                         SEQUENCE LISTING

<110>  WANG, MING-HAI
 
<120>  ANTI-RON MONOCLONAL ANTIBODIES AS A CYTOTOXIC DRUG DELIVERY 
       SYSTEM FOR TARGETED CANCER THERAPY

<130>  TECH:2073WO

<140>  62/057,367
<141>  2014-09-30

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  1
atggaaaggc actggatctt tctcttcctg atttcagtaa ctgcaggtgt ccactcccag       60

gtccaacttc agcagtctgg ggctgaactg gcaaaacctg gggcctcagt gaagatgtcc      120

tgcaaggcgt ctggctacac ctttactagc tactggatgc actgggtaaa acagaggcct      180

ggacagggtc tggaatggat tggatacatt aatcctagca ctggttatat tgagtacaat      240

cagaacttca aggacaaggc cacattgact gcagacaaat cctccagcac agcctacatg      300

caactgagca gcctgacatc tgaggactct gcagtctatt actgtgcaag atccccctct      360

cattattacg gtagtaggta cggatatttc gatgtctggg gcgcagggac cacggtcacc      420

gtctcctca                                                              429


<210>  2
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Met Glu Arg His Trp Ile Phe Leu Phe Leu Ile Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Ile Glu Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Pro Ser His Tyr Tyr Gly Ser Arg Tyr Gly 
        115                 120                 125             


Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140             


<210>  3
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc       60

agaggacaaa ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag      120

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tgcactggta ccagcagaag      180

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagagtggag      300

gctgaagatg ctgccactta ttactgtcag cagtggagta gtaacccacg gacgttcggt      360

ggaggcacca agctggaaat caaa                                             384


<210>  4
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Ser Gln Ser Pro Ala Ile 
            20                  25                  30          


Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


<210>  5
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
gaggttcagc tgcagcagtc tggggcagaa cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacaa cttctggctt caacattata gacacctata tacactgggt gaatcagaag      120

cctgatcagg gcctggagtg gattggaagg attgaccctg cggatggtaa tagaaaatct      180

gacccgaagt tccaggtcaa ggccacaata actgttgaca catcctccaa cacagcctac      240

ctgcaactca gcagcctgac atctggggac actgccgtct attactgtgc cagagggtac      300

ggtaacctca atgctatgga ctcctggggt caaggaacct cagtcaccgt ctcctca         357


<210>  6
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Asn Ile 
        35                  40                  45              


Ile Asp Thr Tyr Ile His Trp Val Asn Gln Lys Pro Asp Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asp Gly Asn Arg Lys Ser Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Val Lys Ala Thr Ile Thr Val Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Tyr Gly Asn Leu Asn Ala Met Asp Ser Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  7
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  7
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60

gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttgggga cacaattacc      120

atcacttgcc atgccagtca gaacattaat gtttggttaa actggtatca gcagaaaccc      180

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      240

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      300

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atcctctgac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  8
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Asn Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Tyr Ile Asn Pro Ser Thr Gly Tyr Ile Glu Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Ser Pro Ser His Tyr Tyr Gly Ser Arg Tyr Gly Tyr Phe Asp Val 
1               5                   10                  15  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Gln Gln Trp Ser Ser Asn Pro Arg Thr 
1               5                   


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Gly Phe Asn Ile Ile Asp Thr Tyr Ile His 
1               5                   10  


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  16

Arg Ile Asp Pro Ala Asp Gly Asn Arg Lys Ser Asp Pro Lys Phe Gln 
1               5                   10                  15      


Val 
    


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Gly Tyr Gly Asn Leu Asn Ala Met Asp Ser 
1               5                   10  


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  18

His Ala Ser Gln Asn Ile Asn Val Trp Leu Asn 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  21
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggctacagtg      120

aaaatctcct gcaaggtttc tggatacacc ttcaccgaca cctatataca ctgggtgcaa      180

caggcccctg gaaaagggct tgagtggatg ggaaggattg accctgcgga tggtaataga      240

aaatctgacc cgaagttcca ggtcagagtc accataaccg cggacacgtc tacagacaca      300

gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcaaga      360

gggtacggta acctcaatgc tatggactcc tggggccaag gtaccctggt caccgtgtcg      420

agagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210>  22
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Thr Tyr Ile His Trp Val Gln Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asp Gly Asn Arg 
65                  70                  75                  80  


Lys Ser Asp Pro Lys Phe Gln Val Arg Val Thr Ile Thr Ala Asp Thr 
                85                  90                  95      


Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Asn Leu Asn Ala Met 
        115                 120                 125             


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  23
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  23
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcatc tggatacacc ttcaccgaca cctatataca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggaaggattg accctgcgga tggtaataga      240

aaatctgacc cgaagttcca ggtcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

gggtacggta acctcaatgc tatggactcc tggggccagg gaaccctggt caccgtctcc      420

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210>  24
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asp Gly Asn Arg 
65                  70                  75                  80  


Lys Ser Asp Pro Lys Phe Gln Val Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Asn Leu Asn Ala Met 
        115                 120                 125             


