                         SEQUENCE LISTING

<110>  Neurimmune Holding AG
 
<120>  Antibody-based therapy of transthyretin (TTR) amyloidosis and 
       human-derived antibodies therefor

<130>  NE30A43/P-WO

<150>  EP 13199251.3
<151>  2013-12-20

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  NI-301.59F1 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  1
gag gtg cag ctg gtg gag tct ggg gga ggg ttg gtc cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gcc tct gga ttc act ttt agt aat tat         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr           
            20                  25                  30                    

tgg atg agt tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtg        144
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcc aat ata aat caa gat agt gag aaa tac tat gtg gac tct gtg aag        192
Ala Asn Ile Asn Gln Asp Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys           
    50                  55                  60                            

ggc cga ttc gcc atc tcc aga gac aac tcc aag aac tca ctg tat ctg        240
Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr Leu           
65                  70                  75                  80            

caa atg aac agc ctg aga gtc gag gac acg ggc gtg tat tac tgt gcg        288
Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga gat cgc tat tgc agt ggt ggg aga tgc tcc cgg ggt aac aac tgg        336
Arg Asp Arg Tyr Cys Ser Gly Gly Arg Cys Ser Arg Gly Asn Asn Trp           
            100                 105                 110                   

ttc gac ccc tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                378
Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  2
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Tyr Cys Ser Gly Gly Arg Cys Ser Arg Gly Asn Asn Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  3
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-301.59F1 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  3
gaa att gtg ttg acg cag tct cca gcc act ctg tct ctg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gag aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt aga agc aac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn           
            20                  25                  30                    

tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat ggt gca tcc acc agg gcc act gat atc cca gcc agg ttc agt ggc        192
Tyr Gly Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gaa ttc act ctc acc atc agc agc ctg cag tct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser           
65                  70                  75                  80            

gag gat ttt gca gtt tat tac tgt cag caa tat aat aac tgg cct ccg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro           
                85                  90                  95                

tac act ttt ggc cag ggg acc aaa gtg gat atc aaa                        324
Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys                           
            100                 105                                       


<210>  4
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  5
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-301.35G11 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  5
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gtg cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gcc tct gga ttc act ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gtt cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca tct att agt ggt agt ggt gat aca aca aaa tac aca gac tcc gtg        192
Ser Ser Ile Ser Gly Ser Gly Asp Thr Thr Lys Tyr Thr Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg gtg ttt        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe           
65                  70                  75                  80            

ctg caa atg agc agc ctg aga gcc gag gac acg gcc cta tat tac tgt        288
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

gtg aaa gat ggt agt gga cgg atc gat cct ttt gct tta tgg ggc caa        336
Val Lys Asp Gly Ser Gly Arg Ile Asp Pro Phe Ala Leu Trp Gly Gln           
            100                 105                 110                   

ggg aca atg gtc acc gtc tct tcg                                        360
Gly Thr Met Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  6
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Asp Thr Thr Lys Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Ser Gly Arg Ile Asp Pro Phe Ala Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-301.35G11 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(117)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (163)..(183)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (280)..(306)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  7
gaa att gtg atg aca cag tct cca ctc tcc ctg ccc gtc acc ctt gga         48
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly           
1               5                   10                  15                

cag ccg gcc tcc atc tcc tgc agg tct agt cgt agt ctc gta tac agt         96
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Val Tyr Ser           
            20                  25                  30                    

gat gga aac att tac ttg aat tgg ttt cag cag agg cca ggc caa tct        144
Asp Gly Asn Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser           
        35                  40                  45                        

cca agg cgc cta att tat aag gtt tct aac cgg gac tct ggg gtc cca        192
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro           
    50                  55                  60                            

gac aga ttc agt ggc agt ggg tca gac act gac ttc aca ctg aga atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Arg Ile           
65                  70                  75                  80            

agc agg gtg gag gct gag gat gtt ggg gtc tat tac tgc atg cag ggt        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

aca cac tgg cct agg acg ttc ggc caa ggg acc aag gtg gag atc aaa        336
Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  8
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-301.37F1 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  9
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc agt gtc tct ggt ggc tcc atc atc agt agg         96
Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ile Ser Arg           
            20                  25                  30                    

agt tcc tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag        144
Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg ggt atc tat cat agt ggg aac act tac gac aac ccg tcc        192
Trp Ile Gly Gly Ile Tyr His Ser Gly Asn Thr Tyr Asp Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga ctc acc atg tcc gta gac acg tcg aag aac cag ttc        240
Leu Lys Ser Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aat ctg agg tct gtg acc gcc gca gac acg gct gtg tat tac        288
Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg agg ata gtg ccg ggg ggt gat gct ttt gat atc tgg ggc caa        336
Cys Ala Arg Ile Val Pro Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln           
            100                 105                 110                   

ggg aca atg gtc acc gtc tct tcg                                        360
Gly Thr Met Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  10
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ile Ser Arg 
            20                  25                  30          


Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Gly Ile Tyr His Ser Gly Asn Thr Tyr Asp Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Val Pro Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-301.37F1 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  11
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc aca atc gct tgc cgg gcc agt cag agc gtt ggc acc tat         96
Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa aga ggg aaa gcc cct aaa ctc ctc atc        144
Leu Asn Trp Tyr Gln Gln Lys Arg Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

ttt gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gac ttt gca act tac tac tgt caa cag agt tac agt tct cct cca        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro           
                85                  90                  95                

acg ttc ggc caa ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  12
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln Ser Val Gly Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Arg Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-301.2F5 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  13
gag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cgg tct agg agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Ser Arg Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca acc tct gga ttc acc ttc agt aac tat         96
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asn Tyr           
            20                  25                  30                    

gcg atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcc att att tca tat gat gga aac aat aaa tac tac gca gac tcc gtg        192
Ala Ile Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

