               SEQUENCE LISTING

<110> Cézanne S.A.S.

<120> Method for the selective determination of Placental Growth Factor 2

<130> W2811 PCT BLN

<150> EP13195570.0
<151> 2013-12-03

<160> 7

<170> BiSSAP 1.3

<210> 1
<211> 242
<212> PRT
<213> Homo sapiens

<220> 
<223> Precursors of PlGF (PGF) isoforms (canonical sequence)

<400> 1
Met Pro Val Met Arg Leu Phe Pro Cys Phe Leu Gln Leu Leu Ala Gly 
1               5                   10                  15      
Leu Ala Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly 
            20                  25                  30          
Asn Gly Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly 
        35                  40                  45              
Arg Ser Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu 
    50                  55                  60                  
Tyr Pro Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu 
65                  70                  75                  80  
Leu Arg Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro 
                85                  90                  95      
Val Glu Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly 
            100                 105                 110         
Asp Arg Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys 
        115                 120                 125             
Glu Cys Arg His Ser Pro Gly Arg Gln Ser Pro Asp Met Pro Gly Asp 
    130                 135                 140                 
Phe Arg Ala Asp Ala Pro Ser Phe Leu Pro Pro Arg Arg Ser Leu Pro 
145                 150                 155                 160 
Met Leu Phe Lys Met Glu Trp Gly Cys Ala Leu Thr Gly Ser Gln Ser 
                165                 170                 175     
Ala Val Trp Pro Ser Ser Pro Val Pro Glu Glu Ile Pro Arg Met His 
            180                 185                 190         
Pro Gly Arg Asn Gly Lys Lys Gln Gln Arg Lys Pro Leu Arg Glu Lys 
        195                 200                 205             
Met Lys Pro Glu Arg Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg 
    210                 215                 220                 
Glu Lys Gln Arg Pro Thr Asp Cys His Leu Cys Gly Asp Ala Val Pro 
225                 230                 235                 240 
Arg Arg 
        

<210> 2
<211> 131
<212> PRT
<213> Homo sapiens

<220> 
<223> Mature PlGF-1

<400> 2
Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly Asn Gly 
1               5                   10                  15      
Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly Arg Ser 
            20                  25                  30          
Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu Tyr Pro 
        35                  40                  45              
Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu Leu Arg 
    50                  55                  60                  
Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro Val Glu 
65                  70                  75                  80  
Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly Asp Arg 
                85                  90                  95      
Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys Glu Cys 
            100                 105                 110         
Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Cys Gly Asp Ala Val 
        115                 120                 125             
Pro Arg Arg 
    130     

<210> 3
<211> 152
<212> PRT
<213> Homo sapiens

<220> 
<223> Mature PlGF-2

<400> 3
Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly Asn Gly 
1               5                   10                  15      
Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly Arg Ser 
            20                  25                  30          
Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu Tyr Pro 
        35                  40                  45              
Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu Leu Arg 
    50                  55                  60                  
Cys Thr Gly Cys Cys Gly Asp Glu Asp Leu His Cys Val Pro Val Glu 
65                  70                  75                  80  
Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly Asp Arg 
                85                  90                  95      
Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys Glu Cys 
            100                 105                 110         
Arg Pro Leu Arg Glu Lys Met Lys Pro Glu Arg Arg Arg Pro Lys Gly 
        115                 120                 125             
Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro Thr Asp Cys His Leu 
    130                 135                 140                 
Cys Gly Asp Ala Val Pro Arg Arg 
145                 150         

