                         SEQUENCE LISTING

<110>  KING'S COLLEGE LONDON and GALDERMA RESEARCH & DEVELOPMENT
 
<120>  AP5B1 AS A NEW MARKER FOR MODERATE TO SEVERE ACNE

<130>  B1738PC00

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  6595
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(2637)

<400>  1
atg ggg ccc ctg agc cgg gac gcc tgg gcc cag cgc ttg ggg gcc ttc         48
Met Gly Pro Leu Ser Arg Asp Ala Trp Ala Gln Arg Leu Gly Ala Phe           
1               5                   10                  15                

cgg gcc agc ccg tct gcc ttc atg gca ggt ccc gag ggg gag gat ttg         96
Arg Ala Ser Pro Ser Ala Phe Met Ala Gly Pro Glu Gly Glu Asp Leu           
            20                  25                  30                    

ggt cgc gac ctg ctg agc gac ctg aga agt gag aag ctg agc gaa cag        144
Gly Arg Asp Leu Leu Ser Asp Leu Arg Ser Glu Lys Leu Ser Glu Gln           
        35                  40                  45                        

acc aag gtt tcc ctg ctg gcc ctg agc atg gag tac cct gcg cag ctg        192
Thr Lys Val Ser Leu Leu Ala Leu Ser Met Glu Tyr Pro Ala Gln Leu           
    50                  55                  60                            

tgg ccc gac gcc tct gcg gcc gaa gtg gcc gcc acc tcc ctg ttg gac        240
Trp Pro Asp Ala Ser Ala Ala Glu Val Ala Ala Thr Ser Leu Leu Asp           
65                  70                  75                  80            

acc ttg gtc ctc cta ccc ccg cgg ccc tca gct ctc cgt cgg cca ctg        288
Thr Leu Val Leu Leu Pro Pro Arg Pro Ser Ala Leu Arg Arg Pro Leu           
                85                  90                  95                

ctg ctg gcg gcc acc act gcc ctg gcg gcg ggc ggc gcg ctg ggc ccc        336
Leu Leu Ala Ala Thr Thr Ala Leu Ala Ala Gly Gly Ala Leu Gly Pro           
            100                 105                 110                   

acc tcg ggc gcc tcc tgc cgg ctc ctg ccc cta ctg ctc ggc ctg gcc        384
Thr Ser Gly Ala Ser Cys Arg Leu Leu Pro Leu Leu Leu Gly Leu Ala           
        115                 120                 125                       

gcg ggt agc gat ctg ggg cga ggc ttt gtc ccc gcc tcg gaa cag cgc        432
Ala Gly Ser Asp Leu Gly Arg Gly Phe Val Pro Ala Ser Glu Gln Arg           
    130                 135                 140                           

ccc ttg cag gcc acg gcc tgc gag tgc ctg cga gag cta gag agc tgc        480
Pro Leu Gln Ala Thr Ala Cys Glu Cys Leu Arg Glu Leu Glu Ser Cys           
145                 150                 155                 160           

aag ccc ggg ctg ctg ggg ggc tcc ctg ggg ttg ctg cgg ggc ctg ctg        528
Lys Pro Gly Leu Leu Gly Gly Ser Leu Gly Leu Leu Arg Gly Leu Leu           
                165                 170                 175               

ggg cag gaa ggc cct gtc cag cca ctc agc ctg ttg ctg gcc ctc gct        576
Gly Gln Glu Gly Pro Val Gln Pro Leu Ser Leu Leu Leu Ala Leu Ala           
            180                 185                 190                   

ttg cgc aac acc ttg gtg ctc cag tcc cgg gtt ggg gct ggc ctg ggg        624
Leu Arg Asn Thr Leu Val Leu Gln Ser Arg Val Gly Ala Gly Leu Gly           
        195                 200                 205                       

gga ctg ctc acg gat aag gtc tcc cca act ggg ggt ggt ccc tgg gat        672
Gly Leu Leu Thr Asp Lys Val Ser Pro Thr Gly Gly Gly Pro Trp Asp           
    210                 215                 220                           

tgg aca cta gtg gag gag ggc gat gga cgc ctt cag ccc cag gca ccc        720
Trp Thr Leu Val Glu Glu Gly Asp Gly Arg Leu Gln Pro Gln Ala Pro           
225                 230                 235                 240           

