﻿               SEQUENCE LISTING

<110> Life & Brain GmbH
      Rheinische Friedrich-Wilhelms Universität Bonn

<120> Means and methods for establishing a clinical prognosis of diseases associated with the formation of aggregates of Aβ1-42

<130> 456-12 PCT

<150> EP 13 196 119.5
<151> December 6, 2013

<160> 38

<170> BiSSAP 1.0

<210> 1
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 1
gtatacaggt ggaggaacag aaaagaatgt ggtgcatttg agaaactgaa ca             52


<210> 2
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 2
gtatacaggt ggaggaacag aaaagagtgt ggtgcatttg agaaactgaa ca             52


<210> 3
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 3
gcccgtctct gtcacaacta cttacctttg ttgcagcatg aaagcaatca ta             52


<210> 4
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 4
gcccgtctct gtcacaacta cttacccttg ttgcagcatg aaagcaatca ta             52


<210> 5
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 5
caatctgtcc ttattctgtc tattcttttc ttcctaaatt cttcacttta ct             52


<210> 6
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 6
caatctgtcc ttattctgtc tattctcttc ttcctaaatt cttcacttta ct             52


<210> 7
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 7
atgcttctgt agttgtcagc agacagagta gtagtggtta agtcaggtat ta             52


<210> 8
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 8
atgcttctgt agttgtcagc agacagggta gtagtggtta agtcaggtat ta             52


<210> 9
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 9
ttcctttaac cccacatata ttgtcactat caatattttt aaaaataaac tt             52


<210> 10
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 10
ttcctttaac cccacatata ttgtcattat caatattttt aaaaataaac tt             52


<210> 11
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 11
atcactcact ctgggcaagc caactgtcaa gccataagga cggacactca ag             52


<210> 12
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 12
atcactcact ctgggcaagc caactgccaa gccataagga cggacactca ag             52


<210> 13
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 13
acatactggc ttcccatctg ctcctcttcc caaatcttac agaaaacact tt             52


<210> 14
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 14
acatactggc ttcccatctg ctcctcctcc caaatcttac agaaaacact tt             52


<210> 15
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 15
tctttttttt tttttagtag agatggaatt tcaccatatt ggccaggctg gt             52


<210> 16
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 16
tctttttttt tttttagtag agatgggatt tcaccatatt ggccaggctg gt             52


<210> 17
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 17
aaggttgtaa gtttcaagta ttttccttgt gtggccatga attatgccta tt             52


<210> 18
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 18
aaggttgtaa gtttcaagta ttttccatgt gtggccatga attatgccta tt             52


<210> 19
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 19
tgcagcttgg ataattgatg tttgtacgcc tggatttaat aaaaaatact ct             52


<210> 20
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 20
tgcagcttgg ataattgatg tttgtatgcc tggatttaat aaaaaatact ct             52


<210> 21
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 21
ataatgcagt atctatattt tatttgcaat gggagctaca ttggtgcaga tt             52


<210> 22
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 22
ataatgcagt atctatattt tatttgtaat gggagctaca ttggtgcaga tt             52


<210> 23
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 23
agaaagctat tttgattctc tgaaaataaa gcttcagagg ataagaaaga tg             52


<210> 24
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 24
agaaagctat tttgattctc tgaaaagaaa gcttcagagg ataagaaaga tg             52


<210> 25
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 25
atcctgtcat ttaatactca tagcaatcct gctgagttgt ttctattaat at             52


<210> 26
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 26
atcctgtcat ttaatactca tagcaaccct gctgagttgt ttctattaat at             52


<210> 27
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 27
ggatacacaa gtatcaatag ctagattgat caagtggaag aaaggatatc ag             52


<210> 28
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 28
ggatacacaa gtatcaatag ctagatcgat caagtggaag aaaggatatc ag             52


<210> 29
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 29
gtctcacagt gtttgcaggt cagaagcctg gcaggatgta actggatttt ct             52


<210> 30
<211> 52
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..52
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 30
gtctcacagt gtttgcaggt cagaagtctg gcaggatgta actggatttt ct             52


<210> 31
<211> 42
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..42
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 31
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                   15    
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                   25                  30        
Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                   40        

<210> 32
<211> 43
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..43
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 32
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                   15    
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                   25                  30        
Gly Leu Met Val Gly Gly Val Val Ile Ala Thr 
        35                   40            

<210> 33
<211> 432
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..432
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 33
Met Ala Ser Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu 
1               5                   10                   15    
Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu 
            20                   25                  30        
Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln Ser Lys Lys Leu 
        35                   40                  45            
Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr 
    50                   55                  60                
Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile 
65                   70                  75                  80
Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe 
                85                   90                  95    
Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val 
            100                  105                110        
Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys 
        115                  120                125            
Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu 
    130                  135                140                
Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg 
145                  150                155                  160
Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp 
                165                  170                175    
Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln 
            180                  185                190        
Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala 
        195                  200                205            
Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln 
    210                  215                220                
Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val 
225                  230                235                  240
Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe 
                245                  250                255    
Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp 
            260                  265                270        
Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu 
        275                  280                285            
Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala 
    290                  295                300                
Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile 
305                  310                315                  320
Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly 
                325                  330                335    
Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp 
            340                  345                350        
Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn 
        355                  360                365            
Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu 
    370                  375                380                
Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Asn Val Gln Glu 
385                  390                395                  400
Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile Thr Ser Ala Ile 
                405                  410                415    
Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser Val Ala Lys Lys 
            420                  425                430        

