                         SEQUENCE LISTING

<110>  Yale University
       van den Pol, Anthony N
       Wollmann, Guido
 
<120>  CHIMERIC VSV VIRUS COMPOSITIONS AND METHODS OF USE THEREOF FOR 
       TREATMENT OF CANCER

<130>  YU 6290 PCT

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  3401
<212>  DNA
<213>  Lassa virus

<400>  1
cgcaccgggg atcctaggca tttttggttg cgcaattcaa gtgtcctatt taaaatggga       60

caaatagtga cattcttcca ggaagtgcct catgtaatag aagaggtgat gaacattgtt      120

ctcattgcac tgtctgtact agcagtgctg aaaggtctgt acaattttgc aacgtgtggc      180

cttgttggtt tggtcacttt cctcctgttg tgtggtaggt cttgcacaac cagtctttat      240

aaaggggttt atgagcttca gactctggaa ctaaacatgg agacactcaa tatgaccatg      300

cctctctcct gcacaaagaa caacagtcat cattatataa tggtgggcaa tgagacagga      360

ctagaactga ccttgaccaa cacgagcatt attaatcaca aattttgcaa tctgtctgat      420

gcccacaaaa agaacctcta tgaccacgct cttatgagca taatctcaac tttccacttg      480

tccatcccca acttcaatca gtatgaggca atgagctgcg attttaatgg gggaaagatt      540

agtgtgcagt acaacctgag tcacagctat gctggggatg cagccaacca ttgtggtact      600

gttgcaaatg gtgtgttaca gacttttatg aggatggctt ggggtgggag ctacattgct      660

cttgactcag gccgtggcaa ctgggactgt attatgacta gttatcaata tctgataatc      720

caaaatacaa cctgggaaga tcactgccaa ttctcgagac catctcccat cggttatctc      780

gggctcctct cacaaaggac tagagatatt tatattagta gaagattgct aggcacattc      840

acatggacac tgtcagattc tgaaggtaaa gacacaccag ggggatattg tctgaccagg      900

tggatgctaa ttgaggctga actaaaatgc ttcgggaaca cagctgtggc aaaatgtaat      960

gagaagcatg atgaggaatt ttgtgacatg ctgaggctgt ttgacttcaa caaacaagcc     1020

attcaaaggt tgaaagctga agcacaaatg agcattcagt tgatcaacaa agcagtaaat     1080

gctttgataa atgaccaact tataatgaag aaccatctac gggacatcat gggaattcca     1140

tactgtaatt acagcaagta ttggtacctc aaccacacaa ctactgggag aacatcactg     1200

cccaaatgtt ggcttgtatc aaatggttca tacttgaacg agacccactt ttctgatgat     1260

attgaacaac aagctgacaa tatgatcact gagatgttac agaaggagta tatggagagg     1320

caggggaaga caccattggg tctagttgac ctctttgtgt tcagtacaag tttctatctt     1380

attagcatct tccttcacct agtcaaaata ccaactcata ggcatattgt aggcaagtcg     1440

tgtcccaaac ctcacagatt gaatcatatg ggcatttgtt cctgtggact ctacaaacag     1500

cctggtgtgc ctgtgaaatg gaagagatga gacccttgtc agggcccccg tgacccaccg     1560

cctattggcg gtgggtcacg ggggcgtcca tttacagaac gactctaggt gtcgatgttc     1620

tgaacaccat atctctgggc agcactgctc tcaaaaccga tgtgttcagt cctcctgaca     1680

ctgctgcatc aaacatgatg cagtccatta gtgcacagtg aggggttatt tcctctttac     1740

cgcctctttt cttcttttca acaacgacac ctgtgtgcat gtggcataag tctttatact     1800

ggtcccagac tgcattttca tacttcctgg aatcagtttt gctgagggca atatcaatta     1860

gtttaatgtc ttttcttcct tgtgattcaa ggagtttcct tatgtcatcg gacccctgac     1920

aggtaatgac catattccgg gggagtgcat caatgacagc actggtcaag cccggttgtg     1980

tagcgaagag gtctgtgaca tcaatcccat gtgagtactt agcatcctgc ttgaactgct     2040

ttaaatcagt aggttcacgg aagaagtgta tgtagcagcc tgaacttggt tgatagaggg     2100

caatttccac tggatcttca ggtcttcctt caatgtccat ccaggtctta gcatttgggt     2160

caagttgcag cattgcatcc ttgagggtca tcagctgaga ataggtaagc ccagcggtaa     2220

accctgccga ctgcagggat ttactggaat tgttgctgtc agctttctgt ggcttcccat     2280

ctgattccag atcaacgaca gtgttttccc aggcccttcc tgttattgag gttcttgatg     2340

caatatatgg ccatccatct cctgacaaac aaatcttgta gagtatgttt tcataaggat     2400

tcctttcacc aggggtgtct gaaatgaaca ttccaagagc cttcttgacc tttaaaatgg     2460

