                         SEQUENCE LISTING

<110>  University of Rochester
       Daiss, John L.
       Schwarz, Edward
       Varrone, John J.
       Brodell, James  Jr.
       Bello-Irizarry, Sheila N.
 
<120>  PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS INFECTIONS

<130>  29556.3431 (6-2200)

<150>  61/915,953
<151>  2013-12-13

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  585
<212>  PRT
<213>  Artificial

<220>
<223>  His-labeled, N-acetylmuramoyl-L-alanine amidase from 
       Staphylococcus aureus

<400>  1

Met His His His His His His Ser Ala Ser Ala Gln Pro Arg Ser Val 
1               5                   10                  15      


Ala Ala Thr Pro Lys Thr Ser Leu Pro Lys Tyr Lys Pro Gln Val Asn 
            20                  25                  30          


Ser Ser Ile Asn Asp Tyr Ile Arg Lys Asn Asn Leu Lys Ala Pro Lys 
        35                  40                  45              


Ile Glu Glu Asp Tyr Thr Ser Tyr Phe Pro Lys Tyr Ala Tyr Arg Asn 
    50                  55                  60                  


Gly Val Gly Arg Pro Glu Gly Ile Val Val His Asp Thr Ala Asn Asp 
65                  70                  75                  80  


Arg Ser Thr Ile Asn Gly Glu Ile Ser Tyr Met Lys Asn Asn Tyr Gln 
                85                  90                  95      


Asn Ala Phe Val His Ala Phe Val Asp Gly Asp Arg Ile Ile Glu Thr 
            100                 105                 110         


Ala Pro Thr Asp Tyr Leu Ser Trp Gly Val Gly Ala Val Gly Asn Pro 
        115                 120                 125             


Arg Phe Ile Asn Val Glu Ile Val His Thr His Asp Tyr Ala Ser Phe 
    130                 135                 140                 


Ala Arg Ser Met Asn Asn Tyr Ala Asp Tyr Ala Ala Thr Gln Leu Gln 
145                 150                 155                 160 


Tyr Tyr Gly Leu Lys Pro Asp Ser Ala Glu Tyr Asp Gly Asn Gly Thr 
                165                 170                 175     


Val Trp Thr His Tyr Ala Val Ser Lys Tyr Leu Gly Gly Thr Asp His 
            180                 185                 190         


Ala Asp Pro His Gly Tyr Leu Arg Ser His Asn Tyr Ser Tyr Asp Gln 
        195                 200                 205             


Leu Tyr Asp Leu Ile Asn Glu Lys Tyr Leu Ile Lys Met Gly Lys Val 
    210                 215                 220                 


Ala Pro Trp Gly Thr Gln Ser Thr Thr Thr Pro Thr Thr Pro Ser Lys 
225                 230                 235                 240 


Pro Thr Thr Pro Ser Lys Pro Ser Thr Gly Lys Leu Thr Val Ala Ala 
                245                 250                 255     


Asn Asn Gly Val Ala Gln Ile Lys Pro Thr Asn Ser Gly Leu Tyr Thr 
            260                 265                 270         


Thr Val Tyr Asp Lys Thr Gly Lys Ala Thr Asn Glu Val Gln Lys Thr 
        275                 280                 285             


Phe Ala Val Ser Lys Thr Ala Thr Leu Gly Asn Gln Lys Phe Tyr Leu 
    290                 295                 300                 


Val Gln Asp Tyr Asn Ser Gly Asn Lys Phe Gly Trp Val Lys Glu Gly 
305                 310                 315                 320 


Asp Val Val Tyr Asn Thr Ala Lys Ser Pro Val Asn Val Asn Gln Ser 
                325                 330                 335     


Tyr Ser Ile Lys Pro Gly Thr Lys Leu Tyr Thr Val Pro Trp Gly Thr 
            340                 345                 350         


Ser Lys Gln Val Ala Gly Ser Val Ser Gly Ser Gly Asn Gln Thr Phe 
        355                 360                 365             


Lys Ala Ser Lys Gln Gln Gln Ile Asp Lys Ser Ile Tyr Leu Tyr Gly 
    370                 375                 380                 


Ser Val Asn Gly Lys Ser Gly Trp Val Ser Lys Ala Tyr Leu Val Asp 
385                 390                 395                 400 


Thr Ala Lys Pro Thr Pro Thr Pro Thr Pro Lys Pro Ser Thr Pro Thr 
                405                 410                 415     


Thr Asn Asn Lys Leu Thr Val Ser Ser Leu Asn Gly Val Ala Gln Ile 
            420                 425                 430         


Asn Ala Lys Asn Asn Gly Leu Phe Thr Thr Val Tyr Asp Lys Thr Gly 
        435                 440                 445             


Lys Pro Thr Lys Glu Val Gln Lys Thr Phe Ala Val Thr Lys Glu Ala 
    450                 455                 460                 


Ser Leu Gly Gly Asn Lys Phe Tyr Leu Val Lys Asp Tyr Asn Ser Pro 
465                 470                 475                 480 


Thr Leu Ile Gly Trp Val Lys Gln Gly Asp Val Ile Tyr Asn Asn Ala 
                485                 490                 495     


Lys Ser Pro Val Asn Val Met Gln Thr Tyr Thr Val Lys Pro Gly Thr 
            500                 505                 510         


