                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> CRP CAPTURE/DETECTION OF GRAM POSITIVE BACTERIA

<130> 002806-080011-PCT

<140> PCT/US2014/071293
<141> 2014-12-18

<150> 61/917,705
<151> 2013-12-18

<160> 53    

<170> PatentIn version 3.5

<210> 1
<211> 224
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210> 2
<211> 225
<212> PRT
<213> Mus musculus

<400> 2
Met Glu Lys Leu Leu Trp Cys Leu Leu Ile Met Ile Ser Phe Ser Arg 
1               5                   10                  15      


Thr Phe Gly His Glu Asp Met Phe Lys Lys Ala Phe Val Phe Pro Lys 
            20                  25                  30          


Glu Ser Asp Thr Ser Tyr Val Ser Leu Glu Ala Glu Ser Lys Lys Pro 
        35                  40                  45              


Leu Asn Thr Phe Thr Val Cys Leu His Phe Tyr Thr Ala Leu Ser Thr 
    50                  55                  60                  


Val Arg Ser Phe Ser Val Phe Ser Tyr Ala Thr Lys Lys Asn Ser Asn 
65                  70                  75                  80  


Asp Ile Leu Ile Phe Trp Asn Lys Asp Lys Gln Tyr Thr Phe Gly Val 
                85                  90                  95      


Gly Gly Ala Glu Val Arg Phe Met Val Ser Glu Ile Pro Glu Ala Pro 
            100                 105                 110         


Thr His Ile Cys Ala Ser Trp Glu Ser Ala Thr Gly Ile Val Glu Phe 
        115                 120                 125             


Trp Ile Asp Gly Lys Pro Lys Val Arg Lys Ser Leu His Lys Gly Tyr 
    130                 135                 140                 


Thr Val Gly Pro Asp Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser 
145                 150                 155                 160 


Tyr Gly Gly Asp Phe Asp Ala Lys Gln Ser Leu Val Gly Asp Ile Gly 
                165                 170                 175     


Asp Val Asn Met Trp Asp Phe Val Leu Ser Pro Glu Gln Ile Ser Thr 
            180                 185                 190         


Val Tyr Val Gly Gly Thr Leu Ser Pro Asn Val Leu Asn Trp Arg Ala 
        195                 200                 205             


Leu Asn Tyr Lys Ala Gln Gly Asp Val Phe Ile Lys Pro Gln Leu Trp 
    210                 215                 220                 


Ser 
225 


<210> 3
<211> 201
<212> PRT
<213> Homo sapiens

<400> 3
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys 
        195                 200     


<210> 4
<211> 206
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Ala Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Ala Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
        195                 200                 205     


<210> 5
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala 
225                 230         


<210> 6
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210> 7
<211> 263
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala Pro Asp Gly Asp Ser Ser Leu Ala 
225                 230                 235                 240 


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
                245                 250                 255     


Trp Leu Thr Phe Ser Leu Gly 
            260             


<210> 8
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile 
                245             


<210> 9
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala Val Ile 
1               5                   10                  15      


Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp Gly Arg 
            20                  25                  30          


Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu Arg Gly 
        35                  40                  45              


Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro 
    50                  55                  60                  


Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly Lys Ser 
65                  70                  75                  80  


Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln 
                85                  90                  95      


Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys 
            100                 105                 110         


Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe 
        115                 120                 125             


Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr 
    130                 135                 140                 


Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu 
145                 150                 155                 160 


Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val 
                165                 170                 175     


Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu 
            180                 185                 190         


Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn 
        195                 200                 205             


Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys 
    210                 215                 220                 


Glu Phe Pro Ile 
225             


<210> 10
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser 
            20  


<210> 11
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys 
1               5                   10                  15      


Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe 
            20                  25                  30          


Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys 
        35                  40                  45              


Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn 
    50                  55                  60                  


Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr 
65                  70                  75                  80  


Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu 
                85                  90                  95      


Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp 
            100                 105                 110         


Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro 
        115                 120                 125             


Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
    130                 135                 140     