agg ggc cga ttc acc gtc tcc aga gac aat tcc aag aac aca ttc tat        240
Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Phe Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga att gag gac acg gct gta tat ttt tgt        288
Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aga ggg agc ggt aga gca gct cgt cac tgg ttc gac ccc tgg ggc        336
Ala Arg Gly Ser Gly Arg Ala Ala Arg His Trp Phe Asp Pro Trp Gly           
            100                 105                 110                   

cag ggc acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  14
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Ser Arg Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Arg Ala Ala Arg His Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-301.2F5 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(306)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  15
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc act gga acc agc agt gac gtt ggt ggt tat         96
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr           
            20                  25                  30                    

aac tat gtc tcc tgg tac caa caa tac cca ggc aaa gcc ccc aaa gtc        144
Asn Tyr Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Val           
        35                  40                  45                        

atg att ttt gat gtt ttt aat cgg cct tca ggg gtt tct aat cgc ttc        192
Met Ile Phe Asp Val Phe Asn Arg Pro Ser Gly Val Ser Asn Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg acc atc tct gga ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gca gag gac gag gct gat tat tac tgc agt tca tat aca agc agc        288
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser           
                85                  90                  95                

gtc act cct cac tgg gtg ttc ggc gga ggg acc aag ctg acc gtc cta        336
Val Thr Pro His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu           
            100                 105                 110                   


<210>  16
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Met Ile Phe Asp Val Phe Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Val Thr Pro His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  17
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  NI-301.28B3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(348)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  17
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tcc ggt ggc tcc atc act agt agt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Ser           
            20                  25                  30                    

aat ttc tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag        144
Asn Phe Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg gct att tat tct agt gga aac acc tac tac aac ccg tcc        192
Trp Ile Gly Ala Ile Tyr Ser Ser Gly Asn Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtc acc ata tcc gta gac acg tcc aag aaa aag ttc        240
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Lys Phe           
65                  70                  75                  80            

tcc ctg aag ctg agc tct gtg acc gcc gct gac acg gct gtc tat tac        288
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga cac tct tgt agt agt gcc agc tgc tat cct ccc ggt ttc        336
Cys Ala Arg His Ser Cys Ser Ser Ala Ser Cys Tyr Pro Pro Gly Phe           
            100                 105                 110                   

tgg ttc gac ccc tgg ggc cag gga acc ctg gtc acc gtc tcc tcg            381
Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  18
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Ser 
            20                  25                  30          


Asn Phe Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile Tyr Ser Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Lys Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Ser Cys Ser Ser Ala Ser Cys Tyr Pro Pro Gly Phe 
            100                 105                 110         


Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  19
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-301.28B3 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(294)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  19
gaa att gtg atg aca cag tct cca gcc acc ctg tct gcg tct cca ggg         48
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag act gtt agt tac aac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Tyr Asn           
            20                  25                  30                    

tta gcc tgg tac cag cag aaa cct ggc cag gct ccc cgg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat ggc gcg tcc acc agg gcc act ggt atc cca ggc agg ttc agt ggc        192
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gag ttc act ctc acc atc agc agc ctg cag tct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser           
65                  70                  75                  80            

gaa gat ttt gca gtt tat tac tgt cag caa tat aat aac tgg cct ccg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro           
                85                  90                  95                

tgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa                        324
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  20
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Tyr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  21
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)
<223>  NI-301.119C12 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(351)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  21
cag gtg cag ctg cag gag tcg ggc cca aga ctg gtg aag cct tca cag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt ggt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly           
            20                  25                  30                    

gtt tac tac tgg agc tgg atc cgc cag cac cca ggg aag ggc ctg gag        144
Val Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att gga tat att tct aat act ggg aac acc tac tac aac ccg tcc        192
Trp Ile Gly Tyr Ile Ser Asn Thr Gly Asn Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtt acc ata tcg ata gac acc tcc aag aac cag ttc        240
Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctc aac ctg cgc tct gtg act gcc gcg gac acg gcc gac tat ttc        288
Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Asp Tyr Phe           
                85                  90                  95                

tgt gcg aga gag tat tgt agt ggt ggt aat tgc tac tct cgc ttc tac        336
Cys Ala Arg Glu Tyr Cys Ser Gly Gly Asn Cys Tyr Ser Arg Phe Tyr           
            100                 105                 110                   

tac tac atg gac gtc tgg ggc aaa ggg acc acg gtc acc gtc tcc tcg        384
Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser           
        115                 120                 125                       


<210>  22
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Val Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Ser Asn Thr Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Asp Tyr Phe 
                85                  90                  95      


Cys Ala Arg Glu Tyr Cys Ser Gly Gly Asn Cys Tyr Ser Arg Phe Tyr 
            100                 105                 110         


Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  23
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NI-301.119C12 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(306)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  23
cag tct gtg ctg acg cag ccg ccc tca gtg tct ggg gcc cca ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tcc tgc act ggg agc agc tcc aac atc ggg gca ggt         96
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly           
            20                  25                  30                    

tat ggt gta cac tgg tac cag caa ctt tca gga aca ccc ccc aaa ctc        144
Tyr Gly Val His Trp Tyr Gln Gln Leu Ser Gly Thr Pro Pro Lys Leu           
        35                  40                  45                        

ctc atc tat gga gac aac aat cgg ccc tca ggg gtc cct gac cga ttc        192
Leu Ile Tyr Gly Asp Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc act ggg ctc        240
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu           
65                  70                  75                  80            

cag gct gag gat gag gct cat tat tac tgc cag tcc tat gac acc acc        288
Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Gln Ser Tyr Asp Thr Thr           
                85                  90                  95                

ttg agt ggt tcg agg gtg ttc ggc gga ggg acc aag ctg acc gtc cta        336
Leu Ser Gly Ser Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu           
            100                 105                 110                   


<210>  24
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Gly Val His Trp Tyr Gln Gln Leu Ser Gly Thr Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Gln Ser Tyr Asp Thr Thr 
                85                  90                  95      


