                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Buck, Christopher B
       Ray, Upasana
       Pastrana, Diana V
 
<120>  IMMUNOGENIC JC POLYOMAVIRUS COMPOSITIONS AND METHODS OF USE

<130>  4239-91716-02

<150>  US 61/919,043
<151>  2013-12-20

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  JC virus

<400>  1

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  2
<211>  354
<212>  PRT
<213>  JC virus

<400>  2

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Ala Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Ile Glu Glu Val Arg Val Phe Glu Gly Thr Glu Gln Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  3
<211>  354
<212>  PRT
<213>  JC virus

<400>  3

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Phe Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Ala Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Ile Glu Glu Val Arg Val Phe Glu Gly Thr Glu Gln Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  4
<211>  354
<212>  PRT
<213>  JC virus

<400>  4

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Phe Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Ala Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Ser Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Ile Glu Glu Val Arg Val Phe Glu Gly Thr Glu Gln Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  5
<211>  354
<212>  PRT
<213>  JC virus

<400>  5

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Phe Gly Ser Gln His Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  6
<211>  354
<212>  PRT
<213>  JC virus

<400>  6

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Ala Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Phe Gly Ser Gln His Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Ile Glu Glu Val Arg Val Phe Glu Gly Thr Glu Gln Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  7
<211>  354
<212>  PRT
<213>  JC virus

<400>  7

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Phe Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  8
<211>  354
<212>  PRT
<213>  JC virus

<400>  8

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Phe Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Ala Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Lys Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Ile Glu Glu Val Arg Val Phe Glu Gly Thr Glu Gln Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  9
<211>  345
<212>  PRT
<213>  JC virus

<400>  9

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg 
            340                 345 


<210>  10
<211>  354
<212>  PRT
<213>  JC virus

<400>  10

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Leu Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Lys Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  11
<211>  354
<212>  PRT
<213>  JC virus

<400>  11

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Val 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Ser Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Ala 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Ser Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  12
<211>  354
<212>  PRT
<213>  JC virus

<400>  12

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Val Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Ala Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Ala Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Val Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Glu Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  13
<211>  354
<212>  PRT
<213>  JC virus

<400>  13

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  14
<211>  354
<212>  PRT
<213>  JC virus

<400>  14

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Leu Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Lys Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Ile Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  15
<211>  354
<212>  PRT
<213>  JC virus

<400>  15

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys His Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Thr Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  16
<211>  1065
<212>  DNA
<213>  JC virus

<400>  16
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgttttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatttcta tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctaatgtggg aggctgtgac cttaaaaact gaggttatag gggtaacaac tttgatgaat      360

gtgcactcta atggtcaagc aactcatgac aatggtgcag gaaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt ggtttttaac      480

tacagaacaa agtacccaga tggaacaatt tttccaaaga atgcaacagt gcaatctcaa      540

gtaatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgct gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttgtatt tgtcagctgt ggatgtttgt      780

ggcatgttta ctaacagatc tggttcccag cagtggagag gactgtccag atattttaag      840

gttcagctaa gaaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgat      900

ttaattaaca gaaggacccc tagagttgat gggcagccta tgtatggcat ggatgctcag      960

gtagaggagg ttagagtttt tgaggggaca gaggaacttc caggggaccc agacatgatg     1020

agatatgttg acagatatgg acagttgcaa acaaagatgc tgtaa                     1065


<210>  17
<211>  1065
<212>  DNA
<213>  JC virus

<400>  17
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatttcta tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atcttacctg tggaaatata      300

ctaatgtggg aggctgtaac cttaaaaact gaggtcatag gggtgacaac tttgatgaat      360

gtgcactcta atggtcaagc aactcatgac aatggtgcag caaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt ggtttttaat      480

tacagaacaa cgtacccaga tggaacaatt tttccaaaga atgcaacagt gcaatctcaa      540

gtaatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgct gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttgtatt tgtcagctgt tgatgtttgt      780

