                         SEQUENCE LISTING

<110>  Uniwersytet Warszawski
 
<120>  Rekombinowane biako fuzyjne ProSTAToraz jego zastosowania

<130>  PZ/2206/AGR/PCT

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  1
gactgtgagg tcaacaacgg ttccagcctc agggatgagt gcatcacaaa cctactggtg       60

tttggcttcc tccaaagctg ttctgacaac agcttccgca gagagctgga cgcactgggc      120

cacgagctgc cagtgctggc tccccagtgg gagggctacg atgagctgca gactgatggc      180

aaccgcagca gccactcccg cttgggaaga atagaggcag attctgaaag tcaagaagac      240

atcatccgga atattgccag gcacctcgcc caggtcgggg acagcatgga ccgtagcatc      300

cctccgggcc tggtgaacgg cctggccctg cagctcagga acaccagccg gtcggaggag      360

gaccggaaca gggacctggc cactgccctg gagcagctgc tgcaggccta ccctagagac      420

atggagaagg agaagaccat gctggtgctg gccctgctgc tggccaagaa ggtggccagt      480

caaacgccgt ccttgctccg tgatgtcttt cacacaacag tgaactttat taaccagaac      540

ctacgcacct acgtgaggag cttagccaga aatgggatgg ac                         582


<210>  2
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile Thr 
1               5                   10                  15      


Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser Phe 
            20                  25                  30          


Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala Pro 
        35                  40                  45              


Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser Ser 
    50                  55                  60                  


His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu Asp 
65                  70                  75                  80  


Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met 
                85                  90                  95      


Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln Leu 
            100                 105                 110         


Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala Thr 
        115                 120                 125             


Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu 
    130                 135                 140                 


Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser 
145                 150                 155                 160 


Gln Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn Phe 
                165                 170                 175     


Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn Gly 
            180                 185                 190         


Met Asp 
        


<210>  3
<211>  33
<212>  DNA
<213>  Human immunodeficiency virus

<400>  3
tacggccgca agaaacgccg ccagcgccgc aga                                    33


<210>  4
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus

<400>  4

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  5
<211>  804
<212>  DNA
<213>  artificial

<220>
<223>  Nucleotide seq of ProSTAT

<400>  5
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atgtacggcc gcaagaaacg ccgccagcgc cgcagaggag aattcgactg tgaggtcaac      120

aacggttcca gcctcaggga tgagtgcatc acaaacctac tggtgtttgg cttcctccaa      180

agctgttctg acaacagctt ccgcagagag ctggacgcac tgggccacga gctgccagtg      240

ctggctcccc agtgggaggg ctacgatgag ctgcagactg atggcaaccg cagcagccac      300

tcccgcttgg gaagaataga ggcagattct gaaagtcaag aagacatcat ccggaatatt      360

gccaggcacc tcgcccaggt cggggacagc atggaccgta gcatccctcc gggcctggtg      420

aacggcctgg ccctgcagct caggaacacc agccggtcgg aggaggaccg gaacagggac      480

ctggccactg ccctggagca gctgctgcag gcctacccta gagacatgga gaaggagaag      540

accatgctgg tgctggccct gctgctggcc aagaaggtgg ccagtcaaac gccgtccttg      600

ctccgtgatg tctttcacac aacagtgaac tttattaacc agaacctacg cacctacgtg      660

aggagcttag ccagaaatgg gatggaccaa gcttgcggcc gctacccata cgatgttcct      720

gactatgcgg gctatcccta tgacgtcccc gactatgcag gatcctatcc atatgacgtt      780

ccagattacg ctgctcagtg ctga                                             804


<210>  6
<211>  267
<212>  PRT
<213>  artificial

<220>
<223>  Fusion protein

<400>  6

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  25                  30          


Gly Glu Phe Asp Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu 
        35                  40                  45              


Cys Ile Thr Asn Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp 
    50                  55                  60                  


Asn Ser Phe Arg Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val 
65                  70                  75                  80  


Leu Ala Pro Gln Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn 
                85                  90                  95      


Arg Ser Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser 
            100                 105                 110         


Gln Glu Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly 
        115                 120                 125             


Asp Ser Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala 
    130                 135                 140                 


Leu Gln Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp 
145                 150                 155                 160 


Leu Ala Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met 
                165                 170                 175     


Glu Lys Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys 
            180                 185                 190         


Val Ala Ser Gln Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr 
        195                 200                 205             


Val Asn Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala 
    210                 215                 220                 


Arg Asn Gly Met Asp Gln Ala Cys Gly Arg Tyr Pro Tyr Asp Val Pro 
225                 230                 235                 240 


Asp Tyr Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Tyr 
                245                 250                 255     