atttgaggat accatccatt gtctgaggtg acaccttgat tgtctccaac atattgccac     2520

catccagcat gcaagctcct gccttcacag ctgcacccaa gctaaaatta taacctgaga     2580

tattcaaaga gcttttcttg gtgtcaatca tatttaggat gggatgactt tgagtcagcc     2640

tgtctaagtc tgaagtgttg ggatactttg ctgtgtagat caaacccaaa tctgtcaatg     2700

cttgtactgc atcattcaag tcaacctgcc cctgttttgt cagacatgcc agtgtcagac     2760

ttggcatggt cccgaactga ttattgagca actctgcatt tttcacatcc caaactctca     2820

ccactccatc tctcccagcc cgagcccctt gattaccacc actcattcct atcatattca     2880

ggagagctct tctttggtca agttgctgtg agcttaggtt gcccatatag acacctgcac     2940

ttaatggcct ttctgttctg atcacctttg actttaactt ctctagatca gcggctaaga     3000

ttaataagtc atctgaggtt agagtcccaa ctctcagtat actcttttgt tgagttgatt     3060

ttaattcaac aagattgttg accgcttgat ttaggtccct caaccgtttc aaatcattgt     3120

catcccttct ctccttgcgc atcaaccgtt gaacattact gacttcggag aagtcaagtc     3180

catgtaaaag agcctgggca tctttcacca cctgtagttt gatgttggag cagtaaccag     3240

ataattccct cctcaaagat tgtgtccaca aaaaggattt tatttccttt gaggcactca     3300

tcgccagatt gttgtgttgt atgcacgcaa caaagaactg agactatctg ccaaaatgac     3360

aaaagcaaag cgcaatccaa tagcctagga tccactgtgc g                         3401


<210>  2
<211>  491
<212>  PRT
<213>  Lassa virus

<400>  2

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Arg Gly 
        195                 200                 205             


Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
    210                 215                 220                 


Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile Gly 
225                 230                 235                 240 


Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser Arg 
                245                 250                 255     


Arg Leu Leu Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly Lys 
            260                 265                 270         


Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu Ala 
        275                 280                 285             


Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu Lys 
    290                 295                 300                 


His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn Lys 
305                 310                 315                 320 


Gln Ala Ile Gln Arg Leu Lys Ala Glu Ala Gln Met Ser Ile Gln Leu 
                325                 330                 335     


Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met Lys 
            340                 345                 350         


Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser Lys 
        355                 360                 365             


Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro Lys 
    370                 375                 380                 


Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser 
385                 390                 395                 400 


Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu Gln 
                405                 410                 415     


Lys Glu Tyr Met Glu Arg Gln Gly Lys Thr Pro Leu Gly Leu Val Asp 
            420                 425                 430         


Leu Phe Val Phe Ser Thr Ser Phe Tyr Leu Ile Ser Ile Phe Leu His 
        435                 440                 445             


Leu Val Lys Ile Pro Thr His Arg His Ile Val Gly Lys Ser Cys Pro 
    450                 455                 460                 