Lys Leu Tyr Ser Val Pro Trp Gly Thr Tyr Lys Gln Glu Ala Gly Ala 
        515                 520                 525             


Val Ser Gly Thr Gly Asn Gln Thr Phe Lys Ala Thr Lys Gln Gln Gln 
    530                 535                 540                 


Ile Asp Lys Ser Ile Tyr Leu Phe Gly Thr Val Asn Gly Lys Ser Gly 
545                 550                 555                 560 


Trp Val Ser Lys Ala Tyr Leu Ala Val Pro Ala Ala Pro Lys Lys Ala 
                565                 570                 575     


Val Ala Gln Pro Lys Thr Ala Val Lys 
            580                 585 


<210>  2
<211>  1755
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid encoding His-labeled, N-acetylmuramoyl-L-alanine 
       amidase from Staphylococcus aureus

<400>  2
atgcaccatc accaccacca cagcgcaagc gcacagcctc gttccgtcgc cgccaccccg       60

aaaaccagct tgccgaagta caaaccgcaa gttaatagca gcatcaacga ctacatccgc      120

aaaaacaacc tgaaggcccc gaaaattgaa gaggactata ccagctattt cccgaaatat      180

gcttaccgta atggtgtcgg tcgtccggag ggtattgtgg tccacgacac cgcgaatgac      240

cgtagcacca tcaacggtga gattagctac atgaaaaaca attaccaaaa cgcgttcgtg      300

cacgccttcg tcgatggcga tcgcatcatc gaaaccgcgc caaccgacta tctgtcctgg      360

ggtgtgggtg ccgttggcaa cccgcgtttc atcaatgtgg agattgttca tacccacgac      420

tacgcgagct ttgcacgtag catgaacaac tacgccgatt atgctgcaac gcagctgcag      480

tactacggcc tgaaaccgga tagcgcggag tatgacggta acggtacggt gtggacgcat      540

tatgcggtga gcaaatacct gggtggtacc gatcatgctg atccgcatgg ctacctgcgc      600

tctcacaact atagctacga ccagttgtac gacctgatca atgagaaata tctgattaag      660

atgggtaagg ttgcaccgtg gggtacgcag agcaccacga cgccgaccac gccgagcaaa      720

ccgacgaccc cgtccaaacc gtctaccggc aaactgacgg tcgcggctaa taacggtgtc      780

gcgcagatta aaccgaccaa cagcggtctg tacaccaccg tctatgataa aacgggcaaa      840

gccaccaatg aggttcaaaa gacgttcgca gttagcaaaa cggcgaccct gggtaaccaa      900

aagttctacc tggttcagga ttacaatagc ggcaacaaat ttggttgggt gaaagaaggc      960

gacgttgtgt acaataccgc gaagtccccg gtgaacgtta atcagagcta tagcatcaag     1020

ccgggtacca aattgtatac ggtgccgtgg ggtaccagca agcaagttgc gggtagcgtc     1080

agcggctctg gtaaccagac cttcaaggcg tctaagcaac aacaaattga caaaagcatt     1140

tacctgtatg gtagcgttaa tggtaaaagc ggctgggtgt ctaaagcgta tctggtcgac     1200

accgcaaagc cgacgccaac gccgaccccg aagccgagca ccccaaccac caacaacaag     1260

ctgacggtca gctccctgaa tggtgttgcg caaatcaatg cgaagaataa tggcctgttt     1320

accaccgttt acgataagac gggcaagcca acgaaagaag tccagaaaac ctttgctgtc     1380

accaaagaag ccagcctggg cggtaacaag ttctatctgg ttaaggacta caactccccg     1440

acgctgatcg gttgggtcaa acaaggcgat gtcatttaca ataacgcgaa aagcccggtt     1500

aatgtgatgc aaacctatac cgtcaaaccg ggtacgaagc tgtattccgt tccgtggggc     1560

acgtacaaac aagaagcagg cgcggtgagc ggtaccggca atcagacctt taaggccacc     1620

aagcagcagc agatcgataa atctatttac ttgtttggca ccgtgaatgg caagagcggt     1680

tgggtttcta aggcatacct ggcggtgccg gcagcaccga agaaggcggt ggcgcagcca     1740

aagaccgcag tgaag                                                      1755


<210>  3
<211>  251
<212>  PRT
<213>  Artificial

<220>
<223>  His-labeled, N-acetylmuramoyl-L-alanine amidase catalytic domain 
       from Staphylococcus aureus

<400>  3

Met His His His His His His Ser Ala Ser Ala Gln Pro Arg Ser Val 
1               5                   10                  15      


Ala Ala Thr Pro Lys Thr Ser Leu Pro Lys Tyr Lys Pro Gln Val Asn 
            20                  25                  30          


Ser Ser Ile Asn Asp Tyr Ile Arg Lys Asn Asn Leu Lys Ala Pro Lys 
        35                  40                  45              


Ile Glu Glu Asp Tyr Thr Ser Tyr Phe Pro Lys Tyr Ala Tyr Arg Asn 
    50                  55                  60                  


Gly Val Gly Arg Pro Glu Gly Ile Val Val His Asp Thr Ala Asn Asp 
65                  70                  75                  80  


Arg Ser Thr Ile Asn Gly Glu Ile Ser Tyr Met Lys Asn Asn Tyr Gln 
                85                  90                  95      


Asn Ala Phe Val His Ala Phe Val Asp Gly Asp Arg Ile Ile Glu Thr 
            100                 105                 110         