Leu Ser Gly Ser Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  25
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-301.5D8 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  25
cag gtg cag cta cag cag tgg ggc gca gga cgg ttg aag cct tcg gag         48
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Arg Leu Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acg tgc gct gtc tat ggt ggg tct ttc agt gct tac         96
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ala Tyr           
            20                  25                  30                    

tac tgg aat tgg atc cgc cag gcc cca ggg aag ggg ctg gag tgg att        144
Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggt gaa gtc agt cat ggt ggc agc agc aac tac agc ccg tcc ctc agg        192
Gly Glu Val Ser His Gly Gly Ser Ser Asn Tyr Ser Pro Ser Leu Arg           
    50                  55                  60                            

ggt cga gtc gcc att tct tta gac acg tcc aag agc cag ttc tcc ctg        240
Gly Arg Val Ala Ile Ser Leu Asp Thr Ser Lys Ser Gln Phe Ser Leu           
65                  70                  75                  80            

agg ctg aat tct gtg acc gcc gcg gac acg gct gtt tat tac tgt gcg        288
Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga ggc agc cct gta gta cta cca ggt gcc aga ttc gac ccc tgg ggc        336
Arg Gly Ser Pro Val Val Leu Pro Gly Ala Arg Phe Asp Pro Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  26
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Arg Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Ser His Gly Gly Ser Ser Asn Tyr Ser Pro Ser Leu Arg 
    50                  55                  60                  


Gly Arg Val Ala Ile Ser Leu Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ser Pro Val Val Leu Pro Gly Ala Arg Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-301.5D8 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(297)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  27
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg ttt cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Phe Pro Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc act gga acc agc agt gat gtt ggg agt tat         96
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr           
            20                  25                  30                    

aac ctt gtc tcc tgg tac caa caa cac cca ggc aaa gcc ccc aaa ctc        144
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu           
        35                  40                  45                        

ttg att tat gag gtc aat aag cgg ccc tca gga gtt tct act cgc ttc        192
Leu Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Thr Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg acg atc tct ggg ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag act gag gac gag gct gat tat tac tgc tgc tca tat gca ggt agt        288
Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser           
                85                  90                  95                

act aag gtc ttc gga att ggg acc aag gtc acc gtc cta                    327
Thr Lys Val Phe Gly Ile Gly Thr Lys Val Thr Val Leu                       
            100                 105                                       


<210>  28
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Phe Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Thr Lys Val Phe Gly Ile Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  29
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-301.9D5 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  29
cag gtg cag ctg cag gag tcg ggc cca ggc ctg gtg aag cct tca gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc att gtc tct ggt gtc tcc atc aga agt ggt         96
Thr Leu Ser Leu Thr Cys Ile Val Ser Gly Val Ser Ile Arg Ser Gly           
            20                  25                  30                    

ggt tac tac tgg agc tgg atc cgg cag cac cca ggg aag ggc ctg gag        144
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg gtt ggg ttc atc tat tac act ggg aac acc tac tac aac ccg tcc        192
Trp Val Gly Phe Ile Tyr Tyr Thr Gly Asn Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gct acc ata tca gta gac acc tct aag aac cag ttc        240
Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg agg ctg acc gct gtg act gcc gcg gac acg gcc gtg tat tac        288
Ser Leu Arg Leu Thr Ala Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga gat tgt agt ggt ggc agc tgc ccc gag tcc tac ttt gac        336
Cys Ala Arg Asp Cys Ser Gly Gly Ser Cys Pro Glu Ser Tyr Phe Asp           
            100                 105                 110                   

tcc tgg ggt cgg ggc acc ctg gtc acc gtc tcc tcg                        372
Ser Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  30
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ile Val Ser Gly Val Ser Ile Arg Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Phe Ile Tyr Tyr Thr Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Thr Ala Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Cys Ser Gly Gly Ser Cys Pro Glu Ser Tyr Phe Asp 
            100                 105                 110         


Ser Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-301.9D5 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (268)..(297)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  31
gaa att gtg atg aca cag tct cca gcc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgt agg gcc agt cag agt gtt cgc agt ttc         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Phe           
            20                  25                  30                    

tta gcc tgg tac caa cag aaa tct ggc cag gct ccc cga ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc aag agg gcc act ggc atc cca gcc agg ttc agt gac        192
Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Asp           
    50                  55                  60                            

agt ggg tct gga aca gac ttc act ctc acc atc agc aga cta gag act        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Thr           
65                  70                  75                  80            

gaa gac tct gcg gtt tat tac tgt cag cag cgt acc aac tgg cct cca        288
Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Pro           
                85                  90                  95                

cac ctc act ttc ggc gga ggg acc aag gtg gaa atc aaa                    327
His Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                       
            100                 105                                       


<210>  32
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Asp 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Thr 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Pro 
                85                  90                  95      


His Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  33
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-301.104F5 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  33
cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct gag agg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Glu Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc agg agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca gtt ata tgg ttt gat gga agt aat aaa tac tat gca gac tcc gtg        192
Ala Val Ile Trp Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc gtc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtc tac tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga gat ggt ata gca gcc act tat gcg gac tac tgg ggc cag gga        336
Ala Arg Asp Gly Ile Ala Ala Thr Tyr Ala Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  34
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Glu Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ile Ala Ala Thr Tyr Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-301.104F5 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  35
gaa att gtg ttg aca cag tct cca gcc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt cgc agc tac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr           
            20                  25                  30                    

tta gcc tgg tac caa caa aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat ggt gca tcc aac agg gcc act ggc atc cca gcc agg ttc agt ggc        192
Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc agc ctg gag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttt gca gtt tat tac tgt cag caa cgt agc aac tgg ccg atc        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile           
                85                  90                  95                

acc ttc ggc caa ggg aca cga ctg gag att aaa                            321
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                               
            100                 105                                       


