                         SEQUENCE LISTING

<110>  Albert-Ludwigs-Universitaet Freiburg
 
<120>  Reversible PEGylation of nanocarriers

<130>  P44771WO

<160>  19    

<170>  PatentIn version 3.5



<210>  1
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-domain

<400>  1

Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
1               5                   10                  15      


Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
            20                  25                  30          


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
    50                  55                  60                  


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
65                  70                  75                  80  


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
                85                  90                  95      


Asp Trp Met Ser Gly Lys Ala Phe Ala Cys Ala Val Asn Asn Lys Asp 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
        115                 120                 125             


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
    130                 135                 140                 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
145                 150                 155                 160 


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
                165                 170                 175     


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
            180                 185                 190         


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
        195                 200                 205             


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
    210                 215                 220                 


Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230         



<210>  2
<211>  220
<212>  PRT
<213>  GyrB

<400>  2

Met Ser Asn Ser Tyr Asp Ser Ser Ser Ile Lys Val Leu Lys Gly Leu 
1               5                   10                  15      


Asp Ala Val Arg Lys Arg Pro Gly Met Tyr Ile Gly Asp Thr Asp Asp 
            20                  25                  30          


Gly Thr Gly Leu His His Met Val Phe Glu Val Val Asp Asn Ala Ile 
        35                  40                  45              


Asp Glu Ala Leu Ala Gly His Cys Lys Glu Ile Ile Val Thr Ile His 
    50                  55                  60                  


Ala Asp Asn Ser Val Ser Val Gln Asp Asp Gly Arg Gly Ile Pro Thr 
65                  70                  75                  80  


Gly Ile His Pro Glu Glu Gly Val Ser Ala Ala Glu Val Ile Met Thr 
                85                  90                  95      


Val Leu His Ala Gly Gly Lys Phe Asp Asp Asn Ser Tyr Lys Val Ser 
            100                 105                 110         


Gly Gly Leu His Gly Val Gly Val Ser Val Val Asn Ala Leu Ser Gln 
        115                 120                 125             


Lys Leu Glu Leu Val Ile Gln Arg Glu Gly Lys Ile His Arg Gln Ile 
    130                 135                 140                 


Tyr Glu His Gly Val Pro Gln Ala Pro Leu Ala Val Thr Gly Glu Thr 
145                 150                 155                 160 


Glu Lys Thr Gly Thr Met Val Arg Phe Trp Pro Ser Leu Glu Thr Phe 
                165                 170                 175     


Thr Asn Val Thr Glu Phe Glu Tyr Glu Ile Leu Ala Lys Arg Leu Arg 
            180                 185                 190         


Glu Leu Ser Phe Leu Asn Ser Gly Val Ser Ile Arg Leu Arg Asp Lys 
        195                 200                 205             


Arg Asp Gly Lys Glu Asp His Phe His Tyr Glu Gly 
    210                 215                 220 



<210>  3
<211>  660
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<223>  Nucleotide sequence encoding GyrB

<400>  3
atgtcgaatt cttatgactc ctccagtatc aaagtcctga aagggctgga tgcggtgcgt       60

aagcgcccgg gtatgtatat cggcgacacg gatgacggca ccggtctgca ccacatggta      120

ttcgaggtgg tagataacgc tatcgacgaa gcgctcgcgg gtcactgtaa agaaattatc      180

gtcaccattc acgccgataa ctctgtctct gtacaggatg acgggcgcgg cattccgacc      240

ggtattcacc cggaagaggg cgtatcggcg gcggaagtga tcatgaccgt tctgcacgca      300

ggcggtaaat ttgacgataa ctcctataaa gtgtccggcg gtctgcacgg cgttggtgtt      360

tcggtagtaa acgccctgtc gcaaaaactg gagctggtta tccagcgcga gggtaaaatt      420

caccgtcaga tctacgaaca cggtgtaccg caggccccgc tggcggttac cggcgagact      480

gaaaaaaccg gcaccatggt gcgtttctgg cccagcctcg aaaccttcac caatgtgacc      540

gagttcgaat atgaaattct ggcgaaacgt ctgcgtgagt tgtcgttcct caactccggc      600

gtttccattc gtctgcgcga caagcgcgac ggcaaagaag accacttcca ctatgaaggc      660



<210>  4
<211>  522
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of sequence: FluA - flourescein 
       (FluA_A45I_R95K_S114R)

