                         SEQUENCE LISTING

<110>  Intervet International B.V.
       Morsey, Mohamad
       Zhang, Yuanzheng
       Bartels-Morozov, Denise
       Erskine, Jason
       Tarpey, Ian
 
<120>  Antibodies Against Canine PD-1

<130>  23705

<150>  61/918946
<151>  2013-12-20

<150>  61/918847
<151>  2013-12-20

<150>  62/030812
<151>  2014-07-30

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  795
<212>  DNA
<213>  Canis familiaris

<400>  1
ctagactccc ctgacaggcc ctggagcccg ctcaccttct ccccggcgca gctcacggtg       60

caggagggag agaacgccac gttcacctgc agcctggccg acatccccga cagcttcgtg      120

ctcaactggt accgcctgag cccccgcaac cagacggaca agctggccgc cttccaggag      180

gaccgcatcg agccgggccg ggacaggcgc ttccgcgtca tgcggctgcc caacgggcgg      240

gacttccaca tgagcatcgt cgctgcgcgc ctcaacgaca gcggcatcta cctgtgcggg      300

gccatctacc tgccccccaa cacacagatc aacgagagtc cccgcgcaga gctctccgtg      360

acggagagaa ccctggagcc ccccacacag agccccagcc ccccacccag actcagcggc      420

cagttgcagg ggctggtcat cggcgtcacg agcgtgctgg tgggtgtcct gctactgctg      480

ctgctgacct gggtcctggc cgctgtcttc cccagggcca cccgaggtgc ctgtgtgtgc      540

gggagcgagg acgagcctct gaaggagggc cccgatgcag cgcccgtctt caccctggac      600

tacggggagc tggacttcca gtggcgagag aagacgccgg agcccccggc gccctgtgcc      660

ccggagcaga ccgagtatgc caccatcgtc ttcccgggca ggccggcgtc cccgggccgc      720

agggcctcgg ccagcagcct gcagggagcc cagcctccga gccccgagga cggacccggc      780

ctgtggcccc tctga                                                       795


<210>  2
<211>  264
<212>  PRT
<213>  Canis familiaris

<400>  2

Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala 
1               5                   10                  15      


Gln Leu Thr Val Gln Glu Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ala Asp Ile Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro 
        35                  40                  45              


Arg Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu 
    50                  55                  60                  


Pro Gly Arg Asp Arg Arg Phe Arg Val Met Arg Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Ile Val Ala Ala Arg Leu Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu 
            100                 105                 110         


Ser Pro Arg Ala Glu Leu Ser Val Thr Glu Arg Thr Leu Glu Pro Pro 
        115                 120                 125             


Thr Gln Ser Pro Ser Pro Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly 
    130                 135                 140                 


Leu Val Ile Gly Val Thr Ser Val Leu Val Gly Val Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Thr Trp Val Leu Ala Ala Val Phe Pro Arg Ala Thr Arg Gly 
                165                 170                 175     


Ala Cys Val Cys Gly Ser Glu Asp Glu Pro Leu Lys Glu Gly Pro Asp 
            180                 185                 190         


Ala Ala Pro Val Phe Thr Leu Asp Tyr Gly Glu Leu Asp Phe Gln Trp 
        195                 200                 205             


Arg Glu Lys Thr Pro Glu Pro Pro Ala Pro Cys Ala Pro Glu Gln Thr 
    210                 215                 220                 


Glu Tyr Ala Thr Ile Val Phe Pro Gly Arg Pro Ala Ser Pro Gly Arg 
225                 230                 235                 240 


Arg Ala Ser Ala Ser Ser Leu Gln Gly Ala Gln Pro Pro Ser Pro Glu 
                245                 250                 255     


Asp Gly Pro Gly Leu Trp Pro Leu 
            260                 


<210>  3
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized

<400>  3
ctggattccc ccgacagacc ctggagccct ctcaccttct cccctgccca gctgaccgtc       60

caggaaggcg agaatgccac cttcacctgc agcctcgccg acatccccga cagcttcgtg      120

ctgaactggt acagactgag ccccaggaac cagaccgaca agctggccgc tttccaggag      180

gacaggatcg aacccggcag ggacaggagg tttagggtca tgaggctgcc caacggcagg      240

gacttccaca tgtccatcgt ggccgccaga ctgaacgact ccggcatcta cctgtgcggc      300

gctatctacc tgccccccaa cacccagatc aacgagagcc ccagggccga actgagcgtg      360

acagagagaa ccctggaacc tcccacccag agcccttccc ctcctcctag actgagcgga      420

cagctgcagg gcctggtg                                                    438


<210>  4
<211>  438
<212>  PRT
<213>  Canis familiaris

<400>  4

Cys Thr Gly Gly Ala Thr Thr Cys Cys Cys Cys Cys Gly Ala Cys Ala 
1               5                   10                  15      


Gly Ala Cys Cys Cys Thr Gly Gly Ala Gly Cys Cys Cys Thr Cys Thr 
            20                  25                  30          


Cys Ala Cys Cys Thr Thr Cys Thr Cys Cys Cys Cys Thr Gly Cys Cys 
        35                  40                  45              


Cys Ala Gly Cys Thr Gly Ala Cys Cys Gly Thr Cys Cys Ala Gly Gly 
    50                  55                  60                  