<210>  36
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-301.21F10 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(114)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (157)..(207)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (304)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  37
cag gtg cag ctg gtg gag tcg ggg gga ggt ttg gtc cag cct ggg ggg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ttg aga ctg tcc tgt gcg gtc tct gga ttc acc ctt agt agt ctt         96
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Ser Ser Leu           
            20                  25                  30                    

agt tct tat tac atg agt tgg gtc cgc cag gct cca ggg aag ggg ctg        144
Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu           
        35                  40                  45                        

gag tgg gtg gcc act ata aac cca ggt gga agt gag aag tcc tat gtg        192
Glu Trp Val Ala Thr Ile Asn Pro Gly Gly Ser Glu Lys Ser Tyr Val           
    50                  55                  60                            

gac tct gtg aag ggc cga ttc acc gtc tcc aga gac aac gcc agg agc        240
Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Ser           
65                  70                  75                  80            

tca gta tat ttg caa atg gac agc ctg aca gtc gag gac acg gct att        288
Ser Val Tyr Leu Gln Met Asp Ser Leu Thr Val Glu Asp Thr Ala Ile           
                85                  90                  95                

tat tac tgt gcg aga cca aga tat tgc act agt ggt ggt tgc tat ttt        336
Tyr Tyr Cys Ala Arg Pro Arg Tyr Cys Thr Ser Gly Gly Cys Tyr Phe           
            100                 105                 110                   

gac aac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                    375
Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  38
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Ser Ser Leu 
            20                  25                  30          


Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Thr Ile Asn Pro Gly Gly Ser Glu Lys Ser Tyr Val 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Ser 
65                  70                  75                  80  


Ser Val Tyr Leu Gln Met Asp Ser Leu Thr Val Glu Asp Thr Ala Ile 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Pro Arg Tyr Cys Thr Ser Gly Gly Cys Tyr Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  39
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-301.21F10 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(297)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  39
cag tct gcc ctg act cag cct cgc tca gtg tcc ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tca gtc acc atc tcc tgc act gca acc aat agt gat gtt ggc gat tat         96
Ser Val Thr Ile Ser Cys Thr Ala Thr Asn Ser Asp Val Gly Asp Tyr           
            20                  25                  30                    

aag tct gtc tcc tgg tac caa caa cac cca ggc aaa gcc ccc aaa ctc        144
Lys Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu           
        35                  40                  45                        

atg att tat gat gtc ggt agg cgg ccc tca ggg gtc cct gat cgc ttc        192
Met Ile Tyr Asp Val Gly Arg Arg Pro Ser Gly Val Pro Asp Arg Phe           
    50                  55                  60                            

tct ggc tcc aaa tct gac aac acg gcc ttc ctg acc atc tct ggg ctc        240
Ser Gly Ser Lys Ser Asp Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag act gag gat gaa gct gat tac ttt tgc tgt ata tat gta ggc agg        288
Gln Thr Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ile Tyr Val Gly Arg           
                85                  90                  95                

tct tcg gtg ttc ggc gga ggg acc aag ttg acc gtc ctg                    327
Ser Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                       
            100                 105                                       


<210>  40
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Ala Thr Asn Ser Asp Val Gly Asp Tyr 
            20                  25                  30          


Lys Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Gly Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ile Tyr Val Gly Arg 
                85                  90                  95      


Ser Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  41
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-301.9G12 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(108)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (151)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  41
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc gct gtc tct ggt ttc tcc atc agc agt ggt         96
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Ile Ser Ser Gly           
            20                  25                  30                    

tac tac tgg ggc tgg atc cgg cag ccc cca ggg acg ggg ctg gag tgg        144
Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Thr Gly Leu Glu Trp           
        35                  40                  45                        

att ggg agt atg tat cat agt ggg agg acc tac tac aac ccg tcc ctc        192
Ile Gly Ser Met Tyr His Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu           
    50                  55                  60                            

aag agt cga gtc acc ata tca gta gac acg tcc aag aac cag ttg tcc        240
Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu Ser           
65                  70                  75                  80            

ctg aag ctg agc tct gtg acc gcc gca gac acg gcc gtg tat tac tgt        288
Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg agg ggc ttc gat act agt ggt tcc cat cgg ccc ctc tcg act gac        336
Ala Arg Gly Phe Asp Thr Ser Gly Ser His Arg Pro Leu Ser Thr Asp           
            100                 105                 110                   

tac tgg ggc cag ggc acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  42
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Thr Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Met Tyr His Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Asp Thr Ser Gly Ser His Arg Pro Leu Ser Thr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  43
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-301.9G12 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  43
cag tct gtg ttg acg cag ccg ccc tca gtg tct gcg gcc cca gga cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln           
1               5                   10                  15                

aag gtc acc atc tcc tgc tct gga agc agc tcc aac att ggg aat aat         96
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn           
            20                  25                  30                    

tat gta tcc tgg tac cag cag ctc cca gga aca gcc ccc aaa ctc ctc        144
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

att tat gac aat aat aag cga ccc tca ggg att cct gac cga atc tct        192
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Ile Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acg tca gcc acc ctg ggc atc acc gga ctc cag        240
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln           
65                  70                  75                  80            

act ggg gac gag gcc gat tat tac tgc gga acc tgg gat agc agc ctg        288
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu           
                85                  90                  95                

agt gct tat gtc ttc gga act ggg acc aag gtc acc gtc cta                330
Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu                   
            100                 105                 110                   


<210>  44
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Ile Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  45
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  NI-301.12D3 variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  45
gag gtg cag ctg gtg gag act ggg gga ggc gtg gtc cag cct ggg agg         48
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gcg tct gga ttc acc ttc agg aac tat         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asn Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cgg gcc cca ggc agg ggg ctg gag tgg gta        144
Gly Met His Trp Val Arg Arg Ala Pro Gly Arg Gly Leu Glu Trp Val           
        35                  40                  45                        

gca gtt ata tgg tct gat gga agt gat aaa tac tat gca gac tcc gtg        192
Ala Val Ile Trp Ser Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

gag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg gtg ttt        240
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe           
65                  70                  75                  80            

ctc caa atg aac agc ctg aga gcc gac gac acg gct gta tac ttc tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aga gag ccg agc agc acc tgg gct ttt gac tac tgg ggc cag gga        336
Ala Arg Glu Pro Ser Ser Thr Trp Ala Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tcg                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  46
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Arg Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Pro Ser Ser Thr Trp Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  47
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-301.12D3 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  47
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg tct cct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln           
1               5                   10                  15                