<210> 12
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu 
1               5                   10                  15      


Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro 
            20                  25                  30          


Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu 
        35                  40                  45              


Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp 
    50                  55                  60                  


Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro 
65                  70                  75                  80  


Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly 
                85                  90                  95      


Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu 
            100                 105                 110         


Phe Pro Ile 
        115 


<210> 13
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid 

<400> 13
Glu Xaa Asn 
1           


<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser 
1               5                   10  


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Ser Asp Glu Asp Cys Val Leu Leu 
1               5                   


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr 
1               5                   10                  15  


<210> 17
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Glu Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu 
1               5                   10                  15      


Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser 
            20                  25          


<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Lys Leu Gly 
1               


<210> 19
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly Asn 
1               5                   10      


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu 
1               5                   10  


<210> 21
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Lys Leu Gly Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser 
1               5                   10                  


<210> 22
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 23
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln 
1               5                   10                  15      


Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys 
            20                  25                  30          


Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe 
        35                  40                  45              


Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr 
    50                  55                  60                  


Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu 
65                  70                  75                  80  


Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val 
                85                  90                  95      


Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu 
            100                 105                 110         


Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn 
        115                 120                 125             


Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val Cys 
    130                 135                 140                 


Glu Phe Pro Ile 
145             


<210> 24
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala Pro Asp Gly Asp Ser Ser Leu Ala 
225                 230                 235                 240 


Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys 
                245                 250                 255     


Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu 
            260                 265                 270         


Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val 
        275                 280                 285             


Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly 
    290                 295                 300                 


Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp 
305                 310                 315                 320 


Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr 
                325                 330                 335     


Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu 
            340                 345                 350         


Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys 
        355                 360                 365             


Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
    370                 375                 380 


<210> 25
<211> 383
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Ala Lys Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Pro Asp Gly Asp Ser 
225                 230                 235                 240 


Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg 
                245                 250                 255     


Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys Gln Val Gly Asn Lys 
            260                 265                 270         


Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala 
        275                 280                 285             


Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala 
    290                 295                 300                 


Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly 
305                 310                 315                 320 


Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn 
                325                 330                 335     


Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly 
            340                 345                 350         


Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp 
        355                 360                 365             


Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
    370                 375                 380             


<210> 26
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala Thr Ser Lys Gln Val Gly Asn Lys 
225                 230                 235                 240 


Phe Phe Leu Thr Asn Gly Glu Ile Met Thr Phe Glu Lys Val Lys Ala 
                245                 250                 255     


Leu Cys Val Lys Phe Gln Ala Ser Val Ala Thr Pro Arg Asn Ala Ala 
            260                 265                 270         


Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys Glu Glu Ala Phe Leu Gly 
        275                 280                 285             


Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe Val Asp Leu Thr Gly Asn 
    290                 295                 300                 


Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly Glu Pro Asn Asn Ala Gly 
305                 310                 315                 320 


Ser Asp Glu Asp Cys Val Leu Leu Leu Lys Asn Gly Gln Trp Asn Asp 
                325                 330                 335     


Val Pro Cys Ser Thr Ser His Leu Ala Val Cys Glu Phe Pro Ile 
            340                 345                 350     


<210> 27
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr 
1               5                   10                  15      


Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala 
            20                  25                  30          


Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys 
        35                  40                  45              


Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe 
    50                  55                  60                  


Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly 
65                  70                  75                  80  


Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys 
                85                  90                  95      


Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val 
            100                 105                 110         


Cys Glu Phe Pro Ile 
        115         


<210> 28
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln 
1               5                   10                  15      


Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly Lys 
            20                  25                  30          


Gln 
    


<210> 29
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ala Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu 
1               5                   10                  15      


Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly 
            20                  25                  30          


Lys Gln 
        


<210> 30
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu Gln 
1               5                   10                  15      


Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly 
            20                  25                  30      


<210> 31
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Ala Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala Leu 
1               5                   10                  15      


Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu Gly 
            20                  25                  30          