Ala Ala Gly Gly Cys Gly Ala Gly Ala Ala Thr Gly Cys Cys Ala Cys 
65                  70                  75                  80  


Cys Thr Thr Cys Ala Cys Cys Thr Gly Cys Ala Gly Cys Cys Thr Cys 
                85                  90                  95      


Gly Cys Cys Gly Ala Cys Ala Thr Cys Cys Cys Cys Gly Ala Cys Ala 
            100                 105                 110         


Gly Cys Thr Thr Cys Gly Thr Gly Cys Thr Gly Ala Ala Cys Thr Gly 
        115                 120                 125             


Gly Thr Ala Cys Ala Gly Ala Cys Thr Gly Ala Gly Cys Cys Cys Cys 
    130                 135                 140                 


Ala Gly Gly Ala Ala Cys Cys Ala Gly Ala Cys Cys Gly Ala Cys Ala 
145                 150                 155                 160 


Ala Gly Cys Thr Gly Gly Cys Cys Gly Cys Thr Thr Thr Cys Cys Ala 
                165                 170                 175     


Gly Gly Ala Gly Gly Ala Cys Ala Gly Gly Ala Thr Cys Gly Ala Ala 
            180                 185                 190         


Cys Cys Cys Gly Gly Cys Ala Gly Gly Gly Ala Cys Ala Gly Gly Ala 
        195                 200                 205             


Gly Gly Thr Thr Thr Ala Gly Gly Gly Thr Cys Ala Thr Gly Ala Gly 
    210                 215                 220                 


Gly Cys Thr Gly Cys Cys Cys Ala Ala Cys Gly Gly Cys Ala Gly Gly 
225                 230                 235                 240 


Gly Ala Cys Thr Thr Cys Cys Ala Cys Ala Thr Gly Thr Cys Cys Ala 
                245                 250                 255     


Thr Cys Gly Thr Gly Gly Cys Cys Gly Cys Cys Ala Gly Ala Cys Thr 
            260                 265                 270         


Gly Ala Ala Cys Gly Ala Cys Thr Cys Cys Gly Gly Cys Ala Thr Cys 
        275                 280                 285             


Thr Ala Cys Cys Thr Gly Thr Gly Cys Gly Gly Cys Gly Cys Thr Ala 
    290                 295                 300                 


Thr Cys Thr Ala Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys Ala Ala 
305                 310                 315                 320 


Cys Ala Cys Cys Cys Ala Gly Ala Thr Cys Ala Ala Cys Gly Ala Gly 
                325                 330                 335     


Ala Gly Cys Cys Cys Cys Ala Gly Gly Gly Cys Cys Gly Ala Ala Cys 
            340                 345                 350         


Thr Gly Ala Gly Cys Gly Thr Gly Ala Cys Ala Gly Ala Gly Ala Gly 
        355                 360                 365             


Ala Ala Cys Cys Cys Thr Gly Gly Ala Ala Cys Cys Thr Cys Cys Cys 
    370                 375                 380                 


Ala Cys Cys Cys Ala Gly Ala Gly Cys Cys Cys Thr Thr Cys Cys Cys 
385                 390                 395                 400 


Cys Thr Cys Cys Thr Cys Cys Thr Ala Gly Ala Cys Thr Gly Ala Gly 
                405                 410                 415     


Cys Gly Gly Ala Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly Gly Cys 
            420                 425                 430         


Cys Thr Gly Gly Thr Gly 
        435             


<210>  5
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized canine and human

<400>  5
ctggattccc ccgacagacc ctggagccct ctcaccttct cccctgccca gctgaccgtc       60

caggaaggcg agaatgccac cttcacctgc agcctcgccg acatccccga cagcttcgtg      120

ctgaactggt acagactgag ccccaggaac cagaccgaca agctggccgc tttccaggag      180

gacaggatcg aacccggcag ggacaggagg tttagggtca tgaggctgcc caacggcagg      240

gacttccaca tgtccatcgt ggccgccaga ctgaacgact ccggcatcta cctgtgcggc      300

gctatctacc tgccccccaa cacccagatc aacgagagcc ccagggccga actgagcgtg      360

acagagagaa ccctggaacc tcccacccag agcccttccc ctcctcctag actgagcgga      420

cagctgcagg gcctggtggg taccgacaaa actcacacat gcccaccgtg cccagcacct      480

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      540

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      600

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      660

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      720

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      780

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      840

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      900

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      960

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1020

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1080

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  1128


<210>  6
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  6

Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala 
1               5                   10                  15      


Gln Leu Thr Val Gln Glu Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu 
            20                  25                  30          


Ala Asp Ile Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro 
        35                  40                  45              


Arg Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu 
    50                  55                  60                  


Pro Gly Arg Asp Arg Arg Phe Arg Val Met Arg Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Ile Val Ala Ala Arg Leu Asn Asp Ser Gly Ile 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu 
            100                 105                 110         


Ser Pro Arg Ala Glu Leu Ser Val Thr Glu Arg Thr Leu Glu Pro Pro 
        115                 120                 125             


Thr Gln Ser Pro Ser Pro Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly 
    130                 135                 140                 


Leu Val Gly Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210>  7
<211>  816
<212>  DNA
<213>  Canis familiaris