ggcatgttta ctaacagatc tggttcccag cagtggagag gactctccag atattttaag      840

gttcagctaa gaaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgac      900

ttaattaaca gaaggacccc tagagttgat gggcagccta tgtatggcat ggatgctcaa      960

atagaggagg ttagagtttt tgaggggaca gagcaacttc caggggaccc agatatgatg     1020

agatatgttg acagatatgg acagttgcag acaaaaatgc tgtaa                     1065


<210>  18
<211>  1034
<212>  DNA
<213>  JC virus

<400>  18
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatttcta tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atcttacctg tggaaatata      300

ctaatgtggg aggctgtgac cttaaaaact gaggtcatag gggtgacaac tttgatgaat      360

gtgcactcta atggtcaagc aactcatgac aatggtgcag caaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt ggtttttaat      480

tacagaacaa cgtacccaga tggaacaatt tttccaaaga atgcaacagt gcaatctcaa      540

gtaatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgct gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttgtatt tgtcagctgt tgatgtttgt      780

ggcatgttta ctaacagatc tggttcccag cagtggagag gactctccag atattttaag      840

gttcagctaa gaaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgat      900

ttaattaaca gaaggacccc tagagttgat gggcagccta tgtatggtat ggatgctcaa      960

atagaggagg ttagagtttt tgaggggaca gagcaacttc caggagaccc agatatgatg     1020

agatatgttg acag                                                       1034


<210>  19
<211>  1065
<212>  DNA
<213>  JC virus

<400>  19
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatatcta tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctcatgtggg aggctgtgac cttaaaaact gaggttatag gggtgacaag tttgatgaat      360

gtgcactcta atgggcaagc aactcatgac aatggtgcag ggaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt gctttttaat      480

tacagaacaa agtacccaga tggaacaatt tttccaaaga atgccacagt gcaatctcaa      540

gtcatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgtt gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttatact tgtcagctgt tgatgtctgt      780

ggcatgttta ctaacaggtc aggttcccag cagtggagag gactctccag atattttaag      840

gttcagctaa ggaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgat      900

ctaattaaca gaaggactcc tagagttgat gggcagccta tgtatggcat ggatgctcaa      960

gttgaggagg ttagagtttt tgagggaaca gaggagcttc caggggaccc agacatgatg     1020

agatatgttg acaaatatgg acagttgcag acaaaaatgc tgtaa                     1065


<210>  20
<211>  1065
<212>  DNA
<213>  JC virus

<400>  20
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatatctg tatcagatac atttgaaagt gactccccaa gtaaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctcatgtggg aggctgtgac cttaaaaact gaggttatag gggtgacaag tttgatgaat      360

gtgcactcta atggtcaagc agctcatgac aatggtgcag ggaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt ggtttttaat      480

tacagaacta agtacccaga tggaacaatt tttccaaaga atgccacagt gcaatctcaa      540

gtcatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaagtgttc ctccagttct tcatataaca aacactgcca caacagtgtt gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttatact tgtcagctgt tgatgtctgt      780

ggcatgttta ctaacaggtc tggttcccag cagtggagag gactctccag atattttaag      840

gttcagctaa ggaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgat      900

ttaattaaca gaaggactcc tagagttgat gggcagccta tgtatggcat ggatgctcaa      960

gtagaggagg ttagagtttt tgagggaaca gaggagcttc caggggaccc agacatgatg     1020

agatacgttg acagatatgg acagttgcag acaaaaatgc tgtaa                     1065


<210>  21
<211>  1065
<212>  DNA
<213>  JC virus

<400>  21
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tctatatcta tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagagttcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctcatgtggg aggctgtgac cttaaaaact gaggttatag gggtgacaac tttgatgaat      360

gtgcactcta atgggcaagc aactcatgac aatggtgcag caaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt ggcttttaat      480

tacagaacaa cgtacccaga tggaacaatt tttccaaaga atgccacagt gcaatctcaa      540

gtcatgaaca cagagcacaa ggcgtaccta gataagaaca aagtatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgtt gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttatatt tgtcagctgt tgatgtctgt      780

