Arg Asp  Leu Ala Gln 
    4325                 4330                 4335             


Gly Thr  Lys Thr Leu Gln Glu  Val Thr Glu Met Asp  Ser Val Lys 
    4340                 4345                 4350             


Arg Tyr  Leu Glu Gly Thr Ser  Cys Ile Ala Gly Val  Leu Val Pro 
    4355                 4360                 4365             


Ala Lys  Asp Gln Pro Gly Arg  Gln Glu Lys Met Ser  Ile Tyr Gln 
    4370                 4375                 4380             


Ala Met  Trp Lys Gly Val Leu  Arg Pro Gly Thr Ala  Leu Val Leu 
    4385                 4390                 4395             


Leu Glu  Ala Gln Ala Ala Thr  Gly Phe Val Ile Asp  Pro Val Arg 
    4400                 4405                 4410             


Asn Leu  Arg Leu Ser Val Glu  Glu Ala Val Ala Ala  Gly Val Val 
    4415                 4420                 4425             


Gly Gly  Glu Ile Gln Glu Lys  Leu Leu Ser Ala Glu  Arg Ala Val 
    4430                 4435                 4440             


Thr Gly  Tyr Thr Asp Pro Tyr  Thr Gly Gln Gln Ile  Ser Leu Phe 
    4445                 4450                 4455             


Gln Ala  Met Gln Lys Asp Leu  Ile Val Arg Glu His  Gly Ile Arg 
    4460                 4465                 4470             


Leu Leu  Glu Ala Gln Ile Ala  Thr Gly Gly Val Ile  Asp Pro Val 
    4475                 4480                 4485             


His Ser  His Arg Val Pro Val  Asp Val Ala Tyr Arg  Arg Gly Tyr 
    4490                 4495                 4500             


Phe Asp  Glu Glu Met Asn Arg  Val Leu Ala Asp Pro  Ser Asp Asp 
    4505                 4510                 4515             


Thr Lys  Gly Phe Phe Asp Pro  Asn Thr His Glu Asn  Leu Thr Tyr 
    4520                 4525                 4530             


Val Gln  Leu Leu Arg Arg Cys  Val Pro Asp Pro Asp  Thr Gly Leu 
    4535                 4540                 4545             


Tyr Met  Leu Gln Leu Ala Gly  Arg Gly Ser Ala Val  His Gln Leu 
    4550                 4555                 4560             


Ser Glu  Glu Leu Arg Cys Ala  Leu Arg Asp Ala Arg  Val Thr Pro 
    4565                 4570                 4575             


Gly Ser  Gly Ala Leu Gln Gly  Gln Ser Val Ser Val  Trp Glu Leu 
    4580                 4585                 4590             


Leu Phe  Tyr Arg Glu Val Ser  Glu Asp Arg Arg Gln  Asp Leu Leu 
    4595                 4600                 4605             


Ser Arg  Tyr Arg Ala Gly Thr  Leu Thr Val Glu Glu  Leu Gly Ala 
    4610                 4615                 4620             


Thr Leu  Thr Ser Leu Leu Ala  Gln Ala Gln Ala Gln  Ala Arg Ala 
    4625                 4630                 4635             


Glu Ala  Glu Ala Gly Ser Pro  Arg Pro Asp Pro Arg  Glu Ala Leu 
    4640                 4645                 4650             


Arg Ala  Ala Thr Met Glu Val  Lys Val Gly Arg Leu  Arg Gly Arg 
    4655                 4660                 4665             


Ala Val  Pro Val Trp Asp Val  Leu Ala Ser Gly Tyr  Val Ser Gly 
    4670                 4675                 4680             


Ala Ala  Arg Glu Glu Leu Leu  Ala Glu Phe Gly Ser  Gly Thr Leu 
    4685                 4690                 4695             


Asp Leu  Pro Ala Leu Thr Arg  Arg Leu Thr Ala Ile  Ile Glu Glu 
    4700                 4705                 4710             


Ala Glu  Glu Ala Pro Gly Ala  Arg Pro Gln Leu Gln  Asp Ala Trp 
    4715                 4720                 4725             


Arg Gly  Pro Arg Glu Pro Gly  Pro Ala Gly Arg Gly  Asp Gly Asp 
    4730                 4735                 4740             


Ser Gly  Arg Ser Gln Arg Glu  Gly Gln Gly Glu Gly  Glu Thr Gln 
    4745                 4750                 4755             


Glu Ala  Ala Ala Ala Ala Ala  Ala Ala Arg Arg Gln  Glu Gln Thr 
    4760                 4765                 4770             


Leu Arg  Asp Ala Thr Met Glu  Val Gln Arg Gly Gln  Phe Gln Gly 
    4775                 4780                 4785             


Arg Pro  Val Ser Val Trp Asp  Val Leu Phe Ser Ser  Tyr Leu Ser 
    4790                 4795                 4800             


Glu Ala  Arg Arg Asp Glu Leu  Leu Ala Gln His Ala  Ala Gly Ala 
    4805                 4810                 4815             


Leu Gly  Leu Pro Asp Leu Val  Ala Val Leu Thr Arg  Val Ile Glu 
    4820                 4825                 4830             


Glu Thr  Glu Glu Arg Leu Ser  Lys Val Ser Phe Arg  Gly Leu Arg 
    4835                 4840                 4845             


Arg Gln  Val Ser Ala Ser Glu  Leu His Thr Ser Gly  Ile Leu Gly 
    4850                 4855                 4860             


Pro Glu  Thr Leu Arg Asp Leu  Ala Gln Gly Thr Lys  Thr Leu Gln 
    4865                 4870                 4875             


Glu Val  Thr Glu Met Asp Ser  Val Lys Arg Tyr Leu  Glu Gly Thr 
    4880                 4885                 4890             


Ser Cys  Ile Ala Gly Val Leu  Val Pro Ala Lys Asp  Gln Pro Gly 
    4895                 4900                 4905             


Arg Gln  Glu Lys Met Ser Ile  Tyr Gln Ala Met Trp  Lys Gly Val 
    4910                 4915                 4920             


Leu Arg  Pro Gly Thr Ala Leu  Val Leu Leu Glu Ala  Gln Ala Ala 
    4925                 4930                 4935             


Thr Gly  Phe Val Ile Asp Pro  Val Arg Asn Leu Arg  Leu Ser Val 
    4940                 4945                 4950             


Glu Glu  Ala Val Ala Ala Gly  Val Val Gly Gly Glu  Ile Gln Glu 
    4955                 4960                 4965             


Lys Leu  Leu Ser Ala Glu Arg  Ala Val Thr Gly Tyr  Thr Asp Pro 
    4970                 4975                 4980             


Tyr Thr  Gly Gln Gln Ile Ser  Leu Phe Gln Ala Met  Gln Lys Asp 
    4985                 4990                 4995             


Leu Ile  Val Arg Glu His Gly  Ile Arg Leu Leu Glu  Ala Gln Ile 
    5000                 5005                 5010             


Ala Thr  Gly Gly Val Ile Asp  Pro Val His Ser His  Arg Val Pro 
    5015                 5020                 5025             


Val Asp  Val Ala Tyr Arg Arg  Gly Tyr Phe Asp Glu  Glu Met Asn 
    5030                 5035                 5040             


Arg Val  Leu Ala Asp Pro Ser  Asp Asp Thr Lys Gly  Phe Phe Asp 
    5045                 5050                 5055             


Pro Asn  Thr His Glu Asn Leu  Thr Tyr Leu Gln Leu  Leu Gln Arg 
    5060                 5065                 5070             


Ala Thr  Leu Asp Pro Glu Thr  Gly Leu Leu Phe Leu  Ser Leu Ser 
    5075                 5080                 5085             


Leu Gln  
    5090 


<210>  5
<211>  515
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Glucose-6-phosphate 1-dehydrogenase  short isoform 1

<400>  5

Met Ala Glu Gln Val Ala Leu Ser Arg Thr Gln Val Cys Gly Ile Leu 
1               5                   10                  15      


