                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  ADENO-ASSOCIATED VIRUS VECTORS FOR TREATMENT OF GLYCOGEN STORAGE 
       DISEASE

<130>  4239-91776-02

<150>  US 61/908,861
<151>  2013-11-26

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  7671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (plasmid UF11-GPE-G6PC)


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  Inverted terminal repeat

<220>
<221>  misc_feature
<222>  (182)..(3045)
<223>  G6PC promoter/enhancer

<220>
<221>  misc_feature
<222>  (3051)..(3184)
<223>  Stuffer sequence

<220>
<221>  misc_feature
<222>  (3185)..(3321)
<223>  Intron

<220>
<221>  misc_feature
<222>  (3322)..(3367)
<223>  Stuffer sequence

<220>
<221>  misc_feature
<222>  (3368)..(4441)
<223>  G6PC coding sequence

<220>
<221>  misc_feature
<222>  (4674)..(4819)
<223>  Inverted terminal repeat

<400>  1
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

ccctttgaga atccacggtg tctcgatgca gtcagctttc taacaagctg gggcctcacc      240

tgttttccca cggataaaaa cgtgctggag gaagcagaaa ggggctggca ggtggaaaga      300

tgaggaccag ctcatcgtct catgactatg aggttgctct gatccagagg gtccccctgc      360

ctggtggccc accgccagga agactcccac tgtccctgga tgcccagagt gggatgtcaa      420

ctccatcact tatcaactcc ttatccatag gggtattctt cctgaggcgt ctcagaaaac      480

agggccctcc ccatatgctg accacataat agaacccctc ccaactcaga gaccctggct      540

gctagctgcc ctggcatgac ccagacagtg gcctttgtat atgtttttag actcaccttg      600

actcacctct gaccatagaa actctcatcc cagaggtcac tgcaatagtt actccacaac      660

agaggcttat ctgggtagag ggaggctccc tacctatggc ccagcagccc tgacagtgca      720

gatcacatat accccacgcc ccagcactgc ctgccacgca tgggcttact ttacacccac      780

ccacagtcac caacacatta cctgctctcc aaggttaggc gtggcaggag aagtttgctt      840

ggaccagcag aaaccatgca gtcaaggaca actggagtca gcatgggctg ggtgcgagcc      900

cttggtgggg tggggaggag actccaggtc atacctcctg gaggatgttt taatcatttc      960

cagcatggaa tgctgtcaac ttttgccaca gattcattag ctctgagttt cttttttctg     1020

tccccagcta ccccttacat gtcaatatgg acttaatgat gggaaattca ggcaagtttt     1080

taaacatttt attccccctg gctcttatcc tcaaaaaatg catgaatttg gaggcagtgg     1140

ctcatgcctg taatcccaat gctttgctag gttgaggcgg gaggatcact tgaagccagg     1200

aatttgagac cagcctgggc cgcatagtga gaccccgttt ctacaaaaat aaataaataa     1260

ataataaata atagtgatat gaagcatgat taaatagccc tattttttaa aatgcatgag     1320

ttcgttacct gattcattcc ctggttcctt tcacagtcct ccgtgaccca agtgttaggg     1380

ttttggtctc tctactattt gtaggctgat atatagtata cacacacaca cacacacaca     1440

tatacacaca cacagtgtat cttgagcttt cttttgtata tctacacaca tatgtataag     1500

aaagctcaag atatagaagc cctttttcaa aaataactga aagtttcaaa ctctttaagt     1560

ctccagttac cattttgctg gtattcttat ttggaaccat acattcatca tattgttgca     1620

cagtaagact atacattcat tattttgctt aaacgtatga gttaaaacac ttggccaggc     1680

atggtggttc acacctgtaa tcccagagct ttgggaagcc aagactggca gatctcttga     1740

gctcaggaat tcaagaccag cctgggcaac atggaaaaac cccatctcta caaaagatag     1800

aaaaattagc caggcatggt ggcgtgtgcc tgtggtccca gctactcagg aggctgaggt     1860

gggaggatca cattagccca ggaggttgag gctgcagtga gccgtgatta tgccactgca     1920

ctccagcctg ggagacagag tgagaccctg tttcaaaaaa aagagagaga aaatttaaaa     1980

aagaaaacaa caccaagggc tgtaacttta aggtcattaa atgaattaat cactgcattc     2040

aaaaacgatt actttctggc cctaagagac atgaggccaa taccaggaag ggggttgatc     2100

tcccaaacca gaggcagacc ctagactcta atacagttaa ggaaagacca gcaagatgat     2160

agtccccaat acaatagaag ttactatatt ttatttgttg tttttctttt gttttgtttt     2220

gttttgtttt gttttgtttt agagactggg gtcttgctcg attgcccagg ctgtagtgca     2280

gcggtgggac aatagctcac tgcagactcc aactcctggg ctcaagcaat cctcctgcct     2340

cagcctcctg aatagctggg actacaaggg tacaccatca cacacaccaa aacaattttt     2400

taaatttttg tgtagaaacg agggtcttgc tttgttgccc aggctggtct ccaactcctg     2460

gcttcaaggg atcctcccac ctcagcctcc caaattgctg ggattacagg tgtgagccac     2520

cacaaccagc cagaacttta ctaattttaa aattaagaac ttaaaacttg aatagctaga     2580

gcaccaagat ttttctttgt ccccaaataa gtgcagttgc aggcatagaa aatctgacat     2640

ctttgcaaga atcatcgtgg atgtagactc tgtcctgtgt ctctggcctg gtttcgggga     2700

ccaggagggc agacccttgc actgccaaga agcatgccaa agttaatcat tggccctgct     2760

gagtacatgg ccgatcaggc tgtttttgtg tgcctgtttt tctattttac gtaaatcacc     2820

ctgaacatgt ttgcatcaac ctactggtga tgcacctttg atcaatacat tttagacaaa     2880

cgtggttttt gagtccaaag atcagggctg ggttgacctg aatactggat acagggcata     2940

taaaacaggg gcaaggcaca gactcatagc agagcaatca ccaccaagcc tggaataact     3000

gcaagggctc tgctgacatc ttcctgaggt gccaaggaaa tgaggtctag agaagcttta     3060

ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac acaacagtct     3120

cgaacttaag ctgcagtgac tctcttaagg tagccttgca gaagttggtc gtgaggcact     3180

gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa actgggcttg     3240

tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac     3300

tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggccctgca     3360

ggccaccatg gaggaaggaa tgaatgttct ccatgacttt gggatccagt caacacatta     3420

