                         SEQUENCE LISTING

<110>  Tufts University
       Shoemaker, Charles  B.
 
<120>  Methods, compositions and kits for treating a subject using a 
       recombinant neutralizing binding protein

<130>  34724-147

<150>  61/920,825
<151>  2013-12-26

<160>  173    

<170>  PatentIn version 3.5

<210>  1
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv#2 single chain antibody


<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is a, c, g, or t

<400>  1
caggctgtgc tgactcagcc gtcctccgtg tccgggtccc cgggccnnan ggtctccatc       60

acctgctctg gaagcaggag taacgttggc acatatggtg taggttggtt ccaacagctc      120

ccaggatcgg gcctcagaac catcatctat tataatgaca aacgaccctc aggggtcccc      180

gaccgattct ctgcctccaa atcgggcaac acagccaccc tgatcatcag ctcgctccag      240

gctgaggatg aggccgatta tttctgtgga agtgccgacg gtagtagtta tggtattttc      300

ggcagtggga ccagactgac cgtcctgggt cagcccgcgg ccgctggtgg aggcggttca      360

ggcggaggtg gctctggcgg tggcggatcg gcgcgccagg tggggctgca ggagtcggga      420

cccagcctgg tgaagccctc acagaccctc tccctcacct gcacggtctc tggattctca      480

ttgtccaaca gtgttgtagg ctgggtccgc caggctccag gaaaggtgcc ggagtggctt      540

ggtagtatag acagtggtgg ttacacagtc gctgacccgg ccctgaaatc ccgactcagc      600

atcacaaggg acacttccaa gagccaagtc tccctgtcac tgaacagcgt gacaactgag      660

gacacggccg tgtactactg tacaagggct tatagtatta cttattatgc gtatcccccc      720

tatatcgact actggggccc aggactcctg gtcaccgtct cctcaactag tggtgcgccg      780

gtgccgtatc cggatccgct ggaaccgcgt gccgca                                816


<210>  2
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#2 single chain antibody


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ser Pro Gly Xaa 
1               5                   10                  15      


Xaa Val Ser Ile Thr Cys Ser Gly Ser Arg Ser Asn Val Gly Thr Tyr 
            20                  25                  30          


Gly Val Gly Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Ile 
        35                  40                  45              


Ile Tyr Tyr Asn Asp Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Asn Thr Ala Thr Leu Ile Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gly Ser Ala Asp Gly Ser Ser 
                85                  90                  95      


Tyr Gly Ile Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ala Arg Gln Val Gly Leu Gln Glu Ser Gly Pro Ser Leu Val 
    130                 135                 140                 


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Ser Asn Ser Val Val Gly Trp Val Arg Gln Ala Pro Gly Lys Val 
                165                 170                 175     


Pro Glu Trp Leu Gly Ser Ile Asp Ser Gly Gly Tyr Thr Val Ala Asp 
            180                 185                 190         


Pro Ala Leu Lys Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser 
        195                 200                 205             


Gln Val Ser Leu Ser Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Arg Ala Tyr Ser Ile Thr Tyr Tyr Ala Tyr Pro Pro 
225                 230                 235                 240 


Tyr Ile Asp Tyr Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Thr 
                245                 250                 255     


Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Ala Ala 
            260                 265                 270         


<210>  3
<211>  826
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv#3 Single Chain Antibody

<400>  3
caggctgtgc tgactcagcc gtcctccgtg tccaggtccc tgggccagag tgtctccatc       60

acctgctctg gaagcagcag caacgttgga tatggtgatt atgtgggctg gttccaacgg      120

gtcccaggat cagcccccaa actcctcatc tatggtgcaa ccactcgagc ctcgggggtc      180

cccgaccgat tctccggctc caggtctggc aacacagcga ctctgaccat cagctcgctc      240

caggctgagg acgaggccga ttattactgt tcatcttacg acagtagtca ctatagtatt      300

ttcggcagtg ggaccagcct gaccgtcctg ggtcagcccg cggccgctgg tggaggcggt      360

tcaggcggag gtggctctgg cggtggcgga tcggcgcgcc aggtggagct gcaggagtcg      420

ggacccagcc tggtgaagcc ctcacagacc ctctccctca cctgcacggt ctctggattc      480

tcattaagta gcaatgctgt aggctgggtc cgccaggctc caggaaaggc gccggagtgg      540

gttggtggta tagatataga tggaaggccg gtctataaac caggccttaa gtcccggctc      600

agcatcacca gggacacctc caacgctcaa gtctccctgt cactgagcag cgtgacaact      660

gaggacacgg ccgtgtactt ctgtgcaagt tattatggtg gttatcttta taattatgcc      720

cctggggcat atatcgagca cttgagccca ggactcctga tcaccgtctc ctcaactagt      780

ggtgcgccgg tgccgtatcc ggatccgctg gaaaccgcgt gccgca                     826


<210>  4
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#3 single chain antibody

<400>  4

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Arg Ser Leu Gly Gln 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Tyr Gly 
            20                  25                  30          


Asp Tyr Val Gly Trp Phe Gln Arg Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Thr Thr Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Ser Ser 
                85                  90                  95      


His Tyr Ser Ile Phe Gly Ser Gly Thr Ser Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ala Arg Gln Val Glu Leu Gln Glu Ser Gly Pro Ser Leu 
    130                 135                 140                 


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe 
145                 150                 155                 160 


Ser Leu Ser Ser Asn Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Ala Pro Glu Trp Val Gly Gly Ile Asp Ile Asp Gly Arg Pro Val Tyr 
            180                 185                 190         


Lys Pro Gly Leu Lys Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Asn 
        195                 200                 205             


Ala Gln Val Ser Leu Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Phe Cys Ala Ser Tyr Tyr Gly Gly Tyr Leu Tyr Asn Tyr Ala 
225                 230                 235                 240 


Pro Gly Ala Tyr Ile Glu His Leu Ser Pro Gly Leu Leu Ile Thr Val 
                245                 250                 255     


Ser Ser Thr Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro 
            260                 265                 270         


Arg Ala Ala 
        275 


<210>  5
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv#7 Single Chain Antibody

<400>  5
tcctatgaac tgacccagcc gccttcaatg tcggtggcct tgggacagac ggccaaggtc       60

acctgccagg gagacaactt agaaaacttt tatgttcagt ggcaccagca gaagccgggc      120

caggcccctg tgacggtcat ttttcaggat aataagaggc cctcggggat ccctgaccgg      180

ttctctggct ccaactcggg gaacacggcc accctgacca tcagcggggc ccggaccgag      240

gacgaggccg actattactg tcagtcaggc cacagcagta tcggtggtgt tttcggcagc      300

gggaccagcc tgaccgtcct gggtcagccc gcggccgctg gtggaggcgg ttcaggcgga      360

ggtggctctg gcggtggcgg atcggcgcgc caggtgcagc tgcaggagtc gggacccagc      420

ctggtgaagc cctcacagac cctctccctc acctgcacgg tctctggctt ctcattaacg      480

ggaaattctg taacctgggt ccgccaggct ccaggaaacg tgccggagtg gcttggtggt      540

ataagccgcg gtggacgcac atactatgat acggccctga agtcccggct cagcatcacc      600

agggacacct ccaagaggca agtctcccta tcactgagca gcgtgacgac tgaggacacg      660

gccatgtact tctgtgcaag atcggcatat agtactcttt atgattatga gtatgccgct      720

gatatctacg actggggccc aggactcctg gtcaccgtct cctcaactag tggtgcgccg      780

gtgccgtatc cggatccgct ggaaccgcgt gccgca                                816


<210>  6
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#7 Single Chain Antibody