Ala Pro Thr Asp Tyr Leu Ser Trp Gly Val Gly Ala Val Gly Asn Pro 
        115                 120                 125             


Arg Phe Ile Asn Val Glu Ile Val His Thr His Asp Tyr Ala Ser Phe 
    130                 135                 140                 


Ala Arg Ser Met Asn Asn Tyr Ala Asp Tyr Ala Ala Thr Gln Leu Gln 
145                 150                 155                 160 


Tyr Tyr Gly Leu Lys Pro Asp Ser Ala Glu Tyr Asp Gly Asn Gly Thr 
                165                 170                 175     


Val Trp Thr His Tyr Ala Val Ser Lys Tyr Leu Gly Gly Thr Asp His 
            180                 185                 190         


Ala Asp Pro His Gly Tyr Leu Arg Ser His Asn Tyr Ser Tyr Asp Gln 
        195                 200                 205             


Leu Tyr Asp Leu Ile Asn Glu Lys Tyr Leu Ile Lys Met Gly Lys Val 
    210                 215                 220                 


Ala Pro Trp Gly Thr Gln Ser Thr Thr Thr Pro Thr Thr Pro Ser Lys 
225                 230                 235                 240 


Pro Thr Thr Pro Ser Lys Pro Ser Thr Gly Lys 
                245                 250     


<210>  4
<211>  753
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid encoding His-labeled, N-acetylmuramoyl-L-alanine 
       amidase catalytic domain from Staphylococcus aureus

<400>  4
atgcaccatc accaccacca cagcgcaagc gcacagcctc gttccgtcgc cgccaccccg       60

aaaaccagct tgccgaagta caaaccgcaa gttaatagca gcatcaacga ctacatccgc      120

aaaaacaacc tgaaggcccc gaaaattgaa gaggactata ccagctattt cccgaaatat      180

gcttaccgta atggtgtcgg tcgtccggag ggtattgtgg tccacgacac cgcgaatgac      240

cgtagcacca tcaacggtga gattagctac atgaaaaaca attaccaaaa cgcgttcgtg      300

cacgccttcg tcgatggcga tcgcatcatc gaaaccgcgc caaccgacta tctgtcctgg      360

ggtgtgggtg ccgttggcaa cccgcgtttc atcaatgtgg agattgttca tacccacgac      420

tacgcgagct ttgcacgtag catgaacaac tacgccgatt atgctgcaac gcagctgcag      480

tactacggcc tgaaaccgga tagcgcggag tatgacggta acggtacggt gtggacgcat      540

tatgcggtga gcaaatacct gggtggtacc gatcatgctg atccgcatgg ctacctgcgc      600

tctcacaact atagctacga ccagttgtac gacctgatca atgagaaata tctgattaag      660

atgggtaagg ttgcaccgtg gggtacgcag agcaccacga cgccgaccac gccgagcaaa      720

ccgacgaccc cgtccaaacc gtctaccggc aaa                                   753


<210>  5
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala 
1               5                   10                  15      


Ser Gly Tyr Thr Phe Thr Ser Tyr Ile Met His Trp Val Lys Gln Lys 
            20                  25                  30          


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp 
        35                  40                  45              


Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser 
    50                  55                  60                  


Asp Lys Ser Ser Thr Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser 
65                  70                  75                  80  


Glu Asp Xaa Ala Val Tyr Tyr Cys Ala Arg Leu Asp Gly Tyr Tyr Asp 
                85                  90                  95      


Cys Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110     


<210>  6
<211>  425
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (248)..(248)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (330)..(330)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (416)..(416)
<223>  n is a, c, g, or t

<400>  6
cctgagctgg taaagcctgg ggcttcagtg aagatgtcct gcaaggcttc tggatacaca       60

ttcactagct atattatgca ctgggtgaag cagaagcctg ggcagggcct tgagtggatt      120

ggatatatta atccttacaa tgatggtact aagtacaatg agaagttcaa aggcaaggcc      180

acactgactt cagacaaatc ctccaccaca gcctacatgg agctcagcag cctgacctct      240

gaggactntg cggtctatta ctgtgcaaga cttgatggtt actacgactg ctttgactac      300

tggggccaag gcaccactct cacagtctcn tcagccaaaa cgacaccccc atctgtctat      360

ccactggccc ctggatctgc tgcccaaact aactccatgg tgaccctggg atgccnggtc      420

aaggg                                                                  425


<210>  7
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  7

Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
1               5                   10                  15      


Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
            20                  25                  30          


Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp 
        35                  40                  45              


Pro Ala Asn Gly Ile Thr Asn Tyr Asp Pro Lys Phe Gln Gly Arg Ala 
    50                  55                  60                  


Thr Ile Thr Ala Asp Thr Ser Ser Asn Ile Ala Tyr Leu Gln Leu Thr 
65                  70                  75                  80  


Ser Leu Thr Ser Glu Gly Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly 
                85                  90                  95      


Tyr Leu Ser Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  460
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (449)..(449)
<223>  n is a, c, g, or t