<400>  4
gacgtgtacc acgacggcgc ctgccccgaa gtgaagcccg tggacaactt cgactggtcc       60

cagtaccacg gcaagtggtg ggaggtggcc aagtacccca gccccaacgg caagtatggc      120

aagtgcggct ggattgagta cacccccgag ggcaagagcg tgaaggtgtc cagatacgac      180

gtgatccacg gcaaagaata cttcatggaa ggcaccgcct accccgtggg cgacagcaag      240

atcggcaaga tctaccacag ccggaccgtg ggcggctaca ccaagaagac cgtgttcaac      300

gtgctgtcca ccgacaacaa gaactacatc atcggctacc gctgccgcta cgacgaggac      360

aagaagggcc actgggacca cgtgtgggtg ctgtcccggt ccatggtgct gaccggcgag      420

gccaagaccg ccgtggagaa ctacctgatc ggcagccccg tggtggacag ccagaaactg      480

gtgtacagcg acttcagcga ggccgcctgc aaagtgaaca ac                         522


<210>  5
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of sequence: FluA - flourescein 
       (FluA_A45I_R95K_S114R)

<400>  5

Met Asp Val Tyr His Asp Gly Ala Cys Pro Glu Val Lys Pro Val Asp 
1               5                   10                  15      


Asn Phe Asp Trp Ser Gln Tyr His Gly Lys Trp Trp Glu Val Ala Lys 
            20                  25                  30          


Tyr Pro Ser Pro Asn Gly Lys Tyr Gly Lys Cys Gly Trp Ile Glu Tyr 
        35                  40                  45              


Thr Pro Glu Gly Lys Ser Val Lys Val Ser Arg Tyr Asp Val Ile His 
    50                  55                  60                  


Gly Lys Glu Tyr Phe Met Glu Gly Thr Ala Tyr Pro Val Gly Asp Ser 
65                  70                  75                  80  


Lys Ile Gly Lys Ile Tyr His Ser Arg Thr Val Gly Gly Tyr Thr Lys 
                85                  90                  95      


Lys Thr Val Phe Asn Val Leu Ser Thr Asp Asn Lys Asn Tyr Ile Ile 
            100                 105                 110         


Gly Tyr Arg Cys Arg Tyr Asp Glu Asp Lys Lys Gly His Trp Asp His 
        115                 120                 125             


Val Trp Val Leu Ser Arg Ser Met Val Leu Thr Gly Glu Ala Lys Thr 
    130                 135                 140                 


Ala Val Glu Asn Tyr Leu Ile Gly Ser Pro Val Val Asp Ser Gln Lys 
145                 150                 155                 160 


Leu Val Tyr Ser Asp Phe Ser Glu Ala Ala Cys Lys Val Asn Asn 
                165                 170                 175 


<210>  6
<211>  552
<212>  DNA
<213>  Unknown

<220>
<223>  Description of sequence: DigA_16

<400>  6
gacgtgtacc acgacggcgc ctgccccgaa gtgaagcccg tggacaactt cgactggtcc       60

cagtaccacg gcaagtggtg gcaggtggcc gcttatcccg accacatcac caagtacggc      120

aagtgcggct gggccgagta cacccccgag ggcaagagcg tgaaggtgtc ccggtacagc      180

gtgatccacg gcaaagagta cttcagcgag ggcaccgcct accctgtggg cgacagcaag      240

atcggcaaga tctaccacag ctacaccatc ggcggcgtga cccaggaggg cgtgttcaac      300

gtgctgtcca ccgacaacaa gaactacatc atcggctact tttgcagata cgacgaggac      360

aagaagggcc acatggactt ggtgtgggtg ctgtcccggt ccatggtgct gaccggcgag      420

gccaagaccg ccgtggagaa ctacctgatc ggcagccccg tggtggacag ccagaaactg      480

gtgtacagcg acttctccga ggccgcctgc aaagtgaaca acagcaactg gtcccacccc      540

cagttcgaaa ag                                                          552


<210>  7
<211>  185
<212>  PRT
<213>  Unknown

<220>
<223>  Description of sequence: DigA_16

<400>  7

Met Asp Val Tyr His Asp Gly Ala Cys Pro Glu Val Lys Pro Val Asp 
1               5                   10                  15      