<400>  7
tttacgatca cagtttctaa ggacctgtat gtggtagagt atggtggcaa tgtgacaatg       60

gaatgcaaat tcccggtgga aaaacagtta aacttgtttg cactaatcgt ctactgggaa      120

atggaggata aaaaaattat acaatttgtg aatggaaagg aagacctgaa agttcagcac      180

agcagctaca gccagagggc tcagctattg aaggaccagc tcttcttggg gaaggctgcg      240

cttcagatca cagatgtgag attgcaggat gcaggggttt actgctgctt gatcggctat      300

ggcggtgctg actacaagcg gattactttg aaagttcatg ccccgtaccg caacatcagc      360

caaagaattt ctgtggatcc tgtcacctct gaacatgaac taatgtgtca ggctgagggt      420

taccctgagg ctgaagtcat ctggacaagc agtgaccacc gagtcctgag tggcaaaacc      480

accatcacta attccaatag ggaagagaag cttttcaatg tgaccagcac gctgaacatc      540

aatgcaacag ctaatgagat tttctactgc acttttcaaa gatcaggtcc tgaggaaaac      600

aatactgccg agttggtcat cccagaacga ctgcccgttc cagcaagtga gaggactcat      660

ttcatgattc tgggaccttt cctgttgctt cttggtgtag tcctggcagt cactttctgt      720

ctaaaaaaac atgggagaat gatggatgtg gaaaaatgtt gcacccgaga taggaactca      780

aagaaacgaa atgatataca atttgaagag acataa                                816


<210>  8
<211>  271
<212>  PRT
<213>  Canis familiaris

<400>  8

Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asn Leu 
            20                  25                  30          


Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His Phe Met Ile Leu 
    210                 215                 220                 


Gly Pro Phe Leu Leu Leu Leu Gly Val Val Leu Ala Val Thr Phe Cys 
225                 230                 235                 240 


Leu Lys Lys His Gly Arg Met Met Asp Val Glu Lys Cys Cys Thr Arg 
                245                 250                 255     


Asp Arg Asn Ser Lys Lys Arg Asn Asp Ile Gln Phe Glu Glu Thr 
            260                 265                 270     


<210>  9
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized canine

<400>  9
tttaccatca ccgtgtccaa ggacctgtac gtggtcgagt acggcggcaa tgtgaccatg       60

gagtgcaagt tccccgtgga gaagcagctg aacctgttcg ccctcatcgt gtactgggag      120

atggaggaca agaagatcat ccagttcgtg aacggcaagg aggacctgaa ggtgcagcac      180

tccagctact cccagagagc ccagctgctg aaggaccagc tgttcctggg caaggccgcc      240

ctgcagatca ccgacgtgag actgcaggac gccggcgtgt attgctgcct gatcggctac      300

ggaggcgccg actacaagag gatcaccctg aaggtgcatg caccctacag gaacatcagc      360

cagaggatca gcgtcgatcc cgtgaccagc gagcacgagc tgatgtgcca agccgagggc      420

tatcccgagg ccgaagtgat ctggaccagc agcgaccaca gggtcctgag cggcaagacc      480

accatcacca acagcaacag ggaggagaag ctgttcaacg tgaccagcac cctcaacatc      540

aacgccaccg ccaacgagat cttctactgc accttccaga ggagcggccc cgaagagaac      600

aacaccgccg agctggtgat ccccgagaga ctgcctgtgc ctgccagcga gaggacccac      660


<210>  10
<211>  220
<212>  PRT
<213>  Canis familiaris

<400>  10

Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asn Leu 
            20                  25                  30          


Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His 
    210                 215                 220 


<210>  11
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized canine and human

<400>  11
tttaccatca ccgtgtccaa ggacctgtac gtggtcgagt acggcggcaa tgtgaccatg       60

gagtgcaagt tccccgtgga gaagcagctg aacctgttcg ccctcatcgt gtactgggag      120

atggaggaca agaagatcat ccagttcgtg aacggcaagg aggacctgaa ggtgcagcac      180

tccagctact cccagagagc ccagctgctg aaggaccagc tgttcctggg caaggccgcc      240

ctgcagatca ccgacgtgag actgcaggac gccggcgtgt attgctgcct gatcggctac      300

ggaggcgccg actacaagag gatcaccctg aaggtgcatg caccctacag gaacatcagc      360

cagaggatca gcgtcgatcc cgtgaccagc gagcacgagc tgatgtgcca agccgagggc      420

tatcccgagg ccgaagtgat ctggaccagc agcgaccaca gggtcctgag cggcaagacc      480

accatcacca acagcaacag ggaggagaag ctgttcaacg tgaccagcac cctcaacatc      540

aacgccaccg ccaacgagat cttctactgc accttccaga ggagcggccc cgaagagaac      600

aacaccgccg agctggtgat ccccgagaga ctgcctgtgc ctgccagcga gaggacccac      660

ggtaccgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaatga                                      1350


<210>  12
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  12

Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asn Leu 
            20                  25                  30          


Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp Pro Val 
        115                 120                 125             


Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly Lys Thr 
145                 150                 155                 160 


Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val Thr Ser 
                165                 170                 175     


Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys Thr Phe 
            180                 185                 190         


Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val Ile Pro 
        195                 200                 205             


Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His Gly Thr Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  13
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  13

Lys Ser Ser Gln Ser Leu Leu Asn Ser Val Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  14
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  14

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  15
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  15

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  16

Phe Ala Ser Thr Arg Val Ser 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  17

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Ala Ser His Leu His Thr 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  19