<400>  8
ntgcagcagt ctggggcaga gcttgtgaag ccaggggcct cagtcaagtt gtcctgcaca       60

gcttctggct tcaacattaa agacacctat atacattggg tgaagcagag gcctgaacag      120

ggcctggagt ggattggaag gattgatcct gcgaatggta ttactaatta tgacccgaag      180

ttccagggca gggccactat aacagcagac acatcctcca atatagccta cctgcagctc      240

accagcctga catctgaggg cactgccgtc tactactgtg ctagaggggg ttacctatcc      300

ccttatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc agccaaaacg      360

acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg      420

accctgggat gcctggtcaa gggctattnc cctgagccag                            460


<210>  9
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Leu Val Lys Leu 
1               5                   10                  15      


Ser Cys Lys Ala Ser Gly Phe Asn Ile Gln Asp Tyr Tyr Leu His Trp 
            20                  25                  30          


Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp 
        35                  40                  45              


Pro Glu Asn Asp Asn Thr Val Tyr Asp Pro Lys Phe Arg Asp Arg Ala 
    50                  55                  60                  


Ser Leu Thr Ala Asp Thr Phe Ser Asn Thr Ala Tyr Leu Gln Leu Ser 
65                  70                  75                  80  


Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Asp 
                85                  90                  95      


Gly Ile Thr Thr Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  10
<211>  464
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (450)..(454)
<223>  n is a, c, g, or t

<400>  10
tgcagcagtc tggggctgag cttgtgaggc caggggcctt agtcaaattg tcctgcaaag       60

cttctggctt caacattcaa gactactatc tacactggat gaaacagagg cctgagcagg      120

gcctggagtg gattggatgg attgatcctg agaatgataa tactgtatat gacccgaagt      180

tccgggacag ggccagttta acagcagaca cattttccaa cacagcctac ctacagctca      240

gcggcctgac atctgaagac actgccgtct attactgtgc tagaagagac ggcattacta      300

cggctacgcg ggctatggac tactggggtc aaggaacctc agtcaccgtc tcctcagcca      360

aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa actaactcca      420

tggtgaccct gggatgcctg gtcaagggcn nnnncctgag ccag                       464


<210>  11
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  11

Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Thr Ser Val Lys Met Ser 
1               5                   10                  15      


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr Trp Met His Trp Val 
            20                  25                  30          


Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ser Ile Tyr Pro 
        35                  40                  45              


Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Lys 
    50                  55                  60                  


Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
65                  70                  75                  80  


Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys Thr Gly Asp Asp Tyr 
                85                  90                  95      


Ser Arg Phe Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


<210>  12
<211>  444
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (420)..(420)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (431)..(431)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (438)..(438)
<223>  n is a, c, g, or t

<400>  12
cagtctggga ctgtactggc aaggcctggg acttccgtga agatgtcctg caaggcttct       60

ggctacagct ttaccaacta ctggatgcac tgggtaagac agaggcctgg acagggtcta      120

gaatggattg gttctattta tcctggaaat agtgatacta cctacaacca gaagttcaag      180

gacaaggcca aactgactgc agtcacatcc gccagcactg cctacatgga gctcagcagc      240

ctgacaaatg aggactctgc ggtctattac tgtacggggg atgattactc tcggttttct      300

tactggggcc aagggactct ggtcactgtc tctgcagcca aaacgacacc cccatctgtc      360

tatccactgg cccctggatc tgctgcccaa actaactcca tggtgaccct gggatgcctn      420

gtcaagggct ntttcccnga gcca                                             444


<210>  13
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  13

Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
1               5                   10                  15      


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met His Trp 
            20                  25                  30          


Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Phe 
        35                  40                  45              


Pro Tyr Asn Gly Asp Thr Asp Tyr Asn Gln Lys Phe Lys Asn Lys Ala 
    50                  55                  60                  


Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr Met Asp Leu Arg 
65                  70                  75                  80  


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
                85                  90                  95      


Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  14
<211>  433
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (423)..(423)
<223>  n is a, c, g, or t

<400>  14
tgcagcagtc aggacctgag ctggtgaaac ctggggcctc agtgaagata tcctgcaagg       60

cttctggata cacattcact gactacaaca tgcactgggt gaagcagagc catggaaaga      120

gccttgagtg gattggatat atttttcctt acaatggtga tactgactac aaccagaaat      180

tcaagaacaa ggccacattg actgtagaca attcctccag cacagcctac atggacctcc      240

gcagcctgac atctgaggac tctgcagtct attactgttc aagatggggg tcttactttg      300

actactgggg ccaaggcacc actctcacag tctcctcagc caaaacgaca cccccatctg      360

tctatccact ggcccctgga tctgctgccc aaactaactc catggtgacc ctgggatgcc      420

tgngtcaagg gct                                                         433


<210>  15
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  15

Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu 
1               5                   10                  15      


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp 
            20                  25                  30          


Val Arg Gln Thr Pro Lys Lys Ser Leu Glu Trp Val Ala Ser Ile Thr 
        35                  40                  45              


Ser Gly Gly Ser Ala Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
    50                  55                  60                  


Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Asn Leu Gln Met Ser Ser 
65                  70                  75                  80  


Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Asp Asp Gly 
                85                  90                  95      