Asn Phe Asp Trp Ser Gln Tyr His Gly Lys Trp Trp Gln Val Ala Ala 
            20                  25                  30          


Tyr Pro Asp His Ile Thr Lys Tyr Gly Lys Cys Gly Trp Ala Glu Tyr 
        35                  40                  45              


Thr Pro Glu Gly Lys Ser Val Lys Val Ser Arg Tyr Ser Val Ile His 
    50                  55                  60                  


Gly Lys Glu Tyr Phe Ser Glu Gly Thr Ala Tyr Pro Val Gly Asp Ser 
65                  70                  75                  80  


Lys Ile Gly Lys Ile Tyr His Ser Tyr Thr Ile Gly Gly Val Thr Gln 
                85                  90                  95      


Glu Gly Val Phe Asn Val Leu Ser Thr Asp Asn Lys Asn Tyr Ile Ile 
            100                 105                 110         


Gly Tyr Phe Cys Ser Tyr Asp Glu Asp Lys Lys Gly His Met Asp Leu 
        115                 120                 125             


Val Trp Val Leu Ser Arg Ser Met Val Leu Thr Gly Glu Ala Lys Thr 
    130                 135                 140                 


Ala Val Glu Asn Tyr Leu Ile Gly Ser Pro Val Val Asp Ser Gln Lys 
145                 150                 155                 160 


Leu Val Tyr Ser Asp Phe Ser Glu Ala Ala Cys Lys Val Asn Asn Ser 
                165                 170                 175     


Asn Trp Ser His Pro Gln Phe Glu Lys 
            180                 185 


<210>  8
<211>  1079
<212>  DNA
<213>  Unknown

<220>
<223>  Description of sequence: Salicyclic Acid Binding Protein 2 
       (SABP2)

<400>  8
acgcggggaa agaaaagaaa ctaacaaggc ataaaattca aatgaaggaa ggaaaacact       60

ttgttttagt acatggtgca tgccatggag gttggagttg gtacaagcta aagccactgc      120

tagaagctgc aggccataag gttacagccc ttgatttagc agcttctggc actgatttga      180

gaaaaataga ggagcttcgc acactttatg attatacttt gccattgatg gagttgatgg      240

aatctctttc agcagatgag aaggttatat tagtggggca tagtcttggt ggtatgaatt      300

tgggacttgc tatggaaaag tatccacaaa agatctatgc tgctgttttc ttggctgctt      360

tcatgcctga ttctgttcac aactcctcct ttgttttgga acagtataat gagcggacgc      420

cagccgagaa ttggttggat actcagtttt taccatatgg ttcccctgaa gagccactga      480

catccatgtt ttttggccca aagttcttgg ctcacaagct ctaccagcta tgctctcctg      540

aggatcttgc attagcatca tcattggtga gaccaagctc tttgtttatg gaagacctat      600

cgaaggccaa gtatttcaca gatgaacggt ttggatcagt gaagagagtt tacattgtgt      660

gcactgagga taaaggcata ccagaagaat tccagcgatg gcaaattgac aacattggtg      720

tcactgaagc aatagagatt aaaggtgctg atcacatggc aatgctatgc gagccccaaa      780

aactttgcgc ctctctcttg gaaattgccc ataaatacaa ctgatctcta cattatgtct      840

tcgtctcatg tcaagatttt cagtgcatgc tgtaattttt ttctattttt cgaccggcgc      900

ataactgtct ttgcctattt taaggattgc agtaatttca ctcttctagt gtggaaggct      960

tccacataag gattgttctg tttctccatt caagtgtgtg ttatgttgag atacttaaac     1020

cgtatcaatt cttgtaatga aacttcttct ttcctttttg aaaaaaaaaa aaaaaaaaa      1079


<210>  9
<211>  260
<212>  PRT
<213>  Unknown

<220>
<223>  Description of sequence: Salicyclic Acid Binding Protein 2 
       (SABP2)

<400>  9

Met Lys Glu Gly Lys His Phe Val Leu Val His Gly Ala Cys His Gly 
1               5                   10                  15      


Gly Trp Ser Trp Tyr Lys Leu Lys Pro Leu Leu Glu Ala Ala Gly His 
            20                  25                  30          


Lys Val Thr Ala Leu Asp Leu Ala Ala Ser Gly Thr Asp Leu Arg Lys 
        35                  40                  45              