Lys Pro His Arg Leu Asn His Met Gly Ile Cys Ser Cys Gly Leu Tyr 
465                 470                 475                 480 


Lys Gln Pro Gly Val Pro Val Lys Trp Lys Arg 
                485                 490     


<210>  3
<211>  569
<212>  PRT
<213>  Lassa virus

<400>  3

Met Ser Ala Ser Lys Glu Ile Lys Ser Phe Leu Trp Thr Gln Ser Leu 
1               5                   10                  15      


Arg Arg Glu Leu Ser Gly Tyr Cys Ser Asn Ile Lys Leu Gln Val Val 
            20                  25                  30          


Lys Asp Ala Gln Ala Leu Leu His Gly Leu Asp Phe Ser Glu Val Ser 
        35                  40                  45              


Asn Val Gln Arg Leu Met Arg Lys Glu Arg Arg Asp Asp Asn Asp Leu 
    50                  55                  60                  


Lys Arg Leu Arg Asp Leu Asn Gln Ala Val Asn Asn Leu Val Glu Leu 
65                  70                  75                  80  


Lys Ser Thr Gln Gln Lys Ser Ile Leu Arg Val Gly Thr Leu Thr Ser 
                85                  90                  95      


Asp Asp Leu Leu Ile Leu Ala Ala Asp Leu Glu Lys Leu Lys Ser Lys 
            100                 105                 110         


Val Ile Arg Thr Glu Arg Pro Leu Ser Ala Gly Val Tyr Met Gly Asn 
        115                 120                 125             


Leu Ser Ser Gln Gln Leu Asp Gln Arg Arg Ala Leu Leu Asn Met Ile 
    130                 135                 140                 


Gly Met Ser Gly Gly Asn Gln Gly Ala Arg Ala Gly Arg Asp Gly Val 
145                 150                 155                 160 


Val Arg Val Trp Asp Val Lys Asn Ala Glu Leu Leu Asn Asn Gln Phe 
                165                 170                 175     


Gly Thr Met Pro Ser Leu Thr Leu Ala Cys Leu Thr Lys Gln Gly Gln 
            180                 185                 190         


Val Asp Leu Asn Asp Ala Val Gln Ala Leu Thr Asp Leu Gly Leu Ile 
        195                 200                 205             


Tyr Thr Ala Lys Tyr Pro Asn Thr Ser Asp Leu Asp Arg Leu Thr Gln 
    210                 215                 220                 


Ser His Pro Ile Leu Asn Met Ile Asp Thr Lys Lys Ser Ser Leu Asn 
225                 230                 235                 240 


Ile Ser Gly Tyr Asn Phe Ser Leu Gly Ala Ala Val Lys Ala Gly Ala 
                245                 250                 255     


Cys Met Leu Asp Gly Gly Asn Met Leu Glu Thr Ile Lys Val Ser Pro 
            260                 265                 270         


Gln Thr Met Asp Gly Ile Leu Lys Ser Ile Leu Lys Val Lys Lys Ala 
        275                 280                 285             


Leu Gly Met Phe Ile Ser Asp Thr Pro Gly Glu Arg Asn Pro Tyr Glu 
    290                 295                 300                 


Asn Ile Leu Tyr Lys Ile Cys Leu Ser Gly Asp Gly Trp Pro Tyr Ile 
305                 310                 315                 320 


Ala Ser Arg Thr Ser Ile Thr Gly Arg Ala Trp Glu Asn Thr Val Val 
                325                 330                 335     


Asp Leu Glu Ser Asp Gly Lys Pro Gln Lys Ala Asp Ser Asn Asn Ser 
            340                 345                 350         


Ser Lys Ser Leu Gln Ser Ala Gly Phe Thr Ala Gly Leu Thr Tyr Ser 
        355                 360                 365             


Gln Leu Met Thr Leu Lys Asp Ala Met Leu Gln Leu Asp Pro Asn Ala 
    370                 375                 380                 