cctccaggtg aattaccaag actcccagga ctggttcatc ttggtgtccg tgatcgcaga     3480

cctcaggaat gccttctacg tcctcttccc catctggttc catcttcagg aagctgtggg     3540

cattaaactc ctttgggtag ctgtgattgg agactggctc aacctcgtct ttaagtggat     3600

tctctttgga cagcgtccat actggtgggt tttggatact gactactaca gcaacacttc     3660

cgtgcccctg ataaagcagt tccctgtaac ctgtgagact ggaccaggga gcccctctgg     3720

ccatgccatg ggcacagcag gtgtatacta cgtgatggtc acatctactc tttccatctt     3780

tcagggaaag ataaagccga cctacagatt tcggtgcttg aatgtcattt tgtggttggg     3840

attctgggct gtgcagctga atgtctgtct gtcacgaatc taccttgctg ctcattttcc     3900

tcatcaagtt gttgctggag tcctgtcagg cattgctgtt gcagaaactt tcagccacat     3960

ccacagcatc tataatgcca gcctcaagaa atattttctc attaccttct tcctgttcag     4020

cttcgccatc ggattttatc tgctgctcaa gggactgggt gtagacctcc tgtggactct     4080

ggagaaagcc cagaggtggt gcgagcagcc agaatgggtc cacattgaca ccacaccctt     4140

tgccagcctc ctcaagaacc tgggcacgct ctttggcctg gggctggctc tcaactccag     4200

catgtacagg gagagctgca aggggaaact cagcaagtgg ctcccattcc gcctcagctc     4260

tattgtagcc tccctcgtcc tcctgcacgt ctttgactcc ttgaaacccc catcccaagt     4320

cgagctggtc ttctacgtct tgtccttctg caagagtgcg gtagtgcccc tggcatccgt     4380

cagtgtcatc ccctactgcc tcgcccaggt cctgggccag ccgcacaaga agtcgttgta     4440

agcggccgcg gggatccaga catgataaga tacattgatg agtttggaca aaccacaact     4500

agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta     4560

accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag     4620

gttcaggggg aggtgtggga ggttttttag tcgaccatgc tggggagaga tctaggaacc     4680

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgcccg     4740

ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg     4800

cagagaggga gtggccaacc cccccccccc cccccctgca gccctgcatt aatgaatcgg     4860

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga     4920

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     4980

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     5040

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     5100

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     5160

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     5220

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc     5280

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     5340

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     5400

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     5460

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     5520

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     5580

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     5640

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     5700

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     5760

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     5820

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg     5880

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga     5940

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc     6000

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac     6060

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc     6120

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc     6180

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc     6240

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt     6300

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc     6360

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg     6420

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag     6480

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat     6540

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc     6600

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa     6660

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta     6720

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     6780

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga     6840

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct     6900

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac     6960

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt     7020

tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca     7080

ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggaaatt     7140

gtaaacgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt     7200

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg     7260

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc     7320

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca     7380

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga     7440

tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa     7500

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc     7560

gccgcgctta atgcgccgct acagggcgcg tcgcgccatt cgccattcag gctacgcaac     7620

tgttgggaag ggcgatcggt gcgggcctct tcgctattac gccaggctgc a              7671


<210>  2
<211>  7505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (plasmid UF11-K29-G6PC)