Arg Glu Glu Leu Phe Gln Gly Asp Ala Phe His Gln Ser Asp Thr His 
            20                  25                  30          


Ile Phe Ile Ile Met Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Ile 
        35                  40                  45              


Tyr Pro Thr Ile Trp Trp Leu Phe Arg Asp Gly Leu Leu Pro Glu Asn 
    50                  55                  60                  


Thr Phe Ile Val Gly Tyr Ala Arg Ser Arg Leu Thr Val Ala Asp Ile 
65                  70                  75                  80  


Arg Lys Gln Ser Glu Pro Phe Phe Lys Ala Thr Pro Glu Glu Lys Leu 
                85                  90                  95      


Lys Leu Glu Asp Phe Phe Ala Arg Asn Ser Tyr Val Ala Gly Gln Tyr 
            100                 105                 110         


Asp Asp Ala Ala Ser Tyr Gln Arg Leu Asn Ser His Met Asn Ala Leu 
        115                 120                 125             


His Leu Gly Ser Gln Ala Asn Arg Leu Phe Tyr Leu Ala Leu Pro Pro 
    130                 135                 140                 


Thr Val Tyr Glu Ala Val Thr Lys Asn Ile His Glu Ser Cys Met Ser 
145                 150                 155                 160 


Gln Ile Gly Trp Asn Arg Ile Ile Val Glu Lys Pro Phe Gly Arg Asp 
                165                 170                 175     


Leu Gln Ser Ser Asp Arg Leu Ser Asn His Ile Ser Ser Leu Phe Arg 
            180                 185                 190         


Glu Asp Gln Ile Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Met Val 
        195                 200                 205             


Gln Asn Leu Met Val Leu Arg Phe Ala Asn Arg Ile Phe Gly Pro Ile 
    210                 215                 220                 


Trp Asn Arg Asp Asn Ile Ala Cys Val Ile Leu Thr Phe Lys Glu Pro 
225                 230                 235                 240 


Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Glu Phe Gly Ile Ile 
                245                 250                 255     


Arg Asp Val Met Gln Asn His Leu Leu Gln Met Leu Cys Leu Val Ala 
            260                 265                 270         


Met Glu Lys Pro Ala Ser Thr Asn Ser Asp Asp Val Arg Asp Glu Lys 
        275                 280                 285             


Val Lys Val Leu Lys Cys Ile Ser Glu Val Gln Ala Asn Asn Val Val 
    290                 295                 300                 


Leu Gly Gln Tyr Val Gly Asn Pro Asp Gly Glu Gly Glu Ala Thr Lys 
305                 310                 315                 320 


Gly Tyr Leu Asp Asp Pro Thr Val Pro Arg Gly Ser Thr Thr Ala Thr 
                325                 330                 335     


Phe Ala Ala Val Val Leu Tyr Val Glu Asn Glu Arg Trp Asp Gly Val 
            340                 345                 350         


Pro Phe Ile Leu Arg Cys Gly Lys Ala Leu Asn Glu Arg Lys Ala Glu 
        355                 360                 365             


Val Arg Leu Gln Phe His Asp Val Ala Gly Asp Ile Phe His Gln Gln 
    370                 375                 380                 


Cys Lys Arg Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Val 
385                 390                 395                 400 


Tyr Thr Lys Met Met Thr Lys Lys Pro Gly Met Phe Phe Asn Pro Glu 
                405                 410                 415     


Glu Ser Glu Leu Asp Leu Thr Tyr Gly Asn Arg Tyr Lys Asn Val Lys 
            420                 425                 430         


Leu Pro Asp Ala Tyr Glu Arg Leu Ile Leu Asp Val Phe Cys Gly Ser 
        435                 440                 445             


Gln Met His Phe Val Arg Ser Asp Glu Leu Arg Glu Ala Trp Arg Ile 
    450                 455                 460                 


Phe Thr Pro Leu Leu His Gln Ile Glu Leu Glu Lys Pro Lys Pro Ile 
465                 470                 475                 480 


Pro Tyr Ile Tyr Gly Ser Arg Gly Pro Thr Glu Ala Asp Glu Leu Met 
                485                 490                 495     


Lys Arg Val Gly Phe Gln Tyr Glu Gly Thr Tyr Lys Trp Val Asn Pro 
            500                 505                 510         


His Lys Leu 
        515 


<210>  6
<211>  561
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Glucose-6-phosphate 1-dehydrogenase  long isoform 2

<400>  6

Met Ala Glu Gln Val Ala Leu Ser Arg Thr Gln Val Cys Gly Ile Leu 
1               5                   10                  15      


Arg Glu Glu Leu Phe Gln Gly Asp Ala Phe His Gln Ser Asp Thr His 
            20                  25                  30          


Ile Phe Ile Ile Met Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Ile 
        35                  40                  45              


Tyr Pro Thr Ile Trp Trp Leu Phe Arg Asp Gly Leu Leu Pro Glu Asn 
    50                  55                  60                  


Thr Phe Ile Val Gly Tyr Ala Arg Ser Arg Leu Thr Val Ala Asp Ile 
65                  70                  75                  80  


Arg Lys Gln Ser Glu Pro Phe Phe Lys Ala Thr Pro Glu Glu Lys Leu 
                85                  90                  95      


Lys Leu Glu Asp Phe Phe Ala Arg Asn Ser Tyr Val Ala Gly Gln Tyr 
            100                 105                 110         


Asp Asp Ala Ala Ser Tyr Gln Arg Leu Asn Ser His Met Asn Ala Leu 
        115                 120                 125             


His Leu Gly Ser Gln Ala Asn Arg Leu Phe Tyr Leu Ala Leu Pro Pro 
    130                 135                 140                 


Thr Val Tyr Glu Ala Val Thr Lys Asn Ile His Glu Ser Cys Met Ser 
145                 150                 155                 160 


Gln Ile Gly Trp Asn Arg Ile Ile Val Glu Lys Pro Phe Gly Arg Asp 
                165                 170                 175     


Leu Gln Ser Ser Asp Arg Leu Ser Asn His Ile Ser Ser Leu Phe Arg 
            180                 185                 190         


Glu Asp Gln Ile Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Met Val 
        195                 200                 205             


Gln Asn Leu Met Val Leu Arg Phe Ala Asn Arg Ile Phe Gly Pro Ile 
    210                 215                 220                 


Trp Asn Arg Asp Asn Ile Ala Cys Val Ile Leu Thr Phe Lys Glu Pro 
225                 230                 235                 240 


Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Glu Phe Gly Ile Ile 
                245                 250                 255     


Arg Gly Pro Gly Arg Gln Gly Gly Ser Gly Ser Glu Ser Cys Ser Leu 
            260                 265                 270         


Ser Leu Gly Ser Leu Val Trp Gly Pro His Ala Leu Glu Pro Gly Glu 
        275                 280                 285             


Gln Gly Gly Glu Leu Arg Arg Ala Leu Ala Ser Ser Val Pro Arg Asp 
    290                 295                 300                 


Val Met Gln Asn His Leu Leu Gln Met Leu Cys Leu Val Ala Met Glu 
305                 310                 315                 320 


Lys Pro Ala Ser Thr Asn Ser Asp Asp Val Arg Asp Glu Lys Val Lys 
                325                 330                 335     


Val Leu Lys Cys Ile Ser Glu Val Gln Ala Asn Asn Val Val Leu Gly 
            340                 345                 350         


Gln Tyr Val Gly Asn Pro Asp Gly Glu Gly Glu Ala Thr Lys Gly Tyr 
        355                 360                 365             


Leu Asp Asp Pro Thr Val Pro Arg Gly Ser Thr Thr Ala Thr Phe Ala 
    370                 375                 380                 


Ala Val Val Leu Tyr Val Glu Asn Glu Arg Trp Asp Gly Val Pro Phe 
385                 390                 395                 400 