Lys Thr Trp Met Asp Ile Glu Gly Arg Pro Glu Asp Pro Val Glu Ile 
385                 390                 395                 400 


Ala Leu Tyr Gln Pro Ser Ser Gly Cys Tyr Ile His Phe Phe Arg Glu 
                405                 410                 415     


Pro Thr Asp Leu Lys Gln Phe Lys Gln Asp Ala Lys Tyr Ser His Gly 
            420                 425                 430         


Ile Asp Val Thr Asp Leu Phe Ala Thr Gln Pro Gly Leu Thr Ser Ala 
        435                 440                 445             


Val Ile Asp Ala Leu Pro Arg Asn Met Val Ile Thr Cys Gln Gly Ser 
    450                 455                 460                 


Asp Asp Ile Arg Lys Leu Leu Glu Ser Gln Gly Arg Lys Asp Ile Lys 
465                 470                 475                 480 


Leu Ile Asp Ile Ala Leu Ser Lys Thr Asp Ser Arg Lys Tyr Glu Asn 
                485                 490                 495     


Ala Val Trp Asp Gln Tyr Lys Asp Leu Cys His Met His Thr Gly Val 
            500                 505                 510         


Val Val Glu Lys Lys Lys Arg Gly Gly Lys Glu Glu Ile Thr Pro His 
        515                 520                 525             


Cys Ala Leu Met Asp Cys Ile Met Phe Asp Ala Ala Val Ser Gly Gly 
    530                 535                 540                 


Leu Asn Thr Ser Val Leu Arg Ala Val Leu Pro Arg Asp Met Val Phe 
545                 550                 555                 560 


Arg Thr Ser Thr Pro Arg Val Val Leu 
                565                 


<210>  4
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  4
gcgacgcgta ccatgggaca aatagtgaca ttct                                   34


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Primer

<400>  5
ggcggccgct catctcttcc atttcacagg                                        30


<210>  6
<211>  2031
<212>  DNA
<213>  Ebola virus Zaire strain

<400>  6
atgggcgtta caggaatatt gcagttacct cgtgatcgat tcaagaggac atcattcttt       60