Phe Ala Ser Ala Arg Val Ser 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  20

Phe Ala Ser Thr Arg Ile Ser 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  21

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Gln Tyr Phe Ser Thr Pro Leu Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  23

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Gln Gly Gln Ser Trp Pro Leu Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  25

Gln Gln Tyr Phe Ser Thr Pro Leu Thr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  26

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Tyr Thr Phe Thr Thr Tyr Gly Met Ser 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  28

Gly Tyr Thr Phe Thr Arg Tyr Asn Met His 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  29

Gly Phe Asn Ile Lys Asn Thr Tyr Met His 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  30

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  31
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  31

Trp Ile Asn Ile Tyr Ser Gly Ile Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  32

Thr Ile Tyr Pro Gly Tyr Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  33

Arg Ile Ala Pro Ala Asn Val Asp Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  34

Trp Ile Asn Ile Tyr Ser Gly Met Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  35

Arg Ile Asp Pro Ala Asn Val Asn Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  36

Phe Asp Gly Pro Asp Tyr 
1               5       


<210>  37
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  37

Glu Phe Ala Asp Asp Tyr Pro Ile Pro Pro Phe Asp Tyr 
1               5                   10              


<210>  38
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  38

Ile Tyr Tyr Asp Tyr Asp Gly Asp Ile Asp Val 
1               5                   10      


<210>  39
<211>  336
<212>  PRT
<213>  Canis familiaris

<400>  39

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  40
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine

<400>  40

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro 
            100                 105                 110         


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Ala Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
145                 150                 155                 160 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
                165                 170                 175     


Gln Phe Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
            180                 185                 190         


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
        195                 200                 205             


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
    210                 215                 220                 


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
225                 230                 235                 240 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
    290                 295                 300                 


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  41
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine

<400>  41

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro 
            100                 105                 110         


Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
        115                 120                 125             


Pro Lys Ala Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
145                 150                 155                 160 


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
                165                 170                 175     


Gln Phe Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
            180                 185                 190         


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
        195                 200                 205             


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
    210                 215                 220                 


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
225                 230                 235                 240 


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
    290                 295                 300                 


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  42
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine

<400>  42

Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys 
1               5                   10                  15      


Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu 
65                  70                  75                  80  


Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp 
                85                  90                  95      


Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp 
            100                 105                 110         


Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Lys Pro Lys Ala Thr Leu Leu Ile Ala Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val 
145                 150                 155                 160 


Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr 
                165                 170                 175     


Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys 
        195                 200                 205             


Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser 
    210                 215                 220                 


Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile 
                245                 250                 255     


Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly 
            260                 265                 270         


Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp 
        275                 280                 285             


Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser 
    290                 295                 300                 


Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala 
305                 310                 315                 320 


Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335     


<210>  43
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  43
cagatccagt tggtacagtc tggacctgaa ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttaaagtg gatgggctgg attaatatct actctggaat cccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatcg acaacctcaa aaatgaggac acggctacat atttctgtgc aagatttgat      300

ggtcccgact actggggcca aggcaccact ctcaccgtct cccca                      345


<210>  44
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  44

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ile Tyr Ser Gly Ile Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Asp Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Pro 
        115 


<210>  45
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  45
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact       60

atgagctgca agtccagtca gagcctttta aatagtgtca atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg acagtctcct aaagttctgg tatactttgc atccactagg      180

gtatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcaccagtg tgcaggctga agacctgaca acttacctct gtcagcaata ttttagcact      300

cctctcacgt tcggtgctgg gaccaagctg gaaataaaa                             339


<210>  46
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  46

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Val Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Val Leu Val Tyr Phe Ala Ser Thr Arg Val Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Thr Thr Tyr Leu Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  47
<211>  423
<212>  DNA
<213>  Mus musculus

<400>  47
atgggattca gcaggatctt tctcttcctc ctgtcagtaa ctacaggtgt ccactcccag       60

gcttatctac agcagtctgg ggctgagctg gtgaggcctg gggcctcagt gaagatctcc      120

tgcaaggctt ctggctacac atttaccaga tacaatatgc actgggtaaa gcagacacct      180

agacagggcc tggaatggat tggaactatt tatcccggat atggtgatac ttcttacaat      240

cagaaattca agggcaaggc cacactgact gtagacatat cctccagcac agcctacatg      300

cagctcacca gcctgacatc tgaggactct gcggtctatt tctgttcaag ggagtttgcc      360

gatgattacc ccattccccc ctttgactac tggggccaag gcaccactct cacagtctcc      420

tca                                                                    423


<210>  48
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  48

Met Gly Phe Ser Arg Ile Phe Leu Phe Leu Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Arg Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Thr Ile Tyr Pro Gly Tyr Gly Asp Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Ile Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ser Arg Glu Phe Ala Asp Asp Tyr Pro Ile Pro Pro Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  49
<211>  393
<212>  DNA
<213>  Mus musculus

<400>  49
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgtagat ctagtcagaa cattgtacat agtaatggaa acacctactt agaatggtac      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggaatttat tactgctttc aaggttcaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaa                                   393