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  Inverted terminal repeat

<220>
<221>  misc_feature
<222>  (182)..(3045)
<223>  G6PC promoter/enhancer

<220>
<221>  misc_feature
<222>  (3052)..(3188)
<223>  Intron

<220>
<221>  misc_feature
<222>  (3202)..(4275)
<223>  G6PC coding sequence

<220>
<221>  misc_feature
<222>  (4508)..(4653)
<223>  Inverted terminal repeat

<400>  2
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

ccctttgaga atccacggtg tctcgatgca gtcagctttc taacaagctg gggcctcacc      240

tgttttccca cggataaaaa cgtgctggag gaagcagaaa ggggctggca ggtggaaaga      300

tgaggaccag ctcatcgtct catgactatg aggttgctct gatccagagg gtccccctgc      360

ctggtggccc accgccagga agactcccac tgtccctgga tgcccagagt gggatgtcaa      420

ctccatcact tatcaactcc ttatccatag gggtattctt cctgaggcgt ctcagaaaac      480

agggccctcc ccatatgctg accacataat agaacccctc ccaactcaga gaccctggct      540

gctagctgcc ctggcatgac ccagacagtg gcctttgtat atgtttttag actcaccttg      600

actcacctct gaccatagaa actctcatcc cagaggtcac tgcaatagtt actccacaac      660

agaggcttat ctgggtagag ggaggctccc tacctatggc ccagcagccc tgacagtgca      720

gatcacatat accccacgcc ccagcactgc ctgccacgca tgggcttact ttacacccac      780

ccacagtcac caacacatta cctgctctcc aaggttaggc gtggcaggag aagtttgctt      840

ggaccagcag aaaccatgca gtcaaggaca actggagtca gcatgggctg ggtgcgagcc      900

cttggtgggg tggggaggag actccaggtc atacctcctg gaggatgttt taatcatttc      960

cagcatggaa tgctgtcaac ttttgccaca gattcattag ctctgagttt cttttttctg     1020

tccccagcta ccccttacat gtcaatatgg acttaatgat gggaaattca ggcaagtttt     1080

taaacatttt attccccctg gctcttatcc tcaaaaaatg catgaatttg gaggcagtgg     1140

ctcatgcctg taatcccaat gctttgctag gttgaggcgg gaggatcact tgaagccagg     1200

aatttgagac cagcctgggc cgcatagtga gaccccgttt ctacaaaaat aaataaataa     1260

ataataaata atagtgatat gaagcatgat taaatagccc tattttttaa aatgcatgag     1320

ttcgttacct gattcattcc ctggttcctt tcacagtcct ccgtgaccca agtgttaggg     1380

ttttggtctc tctactattt gtaggctgat atatagtata cacacacaca cacacacaca     1440

tatacacaca cacagtgtat cttgagcttt cttttgtata tctacacaca tatgtataag     1500

aaagctcaag atatagaagc cctttttcaa aaataactga aagtttcaaa ctctttaagt     1560

ctccagttac cattttgctg gtattcttat ttggaaccat acattcatca tattgttgca     1620

cagtaagact atacattcat tattttgctt aaacgtatga gttaaaacac ttggccaggc     1680

atggtggttc acacctgtaa tcccagagct ttgggaagcc aagactggca gatctcttga     1740

gctcaggaat tcaagaccag cctgggcaac atggaaaaac cccatctcta caaaagatag     1800

aaaaattagc caggcatggt ggcgtgtgcc tgtggtccca gctactcagg aggctgaggt     1860

gggaggatca cattagccca ggaggttgag gctgcagtga gccgtgatta tgccactgca     1920

ctccagcctg ggagacagag tgagaccctg tttcaaaaaa aagagagaga aaatttaaaa     1980

aagaaaacaa caccaagggc tgtaacttta aggtcattaa atgaattaat cactgcattc     2040

aaaaacgatt actttctggc cctaagagac atgaggccaa taccaggaag ggggttgatc     2100

tcccaaacca gaggcagacc ctagactcta atacagttaa ggaaagacca gcaagatgat     2160

agtccccaat acaatagaag ttactatatt ttatttgttg tttttctttt gttttgtttt     2220

gttttgtttt gttttgtttt agagactggg gtcttgctcg attgcccagg ctgtagtgca     2280

gcggtgggac aatagctcac tgcagactcc aactcctggg ctcaagcaat cctcctgcct     2340

cagcctcctg aatagctggg actacaaggg tacaccatca cacacaccaa aacaattttt     2400

taaatttttg tgtagaaacg agggtcttgc tttgttgccc aggctggtct ccaactcctg     2460

gcttcaaggg atcctcccac ctcagcctcc caaattgctg ggattacagg tgtgagccac     2520

cacaaccagc cagaacttta ctaattttaa aattaagaac ttaaaacttg aatagctaga     2580

gcaccaagat ttttctttgt ccccaaataa gtgcagttgc aggcatagaa aatctgacat     2640

ctttgcaaga atcatcgtgg atgtagactc tgtcctgtgt ctctggcctg gtttcgggga     2700

ccaggagggc agacccttgc actgccaaga agcatgccaa agttaatcat tggccctgct     2760

gagtacatgg ccgatcaggc tgtttttgtg tgcctgtttt tctattttac gtaaatcacc     2820

ctgaacatgt ttgcatcaac ctactggtga tgcacctttg atcaatacat tttagacaaa     2880

cgtggttttt gagtccaaag atcagggctg ggttgacctg aatactggat acagggcata     2940

taaaacaggg gcaaggcaca gactcatagc agagcaatca ccaccaagcc tggaataact     3000

gcaagggctc tgctgacatc ttcctgaggt gccaaggaaa tgaggtctag taggtaagta     3060

tcaaggttac aagacaggtt taaggagacc aatagaaact gggcttgtcg agacagagaa     3120

gactcttgcg tttctgatag gcacctattg gtcttactga catccacttt gcctttctct     3180

ccacaggtcc tgcaggccac catggaggaa ggaatgaatg ttctccatga ctttgggatc     3240

cagtcaacac attacctcca ggtgaattac caagactccc aggactggtt catcttggtg     3300

tccgtgatcg cagacctcag gaatgccttc tacgtcctct tccccatctg gttccatctt     3360

caggaagctg tgggcattaa actcctttgg gtagctgtga ttggagactg gctcaacctc     3420

gtctttaagt ggattctctt tggacagcgt ccatactggt gggttttgga tactgactac     3480

tacagcaaca cttccgtgcc cctgataaag cagttccctg taacctgtga gactggacca     3540

gggagcccct ctggccatgc catgggcaca gcaggtgtat actacgtgat ggtcacatct     3600