ctttgggtaa ttatcctttt ccaaagaaca ttttccatcc cacttggagt catccacaat      120

agcacattac aggttagtga tgtcgacaaa ctagtttgtc gtgacaaact gtcatccaca      180

aatcaattga gatcagttgg actgaatctc gaagggaatg gagtggcaac tgacgtgcca      240

tctgcaacta aaagatgggg cttcaggtcc ggtgtcccac caaaggtggt caattatgaa      300

gctggtgaat gggctgaaaa ctgctacaat cttgaaatca aaaaacctga cgggagtgag      360

tgtctaccag cagcgccaga cgggattcgg ggcttccccc ggtgccggta tgtgcacaaa      420

gtatcaggaa cgggaccgtg tgccggagac tttgccttcc ataaagaggg tgctttcttc      480

ctgtatgatc gacttgcttc cacagttatc taccgaggaa cgactttcgc tgaaggtgtc      540

gttgcatttc tgatactgcc ccaagctaag aaggacttct tcagctcaca ccccttgaga      600

gagccggtca atgcaacgga ggacccgtct agtggctact attctaccac aattagatat      660

caggctaccg gttttggaac caatgagaca gagtacttgt tcgaggttga caatttgacc      720

tacgtccaac ttgaatcaag attcacacca cagtttctgc tccagctgaa tgagacaata      780

tatacaagtg ggaaaaggag caataccacg ggaaaactaa tttggaaggt caaccccgaa      840

attgatacaa caatcgggga gtgggccttc tgggaaacta aaaaaaacct cactagaaaa      900

attcgcagtg aagagttgtc tttcacagtt gtatcaaacg gagccaaaaa catcagtggt      960

cagagtccgg cgcgaacttc ttccgaccca gggaccaaca caacaactga agaccacaaa     1020

atcatggctt cagaaaattc ctctgcaatg gttcaagtgc acagtcaagg aagggaagct     1080

gcagtgtcgc atctaacaac ccttgccaca atctccacga gtccccaatc cctcacaacc     1140

aaaccaggtc cggacaacag cacccataat acacccgtgt ataaacttga catctctgag     1200

gcaactcaag ttgaacaaca tcaccgcaga acagacaacg acagcacagc ctccgacact     1260

ccctctgcca cgaccgcagc cggaccccca aaagcagaga acaccaacac gagcaagagc     1320

actgacttcc tggaccccgc caccacaaca agtccccaaa accacagcga gaccgctggc     1380

aacaacaaca ctcatcacca agataccgga gaagagagtg ccagcagcgg gaagctaggc     1440

ttaattacca atactattgc tggagtcgca ggactgatca caggcgggag aagaactcga     1500

agagaagcaa ttgtcaatgc tcaacccaaa tgcaacccta atttacatta ctggactact     1560

caggatgaag gtgctgcaat cggactggcc tggataccat atttcgggcc agcagccgag     1620

ggaatttaca tagaggggct aatgcacaat caagatggtt taatctgtgg gttgagacag     1680

ctggccaacg agacgactca agctcttcaa ctgttcctga gagccacaac tgagctacgc     1740

accttttcaa tcctcaaccg taaggcaatt gatttcttgc tgcagcgatg gggcggcaca     1800

tgccacattc tgggaccgga ctgctgtatc gaaccacatg attggaccaa gaacataaca     1860

gacaaaattg atcagattat tcatgatttt gttgataaaa cccttccgga ccagggggac     1920

aatgacaatt ggtggacagg atggagacaa tggataccgg caggtattgg agttacaggc     1980

gttataattg cagttatcgc tttattctgt atatgcaaat ttgtctttta g              2031


<210>  7
<211>  676
<212>  PRT
<213>  Ebola virus Zaire strain

<400>  7

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Asn Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Thr Val Val Ser Asn Gly Ala Lys Asn Ile Ser Gly 
305                 310                 315                 320 


Gln Ser Pro Ala Arg Thr Ser Ser Asp Pro Gly Thr Asn Thr Thr Thr 
                325                 330                 335     


Glu Asp His Lys Ile Met Ala Ser Glu Asn Ser Ser Ala Met Val Gln 
            340                 345                 350         


Val His Ser Gln Gly Arg Glu Ala Ala Val Ser His Leu Thr Thr Leu 
        355                 360                 365             


Ala Thr Ile Ser Thr Ser Pro Gln Ser Leu Thr Thr Lys Pro Gly Pro 
    370                 375                 380                 


Asp Asn Ser Thr His Asn Thr Pro Val Tyr Lys Leu Asp Ile Ser Glu 
385                 390                 395                 400 


Ala Thr Gln Val Glu Gln His His Arg Arg Thr Asp Asn Asp Ser Thr 
                405                 410                 415     


Ala Ser Asp Thr Pro Ser Ala Thr Thr Ala Ala Gly Pro Pro Lys Ala 
            420                 425                 430         


Glu Asn Thr Asn Thr Ser Lys Ser Thr Asp Phe Leu Asp Pro Ala Thr 
        435                 440                 445             


Thr Thr Ser Pro Gln Asn His Ser Glu Thr Ala Gly Asn Asn Asn Thr 
    450                 455                 460                 


His His Gln Asp Thr Gly Glu Glu Ser Ala Ser Ser Gly Lys Leu Gly 
465                 470                 475                 480 


Leu Ile Thr Asn Thr Ile Ala Gly Val Ala Gly Leu Ile Thr Gly Gly 
                485                 490                 495     


Arg Arg Thr Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn 
            500                 505                 510         


Pro Asn Leu His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly 
        515                 520                 525             


Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile 
    530                 535                 540                 


Glu Gly Leu Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln 
545                 550                 555                 560 


Leu Ala Asn Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr 
                565                 570                 575     


Thr Glu Leu Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Gln Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Glu Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp 
    610                 615                 620                 


