                         SEQUENCE LISTING

<110>  Parry, Graham
       Panicker, Sandip
 
<120>  COMPLEMENT COMPONENT BIOMARKER ASSAYS

<130>  TNRX-802WO

<150>  US 61/913,171
<151>  2013-12-06

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln 
1               5                   10          


<210>  2
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  3

His Gln Tyr Tyr Arg Leu Pro Pro Ile Thr 
1               5                   10  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gly Phe Thr Phe Ser Asn Tyr Ala Met Ser Trp Val 
1               5                   10          


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  7
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Asp Ile Val Met Thr Gln Thr Thr Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Leu Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 


<210>  8
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Gln Val Lys Leu Glu Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr 
        115 


<210>  9
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  10
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  11
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Asn Tyr Ala Met Ser 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Leu Phe Thr Gly Tyr Ala Met Asp Tyr 
1               5                   


<210>  14
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Leu Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 


<210>  15
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser His Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Phe Thr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  16
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Pro Thr Met Tyr Gly Glu Ile Leu Ser Pro Asn Tyr Pro Gln Ala 
1               5                   10                  15      


Tyr Pro Ser Glu Val Glu Lys Ser Trp Asp Ile Glu Val Pro Glu Gly 
            20                  25                  30          


Tyr Gly Ile His Leu Tyr Phe Thr His Leu Asp Ile Glu Leu Ser Glu 
        35                  40                  45              


Asn Cys Ala Tyr Asp Ser Val Gln Ile Ile Ser Gly Asp Thr Glu Glu 
    50                  55                  60                  


Gly Arg Leu Cys Gly Gln Arg Ser Ser Asn Asn Pro His Ser Pro Ile 
65                  70                  75                  80  


Val Glu Glu Phe Gln Val Pro Tyr Asn Lys Leu Gln Val Ile Phe Lys 
                85                  90                  95      


Ser Asp Phe Ser Asn Glu Glu Arg Phe Thr Gly Phe Ala Ala Tyr Tyr 
            100                 105                 110         


Val Ala Thr Asp Ile Asn Glu Cys Thr Asp Phe Val Asp Val Pro Cys 
        115                 120                 125             


Ser His Phe Cys Asn Asn Phe Ile Gly Gly Tyr Phe Cys Ser Cys Pro 
    130                 135                 140                 


Pro Glu Tyr Phe Leu His Asp Asp Met Lys Asn Cys Gly Val Asn Cys 
145                 150                 155                 160 


Ser Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn 
                165                 170                 175     


Tyr Pro Lys Pro Tyr Pro Glu Asn Ser Arg Cys Glu Tyr Gln Ile Arg 
            180                 185                 190         


Leu Glu Lys Gly Phe Gln Val Val Val Thr Leu Arg Arg Glu Asp Phe 
        195                 200                 205             


Asp Val Glu Ala Ala Asp Ser Ala Gly Asn Cys Leu Asp Ser Leu Val 
    210                 215                 220                 


Phe Val Ala Gly Asp Arg Gln Phe Gly Pro Tyr Cys Gly His Gly Phe 
225                 230                 235                 240 


Pro Gly Pro Leu Asn Ile Glu Thr Lys Ser Asn Ala Leu Asp Ile Ile 
                245                 250                 255     


Phe Gln Thr Asp Leu Thr Gly Gln Lys Lys Gly Trp Lys Leu Arg Tyr 
            260                 265                 270         


His Gly Asp Pro Met Pro Cys Pro Lys Glu Asp Thr Pro Asn Ser Val 
        275                 280                 285             


Trp Glu Pro Ala Lys Ala Lys Tyr Val Phe Arg Asp Val Val Gln Ile 
    290                 295                 300                 


Thr Cys Leu Asp Gly Phe Glu Val Val Glu Gly Arg Val Gly Ala Thr 
305                 310                 315                 320 


Ser Phe Tyr Ser Thr Cys Gln Ser Asn Gly Lys Trp Ser Asn Ser Lys 
                325                 330                 335     


Leu Lys Cys Gln Pro Val Asp Cys Gly Ile Pro Glu Ser Ile Glu Asn 
            340                 345                 350         


Gly Lys Val Glu Asp Pro Glu Ser Thr Leu Phe Gly Ser Val Ile Arg 
        355                 360                 365             


