                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR EXPRESSING A 
       POLYNUCLEOTIDE OF INTEREST IN THE RETINAL PIGMENT EPITHELIUM OF A
        SUBJECT

<130>  BIO13360 HAMEL / MC

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  1
ttcatctcct ttttgtgggg                                                 20


<210>  2
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  2
ctggaaacat cctgtgttca tc                                              22


<210>  3
<211>  7
<212>  DNA
<213>  Homo sapiens

<400>  3
tagttct                                                                7


<210>  4
<211>  4
<212>  DNA
<213>  Homo sapiens

<400>  4
gatt                                                                   4


<210>  5
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  5
gtcatgcatt caatt                                                      15


<210>  6
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala 
        115                 120                 125             


Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr 
                485                 490                 495     


Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser 
            500                 505                 510         


Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys 
625                 630                 635                 640 


Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210>  7
<211>  5442
<212>  DNA
<213>  Homo sapiens

<400>  7
taatagtcac atgacacgtt tcccgtcaag atggcggata ctctcccttc ggagtttgat     60

gtgatcgtaa tagggacggg tttgcctgaa tccatcattg cagctgcatg ttcaagaagt    120

ggccggagag ttctgcatgt tgattcaaga agctactatg gaggaaactg ggccagtttt    180

agcttttcag gactattgtc ctggctaaag gaataccagg aaaacagtga cattgtaagt    240

gacagtccag tgtggcaaga ccagatcctt gaaaatgaag aagccattgc tcttagcagg    300

aaggacaaaa ctattcaaca tgtggaagta ttttgttatg ccagtcagga tttgcatgaa    360

gatgtcgaag aagctggtgc actgcagaaa aatcatgctc ttgtgacatc tgcaaactcc    420

acagaagctg cagattctgc cttcctgcct acggaggatg agtcattaag cactatgagc    480

tgtgaaatgc tcacagaaca aactccaagc agcgatccag agaatgcgct agaagtaaat    540

ggtgctgaag tgacagggga aaaagaaaac cattgtgatg ataaaacttg tgtgccatca    600

acttcagcag aagacatgag tgaaaatgtg cctatagcag aagataccac agagcaacca    660

aagaaaaaca gaattactta ctcacaaatt attaaagaag gcaggagatt taatattgat    720

ttagtatcaa agctgctgta ttctcgagga ttactaattg atcttctaat caaatctaat    780

gttagtcgat atgcagagtt taaaaatatt accaggattc ttgcatttcg agaaggacga    840

gtggaacagg ttccgtgttc cagagcagat gtctttaata gcaaacaact tactatggta    900

gaaaagcgaa tgctaatgaa atttcttaca ttttgtatgg aatatgagaa atatcctgat    960

gaatataaag gatatgaaga gatcacattt tatgaatatt taaagactca aaaattaacc   1020

cccaacctcc aatatattgt catgcattca attgcaatga catcagagac agccagcagc   1080

accatagatg gtctcaaagc taccaaaaac tttcttcact gtcttgggcg gtatggcaac   1140

actccatttt tgtttccttt atatggccaa ggagaactcc cccagtgttt ctgcaggatg   1200

tgtgctgtgt ttggtggaat ttattgtctt cgccattcag tacagtgcct tgtagtggac   1260

aaagaatcca gaaaatgtaa agcaattata gatcagtttg gtcagagaat aatctctgag   1320

catttcctcg tggaggacag ttactttcct gagaacatgt gctcacgtgt gcaatacagg   1380

cagatctcca gggcagtgct gattacagat agatctgtcc taaaaacaga ttcagatcaa   1440

cagatttcca ttttgacagt gccagcagag gaaccaggaa cttttgctgt tcgggtcatt   1500

gagttatgtt cttcaacgat gacatgcatg aaaggcacct atttggttca tttgacttgc   1560

acatcttcta aaacagcaag agaagattta gaatcagttg tgcagaaatt gtttgttcca   1620

tatactgaaa tggagataga aaatgaacaa gtagaaaagc caagaattct gtgggctctt   1680

tacttcaata tgagagattc gtcagacatc agcaggagct gttataatga tttaccatcc   1740

aacgtttatg tctgctctgg cccagattgt ggtttaggaa atgataatgc agtcaaacag   1800

gctgaaacac ttttccagga aatctgcccc aatgaagatt tctgtccccc tccaccaaat   1860

cctgaagaca ttatccttga tggagacagt ttacagccag aggcttcaga atccagtgcc   1920

ataccagagg ctaactcgga gactttcaag gaaagcacaa accttggaaa cctagaggag   1980

tcctctgaat aatggatata caccaaactg gatacccaac tttggaaatt ctgactggtc   2040

tcagagtcta cttgatagaa ggactgtttg agaaatgtta gaaagcagca gcaattataa   2100