agc tgg ccg gca gct gag gag gga gag ggg gag cgt agc ctt aca gca        768
Ser Trp Pro Ala Ala Glu Glu Gly Glu Gly Glu Arg Ser Leu Thr Ala           
                245                 250                 255               

cga gag cac agc cct gag gag gcg cgg gag ctg cgg gct gcg gtg atc        816
Arg Glu His Ser Pro Glu Glu Ala Arg Glu Leu Arg Ala Ala Val Ile           
            260                 265                 270                   

cag ctt ctg gac acc tcc tat ctg ctc act cct gtg gcc cag gcc cag        864
Gln Leu Leu Asp Thr Ser Tyr Leu Leu Thr Pro Val Ala Gln Ala Gln           
        275                 280                 285                       

ctc ctg tgg ctg ctg ggc tgg gcc ctg cgg ggt ctg cag gga cag cca        912
Leu Leu Trp Leu Leu Gly Trp Ala Leu Arg Gly Leu Gln Gly Gln Pro           
    290                 295                 300                           

ccg gca ctc ttc aag ccg cag ctg gta cgg ctg cta ggc aca gca cag        960
Pro Ala Leu Phe Lys Pro Gln Leu Val Arg Leu Leu Gly Thr Ala Gln           
305                 310                 315                 320           

ctg aca ctg ttg cac gcc atg ctt gcg ctc aag gcg gcc ttt ggt gag       1008
Leu Thr Leu Leu His Ala Met Leu Ala Leu Lys Ala Ala Phe Gly Glu           
                325                 330                 335               

gcc ttg ttc aca gcc cag gat gaa gcg ttg ctg ctc cgc cgg ctc acc       1056
Ala Leu Phe Thr Ala Gln Asp Glu Ala Leu Leu Leu Arg Arg Leu Thr           
            340                 345                 350                   

ttg gct gcc cag cac cct gct ctg cct ccg ccc acc cat ctc ttt tac       1104
Leu Ala Ala Gln His Pro Ala Leu Pro Pro Pro Thr His Leu Phe Tyr           
        355                 360                 365                       

ctt cac tgc gtc ctg agc ttc cct gag aac tgg ccg ctg ggc cct gaa       1152
Leu His Cys Val Leu Ser Phe Pro Glu Asn Trp Pro Leu Gly Pro Glu           
    370                 375                 380                           

ggt gag gag gct gcc cca ctg ctg cta ggg ccc cag cta tgc cgt ggt       1200
Gly Glu Glu Ala Ala Pro Leu Leu Leu Gly Pro Gln Leu Cys Arg Gly           
385                 390                 395                 400           

ctc ctg ccc agt ctc ctg cat gac cca atg gcc ctc ctg gcc cgc ctg       1248
Leu Leu Pro Ser Leu Leu His Asp Pro Met Ala Leu Leu Ala Arg Leu           
                405                 410                 415               

cat tta ctg tgc ctg ctc tgt gcc gag gag gaa gaa gag gag aaa ggc       1296
His Leu Leu Cys Leu Leu Cys Ala Glu Glu Glu Glu Glu Glu Lys Gly           
            420                 425                 430                   

cag ctt cca agc cca cgg cac tac ctg gaa gag ctg ctg gct ggc ttg       1344
Gln Leu Pro Ser Pro Arg His Tyr Leu Glu Glu Leu Leu Ala Gly Leu           
        435                 440                 445                       

cgg cag cgg gca gcc ctg gat ggg ggc ccc cgg gcc ttg gcc act ctc       1392
Arg Gln Arg Ala Ala Leu Asp Gly Gly Pro Arg Ala Leu Ala Thr Leu           
    450                 455                 460                           

tgc ttc cag gcc tcg tat ctg gtg gcc tgc tgc ctg gct ggg caa cct       1440
Cys Phe Gln Ala Ser Tyr Leu Val Ala Cys Cys Leu Ala Gly Gln Pro           
465                 470                 475                 480           

acg gtg ctg acc ccc ttg atc cac gga ctg gcc cag ctg tac caa gcc       1488
Thr Val Leu Thr Pro Leu Ile His Gly Leu Ala Gln Leu Tyr Gln Ala           
                485                 490                 495               

cgg ccc atg ctg gct ccc cac ttt gtg gac ctc ttg gat cag gtg gac       1536
Arg Pro Met Leu Ala Pro His Phe Val Asp Leu Leu Asp Gln Val Asp           
            500                 505                 510                   