<210> 4
<211> 203
<212> PRT
<213> Homo sapiens

<220> 
<223> Mature PlGF-3

<400> 4
Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly Asn Gly 
1               5                   10                  15      
Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly Arg Ser 
            20                  25                  30          
Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu Tyr Pro 
        35                  40                  45              
Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu Leu Arg 
    50                  55                  60                  
Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro Val Glu 
65                  70                  75                  80  
Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly Asp Arg 
                85                  90                  95      
Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys Glu Cys 
            100                 105                 110         
Arg His Ser Pro Gly Arg Gln Ser Pro Asp Met Pro Gly Asp Phe Arg 
        115                 120                 125             
Ala Asp Ala Pro Ser Phe Leu Pro Pro Arg Arg Ser Leu Pro Met Leu 
    130                 135                 140                 
Phe Arg Met Glu Trp Gly Cys Ala Leu Thr Gly Ser Gln Ser Ala Val 
145                 150                 155                 160 
Trp Pro Ser Ser Pro Val Pro Glu Glu Ile Pro Arg Met His Pro Gly 
                165                 170                 175     
Arg Asn Gly Lys Lys Gln Gln Arg Lys Pro Leu Arg Glu Lys Met Lys 
            180                 185                 190         
Pro Glu Arg Cys Gly Asp Ala Val Pro Arg Arg 
        195                 200             

<210> 5
<211> 224
<212> PRT
<213> Homo sapiens

<220> 
<223> Mature PlGF-4

<400> 5
Leu Pro Ala Val Pro Pro Gln Gln Trp Ala Leu Ser Ala Gly Asn Gly 
1               5                   10                  15      
Ser Ser Glu Val Glu Val Val Pro Phe Gln Glu Val Trp Gly Arg Ser 
            20                  25                  30          
Tyr Cys Arg Ala Leu Glu Arg Leu Val Asp Val Val Ser Glu Tyr Pro 
        35                  40                  45              
Ser Glu Val Glu His Met Phe Ser Pro Ser Cys Val Ser Leu Leu Arg 
    50                  55                  60                  
Cys Thr Gly Cys Cys Gly Asp Glu Asn Leu His Cys Val Pro Val Glu 
65                  70                  75                  80  
Thr Ala Asn Val Thr Met Gln Leu Leu Lys Ile Arg Ser Gly Asp Arg 
                85                  90                  95      
Pro Ser Tyr Val Glu Leu Thr Phe Ser Gln His Val Arg Cys Glu Cys 
            100                 105                 110         
Arg His Ser Pro Gly Arg Gln Ser Pro Asp Met Pro Gly Asp Phe Arg 
        115                 120                 125             
Ala Asp Ala Pro Ser Phe Leu Pro Pro Arg Arg Ser Leu Pro Met Leu 
    130                 135                 140                 
Phe Arg Met Glu Trp Gly Cys Ala Leu Thr Gly Ser Gln Ser Ala Val 
145                 150                 155                 160 
Trp Pro Ser Ser Pro Val Pro Glu Glu Ile Pro Arg Met His Pro Gly 
                165                 170                 175     
Arg Asn Gly Lys Lys Gln Gln Arg Lys Pro Leu Arg Glu Lys Met Lys 
            180                 185                 190         
Pro Glu Arg Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys 
        195                 200                 205             
Gln Arg Pro Thr Asp Cys His Leu Cys Gly Asp Ala Val Pro Arg Arg 
    210                 215                 220                 



<210> 6
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<223> Heparin binding domain

<400> 6
Arg Arg Pro Lys Gly Arg Gly Lys Arg Arg Arg Glu Lys Gln Arg Pro 
1               5                   10                  15      
Thr Asp Cys His Leu 
            20      

<210> 7
<211> 72
<212> PRT
<213> Homo sapiens

<220> 
<223> loop 3

<400> 7
His Ser Pro Gly Arg Gln Ser Pro Asp Met Pro Gly Asp Phe Arg Ala 
1               5                   10                  15      
Asp Ala Pro Ser Phe Leu Pro Pro Arg Arg Ser Leu Pro Met Leu Phe 
            20                  25                  30          
Arg Met Glu Trp Gly Cys Ala Leu Thr Gly Ser Gln Ser Ala Val Trp 
        35                  40                  45              
Pro Ser Ser Pro Val Pro Glu Glu Ile Pro Arg Met His Pro Gly Arg 
    50                  55                  60                  
Asn Gly Lys Lys Gln Gln Arg Lys 
65                  70          