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110     


<210>  16
<211>  422
<212>  DNA
<213>  Mus musculus

<400>  16
gtggagtctg ggggaggctt agtgaagcct ggagggtccc tgaaactctc ctgtgcagcc       60

tctggattca ctttcagtag ctatgccatg tcttgggttc gccagactcc aaaaaagagt      120

ctggagtggg tcgcatccat tactagtggt ggtagcgcct actatccaga cagtgtgaag      180

ggccgattca ccatctccag agataatgcc aggaacatcc tgaacctgca gatgagcagt      240

ctgaggtctg aggacacggc catgtattac tgtgcaagag acgacgggta ctttgactac      300

tggggccaag gcaccactct cacagtctcc tcagccaaaa cgacaccccc atctgtctat      360

ccactggccc ctggatctgc tgcccaaact aactccatgg tgaccctggg atgcctggtc      420

aa                                                                     422


<210>  17
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  17

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Leu Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Gly Tyr Phe Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  482
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  18
nncctgatgg cagctgccca aagtgcccaa gcacagatcc agttggtgca gtctggacct       60

gagctgaaga agcctggaga gacagtcaag atctcctgca aggcttctgg gtataccttc      120

acaaactatg gaatgaactg ggtgaagcag gctccaggaa agggtttaga gtggatgggc      180

tggataaaca cctacactgg agagccaact tatgctgatg acttcaaggg acgctttgcc      240

ttctctttgg aaacctctgc cagcactgcc tatttgctga tcaacaacct caaaaatgag      300

gacacggcta catatttctg tgcaagaagg gatggttact tcgatgctat ggactactgg      360

ggtcaaggaa cctcagtcac cgtctcctca gccaaaacga cacccccatc tgtctatcca      420

ctggcccctg gatctgctgc ccaaactaac tccatggtga ccctgggatg cctggtcaag      480

gg                                                                     482


<210>  19
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  19

Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Val 
1               5                   10                  15      


Ser Cys Lys Thr Ser Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu Trp 
            20                  25                  30          


Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asn 
        35                  40                  45              


Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Ala Lys Ala 
    50                  55                  60                  


Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
65                  70                  75                  80  


Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys Ala Arg Ser Glu 
                85                  90                  95      


Arg Gly Tyr Tyr Gly Asn Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  469
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (457)..(457)
<223>  n is a, c, g, or t

<400>  20
nngcagcagt ctggagctga gctggtaagg cctgggactt cagtgaaggt gtcctgcaag       60

acttctggat acgccttcac taattacttg atagagtggg taaatcagag gcctggacag      120

ggccttgagt ggattggggt gattaatcct ggaagtggtg gtactaacta caatgagaag      180

ttcaaggcca aggcaacact gactgcagac aaatcctcca gcactgccta catgcagctc      240

agcagcctga catctgatga ctctgcggtc tatttctgtg caagatcaga gcgaggctac      300

tatggtaact acggagctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac      420

tccatggtga ccctgggatg cctggtcaag ggctatntcc ctgagccag                  469


<210>  21
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Gln Pro Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Leu Lys Ile 
1               5                   10                  15      


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Ser Ser Trp Met Asn Trp 
            20                  25                  30          


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Tyr 
        35                  40                  45              


Pro Val Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala 
    50                  55                  60                  


Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
65                  70                  75                  80  


Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys Ala Arg Thr Gly 
                85                  90                  95      


Pro Tyr Ala Met Asp Tyr Trp Gly Arg Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  22
<211>  434
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  22
nngcagcagc ctggacctga gctggtgaag cctggggcct cactgaagat ttcctgcaaa       60

gcttctggct actcattcag ttcctcttgg atgaactggg tgaagcagag gcctggacag      120

ggtcttgagt ggattggacg gatttatcct gtagatggag atactaacta caatgggaag      180

ttcaagggca aggccacact gactacagac aaatcctcca gcacagccta catgcagctc      240

agcagcctga cctctgtgga ctctgcggtc tatttctgtg caagaactgg gccctatgct      300

atggactact ggggtcgagg aacctcagtc accgtctcct cagccaaaac gacaccccca      360

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga      420

tgcctggtca aggg                                                        434


<210>  23
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val Lys Ile Ser Cys Lys 
1               5                   10                  15      


Ala Ser Gly Tyr Thr Phe Ser Thr Tyr Trp Met Asn Trp Val Lys Gln 
            20                  25                  30          


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp 
        35                  40                  45              


Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr 
    50                  55                  60                  


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
65                  70                  75                  80  


Ser Asp Asp Ser Ala Val Tyr Phe Cys Ala Arg Ser Met Val Thr Asn 
                85                  90                  95      


Tyr Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  24
<211>  434
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (425)..(425)
<223>  n is a, c, g, or t

<400>  24
ggggctgagc tggtgaggcc tgggtcctca gtgaagattt cctgcaaggc ttctggctat       60

acattcagta cctactggat gaactgggtg aagcagagac ctggacaggg tcttgagtgg      120

attggacaga tttatcctgg agatggtgat actaactaca atggaaaatt caagggtaaa      180

gccacactga ctgcagacaa atcctccagc acagcctaca tgcagctcag cagcctaaca      240

tctgacgact ctgcggtcta tttctgtgca agatcgatgg taacgaacta ttactttgct      300

atggactact ggggtcaagg aacctcagtc accgtctcct cagccaaaac gacaccccca      360

tctgtctatc cactggcccc tggatctgct gcccaaacta actccatggt gaccctggga      420

tgccnggtca aggg                                                        434


<210>  25
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  25

Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
1               5                   10                  15      


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Thr 
            20                  25                  30          


Pro Glu Lys Lys Leu Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser 
        35                  40                  45              


Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    50                  55                  60                  


Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser 
65                  70                  75                  80  


Glu Asp Thr Ala Met Tyr Tyr Cys Val Arg Gly Leu Leu Gly Phe Asp 
                85                  90                  95      