actctttcca tctttcaggg aaagataaag ccgacctaca gatttcggtg cttgaatgtc     3660

attttgtggt tgggattctg ggctgtgcag ctgaatgtct gtctgtcacg aatctacctt     3720

gctgctcatt ttcctcatca agttgttgct ggagtcctgt caggcattgc tgttgcagaa     3780

actttcagcc acatccacag catctataat gccagcctca agaaatattt tctcattacc     3840

ttcttcctgt tcagcttcgc catcggattt tatctgctgc tcaagggact gggtgtagac     3900

ctcctgtgga ctctggagaa agcccagagg tggtgcgagc agccagaatg ggtccacatt     3960

gacaccacac cctttgccag cctcctcaag aacctgggca cgctctttgg cctggggctg     4020

gctctcaact ccagcatgta cagggagagc tgcaagggga aactcagcaa gtggctccca     4080

ttccgcctca gctctattgt agcctccctc gtcctcctgc acgtctttga ctccttgaaa     4140

cccccatccc aagtcgagct ggtcttctac gtcttgtcct tctgcaagag tgcggtagtg     4200

cccctggcat ccgtcagtgt catcccctac tgcctcgccc aggtcctggg ccagccgcac     4260

aagaagtcgt tgtaagcggc cgcggggatc cagacatgat aagatacatt gatgagtttg     4320

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     4380

ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc     4440

attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttagtcgacc atgctgggga     4500

gagatctagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     4560

actgaggccg cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc ggcctcagtg     4620

agcgagcgag cgcgcagaga gggagtggcc aacccccccc cccccccccc tgcagccctg     4680

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     4740

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     4800

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     4860

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     4920

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     4980

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     5040

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     5100

ctttctcaat gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     5160

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     5220

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     5280

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     5340

ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     5400

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     5460

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     5520

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     5580

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     5640

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     5700

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     5760

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     5820

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     5880

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     5940

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     6000

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     6060

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     6120

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     6180

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     6240

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     6300

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     6360

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     6420

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     6480

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     6540

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     6600

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     6660

cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg     6720

aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa acctctgaca catgcagctc     6780

ccggagacgg tcacagcttg tctgtaagcg gatgccggga gcagacaagc ccgtcagggc     6840

gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact atgcggcatc agagcagatt     6900

gtactgagag tgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac     6960

cgcatcagga aattgtaaac gttaatattt tgttaaaatt cgcgttaaat ttttgttaaa     7020

tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat cccttataaa tcaaaagaat     7080

agaccgagat agggttgagt gttgttccag tttggaacaa gagtccacta ttaaagaacg     7140

tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg cgatggccca ctacgtgaac     7200

catcacccta atcaagtttt ttggggtcga ggtgccgtaa agcactaaat cggaacccta     7260

aagggagccc ccgatttaga gcttgacggg gaaagccggc gaacgtggcg agaaaggaag     7320

ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag tgtagcggtc acgctgcgcg     7380

taaccaccac acccgccgcg cttaatgcgc cgctacaggg cgcgtcgcgc cattcgccat     7440

tcaggctacg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagg     7500

ctgca                                                                 7505


<210>  3
<211>  7671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (plasmid UF11-GPE-co-G6PC)