tct gag ctg agg gag ccc ctg aag gtg gtg ttg cgg cag gtg gtg gtg       1584
Ser Glu Leu Arg Glu Pro Leu Lys Val Val Leu Arg Gln Val Val Val           
        515                 520                 525                       

tcc agg ccg ggc agg gat gaa gct ctt tgc tgg cac ctg caa atg ctg       1632
Ser Arg Pro Gly Arg Asp Glu Ala Leu Cys Trp His Leu Gln Met Leu           
    530                 535                 540                           

gca aag gtg gca gat gga gat gcc cag agt gct acc ctc aac ttt cta       1680
Ala Lys Val Ala Asp Gly Asp Ala Gln Ser Ala Thr Leu Asn Phe Leu           
545                 550                 555                 560           

cag gcc gcg gct gcc cac tgc acg aac tgg gac cta cag cag ggc ctg       1728
Gln Ala Ala Ala Ala His Cys Thr Asn Trp Asp Leu Gln Gln Gly Leu           
                565                 570                 575               

ctg cgg gtc tgc cgg gcg ctg ctg cgg gca ggg gtg agg ggc ggc ctg       1776
Leu Arg Val Cys Arg Ala Leu Leu Arg Ala Gly Val Arg Gly Gly Leu           
            580                 585                 590                   

gtc gac ttg ctg cag gtg ctg gcc agg cag ctg gag gac cct gat ggg       1824
Val Asp Leu Leu Gln Val Leu Ala Arg Gln Leu Glu Asp Pro Asp Gly           
        595                 600                 605                       

cgt gac cac gcc cgc ctc tac tac atc ctg ctg gca cac ctg gca gca       1872
Arg Asp His Ala Arg Leu Tyr Tyr Ile Leu Leu Ala His Leu Ala Ala           
    610                 615                 620                           

ccc aag ttg ggg gtg gcc ctg ggc ccc tcg ctt gcc gca cct gca ctg       1920
Pro Lys Leu Gly Val Ala Leu Gly Pro Ser Leu Ala Ala Pro Ala Leu           
625                 630                 635                 640           

gcc tct tca ctg gtg gcc gag aac cag ggc ttt gtg gca gca ctg atg       1968
Ala Ser Ser Leu Val Ala Glu Asn Gln Gly Phe Val Ala Ala Leu Met           
                645                 650                 655               

gtg cag gag gca ccg gcc ctg gta cgg ctg agc ctg ggg tcc cat cgg       2016
Val Gln Glu Ala Pro Ala Leu Val Arg Leu Ser Leu Gly Ser His Arg           
            660                 665                 670                   

gtc aag ggc cca ctc cca gtg ttg aag ctc cag ccg gag gcg ctg gag       2064
Val Lys Gly Pro Leu Pro Val Leu Lys Leu Gln Pro Glu Ala Leu Glu           
        675                 680                 685                       

ccc atc tac tct ctg gag ctg cgc ttc cgt gtg gaa gga cag ctg tat       2112
Pro Ile Tyr Ser Leu Glu Leu Arg Phe Arg Val Glu Gly Gln Leu Tyr           
    690                 695                 700                           

gca ccc ctg gag gct gtc cat gtg ccc tgc ctg tgt cct ggc cgc cct       2160
Ala Pro Leu Glu Ala Val His Val Pro Cys Leu Cys Pro Gly Arg Pro           
705                 710                 715                 720           

gcc cgc cct ctg ctc ctg cct ctg cag ccc cga tgc ccg gcc ccc gca       2208
Ala Arg Pro Leu Leu Leu Pro Leu Gln Pro Arg Cys Pro Ala Pro Ala           
                725                 730                 735               

cgg ctg gat gtc cat gcc ctt tac acc aca tcc act ggt ctc acg tgc       2256
Arg Leu Asp Val His Ala Leu Tyr Thr Thr Ser Thr Gly Leu Thr Cys           
            740                 745                 750                   

cat gcc cac ttg cca ccc ctg ttc gtg aac ttt gcc gac ctc ttt ctg       2304
His Ala His Leu Pro Pro Leu Phe Val Asn Phe Ala Asp Leu Phe Leu           
        755                 760                 765                       