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105             


<210>  26
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  26
ggggaggctt agtgaagcct ggagggtccc tgaaactctc ctgtgcagcc tctggattca       60

ctttcagtga ctattacatg tattgggttc gccagactcc ggaaaagaaa ctggagtggg      120

tcgcaaccat tagtgatggt ggtagttaca cctactatcc agacagtgtg aaggggcgat      180

tcaccatctc cagagacaat gccaagaaca acctgtacct gcaaatgagc agtctgaagt      240

ctgaggacac agccatgtat tactgtgtaa gggggctact gggttttgac tactggggcc      300

aaggcaccac tctcacagtc tcctcagcca aaacgacacc cccatctgtc tatccactgg      360

cccctggatc tgctgcccaa actaactcca tggtgaccct gggatgcctg gtcaagg         417


<210>  27
<211>  113
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Gly Phe Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro 
            20                  25                  30          


Glu Met Arg Leu Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Ser Xaa 
        35                  40                  45              


Thr Tyr Tyr Pro Asp Ser Val Met Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ala Arg Asn Ile Leu Asn Leu Gln Met Ser Ser Leu Arg Ser Glu 
65                  70                  75                  80  


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Val Gly Leu Tyr Tyr Asp Tyr 
                85                  90                  95      


Tyr Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  28
<211>  340
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (141)..(143)
<223>  n is a, c, g, or t

<400>  28
ggcttcgtga agcctggagg gtccctgaaa ctctcctgtg cagcctctgg attcactttc       60

agtagctatg ccatgtcttg ggttcgccag actccagaga tgaggctgga gtgggtcgca      120

tccattagta gtggtggtag nnncacctac tatccagaca gtgtgatggg ccgattcacc      180

atctccagag ataatgccag gaacatcctg aacctgcaaa tgagcagtct gaggtctgag      240

gacacggcca tgtattactg tgcaagagtg ggtctctact atgattatta ctattctatg      300

gactactggg gtcaaggaac ctcagtcacc gtctcctcag                            340


<210>  29
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  29

Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser 
1               5                   10                  15      


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met His Trp Val 
            20                  25                  30          


Arg Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Tyr Ile Tyr Pro 
        35                  40                  45              


Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Ser Lys Ala Thr 
    50                  55                  60                  


Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser 
65                  70                  75                  80  


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Glu Asp Gly 
                85                  90                  95      


Tyr Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Gly 
            100                 105                 110         


Ser Ser 
        


<210>  30
<211>  343
<212>  DNA
<213>  Mus musculus

<400>  30
gagtcaggac ctgagctggt gaaacctggg gcctcagtga agatatcctg caaggcttct       60

ggatacacat tcactgacta taacatgcac tgggtgaggc agagccatgg aaagagcctt      120

gagtggattg gatatattta tccttacaat ggtggtactg gctacaacca gaagttcaag      180

agtaaggcca cattgactgt agacaattcc tccagcacag cctacatgga gctccgcagc      240

ctgacatctg aggactctgc agtctattac tgtgcaagag aggatggtta ctacggctac      300

tttgactact ggggccaagg caccactctc acaggctcct cag                        343


<210>  31
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  31

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Gly Tyr Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  32
<211>  364
<212>  DNA
<213>  Mus musculus

<400>  32
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cgctgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagggactat      300

gatggttact attactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcag                                                                   364


<210>  33
<211>  98
<212>  PRT
<213>  Mus musculus

<400>  33

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Phe Trp Phe Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Glu Phe Thr Ser Phe Pro Tyr Thr 
                85                  90                  95      


Phe Gly 
        


<210>  34
<211>  324
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  34
ntcagtgtct cagttgtaat gtccagagga gaaaatgtgc tcacccagtc tccagcaatc       60

atgtctgcat ctctagggga gaaggtcacc atgacctgca gggccagctc aagtgtaaat      120

tacatgttct ggttccagca gaagtcagat gcctccccca aattgtggat ttattataca      180

tccaacctgg ctcctggagt cccagctcgc ttcagtggca gtgggtctgg gaactcttat      240

tctctcacaa tcagcagcat ggagggtgaa gatgctgcca cttattactg ccaggagttt      300

actagtttcc cgtacacgtt cgga                                             324


<210>  35
<211>  99
<212>  PRT
<213>  Mus musculus

<400>  35

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Gln 
                85                  90                  95      


Tyr Thr Phe 
            


<210>  36
<211>  331
<212>  DNA
<213>  Mus musculus

<400>  36
ttatgctttt ttggatttca gcctccagag gtgatattgt gctaactcag tctccagcca       60

ccctgtctgt gactccagga gatagcgtca gtctttcctg cagggccagc caaagtatta      120

gcaacaacct acactggtat caacaaaaat cacatgagtc tccaaggctt ctcatcaagt      180

atgcttccca gtccatctct gggatcccct ccaggttcag tggcagtgga tcagggacag      240

atttcactct cagtatcaac agtgtggaga ctgaagattt tggaatgtat ttctgtcaac      300

agagtaacag ctggcctcag tacacgttcg g                                     331


<210>  37
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  37

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Leu Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  38
<211>  355
<212>  DNA
<213>  Mus musculus