Ile Glu Glu Leu Arg Thr Leu Tyr Asp Tyr Thr Leu Pro Leu Met Glu 
    50                  55                  60                  


Leu Met Glu Ser Leu Ser Ala Asp Glu Lys Val Ile Leu Val Gly His 
65                  70                  75                  80  


Ser Leu Gly Gly Met Asn Leu Gly Leu Ala Met Glu Lys Tyr Pro Gln 
                85                  90                  95      


Lys Ile Tyr Ala Ala Val Phe Leu Ala Ala Phe Met Pro Asp Ser Val 
            100                 105                 110         


His Asn Ser Ser Phe Val Leu Glu Gln Tyr Asn Glu Arg Thr Pro Ala 
        115                 120                 125             


Glu Asn Trp Leu Asp Thr Gln Phe Leu Pro Tyr Gly Ser Pro Glu Glu 
    130                 135                 140                 


Pro Leu Thr Ser Met Phe Phe Gly Pro Lys Phe Leu Ala His Lys Leu 
145                 150                 155                 160 


Tyr Gln Leu Cys Ser Pro Glu Asp Leu Ala Leu Ala Ser Ser Leu Val 
                165                 170                 175     


Arg Pro Ser Ser Leu Phe Met Glu Asp Leu Ser Lys Ala Lys Tyr Phe 
            180                 185                 190         


Thr Asp Glu Arg Phe Gly Ser Val Lys Arg Val Tyr Ile Val Cys Thr 
        195                 200                 205             


Glu Asp Lys Gly Ile Pro Glu Glu Phe Gln Arg Trp Gln Ile Asp Asn 
    210                 215                 220                 


Ile Gly Val Thr Glu Ala Ile Glu Ile Lys Gly Ala Asp His Met Ala 
225                 230                 235                 240 


Met Leu Cys Glu Pro Gln Lys Leu Cys Ala Ser Leu Leu Glu Ile Ala 
                245                 250                 255     


His Lys Tyr Asn 
            260 


<210>  10
<211>  1079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of sequence: Salicyclic Acid Binding Protein 2 (SABP2
       S81A)

<400>  10
acgcggggaa agaaaagaaa ctaacaaggc ataaaattca aatgaaggaa ggaaaacact       60

ttgttttagt acatggtgca tgccatggag gttggagttg gtacaagcta aagccactgc      120

tagaagctgc aggccataag gttacagccc ttgatttagc agcttctggc actgatttga      180

gaaaaataga ggagcttcgc acactttatg attatacttt gccattgatg gagttgatgg      240

aagctctttc agcagatgag aaggttatat tagtggggca tagtcttggt ggtatgaatt      300

tgggacttgc tatggaaaag tatccacaaa agatctatgc tgctgttttc ttggctgctt      360

tcatgcctga ttctgttcac aactcctcct ttgttttgga acagtataat gagcggacgc      420

cagccgagaa ttggttggat actcagtttt taccatatgg ttcccctgaa gagccactga      480

catccatgtt ttttggccca aagttcttgg ctcacaagct ctaccagcta tgctctcctg      540

aggatcttgc attagcatca tcattggtga gaccaagctc tttgtttatg gaagacctat      600

cgaaggccaa gtatttcaca gatgaacggt ttggatcagt gaagagagtt tacattgtgt      660

gcactgagga taaaggcata ccagaagaat tccagcgatg gcaaattgac aacattggtg      720

tcactgaagc aatagagatt aaaggtgctg atcacatggc aatgctatgc gagccccaaa      780

aactttgcgc ctctctcttg gaaattgccc ataaatacaa ctgatctcta cattatgtct      840

tcgtctcatg tcaagatttt cagtgcatgc tgtaattttt ttctattttt cgaccggcgc      900

ataactgtct ttgcctattt taaggattgc agtaatttca ctcttctagt gtggaaggct      960

tccacataag gattgttctg tttctccatt caagtgtgtg ttatgttgag atacttaaac     1020

cgtatcaatt cttgtaatga aacttcttct ttcctttttg aaaaaaaaaa aaaaaaaaa      1079


<210>  11
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of sequence: Salicyclic Acid Binding Protein 2 (SABP2
       S81A)

<400>  11

Met Lys Glu Gly Lys His Phe Val Leu Val His Gly Ala Cys His Gly 
1               5                   10                  15      