<220>
<221>  misc_feature
<222>  (17)..(163)
<223>  Inverted terminal repeat

<220>
<221>  misc_feature
<222>  (182)..(3045)
<223>  G6PC promoter/enhancer

<220>
<221>  misc_feature
<222>  (3051)..(3184)
<223>  Stuffer sequence

<220>
<221>  misc_feature
<222>  (3185)..(3321)
<223>  Intron

<220>
<221>  misc_feature
<222>  (3322)..(3367)
<223>  Stuffer sequence

<220>
<221>  misc_feature
<222>  (3368)..(4441)
<223>  Codon optimized G6PC coding sequence

<220>
<221>  misc_feature
<222>  (4674)..(4819)
<223>  Inverted terminal repeat

<400>  3
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

ccctttgaga atccacggtg tctcgatgca gtcagctttc taacaagctg gggcctcacc      240

tgttttccca cggataaaaa cgtgctggag gaagcagaaa ggggctggca ggtggaaaga      300

tgaggaccag ctcatcgtct catgactatg aggttgctct gatccagagg gtccccctgc      360

ctggtggccc accgccagga agactcccac tgtccctgga tgcccagagt gggatgtcaa      420

ctccatcact tatcaactcc ttatccatag gggtattctt cctgaggcgt ctcagaaaac      480

agggccctcc ccatatgctg accacataat agaacccctc ccaactcaga gaccctggct      540

gctagctgcc ctggcatgac ccagacagtg gcctttgtat atgtttttag actcaccttg      600

actcacctct gaccatagaa actctcatcc cagaggtcac tgcaatagtt actccacaac      660

agaggcttat ctgggtagag ggaggctccc tacctatggc ccagcagccc tgacagtgca      720

gatcacatat accccacgcc ccagcactgc ctgccacgca tgggcttact ttacacccac      780

ccacagtcac caacacatta cctgctctcc aaggttaggc gtggcaggag aagtttgctt      840

ggaccagcag aaaccatgca gtcaaggaca actggagtca gcatgggctg ggtgcgagcc      900

cttggtgggg tggggaggag actccaggtc atacctcctg gaggatgttt taatcatttc      960

cagcatggaa tgctgtcaac ttttgccaca gattcattag ctctgagttt cttttttctg     1020

tccccagcta ccccttacat gtcaatatgg acttaatgat gggaaattca ggcaagtttt     1080

taaacatttt attccccctg gctcttatcc tcaaaaaatg catgaatttg gaggcagtgg     1140

ctcatgcctg taatcccaat gctttgctag gttgaggcgg gaggatcact tgaagccagg     1200

aatttgagac cagcctgggc cgcatagtga gaccccgttt ctacaaaaat aaataaataa     1260

ataataaata atagtgatat gaagcatgat taaatagccc tattttttaa aatgcatgag     1320

ttcgttacct gattcattcc ctggttcctt tcacagtcct ccgtgaccca agtgttaggg     1380

ttttggtctc tctactattt gtaggctgat atatagtata cacacacaca cacacacaca     1440

tatacacaca cacagtgtat cttgagcttt cttttgtata tctacacaca tatgtataag     1500

aaagctcaag atatagaagc cctttttcaa aaataactga aagtttcaaa ctctttaagt     1560

ctccagttac cattttgctg gtattcttat ttggaaccat acattcatca tattgttgca     1620

cagtaagact atacattcat tattttgctt aaacgtatga gttaaaacac ttggccaggc     1680

atggtggttc acacctgtaa tcccagagct ttgggaagcc aagactggca gatctcttga     1740

gctcaggaat tcaagaccag cctgggcaac atggaaaaac cccatctcta caaaagatag     1800

aaaaattagc caggcatggt ggcgtgtgcc tgtggtccca gctactcagg aggctgaggt     1860

gggaggatca cattagccca ggaggttgag gctgcagtga gccgtgatta tgccactgca     1920

ctccagcctg ggagacagag tgagaccctg tttcaaaaaa aagagagaga aaatttaaaa     1980

aagaaaacaa caccaagggc tgtaacttta aggtcattaa atgaattaat cactgcattc     2040

aaaaacgatt actttctggc cctaagagac atgaggccaa taccaggaag ggggttgatc     2100

tcccaaacca gaggcagacc ctagactcta atacagttaa ggaaagacca gcaagatgat     2160

agtccccaat acaatagaag ttactatatt ttatttgttg tttttctttt gttttgtttt     2220

gttttgtttt gttttgtttt agagactggg gtcttgctcg attgcccagg ctgtagtgca     2280

gcggtgggac aatagctcac tgcagactcc aactcctggg ctcaagcaat cctcctgcct     2340

cagcctcctg aatagctggg actacaaggg tacaccatca cacacaccaa aacaattttt     2400

taaatttttg tgtagaaacg agggtcttgc tttgttgccc aggctggtct ccaactcctg     2460

gcttcaaggg atcctcccac ctcagcctcc caaattgctg ggattacagg tgtgagccac     2520

cacaaccagc cagaacttta ctaattttaa aattaagaac ttaaaacttg aatagctaga     2580

gcaccaagat ttttctttgt ccccaaataa gtgcagttgc aggcatagaa aatctgacat     2640

ctttgcaaga atcatcgtgg atgtagactc tgtcctgtgt ctctggcctg gtttcgggga     2700

ccaggagggc agacccttgc actgccaaga agcatgccaa agttaatcat tggccctgct     2760

gagtacatgg ccgatcaggc tgtttttgtg tgcctgtttt tctattttac gtaaatcacc     2820

ctgaacatgt ttgcatcaac ctactggtga tgcacctttg atcaatacat tttagacaaa     2880

cgtggttttt gagtccaaag atcagggctg ggttgacctg aatactggat acagggcata     2940

taaaacaggg gcaaggcaca gactcatagc agagcaatca ccaccaagcc tggaataact     3000

gcaagggctc tgctgacatc ttcctgaggt gccaaggaaa tgaggtctag agaagcttta     3060

ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac acaacagtct     3120

