                         SEQUENCE LISTING

<110>         CCAM BIOTHERAPEUTICS LTD.
 
<120>  COMPOSITIONS COMPRISING ANTI-CEACAM1 ANTIBODIES, LYMPHOCYTE ACTIVATING AGENTS AND ACTIVATED LYMPHOCYTES FOR CANCER THERAPY

<130>  CCAM 007 PCT

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Absent or Thr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Absent or Ile

<400>  1

Xaa Asn Asn Leu Xaa 
1               5   


<210>  2
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  2

Ile Asn Pro Gly Ser Gly Asp Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  3

Gly Asp Tyr Tyr Gly Gly Phe Ala Val Asp Tyr 
1               5                   10      


<210>  4
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Asp Ile Gly Asn Tyr 
1               5       


<210>  5
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  5

Tyr Thr Ser Arg 
1               


<210>  6
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Gln Gly Lys Ser Leu Pro 
1               5           


<210>  7
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  7

Asn Asn Leu Ile Glu 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  8

Val Ile Asn Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Asp Tyr Tyr Gly Gly Phe Ala Val Asp Tyr 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Thr Ser Gln Asp Ile Gly Asn Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Gln Gly Lys Ser Leu Pro 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  13

Gly Tyr Ala Phe Thr Asn Asn Leu 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  14

Ile Asn Pro Gly Ser Gly Asp Thr 
1               5               


<210>  15
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  15

Ala Arg Gly Asp Tyr Tyr Gly Gly Phe Ala Val Asp Tyr 
1               5                   10              


<210>  16
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Asp Ile Gly Asn Tyr 
1               5       


<210>  17
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  17

Tyr Thr Ser Arg 
1               


<210>  18
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  18

Gln Gln Gly Lys Ser Leu Pro Arg Thr 
1               5                   


<210>  19
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  19

Gly Tyr Ala Phe Thr Asn Asn Leu Ile Glu 
1               5                   10  


<210>  20
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  20

Val Ile Asn Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  21

Ala Arg Gly Asp Tyr Tyr Gly Gly Phe Ala Val Asp Tyr 
1               5                   10              


<210>  22
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  22

Arg Thr Ser Gln Asp Ile Gly Asn Tyr Leu Asn 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  23

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Gln Gly Lys Ser Leu Pro Arg Thr 
1               5                   


<210>  25
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Asn 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Gly Phe Ala Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  26

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  450
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Asn 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Gly Gly Phe Ala Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  28
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  28

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Ser Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  29
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe 
1               5                   10              


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  30

Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr 
1               5                   10          


<210>  31
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  31

Pro Asn Ala Ser Leu Leu Ile 
1               5           