<210> 32
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Ala Lys Thr 
1           


<210> 33
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (232)..(251)
<223> Any amino acid and this region may encompass 0 to 20 residues,
      wherein some positions may be absent

<400> 33
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Thr Asp Met Ser 
                245                 250                 255     


Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp Thr Ser Tyr Val Ser 
            260                 265                 270         


Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala Phe Thr Val Cys Leu 
        275                 280                 285             


His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly Tyr Ser Ile Phe Ser 
    290                 295                 300                 


Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu Ile Phe Trp Ser Lys 
305                 310                 315                 320 


Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser Glu Ile Leu Phe Glu 
                325                 330                 335     


Val Pro Glu Val Thr Val Ala Pro Val His Ile Cys Thr Ser Trp Glu 
            340                 345                 350         


Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp Gly Lys Pro Arg Val 
        355                 360                 365             


Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly Ala Glu Ala Ser Ile 
    370                 375                 380                 


Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly Asn Phe Glu Gly Ser 
385                 390                 395                 400 


Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn Met Trp Asp Phe Val 
                405                 410                 415     


Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser 
            420                 425                 430         


Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln Gly Glu 
        435                 440                 445             


Val Phe Thr Lys 
    450         


<210> 34
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (232)..(251)
<223> Any amino acid and this region may encompass 0 to 20 residues,
      wherein some positions may be absent

<400> 34
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Thr Asp Met Ser 
                245                 250                 255     


Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp Thr Ser Tyr Val Ser 
            260                 265                 270         


Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala Phe Thr Val Ala Leu 
        275                 280                 285             


His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly Tyr Ser Ile Phe Ser 
    290                 295                 300                 


Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu Ile Phe Trp Ser Lys 
305                 310                 315                 320 


Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser Glu Ile Leu Phe Glu 
                325                 330                 335     


Val Pro Glu Val Thr Val Ala Pro Val His Ile Ala Thr Ser Trp Glu 
            340                 345                 350         


Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp Gly Lys Pro Arg Val 
        355                 360                 365             


Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly Ala Glu Ala Ser Ile 
    370                 375                 380                 


Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly Asn Phe Glu Gly Ser 
385                 390                 395                 400 


Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn Met Trp Asp Phe Val 
                405                 410                 415     


Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser 
            420                 425                 430         


Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln Gly Glu 
        435                 440                 445             


Val Phe Thr Lys Pro Gln Leu Trp Pro 
    450                 455         


<210> 35
<211> 343
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (207)..(226)
<223> Any amino acid and this region may encompass 0 to 20 residues,
      wherein some positions may be absent

<400> 35
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile 
225                 230                 235                 240 


Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser 
                245                 250                 255     


Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu 
            260                 265                 270         


Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly 
        275                 280                 285             


Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn 
    290                 295                 300                 


Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu 
305                 310                 315                 320 


Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu 
                325                 330                 335     


Ala Val Cys Glu Phe Pro Ile 
            340             


<210> 36
<211> 343
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (118)..(137)
<223> Any amino acid and this region may encompass 0 to 20 residues,
      wherein some positions may be absent

<400> 36
Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met Thr 
1               5                   10                  15      


Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val Ala 
            20                  25                  30          


Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile Lys 
        35                  40                  45              


Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln Phe 
    50                  55                  60                  


Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu Gly 
65                  70                  75                  80  


Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu Lys 
                85                  90                  95      


Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala Val 
            100                 105                 110         


Cys Glu Phe Pro Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Thr Asp Met Ser Arg Lys 
    130                 135                 140                 


Ala Phe Val Phe Pro Lys Glu Ser Asp Thr Ser Tyr Val Ser Leu Lys 
145                 150                 155                 160 


Ala Pro Leu Thr Lys Pro Leu Lys Ala Phe Thr Val Cys Leu His Phe 
                165                 170                 175     


Tyr Thr Glu Leu Ser Ser Thr Arg Gly Tyr Ser Ile Phe Ser Tyr Ala 
            180                 185                 190         


Thr Lys Arg Gln Asp Asn Glu Ile Leu Ile Phe Trp Ser Lys Asp Ile 
        195                 200                 205             