<400>  38
ccaggtcttc gtatttctac tgctctgtgt gtctggtgct catgggagta ttgtgatgac       60

ccagactccc aaattcctgc ttgtatcagc aggagacagg cttaccataa cctgcaaggc      120

cagtcagagt gtgagtaatg atgtagcttg gtaccaacag aagccagggc agtctcctaa      180

actgctgata tactatacat ccaatcgcta cactggagtc cctgatcgct tcactggcag      240

tggatatggg acggatttca ctttcaccat cagcactgtg caggctgaag acctggcagt      300

ttatttctgt cagcaggatt ataactctcc gtggacgttc ggtggaggca ccaag           355


<210>  39
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  39

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Leu Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  40
<211>  323
<212>  DNA
<213>  Mus musculus

<400>  40
tggtgctcat gggagtattg tgatgaccca gactcccaaa ttcctgcttg tatcagcagg       60

agacaggctt accataacct gcaaggccag tcagagtgtg agtaatgatg tagcttggta      120

ccaacagaag ccagggcagt ctcctaaact gctgatatac tatacatcca atcgctacac      180

tggagtccct gatcgcttca ctggcagtgg atatgggacg gatttcactt tcaccatcag      240

cactgtgcag gctgaagacc tggcagttta tttctgtcag caggattata actctccgtg      300

gacgttcggt ggaggcacca agc                                              323


<210>  41
<211>  99
<212>  PRT
<213>  Mus musculus

<400>  41

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Arg Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly 
            


<210>  42
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  42
cttggacttt tgcttttctg gacttcagcc tccagatgtg acattgtgat gactcagtct       60

ccagccaccc tgtctgtgac tccaggagat agagtctctc tttcctgcag ggccagccag      120

agtattagcg actacttaca ctggtatcaa caaagatcac atgagtctcc aaggcttctc      180

atcaaatatg tttcccaatc catctctggg atcccctcca ggttcagtgg cagtggatca      240

gggtcagatt tcactctcag tatcaacagt gtggaacctg aagatgttgg agtgtattat      300

tgtcaaaatg gtcacagctt tccgtacacg ttcgga                                336


<210>  43
<211>  98
<212>  PRT
<213>  Mus musculus

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Phe Ser Asn 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Gln Pro Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Ser Pro Trp 
                85                  90                  95      


Thr Phe 
        


<210>  44
<211>  313
<212>  DNA
<213>  Mus musculus

<400>  44
ttacagatgc cagatgtgac atccagatga ctcagtctcc agcctcccta tctgtatctg       60

tgggagaaac tgtcaccatc acatgtcgaa caagtgaaaa tattttcagt aatttcgcat      120

ggtatcagca gcaaccggga aaatctcctc agctcctggt ctatggtgca acaaacttag      180

cagatggtgt gccatcaagg ttcagtggca gtggatcagg cacacagtat tccctcaaga      240

tcaccagcct gcagtctgaa gattttggga gttattactg tcaacatttt tggggtagtc      300

cgtggacgtt cgg                                                         313


<210>  45
<211>  99
<212>  PRT
<213>  Mus musculus

<400>  45

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly 
            


<210>  46
<211>  326
<212>  DNA
<213>  Mus musculus

<400>  46
tcagtgcctc agtcataatg tccaggggac aaattgttct cacccagtct ccagcactca       60

tgtctgcatc tccaggggag aaggtcacca tgacctgcag tgccagctca agtgtaagtt      120

acatgtactg gtaccagcag aagccaagat cctcccccaa accctggatt tatctcacat      180

ccaacctggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg acctcttact      240

ctctcacaat cagcagcatg gaggctgaag atgctgccac ttattactgc cagcagtgga      300

gtagtaaccc accctacacg ttcgga                                           326


<210>  47
<211>  100
<212>  PRT
<213>  Mus musculus

<400>  47

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Ala 
                85                  90                  95      


Leu Thr Phe Gly 
            100 


<210>  48
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  48
ggacttttgc ttttctggat tccagcctcc agaggtgaca tcttgctgac tcagtctcca       60

gccatcctgt ctgtgagtcc aggagaaaga gtcagtttct cctgcagggc cagtcagagc      120

attggcacaa gcatacactg gtatcaacaa agaacaaatg gttctccaag gcttctcata      180

aagtatgctt ctgagtctat ctctgggatc ccttccaggt ttagtggcag tggatcaggg      240

acagatttta ctcttagcat caacagtgtg gagtctgaag atattgcaga ttattactgt      300

caacaaagta atagctggcc agcgctcacg ttcggt                                336


<210>  49
<211>  98
<212>  PRT
<213>  Mus musculus

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Phe Ala Glu Gly Val Arg Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Gln Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ser Pro Tyr 
                85                  90                  95      


Thr Phe 
        


<210>  50
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  50
tctgctgctg tggcttacag gtgccagatg tgacatccag atgactcagt ctccagcctc       60

cctatctgca tctgtgggag atactgtcac catcacatgt cgagcaagtg agaatattta      120

cagttattta gcatggtatc agcagaaaca gggaaaatct cctcagctcc tggtctataa      180

tgcaaaaacc ttcgcagaag gtgtgcgatc aaggttcagt ggcagtggat caggcacaca      240

gttttctctg cagatcacca gcctgcagcc tgaagatttt gggagttatt actgtcaaca      300

tcattatggt tctccgtaca cgttcgg                                          327


<210>  51
<211>  105
<212>  PRT
<213>  Mus musculus

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly 
            100                 105 