Ile Leu Arg Cys Gly Lys Ala Leu Asn Glu Arg Lys Ala Glu Val Arg 
                405                 410                 415     


Leu Gln Phe His Asp Val Ala Gly Asp Ile Phe His Gln Gln Cys Lys 
            420                 425                 430         


Arg Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Val Tyr Thr 
        435                 440                 445             


Lys Met Met Thr Lys Lys Pro Gly Met Phe Phe Asn Pro Glu Glu Ser 
    450                 455                 460                 


Glu Leu Asp Leu Thr Tyr Gly Asn Arg Tyr Lys Asn Val Lys Leu Pro 
465                 470                 475                 480 


Asp Ala Tyr Glu Arg Leu Ile Leu Asp Val Phe Cys Gly Ser Gln Met 
                485                 490                 495     


His Phe Val Arg Ser Asp Glu Leu Arg Glu Ala Trp Arg Ile Phe Thr 
            500                 505                 510         


Pro Leu Leu His Gln Ile Glu Leu Glu Lys Pro Lys Pro Ile Pro Tyr 
        515                 520                 525             


Ile Tyr Gly Ser Arg Gly Pro Thr Glu Ala Asp Glu Leu Met Lys Arg 
    530                 535                 540                 


Val Gly Phe Gln Tyr Glu Gly Thr Tyr Lys Trp Val Asn Pro His Lys 
545                 550                 555                 560 


Leu 
    


<210>  7
<211>  545
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Glucose-6-phosphate 1-dehydrogenase  short isoform 3

<400>  7

Met Gly Arg Arg Gly Ser Ala Pro Gly Asn Gly Arg Thr Leu Arg Gly 
1               5                   10                  15      


Cys Glu Arg Gly Gly Arg Arg Arg Arg Ser Ala Asp Ser Val Met Ala 
            20                  25                  30          


Glu Gln Val Ala Leu Ser Arg Thr Gln Val Cys Gly Ile Leu Arg Glu 
        35                  40                  45              


Glu Leu Phe Gln Gly Asp Ala Phe His Gln Ser Asp Thr His Ile Phe 
    50                  55                  60                  


Ile Ile Met Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Ile Tyr Pro 
65                  70                  75                  80  


Thr Ile Trp Trp Leu Phe Arg Asp Gly Leu Leu Pro Glu Asn Thr Phe 
                85                  90                  95      


Ile Val Gly Tyr Ala Arg Ser Arg Leu Thr Val Ala Asp Ile Arg Lys 
            100                 105                 110         


Gln Ser Glu Pro Phe Phe Lys Ala Thr Pro Glu Glu Lys Leu Lys Leu 
        115                 120                 125             


Glu Asp Phe Phe Ala Arg Asn Ser Tyr Val Ala Gly Gln Tyr Asp Asp 
    130                 135                 140                 


Ala Ala Ser Tyr Gln Arg Leu Asn Ser His Met Asn Ala Leu His Leu 
145                 150                 155                 160 


Gly Ser Gln Ala Asn Arg Leu Phe Tyr Leu Ala Leu Pro Pro Thr Val 
                165                 170                 175     


Tyr Glu Ala Val Thr Lys Asn Ile His Glu Ser Cys Met Ser Gln Ile 
            180                 185                 190         


Gly Trp Asn Arg Ile Ile Val Glu Lys Pro Phe Gly Arg Asp Leu Gln 
        195                 200                 205             


Ser Ser Asp Arg Leu Ser Asn His Ile Ser Ser Leu Phe Arg Glu Asp 
    210                 215                 220                 


Gln Ile Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Met Val Gln Asn 
225                 230                 235                 240 


Leu Met Val Leu Arg Phe Ala Asn Arg Ile Phe Gly Pro Ile Trp Asn 
                245                 250                 255     


Arg Asp Asn Ile Ala Cys Val Ile Leu Thr Phe Lys Glu Pro Phe Gly 
            260                 265                 270         


Thr Glu Gly Arg Gly Gly Tyr Phe Asp Glu Phe Gly Ile Ile Arg Asp 
        275                 280                 285             


Val Met Gln Asn His Leu Leu Gln Met Leu Cys Leu Val Ala Met Glu 
    290                 295                 300                 


Lys Pro Ala Ser Thr Asn Ser Asp Asp Val Arg Asp Glu Lys Val Lys 
305                 310                 315                 320 


Val Leu Lys Cys Ile Ser Glu Val Gln Ala Asn Asn Val Val Leu Gly 
                325                 330                 335     


Gln Tyr Val Gly Asn Pro Asp Gly Glu Gly Glu Ala Thr Lys Gly Tyr 
            340                 345                 350         


Leu Asp Asp Pro Thr Val Pro Arg Gly Ser Thr Thr Ala Thr Phe Ala 
        355                 360                 365             


Ala Val Val Leu Tyr Val Glu Asn Glu Arg Trp Asp Gly Val Pro Phe 
    370                 375                 380                 


Ile Leu Arg Cys Gly Lys Ala Leu Asn Glu Arg Lys Ala Glu Val Arg 
385                 390                 395                 400 


Leu Gln Phe His Asp Val Ala Gly Asp Ile Phe His Gln Gln Cys Lys 
                405                 410                 415     


Arg Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Val Tyr Thr 
            420                 425                 430         


Lys Met Met Thr Lys Lys Pro Gly Met Phe Phe Asn Pro Glu Glu Ser 
        435                 440                 445             


Glu Leu Asp Leu Thr Tyr Gly Asn Arg Tyr Lys Asn Val Lys Leu Pro 
    450                 455                 460                 


Asp Ala Tyr Glu Arg Leu Ile Leu Asp Val Phe Cys Gly Ser Gln Met 
465                 470                 475                 480 


His Phe Val Arg Ser Asp Glu Leu Arg Glu Ala Trp Arg Ile Phe Thr 
                485                 490                 495     


Pro Leu Leu His Gln Ile Glu Leu Glu Lys Pro Lys Pro Ile Pro Tyr 
            500                 505                 510         


Ile Tyr Gly Ser Arg Gly Pro Thr Glu Ala Asp Glu Leu Met Lys Arg 
        515                 520                 525             


Val Gly Phe Gln Tyr Glu Gly Thr Tyr Lys Trp Val Asn Pro His Lys 
    530                 535                 540                 


Leu 
545 


<210>  8
<211>  452
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Isocitrate dehydrogenase [NADP]

<400>  8

Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
1               5                   10                  15      


Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
            20                  25                  30          


Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
        35                  40                  45              


Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
    50                  55                  60                  


Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
65                  70                  75                  80  


Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                85                  90                  95      


Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
            100                 105                 110         


Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
        115                 120                 125             


Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
    130                 135                 140                 


Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
145                 150                 155                 160 


Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                165                 170                 175     


Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
            180                 185                 190         


Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
        195                 200                 205             


Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
    210                 215                 220                 


Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
225                 230                 235                 240 


Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                245                 250                 255     


Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
            260                 265                 270         


His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
        275                 280                 285             


Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
    290                 295                 300                 


Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
305                 310                 315                 320 


Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                325                 330                 335     


Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
            340                 345                 350         


Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
        355                 360                 365             


Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
    370                 375                 380                 


Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
385                 390                 395                 400 


Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                405                 410                 415     


Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
            420                 425                 430         


Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
        435                 440                 445             


Leu Gly Arg Gln 
    450         


<210>  9
<211>  400
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Keratin type I cytoskeletal 19

<400>  9

Met Thr Ser Tyr Ser Tyr Arg Gln Ser Ser Ala Thr Ser Ser Phe Gly 
1               5                   10                  15      


Gly Leu Gly Gly Gly Ser Val Arg Phe Gly Pro Gly Val Ala Phe Arg 
            20                  25                  30          


Ala Pro Ser Ile His Gly Gly Ser Gly Gly Arg Gly Val Ser Val Ser 
        35                  40                  45              


Ser Ala Arg Phe Val Ser Ser Ser Ser Ser Gly Ala Tyr Gly Gly Gly 
    50                  55                  60                  