<210> 34
<211> 440
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..440
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 34
Met Ala Ser Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu 
1               5                   10                   15    
Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu 
            20                   25                  30        
Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln Ser Lys Lys Leu 
        35                   40                  45            
Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr 
    50                   55                  60                
Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile 
65                   70                  75                  80
Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe 
                85                   90                  95    
Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val 
            100                  105                110        
Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys 
        115                  120                125            
Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu 
    130                  135                140                
Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg 
145                  150                155                  160
Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp 
                165                  170                175    
Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln 
            180                  185                190        
Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala 
        195                  200                205            
Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln 
    210                  215                220                
Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val 
225                  230                235                  240
Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe 
                245                  250                255    
Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp 
            260                  265                270        
Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu 
        275                  280                285            
Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala 
    290                  295                300                
Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile 
305                  310                315                  320
Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly 
                325                  330                335    
Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp 
            340                  345                350        
Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn 
        355                  360                365            
Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu 
    370                  375                380                
Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Phe Met Glu Lys 
385                  390                395                  400
Lys Gly Ser Tyr Met His Ile Lys Gln Glu Thr Gly Asn Ser Asn Glu 
                405                  410                415    
Asn Ile Thr Gly Ile Gln Glu Asn Val Ala His Gln Asn Leu Ser Lys 
            420                  425                430        
Cys Ala Ile Ser Ile Phe Leu Cys 
        435                  440

<210> 35
<211> 346
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..346
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 35
Met Thr Ala Thr Leu Ala Ala Ala Ala Asp Ile Ala Thr Met Val Ser 
1               5                   10                   15    
Gly Ser Ser Gly Leu Ala Ala Ala Arg Leu Leu Ser Arg Ser Phe Leu 
            20                   25                  30        
Leu Pro Gln Asn Gly Ile Arg His Cys Ser Tyr Thr Ala Ser Arg Gln 
        35                   40                  45            
His Leu Tyr Val Asp Lys Asn Thr Lys Ile Ile Cys Gln Gly Phe Thr 
    50                   55                  60                
Gly Lys Gln Gly Thr Phe His Ser Gln Gln Ala Leu Glu Tyr Gly Thr 
65                   70                  75                  80
Lys Leu Val Gly Gly Thr Thr Pro Gly Lys Gly Gly Gln Thr His Leu 
                85                   90                  95    
Gly Leu Pro Val Phe Asn Thr Val Lys Glu Ala Lys Glu Gln Thr Gly 
            100                  105                110        
Ala Thr Ala Ser Val Ile Tyr Val Pro Pro Pro Phe Ala Ala Ala Ala 
        115                  120                125            
Ile Asn Glu Ala Ile Glu Ala Glu Ile Pro Leu Val Val Cys Ile Thr 
    130                  135                140                
Glu Gly Ile Pro Gln Gln Asp Met Val Arg Val Lys His Lys Leu Leu 
145                  150                155                  160
Arg Gln Glu Lys Thr Arg Leu Ile Gly Pro Asn Cys Pro Gly Val Ile 
                165                  170                175    
Asn Pro Gly Glu Cys Lys Ile Gly Ile Met Pro Gly His Ile His Lys 
            180                  185                190        
Lys Gly Arg Ile Gly Ile Val Ser Arg Ser Gly Thr Leu Thr Tyr Glu 
        195                  200                205            
Ala Val His Gln Thr Thr Gln Val Gly Leu Gly Gln Ser Leu Cys Val 
    210                  215                220                
Gly Ile Gly Gly Asp Pro Phe Asn Gly Thr Asp Phe Ile Asp Cys Leu 
225                  230                235                  240
Glu Ile Phe Leu Asn Asp Ser Ala Thr Glu Gly Ile Ile Leu Ile Gly 
                245                  250                255    
Glu Ile Gly Gly Asn Ala Glu Glu Asn Ala Ala Glu Phe Leu Lys Gln 
            260                  265                270        
His Asn Ser Gly Pro Asn Ser Lys Pro Val Val Ser Phe Ile Ala Gly 
        275                  280                285            
Leu Thr Ala Pro Pro Gly Arg Arg Met Gly His Ala Gly Ala Ile Ile 
    290                  295                300                
Ala Gly Gly Lys Gly Gly Ala Lys Glu Lys Ile Ser Ala Leu Gln Ser 
305                  310                315                  320
Ala Gly Val Val Val Ser Met Ser Pro Ala Gln Leu Gly Thr Thr Ile 
                325                  330                335    
Tyr Lys Glu Phe Glu Lys Arg Lys Met Leu 
            340                  345    

<210> 36
<211> 24
<212> RNA
<213> artificial sequences

<220> 
<221> source
<222> 1..24
<223> /mol_type="RNA"
      /note="siRNA"
      /organism="artificial sequences"

<400> 36
gcgguuugaa aggagguguu cauu                                           24


<210> 37
<211> 25
<212> RNA
<213> artificial sequences

<220> 
<221> source
<222> 1..25
<223> /mol_type="RNA"
      /note="siRNA"
      /organism="artificial sequences"

<400> 37
cccuggauau uucuagagaa acaua                                          25


<210> 38
<211> 25
<212> RNA
<213> artificial sequences

<220> 
<221> source
<222> 1..25
<223> /mol_type="RNA"
      /note="siRNA"
      /organism="artificial sequences"

<400> 38
accaggcugc agaucagauu acaaa                                          25