cct ttc ccg cag cct cca gag ggg gcc ggg ctg ggc ttc ttt gag gag       2352
Pro Phe Pro Gln Pro Pro Glu Gly Ala Gly Leu Gly Phe Phe Glu Glu           
    770                 775                 780                           

ctc tgg gat tcc tgc ctg cca gag ggt gct gag agt cgt gtg tgg tgt       2400
Leu Trp Asp Ser Cys Leu Pro Glu Gly Ala Glu Ser Arg Val Trp Cys           
785                 790                 795                 800           

cca ctt ggg cca cag ggc ctg gag ggc ttg gtg tcc cgc cac ctg gag       2448
Pro Leu Gly Pro Gln Gly Leu Glu Gly Leu Val Ser Arg His Leu Glu           
                805                 810                 815               

cct ttt gtg gtg gtg gcc cag cct cct acc agc tac tgt gta gca atc       2496
Pro Phe Val Val Val Ala Gln Pro Pro Thr Ser Tyr Cys Val Ala Ile           
            820                 825                 830                   

cac ctg ccc ccg gac tca aag ctg ctg ctg cgg ctg gag gcg gcc ctg       2544
His Leu Pro Pro Asp Ser Lys Leu Leu Leu Arg Leu Glu Ala Ala Leu           
        835                 840                 845                       

gca gat gga gtg cct gtg gcc ctg cgg acc gat gac tgg gcc gtg ctg       2592
Ala Asp Gly Val Pro Val Ala Leu Arg Thr Asp Asp Trp Ala Val Leu           
    850                 855                 860                           

ccc ctg gcg ggg gac tac ctc cgt ggg ctg gcg gct gct gtc tga           2637
Pro Leu Ala Gly Asp Tyr Leu Arg Gly Leu Ala Ala Ala Val                   
865                 870                 875                               