Tyr Gly Gly Val Leu Thr Ala Ser Asp Gly Leu Leu Ala Gly Asn Glu 
65                  70                  75                  80  


Lys Leu Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp 
                85                  90                  95      


Lys Val Arg Ala Leu Glu Ala Ala Asn Gly Glu Leu Glu Val Lys Ile 
            100                 105                 110         


Arg Asp Trp Tyr Gln Lys Gln Gly Pro Gly Pro Ser Arg Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Thr Thr Ile Gln Asp Leu Arg Asp Lys Ile Leu Gly Ala 
    130                 135                 140                 


Thr Ile Glu Asn Ser Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu 
145                 150                 155                 160 


Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln Ala Leu Arg 
                165                 170                 175     


Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val Leu Asp Glu 
            180                 185                 190         


Leu Thr Leu Ala Arg Thr Asp Leu Glu Met Gln Ile Glu Gly Leu Lys 
        195                 200                 205             


Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu Ile Ser Thr 
    210                 215                 220                 


Leu Arg Gly Gln Val Gly Gly Gln Val Ser Val Glu Val Asp Ser Ala 
225                 230                 235                 240 


Pro Gly Thr Asp Leu Ala Lys Ile Leu Ser Asp Met Arg Ser Gln Tyr 
                245                 250                 255     


Glu Val Met Ala Glu Gln Asn Arg Lys Asp Ala Glu Ala Trp Phe Thr 
            260                 265                 270         


Ser Arg Thr Glu Glu Leu Asn Arg Glu Val Ala Gly His Thr Glu Gln 
        275                 280                 285             


Leu Gln Met Ser Arg Ser Glu Val Thr Asp Leu Arg Arg Thr Leu Gln 
    290                 295                 300                 


Gly Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ala Leu 
305                 310                 315                 320 


Glu Asp Thr Leu Ala Glu Thr Glu Ala Arg Phe Gly Ala Gln Leu Ala 
                325                 330                 335     


His Ile Gln Ala Leu Ile Ser Gly Ile Glu Ala Gln Leu Gly Asp Val 
            340                 345                 350         


Arg Ala Asp Ser Glu Arg Gln Asn Gln Glu Tyr Gln Arg Leu Met Asp 
        355                 360                 365             


Ile Lys Ser Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu 
    370                 375                 380                 


Glu Gly Gln Glu Asp His Tyr Asn Asn Leu Ser Ala Ser Lys Val Leu 
385                 390                 395                 400 


<210>  10
<211>  483
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Keratin type I cytoskeletal 8 Isoform 1

<400>  10

Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly 
1               5                   10                  15      


Pro Arg Ala Phe Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg 
            20                  25                  30          


Ile Ser Ser Ser Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly 
        35                  40                  45              


Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr 
    50                  55                  60                  


Ala Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val 
65                  70                  75                  80  


Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys 
                85                  90                  95      


Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 
            100                 105                 110         


Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln 
        115                 120                 125             


Gln Lys Thr Ala Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile 
    130                 135                 140                 


Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys 
145                 150                 155                 160 


Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys 
                165                 170                 175     


Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu 
            180                 185                 190         


Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val 
        195                 200                 205             


Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu 
    210                 215                 220                 


Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser 
225                 230                 235                 240 


Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met 
                245                 250                 255     


Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn 
            260                 265                 270         


Arg Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu 
        275                 280                 285             


Leu Gln Ser Leu Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys 
    290                 295                 300                 


Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu 
305                 310                 315                 320 


Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala 
                325                 330                 335     


Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys 
            340                 345                 350         


Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala 
        355                 360                 365             


Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu 
    370                 375                 380                 


Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser 
385                 390                 395                 400 


Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr 
                405                 410                 415     


Ser Gly Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser 
            420                 425                 430         


Pro Gly Leu Ser Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly 
        435                 440                 445             


Ser Ser Ser Phe Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys 
    450                 455                 460                 


Lys Ile Glu Thr Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val 
465                 470                 475                 480 


Leu Pro Lys 
            


<210>  11
<211>  511
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Keratin type I cytoskeletal 8 Isoform 2

<400>  11

Met Asn Gly Val Ser Trp Ser Gln Asp Leu Gln Glu Gly Ile Ser Ala 
1               5                   10                  15      


Trp Phe Gly Pro Pro Ala Ser Thr Pro Ala Ser Thr Met Ser Ile Arg 
            20                  25                  30          


Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly Pro Arg Ala Phe 
        35                  40                  45              


Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg Ile Ser Ser Ser 
    50                  55                  60                  


Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly Gly Leu Gly Gly 
65                  70                  75                  80  


Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr Ala Val Thr Val 
                85                  90                  95      


Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val Asp Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys Thr Leu Asn Asn 
        115                 120                 125             


Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
    130                 135                 140                 


Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln Gln Lys Thr Ala 
145                 150                 155                 160 


Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile Asn Asn Leu Arg 
                165                 170                 175     


Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys Leu Glu Ala Glu 
            180                 185                 190         


Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu 
        195                 200                 205             


Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu Phe Val Leu Ile 
    210                 215                 220                 


Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val Glu Leu Glu Ser 
225                 230                 235                 240 


Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu Arg Gln Leu Tyr 
                245                 250                 255     


Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser Asp Thr Ser Val 
            260                 265                 270         


Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met Asp Ser Ile Ile 
        275                 280                 285             


Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn Arg Ser Arg Ala 
    290                 295                 300                 


Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu Leu Gln Ser Leu 
305                 310                 315                 320 


Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys Thr Glu Ile Ser 
                325                 330                 335     


Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu Ile Glu Gly Leu 
            340                 345                 350         


Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala Asp Ala Glu Gln 
        355                 360                 365             


Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu 
    370                 375                 380                 


Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala Arg Gln Leu Arg 
385                 390                 395                 400 


Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Ile Glu Ile 
                405                 410                 415     


Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Leu Glu Ser 
            420                 425                 430         


Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr Ser Gly Tyr Ala 
        435                 440                 445             


Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser Pro Gly Leu Ser 
    450                 455                 460                 


Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly Ser Ser Ser Phe 
465                 470                 475                 480 


Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys Lys Ile Glu Thr 
                485                 490                 495     


Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val Leu Pro Lys 
            500                 505                 510     


<210>  12
<211>  570
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Dihydropyrimidinase-related protein 3 Isoform 1

<400>  12

Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Arg Ile Thr Ser Asp Arg 
1               5                   10                  15      


Leu Leu Ile Lys Gly Gly Arg Ile Val Asn Asp Asp Gln Ser Phe Tyr 
            20                  25                  30          


Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Asp Asn 
        35                  40                  45              


Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Lys Met 
    50                  55                  60                  


Val Ile Pro Gly Gly Ile Asp Val His Thr His Phe Gln Met Pro Tyr 
65                  70                  75                  80  


Lys Gly Met Thr Thr Val Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 
                85                  90                  95      


Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 
            100                 105                 110         


Glu Ser Ser Leu Thr Glu Ala Tyr Glu Lys Trp Arg Glu Trp Ala Asp 
        115                 120                 125             


Gly Lys Ser Cys Cys Asp Tyr Ala Leu His Val Asp Ile Thr His Trp 
    130                 135                 140                 


Asn Asp Ser Val Lys Gln Glu Val Gln Asn Leu Ile Lys Asp Lys Gly 
145                 150                 155                 160 


Val Asn Ser Phe Met Val Tyr Met Ala Tyr Lys Asp Leu Tyr Gln Val 
                165                 170                 175     


Ser Asn Thr Glu Leu Tyr Glu Ile Phe Thr Cys Leu Gly Glu Leu Gly 
            180                 185                 190         


Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala Gln Glu 
        195                 200                 205             


Gln Thr Arg Met Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His Val 
    210                 215                 220                 


Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala Ile 
225                 230                 235                 240 


Thr Ile Ala Ser Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys Val Met 
                245                 250                 255     


Ser Lys Ser Ala Ala Asp Leu Ile Ser Gln Ala Arg Lys Lys Gly Asn 
            260                 265                 270         


Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Ile Asp Gly Thr 
        275                 280                 285             