<400>  6

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Met Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Lys Val Thr Cys Gln Gly Asp Asn Leu Glu Asn Phe Tyr Val 
            20                  25                  30          


Gln Trp His Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val Ile Phe 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Ala Arg Thr Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Gly His Ser Ser Ile Gly Gly 
                85                  90                  95      


Val Phe Gly Ser Gly Thr Ser Leu Thr Val Leu Gly Gln Pro Ala Ala 
            100                 105                 110         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Ala Arg Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
    130                 135                 140                 


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
145                 150                 155                 160 


Gly Asn Ser Val Thr Trp Val Arg Gln Ala Pro Gly Asn Val Pro Glu 
                165                 170                 175     


Trp Leu Gly Gly Ile Ser Arg Gly Gly Arg Thr Tyr Tyr Asp Thr Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Arg Gln Val 
        195                 200                 205             


Ser Leu Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Met Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Ser Ala Tyr Ser Thr Leu Tyr Asp Tyr Glu Tyr Ala Ala 
225                 230                 235                 240 


Asp Ile Tyr Asp Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Thr 
                245                 250                 255     


Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Ala Ala 
            260                 265                 270         


<210>  7
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv#8 Single Chain Antibody


<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is a, c, g, or t

<400>  7
tcctatgaac tgacccagcc gccttcagtg tcggtggttt ggggncngan ggccgagatc       60

acctgccagg gagacctact ggataaaaaa tatacagctt ggtaccagca gaagccgggc      120

caggctccta tgaaaatcat taataaagac agtgagcggc cttcagggat ccgggaccgg      180

ttctcgggct ccagctcagg caaaacagcc accctaacca tcaacggggc ccggcctgag      240

gacgaggccg actattactg tttatcaggt gacagcaata ataatggtgt cttcggcagc      300

gggaccagcc tgaccgtcct gggtcagccc gcggccgctg gtggaggcgg ttcaggcgga      360

ggtggctctg gcggtggcgg atcggcgcgc caggtggagc tgcaggggtc gggacccagc      420

ctggtgaagc cctcgcagac cctctccctc acctgcacgg tctctggatt ctcatggccc      480

aacaatgctg tggattgggt ccgccaggct ccaggaaagg cgccggagtg gcttggtggt      540

attgccgata atggaagaac aaactacaac acggccctaa aagcccggct cagcatcact      600

agggacaccg ccaagagcca tgtctcccta tcgctgagca gcgtgacagc tgaggatacg      660

gccgtttact attgtacagc gggggttatg gtcatgcacg ccactgacta ctggggcccg      720

ggactcctgg tcaccgtctc ctcaactagt ggtgcgccgg tgccgtatcc ggatccgctg      780

gaaccgcgtg ccgca                                                       795


<210>  8
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#8 Single Chain Antibody


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Val Trp Gly Xaa 
1               5                   10                  15      


Xaa Ala Glu Ile Thr Cys Gln Gly Asp Leu Leu Asp Lys Lys Tyr Thr 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Met Lys Ile Ile Asn 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Arg Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Lys Thr Ala Thr Leu Thr Ile Asn Gly Ala Arg Pro Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Gly Asp Ser Asn Asn Asn Gly 
                85                  90                  95      


Val Phe Gly Ser Gly Thr Ser Leu Thr Val Leu Gly Gln Pro Ala Ala 
            100                 105                 110         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Ala Arg Gln Val Glu Leu Gln Gly Ser Gly Pro Ser Leu Val Lys Pro 
    130                 135                 140                 


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Trp Pro 
145                 150                 155                 160 


Asn Asn Ala Val Asp Trp Val Arg Gln Ala Pro Gly Lys Ala Pro Glu 
                165                 170                 175     


Trp Leu Gly Gly Ile Ala Asp Asn Gly Arg Thr Asn Tyr Asn Thr Ala 
            180                 185                 190         


Leu Lys Ala Arg Leu Ser Ile Thr Arg Asp Thr Ala Lys Ser His Val 
        195                 200                 205             


Ser Leu Ser Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Thr Ala Gly Val Met Val Met His Ala Thr Asp Tyr Trp Gly Pro 
225                 230                 235                 240 


Gly Leu Leu Val Thr Val Ser Ser Thr Ser Gly Ala Pro Val Pro Tyr 
                245                 250                 255     


Pro Asp Pro Leu Glu Pro Arg Ala Ala 
            260                 265 


<210>  9
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv#21 Single Chain Antibody


<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is a, c, g, or t

<400>  9
caggctgtgg tgactcagcc gtcctccgtg tccgggtccc cgggccnnan agtctccatc       60

acctgctctg gaagcagcag caacgttggt agatatgctg taggctggtt ccaacagctc      120

ccaggatcgg gcctcagaac cgtcatctat tataatagca atcgaccctc aggggtcccc      180

gaccgattct ctggctccaa atcgggcaac acagccaccc tgaccatcag ctcgctccag      240

gctgaggatg aggccgatta tttctgtgga agttatgaca gtagtatcta tggtgttttc      300

ggcagcggga ccaggctgac cgtcctgggt cagcccgcgg ccgctggtgg aggcggttca      360

ggcggaggtg gctctggcgg tggcggatcg gcgcgccagg tgcagctgca ggagtcggga      420

cccagcctgg tgaggccctc acagaccctc tccctcacct gcacgatctc tggattctct      480

ttaagagagt atggtgtagg ttgggtccgc caggctccag gaaaggcgtt ggagtggctt      540

gggcgaatag atgattctgg atacacatta cataatcctg cccttaagtc ccggctcacc      600

ataactaggg acatctccaa gagccaagtc tccctgtcac tgagcagcgt gacacttgag      660

gacacggccg aatattactg cgtatatgct agtcgtggta ctgcttggtt gggagacatc      720

gatgtctggg gcccaggact cctgctcact gtctcctcaa ctagtggtgc gccggtgccg      780

tatccggatc cgctggaacc gcgtgccgca                                       810


<210>  10
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#21 Single Chain Antibody


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Gln Ala Val Val Thr Gln Pro Ser Ser Val Ser Gly Ser Pro Gly Xaa 
1               5                   10                  15      


Xaa Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Arg Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Gln Gln Leu Pro Gly Ser Gly Leu Arg Thr Val 
        35                  40                  45              


Ile Tyr Tyr Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gly Ser Tyr Asp Ser Ser Ile 
                85                  90                  95      


Tyr Gly Val Phe Gly Ser Gly Thr Arg Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ala Arg Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val 
    130                 135                 140                 


Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Arg Glu Tyr Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala 
                165                 170                 175     


Leu Glu Trp Leu Gly Arg Ile Asp Asp Ser Gly Tyr Thr Leu His Asn 
            180                 185                 190         


Pro Ala Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Ile Ser Lys Ser 
        195                 200                 205             


Gln Val Ser Leu Ser Leu Ser Ser Val Thr Leu Glu Asp Thr Ala Glu 
    210                 215                 220                 


Tyr Tyr Cys Val Tyr Ala Ser Arg Gly Thr Ala Trp Leu Gly Asp Ile 
225                 230                 235                 240 