<210>  50
<211>  131
<212>  PRT
<213>  Mus musculus

<400>  50

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  51
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  51
atgaaattca gctgggtcat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgt ggcagagctt gtgaggccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaaaac acctatatgc actggataaa acagaggcct      180

gaacagggcc tggagtggat tggaaggatt gctcctgcga atgttgatac taaatatgcc      240

ccgaagttcc agggcaaggc cactataact gcagacacat cctccaacac agcctacatg      300

cagctcagca ccctgacatc ggaggacact gccatctatt actgtgtcct gatctactat      360

gattacgacg gggacatcga tgtctggggc acagggacca cggtcaccgt ctcctca         417


<210>  52
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  52

Met Lys Phe Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asn Thr Tyr Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Ala Pro Ala Asn Val Asp Thr Lys Tyr Ala 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Thr Leu Thr Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Val Leu Ile Tyr Tyr Asp Tyr Asp Gly Asp Ile Asp Val 
        115                 120                 125             


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 


<210>  53
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  53
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60

gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc      120

atcacttgcc atgccagtca gaacattaat gtttggttaa gttggtacca gcagagacca      180

ggaaatattc ctaaactatt gatctataag gcttctcact tacacacagg cgtcccatca      240

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      300

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt ggccgctcac gttcggtgct      360

gggaccaaac tggagctgaa a                                                381


<210>  54
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  54

Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Asn Val Trp Leu Ser Trp Tyr Gln Gln Arg Pro Gly Asn Ile Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser His Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln 
            100                 105                 110         


Ser Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  55
<211>  402
<212>  DNA
<213>  Mus musculus

<400>  55
atgggttggc tgtggaactt gctattcctg atggcagctg cccaaagtgc ccaaacacag       60

atccagttgg tacagtctgg acctgaactg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaacc tatggaatga gctgggtgaa acaggctcca      180

ggaaagggtt taaagtggat gggctggatt aatatctact ctggaatccc aacatatgct      240

gatgacttca agggacgatt tgccttctct ttggaaacct ctgccagcac tgcctatttg      300

cagatcgaca acctcaaaaa tgaggacacg gctacatatt tctgtgcaag atttgatggt      360

cccgactact ggggccaagg caccactctc acagtctcct ca                         402


<210>  56
<211>  134
<212>  PRT
<213>  Mus musculus

<400>  56

Met Gly Trp Leu Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Thr Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Ile Tyr Ser Gly Ile Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asp Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Phe Asp Gly Pro Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser 
    130                 


<210>  57
<211>  399
<212>  DNA
<213>  Mus musculus

<400>  57
atggaatcac agacccaggt cctcatgttt cttctgctct gggtatctgg tgcctgtgca       60

gacattgtga tgacacagtc tccatcctcc ctggctgtgt cagtaggacg gaaggtcact      120

atgagctgca agtccagtca gagcctttta aatagtgtca atcaaaagaa ctatttggcc      180

tggtaccagc agaaaccagg acagtctcct aaagttctgg tatactttgc atccgctagg      240

gtatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttgcc      300

atcagcagtg tgcaggctga agacctgaca acttacttct gtcagcaata ttttagcact      360

cctctcacgt tcggtgctgg gaccaagctg gaactgaaa                             399


<210>  58
<211>  133
<212>  PRT
<213>  Mus musculus

<400>  58

Met Glu Ser Gln Thr Gln Val Leu Met Phe Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Ala Cys Ala Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Arg Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Val Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Val Leu Val Tyr Phe Ala Ser Ala Arg 
65                  70                  75                  80  


Val Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Ala Ile Ser Ser Val Gln Ala Glu Asp Leu Thr Thr Tyr 
            100                 105                 110         


Phe Cys Gln Gln Tyr Phe Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys 
    130             


<210>  59
<211>  402
<212>  DNA
<213>  Mus musculus

<400>  59
atgggttggc tgtggaactt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tacagtctgg acctgaactg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaacc tatggaatga gctgggtgaa acaggcgcca      180

ggaaagggtt taaagtggat gggctggata aatatctact ctggaatgcc aacatatgct      240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgtcagcac tgcctatttg      300

cagatcaaca acctcaaaaa tgaggacacg gctacatatt tctgtgcaag atttgatggt      360

cccgactact ggggccaagg caccactctc acagtctcct ca                         402


<210>  60
<211>  134
<212>  PRT
<213>  Mus musculus

<400>  60

Met Gly Trp Leu Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Tyr Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Ile Tyr Ser Gly Met Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Val Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Phe Asp Gly Pro Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser 
    130                 


<210>  61
<211>  399
<212>  DNA
<213>  Mus musculus

<400>  61
atggaatcac agacccaggt cctcatgttt cttctgctct gggtatctgg tgcctgtgca       60

gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact      120

atgagctgca agtccagtca gagcctttta aatagtgtca atcaaaagaa ctatttggcc      180

tggtaccagc agaaaccagg acagtctcct aaagttctgg tatactttgc atccactagg      240

atatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      300

atcagcagtg tgcaggctga agacctggca gattacttct gtcagcaata ttttagcact      360

cctctcacgt tcggtgctgg gaccaagctg gagctgaaa                             399


<210>  62
<211>  133
<212>  PRT
<213>  Mus musculus

<400>  62

Met Glu Ser Gln Thr Gln Val Leu Met Phe Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Ala Cys Ala Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Met Ser Val Gly Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Val Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Val Leu Val Tyr Phe Ala Ser Thr Arg 
65                  70                  75                  80  


Ile Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr 
            100                 105                 110         


Phe Cys Gln Gln Tyr Phe Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys 
    130             