Gln Ile Ile His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp 
625                 630                 635                 640 


Asn Asp Asn Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile 
                645                 650                 655     


Gly Val Thr Gly Val Ile Ile Ala Val Ile Ala Leu Phe Cys Ile Cys 
            660                 665                 670         


Lys Phe Val Phe 
        675     


<210>  8
<211>  1494
<212>  DNA
<213>  Ebola virus Zaire strain

<400>  8
atgggcgtta caggaatatt gcagttacct cgtgatcgat tcaagaggac atcattcttt       60

ctttgggtaa ttatcctttt ccaaagaaca ttttccatcc cacttggagt catccacagt      120

agcacattac aggttagtga tgtcgacaaa ctagtttgtc gtgacaaact gtcatccaca      180

aatcaattga gatcagttgg actgaatctc gaagggaatg gagtggcaac tgacgtgcca      240

tctgcaacta aaagatgggg cttcaggtcc ggtgtcccac caaaggtggt caattatgaa      300

gctggtgaat gggctgaaaa ctgctacaat cttgaaatca aaaaacctga cgggagtgag      360

tgtctaccag cagcgccaga cgggattcgg ggcttccccc ggtgccggta tgtgcacaaa      420

gtatcaggaa cgggaccgtg tgccggagac tttgccttcc ataaagaggg tgctttcttc      480

ctgtatgatc gacttgcttc cacagttatc taccgaggaa cgactttcgc tgaaggtgtc      540

gttgcatttc tgatactgcc ccaagctaag aaggacttct tcagctcaca ccccttgaga      600

gagccggtca atgcaacgga ggacccgtct agtggctact attctaccac aattagatat      660

caggctaccg gttttggaac caatgagaca gagtacttgt tcgaggttga caatttgacc      720

tacgtccaac ttgaatcaag attcacacca cagtttctgc tccagctgaa tgagacaata      780

tatacaagtg ggaaaaggag caataccacg ggaaaactaa tttggaaggt caaccccgaa      840

attgatacaa caatcgggga gtgggccttc tgggaaacta aaaaaaacct cactagaaaa      900

attcgcagtg aagagttgtc tttctctaga gcaggactga tcacaggcgg gagaagaact      960

cgaagagaag caattgtcaa tgctcaaccc aaatgcaacc ctaatttaca ttactggact     1020

actcaggatg aaggtgctgc aatcggactg gcctggatac catatttcgg gccagcagcc     1080

gagggaattt acatagaggg gctaatgcac aatcaagatg gtttaatctg tgggttgaga     1140

cagctggcca acgagacgac tcaagctctt caactgttcc tgagagccac aactgagcta     1200

cgcacctttt caatcctcaa ccgtaaggca attgatttct tgctgcagcg atggggcggc     1260

acatgccaca ttctgggacc ggactgctgt atcgaaccac atgattggac caagaacata     1320

acagacaaaa ttgatcagat tattcatgat tttgttgata aaacccttcc ggaccagggg     1380

gacaatgaca attggtggac aggatggaga caatggatac cggcaggtat tggagttaca     1440

ggcgttgtaa ttgcagttat cgctttattc tgtatatgca aatttgtctt ttag           1494


<210>  9
<211>  497
<212>  PRT
<213>  Ebola virus Zaire strain

<400>  9

Met Gly Val Thr Gly Ile Leu Gln Leu Pro Arg Asp Arg Phe Lys Arg 
1               5                   10                  15      


Thr Ser Phe Phe Leu Trp Val Ile Ile Leu Phe Gln Arg Thr Phe Ser 
            20                  25                  30          


Ile Pro Leu Gly Val Ile His Ser Ser Thr Leu Gln Val Ser Asp Val 
        35                  40                  45              


Asp Lys Leu Val Cys Arg Asp Lys Leu Ser Ser Thr Asn Gln Leu Arg 
    50                  55                  60                  


Ser Val Gly Leu Asn Leu Glu Gly Asn Gly Val Ala Thr Asp Val Pro 
65                  70                  75                  80  