Asp Val Trp Gly Pro Gly Leu Leu Leu Thr Val Ser Ser Thr Ser Gly 
                245                 250                 255     


Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Ala Ala 
            260                 265                 270 


<210>  11
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv#E Single Chain Antibody


<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  n is a, c, g, or t

<400>  11
caggctgtgc tgactcagcc gtcctccgtg tccaggtccc tgggccnnan tgtctcgatc       60

acctgctctg gaggcagcag caacgttgga caaggtgatt atgtggcctg gttccaacag      120

gtcccaggat cagcccccaa actcctcatc tatgatgcga cgaatcgagc ctcgggggtc      180

cccgaccgat tcgtcggctc cagatatggc aactcagcga ctctgatcat cacctcggtc      240

caggctgagg acgaggccga ttattattgt gcatcttatg acagtagtat gtatacgatt      300

ttcggcagcg ggaccagcct gaccgtcctg ggtcagcccg cggccgctgg tggaggcggt      360

tcaggcggag gtggctctgg cggtggcgga tcggcgcgcc aggtggagct gcaggggtcg      420

ggacccagcc aggtgaagcc ctcacagacc ctctccctca tctgcacgat ctctggattc      480

tcattaacca gcaataatgt agcctgggtc cgccaggctc caggaaaggg actggagtgg      540

gttggtgtca taagtgatgg tggaactcca tactataact cggccctgaa atcccggctc      600

agcatcacca gggacacctc caagagccag gtctccctgt cactgagcag cgtgacaact      660

gaggacacgg ccgtgtacta ctgtgcacgg acgttggatt atagtcatat ttggttgtac      720

tccgccgacc aatggggccc aggactcctg gtcaccgtct cctcaactag tggtgcgccg      780

gtgccgtatc cggatccgct ggaaccgcgt gccgca                                816


<210>  12
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#E Single Chain Antibody


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Arg Ser Leu Gly Xaa 
1               5                   10                  15      


Xaa Val Ser Ile Thr Cys Ser Gly Gly Ser Ser Asn Val Gly Gln Gly 
            20                  25                  30          


Asp Tyr Val Ala Trp Phe Gln Gln Val Pro Gly Ser Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Thr Asn Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Val Gly Ser Arg Tyr Gly Asn Ser Ala Thr Leu Ile Ile Thr Ser Val 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Asp Ser Ser 
                85                  90                  95      


Met Tyr Thr Ile Phe Gly Ser Gly Thr Ser Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ala Arg Gln Val Glu Leu Gln Gly Ser Gly Pro Ser Gln 
    130                 135                 140                 


Val Lys Pro Ser Gln Thr Leu Ser Leu Ile Cys Thr Ile Ser Gly Phe 
145                 150                 155                 160 


Ser Leu Thr Ser Asn Asn Val Ala Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Gly Val Ile Ser Asp Gly Gly Thr Pro Tyr Tyr 
            180                 185                 190         


Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys 
        195                 200                 205             


Ser Gln Val Ser Leu Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Thr Leu Asp Tyr Ser His Ile Trp Leu Tyr 
225                 230                 235                 240 


Ser Ala Asp Gln Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Thr 
                245                 250                 255     


Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Ala Ala 
            260                 265                 270         


<210>  13
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv#7-2E Single Chain Antibody

<400>  13
ggtgcgccgg tgccgtatcc ggatccgctc gagccgcgtg ccggctccta tgaactgacc       60

cagccgcctt caatgtcggt ggccttggga cagacggcca aggtcacctg ccagggagac      120

aacttagaaa acttttatgt tcagtggcac cagcagaagc cgggccaggc ccctgtgacg      180

gtcatttttc aggataataa gaggccctcg gggatccctg accggttctc tggctccaac      240

tcggggaaca cggccaccct gaccatcagc ggggcccgga ccgaggacga ggccgactat      300

tactgtcagt caggccacag cagtatcggt ggtgttttcg gcagcgggac cagcctgacc      360

gtcctgggtc agcccgcggc cgctggtgga ggcggttcag gcggaggtgg ctctggcggt      420

ggcggatcgg cgcgccaggt gcagctgcag gagtcgggac ccagcctggt gaagccctca      480

cagaccctct ccctcacctg cacggtctct ggcttctcat taacgggaaa ttctgtaacc      540

tgggtccgcc aggctccagg aaacgtgccg gagtggcttg gtggtataag ccgcggtgga      600

cgcacatact atgatacggc cctgaagtcc cggctcagca tcaccaggga cacctccaag      660

aggcaagtct ccctatcact gagcagcgtg acgactgagg acacggccat gtacttctgt      720

gcaagatcgg catatagtac tctttatgat tatgagtatg ccgctgatat ctacgactgg      780

ggcccaggac tcctggtcac cgtctcctca actagtggtg cgccggtgcc gtatccggat      840

ccgctggaac cgcgtgccgc a                                                861


<210>  14
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#7-2E Single Chain Antibody

<400>  14

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Ala Gly Ser 
1               5                   10                  15      


Tyr Glu Leu Thr Gln Pro Pro Ser Met Ser Val Ala Leu Gly Gln Thr 
            20                  25                  30          


Ala Lys Val Thr Cys Gln Gly Asp Asn Leu Glu Asn Phe Tyr Val Gln 
        35                  40                  45              


Trp His Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val Ile Phe Gln 
    50                  55                  60                  


Asp Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Asn 
65                  70                  75                  80  


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Ala Arg Thr Glu Asp 
                85                  90                  95      


Glu Ala Asp Tyr Tyr Cys Gln Ser Gly His Ser Ser Ile Gly Gly Val 
            100                 105                 110         


Phe Gly Ser Gly Thr Ser Leu Thr Val Leu Gly Gln Pro Ala Ala Ala 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
    130                 135                 140                 


Arg Gln Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser 
145                 150                 155                 160 


Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly 
                165                 170                 175     


Asn Ser Val Thr Trp Val Arg Gln Ala Pro Gly Asn Val Pro Glu Trp 
            180                 185                 190         


Leu Gly Gly Ile Ser Arg Gly Gly Arg Thr Tyr Tyr Asp Thr Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Arg Gln Val Ser 
    210                 215                 220                 


Leu Ser Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Met Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Ser Ala Tyr Ser Thr Leu Tyr Asp Tyr Glu Tyr Ala Ala Asp 
                245                 250                 255     


Ile Tyr Asp Trp Gly Pro Gly Leu Leu Val Thr Val Ser Ser Thr Ser 
            260                 265                 270         


Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Ala Ala 
        275                 280                 285         


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope Tag

<400>  15

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly 
1               5                   


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents

<400>  17

Ala His His Ser Glu Asp Pro Ser 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents

<400>  18

Glu Pro Lys Thr Pro Lys Pro Gln 
1               5               


<210>  19
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  19
caggtgcagc tcgtggagtc aggaggaggc ttggtgcagc ctgggggatc tctgagactc       60

tcgtgtgtag tctctggaag tgacttcaat acctatatca tgggctggta ccgccaggtt      120

ccagggaagc cgcgcgagtt ggtcgcagat attactactg aaggaaaaac aaactatggc      180

ggctccgtaa agggacgatt caccatctcc agagacaacg ccaaaaacac ggtgtatctg      240

caaatgttcg gcctgaaacc tgaggacgcg ggtaattatg tctgtaacgc agactggaag      300

atgggtgcat ggaccgcggg ggactacggt atcgactact ggggcaaagg gaccctggtc      360

accgtctcct cagaacccaa gacaccaaaa ccacaa                                396


<210>  20
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Asp Phe Asn Thr Tyr 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Val Pro Gly Lys Pro Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Thr Thr Glu Gly Lys Thr Asn Tyr Gly Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Phe Gly Leu Lys Pro Glu Asp Ala Gly Asn Tyr Val Cys Asn 
                85                  90                  95      