cgaacttaag ctgcagtgac tctcttaagg tagccttgca gaagttggtc gtgaggcact     3180

gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa actgggcttg     3240

tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac tgacatccac     3300

tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta aggccctgca     3360

ggccaccatg gaagagggca tgaacgtgct gcacgacttc ggcatccaga gcacccacta     3420

tctgcaggtc aactaccagg acagccagga ctggttcatc ctggtgtccg tgatcgccga     3480

cctgcggaac gccttctacg tgctgttccc catctggttc catctgcaag aagccgtcgg     3540

catcaagctg ctgtgggtgg ccgtgatcgg cgattggctg aacctggtgt tcaagtggat     3600

cctgttcggc cagcggccct attggtgggt gctggacacc gactactaca gcaacaccag     3660

cgtgcccctg atcaagcagt tccccgtgac ctgcgagaca ggccctggct ctccttctgg     3720

ccacgccatg ggaacagccg gcgtgtacta cgtgatggtc accagcaccc tgagcatctt     3780

ccagggcaag atcaagccca cctaccggtt ccggtgcctg aacgtgatcc tgtggctggg     3840

cttctgggcc gtgcagctga acgtgtgcct gagccggatc tacctggccg cccacttccc     3900

acatcaagtg gtggccggcg tgctgagcgg aatcgccgtg gccgagacat tcagccacat     3960

ccacagcatc tacaacgcca gcctgaagaa gtacttcctg atcacattct ttctgttcag     4020

cttcgccatc ggcttctacc tgctgctgaa gggcctgggc gtggacctgc tgtggaccct     4080

ggaaaaggcc cagcggtggt gcgagcagcc cgagtgggtg cacatcgaca ccaccccctt     4140

cgccagcctg ctgaagaacc tgggcaccct gtttggactg ggcctggccc tgaacagcag     4200

catgtacaga gagagctgca agggcaagct gagcaagtgg ctgcccttcc ggctgagcag     4260

catcgtggcc agcctggtgc tgctgcacgt gttcgacagc ctgaagcccc ccagccaggt     4320

ggaactggtg ttttacgtgc tgagcttctg caagagcgcc gtggtgcccc tggcctccgt     4380

gtctgtgatc ccctactgcc tggctcaggt gctgggccag ccccacaaga agtccctctg     4440

agcggccgcg gggatccaga catgataaga tacattgatg agtttggaca aaccacaact     4500

agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta     4560

accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag     4620

gttcaggggg aggtgtggga ggttttttag tcgaccatgc tggggagaga tctaggaacc     4680

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgcccg     4740

ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg     4800

cagagaggga gtggccaacc cccccccccc cccccctgca gccctgcatt aatgaatcgg     4860

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga     4920

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     4980

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     5040

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     5100

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     5160

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     5220

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc     5280

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     5340

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     5400

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     5460

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     5520

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     5580

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     5640

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     5700

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     5760

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     5820

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg     5880

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga     5940

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc     6000

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac     6060

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc     6120

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc     6180

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc     6240

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt     6300

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc     6360

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg     6420

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag     6480

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat     6540

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc     6600

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa     6660

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta     6720

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     6780

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga     6840