Ser Ala Thr Lys Arg Trp Gly Phe Arg Ser Gly Val Pro Pro Lys Val 
                85                  90                  95      


Val Asn Tyr Glu Ala Gly Glu Trp Ala Glu Asn Cys Tyr Asn Leu Glu 
            100                 105                 110         


Ile Lys Lys Pro Asp Gly Ser Glu Cys Leu Pro Ala Ala Pro Asp Gly 
        115                 120                 125             


Ile Arg Gly Phe Pro Arg Cys Arg Tyr Val His Lys Val Ser Gly Thr 
    130                 135                 140                 


Gly Pro Cys Ala Gly Asp Phe Ala Phe His Lys Glu Gly Ala Phe Phe 
145                 150                 155                 160 


Leu Tyr Asp Arg Leu Ala Ser Thr Val Ile Tyr Arg Gly Thr Thr Phe 
                165                 170                 175     


Ala Glu Gly Val Val Ala Phe Leu Ile Leu Pro Gln Ala Lys Lys Asp 
            180                 185                 190         


Phe Phe Ser Ser His Pro Leu Arg Glu Pro Val Asn Ala Thr Glu Asp 
        195                 200                 205             


Pro Ser Ser Gly Tyr Tyr Ser Thr Thr Ile Arg Tyr Gln Ala Thr Gly 
    210                 215                 220                 


Phe Gly Thr Asn Glu Thr Glu Tyr Leu Phe Glu Val Asp Asn Leu Thr 
225                 230                 235                 240 


Tyr Val Gln Leu Glu Ser Arg Phe Thr Pro Gln Phe Leu Leu Gln Leu 
                245                 250                 255     


Asn Glu Thr Ile Tyr Thr Ser Gly Lys Arg Ser Asn Thr Thr Gly Lys 
            260                 265                 270         


Leu Ile Trp Lys Val Asn Pro Glu Ile Asp Thr Thr Ile Gly Glu Trp 
        275                 280                 285             


Ala Phe Trp Glu Thr Lys Lys Asn Leu Thr Arg Lys Ile Arg Ser Glu 
    290                 295                 300                 


Glu Leu Ser Phe Ser Arg Ala Gly Leu Ile Thr Gly Gly Arg Arg Thr 
305                 310                 315                 320 


Arg Arg Glu Ala Ile Val Asn Ala Gln Pro Lys Cys Asn Pro Asn Leu 
                325                 330                 335     


His Tyr Trp Thr Thr Gln Asp Glu Gly Ala Ala Ile Gly Leu Ala Trp 
            340                 345                 350         


Ile Pro Tyr Phe Gly Pro Ala Ala Glu Gly Ile Tyr Ile Glu Gly Leu 
        355                 360                 365             


Met His Asn Gln Asp Gly Leu Ile Cys Gly Leu Arg Gln Leu Ala Asn 
    370                 375                 380                 


Glu Thr Thr Gln Ala Leu Gln Leu Phe Leu Arg Ala Thr Thr Glu Leu 
385                 390                 395                 400 


Arg Thr Phe Ser Ile Leu Asn Arg Lys Ala Ile Asp Phe Leu Leu Gln 
                405                 410                 415     


Arg Trp Gly Gly Thr Cys His Ile Leu Gly Pro Asp Cys Cys Ile Glu 
            420                 425                 430         


Pro His Asp Trp Thr Lys Asn Ile Thr Asp Lys Ile Asp Gln Ile Ile 
        435                 440                 445             


His Asp Phe Val Asp Lys Thr Leu Pro Asp Gln Gly Asp Asn Asp Asn 
    450                 455                 460                 


Trp Trp Thr Gly Trp Arg Gln Trp Ile Pro Ala Gly Ile Gly Val Thr 
465                 470                 475                 480 


Gly Val Val Ile Ala Val Ile Ala Leu Phe Cys Ile Cys Lys Phe Val 
                485                 490                 495     


Phe 
    