Gly Trp Ser Trp Tyr Lys Leu Lys Pro Leu Leu Glu Ala Ala Gly His 
            20                  25                  30          


Lys Val Thr Ala Leu Asp Leu Ala Ala Ser Gly Thr Asp Leu Arg Lys 
        35                  40                  45              


Ile Glu Glu Leu Arg Thr Leu Tyr Asp Tyr Thr Leu Pro Leu Met Glu 
    50                  55                  60                  


Leu Met Glu Ser Leu Ser Ala Asp Glu Lys Val Ile Leu Val Gly His 
65                  70                  75                  80  


Ala Leu Gly Gly Met Asn Leu Gly Leu Ala Met Glu Lys Tyr Pro Gln 
                85                  90                  95      


Lys Ile Tyr Ala Ala Val Phe Leu Ala Ala Phe Met Pro Asp Ser Val 
            100                 105                 110         


His Asn Ser Ser Phe Val Leu Glu Gln Tyr Asn Glu Arg Thr Pro Ala 
        115                 120                 125             


Glu Asn Trp Leu Asp Thr Gln Phe Leu Pro Tyr Gly Ser Pro Glu Glu 
    130                 135                 140                 


Pro Leu Thr Ser Met Phe Phe Gly Pro Lys Phe Leu Ala His Lys Leu 
145                 150                 155                 160 


Tyr Gln Leu Cys Ser Pro Glu Asp Leu Ala Leu Ala Ser Ser Leu Val 
                165                 170                 175     


Arg Pro Ser Ser Leu Phe Met Glu Asp Leu Ser Lys Ala Lys Tyr Phe 
            180                 185                 190         


Thr Asp Glu Arg Phe Gly Ser Val Lys Arg Val Tyr Ile Val Cys Thr 
        195                 200                 205             


Glu Asp Lys Gly Ile Pro Glu Glu Phe Gln Arg Trp Gln Ile Asp Asn 
    210                 215                 220                 


Ile Gly Val Thr Glu Ala Ile Glu Ile Lys Gly Ala Asp His Met Ala 
225                 230                 235                 240 


Met Leu Cys Glu Pro Gln Lys Leu Cys Ala Ser Leu Leu Glu Ile Ala 
                245                 250                 255     


His Lys Tyr Asn 
            260 


<210>  12
<211>  1098
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Sequence: Arabidopsis FK506 binding protein 
       (FKBP42)

<400>  12
atggatgaat ctctggagca tcaaactcaa acacatgacc aagagagcga aatagttact       60

gaaggaagtg ccgttgtgca tagtgagcca tctcaagagg gtaatgttcc tcctaaagtt      120

gatagtgaag ctgaggtctt ggatgagaaa gtcagtaagc agattataaa ggaaggtcac      180

ggttccaaac catccaagta ctctacatgc tttttgcact acagggcatg gaccaaaaac      240

tcgcagcaca aatttgagga tacatggcat gagcagcaac ctattgaatt ggttcttgga      300

aaagagaaaa aagaactagc cggtttagcc atcggtgttg ctagcatgaa gtctggtgaa      360

cgtgcgcttg tgcatgttgg ctgggaatta gcttatggga aagaaggaaa cttttctttt      420

ccgaatgttc cacctatggc agacttgtta tatgaggtgg aagttattgg gtttgatgaa      480

acaaaggagg gaaaagctcg cagtgatatg actgtagagg aaaggattgg tgcagcagac      540

agaagaaaaa tggatgggaa ttctcttttt aaggaggaga aactggagga agccatgcaa      600

cagtatgaaa tggccatagc atacatgggg gacgatttta tgtttcagct gtatgggaag      660

taccaggata tggctttagc agttaaaaac ccatgccatc ttaacatagc agcttgcctc      720

atcaaactaa aacgatacga tgaagcaatt ggtcactgca acattgtgtt gacagaagaa      780

gagaaaaacc caaaagcact gttcagaaga gggaaagcaa aggcagagct aggacagatg      840

gactcagcac gtgatgattt ccgaaaggca caaaagtatg ctcctgacga caaggcgatt      900

agaagagagc tacgagcact tgcagagcaa gagaaagcct tgtaccaaaa gcagaaagaa      960

atgtacaaag gaatattcaa agggaaagat gaaggtggtg ctaagtcaaa gagccttttt     1020

tggttgatag tgttatggca atggtttgtt tcccttttct cccgtatctt tcgacgccac     1080

agagttaaag cagattaa                                                   1098


<210>  13
<211>  493
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Sequence: Arabidopsis FK506 binding protein 
       (FKBP42), aa 1-163