Ala Asp Trp Lys Met Gly Ala Trp Thr Ala Gly Asp Tyr Gly Ile Asp 
            100                 105                 110         


Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Thr 
        115                 120                 125             


Pro Lys Pro Gln 
    130         


<210>  21
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  21
caggtgcagc tcgtggagtc cggtggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctgcagg caatctggat tattatgcca taggctggtt ccgccaggcc      120

ccagggaagg agcgcgaggg ggtctcatgt attagtagta gtgatggtag cactgtctat      180

acagactccg tgaagggccg attcaccatc tccagagaca ataccaagaa cacggtagat      240

ctgcaaatgg acaatttgaa acctgaggac acggccgttt attactgtgc gacagtcgtt      300

aactactact gcacagccgg tgggtccatt cacgcgagcc cgtatgaaat ctggggccag      360

gggacccagg tcaccgtctc ctcagcgcac cacagcgaag acccctcg                   408


<210>  22
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Gly Asn Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Val Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Val Val Asn Tyr Tyr Cys Thr Ala Gly Gly Ser Ile His Ala 
            100                 105                 110         


Ser Pro Tyr Glu Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Ala His His Ser Glu Asp Pro Ser 
    130                 135     


<210>  23
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  23
caggtgcagc tcgtggagtc cggcggaggc ttggtgcacc ctggggggtc tctgagactc       60

tcttgtgcac cctctgccag tctaccatca acacccttca accccttcaa caatatggtg      120

ggctggtacc gtcaggctcc aggtaaacag cgcgaaatgg tcgcaagtat tggtctacga      180

ataaactatg cagactccgt gaagggccga ttcaccatct ccagagacaa cgccaagaac      240

acggtggatc tgcagatgga cagcctgcga cctgaggact cagccacata ctactgtcat      300

atagaataca cccactactg gggcaaaggg accctggtca ccgtctcctc ggaacccaag      360

acaccaaaac cacaa                                                       375


<210>  24
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Pro Ser Ala Ser Leu Pro Ser Thr Pro 
            20                  25                  30          


Phe Asn Pro Phe Asn Asn Met Val Gly Trp Tyr Arg Gln Ala Pro Gly 
        35                  40                  45              


Lys Gln Arg Glu Met Val Ala Ser Ile Gly Leu Arg Ile Asn Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Asp Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Ser Ala Thr 
                85                  90                  95      


Tyr Tyr Cys His Ile Glu Tyr Thr His Tyr Trp Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Glu Pro Lys 
        115                 120                 125             


Thr Pro Lys Pro Gln 
    130             


<210>  25
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  25
caggtgcagc tcgtggagtc tggtggaggc ttggcgcagc ctggggggtc tctgagactc       60

tcctgtgaag cgtctggttt tgggacatgg ttcaggttcg atgagaacac cgtgaactgg      120

taccgccagc ctccaggaaa gtcgcgcgag ttcgacgagt tggtcgctcg ttacccaaaa      180

agtggcatcg taacctattt agactccgtg aagggccgat tcacgatctc cagagacaac      240

gccaaaaaaa tggcgtttct gcaaatggac aacctgaaac ctgaggacac ggccgtctat      300

tattgcaatg tcggtgaatt ttggggccag gggacccagg tcacgatctc ctcagaaccc      360

aagacaccaa aaccacaa                                                    378


<210>  26
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Gly Thr Trp Phe Arg 
            20                  25                  30          


Phe Asp Glu Asn Thr Val Asn Trp Tyr Arg Gln Pro Pro Gly Lys Ser 
        35                  40                  45              


Arg Glu Phe Asp Glu Leu Val Ala Arg Tyr Pro Lys Ser Gly Ile Val 
    50                  55                  60                  


Thr Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
65                  70                  75                  80  


Ala Lys Lys Met Ala Phe Leu Gln Met Asp Asn Leu Lys Pro Glu Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Asn Val Gly Glu Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Ile Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125     


<210>  27
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  27
caggtgcagc tcgtggagtc ggggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccctaggg tcgcgttaca tgagctgggt ccgccaggct      120

ccaggagagg ggttcgagtg ggtctcaagt attgaaccct ctggtaccgc atgggatgga      180

gactccgcga agggacgatt caccacttcc agagacgacg ccaagaacac gctttatctg      240

caaatgagca acctgcaacc cgaggacacg ggtgtttatt actgtgcaac agggtatcgg      300

acggacacga ggattccggg tggctcgtgg ggccagggga cccaggtcac cgtctcctca      360

gaacccaaga caccaaaacc acaa                                             384


<210>  28
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Gly Ser Arg 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Glu Pro Ser Gly Thr Ala Trp Asp Gly Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asp Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Asn Leu Gln Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Gly Tyr Arg Thr Asp Thr Arg Ile Pro Gly Gly Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125             


<210>  29
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  29
caggtgcagc tcgtggagtc tggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtcaag tctctggatt caccttcggt gactgggtca tgagctggtt ccgccaggct      120

ccggggaagg agcgcgaatt cgtcgcaagt attacggcta ctagtagtct aaagtattat      180

gcagactccg tgaagggccg attcaccatc tccagagaca atgtcaacaa cacactgttt      240

ctgcaaatgg atcgcctgaa atctgaggac acggccgttt attactgtcg gtcccccaac      300

tactggggcc aggggaccca ggtcaccgtc tccgccgaac ccaagacacc aaaaccacaa      360


<210>  30
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Val Ser Gly Phe Thr Phe Gly Asp Trp 
            20                  25                  30          


Val Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Ala Thr Ser Ser Leu Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Asn Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Arg Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Arg Ser Pro Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala 
            100                 105                 110         


Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120 


<210>  31
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  31
caggtgcagc tcgtggagtc aggtggaggc ttggtgcagg ttggggggtc tctgagactc       60

tcctgtgtag tttctggaag cgacatcagt ggcattgcga tgggctggta ccgccaggct      120

ccagggaagc ggcgcgaaat ggtcgcagat attttttctg gcggtagtac agactatgca      180

ggctccgtga agggccgatt caccatctcc agagacaacg ccaagaagac gagctatctg      240

caaatgaaca acgtgaaacc tgaggacacc ggagtctact actgtaggct gtacgggagc      300

ggtgactact ggggccaggg gacccaggtc accgtctcct cagcgcacca cagcgaagac      360

ccctcg                                                                 366


<210>  32
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/A holotoxin

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Asp Ile Ser Gly Ile 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Met Val 
        35                  40                  45              


Ala Asp Ile Phe Ser Gly Gly Ser Thr Asp Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Ser Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Val Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg 
                85                  90                  95      


Leu Tyr Gly Ser Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Ala His His Ser Glu Asp Pro Ser 
        115                 120         