Pro Tyr Asp Val Pro Asp Tyr Ala Ala Gln Cys 
            260                 265         


<210>  7
<211>  325
<212>  PRT
<213>  artificial

<220>
<223>  AA sequence of fusion protein ODD-ProSTAT

<400>  7

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  25                  30          


Gly Glu Phe Asn Pro Phe Ser Thr Gln Asp Thr Asp Leu Asp Leu Glu 
        35                  40                  45              


Met Leu Ala Pro Tyr Ile Pro Met Asp Asp Asp Phe Gln Leu Arg Ser 
    50                  55                  60                  


Phe Asp Gln Leu Ser Pro Leu Glu Ser Ser Ser Ala Ser Pro Glu Ser 
65                  70                  75                  80  


Ala Ser Pro Gln Ser Thr Val Thr Val Phe Gln Glu Phe Asp Cys Glu 
                85                  90                  95      


Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile Thr Asn Leu Leu 
            100                 105                 110         


Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser Phe Arg Arg Glu 
        115                 120                 125             


Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala Pro Gln Trp Glu 
    130                 135                 140                 


Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser Ser His Ser Arg 
145                 150                 155                 160 


Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu Asp Ile Ile Arg 
                165                 170                 175     


Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met Asp Arg Ser 
            180                 185                 190         


Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln Leu Arg Asn Thr 
        195                 200                 205             


Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala Thr Ala Leu Glu 
    210                 215                 220                 


Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu Lys Thr Met 
225                 230                 235                 240 


Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser Gln Thr Pro 
                245                 250                 255     


Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn Phe Ile Asn Gln 
            260                 265                 270         


Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn Gly Met Asp Gln 
        275                 280                 285             


Ala Cys Gly Arg Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Tyr Pro 
    290                 295                 300                 


Tyr Asp Val Pro Asp Tyr Ala Gly Ser Tyr Pro Tyr Asp Val Pro Asp 
305                 310                 315                 320 


Tyr Ala Ala Gln Cys 
                325 


<210>  8
<211>  978
<212>  DNA
<213>  artificial

<220>
<223>  Nucleotide sequence of Ofusion protein ODD-ProSTAT

<400>  8
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atgtacggcc gcaagaaacg ccgccagcgc cgcagaggag aattcaaccc attttctact      120

caggacacag atttagactt ggagatgtta gctccctata tcccaatgga tgatgacttc      180

cagttacgtt ccttcgatca gttgtcacca ttagaaagca gttccgcaag ccctgaaagc      240

gcaagtcctc aaagcacagt tacagtattc caggaattcg actgtgaggt caacaacggt      300

tccagcctca gggatgagtg catcacaaac ctactggtgt ttggcttcct ccaaagctgt      360

tctgacaaca gcttccgcag agagctggac gcactgggcc acgagctgcc agtgctggct      420

ccccagtggg agggctacga tgagctgcag actgatggca accgcagcag ccactcccgc      480

ttgggaagaa tagaggcaga ttctgaaagt caagaagaca tcatccggaa tattgccagg      540

cacctcgccc aggtcgggga cagcatggac cgtagcatcc ctccgggcct ggtgaacggc      600

ctggccctgc agctcaggaa caccagccgg tcggaggagg accggaacag ggacctggcc      660

actgccctgg agcagctgct gcaggcctac cctagagaca tggagaagga gaagaccatg      720

ctggtgctgg ccctgctgct ggccaagaag gtggccagtc aaacgccgtc cttgctccgt      780

gatgtctttc acacaacagt gaactttatt aaccagaacc tacgcaccta cgtgaggagc      840

ttagccagaa atgggatgga ccaagcttgc ggccgctacc catacgatgt tcctgactat      900

gcgggctatc cctatgacgt cccggactat gcaggatcct atccatatga cgttccagat      960

tacgctgctc agtgctga                                                    978


<210>  9
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  starter BIDlong.EcoRI.For

<400>  9
cggaattcga ctgtgaggtc aacaacgg                                          28


<210>  10
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  starter BIDlong.HindIII.Rev

<400>  10
cccaagcttg gtccatccca tttctggcta agc                                    33


<210>  11
<211>  90
<212>  DNA
<213>  artificial

<220>
<223>  Nucleotide seq of 3x epitop HA

<400>  11
tacccatacg atgttcctga ctatgcgggc tatccctatg acgtccccga ctatgcagga       60

tcctatccat atgacgttcc agattacgct                                        90


<210>  12
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  AA sequence of 3x epitop HA

<400>  12

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Tyr Pro Tyr Asp Val Pro 
1               5                   10                  15      


Asp Tyr Ala Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            20                  25                  30  


<210>  13
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  starter HIF1549For

<400>  13
cggaattcaa cccattttct actcaggaca ca                                     32


<210>  14
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  starter HIF1603Rev

<400>  14
cggaattcct ggaatactgt aactgtgctt tg                                     32


