                         SEQUENCE LISTING

<110>  Consejo Nacional de Investigaciones Cientificas y Tecnicas
       Fundacion Sales
       Inis Biotech LLC
       Cerliani, Juan P
       Croci, Diego P
       Cerliani, Juan P
       Salatino, Mariana P
 
<120>  Methods for Modulating Angiogenesis of Cancers Refractory to 
       Anti-VEGF Treatment

<130>  33858-0015

<150>  61/909,942
<151>  2013-11-27

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  408
<212>  DNA
<213>  Human

<400>  1
atggcttgtg gtctggtcgc cagcaacctg aatctcaaac ctggagagtg ccttcgagtg       60

cgaggcgagg tggctcctga cgctaagagc ttcgtgctga acctgggcaa agacagcaac      120

aacctgtgcc tgcacttcaa ccctcgcttc aacgcccacg gcgacgccaa caccatcgtg      180

tgcaacagca aggacggcgg ggcctggggg accgagcagc gggaggctgt ctttcccttc      240

cagcctggaa gtgttgcaga ggtgtgcatc accttcgacc aggccaacct gaccgtcaag      300

ctgccagatg gatacgaatt caagttcccc aaccgcctca acctggaggc catcaactac      360

atggcagctg acggtgactt caagatcaaa tgtgtggcct ttgactga                   408


<210>  2
<211>  135
<212>  PRT
<213>  Human

<400>  2

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  3
<211>  4071
<212>  DNA
<213>  Human

<400>  3
atgcagagca aggtgctgct ggccgtcgcc ctgtggctct gcgtggagac ccgggccgcc       60