<210>  33
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/B holotoxin

<400>  33
caggtgcagc tcgtggagtc aggcggaggc ttggtgcagc ctggggggtc tctgaaactc       60

tcctgtgcag cctctggatt cactttggga caccatcgcg ttggctggtt ccgccaggcc      120

ccaggaaaga agcgtgaggg ggtcgcgtgt attagcgcca ctggtcttag cacacactat      180

tcagactccg tgaccggccg atttaccgtc tccagagaca acctcaacaa cgtggcgtat      240

ctgcagctga acagcctgaa acctgaggac gcaggtgttt attactgtgc aagcagattc      300

tcccttaatt cggtcgatgc gaatatgtgc ctttcagagc ctcagtatga caactggggc      360

caggggaccc aggtcagaat ctcctcagaa cccaagacac caaaaccaca a               411


<210>  34
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/B holotoxin

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Gly His His 
            20                  25                  30          


Arg Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Lys Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Ser Ala Thr Gly Leu Ser Thr His Tyr Ser Asp Ser Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Val Ser Arg Asp Asn Leu Asn Asn Val Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Ala Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Phe Ser Leu Asn Ser Val Asp Ala Asn Met Cys Leu Ser 
            100                 105                 110         


Glu Pro Gln Tyr Asp Asn Trp Gly Gln Gly Thr Gln Val Arg Ile Ser 
        115                 120                 125             


Ser Glu Pro Lys Thr Pro Lys Pro Gln 
    130                 135         


<210>  35
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/B holotoxin

<400>  35
caggtgcagc tcgtggagac gggtggagga ttggtgcagg ccgggggctc tctgagactc       60

tcctgcgcag gctctggacg ctccttcagc gccgctgtca tgggctggtt ccgccaggcg      120

ccagggaagg agcgagaatt cgtagcagca cttagacaaa ttattggtag cacacactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa catgttgtat      240

ctcgacatga acagcctgaa acctacggac acggccgcgt attactgcac agcgggacct      300

ccgactatgc tggacgtttc taccgaccgg gagtatgaca cctggggtca ggggactcag      360

gtcaccgtct cctcagcgca ccacagcgaa gacccctcg                             399


<210>  36
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agents specific to BoNT/B holotoxin

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Arg Ser Phe Ser Ala Ala 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Leu Arg Gln Ile Ile Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Asp Met Asn Ser Leu Lys Pro Thr Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Gly Pro Pro Thr Met Leu Asp Val Ser Thr Asp Arg Glu Tyr 
            100                 105                 110         


Asp Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His 
        115                 120                 125             


Ser Glu Asp Pro Ser 
    130             


<210>  37
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  37
caggtgcagc tcgtggagtc cggaggaggc ttggtgcgac ctggggggtc tctgagactc       60

tcttgtgtag tctctggatt cgcctacgaa atgcccatga tgggctggta ccgccaggct      120

ccagggaatc agcgcgagtt ggtcgcaact attggtacag gtggtaggat gaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca gccgcctatt actgtaaaat cgagtttaca      300

aattactggg gccaggggac ccaagtcacc gtctcctcag aacccaagac accaaaacca      360

caa                                                                    363


<210>  38
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Ala Tyr Glu Met Pro 
            20                  25                  30          


Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Gly Thr Gly Gly Arg Met Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Lys 
                85                  90                  95      


Ile Glu Phe Thr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120     


<210>  39
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  39
caggtgcagc tcgtggagtc aggtggaggc ttggtgcagc cggggggatc tctgagactg       60

tcctgtacag tctctggaag catcttcgat ctacctggaa tgaactggta tcgccaggct      120

ccaggggcgc agcgcgagtt ggtcgcagat attagtagtg atggtaggag gacaaactat      180

gcagactccg tgaagggccg attcaccatg tccagagaca atgccaagaa aacggtgtat      240

ctgcaaatgg acagcctgaa acctgacgac acggccgtct attactgtaa tgtgaaattt      300

actcaccact ggggccaggg gatccaggtc accgtctcct cagaacccaa gacaccaaaa      360

ccacaa                                                                 366


<210>  40
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ser Ile Phe Asp Leu Pro 
            20                  25                  30          


Gly Met Asn Trp Tyr Arg Gln Ala Pro Gly Ala Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ser Ser Asp Gly Arg Arg Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Lys Phe Thr His His Trp Gly Gln Gly Ile Gln Val Thr Val 
            100                 105                 110         


Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120         


<210>  41
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  41
caggtgcagc tcgtggagtc aggcggaggc ttggtgcagc cggggggatc tctgaggctg       60

tcctgtacgg tctctggaag catcttcggc ctacctggca tgagctggta tcgccaggct      120

ccaggggcgc agcgcgagtt ggtcgcagat attagtagtg atggtgggag gacgcactat      180

gcagactccg tgaagggccg cttcaccatc tccagagaca atgacaagaa aacggtgtat      240

ctgcagatgg acagcctgaa acctgacgac acggccgtct attactgtaa tgtgaaattt      300

actcaccact ggggccaggg gatccaggtc accgtctcct cagaacccaa gacaccaaaa      360

ccacaa                                                                 366


<210>  42
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  42

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ser Ile Phe Gly Leu Pro 
            20                  25                  30          


Gly Met Ser Trp Tyr Arg Gln Ala Pro Gly Ala Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Ser Ser Asp Gly Gly Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Lys Phe Thr His His Trp Gly Gln Gly Ile Gln Val Thr Val 
            100                 105                 110         


Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120         


<210>  43
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  43
caggtgcagc tcgtggagtc tgggggaggc ttggtgcagg atggggggtc tctgaggctc       60

tcctgcacaa catctggaag tatcgacagt ttcaatgcca tagagtggta ccgccaggct      120

ccagggaagc agcgcgaatt ggtcgcaagt ataagtagtg atggtcgtcg cacaaactat      180

gcagactccg tgaagggccg attcaccatc tccggagaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acagccgtgt attactgtca tagacctttt      300

acccactact ggggccaggg gacccaggtc accgtctcct cagaacccaa gacaccaaaa      360

ccacaa                                                                 366


<210>  44
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agent

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Asp Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Ser Ile Asp Ser Phe Asn 
            20                  25                  30          


Ala Ile Glu Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Asp Gly Arg Arg Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Arg Pro Phe Thr His Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120         


<210>  45
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agent with tag

<400>  45
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg       60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc      120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac      180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg      240

ctgttcaaaa acggtgaagt ggcggcaacc aaagtgggtg cactgtctaa aggtcagttg      300

aaagagttcc tcgacgctaa cctggccggt tctggttctg gccatatgca ccatcatcat      360

catcattctt ctggtctggt gccacgcggt tctggtatga aagaaaccgc tgctgctaaa      420

ttcgaacgcc agcacatgga cagcccagat ctgggtaccg acgacgacga caaggccatg      480

gcgatatcgg atccgaattc ccaggtgcag ctcgtggagt caggtggagg cttggtgcag      540

gttggggggt ctctgagact ctcctgtgta gtttctggaa gcgacatcag tggcattgcg      600

atgggctggt accgccaggc tccagggaag cggcgcgaaa tggtcgcaga tattttttct      660

ggcggtagta cagactatgc aggctccgtg aagggccgat tcaccatctc cagagacaac      720

gccaagaaga cgagctatct gcaaatgaac aacgtgaaac ctgaggacac cggagtctac      780

tactgtaggc tgtacgggag cggtgactac tggggccagg ggacccaggt caccgtctcc      840

tcagcgcacc acagcgaaga ccccactagt ggtgcgccgg tgccgtatcc ggatccgctg      900

gaaccgcgtt aa                                                          912


<210>  46
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agent with tag

<400>  46

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Ile Ser Asp Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
                165                 170                 175     