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct     6900

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac     6960

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt     7020

tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca     7080

ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggaaatt     7140

gtaaacgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt     7200

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg     7260

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc     7320

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca     7380

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga     7440

tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa     7500

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc     7560

gccgcgctta atgcgccgct acagggcgcg tcgcgccatt cgccattcag gctacgcaac     7620

tgttgggaag ggcgatcggt gcgggcctct tcgctattac gccaggctgc a              7671


<210>  4
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Glu Gly Met Asn Val Leu His Asp Phe Gly Ile Gln Ser Thr 
1               5                   10                  15      


His Tyr Leu Gln Val Asn Tyr Gln Asp Ser Gln Asp Trp Phe Ile Leu 
            20                  25                  30          


Val Ser Val Ile Ala Asp Leu Arg Asn Ala Phe Tyr Val Leu Phe Pro 
        35                  40                  45              


Ile Trp Phe His Leu Gln Glu Ala Val Gly Ile Lys Leu Leu Trp Val 
    50                  55                  60                  


Ala Val Ile Gly Asp Trp Leu Asn Leu Val Phe Lys Trp Ile Leu Phe 
65                  70                  75                  80  


Gly Gln Arg Pro Tyr Trp Trp Val Leu Asp Thr Asp Tyr Tyr Ser Asn 
                85                  90                  95      


Thr Ser Val Pro Leu Ile Lys Gln Phe Pro Val Thr Cys Glu Thr Gly 
            100                 105                 110         


Pro Gly Ser Pro Ser Gly His Ala Met Gly Thr Ala Gly Val Tyr Tyr 
        115                 120                 125             


Val Met Val Thr Ser Thr Leu Ser Ile Phe Gln Gly Lys Ile Lys Pro 
    130                 135                 140                 


Thr Tyr Arg Phe Arg Cys Leu Asn Val Ile Leu Trp Leu Gly Phe Trp 
145                 150                 155                 160 


Ala Val Gln Leu Asn Val Cys Leu Ser Arg Ile Tyr Leu Ala Ala His 
                165                 170                 175     


Phe Pro His Gln Val Val Ala Gly Val Leu Ser Gly Ile Ala Val Ala 
            180                 185                 190         


Glu Thr Phe Ser His Ile His Ser Ile Tyr Asn Ala Ser Leu Lys Lys 
        195                 200                 205             


Tyr Phe Leu Ile Thr Phe Phe Leu Phe Ser Phe Ala Ile Gly Phe Tyr 
    210                 215                 220                 


Leu Leu Leu Lys Gly Leu Gly Val Asp Leu Leu Trp Thr Leu Glu Lys 
225                 230                 235                 240 


Ala Gln Arg Trp Cys Glu Gln Pro Glu Trp Val His Ile Asp Thr Thr 
                245                 250                 255     


Pro Phe Ala Ser Leu Leu Lys Asn Leu Gly Thr Leu Phe Gly Leu Gly 
            260                 265                 270         


Leu Ala Leu Asn Ser Ser Met Tyr Arg Glu Ser Cys Lys Gly Lys Leu 
        275                 280                 285             


Ser Lys Trp Leu Pro Phe Arg Leu Ser Ser Ile Val Ala Ser Leu Val 
    290                 295                 300                 


Leu Leu His Val Phe Asp Ser Leu Lys Pro Pro Ser Gln Val Glu Leu 
305                 310                 315                 320 


Val Phe Tyr Val Leu Ser Phe Cys Lys Ser Ala Val Val Pro Leu Ala 
                325                 330                 335     


Ser Val Ser Val Ile Pro Tyr Cys Leu Ala Gln Val Leu Gly Gln Pro 
            340                 345                 350         


His Lys Lys Ser Leu 
        355         


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
cctttgagaa tccacggtgt                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
cctcatttcc ttggcacctc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
aggtaagtat caaggttaca                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
acctgtggag agaaaggcaa                                                   20