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  25
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  25
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagccagg tccagcttgt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactgaca cctatataca ctgggtgcgc      180

caggcccccg gacaaaggct tgagtggatg ggaaggattg accctgcgga tggtaataga      240

aaatctgacc cgaagttcca ggtcagagtc accattacca gggacacatc cgcgagcaca      300

gcctacatgg agctgagcag cctgagatct gaagacacgg ctgtgtatta ctgtgcgaga      360

gggtacggta acctcaatgc tatggactcc tggggccagg gaaccctggt caccgtctcc      420

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210>  26
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Arg Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asp Gly Asn Arg 
65                  70                  75                  80  


Lys Ser Asp Pro Lys Phe Gln Val Arg Val Thr Ile Thr Arg Asp Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Asn Leu Asn Ala Met 
        115                 120                 125             


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  27
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  27
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagccagg tccagctggt acagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggtttc cggatacacc ctcactgaca cctatataca ctgggtgcga      180

caggctcctg gaaaagggct tgagtggatg ggaaggattg accctgcgga tggtaataga      240

aaatctgacc cgaagttcca ggtcagagtc accatgaccg aggacacatc tacagacaca      300

gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcaaca      360

gggtacggta acctcaatgc tatggactcc tggggccaag ggacaatggt caccgtctct      420

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210>  28
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly 
        35                  40                  45              


Tyr Thr Leu Thr Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Ala Asp Gly Asn Arg 
65                  70                  75                  80  


Lys Ser Asp Pro Lys Phe Gln Val Arg Val Thr Met Thr Glu Asp Thr 
                85                  90                  95      


Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Thr Gly Tyr Gly Asn Leu Asn Ala Met 
        115                 120                 125             


Asp Ser Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  29
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  29
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagccagg tgcagctgca ggagtcgggc ccaggactgg tgaagccttc ggagaccctg      120

tccctcacct gcactgtctc tggtggctcc atcagtgaca cctatataca ctggatccgg      180

cagcccccag ggaagggact ggagtggatt gggaggattg accctgcgga tggtaataga      240

aaatctgacc cgaagttcca ggtccgagtc accatatcag tagacacgtc caagaaccag      300

ttctccctga agctgagctc tgtgaccgct gcggacacgg ccgtgtatta ctgtgcgaga      360

gggtacggta acctcaatgc tatggactcc tggggccaag ggacaatggt caccgtctct      420

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210>  30
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Asp Thr Tyr Ile His Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Ala Asp Gly Asn Arg 
65                  70                  75                  80  


Lys Ser Asp Pro Lys Phe Gln Val Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Gly Asn Leu Asn Ala Met 
        115                 120                 125             


Asp Ser Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  31
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  31
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccatgc cagtcagaac attaatgttt ggttaaactg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tacaaggctt ccaacttgca cacaggggtc      240

ccatcaaggt tcagtggaag tggatctggg acagatttta ctttcaccat cagcagcctg      300

cagcctgaag atattgcaac atattactgt caacagggtc aaagttatcc tctgacgttc      360

ggcggaggga ccaagctgga gatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210>  32
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser 
        35                  40                  45              


Gln Asn Ile Asn Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  33
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  33
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccatgc cagtcagaac attaatgttt ggttaaactg gtatcagcag      180

aaaccaggga aagcccctaa gctcctgatc tataaggctt ccaacttgca cacaggggtc      240

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      300

caacctgaag attttgcaac ttactactgt caacagggtc aaagttatcc tctgacgttc      360

ggcggaggga ccaagctgga gatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210>  34
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser 
        35                  40                  45              


Gln Asn Ile Asn Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  35
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  35
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccatgc cagtcagaac attaatgttt ggttaaactg gtatcagcag      180

aaaccaggga aagttcctaa gctcctgatc tataaggctt ccaacttgca cacaggggtc      240

ccatctcggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagcctg      300

cagcctgaag atgttgcaac ttattactgt caacagggtc aaagttatcc tctgacgttc      360

ggcggaggga ccaaggtgga gatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210>  36
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser 
        35                  40                  45              


Gln Asn Ile Asn Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Val Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  37
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  37
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagcgaca tccaggtgac ccagtctcca tccttcctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccatgc cagtcagaac attaatgttt ggttaaactg gtatcagcaa      180

aaaccaggga aagcccctaa gctcctgatc tataaggctt ccaacttgca cacaggggtc      240

ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg      300

cagcctgaag attttgcaac ttattactgt caacagggtc aaagttatcc tctgacgttc      360

ggcggaggga ccaaggtgga gatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210>  38
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  38

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Asp Ile Gln Val Thr Gln Ser Pro Ser Phe 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser 
        35                  40                  45              


Gln Asn Ile Asn Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  39
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  39
gccgccacca tgggctggag ctggatcctg ctgttcctcc tgagcgtgac agcaggagtg       60

cacagcgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccatgc cagtcagaac attaatgttt ggttaaactg gtatcagcag      180

aaaccaggga aagcccctaa gcgcctgatc tataaggctt ccaacttgca cacaggggtc      240

ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcacaat cagcagcctg      300

cagcctgaag attttgcaac ttattactgt caacagggtc aaagttatcc tctgacgttc      360

ggcggaggga ccaaggtgga gatcaaacga acggtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta g               711


<210>  40
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  40

Ala Ala Thr Met Gly Trp Ser Trp Ile Leu Leu Phe Leu Leu Ser Val 
1               5                   10                  15      


Thr Ala Gly Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ala Ser 
        35                  40                  45              


Gln Asn Ile Asn Val Trp Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Arg Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