tcg atc acc atc tcc tgc act gga acc agc agt gat gtt ggg ggt tat         96
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr           
            20                  25                  30                    

aac ctt gtc tcc tgg tac caa cag cac cca ggc aaa gcc ccc aaa ctc        144
Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu           
        35                  40                  45                        

atg att tat gag gac att aag ggg ccc tca ggg gtt tct aat cgc ttc        192
Met Ile Tyr Glu Asp Ile Lys Gly Pro Ser Gly Val Ser Asn Arg Phe           
    50                  55                  60                            

tct ggc tcc aag tct ggc aac acg gcc tcc ctg aca atc tct ggg ctc        240
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu           
65                  70                  75                  80            

cag gct gag gac gag gct gat tat ttc tgc tgc tca tat gca ggt act        288
Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ser Tyr Ala Gly Thr           
                85                  90                  95                

ggc act ctg gta ttc ggc gga ggg acc aag ctg acc gtc cta                330
Gly Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  48
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Asp Ile Lys Gly Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ser Tyr Ala Gly Thr 
                85                  90                  95      


Gly Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-301.59F1 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  Epitope of NI-301.59F1 antibody, aa 61to aa 69

<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  Epitope of NI-301.59F1 antibody, aa 61 to aa 69

<400>  49

Glu Glu Glu Phe Val Glu Gly Ile Tyr 
1               5                   


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-301.35G11 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Epitope of NI-301.35G11 antibody, aa 53 to aa 63

<400>  50

Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu 
1               5                   10      


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope recognized by NI-301.37F1 antibody


<220>
<221>  PEPTIDE
<222>  (1)..(5)
<223>  Epitope of NI-301.37F1 antibody, aa 41 to aa 45

<400>  51

Trp Glu Pro Phe Ala 
1               5   


<210>  52
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-301.37F1-PIMC variable heavy chain (VH) sequence after 
       correction of primer induced mutations

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  52
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc agt gtc tct ggt ggc tcc atc atc agt agg         96
Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ile Ser Arg           
            20                  25                  30                    

agt tcc tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag        144
Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg ggt atc tat cat agt ggg aac act tac gac aac ccg tcc        192
Trp Ile Gly Gly Ile Tyr His Ser Gly Asn Thr Tyr Asp Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga ctc acc atg tcc gta gac acg tcg aag aac cag ttc        240
Leu Lys Ser Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aat ctg agg tct gtg acc gcc gca gac acg gct gtg tat tac        288
Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg agg ata gtg ccg ggg ggt gat gct ttt gat atc tgg ggc caa        336
Cys Ala Arg Ile Val Pro Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln           
            100                 105                 110                   

ggg aca atg gtc acc gtc tct tcg                                        360
Gly Thr Met Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  53
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ile Ser Arg 
            20                  25                  30          


Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Gly Ile Tyr His Ser Gly Asn Thr Tyr Asp Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Val Pro Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  54
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NI-301.44E4 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(327)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  54
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg atc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca ggt att agt ggc agt ggc agt acg aca tac tac gca gac tcc gtg        192
Ser Gly Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc gcc atc tcc aga gac aaa tcc aag aac acg ctg tcc        240
Lys Gly Arg Phe Ala Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Ser           
65                  70                  75                  80            

cta caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aaa ggg gca tgg gag ata ccc acc tac ttt gac aac tgg ggc cag        336
Ala Lys Gly Ala Trp Glu Ile Pro Thr Tyr Phe Asp Asn Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  55
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Trp Glu Ile Pro Thr Tyr Phe Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  56
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  NI-301.44E4 VK variable light-kappa chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(297)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  56
gaa att gtg ctg act cag tct cca gcc acc ctg tct gtg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt att agg aac aac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Arg Asn Asn           
            20                  25                  30                    

tta gcc tgg tac cag cag aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat ggt gca tcc acc agg gcc act ggt atc cca gcc agg ttc agt ggc        192
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly           
    50                  55                  60                            

act ggg tct ggg aca gag ttc act ctc atc gtc agc agc ctg cag tct        240
Thr Gly Ser Gly Thr Glu Phe Thr Leu Ile Val Ser Ser Leu Gln Ser           
65                  70                  75                  80            

gaa gat ttt gca gtt tat tac tgt cag cag tat aat aac tgg cct ccc        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro           
                85                  90                  95                

acg tgg acg ttc ggc caa ggg acc aag gtg gaa atc aaa                    327
Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                       
            100                 105                                       


<210>  57
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Arg Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Glu Phe Thr Leu Ile Val Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-301.59F1 antibody, aa 61to aa 68 after alanine scan


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  58

Glu Glu Phe Xaa Glu Gly Ile Tyr 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-301.35G11 antibody, aa 54 to aa 61 after alanine 
       scan


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  59

Glu Leu Xaa Gly Leu Thr Xaa Glu 
1               5               


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of NI-301.37F1 antibody, aa 41 to aa 45 after alanine 
       scan

<400>  60

Trp Glu Pro Phe Ala 
1               5   


<210>  61
<211>  375
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(375)
<223>  NI-301.18C4 VH variable heavy chain (VH) sequence

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(342)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  61
gag gtg cag ctg gtg gag tct ggg gga acc ttg gtc cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg agg ctc tcc tgc gca gcg tcg gga ttc aca ttc aac att tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr           
            20                  25                  30                    

gcc atg acc tgg gtc cgc ctg tct cca gtg agg gga ctg gag tgg gtc        144
Ala Met Thr Trp Val Arg Leu Ser Pro Val Arg Gly Leu Glu Trp Val           
        35                  40                  45                        

tct act att act agt ggt ggc gtc agc ata tat tac gca gac tcc ata        192
Ser Thr Ile Thr Ser Gly Gly Val Ser Ile Tyr Tyr Ala Asp Ser Ile           
    50                  55                  60                            

aag ggc cgc ttc acc gtc tcc aga gac aat gcc aag aac atg gtg ttt        240
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Val Phe           
65                  70                  75                  80            

cta caa ctg gac aac ctg aca gtc gat gac acg gcc ata tat tac tgt        288
Leu Gln Leu Asp Asn Leu Thr Val Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

ggg aag gac gga aac tgc gat gag aca agt tgt tac tta agg ggg atg        336
Gly Lys Asp Gly Asn Cys Asp Glu Thr Ser Cys Tyr Leu Arg Gly Met           
            100                 105                 110                   

gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tcg                    375
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  62
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Leu Ser Pro Val Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Thr Ser Gly Gly Val Ser Ile Tyr Tyr Ala Asp Ser Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Val Phe 
65                  70                  75                  80  