Gly Leu Val Gln Val Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser 
            180                 185                 190         


Gly Ser Asp Ile Ser Gly Ile Ala Met Gly Trp Tyr Arg Gln Ala Pro 
        195                 200                 205             


Gly Lys Arg Arg Glu Met Val Ala Asp Ile Phe Ser Gly Gly Ser Thr 
    210                 215                 220                 


Asp Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
225                 230                 235                 240 


Ala Lys Lys Thr Ser Tyr Leu Gln Met Asn Asn Val Lys Pro Glu Asp 
                245                 250                 255     


Thr Gly Val Tyr Tyr Cys Arg Leu Tyr Gly Ser Gly Asp Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu Asp Pro 
        275                 280                 285             


Thr Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
    290                 295                 300             


<210>  47
<211>  924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH binding agent with tag

<400>  47
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg       60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc      120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac      180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg      240

ctgttcaaaa acggtgaagt ggcggcaacc aaagtgggtg cactgtctaa aggtcagttg      300

aaagagttcc tcgacgctaa cctggccggt tctggttctg gccatatgca ccatcatcat      360

catcattctt ctggtctggt gccacgcggt tctggtatga aagaaaccgc tgctgctaaa      420

ttcgaacgcc agcacatgga cagcccagat ctgggtaccg acgacgacga caaggccatg      480

gcgatatcgg atccgaattc ccaggtgcag ctcgtggagt ccggcggagg cttggtgcac      540

cctggggggt ctctgagact ctcttgtgca ccctctgcca gtctaccatc aacacccttc      600

aaccccttca acaatatggt gggctggtac cgtcaggctc caggtaaaca gcgcgaaatg      660

gtcgcaagta ttggtctacg aataaactat gcagactccg tgaagggccg attcaccatc      720

tccagagaca acgccaagaa cacggtggat ctgcagatgg acagcctgcg acctgaggac      780

tcagccacat actactgtca tatagaatac acccactact ggggcaaagg gaccctggtc      840

accgtctcct cggaacccaa gacaccaaaa ccacaaacta gtggtgcgcc ggtgccgtat      900

ccggatccgc tggaaccgcg ttaa                                             924


<210>  48
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH binding agent with tag

<400>  48

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Ile Ser Asp Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
                165                 170                 175     


Gly Leu Val His Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser 
            180                 185                 190         


Ala Ser Leu Pro Ser Thr Pro Phe Asn Pro Phe Asn Asn Met Val Gly 
        195                 200                 205             


Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val Ala Ser Ile 
    210                 215                 220                 


Gly Leu Arg Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
225                 230                 235                 240 


Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met Asp Ser Leu 
                245                 250                 255     


Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys His Ile Glu Tyr Thr His 
            260                 265                 270         


Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Thr 
        275                 280                 285             


Pro Lys Pro Gln Thr Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu 
    290                 295                 300                 


Glu Pro Arg 
305         


<210>  49
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH dimer binding agent with tag

<400>  49
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg       60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc      120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac      180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg      240

ctgttcaaaa acggtgaagt ggcggcaacc aaagtgggtg cactgtctaa aggtcagttg      300

aaagagttcc tcgacgctaa cctggccggt tctggttctg gccatatgca ccatcatcat      360

catcattctt ctggtctggt gccacgcggt tctggtatga aagaaaccgc tgctgctaaa      420

ttcgaacgcc agcacatgga cagcccagat ctgggtaccg acgacgacga caaggccatg      480

gcggccgctc aggtgcagct cgtggagtca ggtggaggct tggtgcaggt tggggggtct      540

ctgagactct cctgtgtagt ttctggaagc gacatcagtg gcattgcgat gggctggtac      600

cgccaggctc cagggaagcg gcgcgaaatg gtcgcagata ttttttctgg cggtagtaca      660

gactatgcag gctccgtgaa gggccgattc accatctcca gagacaacgc caagaagacg      720

agctatctgc aaatgaacaa cgtgaaacct gaggacaccg gagtctacta ctgtaggctg      780

tacgggagcg gtgactactg gggccagggg acccaggtca ccgtctcctc agcgcaccac      840

agcgaagacc ccactagtgc gatcgctggt ggaggcggtt caggcggagg tggctctggc      900

ggtggcggtt ccctgcaggg tcagttgcag ctcgtggagt ccggcggagg cttggtgcac      960

cctggggggt ctctgagact ctcttgtgca ccctctgcca gtctaccatc aacacccttc     1020

aaccccttca acaatatggt gggctggtac cgtcaggctc caggtaaaca gcgcgaaatg     1080

gtcgcaagta ttggtctacg aataaactat gcagactccg tgaagggccg attcaccatc     1140

tccagagaca acgccaagaa cacggtggat ctgcagatgg acagcctgcg acctgaggac     1200

tcagccacat actactgtca tatagaatac acccactact ggggcaaagg gaccctggtc     1260

accgtctcct cggaacccaa gacaccaaaa ccacaaccgg cgcgccaggg tgcgccggtg     1320

ccgtatccgg acccgctgga accgcgttaa                                      1350


<210>  50
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH dimer binding agent with tag

<400>  50

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     


Val Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Asp Ile 
            180                 185                 190         


Ser Gly Ile Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg 
        195                 200                 205             


Glu Met Val Ala Asp Ile Phe Ser Gly Gly Ser Thr Asp Tyr Ala Gly 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr 
225                 230                 235                 240 


Ser Tyr Leu Gln Met Asn Asn Val Lys Pro Glu Asp Thr Gly Val Tyr 
                245                 250                 255     


Tyr Cys Arg Leu Tyr Gly Ser Gly Asp Tyr Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Ala His His Ser Glu Asp Pro Thr Ser Ala Ile 
        275                 280                 285             


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Leu Gln Gly Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val His 
305                 310                 315                 320 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser Ala Ser Leu Pro 
                325                 330                 335     


Ser Thr Pro Phe Asn Pro Phe Asn Asn Met Val Gly Trp Tyr Arg Gln 
            340                 345                 350         


Ala Pro Gly Lys Gln Arg Glu Met Val Ala Ser Ile Gly Leu Arg Ile 
        355                 360                 365             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    370                 375                 380                 


Ala Lys Asn Thr Val Asp Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
385                 390                 395                 400 


Ser Ala Thr Tyr Tyr Cys His Ile Glu Tyr Thr His Tyr Trp Gly Lys 
                405                 410                 415     


Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
            420                 425                 430         


Pro Ala Arg Gln Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro 
        435                 440                 445             


Arg 
    


<210>  51
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH dimer binding agent with two tags