<210>  63
<211>  417
<212>  DNA
<213>  Mus musculus

<400>  63
atgaaattca gctgggtcat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgt ggcagagctt gtgaggccag gggcctcagt caagttgtcc      120

tgcacagttt ctggcttcaa cattaaaaac acctatatgc actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaagaatt gatcctgcga atgttaatac taaatatgcc      240

ccgaagttcc agggcaaggc cactataact acagacacat cctccaacac agcctacatg      300

cagctcagca gcctgacatc ggaggacact gccatctatt actgtgtcct gattttctat      360

gattacgacg gggacatcga tgtctggggc acagggacca aggtcaccgt ctcctca         417


<210>  64
<211>  139
<212>  PRT
<213>  Mus musculus

<400>  64

Met Lys Phe Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asn Thr Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Val Asn Thr Lys Tyr Ala 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Val Leu Ile Phe Tyr Asp Tyr Asp Gly Asp Ile Asp Val 
        115                 120                 125             


Trp Gly Thr Gly Thr Lys Val Thr Val Ser Ser 
    130                 135                 


<210>  65
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  65
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60

gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc      120

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      180

ggaaatattc ctaaactatt gatctataag gcttccaact tacacacagg cgtcccatca      240

aggtttagtg gcagtggatc tggaacagat ttcacattaa ccatcagcag cctgcagcct      300

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atccgctcac gttcggtgct      360

gggaccaagc tggagctgaa a                                                381


<210>  66
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  66

Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Asn Val Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  67
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  67
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccata       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtttaaagtg gatgggctgg attaatatct actctggaat cccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatcg acaacctcaa aaatgaggac acggctacat atttctgtgc aagatttgat      300

ggtcccgact actggggcca aggcatcact ctcactgtct ccgca                      345


<210>  68
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  68

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ile Tyr Ser Gly Ile Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Asp Gly Pro Asp Tyr Trp Gly Gln Gly Ile Thr Leu Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  69
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  69
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact       60

atgagctgca agtccagtca gagcctttta aatagtgtca atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg acagtctcct aaagttctgg tatactttgc atccactagg      180

gtatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcaccagtg tgcaggctga agacctgaca acttacttct gtcagcaata ttttagcact      300

cctctcacgt tcggtgctgg gaccaagctg gaactgaaa                             339


<210>  70
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Val Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Val Leu Val Tyr Phe Ala Ser Thr Arg Val Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Thr Thr Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  71
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  71

Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Leu Thr Phe Ser Pro 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  72

Arg Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala Gln Leu Thr Val 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  73

Leu Thr Phe Ser Pro Ala Gln Leu Thr Val Gln Glu Gly Glu Asn 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  74

Ala Gln Leu Thr Val Gln Glu Gly Glu Asn Ala Thr Phe Thr Cys 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  75

Gln Glu Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu Ala Asp Ile 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  76

Ala Thr Phe Thr Cys Ser Leu Ala Asp Ile Pro Asp Ser Phe Val 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  77

Ser Leu Ala Asp Ile Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  78

Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Arg Asn 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  79

Leu Asn Trp Tyr Arg Leu Ser Pro Arg Asn Gln Thr Asp Lys Leu 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  80

Leu Ser Pro Arg Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  81

Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu Pro 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  82

Ala Ala Phe Gln Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa can be Met or Thr

<400>  83

Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg Phe Arg Val Xaa Arg 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be Met or Thr

<400>  84

Gly Arg Asp Arg Arg Phe Arg Val Xaa Arg Leu Pro Asn Gly Arg 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Met or Thr

<400>  85

Phe Arg Val Xaa Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  86

Leu Pro Asn Gly Arg Asp Phe His Met Ser Ile Val Ala Ala Arg 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  87

Asp Phe His Met Ser Ile Val Ala Ala Arg Leu Asn Asp Ser Gly 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  88

Ile Val Ala Ala Arg Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  89

Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Tyr Leu Pro 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  90

Ile Tyr Leu Cys Gly Ala Ile Tyr Leu Pro Pro Asn Thr Gln Ile 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  91

Ala Ile Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu Ser Pro Arg 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  92

Pro Asn Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu Ser Val 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  93

Asn Glu Ser Pro Arg Ala Glu Leu Ser Val Thr Glu Arg Thr Leu 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  94

Ala Glu Leu Ser Val Thr Glu Arg Thr Leu Glu Pro Pro Thr Gln 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  95

Thr Glu Arg Thr Leu Glu Pro Pro Thr Gln Ser Pro Ser Pro Pro 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  96

Glu Pro Pro Thr Gln Ser Pro Ser Pro Pro Pro Arg Leu Ser Gly 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  97

Ser Pro Ser Pro Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly Leu 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Canis familiaris

<400>  98

Pro Ser Pro Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly Leu Val 
1               5                   10                  15  


<210>  99
<211>  25
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Met or Thr

<400>  99

Arg Phe Arg Val Xaa Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser 
1               5                   10                  15      


Ile Val Ala Ala Arg Leu Asn Asp Ser 
            20                  25  


<210>  100
<211>  26
<212>  PRT
<213>  Canis familiaris


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  100

Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg 
1               5                   10                  15      


Phe Arg Val Xaa Arg Leu Pro Asn Gly Arg 
            20                  25      


<210>  101
<211>  31
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa can be Met or Thr

<400>  101

Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg Phe Arg Val Xaa Arg 
1               5                   10                  15      


Leu Pro Asn Gly Arg Asp Phe His Met Ser Ile Val Ala Ala Arg 
            20                  25                  30      