Gly Tyr Ser Phe Thr Val Gly Gly Ser Glu Ile Leu Phe Glu Val Pro 
    210                 215                 220                 


Glu Val Thr Val Ala Pro Val His Ile Cys Thr Ser Trp Glu Ser Ala 
225                 230                 235                 240 


Ser Gly Ile Val Glu Phe Trp Val Asp Gly Lys Pro Arg Val Arg Lys 
                245                 250                 255     


Ser Leu Lys Lys Gly Tyr Thr Val Gly Ala Glu Ala Ser Ile Ile Leu 
            260                 265                 270         


Gly Gln Glu Gln Asp Ser Phe Gly Gly Asn Phe Glu Gly Ser Gln Ser 
        275                 280                 285             


Leu Val Gly Asp Ile Gly Asn Val Asn Met Trp Asp Phe Val Leu Ser 
    290                 295                 300                 


Pro Asp Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser Pro Asn 
305                 310                 315                 320 


Val Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln Gly Glu Val Phe 
                325                 330                 335     


Thr Lys Pro Gln Leu Trp Pro 
            340             


<210> 37
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (263)..(282)
<223> Any amino acid and this region may encompass 0 to 20 residues,
      wherein some positions may be absent

<400> 37
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Ala Pro Asp Gly Asp Ser Ser Leu Ala Ala 
225                 230                 235                 240 


Ser Glu Arg Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp 
                245                 250                 255     


Leu Thr Phe Ser Leu Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Thr Asp Met Ser Arg 
        275                 280                 285             


Lys Ala Phe Val Phe Pro Lys Glu Ser Asp Thr Ser Tyr Val Ser Leu 
    290                 295                 300                 


Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala Phe Thr Val Ala Leu His 
305                 310                 315                 320 


Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly Tyr Ser Ile Phe Ser Tyr 
                325                 330                 335     


Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu Ile Phe Trp Ser Lys Asp 
            340                 345                 350         


Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser Glu Ile Leu Phe Glu Val 
        355                 360                 365             


Pro Glu Val Thr Val Ala Pro Val His Ile Ala Thr Ser Trp Glu Ser 
    370                 375                 380                 


Ala Ser Gly Ile Val Glu Phe Trp Val Asp Gly Lys Pro Arg Val Arg 
385                 390                 395                 400 


Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly Ala Glu Ala Ser Ile Ile 
                405                 410                 415     


Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly Asn Phe Glu Gly Ser Gln 
            420                 425                 430         


Ser Leu Val Gly Asp Ile Gly Asn Val Asn Met Trp Asp Phe Val Leu 
        435                 440                 445             


Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser Pro 
    450                 455                 460                 


Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln Gly Glu Val 
465                 470                 475                 480 


Phe Thr Lys Pro Gln Leu Trp Pro 
                485             


<210> 38
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Ala Lys Thr His His His His His His Gln Thr Asp Met Ser Arg Lys 
1               5                   10                  15      


Ala Phe Val Phe Pro Lys Glu Ser Asp Thr Ser Tyr Val Ser Leu Lys 
            20                  25                  30          


Ala Pro Leu Thr Lys Pro Leu Lys Ala Phe Thr Val Cys Leu His Phe 
        35                  40                  45              


Tyr Thr Glu Leu Ser Ser Thr Arg Gly Tyr Ser Ile Phe Ser Tyr Ala 
    50                  55                  60                  


Thr Lys Arg Gln Asp Asn Glu Ile Leu Ile Phe Trp Ser Lys Asp Ile 
65                  70                  75                  80  


Gly Tyr Ser Phe Thr Val Gly Gly Ser Glu Ile Leu Phe Glu Val Pro 
                85                  90                  95      


Glu Val Thr Val Ala Pro Val His Ile Cys Thr Ser Trp Glu Ser Ala 
            100                 105                 110         


Ser Gly Ile Val Glu Phe Trp Val Asp Gly Lys Pro Arg Val Arg Lys 
        115                 120                 125             