<400>  51
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg       60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc      120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac      180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg      240

ctgttcaaaa acggtgaagt ggcggcaacc aaagtgggtg cactgtctaa aggtcagttg      300

aaagagttcc tcgacgctaa cctggccggt tctggttctg gccatatgca ccatcatcat      360

catcattctt ctggtctggt gccacgcggt tctggtatga aagaaaccgc tgctgctaaa      420

ttcgaacgcc agcacatgga cagcccagat ctgggtaccg acgacgacga caaggccatg      480

gcgatatcgg atccgaattc tggcgcacct gtcccatacc cagaccctct ggaaccacga      540

gcggccgctc aggtgcagct cgtggagtca ggtggaggct tggtgcaggt tggggggtct      600

ctgagactct cctgtgtagt ttctggaagc gacatcagtg gcattgcgat gggctggtac      660

cgccaggctc cagggaagcg gcgcgaaatg gtcgcagata ttttttctgg cggtagtaca      720

gactatgcag gctccgtgaa gggccgattc accatctcca gagacaacgc caagaagacg      780

agctatctgc aaatgaacaa cgtgaaacct gaggacaccg gagtctacta ctgtaggctg      840

tacgggagcg gtgactactg gggccagggg acccaggtca ccgtctcctc agcgcaccac      900

agcgaagacc ccactagtgc gatcgctggt ggaggcggtt caggcggagg tggctctggc      960

ggtggcggtt ccctgcaggg tcagttgcag ctcgtggagt ccggcggagg cttggtgcac     1020

cctggggggt ctctgagact ctcttgtgca ccctctgcca gtctaccatc aacacccttc     1080

aaccccttca acaatatggt gggctggtac cgtcaggctc caggtaaaca gcgcgaaatg     1140

gtcgcaagta ttggtctacg aataaactat gcagactccg tgaagggccg attcaccatc     1200

tccagagaca acgccaagaa cacggtggat ctgcagatgg acagcctgcg acctgaggac     1260

tcagccacat actactgtca tatagaatac acccactact ggggcaaagg gaccctggtc     1320

accgtctcct cggaacccaa gacaccaaaa ccacaaccgg cgcgccaggg tgcgccggtg     1380

ccgtatccgg acccgctgga accgcgttaa                                      1410


<210>  52
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH dimer binding agent with two tags

<400>  52

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Ile Ser Asp Pro Asn Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro 
                165                 170                 175     


Leu Glu Pro Arg Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
            180                 185                 190         


Gly Leu Val Gln Val Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser 
        195                 200                 205             


Gly Ser Asp Ile Ser Gly Ile Ala Met Gly Trp Tyr Arg Gln Ala Pro 
    210                 215                 220                 


Gly Lys Arg Arg Glu Met Val Ala Asp Ile Phe Ser Gly Gly Ser Thr 
225                 230                 235                 240 


Asp Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                245                 250                 255     


Ala Lys Lys Thr Ser Tyr Leu Gln Met Asn Asn Val Lys Pro Glu Asp 
            260                 265                 270         


Thr Gly Val Tyr Tyr Cys Arg Leu Tyr Gly Ser Gly Asp Tyr Trp Gly 
        275                 280                 285             


Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu Asp Pro 
    290                 295                 300                 


Thr Ser Ala Ile Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Leu Gln Gly Gln Leu Gln Leu Val Glu Ser Gly Gly 
                325                 330                 335     


Gly Leu Val His Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser 
            340                 345                 350         


Ala Ser Leu Pro Ser Thr Pro Phe Asn Pro Phe Asn Asn Met Val Gly 
        355                 360                 365             


Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val Ala Ser Ile 
    370                 375                 380                 


Gly Leu Arg Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
385                 390                 395                 400 


Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met Asp Ser Leu 
                405                 410                 415     


Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys His Ile Glu Tyr Thr His 
            420                 425                 430         


Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Thr 
        435                 440                 445             


Pro Lys Pro Gln Pro Ala Arg Gln Gly Ala Pro Val Pro Tyr Pro Asp 
    450                 455                 460                 


Pro Leu Glu Pro Arg 
465                 


<210>  53
<211>  109
<212>  PRT
<213>  Clostridium botulinum

<400>  53

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala 
            100                 105                 
<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  54

Gly Gly Gly Gly Ser 
1               5   


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  56
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  56

Leu Val Gln Val Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly 
1               5                   10                  15      


Ser Asp Ile Ser Gly Ile Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Arg Arg Glu Met Val Ala Asp Ile Phe Ser Gly Gly Ser Thr Asp 
        35                  40                  45              


Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    50                  55                  60                  


Lys Lys Thr Ser Tyr Leu Gln Met Asn Asn Val Lys Pro Glu Asp Thr 
65                  70                  75                  80  


Gly Val Tyr Tyr Cys Arg Leu Tyr Gly Ser Gly Asp Tyr Trp Gly Gln 
                85                  90                  95      


Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu Asp Pro 
            100                 105                 110     


<210>  57
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  57

Leu Val His Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Pro Ser Ala 
1               5                   10                  15      


Ser Leu Pro Ser Thr Pro Phe Asn Pro Phe Asn Asn Met Val Gly Trp 
            20                  25                  30          


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val Ala Ser Ile Gly 
        35                  40                  45              


Leu Arg Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met Asp Ser Leu Arg 
65                  70                  75                  80  


Pro Glu Asp Ser Ala Thr Tyr Tyr Cys His Ile Glu Tyr Thr His Tyr 
                85                  90                  95      


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Thr Pro 
            100                 105                 110         


Lys Pro Gln 
        115 


<210>  58
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Asp Ile Ser Gly Ile 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Met Val 
        35                  40                  45              


Ala Asp Ile Phe Ser Gly Gly Ser Thr Asp Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Ser Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Val Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg 
                85                  90                  95      


Leu Tyr Gly Ser Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Ala His His Ser Glu Asp Pro Thr Ser Ala Ile Ala Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Gly 
    130                 135                 140                 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Pro Ser Ala Ser Leu Pro Ser Thr Pro 
                165                 170                 175     


Phe Asn Pro Phe Asn Asn Met Val Gly Trp Tyr Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gln Arg Glu Met Val Ala Ser Ile Gly Leu Arg Ile Asn Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Val Asp Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Ser Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys His Ile Glu Tyr Thr His Tyr Trp Gly Lys Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
            260                 265                 


<210>  59
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  59

Gln Val Gln Leu Val Glu Thr Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser Ser 
            20                  25                  30          


Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
        35                  40                  45              


Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr Gly 
            100                 105                 110         


Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             


Lys Thr Pro Lys Pro Gln Pro 
    130                 135 


<210>  60
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  60

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120                 125             


Gln Pro 
    130 


<210>  61
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  61

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Val Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Gln Ser Pro Ile Pro Ile His Tyr Ser Arg Thr Tyr Ser 
            100                 105                 110         


Gly Pro Tyr Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala His His Ser Glu Asp Pro 
    130                 135         


<210>  62
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  62

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Gly Ile Ser Phe Val Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Gly Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Gln Ser Ser Ile Pro Met His Tyr Ser Ser Thr Tyr Ser 
            100                 105                 110         


Gly Pro Ser Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Pro 
    130                 135                 


<210>  63
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  63

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Asn Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Arg Ile Ala Asp Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Trp Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Gly Pro Gly Ala Phe Pro Gly Met Val Val Thr Asn Pro Ser 
            100                 105                 110         


Ala Tyr Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Thr Pro Lys Pro Gln Pro 
    130                 135     


<210>  64
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  64

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Gln Ala Ala Ile Pro Met His Tyr Ser Ala Ser Tyr Ser 
            100                 105                 110         


Gly Pro Arg Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Pro 
    130                 135                 


<210>  65
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Glu Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Lys Thr Lys Leu Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Asp Ala Ser Ala Ser Asn Arg Trp Leu Ala Ala 
            100                 105                 110         


Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Thr Pro Lys Pro Gln 
    130                 135 