Leu Gln Leu Asp Asn Leu Thr Val Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Lys Asp Gly Asn Cys Asp Glu Thr Ser Cys Tyr Leu Arg Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  63
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  NI-301.18C4 VL variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  63
cag tct gtg ttg acg cag ccg ccc tca gtg tca gcg gcc cca gga cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln           
1               5                   10                  15                

aag gtc acc atc tcc tgc tct ggt agc agg tcc gac att ggg tct aaa         96
Lys Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asp Ile Gly Ser Lys           
            20                  25                  30                    

ctt gtt tcc tgg tac cag gta atc cca gga aga gcc ccc cgg ctc gtc        144
Leu Val Ser Trp Tyr Gln Val Ile Pro Gly Arg Ala Pro Arg Leu Val           
        35                  40                  45                        

att ttt gac act tat aag cgg ccc tca ggg gta cct gcc cgc ttc tct        192
Ile Phe Asp Thr Tyr Lys Arg Pro Ser Gly Val Pro Ala Arg Phe Ser           
    50                  55                  60                            

gcc tcc aag tct ggc acg tca gcc acc ctg gac atc gcc ggg ctc cag        240
Ala Ser Lys Ser Gly Thr Ser Ala Thr Leu Asp Ile Ala Gly Leu Gln           
65                  70                  75                  80            

cct ggg gac gag gcc gaa tat ttc tgc gga tca tgg ggt aac agt gag        288
Pro Gly Asp Glu Ala Glu Tyr Phe Cys Gly Ser Trp Gly Asn Ser Glu           
                85                  90                  95                

aat ttt tat tat gtc ttc gga tct ggg acc cgg gtc acc gtc ctg            333
Asn Phe Tyr Tyr Val Phe Gly Ser Gly Thr Arg Val Thr Val Leu               
            100                 105                 110                   


<210>  64
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asp Ile Gly Ser Lys 
            20                  25                  30          


Leu Val Ser Trp Tyr Gln Val Ile Pro Gly Arg Ala Pro Arg Leu Val 
        35                  40                  45              


Ile Phe Asp Thr Tyr Lys Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Ala Thr Leu Asp Ile Ala Gly Leu Gln 
65                  70                  75                  80  


Pro Gly Asp Glu Ala Glu Tyr Phe Cys Gly Ser Trp Gly Asn Ser Glu 
                85                  90                  95      


Asn Phe Tyr Tyr Val Phe Gly Ser Gly Thr Arg Val Thr Val Leu 
            100                 105                 110     


<210>  65
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)
<223>  NI-301.11A10 variable heavy chain (VH) sequence (PIMC by default)

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(321)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  65
cag ctg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtg tct ggt ggc tcc atc agc agt aga         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Arg           
            20                  25                  30                    

agt tac tac tgg ggc tgg atg cgc cag ccc cca ggg aag ggg ctg gag        144
Ser Tyr Tyr Trp Gly Trp Met Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg agt att tat tat agt ggg agc acc ctc tac aat ccg tcc        192
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Leu Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtc acc atg tca ata gtc acg tcg agg aac cag ttc        240
Leu Lys Ser Arg Val Thr Met Ser Ile Val Thr Ser Arg Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ctg agt tct gtg acc gcc gcg gac acg gcc gtg tat tat        288
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt acc cga atg ggg gag ggg ggg cgg gac tac tgg ggc cag gga acc        336
Cys Thr Arg Met Gly Glu Gly Gly Arg Asp Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tcc tcg                                                354
Leu Val Thr Val Ser Ser                                                   
        115                                                               


<210>  66
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Arg 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Met Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Leu Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Ile Val Thr Ser Arg Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Met Gly Glu Gly Gly Arg Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  67
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  NI-301.11A10 variable K-light chain (VK) sequence

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VK-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VK-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VK-CDR3

<400>  67
gac atc cag atg acc cag tct cct tcc acc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gcc agt cag agt att agt agt tgg         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp           
            20                  25                  30                    

ttg gcc tgg tat cag cag aaa cca ggg aaa gcc cct aag gtc ctg atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile           
        35                  40                  45                        

tat gat gcc tcc agt ttg gaa aga ggg gtc cca tca agg ttc agc ggc        192
Tyr Asp Ala Ser Ser Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gaa ttc act ctc acc atc agc agc ctg cag cct        240
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gat gat tct gca act tat tac tgc caa cac tat aat ggt tat tca agg        288
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln His Tyr Asn Gly Tyr Ser Arg           
                85                  90                  95                

acg ttc ggc cgc ggg acc aag gtg gaa atc aaa                            321
Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  68
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ser Ala Thr Tyr Tyr Cys Gln His Tyr Asn Gly Tyr Ser Arg 
                85                  90                  95      


Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-301.3C9 variable heavy chain (VH) sequence (PIMC by default)