gccccgggag accaggtggg ggcaggactg tggcccttgt gggggccaag gcacactcct     2697

gtagctctgt cgccaaaacc ctgcattccg cagtgccctc gctggcttgt tttcttttgg     2757

gccccggttg ggagcaggct cctgggggtg agggtctgtc tgagtctgtt tttgctgctc     2817

tagcaagatc cctgagacgg ggtaagttat aataaacaga aatgtattgg ctcagagctc     2877

tggaggctgg gaagtccata gtggagggcc cagagcccag tgaggaccct tctgcatctt     2937

cccatgacag aggacagagt gacaggagtg aggggagaga gcgaacccac tcccaagata     2997

acggcctgag tccacgcagg agggcagagc cctcgtggcc tgaccacctc ttagggtcta     3057

atcttatact gttacagtgg caatcgcatt tcaacgtgag cgtgggaggg gacaaacatt     3117

caaaccatag cagggtcata ggccccaaga aggcttccag acagaacccg gcactgtaga     3177

gctacagagt tccttctcac ccagacacac tagtgctctc cagaatctct gcccaggagg     3237

caggggaaaa atctcctttc tgcttcccag agagggtctg gccttgccca aggccactca     3297

gtgatttagg aagaaggctg aagctagagt gtggacctga cctgttggac agtacttttc     3357

tttctttttt tttcggggag gggttaaaga caggatctca ctctggcgct ctggagtgca     3417

gtggtgtgat tagggatcat tgcagactct gcctctcagg ctcaggtgat cctcccatct     3477

cagcctgcct ccgagtagct gggactacag gtgtgagtca ccactgtatt ttttgcagac     3537

aggatctccc tgtttcctag gctggtctcg aactcctggg cttaaatgac tcttctgcct     3597

cagcctcacc aaagtgttgg gattactggt gtgagccccc acacctggcc gagccagcgc     3657

ttctcaactc ccaaggtttg caagctccct gccccaggga gctcacgcca ggcaggccag     3717

tgggcctaag ccagaaacag aaagacagca gtggccaggt ggagagcttc ccaagctgtg     3777

ccgattagag ccagctctag gaagggcctg ctaataaggt ctagggtctg agaccaagtt     3837

ttttctaatc tcagccccta agaaacctaa tttgtgctta ggaatcttcc caggtaagaa     3897

gaactagttc ctctagttgt tgtttttttt tcccaaacat gcaaacactg aggattgagc     3957

tgtgtggggt cagctgtgct gccaggcaca tgtacgttgc ctcatttcat ccttgcaaca     4017

gctctgcagg gccccgcaga tgaggaaatc cgtaggcagg agcggttgag tgattttcct     4077

aaggtcaccc agctgtttgg taatagtgtt ttgtcatctg gtagcaggtt tccattacca     4137

tgccatcaga gcagacctca gccagggcca cagaggtccc aaccgtctct gccctcttct     4197

gctgcccctg cctcatgggc tcccagccac aggttcccca tgggccagct ttacgcctcc     4257

tgatccttcc gattggggca gactaggaga ggaaagacgg gcctgggctg ggtgcggtgg     4317

ctcatgcctg taatcccagc actttgagag gctgcggcgg gtggatcacc tgaggccagg     4377

tgtttgagat cagcctggcc agcatggcga aaccctgtgt ctaataaaaa tacaaaaatt     4437

agccgggcgt ggtggcgggc gcctgtaatc ccagctactt gggaggctga ggcaggagaa     4497

ttacttgaac ctgggaggca gaagttgcag tgagccgaga tcacgccact gcactccagc     4557

ctgggcgaca gagcaaggct ctgtctcaaa aaaagaaaaa aaagaaaggg cctgggacag     4617

tggtactgtt aataggtgga gtcaggaggc ctgtctcaaa cttgagatgt ggcaataact     4677

tgctttgtca cctcggcaag tcatttccaa atcaggaagg ggtcagtttc aggaaacaga     4737

aacttctcca gctgtttttg gcagaagggg atttaaggga atcagggtac ttaaagtaca     4797

tgggaaggct ggagaagtcg cctccaggaa gctcccactg gagctgggat cagaacgtac     4857

tgtcctgcct gccatcccct gtaagcaccc aggaagctgg gcttgggccc tgggacatgg     4917

ggtgggactg ccactcctgc ctcctgacac ccacaaagcc agaagcgtgg tgctgctgca     4977

gaaggactga acatctccaa ggctgggccc gcagagcaaa cttccttggc cctgtgtcct     5037

ccatccatat ccttcaaagg acacctcatt agtggactcc atttctctct tccacggaac     5097

tccagtggca agggaatcca gaaacgtttt ctttttgcct ggagatgcta atccttagcc     5157

taagaataag gaaactggtc catgtaagga ctgaccatcc tttcacccat ctgtctgccc     5217

acttgtgcat ccatcccatt ttatccatcc attcctccag ttgtggacac cagatgactt     5277

tcagctcccc ctaccccaac cagaactttg ctgcaatggc cattcttata tgcccctatg     5337

gacccatggg acaattctct gggatacatg ctaggagcag aattgctgaa tcatagggaa     5397

tgcatgtgct tagcttggct aagcaatgtt ggagtaaaag cttttggttt tgcatcttct     5457

cagcacttct agggaggcac caaaagggag gatggcactg actgagccca cctgagatag     5517

ctcctagacc ccagccctct gtgtcctcag aatcacacac tgctgctcat cacttcagct     5577

tcccgaagat catggcaata gcagcatgcc tgtaactgtc ccaagtacaa ccaaaaattc     5637

ttcctaaaga gagggaacca aagtcacacg ggtcaccttg tccacctgtg tggacgttgc     5697

tcatgttcac atacccttcc ttgcctcctt caaggcaggt ctggccacaa gcccagctct     5757

ggctaatgaa atgtgaaggg agtcaagggc cgggggcggt ggctcacacc tgtaatccca     5817

gcattttggg aggccgaggt gggttgatta cctgaggtga agaatttgag accagcctgg     5877

ccaacatggt gaaacccgtc tctactaaaa atccaaaaat tagccgggtg tggtggcgtg     5937