His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 
    290                 295                 300                 


Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Ile Asn Ser Leu 
305                 310                 315                 320 


Leu Ala Ser Gly Asp Leu Gln Leu Ser Gly Ser Ala His Cys Thr Phe 
                325                 330                 335     


Ser Thr Ala Gln Lys Ala Ile Gly Lys Asp Asn Phe Thr Ala Ile Pro 
            340                 345                 350         


Glu Gly Thr Asn Gly Val Glu Glu Arg Met Ser Val Ile Trp Asp Lys 
        355                 360                 365             


Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 
    370                 375                 380                 


Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg 
385                 390                 395                 400 


Ile Ser Val Gly Ser Asp Ser Asp Leu Val Ile Trp Asp Pro Asp Ala 
                405                 410                 415     


Val Lys Ile Val Ser Ala Lys Asn His Gln Ser Ala Ala Glu Tyr Asn 
            420                 425                 430         


Ile Phe Glu Gly Met Glu Leu Arg Gly Ala Pro Leu Val Val Ile Cys 
        435                 440                 445             


Gln Gly Lys Ile Met Leu Glu Asp Gly Asn Leu His Val Thr Gln Gly 
    450                 455                 460                 


Ala Gly Arg Phe Ile Pro Cys Ser Pro Phe Ser Asp Tyr Val Tyr Lys 
465                 470                 475                 480 


Arg Ile Lys Ala Arg Arg Lys Met Ala Asp Leu His Ala Val Pro Arg 
                485                 490                 495     


Gly Met Tyr Asp Gly Pro Val Phe Asp Leu Thr Thr Thr Pro Lys Gly 
            500                 505                 510         


Gly Thr Pro Ala Gly Ser Ala Arg Gly Ser Pro Thr Arg Pro Asn Pro 
        515                 520                 525             


Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Thr Gln 
    530                 535                 540                 


Val Asp Glu Gly Val Arg Ser Ala Ser Lys Arg Ile Val Ala Pro Pro 
545                 550                 555                 560 


Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
                565                 570 


<210>  13
<211>  684
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Dihydropyrimidinase-related protein 3 Isoform LCRMP-4

<400>  13

Met Ala Ser Gly Arg Arg Gly Trp Asp Ser Ser His Glu Asp Asp Leu 
1               5                   10                  15      


Pro Val Tyr Leu Ala Arg Pro Gly Thr Thr Asp Gln Val Pro Arg Gln 
            20                  25                  30          


Lys Tyr Gly Gly Met Phe Cys Asn Val Glu Gly Ala Phe Glu Ser Lys 
        35                  40                  45              


Thr Leu Asp Phe Asp Ala Leu Ser Val Gly Gln Arg Gly Ala Lys Thr 
    50                  55                  60                  


Pro Arg Ser Gly Gln Gly Ser Asp Arg Gly Ser Gly Ser Arg Pro Gly 
65                  70                  75                  80  


Ile Glu Gly Asp Thr Pro Arg Arg Gly Gln Gly Arg Glu Glu Ser Arg 
                85                  90                  95      


Glu Pro Ala Pro Ala Ser Pro Ala Pro Ala Gly Val Glu Ile Arg Ser 
            100                 105                 110         


Ala Thr Gly Lys Glu Val Leu Gln Asn Leu Gly Pro Lys Asp Lys Ser 
        115                 120                 125             


Asp Arg Leu Leu Ile Lys Gly Gly Arg Ile Val Asn Asp Asp Gln Ser 
    130                 135                 140                 


Phe Tyr Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly 
145                 150                 155                 160 


Asp Asn Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly 
                165                 170                 175     


Lys Met Val Ile Pro Gly Gly Ile Asp Val His Thr His Phe Gln Met 
            180                 185                 190         


Pro Tyr Lys Gly Met Thr Thr Val Asp Asp Phe Phe Gln Gly Thr Lys 
        195                 200                 205             


Ala Ala Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro 
    210                 215                 220                 


Glu Pro Glu Ser Ser Leu Thr Glu Ala Tyr Glu Lys Trp Arg Glu Trp 
225                 230                 235                 240 


Ala Asp Gly Lys Ser Cys Cys Asp Tyr Ala Leu His Val Asp Ile Thr 
                245                 250                 255     


His Trp Asn Asp Ser Val Lys Gln Glu Val Gln Asn Leu Ile Lys Asp 
            260                 265                 270         


Lys Gly Val Asn Ser Phe Met Val Tyr Met Ala Tyr Lys Asp Leu Tyr 
        275                 280                 285             


Gln Val Ser Asn Thr Glu Leu Tyr Glu Ile Phe Thr Cys Leu Gly Glu 
    290                 295                 300                 


Leu Gly Ala Ile Ala Gln Val His Ala Glu Asn Gly Asp Ile Ile Ala 
305                 310                 315                 320 


Gln Glu Gln Thr Arg Met Leu Glu Met Gly Ile Thr Gly Pro Glu Gly 
                325                 330                 335     


His Val Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg 
            340                 345                 350         


Ala Ile Thr Ile Ala Ser Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys 
        355                 360                 365             


Val Met Ser Lys Ser Ala Ala Asp Leu Ile Ser Gln Ala Arg Lys Lys 
    370                 375                 380                 


Gly Asn Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Ile Asp 
385                 390                 395                 400 


Gly Thr His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val 
                405                 410                 415     


Thr Ser Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Ile Asn 
            420                 425                 430         


Ser Leu Leu Ala Ser Gly Asp Leu Gln Leu Ser Gly Ser Ala His Cys 
        435                 440                 445             


Thr Phe Ser Thr Ala Gln Lys Ala Ile Gly Lys Asp Asn Phe Thr Ala 
    450                 455                 460                 


Ile Pro Glu Gly Thr Asn Gly Val Glu Glu Arg Met Ser Val Ile Trp 
465                 470                 475                 480 


Asp Lys Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala 
                485                 490                 495     


Val Thr Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys 
            500                 505                 510         


Gly Arg Ile Ser Val Gly Ser Asp Ser Asp Leu Val Ile Trp Asp Pro 
        515                 520                 525             


Asp Ala Val Lys Ile Val Ser Ala Lys Asn His Gln Ser Ala Ala Glu 
    530                 535                 540                 


Tyr Asn Ile Phe Glu Gly Met Glu Leu Arg Gly Ala Pro Leu Val Val 
545                 550                 555                 560 


Ile Cys Gln Gly Lys Ile Met Leu Glu Asp Gly Asn Leu His Val Thr 
                565                 570                 575     


Gln Gly Ala Gly Arg Phe Ile Pro Cys Ser Pro Phe Ser Asp Tyr Val 
            580                 585                 590         


Tyr Lys Arg Ile Lys Ala Arg Arg Lys Met Ala Asp Leu His Ala Val 
        595                 600                 605             


Pro Arg Gly Met Tyr Asp Gly Pro Val Phe Asp Leu Thr Thr Thr Pro 
    610                 615                 620                 


Lys Gly Gly Thr Pro Ala Gly Ser Ala Arg Gly Ser Pro Thr Arg Pro 
625                 630                 635                 640 


Asn Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly 
                645                 650                 655     


Thr Gln Val Asp Glu Gly Val Arg Ser Ala Ser Lys Arg Ile Val Ala 
            660                 665                 670         


Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 
        675                 680                 


<210>  14
<211>  1170
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Thrombospondin-1

<400>  14

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  15
<211>  471
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Tryptophanyl-tRNA synthetase Isoform 1

<400>  15

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
        355                 360                 365             


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
    370                 375                 380                 


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
385                 390                 395                 400 


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
                405                 410                 415     


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
            420                 425                 430         


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
        435                 440                 445             


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
    450                 455                 460                 


Lys Leu Ser Phe Asp Phe Gln 
465                 470     


<210>  16
<211>  424
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Tryptophanyl-tRNA synthetase Isoform 2

<400>  16

Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro 
1               5                   10                  15      


Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu 
            20                  25                  30          


Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala 
        35                  40                  45              


Lys Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys 
    50                  55                  60                  


Ile Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg 
65                  70                  75                  80  


Pro His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met 
                85                  90                  95      


Asn Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr 
            100                 105                 110         


Thr Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile 
        115                 120                 125             


Pro Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu 
    130                 135                 140                 


Val Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr 
145                 150                 155                 160 


Leu Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile 
                165                 170                 175     


Ala Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp 
            180                 185                 190         


Tyr Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln 
        195                 200                 205             


Lys His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp 
    210                 215                 220                 


Ser Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro 
225                 230                 235                 240 


Ser Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile 
                245                 250                 255     


Gln Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met 
            260                 265                 270         


Thr Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu 
        275                 280                 285             


His Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser 
    290                 295                 300                 


Ala Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln 
305                 310                 315                 320 


Ile Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr 
                325                 330                 335     


Ile Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser 
            340                 345                 350         


Phe Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln 
        355                 360                 365             


Ile Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys 
    370                 375                 380                 


Lys Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala 
385                 390                 395                 400 


Arg Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro 
                405                 410                 415     


Arg Lys Leu Ser Phe Asp Phe Gln 
            420                 


<210>  17
<211>  626
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  SAM domain and HD domain-containing protein 1 Isoform 1

<400>  17

Met Gln Arg Ala Asp Ser Glu Gln Pro Ser Lys Arg Pro Arg Cys Asp 
1               5                   10                  15      


Asp Ser Pro Arg Thr Pro Ser Asn Thr Pro Ser Ala Glu Ala Asp Trp 
            20                  25                  30          


Ser Pro Gly Leu Glu Leu His Pro Asp Tyr Lys Thr Trp Gly Pro Glu 
        35                  40                  45              


Gln Val Cys Ser Phe Leu Arg Arg Gly Gly Phe Glu Glu Pro Val Leu 
    50                  55                  60                  


Leu Lys Asn Ile Arg Glu Asn Glu Ile Thr Gly Ala Leu Leu Pro Cys 
65                  70                  75                  80  


Leu Asp Glu Ser Arg Phe Glu Asn Leu Gly Val Ser Ser Leu Gly Glu 
                85                  90                  95      


Arg Lys Lys Leu Leu Ser Tyr Ile Gln Arg Leu Val Gln Ile His Val 
            100                 105                 110         


Asp Thr Met Lys Val Ile Asn Asp Pro Ile His Gly His Ile Glu Leu 
        115                 120                 125             


His Pro Leu Leu Val Arg Ile Ile Asp Thr Pro Gln Phe Gln Arg Leu 
    130                 135                 140                 


Arg Tyr Ile Lys Gln Leu Gly Gly Gly Tyr Tyr Val Phe Pro Gly Ala 
145                 150                 155                 160 


Ser His Asn Arg Phe Glu His Ser Leu Gly Val Gly Tyr Leu Ala Gly 
                165                 170                 175     


Cys Leu Val His Ala Leu Gly Glu Lys Gln Pro Glu Leu Gln Ile Ser 
            180                 185                 190         


Glu Arg Asp Val Leu Cys Val Gln Ile Ala Gly Leu Cys His Asp Leu 
        195                 200                 205             


Gly His Gly Pro Phe Ser His Met Phe Asp Gly Arg Phe Ile Pro Leu 
    210                 215                 220                 


Ala Arg Pro Glu Val Lys Trp Thr His Glu Gln Gly Ser Val Met Met 
225                 230                 235                 240 


Phe Glu His Leu Ile Asn Ser Asn Gly Ile Lys Pro Val Met Glu Gln 
                245                 250                 255     


Tyr Gly Leu Ile Pro Glu Glu Asp Ile Cys Phe Ile Lys Glu Gln Ile 
            260                 265                 270         


Val Gly Pro Leu Glu Ser Pro Val Glu Asp Ser Leu Trp Pro Tyr Lys 
        275                 280                 285             


Gly Arg Pro Glu Asn Lys Ser Phe Leu Tyr Glu Ile Val Ser Asn Lys 
    290                 295                 300                 


Arg Asn Gly Ile Asp Val Asp Lys Trp Asp Tyr Phe Ala Arg Asp Cys 
305                 310                 315                 320 


His His Leu Gly Ile Gln Asn Asn Phe Asp Tyr Lys Arg Phe Ile Lys 
                325                 330                 335     


Phe Ala Arg Val Cys Glu Val Asp Asn Glu Leu Arg Ile Cys Ala Arg 
            340                 345                 350         


Asp Lys Glu Val Gly Asn Leu Tyr Asp Met Phe His Thr Arg Asn Ser 
        355                 360                 365             


Leu His Arg Arg Ala Tyr Gln His Lys Val Gly Asn Ile Ile Asp Thr 
    370                 375                 380                 


Met Ile Thr Asp Ala Phe Leu Lys Ala Asp Asp Tyr Ile Glu Ile Thr 
385                 390                 395                 400 


Gly Ala Gly Gly Lys Lys Tyr Arg Ile Ser Thr Ala Ile Asp Asp Met 
                405                 410                 415     


Glu Ala Tyr Thr Lys Leu Thr Asp Asn Ile Phe Leu Glu Ile Leu Tyr 
            420                 425                 430         


Ser Thr Asp Pro Lys Leu Lys Asp Ala Arg Glu Ile Leu Lys Gln Ile 
        435                 440                 445             


Glu Tyr Arg Asn Leu Phe Lys Tyr Val Gly Glu Thr Gln Pro Thr Gly 
    450                 455                 460                 


Gln Ile Lys Ile Lys Arg Glu Asp Tyr Glu Ser Leu Pro Lys Glu Val 
465                 470                 475                 480 


Ala Ser Ala Lys Pro Lys Val Leu Leu Asp Val Lys Leu Lys Ala Glu 
                485                 490                 495     


Asp Phe Ile Val Asp Val Ile Asn Met Asp Tyr Gly Met Gln Glu Lys 
            500                 505                 510         


Asn Pro Ile Asp His Val Ser Phe Tyr Cys Lys Thr Ala Pro Asn Arg 
        515                 520                 525             


Ala Ile Arg Ile Thr Lys Asn Gln Val Ser Gln Leu Leu Pro Glu Lys 
    530                 535                 540                 


Phe Ala Glu Gln Leu Ile Arg Val Tyr Cys Lys Lys Val Asp Arg Lys 
545                 550                 555                 560 


Ser Leu Tyr Ala Ala Arg Gln Tyr Phe Val Gln Trp Cys Ala Asp Arg 
                565                 570                 575     


Asn Phe Thr Lys Pro Gln Asp Gly Asp Val Ile Ala Pro Leu Ile Thr 
            580                 585                 590         


Pro Gln Lys Lys Glu Trp Asn Asp Ser Thr Ser Val Gln Asn Pro Thr 
        595                 600                 605             


Arg Leu Arg Glu Ala Ser Lys Ser Arg Val Gln Leu Phe Lys Asp Asp 
    610                 615                 620                 


Pro Met 
625     


<210>  18
<211>  602
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  SAM domain and HD domain-containing protein 1 Isoform 2

<400>  18

Met Gln Arg Ala Asp Ser Glu Gln Pro Ser Lys Arg Pro Arg Cys Asp 
1               5                   10                  15      


Asp Ser Pro Arg Thr Pro Ser Asn Thr Pro Ser Ala Glu Ala Asp Trp 
            20                  25                  30          


Ser Pro Gly Leu Glu Leu His Pro Asp Tyr Lys Thr Trp Gly Pro Glu 
        35                  40                  45              


Gln Val Cys Ser Phe Leu Arg Arg Gly Gly Phe Glu Glu Pro Val Leu 
    50                  55                  60                  


Leu Lys Asn Ile Arg Glu Asn Glu Ile Thr Gly Ala Leu Leu Pro Cys 
65                  70                  75                  80  