<400>  13
atggatgaat ctctggagca tcaaactcaa acacatgacc aagagagcga aatagttact       60

gaaggaagtg ccgttgtgca tagtgagcca tctcaagagg gtaatgttcc tcctaaagtt      120

gatagtgaag ctgaggtctt ggatgagaaa gtcagtaagc agattataaa ggaaggtcac      180

ggttccaaac catccaagta ctctacatgc tttttgcact acagggcatg gaccaaaaac      240

tcgcagcaca aatttgagga tacatggcat gagcagcaac ctattgaatt ggttcttgga      300

aaagagaaaa aagaactagc cggtttagcc atcggtgttg ctagcatgaa gtctggtgaa      360

cgtgcgcttg tgcatgttgg ctgggaatta gcttatggga aagaaggaaa cttttctttt      420

ccgaatgttc cacctatggc agacttgtta tatgaggtgg aagttattgg gtttgatgaa      480

acaaaggagg taa                                                         493


<210>  14
<211>  163
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Sequence: Arabidopsis FK506 binding protein 
       (FKBP42), aa 1-163

<400>  14

Met Asp Glu Ser Leu Glu His Gln Thr Gln Thr His Asp Gln Glu Ser 
1               5                   10                  15      


Glu Ile Val Thr Glu Gly Ser Ala Val Val His Ser Glu Pro Ser Gln 
            20                  25                  30          


Glu Gly Asn Val Pro Pro Lys Val Asp Ser Glu Ala Glu Val Leu Asp 
        35                  40                  45              


Glu Lys Val Ser Lys Gln Ile Ile Lys Glu Gly His Gly Ser Lys Pro 
    50                  55                  60                  


Ser Lys Tyr Ser Thr Cys Phe Leu His Tyr Arg Ala Trp Thr Lys Asn 
65                  70                  75                  80  


Ser Gln His Lys Phe Glu Asp Thr Trp His Glu Gln Gln Pro Ile Glu 
                85                  90                  95      


Leu Val Leu Gly Lys Glu Lys Lys Glu Leu Ala Gly Leu Ala Ile Gly 
            100                 105                 110         


Val Ala Ser Met Lys Ser Gly Glu Arg Ala Leu Val His Val Gly Trp 
        115                 120                 125             


Glu Leu Ala Tyr Gly Lys Glu Gly Asn Phe Ser Phe Pro Asn Val Pro 
    130                 135                 140                 


Pro Met Ala Asp Leu Leu Tyr Glu Val Glu Val Ile Gly Phe Asp Glu 
145                 150                 155                 160 


Thr Lys Glu 
            


<210>  15
<211>  891
<212>  DNA
<213>  Unknown

<220>
<223>  Description of sequence: Arabidopsis multiresistance-like ABC 
       transporter AtPGP1

<400>  15
atgctcagat ccggtctggc ttcgttaatc gtcgatgtca atttgcggcg cacgttacgt       60

ccatccccaa ccttttcttt tccggcgcat cttagccgtt gcattatcac ttcccgttac      120

tcctcccgta catctctaag gtttccgatt caaatatctc gccaccaaca ccgtctatcc      180

tacttttctt catcctcttc gtcggagcaa agcagaccaa cttcctcttc ccgaaacagt      240

ttcagtggtc acggtcagct tgatagtgat gataattctt caccgcctcc gtcgcaatca      300

tcttccaaag ttcttacatt gcctaccgta ttaacacttg gtcgtgtcgc cgccgtcccg      360

cttctcgtcg caacctttta cgttgatagt tggtggggaa caactgctac aacaagcatt      420

ttcattgcag cagccattac agactggctt gacggctatc ttgcccgcaa gatgaggtta      480

ggttctgcgt ttggtgcctt tttggatcca gttgctgata agcttatggt tgcagctaca      540

ttgattttac tgtgtacaaa acctatccaa gttgctgaat taggaccact tccatggtta      600

ttgaccgtac cttctattgc aatcattggt agggagatta ctatgtccgc agtaagagaa      660

tgggctgcat ctcaaaatgg aaagctttta gaggcagttg ctgtaaataa cttgggcaag      720

tggaaaaccg ccacgcagat gacagcacta accatacttc ttgcaagccg agatagcaat      780

gttggatggc tcgtagcttc aggtgctggc ttgctttatg tatcagcagg actatctgtt      840

tggtctttag ccgtttatat gaggaagata tggaaagtac taatgaagta g               891


<210>  16
<211>  296
<212>  PRT
<213>  Unknown

<220>
<223>  Description of sequence: Arabidopsis multiresistance-like ABC 
       transporter AtPGP1