ggcatgttta ctaacaggtc tggttcccag cagtggagag gactctccag atattttaag      840

gttcagctaa ggaaaaggag ggttaaaaac ccctacccaa tttcttttct tcttactgat      900

ttaattaata gaaggactcc tagagttgat gggcagccta tgtatggcat ggatgctcaa      960

gtagaggagg ttagagtttt tgagggaaca gaggagcttc cagaggaccc agacatgatg     1020

agatacgttg acagatatgg acagttgcag acaaaaatgc tgtaa                     1065


<210>  22
<211>  1065
<212>  DNA
<213>  JC virus

<400>  22
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaactactt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc attttagagg ttttagtaag      180

tcaatttcta tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctaatgtggg aggctgtgac cctaaaaact gaggttatag gggtgacaac tttgatgaat      360

gtgcactcta atggtcaagc aactcatgac aatggtgcag ggaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacaaggggt ggtgttcaat      480

tacagaacaa cgtacccaga tggaacaatt tttccaaaga atgcaacagt gcagtctcaa      540

gtaatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgtgc ctccagttct tcatataaca aacactgcca caacagtgct gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttgtatt tgtcagctgt tgatgtttgt      780

ggcatgttta ctaacagatc tggttcccag cagtggagag gactctccag atattttaag      840

gttcagctaa ggaaaaggag ggttaaaaac ccctacccaa tttctttcct tctgactgat      900

ttaatcaaca gaaggactcc tagagttgat gggcagccta tgtatggcat ggatgctcaa      960

gtagaggagg ttagagtttt tgaggggaca gaggaacttc caggggaccc agacatgatg     1020

agatatgttg acagatatgg acagttgcag accaaaatgc tgtaa                     1065


<210>  23
<211>  1065
<212>  DNA
<213>  JC virus

<400>  23
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatttcta tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctaatgtggg aggctgtgac cttaaagact gaggttttag gggtgacaac tttgatgaat      360

gtgcactcta atggtcaagc aactcatgac aatggtgcag gaaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt ggtttttaat      480

tacagaacaa agtacccaga tggaacaatt tttccaaaga atgcaacagt gcaatctcaa      540

gtaatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgct gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttgtatt tgtcagctgt tgatgtttgt      780

ggcatgttta ctaacagatc tggttcccag cagtggagag gactgtccag atattttaag      840

gttcagctaa gaaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgat      900

ttaattaaca gaaggacccc taaagttgat gggcagccta tgtatggcat ggatgctcaa      960

atagaggagg ttagagtttt tgaggggaca gaggaactcc caggggaccc agacatgatg     1020

agatatgttg acagatatgg acagttgcag acaaaaatgc tgtaa                     1065


<210>  24
<211>  1065
<212>  DNA
<213>  JC virus

<400>  24
atggccccaa caaaaagaaa aggagaaagg aagcaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatttcca tatcagatac atttgaaagt gactccccaa ataaggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctgatgtggg aggctgtgac cctaaaaact gaggttatag gggtgacaac tttgatgaat      360

gtgcactcta atggtcaagc aactcatgac aatggtgcag gaaagccagt gcagggcacc      420

agctttcatt ttttttctgt cgggggggag gctttagaat tacagggggt ggtttttaat      480

tacagaacaa cgtacccaga cggaacaatt tttccaaaga atgcaacagt gcaatctcaa      540

gtaatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgct gctggatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttgtatt tgtcagctgt tgatgtttgt      780

ggcatgttta ctaacagatc tggttcccag cagtggagag gactgtccag atattttaag      840

gttcagctaa gaaaaaggag ggttaaaaac ccctacccaa tttcttttct tcttactgat      900

ttaattaaca gaaggacccc tagagttgat gggcagccta tgtatggcat ggatgctcag      960

gtagaggagg ttagagtttt tgaggggaca gaggaacttc caggggaccc agacatgatg     1020

agatatgttg acagatatgg acagttgcag acaaagatgc tgtaa                     1065


<210>  25
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized JCV genotype 2A VP1 coding sequence