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  69
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag tct tcg cag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Ser Ser Gln           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct ggt gcc tcc ttc acc agg ggt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Phe Thr Arg Gly           
            20                  25                  30                    

gat ttc tac tgg agt tgg atc cgc cag gtc cca ggg aag ggc ctg gaa        144
Asp Phe Tyr Trp Ser Trp Ile Arg Gln Val Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggt tac ata tat tcc act ggg gac gtc tac tac aat ccg tct        192
Trp Ile Gly Tyr Ile Tyr Ser Thr Gly Asp Val Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gca aac atc tcg gtc gac acg ccc aag aag cag ttc        240
Leu Lys Ser Arg Ala Asn Ile Ser Val Asp Thr Pro Lys Lys Gln Phe           
65                  70                  75                  80            

ttc ctg aaa ttg acc tct ttg act gcc gca gac acg gcc gtc tat ttt        288
Phe Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Phe           
                85                  90                  95                

tgt gcc agg gaa gga caa tat tgt agc ggt ggt agt tgc tac cct gaa        336
Cys Ala Arg Glu Gly Gln Tyr Cys Ser Gly Gly Ser Cys Tyr Pro Glu           
            100                 105                 110                   

tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  70
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Phe Thr Arg Gly 
            20                  25                  30          


Asp Phe Tyr Trp Ser Trp Ile Arg Gln Val Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Ser Thr Gly Asp Val Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ala Asn Ile Ser Val Asp Thr Pro Lys Lys Gln Phe 
65                  70                  75                  80  


Phe Leu Lys Leu Thr Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Glu Gly Gln Tyr Cys Ser Gly Gly Ser Cys Tyr Pro Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  71
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  NI-301.3C9 variable light chain (VL) sequence (PIMC by default)

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(288)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  71
tcc tat gag ctg act cag cca ccc tca gtg tcc gtg tcc cca gga cag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

aca gcc acc atc acc tgc tct gga gat aat ttg gga cat aaa ttt act         96
Thr Ala Thr Ile Thr Cys Ser Gly Asp Asn Leu Gly His Lys Phe Thr           
            20                  25                  30                    

tgc tgg tat cag cag aag cca ggc cag tcc cct gtc ctg gtc atc tat        144
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr           
        35                  40                  45                        

caa gat cac aag cgg ccc tca ggg atc cct gag cga ttc tcc ggc tcc        192
Gln Asp His Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aac tct ggg gac aca gcc act ctg acc atc agc ggg acc cag gct atg        240
Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met           
65                  70                  75                  80            

gat gag gct gag tat tac tgt cag gcg tgg gcc ttc ccc tat gtg gtc        288
Asp Glu Ala Glu Tyr Tyr Cys Gln Ala Trp Ala Phe Pro Tyr Val Val           
                85                  90                  95                

ttc ggc gga ggg acc aag ctg acc gtc cta                                318
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                                   
            100                 105                                       


<210>  72
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  72

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ser Gly Asp Asn Leu Gly His Lys Phe Thr 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp His Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Glu Tyr Tyr Cys Gln Ala Trp Ala Phe Pro Tyr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  73
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  NI-301.14D8 variable heavy chain (VH) sequence (not PIMC)

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  73
gag gtg cag ctg gtg gag act ggg gga cgc ttg gtc cag ccg ggg ggg         48
Glu Val Gln Leu Val Glu Thr Gly Gly Arg Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc gtg aga ctc tcc tgt ata gcc tct gga ttt ccc ttt agg aat tat         96
Ser Val Arg Leu Ser Cys Ile Ala Ser Gly Phe Pro Phe Arg Asn Tyr           
            20                  25                  30                    

tgg atg agt tgg gtc cgc cag cct cca ggg aag ggg ctg gag tgg gtg        144
Trp Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gcc aac ata aag gaa gat ggc agt gac aga tac tat gtg gac tct gtg        192
Ala Asn Ile Lys Glu Asp Gly Ser Asp Arg Tyr Tyr Val Asp Ser Val           
    50                  55                  60                            

aag ggc cgc ttc acc atc ttt aga gac aac gcc aag aat ttt ctg agt        240
Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Phe Leu Ser           
65                  70                  75                  80            

cta caa atg aat cgc ctg aga gcc gag gac acg gcg gta tac ttc tgt        288
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aga att gta ggg gta atc ccg tcc gct gac cca tac tac ctt gac        336
Ala Arg Ile Val Gly Val Ile Pro Ser Ala Asp Pro Tyr Tyr Leu Asp           
            100                 105                 110                   

tcc tgg ggc cag gga acc ctg gtc acc gtc tcc tcg                        372
Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  74
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  74

Glu Val Gln Leu Val Glu Thr Gly Gly Arg Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ile Ala Ser Gly Phe Pro Phe Arg Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Asp Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Phe Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ile Val Gly Val Ile Pro Ser Ala Asp Pro Tyr Tyr Leu Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  75
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  NI-301.14D8 variable light chain (VL) sequence (PIMC by default)

<220>
<221>  V_region
<222>  (67)..(108)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (154)..(174)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (271)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  75
cag tct gcc ctg act cag cct gcc tcc gtg tct ggg ttt gct gga cag         48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Phe Ala Gly Gln           
1               5                   10                  15                

tcg gtc acc atc tcc tgc act gga acc agc ctt aac att ggg act tac         96
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Leu Asn Ile Gly Thr Tyr           
            20                  25                  30                    

aac ctt atc tcc tgg tac caa caa cac cca ggc aga gcc ccc aga ctc        144
Asn Leu Ile Ser Trp Tyr Gln Gln His Pro Gly Arg Ala Pro Arg Leu           
        35                  40                  45                        

atc att ttt gag ggc aat agg cgg ccc ccc ggg att tct aat cgc ttc        192
Ile Ile Phe Glu Gly Asn Arg Arg Pro Pro Gly Ile Ser Asn Arg Phe           
    50                  55                  60                            

tct gcc tcc aag tct ggc aac acg gcc tcc ttg aca gtc tct ggg ctg        240
Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu           
65                  70                  75                  80            

ctg gct ggc gac gag gct gat tat tac tgt tgc tca ttt gca gga aga        288
Leu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Gly Arg           
                85                  90                  95                

gtc tct ttg gtg ttt ggc gga ggg acc aag ttg acc gtc cta                330
Val Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  76
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  76

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Phe Ala Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Leu Asn Ile Gly Thr Tyr 
            20                  25                  30          