Ser Leu Lys Lys Gly Tyr Thr Val Gly Ala Glu Ala Ser Ile Ile Leu 
    130                 135                 140                 


Gly Gln Glu Gln Asp Ser Phe Gly Gly Asn Phe Glu Gly Ser Gln Ser 
145                 150                 155                 160 


Leu Val Gly Asp Ile Gly Asn Val Asn Met Trp Asp Phe Val Leu Ser 
                165                 170                 175     


Pro Asp Glu Ile Asn Thr Ile Tyr Leu Gly Gly Pro Phe Ser Pro Asn 
            180                 185                 190         


Val Leu Asn Trp Arg Ala Leu Lys Tyr Glu Val Gln Gly Glu Val Phe 
        195                 200                 205             


Thr Lys Pro Gln Leu Trp Pro 
    210                 215 


<210> 39
<211> 206
<212> PRT
<213> Homo sapiens

<400> 39
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
        195                 200                 205     


<210> 40
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (207)..(226)
<223> Any amino acid and this region may encompass 0 to 20 residues,
      wherein some positions may be absent

<400> 40
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        355                 360                 365             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala 
    450                 455             


<210> 41
<211> 439
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro Leu Glu 
        195                 200                 205             


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Ala 
        435                 


<210> 42
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asp Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Ala 
225                 230         


<210> 43
<211> 458
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (207)..(226)
<223> Any amino acid and this region may encompass 0 to 20 residues,
      wherein some positions may be absent

<400> 43
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        355                 360                 365             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala 
    450                 455             


<210> 44
<211> 438
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu Ser Asp 
1               5                   10                  15      


Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu Lys Ala 
            20                  25                  30          


Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr Arg Gly 
        35                  40                  45              


Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu Ile Leu 
    50                  55                  60                  


Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly Gly Ser 
65                  70                  75                  80  


Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val His Ile 
                85                  90                  95      


Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp Val Asp 
            100                 105                 110         


Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr Val Gly 
        115                 120                 125             


Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe Gly Gly 
    130                 135                 140                 


Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn Val Asn 
145                 150                 155                 160 


Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile Tyr Leu 
                165                 170                 175     


Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu Lys Tyr 
            180                 185                 190         


Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro Glu Pro 
        195                 200                 205             


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    210                 215                 220                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            260                 265                 270         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        275                 280                 285             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                325                 330                 335     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            340                 345                 350         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        355                 360                 365             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    370                 375                 380                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
385                 390                 395                 400 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                405                 410                 415     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly Ala 
        435             


<210> 45
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 45
cagaccgata tgagccggaa agccttcgtg ttccctaaag agagcgatac cagctatgtg       60

agcctgaaag ccccactgac caaaccactg aaggccttca ccgtgtgcct gcacttttac      120

accgagctga gctccacacg agggtacagc atcttttcct atgctacaaa gaggcaggac      180

aacgaaatcc tgattttctg gtcaaaagat atcggctata gctttactgt gggcggatcc      240

gagattctgt tcgaggtgcc cgaagtcaca gtggctcctg tccatatctg tacttcctgg      300

gagtcagcaa gcggcattgt cgaattctgg gtggacggaa agcctagggt gagaaaatct      360

ctgaagaaag gatacacagt gggggccgag gctagtatca ttctggggca ggaacaggac      420

tcattcgggg gcaactttga aggctcccag tctctggtcg gggatatcgg caacgtgaac      480

atgtgggact ttgtcctgag cccagatgag atcaatacca tctacctggg agggcccttc      540

agccctaacg tgctgaattg gcgcgcactg aagtatgagg tccagggcga agtgtttaca      600

aaaccccagc tgtggcca                                                    618


<210> 46
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 46
cagacagaca tgtcgaggaa ggcttttgtg tttcccaaag agtcggatac ttcctatgta       60