<210>  9
<211>  1074
<212>  DNA
<213>  Canis familiaris familiaris

<400>  9
atggagaaag gaatggatgt gctccatgac tttggaatcc agtcaacgca ctacctccag       60

gtgaattacc aggactctca ggattggttc atcttggtgt ccgtgattgc agacctcagg      120

aatgccttct atgtcctctt tcccatctgg ttccatctgc gtgaagctgt gggcatcaaa      180

cttctctggg tagctgtgat tggagactgg ctcaacctcg tctttaaatg gattctgttt      240

ggacagcgtc catactggtg ggtcatggac accgactact atagcaacac ctctgtgcca      300

ctgataaagc aatttccagt tacctgtgaa actggaccag ggagtccctc tggtcatgcc      360

atgggtacag caggtgtata ctacgtgatg gtcacatcta ccctttctat ctttcggggg      420

agaaaaaggc caacctacag atttcggtgc ttgaatatcc ttctgtggtt gggattctgg      480

gctgtgcagc tgaacgtctg tctgtcccga atctaccttg ctgctcattt cccccatcag      540

gttgttgctg gagtcctgtc aggcattgct gttgctgaaa ctttccgcca catccagagc      600

atctacaatg ccagcctcaa gaaatatttt ctcattactt tcttcctgtt cagttttgcc      660

attggatttt acctgctgct caaggggctg ggtgtggacc tcctgtggac actggaaaaa      720

gccaggagat ggtgtgagcg gccggaatgg gttcacattg acaccacacc ctttgccagc      780

cttctcaaga acgtggggac cctctttggc ctgggggtga ctctcaactc cagcatgtac      840

agggaaagct gcaagggcaa gcttagcaag tggttcccat tccgcctcag ctgcattgtg      900

gtgtctctca tcctcctgca cctctttgac tctttgaaac ccccatccca aactgagctg      960

atcttctaca ccttgtcctt ctgcaagagt gcagcagtgc ccctggcatc tgtcagcctc     1020

atcccctact gccttgcccg ggtcttcgac cagccagaca agaagtcttt gtaa           1074


<210>  10
<211>  357
<212>  PRT
<213>  Canis lupus familiaris

<400>  10

Met Glu Lys Gly Met Asp Val Leu His Asp Phe Gly Ile Gln Ser Thr 
1               5                   10                  15      


His Tyr Leu Gln Val Asn Tyr Gln Asp Ser Gln Asp Trp Phe Ile Leu 
            20                  25                  30          


Val Ser Val Ile Ala Asp Leu Arg Asn Ala Phe Tyr Val Leu Phe Pro 
        35                  40                  45              


Ile Trp Phe His Leu Arg Glu Ala Val Gly Ile Lys Leu Leu Trp Val 
    50                  55                  60                  


Ala Val Ile Gly Asp Trp Leu Asn Leu Val Phe Lys Trp Ile Leu Phe 
65                  70                  75                  80  


Gly Gln Arg Pro Tyr Trp Trp Val Met Asp Thr Asp Tyr Tyr Ser Asn 
                85                  90                  95      


Thr Ser Val Pro Leu Ile Lys Gln Phe Pro Val Thr Cys Glu Thr Gly 
            100                 105                 110         


Pro Gly Ser Pro Ser Gly His Ala Met Gly Thr Ala Gly Val Tyr Tyr 
        115                 120                 125             


Val Met Val Thr Ser Thr Leu Ser Ile Phe Arg Gly Arg Lys Arg Pro 
    130                 135                 140                 


Thr Tyr Arg Phe Arg Cys Leu Asn Ile Leu Leu Trp Leu Gly Phe Trp 
145                 150                 155                 160 


Ala Val Gln Leu Asn Val Cys Leu Ser Arg Ile Tyr Leu Ala Ala His 
                165                 170                 175     


Phe Pro His Gln Val Val Ala Gly Val Leu Ser Gly Ile Ala Val Ala 
            180                 185                 190         


Glu Thr Phe Arg His Ile Gln Ser Ile Tyr Asn Ala Ser Leu Lys Lys 
        195                 200                 205             


Tyr Phe Leu Ile Thr Phe Phe Leu Phe Ser Phe Ala Ile Gly Phe Tyr 
    210                 215                 220                 


Leu Leu Leu Lys Gly Leu Gly Val Asp Leu Leu Trp Thr Leu Glu Lys 
225                 230                 235                 240 


Ala Arg Arg Trp Cys Glu Arg Pro Glu Trp Val His Ile Asp Thr Thr 
                245                 250                 255     


Pro Phe Ala Ser Leu Leu Lys Asn Val Gly Thr Leu Phe Gly Leu Gly 
            260                 265                 270         


Val Thr Leu Asn Ser Ser Met Tyr Arg Glu Ser Cys Lys Gly Lys Leu 
        275                 280                 285             


Ser Lys Trp Phe Pro Phe Arg Leu Ser Cys Ile Val Val Ser Leu Ile 
    290                 295                 300                 


Leu Leu His Leu Phe Asp Ser Leu Lys Pro Pro Ser Gln Thr Glu Leu 
305                 310                 315                 320 


Ile Phe Tyr Thr Leu Ser Phe Cys Lys Ser Ala Ala Val Pro Leu Ala 
                325                 330                 335     


Ser Val Ser Leu Ile Pro Tyr Cys Leu Ala Arg Val Phe Asp Gln Pro 
            340                 345                 350         


Asp Lys Lys Ser Leu 
        355         