<210>  102
<211>  31
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa can be Met or Thr

<400>  102

Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu Pro 
1               5                   10                  15      


Gly Arg Asp Arg Arg Phe Arg Val Xaa Arg Leu Pro Asn Gly Arg 
            20                  25                  30      


<210>  103
<211>  45
<212>  PRT
<213>  Canis familiaris


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa can be Met or Thr

<400>  103

Asn Gln Thr Asp Lys Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu Pro 
1               5                   10                  15      


Gly Arg Asp Arg Arg Phe Arg Val Xaa Arg Leu Pro Asn Gly Arg Asp 
            20                  25                  30          


Phe His Met Ser Ile Val Ala Ala Arg Leu Asn Asp Ser 
        35                  40                  45  


<210>  104
<211>  20
<212>  PRT
<213>  Canis familiaris


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be Met or Thr

<400>  104

Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg Phe Arg Val Xaa Arg Leu 
1               5                   10                  15      


Pro Asn Gly Arg 
            20  


<210>  105
<211>  867
<212>  DNA
<213>  Canis familiaris

<400>  105
atggggagcc ggcgggggcc ctggccgctc gtctgggccg tgctgcagct gggctggtgg       60

ccaggatggc tcctagactc ccctgacagg ccctggagcc cgctcacctt ctccccggcg      120

cagctcacgg tgcaggaggg agagaacgcc acgttcacct gcagcctggc cgacatcccc      180

gacagcttcg tgctcaactg gtaccgcctg agcccccgca accagacgga caagctggcc      240

gccttccagg aggaccgcat cgagccgggc cgggacaggc gcttccgcgt catgcggctg      300

cccaacgggc gggacttcca catgagcatc gtcgctgcgc gcctcaacga cagcggcatc      360

tacctgtgcg gggccatcta cctgcccccc aacacacaga tcaacgagag tccccgcgca      420

gagctctccg tgacggagag aaccctggag ccccccacac agagccccag ccccccaccc      480

agactcagcg gccagttgca ggggctggtc atcggcgtca cgagcgtgct ggtgggtgtc      540

ctgctactgc tgctgctgac ctgggtcctg gccgctgtct tccccagggc cacccgaggt      600

gcctgtgtgt gcgggagcga ggacgagcct ctgaaggagg gccccgatgc agcgcccgtc      660

ttcaccctgg actacgggga gctggacttc cagtggcgag agaagacgcc ggagcccccg      720

gcgccctgtg ccccggagca gaccgagtat gccaccatcg tcttcccggg caggccggcg      780

tccccgggcc gcagggcctc ggccagcagc ctgcagggag cccagcctcc gagccccgag      840

gacggacccg gcctgtggcc cctctga                                          867


<210>  106
<211>  288
<212>  PRT
<213>  Canis familiaris

<400>  106

Met Gly Ser Arg Arg Gly Pro Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Trp Pro Gly Trp Leu Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Gln Leu Thr Val Gln Glu Gly Glu 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ala Asp Ile Pro Asp Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Leu Ser Pro Arg Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Gln Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Met Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Ile Val Ala 
            100                 105                 110         


Ala Arg Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Asn Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu Ser Val 
    130                 135                 140                 


Thr Glu Arg Thr Leu Glu Pro Pro Thr Gln Ser Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Arg Leu Ser Gly Gln Leu Gln Gly Leu Val Ile Gly Val Thr Ser Val 
                165                 170                 175     


Leu Val Gly Val Leu Leu Leu Leu Leu Leu Thr Trp Val Leu Ala Ala 
            180                 185                 190         


Val Phe Pro Arg Ala Thr Arg Gly Ala Cys Val Cys Gly Ser Glu Asp 
        195                 200                 205             


Glu Pro Leu Lys Glu Gly Pro Asp Ala Ala Pro Val Phe Thr Leu Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro 
225                 230                 235                 240 


Ala Pro Cys Ala Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Gly Arg Pro Ala Ser Pro Gly Arg Arg Ala Ser Ala Ser Ser Leu Gln 
            260                 265                 270         


Gly Ala Gln Pro Pro Ser Pro Glu Asp Gly Pro Gly Leu Trp Pro Leu 
        275                 280                 285             


<210>  107
<211>  870
<212>  DNA
<213>  Canis familiaris

<400>  107
atgagaatgt ttagtgtctt tacattcatg gcctactgcc atttgctaaa agcatttacg       60