<400>  16

Met Leu Arg Ser Gly Leu Ala Ser Leu Ile Val Asp Val Asn Leu Arg 
1               5                   10                  15      


Arg Thr Leu Arg Pro Ser Pro Thr Phe Ser Phe Pro Ala His Leu Ser 
            20                  25                  30          


Arg Cys Ile Ile Thr Ser Arg Tyr Ser Ser Arg Thr Ser Leu Arg Phe 
        35                  40                  45              


Pro Ile Gln Ile Ser Arg His Gln His Arg Leu Ser Tyr Phe Ser Ser 
    50                  55                  60                  


Ser Ser Ser Ser Glu Gln Ser Arg Pro Thr Ser Ser Ser Arg Asn Ser 
65                  70                  75                  80  


Phe Ser Gly His Gly Gln Leu Asp Ser Asp Asp Asn Ser Ser Pro Pro 
                85                  90                  95      


Pro Ser Gln Ser Ser Ser Lys Val Leu Thr Leu Pro Thr Val Leu Thr 
            100                 105                 110         


Leu Gly Arg Val Ala Ala Val Pro Leu Leu Val Ala Thr Phe Tyr Val 
        115                 120                 125             


Asp Ser Trp Trp Gly Thr Thr Ala Thr Thr Ser Ile Phe Ile Ala Ala 
    130                 135                 140                 


Ala Ile Thr Asp Trp Leu Asp Gly Tyr Leu Ala Arg Lys Met Arg Leu 
145                 150                 155                 160 


Gly Ser Ala Phe Gly Ala Phe Leu Asp Pro Val Ala Asp Lys Leu Met 
                165                 170                 175     


Val Ala Ala Thr Leu Ile Leu Leu Cys Thr Lys Pro Ile Gln Val Ala 
            180                 185                 190         


Glu Leu Gly Pro Leu Pro Trp Leu Leu Thr Val Pro Ser Ile Ala Ile 
        195                 200                 205             


Ile Gly Arg Glu Ile Thr Met Ser Ala Val Arg Glu Trp Ala Ala Ser 
    210                 215                 220                 


Gln Asn Gly Lys Leu Leu Glu Ala Val Ala Val Asn Asn Leu Gly Lys 
225                 230                 235                 240 


Trp Lys Thr Ala Thr Gln Met Thr Ala Leu Thr Ile Leu Leu Ala Ser 
                245                 250                 255     


Arg Asp Ser Asn Val Gly Trp Leu Val Ala Ser Gly Ala Gly Leu Leu 
            260                 265                 270         


Tyr Val Ser Ala Gly Leu Ser Val Trp Ser Leu Ala Val Tyr Met Arg 
        275                 280                 285             


Lys Ile Trp Lys Val Leu Met Lys 
    290                 295     


<210>  17
<211>  920
<212>  DNA
<213>  Unknown

<220>
<223>  Description of sequence: Arabidopsis multiresistance-like ABC 
       transporter AtPGP1 (aa 980 - 1286)

<400>  17
cactggctcc tgatttcatc aaaggtggtc aagctatgcg gtctgttttc gaacttcttg       60