tccctcaaag cacccttaac gaagcctctc aaagccttca ctgtgtgcct ccacttctac      120

acggaactgt cctcgaccag agggtacagt attttctcgt atgctactaa gagacaagac      180

aatgagattc tcatattttg gtctaaggat ataggataca gttttacagt gggtgggtct      240

gaaatattat tcgaggttcc tgaagtcaca gtagctccag tacacatttg cacaagctgg      300

gagtccgcct cagggatcgt ggagttctgg gtagatggga agcccagggt gaggaagagt      360

ctgaagaagg gatacactgt gggggcagaa gcaagcatca tcttggggca ggagcaggat      420

tccttcggtg ggaactttga aggaagccag tccctggtgg gagacattgg aaatgtgaac      480

atgtgggact ttgtgctgtc accagatgag attaacacca tctatcttgg cgggcccttc      540

agtcctaatg tcctgaactg gcgggcactg aagtatgaag tgcaaggcga agtgttcacc      600

aaaccccagc tgtggccc                                                    618


<210> 47
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 47
cagacagaca tgagcaggaa ggcttttgtg tttcccaaag agagcgatac ttcctatgtg       60

tccctcaaag caccgctgac caagcctctc aaagccttca ctgtgtgcct ccacttctac      120

accgaactgt ccagcacccg tgggtacagt attttcagct atgctactaa gagacaggac      180

aatgagattc tcatattttg gtctaaggat atcggataca gttttacagt gggtgggtct      240

gaaatactgt tcgaggtgcc tgaagtcaca gtggctccag tacacatttg tacaagctgg      300

gagtccgcct cagggatcgt ggagttctgg gtggatggga agcccagggt gaggaagagt      360

ctgaagaagg gatacactgt gggggcagaa gcaagcatca tcctggggca ggagcaggat      420

tccttcggtg ggaactttga aggaagccag tccctggtgg gagacattgg aaatgtgaac      480

atgtgggact ttgtgctgtc accagatgag attaacacca tctatctggg cgggcccttc      540

agtcctaatg tcctgaactg gcgggcactg aagtatgaag tgcagggcga agtgttcacc      600

aaaccccagc tgtggccc                                                    618


<210> 48
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 48
cagacagaca tgtcgaggaa ggcttttgtg tttcccaaag agtcggatac ttcctatgta       60

tccctcaaag caccgttaac gaagcctctc aaagccttca ctgtgtgcct ccacttctac      120

acggaactgt cctcgacccg tgggtacagt attttctcgt atgctactaa gagacaagac      180

aatgagattc tcatattttg gtctaaggat ataggataca gttttacagt gggtgggtct      240

gaaatattat tcgaggttcc tgaagtcaca gtagctccag tacacatttg tacttcctgg      300

gagtcagcaa gcggcattgt cgaattctgg gtggacggaa agcctagggt gagaaaatct      360

ctgaagaaag gatacacagt gggggccgag gctagtatca ttctggggca ggaacaggac      420

tcattcgggg gcaactttga aggctcccag tctctggtcg gggatatcgg caacgtgaac      480

atgtgggact ttgtcctgag cccagatgag atcaatacca tctacctggg agggcccttc      540

agccctaacg tgctgaattg gcgcgcactg aagtatgagg tccagggcga agtgtttaca      600

aaaccccagc tgtggcca                                                    618


<210> 49
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 49
cagaccgata tgagccggaa agccttcgtg ttccctaaag agagcgatac cagctatgtg       60

agcctgaaag ccccactgac caaaccactg aaggccttca ccgtgtgcct gcacttttac      120

accgagctga gctccacacg agggtacagc atcttttcct atgctacaaa gaggcaggac      180

aacgaaatcc tgattttctg gtcaaaagat atcggctata gctttactgt gggcggatcc      240

gagattctgt tcgaggtgcc cgaagtcaca gtggctcctg tccatatctg tacaagctgg      300

gagtccgcct cagggatcgt ggagttctgg gtagatggga agcccagggt gaggaagagt      360

ctgaagaagg gatacactgt gggggcagaa gcaagcatca tcttggggca ggagcaggat      420

tccttcggtg ggaactttga aggaagccag tccctggtgg gagacattgg aaatgtgaac      480

atgtgggact ttgtgctgtc accagatgag attaacacca tctatcttgg cgggcccttc      540

agtcctaatg tcctgaactg gcgggcactg aagtatgaag tgcaaggcga agtgttcacc      600

aaaccccagc tgtggccc                                                    618


<210> 50
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 50
cagaccgata tgagccggaa agccttcgtg ttccctaaag agagcgatac cagctatgtg       60