tctgtgggtt tgcctagtgt ttctcttgat ctgcccaggc tcagcataca aaaagacata      120

cttacaatta aggctaatac aactcttcaa attacttgca ggggacagag ggacttggac      180

tggctttggc ccaataatca gagtggcagt gagcaaaggg tggaggtgac tgagtgcagc      240

gatggcctct tctgtaagac actcacaatt ccaaaagtga tcggaaatga cactggagcc      300

tacaagtgct tctaccggga aactgacttg gcctcggtca tttatgtcta tgttcaagat      360

tacagatctc catttattgc ttctgttagt gaccaacatg gagtcgtgta cattactgag      420

aacaaaaaca aaactgtggt gattccatgt ctcgggtcca tttcaaatct caacgtgtca      480

ctttgtgcaa gatacccaga aaagagattt gttcctgatg gtaacagaat ttcctgggac      540

agcaagaagg gctttactat tcccagctac atgatcagct atgctggcat ggtcttctgt      600

gaagcaaaaa ttaatgatga aagttaccag tctattatgt acatagttgt cgttgtaggg      660

tataggattt atgatgtggt tctgagtccg tctcatggaa ttgaactatc tgttggagaa      720

aagcttgtct taaattgtac agcaagaact gaactaaatg tggggattga cttcaactgg      780

gaataccctt cttcgaagca tcagcataag aaacttgtaa accgagacct aaaaacccag      840

tctgggagtg agatgaagaa atttttgagc accttaacta tagatggtgt aacccggagt      900

gaccaaggat tgtacacctg tgcagcatcc agtgggctga tgaccaagaa gaacagcaca      960

tttgtcaggg tccatgaaaa accttttgtt gcttttggaa gtggcatgga atctctggtg     1020

gaagccacgg tgggggagcg tgtcagaatc cctgcgaagt accttggtta cccaccccca     1080

gaaataaaat ggtataaaaa tggaataccc cttgagtcca atcacacaat taaagcgggg     1140

catgtactga cgattatgga agtgagtgaa agagacacag gaaattacac tgtcatcctt     1200

accaatccca tttcaaagga gaagcagagc catgtggtct ctctggttgt gtatgtccca     1260

ccccagattg gtgagaaatc tctaatctct cctgtggatt cctaccagta cggcaccact     1320

caaacgctga catgtacggt ctatgccatt cctcccccgc atcacatcca ctggtattgg     1380

cagttggagg aagagtgcgc caacgagccc agccaagctg tctcagtgac aaacccatac     1440

ccttgtgaag aatggagaag tgtggaggac ttccagggag gaaataaaat tgaagttaat     1500

aaaaatcaat ttgctctaat tgaaggaaaa aacaaaactg taagtaccct tgttatccaa     1560

gcggcaaatg tgtcagcttt gtacaaatgt gaagcggtca acaaagtcgg gagaggagag     1620

agggtgatct ccttccacgt gaccaggggt cctgaaatta ctttgcaacc tgacatgcag     1680

cccactgagc aggagagcgt gtctttgtgg tgcactgcag acagatctac gtttgagaac     1740

ctcacatggt acaagcttgg cccacagcct ctgccaatcc atgtgggaga gttgcccaca     1800

cctgtttgca agaacttgga tactctttgg aaattgaatg ccaccatgtt ctctaatagc     1860

acaaatgaca ttttgatcat ggagcttaag aatgcatcct tgcaggacca aggagactat     1920

gtctgccttg ctcaagacag gaagaccaag aaaagacatt gcgtggtcag gcagctcaca     1980

gtcctagagc gtgtggcacc cacgatcaca ggaaacctgg agaatcagac gacaagtatt     2040

ggggaaagca tcgaagtctc atgcacggca tctgggaatc cccctccaca gatcatgtgg     2100

tttaaagata atgagaccct tgtagaagac tcaggcattg tattgaagga tgggaaccgg     2160

aacctcacta tccgcagagt gaggaaggag gacgaaggcc tctacacctg ccaggcatgc     2220

agtgttcttg gctgtgcaaa agtggaggca tttttcataa tagaaggtgc ccaggaaaag     2280

acgaacttgg aaatcattat tctagtaggc acggcggtga ttgccatgtt cttctggcta     2340

cttcttgtca tcatcctacg gaccgttaag cgggccaatg gaggggaact gaagacaggc     2400

tacttgtcca tcgtcatgga tccagatgaa ctcccattgg atgaacattg tgaacgactg     2460

ccttatgatg ccagcaaatg ggaattcccc agagaccggc tgaagctagg taagcctctt     2520

ggccgtggtg cctttggcca agtgattgaa gcagatgcct ttggaattga caagacagca     2580

acttgcagga cagtagcagt caaaatgttg aaagaaggag caacacacag tgagcatcga     2640

gctctcatgt ctgaactcaa gatcctcatt catattggtc accatctcaa tgtggtcaac     2700

cttctaggtg cctgtaccaa gccaggaggg ccactcatgg tgattgtgga attctgcaaa     2760

tttggaaacc tgtccactta cctgaggagc aagagaaatg aatttgtccc ctacaagacc     2820

aaaggggcac gattccgtca agggaaagac tacgttggag caatccctgt ggatctgaaa     2880

cggcgcttgg acagcatcac cagtagccag agctcagcca gctctggatt tgtggaggag     2940

aagtccctca gtgatgtaga agaagaggaa gctcctgaag atctgtataa ggacttcctg     3000

accttggagc atctcatctg ttacagcttc caagtggcta agggcatgga gttcttggca     3060

tcgcgaaagt gtatccacag ggacctggcg gcacgaaata tcctcttatc ggagaagaac     3120

gtggttaaaa tctgtgactt tggcttggcc cgggatattt ataaagatcc agattatgtc     3180

agaaaaggag atgctcgcct ccctttgaaa tggatggccc cagaaacaat ttttgacaga     3240

gtgtacacaa tccagagtga cgtctggtct tttggtgttt tgctgtggga aatattttcc     3300

ttaggtgctt ctccatatcc tggggtaaag attgatgaag aattttgtag gcgattgaaa     3360

gaaggaacta gaatgagggc ccctgattat actacaccag aaatgtacca gaccatgctg     3420

gactgctggc acggggagcc cagtcagaga cccacgtttt cagagttggt ggaacatttg     3480

ggaaatctct tgcaagctaa tgctcagcag gatggcaaag actacattgt tcttccgata     3540

tcagagactt tgagcatgga agaggattct ggactctctc tgcctacctc acctgtttcc     3600

tgtatggagg aggaggaagt atgtgacccc aaattccatt atgacaacac agcaggaatc     3660

agtcagtatc tgcagaacag taagcgaaag agccggcctg tgagtgtaaa aacatttgaa     3720

gatatcccgt tagaagaacc agaagtaaaa gtaatcccag atgacaacca gacggacagt     3780

ggtatggttc ttgcctcaga agagctgaaa actttggaag acagaaccaa attatctcca     3840

tcttttggtg gaatggtgcc cagcaaaagc agggagtctg tggcatctga aggctcaaac     3900

cagacaagcg gctaccagtc cggatatcac tccgatgaca cagacaccac cgtgtactcc     3960

agtgaggaag cagaactttt aaagctgata gagattggag tgcaaaccgg tagcacagcc     4020

cagattctcc agcctgactc ggggaccaca ctgagctctc ctcctgttta a              4071


<210>  4
<211>  1356
<212>  PRT
<213>  Human

<400>  4

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Tyr Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Tyr Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Tyr Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  5
<211>  354
<212>  DNA
<213>  Anti-human

<400>  5
gaggttcagc tgcagcagtc tgtggcagag tttgtgaggc caggggcctc agtcaggttg       60

tcctgcacag cttctggctt caacattaaa aacacctata tacactgggt gaggcagagg      120

cctgaacagg gcctggagtg gattggaaag attgatcctg cgaatggtaa tactaaatat      180

gtcccggagt tccagggcaa ggccactatg actgcggaca catcctccaa cacagtctac      240

ctgcacctca gcagcctgac atctgaggac actgccatct attactgtgt cgatggttac      300

tacggctggt atttcgctgt ctggggcaca gggaccacgg tcaccgtctc ctca            354


<210>  6
<211>  118
<212>  PRT
<213>  Anti-human

<400>  6

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Phe Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Glu Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Asp Gly Tyr Tyr Gly Trp Tyr Phe Ala Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  7
<211>  5
<212>  PRT
<213>  Anti-human

<400>  7

Asn Thr Tyr Ile His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Anti-human

<400>  8

Lys Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Val Pro Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  9
<212>  PRT
<213>  Anti-human

<400>  9

Gly Tyr Tyr Gly Trp Tyr Phe Ala Val 
1               5                   


<210>  10
<211>  327
<212>  DNA
<213>  Anti-human

<400>  10
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagcactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtgctacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg tcctcaccat cacaggggca      240

caaactgagg atgaggcaat atatttctgt gctctatggt acagaaacca ttttattttc      300

ggcagtggaa ccaaggtcac tgtcctc                                          327


<210>  11
<211>  109
<212>  PRT
<213>  Anti-human

<400>  11

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Val Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Arg Asn 
                85                  90                  95      


His Phe Ile Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  12
<211>  14
<212>  PRT
<213>  Anti-human

<400>  12

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  13
<211>  7
<212>  PRT
<213>  Anti-human

<400>  13

Ala Thr Asn Asn Arg Ala Pro 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Anti-human

<400>  14

Ala Leu Trp Tyr Arg Asn His Phe Ile 
1               5                   