<400>  25
atggcaccca caaagcgcaa gggcgaacgc aaggacccag tccaggtccc caagttgctg       60

atcaggggcg gcgtggaggt cctggaggtc aagaccggcg tggactccat caccgaggtg      120

gagtgtttct tgacacccga gatgggcgac cccgacgagc acctgcgcgg gttcagcaag      180

agcatcagca tcagcgacac attcgagtcc gactcaccca ataaggacat gttgccatgc      240

tattccgtcg cccgcatccc actgcccaac ctcaacgaag acttgacatg cggcaacatc      300

ctgatgtggg aagccgtcac actgaagacc gaagtcatcg gcgtcaccac cctgatgaat      360

gtgcactcca acggccaagc gacgcacgac aacggcgccg ggaagccagt ccaggggaca      420

agcttccatt tcttcagcgt cggcggcgag gcactcgagc tgcaaggcgt ggtgttcaac      480

tatcgcacca agtatcccga cggcaccata ttccccaaga acgcaaccgt ccaaagtcag      540

gtcatgaaca ccgagcacaa agcatatctc gataagaata aggcctaccc cgtcgagtgt      600

tgggtccccg atccaaccag gaacgagaac acccgctact tcggcaccct gaccggcggc      660

gagaacgtcc cacccgtgtt gcacatcaca aataccgcca caaccgtcct gctcgacgag      720

ttcggcgtcg gcccactctg caagggagac aacctctacc tgagcgccgt cgacgtctgc      780

ggaatgttca ccaatcgaag cggcagccag caatggcgcg ggttgtcccg ctacttcaaa      840

gtccagctcc gcaagcgccg cgtgaagaat ccctatccaa tcagtttcct gctgaccgat      900

ttgatcaatc gccgcacacc acgcgtcgac ggccagccca tgtacggcat ggacgcccaa      960

gtcgaagaag tgcgcgtatt cgaggggacc gaggagttgc ccggcgatcc cgacatgatg     1020

cgctacgtcg atcgctacgg ccagctccaa accaagatgc tatga                     1065


<210>  26
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized JCV genotype 3B VP1 coding sequence

<400>  26
atggcaccca caaagcgcaa gggcgaacgc aaggacccag tccaggtccc caagttgctg       60

atcaggggcg gcgtggaggt cctggaggtc aagaccggcg tggactccat caccgaggtg      120

gagtgtttct tgacacccga gatgggcgac cccgacgagc acttgcgcgg gttttcgaag      180

agcatcagca tcagcgacac attcgagtcc gactcaccca ataaggacat gttgccatgc      240

tattccgtcg cccgcatccc actgcccaac ctcaacgaag acttgacatg cggcaacatc      300

ctgatgtggg aagccgtcac actgaagacc gaagtcatcg gcgtcaccac cctgatgaat      360

gtgcactcca acggccaagc gacgcacgac aacggcgccg cgaagccagt ccaggggaca      420

agcttccatt tcttcagcgt cggcggcgag gcactcgagc tgcaaggcgt ggtgttcaac      480

tatcgcacca cgtatcccga cggcaccata ttccccaaga acgcaaccgt ccaaagtcag      540

gtcatgaaca ccgagcacaa agcatatctc gataagaata aggcctaccc cgtcgagtgt      600

tgggtccccg atccaaccag gaacgagaac acccgctact tcggcaccct gaccggcggc      660

gagaacgtcc cacccgtgtt gcacatcaca aataccgcca caaccgtcct gctcgacgag      720

ttcggcgtcg gcccactctg caagggagac aacctctacc tgagcgccgt cgacgtctgc      780

ggaatgttca ccaatcgaag cggcagccag caatggcgcg ggttgtcccg ctacttcaaa      840

gtccagctcc gcaagcgccg cgtgaagaat ccctatccaa tcagtttcct gctgaccgat      900

ttgatcaatc gccgcacacc acgcgtcgac ggccagccca tgtacggcat ggacgcccaa      960

atcgaagaag tgcgcgtatt cgaggggacc gagcagttgc ccggcgatcc cgacatgatg     1020

cgctacgtcg atcgctacgg ccagctccaa accaagatgc tatga                     1065


<210>  27
<211>  354
<212>  PRT
<213>  JC virus

<400>  27

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Arg Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Leu Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Lys Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