Asn Leu Ile Ser Trp Tyr Gln Gln His Pro Gly Arg Ala Pro Arg Leu 
        35                  40                  45              


Ile Ile Phe Glu Gly Asn Arg Arg Pro Pro Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Leu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Gly Arg 
                85                  90                  95      


Val Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  77
<211>  348
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(348)
<223>  NI-301.9X4 variable heavy chain (VH) sequence (PIMC by default)

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(315)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  77
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aaa cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc agt gtc tct gct ggc tcc atc agt agt cac         96
Thr Leu Ser Leu Thr Cys Ser Val Ser Ala Gly Ser Ile Ser Ser His           
            20                  25                  30                    

tac tgg aac tgg atc cgg cag ccc cca ggg aag gga ctg gaa tgg att        144
Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg tct atc tat cac agt ggg agc acc aac tac aac ccc tcc ctc aag        192
Gly Ser Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys           
    50                  55                  60                            

agt cga gtc acc ata tca gta gac acg tcc aag aac cac gtc tcc ctg        240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Val Ser Leu           
65                  70                  75                  80            

agg ttg acg tct gtg acc gcc gca gac acg gcc gtg tat tac tgt gcg        288
Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga gac tac tac tac tac atg gac gtc tgg ggc aaa ggg acc acg gtc        336
Arg Asp Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val           
            100                 105                 110                   

acc gtc tcc tcg                                                        348
Thr Val Ser Ser                                                           
        115                                                               


<210>  78
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Ala Gly Ser Ile Ser Ser His 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Val Ser Leu 
65                  70                  75                  80  


Arg Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  79
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-301.9X4 variable light chain (VL) sequence (PIMC by default)

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(294)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  79
tcc tat gag ctg act cag cca ccc tcg gtg tca gtg tcc cca gga cag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acg gcc agg atc acc tgc tct gga gat gcg ttg cca gac aag tat gct         96
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Asp Lys Tyr Ala           
            20                  25                  30                    

tat tgg tac cag cag aag cca ggc cag gcc cct atg ttg gtt ata tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Met Leu Val Ile Tyr           
        35                  40                  45                        

aag gac agt gag agg ccc tca ggg atc cct gag cga ttc tct ggc tcc        192
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

agt ttg ggg aca aca gtc atg ctg acc atc agt gga gtc cag gca gag        240
Ser Leu Gly Thr Thr Val Met Leu Thr Ile Ser Gly Val Gln Ala Glu           
65                  70                  75                  80            

gac gag gct gac tat tac tgt aaa tca gca gac agc agt ggt act tat        288
Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Ala Asp Ser Ser Gly Thr Tyr           
                85                  90                  95                

tgg gtg ttc ggc ggg ggg acc aag ctg acc gtc cta                        324
Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                           
            100                 105                                       


<210>  80
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  80

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Met Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Leu Gly Thr Thr Val Met Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Lys Ser Ala Asp Ser Ser Gly Thr Tyr 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  81
<211>  363
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(363)
<223>  NI-301.14C3 variable heavy chain (VH) sequence (PIMC by default)

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(195)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (292)..(330)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  81
gag gtg cag ctg gtg gag act gga gga ggc ttg atc cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct ggg ttc acc gtc agt agc cac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser His           
            20                  25                  30                    

tac atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca att att tat agc ggt ggt ggc aca tac tac gca gac tcc gtg aag        192
Ser Ile Ile Tyr Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys           
    50                  55                  60                            

ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu           
65                  70                  75                  80            

caa atg aac agc ctg aga gcc gag gac acg gcc gtg tat tac tgt gcg        288
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aag atc tac agg tcg ggt aat act ggt tat tct tac gac tac tgg ggc        336
Lys Ile Tyr Arg Ser Gly Asn Thr Gly Tyr Ser Tyr Asp Tyr Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc tcg                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  82
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  82

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser His 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ile Tyr Arg Ser Gly Asn Thr Gly Tyr Ser Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  83
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  NI-301.14C3 variable light chain (VL) sequence

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(294)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  83
tcc tat gag ctg act cag cca ccc tca gtg tcc gtg tcc cca ggg cag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

aca gcc agc atc acc tgc tct gga gat aaa ttg ggg agt aaa tat gct         96
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Ser Lys Tyr Ala           
            20                  25                  30                    

tgc tgg tat cag cag aag cca ggc cag tcc cct gta ctg gtc atc tat        144
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr           
        35                  40                  45                        

gaa gat aag aag cgg ccc tca ggg atc cct gag cga ttc tct ggc tcc        192
Glu Asp Lys Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aac tct ggg aac aca gcc act ctg acc atc agc ggg acc cag gct atg        240
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met           
65                  70                  75                  80            

gat gag gct gac tat ttc tgt cag gcg tgg gac agc agc act tct cat        288
Asp Glu Ala Asp Tyr Phe Cys Gln Ala Trp Asp Ser Ser Thr Ser His           
                85                  90                  95                

gtg gta ttc ggc gga ggg acc agg ctg acc gtc cta                        324
Val Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu                           
            100                 105                                       


<210>  84
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  84

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Ser Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Lys Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Ala Trp Asp Ser Ser Thr Ser His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence recognized by NI-301.59F1 in the epitope mapping
       - Spot 15

<400>  85

Gly Leu Thr Thr Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence recognized by NI-301.59F1 in the epitope mapping
       - Spot 16

<400>  86

Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence recognized by NI-301.35G11 in the epitope 
       mapping - Spot 13

<400>  87

Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence recognized by NI-301.35G11 in the epitope 
       mapping - Spot 14

<400>  88

Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe Val Glu Gly 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence recognized by NI-301.37F1 in the epitope mapping
       - Spot 9

<400>  89

Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence recognized by NI-301.37F1 in the epitope mapping
       - Spot 10

<400>  90

Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys Thr Ser Glu 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence recognized by NI-301.37F1 in the epitope mapping
       - Spot 11

<400>  91

Trp Glu Pro Phe Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu 
1               5                   10                  15  