ctcataatcc cagctactca ggaggctgag gcaggagaat cgcttgaacc cgggaggtgg     5997

aggttgcagt gaactgagat tgggccacta cactccagcc tggatgacag agcaggactc     6057

cgtctcaaaa aagaaaaaag aaatgtgaag gggtcagttt tggggcaaaa tatgtcattg     6117

ccagtgctca attttccagc cctctcttcc tctgccatga ccgttgggga agtacatgtt     6177

gagatggagg tgctaaatag ttgagtcata atctcacctg gatacgctgt aacaaatgcc     6237

ctggattatc aaatcagtta tgtaaactaa aaatcctaaa accccaccga ctgaacagat     6297

gccacctcgt ggccgaggga atctcagaaa aaacttaaaa caattcctgg ccctgatggg     6357

ttgggaggtc agatgcaact tgttataccc catcccttta tggtttagac acagctgccg     6417

agcatgaatg aacaaaatag ggatcatgag atggacagaa cagacactgt ggcaataaga     6477

taccaaattg taaacaggac ctaaggccat gccaagcaag ggttaagtca tgtagagccc     6537

accttcatgc cccgcctccc ctgcccccaa cttatgaata aactatgttc taactgca       6595


<210>  2
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Leu Ser Arg Asp Ala Trp Ala Gln Arg Leu Gly Ala Phe 
1               5                   10                  15      


Arg Ala Ser Pro Ser Ala Phe Met Ala Gly Pro Glu Gly Glu Asp Leu 
            20                  25                  30          


Gly Arg Asp Leu Leu Ser Asp Leu Arg Ser Glu Lys Leu Ser Glu Gln 
        35                  40                  45              


Thr Lys Val Ser Leu Leu Ala Leu Ser Met Glu Tyr Pro Ala Gln Leu 
    50                  55                  60                  


Trp Pro Asp Ala Ser Ala Ala Glu Val Ala Ala Thr Ser Leu Leu Asp 
65                  70                  75                  80  


Thr Leu Val Leu Leu Pro Pro Arg Pro Ser Ala Leu Arg Arg Pro Leu 
                85                  90                  95      


Leu Leu Ala Ala Thr Thr Ala Leu Ala Ala Gly Gly Ala Leu Gly Pro 
            100                 105                 110         


Thr Ser Gly Ala Ser Cys Arg Leu Leu Pro Leu Leu Leu Gly Leu Ala 
        115                 120                 125             


Ala Gly Ser Asp Leu Gly Arg Gly Phe Val Pro Ala Ser Glu Gln Arg 
    130                 135                 140                 


Pro Leu Gln Ala Thr Ala Cys Glu Cys Leu Arg Glu Leu Glu Ser Cys 
145                 150                 155                 160 


Lys Pro Gly Leu Leu Gly Gly Ser Leu Gly Leu Leu Arg Gly Leu Leu 
                165                 170                 175     


Gly Gln Glu Gly Pro Val Gln Pro Leu Ser Leu Leu Leu Ala Leu Ala 
            180                 185                 190         


Leu Arg Asn Thr Leu Val Leu Gln Ser Arg Val Gly Ala Gly Leu Gly 
        195                 200                 205             


Gly Leu Leu Thr Asp Lys Val Ser Pro Thr Gly Gly Gly Pro Trp Asp 
    210                 215                 220                 


Trp Thr Leu Val Glu Glu Gly Asp Gly Arg Leu Gln Pro Gln Ala Pro 
225                 230                 235                 240 


Ser Trp Pro Ala Ala Glu Glu Gly Glu Gly Glu Arg Ser Leu Thr Ala 
                245                 250                 255     


Arg Glu His Ser Pro Glu Glu Ala Arg Glu Leu Arg Ala Ala Val Ile 
            260                 265                 270         


Gln Leu Leu Asp Thr Ser Tyr Leu Leu Thr Pro Val Ala Gln Ala Gln 
        275                 280                 285             


Leu Leu Trp Leu Leu Gly Trp Ala Leu Arg Gly Leu Gln Gly Gln Pro 
    290                 295                 300                 


Pro Ala Leu Phe Lys Pro Gln Leu Val Arg Leu Leu Gly Thr Ala Gln 
305                 310                 315                 320 


Leu Thr Leu Leu His Ala Met Leu Ala Leu Lys Ala Ala Phe Gly Glu 
                325                 330                 335     


Ala Leu Phe Thr Ala Gln Asp Glu Ala Leu Leu Leu Arg Arg Leu Thr 
            340                 345                 350         


Leu Ala Ala Gln His Pro Ala Leu Pro Pro Pro Thr His Leu Phe Tyr 
        355                 360                 365             


Leu His Cys Val Leu Ser Phe Pro Glu Asn Trp Pro Leu Gly Pro Glu 
    370                 375                 380                 


Gly Glu Glu Ala Ala Pro Leu Leu Leu Gly Pro Gln Leu Cys Arg Gly 
385                 390                 395                 400 