accggaaaac cgagattgaa cctgatgatc ctgataccac cccggtccca gaccggttac      120

gtggtgaagt cgagctcaaa catatcgatt tctcttaccc ttcaaggcca gacatccaga      180

ttttccgtga ccttagcctt cgtgctagag ctggcaaaac cctagctctt gtgggtccaa      240

gcgggtgcgg aaaaagctca gttatctccc tcatccagag attctacgaa ccttcctcag      300

gccgagtcat gatcgacggg aaagacataa ggaaatacaa cctgaaagcc ataaggaaac      360

acatagccat agtccctcaa gagccgtgct tgttcggaac taccatttac gaaaacattg      420

catatggaca tgaatgtgcg accgaagcag agatcataca agccgcgact ctagccagtg      480

cgcacaaatt catatccgcg ctaccagaag gttacaaaac gtatgttggc gagagaggcg      540

ttcagctctc gggaggacag aaacagagga tcgcgatcgc acgtgccctc gtgaggaaag      600

cagagatcat gctgcttgac gaggctacaa gcgctcttga tgcagagtcc gagagatcag      660

tccaagaagc attagaccag gcttgctctg gtagaacatc aatagtcgtg gctcataggc      720

tatctacaat caggaacgca cacgtgatcg ctgtcatcga tgatggaaaa gtggctgaac      780

aaggatcgca ttcgcatctt ctcaagaacc atcctgatgg aatctacgcg cgaatgatac      840

agttgcaaag atttacgcat acacaagtga ttggtatgac gtcaggttca agttctaggg      900

ttaaggaaga tgatgcttag                                                  920


<210>  18
<211>  306
<212>  PRT
<213>  Unknown

<220>
<223>  Description of sequence: Arabidopsis multiresistance-like ABC 
       transporter AtPGP1 (aa 980 - 1286)

<400>  18

Thr Leu Ala Pro Asp Phe Ile Lys Gly Gly Gln Ala Met Arg Ser Val 
1               5                   10                  15      


Phe Glu Leu Leu Asp Arg Lys Thr Glu Ile Glu Pro Asp Asp Pro Asp 
            20                  25                  30          


Thr Thr Pro Val Pro Asp Arg Leu Arg Gly Glu Val Glu Leu Lys His 
        35                  40                  45              


Ile Asp Phe Ser Tyr Pro Ser Arg Pro Asp Ile Gln Ile Phe Arg Asp 
    50                  55                  60                  


Leu Ser Leu Arg Ala Arg Ala Gly Lys Thr Leu Ala Leu Val Gly Pro 
65                  70                  75                  80  


Ser Gly Cys Gly Lys Ser Ser Val Ile Ser Leu Ile Gln Arg Phe Tyr 
                85                  90                  95      


Glu Pro Ser Ser Gly Arg Val Met Ile Asp Gly Lys Asp Ile Arg Lys 
            100                 105                 110         


Tyr Asn Leu Lys Ala Ile Arg Lys His Ile Ala Ile Val Pro Gln Glu 
        115                 120                 125             


Pro Cys Leu Phe Gly Thr Thr Ile Tyr Glu Asn Ile Ala Tyr Gly His 
    130                 135                 140                 


Glu Cys Ala Thr Glu Ala Glu Ile Ile Gln Ala Ala Thr Leu Ala Ser 
145                 150                 155                 160 


Ala His Lys Phe Ile Ser Ala Leu Pro Glu Gly Tyr Lys Thr Tyr Val 
                165                 170                 175     


Gly Glu Arg Gly Val Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala 
            180                 185                 190         


Ile Ala Arg Ala Leu Val Arg Lys Ala Glu Ile Met Leu Leu Asp Glu 
        195                 200                 205             


Ala Thr Ser Ala Leu Asp Ala Glu Ser Glu Arg Ser Val Gln Glu Ala 
    210                 215                 220                 


Leu Asp Gln Ala Cys Ser Gly Arg Thr Ser Ile Val Val Ala His Arg 
225                 230                 235                 240 


Leu Ser Thr Ile Arg Asn Ala His Val Ile Ala Val Ile Asp Asp Gly 
                245                 250                 255     


Lys Val Ala Glu Gln Gly Ser His Ser His Leu Leu Lys Asn His Pro 
            260                 265                 270         


Asp Gly Ile Tyr Ala Arg Met Ile Gln Leu Gln Arg Phe Thr His Thr 
        275                 280                 285             


Gln Val Ile Gly Met Thr Ser Gly Ser Ser Ser Arg Val Lys Glu Asp 
    290                 295                 300                 


Asp Ala 
305     


<210>  19
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of sequence: scFv fragment directed against 
       fluorescein and FITC-E2 after removal of the periplasmic signal 
       sequence

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser 
    130                 135                 140                 


Val Leu Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys Val 
145                 150                 155                 160 


Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Ala Tyr Val 
                165                 170                 175     


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
            180                 185                 190         


Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Lys Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Glu 
225                 230                 235                 240 


Phe Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Ala Ser Gly 
                245                 250                 255     


Ala Asp His His His His His His 
            260                 


