                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Exendin-4 Peptide Analogues

<130>  DE2013/244

<150>  EP13306716.5
<151>  2013-12-13

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Amidated C-terminus

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  3
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  4
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Liraglutide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys derivatized at N6 with 
       (S)-4-carboxy-4-hexadecanoylamino-butyryl

<400>  4

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  5

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  (S)-alpha-methyl lysine

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  6

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  7

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala His Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  9

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  10

His Ser His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  12

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  13

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  14

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  15

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  16

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  17

His Ser His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  18

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  19

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  20

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln His Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  21

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Gln Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  22
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Gln Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