Leu Leu Pro Ser Leu Leu His Asp Pro Met Ala Leu Leu Ala Arg Leu 
                405                 410                 415     


His Leu Leu Cys Leu Leu Cys Ala Glu Glu Glu Glu Glu Glu Lys Gly 
            420                 425                 430         


Gln Leu Pro Ser Pro Arg His Tyr Leu Glu Glu Leu Leu Ala Gly Leu 
        435                 440                 445             


Arg Gln Arg Ala Ala Leu Asp Gly Gly Pro Arg Ala Leu Ala Thr Leu 
    450                 455                 460                 


Cys Phe Gln Ala Ser Tyr Leu Val Ala Cys Cys Leu Ala Gly Gln Pro 
465                 470                 475                 480 


Thr Val Leu Thr Pro Leu Ile His Gly Leu Ala Gln Leu Tyr Gln Ala 
                485                 490                 495     


Arg Pro Met Leu Ala Pro His Phe Val Asp Leu Leu Asp Gln Val Asp 
            500                 505                 510         


Ser Glu Leu Arg Glu Pro Leu Lys Val Val Leu Arg Gln Val Val Val 
        515                 520                 525             


Ser Arg Pro Gly Arg Asp Glu Ala Leu Cys Trp His Leu Gln Met Leu 
    530                 535                 540                 


Ala Lys Val Ala Asp Gly Asp Ala Gln Ser Ala Thr Leu Asn Phe Leu 
545                 550                 555                 560 


Gln Ala Ala Ala Ala His Cys Thr Asn Trp Asp Leu Gln Gln Gly Leu 
                565                 570                 575     


Leu Arg Val Cys Arg Ala Leu Leu Arg Ala Gly Val Arg Gly Gly Leu 
            580                 585                 590         


Val Asp Leu Leu Gln Val Leu Ala Arg Gln Leu Glu Asp Pro Asp Gly 
        595                 600                 605             


Arg Asp His Ala Arg Leu Tyr Tyr Ile Leu Leu Ala His Leu Ala Ala 
    610                 615                 620                 


Pro Lys Leu Gly Val Ala Leu Gly Pro Ser Leu Ala Ala Pro Ala Leu 
625                 630                 635                 640 


Ala Ser Ser Leu Val Ala Glu Asn Gln Gly Phe Val Ala Ala Leu Met 
                645                 650                 655     


Val Gln Glu Ala Pro Ala Leu Val Arg Leu Ser Leu Gly Ser His Arg 
            660                 665                 670         


Val Lys Gly Pro Leu Pro Val Leu Lys Leu Gln Pro Glu Ala Leu Glu 
        675                 680                 685             


Pro Ile Tyr Ser Leu Glu Leu Arg Phe Arg Val Glu Gly Gln Leu Tyr 
    690                 695                 700                 


Ala Pro Leu Glu Ala Val His Val Pro Cys Leu Cys Pro Gly Arg Pro 
705                 710                 715                 720 


Ala Arg Pro Leu Leu Leu Pro Leu Gln Pro Arg Cys Pro Ala Pro Ala 
                725                 730                 735     


Arg Leu Asp Val His Ala Leu Tyr Thr Thr Ser Thr Gly Leu Thr Cys 
            740                 745                 750         


His Ala His Leu Pro Pro Leu Phe Val Asn Phe Ala Asp Leu Phe Leu 
        755                 760                 765             


Pro Phe Pro Gln Pro Pro Glu Gly Ala Gly Leu Gly Phe Phe Glu Glu 
    770                 775                 780                 


Leu Trp Asp Ser Cys Leu Pro Glu Gly Ala Glu Ser Arg Val Trp Cys 
785                 790                 795                 800 


Pro Leu Gly Pro Gln Gly Leu Glu Gly Leu Val Ser Arg His Leu Glu 
                805                 810                 815     


Pro Phe Val Val Val Ala Gln Pro Pro Thr Ser Tyr Cys Val Ala Ile 
            820                 825                 830         


His Leu Pro Pro Asp Ser Lys Leu Leu Leu Arg Leu Glu Ala Ala Leu 
        835                 840                 845             


Ala Asp Gly Val Pro Val Ala Leu Arg Thr Asp Asp Trp Ala Val Leu 
    850                 855                 860                 


Pro Leu Ala Gly Asp Tyr Leu Arg Gly Leu Ala Ala Ala Val 
865                 870                 875             