Tyr Thr Cys Glu Glu Pro Tyr Tyr Tyr Met Glu Asn Gly Gly Gly Gly 
    370                 375                 380                 


Glu Tyr His Cys Ala Gly Asn Gly Ser Trp Val Asn Glu Val Leu Gly 
385                 390                 395                 400 


Pro Glu Leu Pro Lys Cys Val Pro Val Cys Gly Val Pro Arg Glu Pro 
                405                 410                 415     


Phe Glu Glu Lys Gln Arg Ile Ile Gly Gly Ser Asp Ala Asp Ile Lys 
            420                 425                 430         


Asn Phe Pro Trp Gln Val Phe Phe Asp Asn Pro Trp Ala Gly Gly Ala 
        435                 440                 445             


Leu Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu Gly 
    450                 455                 460                 


Asn Arg Glu Pro Thr Met Tyr Val Gly Ser Thr Ser Val Gln Thr Ser 
465                 470                 475                 480 


Arg Leu Ala Lys Ser Lys Met Leu Thr Pro Glu His Val Phe Ile His 
                485                 490                 495     


Pro Gly Trp Lys Leu Leu Glu Val Pro Glu Gly Arg Thr Asn Phe Asp 
            500                 505                 510         


Asn Asp Ile Ala Leu Val Arg Leu Lys Asp Pro Val Lys Met Gly Pro 
        515                 520                 525             


Thr Val Ser Pro Ile Cys Leu Pro Gly Thr Ser Ser Asp Tyr Asn Leu 
    530                 535                 540                 


Met Asp Gly Asp Leu Gly Leu Ile Ser Gly Trp Gly Arg Thr Glu Lys 
545                 550                 555                 560 


Arg Asp Arg Ala Val Arg Leu Lys Ala Ala Arg Leu Pro Val Ala Pro 
                565                 570                 575     


Leu Arg Lys Cys Lys Glu Val Lys Val Glu Lys Pro Thr Ala Asp Ala 
            580                 585                 590         


Glu Ala Tyr Val Phe Thr Pro Asn Met Ile Cys Ala Gly Gly Glu Lys 
        595                 600                 605             


Gly Met Asp Ser Cys Lys Gly Asp Ser Gly Gly Ala Phe Ala Val Gln 
    610                 615                 620                 


Asp Pro Asn Asp Lys Thr Lys Phe Tyr Ala Ala Gly Leu Val Ser Trp 
625                 630                 635                 640 


Gly Pro Gln Cys Gly Thr Tyr Gly Leu Tyr Thr Arg Val Lys Asn Tyr 
                645                 650                 655     


Val Asp Trp Ile Met Lys Thr Met Gln Glu Asn Ser Thr Pro Arg Glu 
            660                 665                 670         


Asp 
    


<210>  17
<211>  534
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (485)..(485)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln Asp Gly Val 
1               5                   10                  15      


Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala Ala Arg Val 
            20                  25                  30          


Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala 
        35                  40                  45              


Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala Gly Leu Gln 
    50                  55                  60                  


Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp 
65                  70                  75                  80  


Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu 
                85                  90                  95      


Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu 
            100                 105                 110         


Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu 
        115                 120                 125             


Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu 
    130                 135                 140                 


His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu 
145                 150                 155                 160 


Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val 
                165                 170                 175     


His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu 
            180                 185                 190         


Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe 
        195                 200                 205             


Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys Val Val Ala 
    210                 215                 220                 


Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu 
225                 230                 235                 240 


Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu 
                245                 250                 255     


Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn 
            260                 265                 270         


Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg 
        275                 280                 285             


Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu 
    290                 295                 300                 


Ser Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly 
305                 310                 315                 320 


Glu Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr 
                325                 330                 335     


Leu Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp 
            340                 345                 350         


His Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe 
        355                 360                 365             


Arg Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg Gly Ser Ser 
    370                 375                 380                 


Thr Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu 
385                 390                 395                 400 


Gln Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu 
                405                 410                 415     


Leu Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Pro Cys Pro Val 
            420                 425                 430         


Leu Asp Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val 
        435                 440                 445             


Ala Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val 
    450                 455                 460                 


Phe Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser 
465                 470                 475                 480 


Ile Ser Lys Ala Xaa Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu 
                485                 490                 495     


Leu Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr 
            500                 505                 510         


Lys Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala 
        515                 520                 525             


Met Ala Gln Glu Thr Gly 
    530                 


<210>  18
<211>  1744
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Tyr Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