atcacagttt ctaaggacct gtatgtggta gagtatggtg gcaatgtgac aatggaatgc      120

aaattcccgg tggaaaaaca gttaaacttg tttgcactaa tcgtctactg ggaaatggag      180

gataaaaaaa ttatacaatt tgtgaatgga aaggaagacc tgaaagttca gcacagcagc      240

tacagccaga gggctcagct attgaaggac cagctcttct tggggaaggc tgcgcttcag      300

atcacagatg tgagattgca ggatgcaggg gtttactgct gcttgatcgg ctatggcggt      360

gctgactaca agcggattac tttgaaagtt catgccccgt accgcaacat cagccaaaga      420

atttctgtgg atcctgtcac ctctgaacat gaactaatgt gtcaggctga gggttaccct      480

gaggctgaag tcatctggac aagcagtgac caccgagtcc tgagtggcaa aaccaccatc      540

actaattcca atagggaaga gaagcttttc aatgtgacca gcacgctgaa catcaatgca      600

acagctaatg agattttcta ctgcactttt caaagatcag gtcctgagga aaacaatact      660

gccgagttgg tcatcccaga acgactgccc gttccagcaa gtgagaggac tcatttcatg      720

attctgggac ctttcctgtt gcttcttggt gtagtcctgg cagtcacttt ctgtctaaaa      780

aaacatggga gaatgatgga tgtggaaaaa tgttgcaccc gagataggaa ctcaaagaaa      840

cgaaatgata tacaatttga agagacataa                                       870


<210>  108
<211>  289
<212>  PRT
<213>  Canis familiaris

<400>  108

Met Arg Met Phe Ser Val Phe Thr Phe Met Ala Tyr Cys His Leu Leu 
1               5                   10                  15      


Lys Ala Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Gly Asn Val Thr Met Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asn Leu Phe Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Lys Ile 
    50                  55                  60                  


Ile Gln Phe Val Asn Gly Lys Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Ser Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Phe Leu Gly Lys 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Arg Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val His Ala Pro Tyr Arg Asn Ile Ser Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Val Thr Ser Glu His Glu Leu Met Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Ser Ser Asp His Arg Val Leu Ser Gly 
                165                 170                 175     


Lys Thr Thr Ile Thr Asn Ser Asn Arg Glu Glu Lys Leu Phe Asn Val 
            180                 185                 190         


Thr Ser Thr Leu Asn Ile Asn Ala Thr Ala Asn Glu Ile Phe Tyr Cys 
        195                 200                 205             


Thr Phe Gln Arg Ser Gly Pro Glu Glu Asn Asn Thr Ala Glu Leu Val 
    210                 215                 220                 


Ile Pro Glu Arg Leu Pro Val Pro Ala Ser Glu Arg Thr His Phe Met 
225                 230                 235                 240 


Ile Leu Gly Pro Phe Leu Leu Leu Leu Gly Val Val Leu Ala Val Thr 
                245                 250                 255     


Phe Cys Leu Lys Lys His Gly Arg Met Met Asp Val Glu Lys Cys Cys 
            260                 265                 270         


Thr Arg Asp Arg Asn Ser Lys Lys Arg Asn Asp Ile Gln Phe Glu Glu 
        275                 280                 285             


Thr 
    


<210>  109
<211>  423
<212>  DNA
<213>  Mus musculus

<400>  109
atgggattca gcaggatctt tctcttcctc ctgtcagtaa ctacaggtgt ccactcccag       60

gcttatctac agcagtctgg ggctgagctg gtgaggcctg gggcctcagt gaagatgtcc      120

tgcaaggctt ttggctacac atttaccagt tacaatatgc actgggtgaa gcagacacct      180

agacagggcc tggaatggat tggaaccatt tatccaggag atggtgacgc ttcctacaat      240

cagaaattcc aggacaaggc cacactgact gttgacaaat cctccagcac agcctacatg      300

cagctcagca gcctgacatc tgaagactct gcggtctatt tctgttcaag ggagtttgcc      360

gatgcttacc ccattccccc ctttgactac tggggccaag gcaccactct cacagtctcc      420

tca                                                                    423


<210>  110
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  110

Met Gly Phe Ser Arg Ile Phe Leu Phe Leu Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Phe Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Thr Ile Tyr Pro Gly Asp Gly Asp Ala Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ser Arg Glu Phe Ala Asp Ala Tyr Pro Ile Pro Pro Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140     


<210>  111
<211>  393
<212>  DNA
<213>  Mus musculus

<400>  111
atgaagttgc ctgttaggct gttggtgctg attttctgga ttcctgcttc cagtagtgat       60

gttttgatga cccaaactcc actctccctg gttgtcagtc ttggagatca ggcctccatc      120

tcttgcagat ctagtcagag cattgtatat agtaatggaa acacctattt agaatggtac      180

ctgcaaaaac caggccagtc tccaaagctc ctgatttaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaa                                   393


<210>  112
<211>  131
<212>  PRT
<213>  Mus musculus

<400>  112

Met Lys Leu Pro Val Arg Leu Leu Val Leu Ile Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Val Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val Tyr Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  113
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  113

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Leu Asp Ser Pro Asp Arg 
            20                  25                  30          


Pro Trp Ser Pro Leu Thr Phe Ser Pro Ala Gln Leu Thr Val Gln Glu 
        35                  40                  45              


Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu Ala Asp Ile Pro Asp Ser 
    50                  55                  60                  


Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Arg Asn Gln Thr Asp Lys 
65                  70                  75                  80  


Leu Ala Ala Phe Gln Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg 
                85                  90                  95      


Phe Arg Val Met Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Ile 
            100                 105                 110         


Val Ala Ala Arg Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile 
        115                 120                 125             


Tyr Leu Pro Pro Asn Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu 
    130                 135                 140                 


Ser Val Thr Glu Arg Thr Leu Glu Pro Pro Thr Gln Ser Pro Ser Pro 
145                 150                 155                 160 


Pro Pro Arg Leu Ser Gly Gln Leu Gln Gly Leu Val Gly Thr Asp Lys 
                165                 170                 175     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            180                 185                 190         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    210                 215                 220                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Lys 
    


<210>  114
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  114

Ile Phe Tyr Asp Tyr Asp Gly Asp Ile Asp Val 
1               5                   10      