agcctgaaag ccccactgac caaaccactg aaggccttca ccgtgtgcct gcacttttac      120

accgagctga gctccacacg agggtacagc atcttttcgt atgctactaa gagacaagac      180

aatgagattc tcatattttg gtctaaggat ataggataca gttttacagt gggtgggtct      240

gaaatattat tcgaggttcc tgaagtcaca gtagctccag tacacatttg tacaagctgg      300

gagtccgcct cagggatcgt ggagttctgg gtagatggga agcccagggt gaggaagagt      360

ctgaagaagg gatacactgt gggggcagaa gcaagcatca tcttggggca ggagcaggat      420

tccttcggtg ggaactttga aggaagccag tccctggtgg gagacattgg aaatgtgaac      480

atgtgggact ttgtgctgtc accagatgag atcaatacca tctacctggg agggcccttc      540

agccctaacg tgctgaattg gcgcgcactg aagtatgagg tccagggcga agtgtttaca      600

aaaccccagc tgtggcca                                                    618


<210> 51
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
cagacagaca tgtcgaggaa ggcttttgtg tttcccaaag agtcggatac ttcctatgta       60

tccctcaaag caccgttaac gaagcctctc aaagccttca ctgtgtgcct ccacttctac      120

acggaactgt cctcgacccg tgggtacagt attttctcct atgctacaaa gaggcaggac      180

aacgaaatcc tgattttctg gtcaaaagat atcggctata gctttactgt gggcggatcc      240

gagattctgt tcgaggtgcc cgaagtcaca gtggctcctg tccatatctg tacttcctgg      300

gagtcagcaa gcggcattgt cgaattctgg gtggacggaa agcctagggt gagaaaatct      360

ctgaagaaag gatacacagt gggggccgag gctagtatca ttctggggca ggaacaggac      420

tcattcgggg gcaactttga aggctcccag tctctggtcg gggatatcgg caacgtgaac      480

atgtgggact ttgtcctgag cccagatgag attaacacca tctatcttgg cgggcccttc      540

agtcctaatg tcctgaactg gcgggcactg aagtatgaag tgcaaggcga agtgttcacc      600

aaaccccagc tgtggccc                                                    618


<210> 52
<211> 618
<212> DNA
<213> Homo sapiens

<400> 52
cagacagaca tgtcgaggaa ggcttttgtg tttcccaaag agtcggatac ttcctatgta       60

tccctcaaag caccgttaac gaagcctctc aaagccttca ctgtgtgcct ccacttctac      120

acggaactgt cctcgacccg tgggtacagt attttctcgt atgctactaa gagacaagac      180

aatgagattc tcatattttg gtctaaggat ataggataca gttttacagt gggtgggtct      240

gaaatattat tcgaggttcc tgaagtcaca gtagctccag tacacatttg tacaagctgg      300

gagtccgcct cagggatcgt ggagttctgg gtagatggga agcccagggt gaggaagagt      360

ctgaagaagg gatacactgt gggggcagaa gcaagcatca tcttggggca ggagcaggat      420

tccttcggtg ggaactttga aggaagccag tccctggtgg gagacattgg aaatgtgaac      480

atgtgggact ttgtgctgtc accagatgag attaacacca tctatcttgg cgggcccttc      540

agtcctaatg tcctgaactg gcgggcactg aagtatgaag tgcaaggcga agtgttcacc      600

aaaccccagc tgtggccc                                                    618


<210> 53
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 53
His His His His His His 
1               5       