<210>  52
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  52
ggtacctgtg gggacattgt gatgacgcag tctccatcct ccctgactgt gacagcagga       60

gagaaggtca ctatgagctg caagtccagt cagagtctgt taaacagtgg aaatcaaaaa      120

aactacttga cctggtacca gcagaaacca gggcagcctc ctaaactgtt gatctcctgg      180

gcatccacta gggaatctgg ggtccctgat cgcttcacag gcagtggatc tggaacagat      240

ttcactctca ccatcagcag tgtgcaggct gaagacctgg cagtttatta ctgtcagaat      300

gactatagtt atccattcac gttcggc                                          327


<210>  53
<211>  98
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Asp Ile Ala Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Arg Asp Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Arg Cys Gly Thr Asp Phe Thr Phe Pro Ile Ser Ser Val Gln Gly 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile His Ser 
                85                  90                  95      


Arg Ser 
        


<210>  54
<211>  331
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (224)..(224)
<223>  n is a, c, g, or t

<400>  54
nctgctattc tgctatgggt atctggtgtt gacggagaca ttgcgatgac ccagtctcac       60

aaattcatgt ccacatcagt aggagacagg gtcagcatca cctgcaaggc cagtcaggat      120

gtgagtactg ctgtagcctg gtatcaacag aaaccaggac aatctcctaa actactgatt      180

tactcggcat cctaccggta cactggagtc cgtgatcgct tcantggcag tcgatgtggg      240

acggatttca ctttccccat cagcagtgtg cagggtgaag acctggcagt ttattactgt      300

cagcaacatt atagtatcca ttcacgttcg g                                     331


<210>  55
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  55

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr 
            100                 105         


<210>  56
<211>  344
<212>  DNA
<213>  Mus musculus

<400>  56
tggatccctg cttccagcag tgatgttttg atgacccaaa ctccactctc cctgcctgtc       60

agtcttggag atcaagcctc catctcttgc agatctagtc agagcattgt acatagtaat      120

ggaaacacct atttagaatg gtacctgcag aaaccaggcc agtctccaaa gctcctgatc      180

tacagagttt ccaaccgatt ttctggggtc ccagacaggt tcagtggcag tggatcaggg      240

acagatttca cactcaagat cagcagagtg gaggctgagg atctgggagt ttattactgc      300

tttcaaggtt cacatgttcc gtggacgttc ggtggaggca ccaa                       344


<210>  57
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Met Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Val Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  58
<211>  340
<212>  DNA
<213>  Mus musculus

<400>  58
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta tacagtggaa atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaaatgttga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacacattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca atttattact gtcagaatga ttatagttat      300

ccggtcacgt tcggtgctgg gaccaagctg gagctgaaac                            340


<210>  59
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  59

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Thr Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Leu Ile Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  60
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  60
gaaattgtgc tcactcagtc tccagccatc acagctgcat ctctggggca aaaggtcacc       60

atcacctgca gtgccagctc aagtgtaaat tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaccatggat ttatgaaata tccaaactgg cttctggagt cccagctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca tttattactg ccagcagtgg aattatcctc ttatcacgtt cggtgctggg      300

accaagctgg agctgaaac                                                   319


<210>  61
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  61

Glu Asn Ala Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ser Met Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Glu Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Phe Pro Val His 
                85                  90                  95      


Val Arg Arg Gly Asp Gln Val Gly Asn Lys Thr 
            100                 105         


<210>  62
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  62
gaaaatgctc tcacccagtc tccagcaatc atgtctgcat ctccagggga aaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaagc      120

atgtccccca aactctggat ttatgacaca tccaaactgg cttctggagt cccaggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gaggttgcca cttattactg ttttcagggg tagtgggttc ccagtacacg ttcggagggg      300

ggaccaagtt ggaaataaaa c                                                321


<210>  63
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Phe His Ala Arg Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Asn Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His Phe Trp Tyr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  64
<211>  322
<212>  DNA
<213>  Mus musculus

<400>  64
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactatcacc       60

atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag      120

ggaaaatctc ctcacctcct ggtctttcat gcaagatcct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca atatcaacag cctgcagcct      240

gaagattttg ggatttatta ctgtcaacat ttttggtata ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa ac                                               322


<210>  65
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Amd1.6Vh, CDR1

<400>  65

Gly Tyr Ser Phe Thr Asn Tyr Trp 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Amd1.6Vh, CDR2

<400>  66

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Amd1.6Vh, CDR3

<400>  67

Asp Asp Tyr Ser Arg Phe Ser Tyr 
1               5               


<210>  68
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Amd1.6Vl, CDR1

<400>  68

Gln Ser Val Ser Asn Asp 
1               5       


<210>  69
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Amd1.6Vl, CDR2

<400>  69

Tyr Thr Ser 
1           


<210>  70
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Amd2.1Vh, CDR1

<400>  70

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Amd2.1Vh, CDR2


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  71

Ile Ser Ser Gly Gly Ser Xaa Thr 
1               5               


<210>  72
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Amd2.1Vh, CDR3

<400>  72

Val Gly Leu Tyr Tyr Asp Tyr Tyr Tyr Ser Met Asp Tyr 
1               5                   10              


<210>  73
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Amd2.1Vl, CDR1

<400>  73

Gln Ser Leu Leu Tyr Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  74
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Amd2.1Vl, CDR2

<400>  74

Trp Ala Ser 
1           