Leu Asp Glu Ser Arg Phe Glu Asn Leu Gly Val Ser Ser Leu Gly Glu 
                85                  90                  95      


Arg Lys Lys Leu Leu Ser Tyr Ile Gln Arg Leu Val Gln Ile His Val 
            100                 105                 110         


Asp Thr Pro Gln Phe Gln Arg Leu Arg Tyr Ile Lys Gln Leu Gly Gly 
        115                 120                 125             


Gly Tyr Tyr Val Phe Pro Gly Ala Ser His Asn Arg Phe Glu His Ser 
    130                 135                 140                 


Leu Gly Val Gly Tyr Leu Ala Gly Cys Leu Val His Ala Leu Gly Glu 
145                 150                 155                 160 


Lys Gln Pro Glu Leu Gln Ile Ser Glu Arg Asp Val Leu Cys Val Gln 
                165                 170                 175     


Ile Ala Gly Leu Cys His Asp Leu Gly His Gly Pro Phe Ser His Met 
            180                 185                 190         


Phe Asp Gly Arg Phe Ile Pro Leu Ala Arg Pro Glu Val Lys Trp Thr 
        195                 200                 205             


His Glu Gln Gly Ser Val Met Met Phe Glu His Leu Ile Asn Ser Asn 
    210                 215                 220                 


Gly Ile Lys Pro Val Met Glu Gln Tyr Gly Leu Ile Pro Glu Glu Asp 
225                 230                 235                 240 


Ile Cys Phe Ile Lys Glu Gln Ile Val Gly Pro Leu Glu Ser Pro Val 
                245                 250                 255     


Glu Asp Ser Leu Trp Pro Tyr Lys Gly Arg Pro Glu Asn Lys Ser Phe 
            260                 265                 270         


Leu Tyr Glu Ile Val Ser Asn Lys Arg Asn Gly Ile Asp Val Asp Lys 
        275                 280                 285             


Trp Asp Tyr Phe Ala Arg Asp Cys His His Leu Gly Ile Gln Asn Asn 
    290                 295                 300                 


Phe Asp Tyr Lys Arg Phe Ile Lys Phe Ala Arg Val Cys Glu Val Asp 
305                 310                 315                 320 


Asn Glu Leu Arg Ile Cys Ala Arg Asp Lys Glu Val Gly Asn Leu Tyr 
                325                 330                 335     


Asp Met Phe His Thr Arg Asn Ser Leu His Arg Arg Ala Tyr Gln His 
            340                 345                 350         


Lys Val Gly Asn Ile Ile Asp Thr Met Ile Thr Asp Ala Phe Leu Lys 
        355                 360                 365             


Ala Asp Asp Tyr Ile Glu Ile Thr Gly Ala Gly Gly Lys Lys Tyr Arg 
    370                 375                 380                 


Ile Ser Thr Ala Ile Asp Asp Met Glu Ala Tyr Thr Lys Leu Thr Asp 
385                 390                 395                 400 


Asn Ile Phe Leu Glu Ile Leu Tyr Ser Thr Asp Pro Lys Leu Lys Asp 
                405                 410                 415     


Ala Arg Glu Ile Leu Lys Gln Ile Glu Tyr Arg Asn Leu Phe Lys Tyr 
            420                 425                 430         


Val Gly Glu Thr Gln Pro Thr Gly Gln Ile Lys Ile Lys Arg Glu Asp 
        435                 440                 445             


Tyr Glu Ser Leu Pro Lys Glu Val Ala Ser Ala Lys Pro Lys Val Leu 
    450                 455                 460                 


Leu Asp Val Lys Leu Lys Ala Glu Asp Phe Ile Val Asp Val Ile Asn 
465                 470                 475                 480 


Met Asp Tyr Gly Met Gln Glu Lys Asn Pro Ile Asp His Val Ser Phe 
                485                 490                 495     


Tyr Cys Lys Thr Ala Pro Asn Arg Ala Ile Arg Ile Thr Lys Asn Gln 
            500                 505                 510         


Val Ser Gln Leu Leu Pro Glu Lys Phe Ala Glu Gln Leu Ile Arg Val 
        515                 520                 525             


Tyr Cys Lys Lys Val Asp Arg Lys Ser Leu Tyr Ala Ala Arg Gln Tyr 
    530                 535                 540                 


Phe Val Gln Trp Cys Ala Asp Arg Asn Phe Thr Lys Pro Gln Asp Gly 
545                 550                 555                 560 


Asp Val Ile Ala Pro Leu Ile Thr Pro Gln Lys Lys Glu Trp Asn Asp 
                565                 570                 575     


Ser Thr Ser Val Gln Asn Pro Thr Arg Leu Arg Glu Ala Ser Lys Ser 
            580                 585                 590         


Arg Val Gln Leu Phe Lys Asp Asp Pro Met 
        595                 600         


<210>  19
<211>  102
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  10 kDa heat shock protein, mitochondrial

<400>  19

Met Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val 
1               5                   10                  15      


Leu Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met 
            20                  25                  30          


Leu Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala 
        35                  40                  45              


Val Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser 
    50                  55                  60                  


Val Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys 
65                  70                  75                  80  


Val Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile 
                85                  90                  95      


Leu Gly Lys Tyr Val Asp 
            100         


<210>  20
<211>  330
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Ig gamma-1 chain C region

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  21
<211>  917
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Hexokinase-1 Isoform 1

<400>  21

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
        35                  40                  45              


Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
65                  70                  75                  80  


Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                85                  90                  95      


Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
            100                 105                 110         


Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
        115                 120                 125             


His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
145                 150                 155                 160 


Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                165                 170                 175     


Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
            180                 185                 190         


Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
    210                 215                 220                 


Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
305                 310                 315                 320 


Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                325                 330                 335     


Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
            340                 345                 350         


Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
        355                 360                 365             


Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
385                 390                 395                 400 


Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                405                 410                 415     


Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
            420                 425                 430         


Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
465                 470                 475                 480 


Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                485                 490                 495     


Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
            500                 505                 510         


Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
            580                 585                 590         


Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
625                 630                 635                 640 


Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
    690                 695                 700                 


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala 
                725                 730                 735     


Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
        755                 760                 765             


Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
865                 870                 875                 880 


Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
            900                 905                 910         


Thr Glu Ala Ser Ser 
        915         


<210>  22
<211>  916
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Hexokinase-1 Isoform 2

<400>  22

Met Asp Cys Glu His Ser Leu Ser Leu Pro Cys Arg Gly Ala Glu Ala 
1               5                   10                  15      


Trp Glu Ile Gly Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser Asp 
            20                  25                  30          


Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys Asn 
        35                  40                  45              


Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu Pro 
    50                  55                  60                  


Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe Ile 
65                  70                  75                  80  


Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln Val 
                85                  90                  95      


Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr Asp 
            100                 105                 110         


Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp His 
        115                 120                 125             


Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys Asp 
    130                 135                 140                 


Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln Ser 
145                 150                 155                 160 


Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys Ala 
                165                 170                 175     


Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala Ile 
            180                 185                 190         


Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn Asp 
        195                 200                 205             


Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys Glu 
    210                 215                 220                 


Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu Glu 
225                 230                 235                 240 


Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys Ile 
                245                 250                 255     


Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp Ile 
            260                 265                 270         


Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro Gly 
        275                 280                 285             


Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu Leu 
    290                 295                 300                 


Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe Glu 
305                 310                 315                 320 


Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr Ser 
                325                 330                 335     


Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala Lys 
            340                 345                 350         


Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys Val 
        355                 360                 365             


Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn Leu 
    370                 375                 380                 


Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn Lys 
385                 390                 395                 400 


Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu Tyr 
                405                 410                 415     


Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg Arg 
            420                 425                 430         


Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly Ser 
        435                 440                 445             


Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala Glu 
    450                 455                 460                 


Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr Lys 
465                 470                 475                 480 


Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu Leu 
                485                 490                 495     


Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu Pro 
            500                 505                 510         


Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe Leu 
        515                 520                 525             


Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys Ile 
    530                 535                 540                 


Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr Ala 
545                 550                 555                 560 


Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His 
                565                 570                 575     


Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys Gly 
            580                 585                 590         


Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln Thr 
        595                 600                 605             


Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys Ala 
    610                 615                 620                 


Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala Ile 
625                 630                 635                 640 


Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn Asp 
                645                 650                 655     


Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys Glu 
            660                 665                 670         


Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu Glu 
        675                 680                 685             


Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys Ile 
    690                 695                 700                 


Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp Ile 
705                 710                 715                 720 


Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala Gly 
                725                 730                 735     


Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu Ile 
            740                 745                 750         


Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe Arg 
        755                 760                 765             


Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr Lys 
    770                 775                 780                 


Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg 
785                 790                 795                 800 


Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser Ile 
                805                 810                 815     


Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln Leu 
            820                 825                 830         


Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn Arg 
        835                 840                 845             


Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu Tyr 
    850                 855                 860                 


Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys Glu 
865                 870                 875                 880 


Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly Ser 
                885                 890                 895     


Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg Thr 
            900                 905                 910         


Glu Ala Ser Ser 
        915     


<210>  23
<211>  921
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Hexokinase-1 Isoform 3

<400>  23

Met Gly Gln Ile Cys Gln Arg Glu Ser Ala Thr Ala Ala Glu Lys Pro 
1               5                   10                  15      


Lys Leu His Leu Leu Ala Glu Ser Glu Ile Asp Lys Tyr Leu Tyr Ala 
            20                  25                  30          


Met Arg Leu Ser Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg 
        35                  40                  45              


Lys Glu Met Lys Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr 
    50                  55                  60                  


Val Lys Met Leu Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu 
65                  70                  75                  80  


Lys Gly Asp Phe Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile 
                85                  90                  95      


Leu Arg Val Gln Val Asn His Glu Lys Asn Gln Asn Val His Met Glu 
            100                 105                 110         


Ser Glu Val Tyr Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser 
        115                 120                 125             


Gln Leu Phe Asp His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys 
    130                 135                 140                 


Arg Lys Ile Lys Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe 
145                 150                 155                 160 


Pro Cys Gln Gln Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr 
                165                 170                 175     


Lys Arg Phe Lys Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu 
            180                 185                 190         


Leu Asn Lys Ala Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val 
        195                 200                 205             


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp 
    210                 215                 220                 


Asp Gln His Cys Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala 
225                 230                 235                 240 


Cys Tyr Met Glu Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu 
                245                 250                 255     


Gly Arg Met Cys Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly 
            260                 265                 270         


Ser Leu Glu Asp Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly 
        275                 280                 285             


Ser Leu Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met 
    290                 295                 300                 


Tyr Leu Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu 
305                 310                 315                 320 


Gly Leu Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly 
                325                 330                 335     


Lys Phe Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly 
            340                 345                 350         


Leu His Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser 
        355                 360                 365             


Asp Asp Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe 
    370                 375                 380                 


Arg Ser Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg 
385                 390                 395                 400 


Leu Arg Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val 
                405                 410                 415     


Asp Gly Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His 
            420                 425                 430         


Lys Thr Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu 
        435                 440                 445             


Ser Glu Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala 
    450                 455                 460                 


Tyr Arg Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His 
465                 470                 475                 480 


Phe His Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg 
                485                 490                 495     


Ala Glu Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val 
            500                 505                 510         


Val Lys Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu 
        515                 520                 525             


Asn Gly Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val 
    530                 535                 540                 


Leu Leu Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His 
545                 550                 555                 560 


Asn Lys Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu 
                565                 570                 575     


Glu Leu Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr 
            580                 585                 590         


Met Gly Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe 
        595                 600                 605             


Pro Cys Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr 
    610                 615                 620                 


Lys Gly Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu 
625                 630                 635                 640 


Leu Arg Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val 
                645                 650                 655     


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu 
            660                 665                 670         


Glu Pro Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala 
        675                 680                 685             


Cys Tyr Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln 
    690                 695                 700                 


Gly Gln Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly 
705                 710                 715                 720 


Cys Leu Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr 
                725                 730                 735     


Ser Leu Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met 
            740                 745                 750         


Tyr Leu Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys 
        755                 760                 765             


Gly Phe Leu Phe Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly 
    770                 775                 780                 


Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala 
785                 790                 795                 800 


Leu Leu Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr 
                805                 810                 815     


Cys Asp Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg 
            820                 825                 830         


Arg Ala Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys 
        835                 840                 845             


Ile Arg Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val 
    850                 855                 860                 


Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His 
865                 870                 875                 880 


Gln Thr Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu 
                885                 890                 895     


Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly 
            900                 905                 910         


Val Arg Leu Arg Thr Glu Ala Ser Ser 
        915                 920     


<210>  24
<211>  905
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Hexokinase-1 Isoform 4

<400>  24

Met Ala Lys Arg Ala Leu His Asp Phe Ile Asp Lys Tyr Leu Tyr Ala 
1               5                   10                  15      


Met Arg Leu Ser Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg 
            20                  25                  30          


Lys Glu Met Lys Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr 
        35                  40                  45              


Val Lys Met Leu Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu 
    50                  55                  60                  


Lys Gly Asp Phe Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile 
65                  70                  75                  80  


Leu Arg Val Gln Val Asn His Glu Lys Asn Gln Asn Val His Met Glu 
                85                  90                  95      


Ser Glu Val Tyr Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser 
            100                 105                 110         


Gln Leu Phe Asp His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys 
        115                 120                 125             


Arg Lys Ile Lys Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe 
    130                 135                 140                 


Pro Cys Gln Gln Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr 
145                 150                 155                 160 


Lys Arg Phe Lys Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu 
                165                 170                 175     


Leu Asn Lys Ala Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val 
            180                 185                 190         


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp 
        195                 200                 205             


Asp Gln His Cys Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala 
    210                 215                 220                 


Cys Tyr Met Glu Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu 
225                 230                 235                 240 


Gly Arg Met Cys Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly 
                245                 250                 255     


Ser Leu Glu Asp Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly 
            260                 265                 270         


Ser Leu Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met 
        275                 280                 285             


Tyr Leu Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu 
    290                 295                 300                 


Gly Leu Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly 
305                 310                 315                 320 


Lys Phe Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly 
                325                 330                 335     


Leu His Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser 
            340                 345                 350         


Asp Asp Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe 
        355                 360                 365             


Arg Ser Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg 
    370                 375                 380                 


Leu Arg Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val 
385                 390                 395                 400 


Asp Gly Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His 
                405                 410                 415     


Lys Thr Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu 
            420                 425                 430         


Ser Glu Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala 
        435                 440                 445             


Tyr Arg Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His 
    450                 455                 460                 


Phe His Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg 
465                 470                 475                 480 


Ala Glu Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val 
                485                 490                 495     


Val Lys Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu 
            500                 505                 510         


Asn Gly Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val 
        515                 520                 525             


Leu Leu Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His 
    530                 535                 540                 


Asn Lys Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu 
545                 550                 555                 560 


Glu Leu Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr 
                565                 570                 575     


Met Gly Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe 
            580                 585                 590         


Pro Cys Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr 
        595                 600                 605             


Lys Gly Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu 
    610                 615                 620                 


Leu Arg Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val 
625                 630                 635                 640 


Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu 
                645                 650                 655     


Glu Pro Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala 
            660                 665                 670         


Cys Tyr Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln 
        675                 680                 685             


Gly Gln Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly 
    690                 695                 700                 


Cys Leu Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr 
705                 710                 715                 720 


Ser Leu Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met 
                725                 730                 735     


Tyr Leu Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys 
            740                 745                 750         


Gly Phe Leu Phe Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly 
        755                 760                 765             


Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala 
    770                 775                 780                 


Leu Leu Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr 
785                 790                 795                 800 


Cys Asp Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg 
                805                 810                 815     


Arg Ala Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys 
            820                 825                 830         


Ile Arg Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val 
        835                 840                 845             


Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His 
    850                 855                 860                 


Gln Thr Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu 
865                 870                 875                 880 


Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly 
                885                 890                 895     


Val Arg Leu Arg Thr Glu Ala Ser Ser 
            900                 905 