ggcaaaatag gtaatagaaa tccaaaaggg gattttcctt atagaggaca ttccaagaac   2160

acacaacact tataaagcac attgacttgc tcattttaaa taccaaactt gtgtgactag   2220

cagatgaaaa ttataaatca attgattctc aggaatgtaa ctgtggatat gaaagtgatc   2280

ctatgcattg ttaataattc catggtctta ggacaatttt gcttaccact ttggatcttt   2340

gtttgaaagc cacattttca gaaccagctc atgtattttc tttggttatt tgaattttat   2400

tttctttatg gacaagagca tcataacata atgataaaaa catatagaaa aactaaagta   2460

tcatgatcta gatagaagcc tgtatttgga atacaggttt gttttgcttt ctatgttgag   2520

aagcattgaa aatgctaata taaaggtgtt tagacatttt tacgaataag tcagtagtgt   2580

tttttagtat cagtagtgat atttgtttgt aaattattta catattggga aaggtcaata   2640

atgaagaaat gaaagaatgg aaggaaaggt gtggataggc tcattggtat ttgaatattc   2700

tgtctgtcaa gtaactagag tattaggcta attgtctaca gacctaattt aatcctggct   2760

gtcctactga tgatatttgg taaattgttt aacttctgag cctacgtttc tccatatata   2820

aagtggaaat agtattacta tgcctactat atgagaatgg ttatgaagac aatgcaatgc   2880

catgtttaga atcggtttgc cagaagaaaa ttgttttaga attttcccat tgacttgatg   2940

aatctcaaaa gtctcacgca ggaaataatt gcttgctgtc agtcaacttc caaacaaaat   3000

agatcacagt gtttttattg cattaagctt tttaaatgaa aatttctttt ttaaagtagt   3060

attttatagt cttacagacc agtaaaaata gtaacaagta gaattgtggt tttgaaatat   3120

tactaaggaa aacactctat aaattgtttt attccttttc tggtaggtaa acctgcaacc   3180

accaaggact ccaaattgtg tatgacagtt ggtaagccct aatatacact acataaaaac   3240

gttagggctg cctgtaatcc cagcactttg ggaagctgag gtgggtagat cacttgaggt   3300

caggagttcg agaccagcct ggccaacatg gcgaaaccct gtctctacta aaaatacaaa   3360

attttagctg ggtgttatgg tgggcacctg taatcccagc tactttgaag atgaggtagc   3420

agactcactt gaaccaggga ggcggaggtt gcagtgagcc aagattttgc cactgcactc   3480

cagcctgggt gacagagcaa gactctgtct cacaaaaaaa aaaaaagggg gctgtacata   3540

ggcagcaaac taagctgcag tgatgttgcc tatatttaaa ttttctcaaa tggccaagct   3600

ctgatggtct actttatttg agcaatagtt gagacttata attgcctata aataaacaaa   3660

caaatgaact atttgttttt ttttctcaca acatctggcc tatattgtct gtcaggaagc   3720

catggctcca atgtaaagta catagttctt acatacttca actgcagctg gtccctgacc   3780

tcaccaggtt tcagagatgt tcttaaagga agccagctgt ggcaggtcac agattcatgg   3840

gaaatggaaa gaaccaagga atatagctct tgcctcacct ttctacccac tgcagatata   3900

gttcaagcca gagtaatgga agaacttaac ttactagcct ctcaggctgc tcctatccct   3960

acctcccagt gtacagcccc tccccatctc tttagtcccc tttccctcac ttcccctttt   4020

ataatgtcac acaaatcagg gacagtagga tcacattata acctactttg tcatagggat   4080

tcgatttttc ttatatcaaa tcatgtttcc tgaaacccag ctggggcata tgcactcaat   4140

gtctaataca tacttattaa tgtaccggat attggccttg cccctggata tcagcaatat   4200

attataaaag gttccagtag atgagacgat tgagtctgaa tacaattgca gtaaattgtg   4260

ccaataaaga tattgtactg ttacggtctt agagttaaag ccgcttgaat gcagcatgca   4320

cattcatgta aacagacaat cagggtaggc ctagaataac cacaaaaatt ctattggcct   4380

tactgcagcc acctatatgt agaacaatgg aggagatagt ttgtggtcca ttattgtacc   4440

ctgtttcatc cattagcatc agaatctctc tttcaggtca tttattaaat atgattgaaa   4500

tgtttaaaag ttcctgaaca tgattcatga tgattaaaat atcatacaac tgataaaaga   4560

ctttaagaac tttatatatt tcctgttgcc tcaaaatgta acagaaatta ttcttagagc   4620

tttgatttta gctatcctaa ttactgcaaa taaatatttg ttcttatagt tttaaatcaa   4680

aaagaaaagt cttgttataa aaccttaagc ttgaaatcat attaataaaa tatattgtac   4740

atagtggaaa attttcagta gctaatttaa aatttcagaa aatgctatta aagaattttg   4800

attcaagtat ttaaactgtt tagttatgca tgcttcttat taaccgaaaa tgataatacc   4860

atttagttta gtgatcagta tgagaagcaa tacctaatcc tatgttgcta ttgtattttt   4920

tcctagttgg tgtgcctgct cagaaaaaca tatactgtat gtgtatacat acctgtgtat   4980

atataaaagg tcaatttata tatttttcta taggaaaatg gagtaacaag ttccctatct   5040

cccatattta tttgtccata gtaaaatggc cacattgatg ataatttcta gaactagttt   5100

ctgagattgt cagccctttg tctaaaataa tggcagtatt aatgattgac ttctgtcact   5160

gccatagtta cctggattgt cagccttggt agcctttgtc taaagtccta aagagttcca   5220

aaaaaaatgt gttgaaattt aattgctaaa tagtggttgg tgattcttta cagtaggaat   5280

tgtaataatt ttcttgcaaa taagttattt actgctattg atattgaata atttgtcttt   5340

tattcagata tatttcaaaa agcatgaata tatgattatt cataaattgt atactttacc   5400

agtaagtttt cagaggaaat aaagactttt aaatcctttt ca                      5442