<210>  66
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ser Ser Glu Arg Asn Pro Gly Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Ser Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ile Trp Gln Thr Gly Gly Ser Leu Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Leu Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Leu Lys Lys Trp Arg Asp Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120             


<210>  67
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            100                 105                 110         


Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Thr Pro Lys Pro Gln 
    130                 135 


<210>  68
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
            20                  25                  30          


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys 
                85                  90                  95      


Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser Glu 
            100                 105                 110         


Pro Lys Thr Pro Lys Pro Gln 
        115                 


<210>  69
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Thr Gly Ser Ser Phe Ser Thr Ser 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Pro Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Ser Phe Thr Ser Gly Gly Ala Ile Lys Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Lys Met Thr Tyr Leu 
65                  70                  75                  80  


Gln Met Glu Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Leu His Asn Ala Val Ser Gly Ser Ser Trp Gly Arg Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 


<210>  70
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  70

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Met Phe Gly Ala Met Thr 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val Ala 
        35                  40                  45              


Tyr Ile Thr Ala Gly Gly Thr Glu Ser Tyr Ser Glu Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Ile Asn Ala Asn Asn Met Val Tyr Leu Gln 
65                  70                  75                  80  


Met Thr Asn Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Asn Phe Trp Arg Thr Ser Arg Asn Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120             


<210>  71
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  71

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser 
1               5                   10                  15      


Leu Thr Leu Ser Cys Ala Ala Ser Glu Ser Thr Phe Asn Thr Phe Ser 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val Ala 
        35                  40                  45              


Ala Phe Ser Arg Ser Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


His Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Asp Arg Pro Ala Gly Arg Ala Tyr Phe Gln Ser Arg Ser Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser 
        115                 120                 125             


Glu Asp Pro 
    130     


<210>  72
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  72

Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ile Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Lys Asn Ile 
            20                  25                  30          


Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Thr Ile Ser Ile Gly Gly Ala Ala Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asp Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Gly Pro Arg Thr Tyr Ile Asn Thr Ala Ser Arg Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120                 125 


<210>  73
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  73

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val Gly Ser Gly Arg Asn Pro Gly Ile Asn Ala 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Ser Gln Arg Glu Leu Val Ala 
        35                  40                  45              


Val Trp Gln Thr Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Leu Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Leu 
                85                  90                  95      


Lys Lys Trp Arg Asp Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Ala His His Ser Glu Asp Pro 
        115                 120     


<210>  74
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  74

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val Val Ser Glu Ser Ile Phe Arg Ile Asn Thr 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Val Val Ala 
        35                  40                  45              


Arg Ile Thr Leu Arg Asn Ser Thr Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu Tyr Leu Lys 
65                  70                  75                  80  


Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Arg 
                85                  90                  95      


Tyr Pro Leu Ile Phe Arg Asn Ser Pro Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120                 


<210>  75
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  75

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val Val Ser Glu Ser Ile Phe Arg Ile Asn Thr 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Val Val Ala 
        35                  40                  45              


Arg Ile Thr Leu Arg Asn Ser Thr Thr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Leu Tyr Leu Lys 
65                  70                  75                  80  


Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Arg 
                85                  90                  95      


Tyr Pro Leu Ile Phe Arg Asn Ser Pro Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro 
        115                 120         


<210>  76
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  76

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Pro Gly Leu Thr Phe Thr Ser Tyr Arg 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val Ala 
        35                  40                  45              


Ala Ile Thr Gly Ala Gly Ala Thr Asn Tyr Ala Asp Ser Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Asn Asn Thr Ala Ser Thr Val His Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Ser Asn Arg Ala Gly Gly Tyr Trp Arg Ala Ser Gln Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu Asp 
        115                 120                 125             


Pro 
    


<210>  77
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  77

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ala Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Glu Pro Gly Arg Thr Leu Asp Met Tyr 
            20                  25                  30          


Ala Met Gly Trp Ile Arg Gln Ala Pro Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ser Gly Val Gly Gly Ser Pro Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Ser Thr Ile Trp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Asp Ile Tyr Tyr Gly Gly Ser Pro Gln Trp Arg Gly 
            100                 105                 110         


Gln Gly Thr Arg Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120                 125             


Gln 
    


<210>  78
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Asn Gly Asp Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Asn Ser Trp Ile Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly His Tyr Thr Asp Phe Pro Thr Tyr Phe Lys Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr 
        115                 120                 125             


Pro Lys Pro Gln 
    130         


<210>  79
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  79

Gln Val Gln Leu Val Glu Thr Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Pro Phe Ser Asp Tyr Thr 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val Ala 
        35                  40                  45              


Arg Ile Thr Trp Arg Gly Gly Gly Pro Tyr Tyr Gly Asn Ser Gly Asn 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Ile Ala Lys Ser Met Val Tyr Leu 
65                  70                  75                  80  


His Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Arg Leu Arg Pro Ala Leu Ala Ser Met Ala Ser Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Ser Val Ser Ser Glu Pro Lys Thr 
        115                 120                 125             


Pro Lys Pro Gln 
    130         


<210>  80
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Ala Ser Thr Phe Ser Thr Ser 
            20                  25                  30          


Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              


Ala Glu Val Arg Thr Thr Gly Gly Thr Phe Tyr Ala Lys Ser Val Ala 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Gly Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Gly Ala Gly Pro Ile Ala Thr Arg Tyr Arg Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala His His Ser Glu Asp Pro 
        115                 120                 


<210>  81
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  81

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ala Asp Tyr 
            20                  25                  30          


Val Thr Val Trp Phe Arg Gln Ala Pro Gly Lys Ser Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Arg Gly Thr Pro Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Val Ser Arg Asn Asn Ala Asn Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ile Arg Pro Ala Arg Leu Arg Ala Tyr Arg Glu Cys Leu Ser 
            100                 105                 110         


Ser Gln Ala Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala His His Ser Glu Asp Pro 
    130                 135         


<210>  82
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  82

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Met Ser Gly Thr Thr Gln Asp Tyr Ser 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Ser Gly Arg Arg Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Lys Thr Asp Met Ser Asp Pro Tyr Tyr Val Gly Cys Asn 
            100                 105                 110         


Gly Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


His His Ser Glu Asp Pro 
    130                 


<210>  83
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  83

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Thr Ala Ser Gly Phe Thr Leu Asn Ser Tyr 
            20                  25                  30          


Lys Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Asn Ser Gly Gly Asn Leu Arg Ser Val Glu Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Ser Leu His Met Asp 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr His Cys Ala Ala Ala Pro 
                85                  90                  95      


Ala Leu Asn Val Phe Ser Pro Cys Val Leu Ala Pro Arg Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu 
        115                 120                 125             


Asp Pro 
    130 


<210>  84
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Gly Ser Tyr 
            20                  25                  30          


His Ile Gly Trp Phe Arg His Pro Pro Gly Lys Glu Arg Glu Gly Thr 
        35                  40                  45              


Ser Cys Leu Ser Ser Arg Gly Asp Tyr Thr Lys Tyr Ala Glu Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Gly Ile Tyr Val Cys 
                85                  90                  95      


Ala Ala Ile Arg Pro Val Leu Ser Asp Ser His Cys Thr Leu Ala Ala 
            100                 105                 110         


Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


His His Ser Glu Asp Pro 
    130                 


<210>  85
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Leu Glu Phe Thr Leu Glu Asp Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Lys Ser Gly Val Thr Lys Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Val Ala Arg Asp Asn Ala Lys Ser Thr Val Ile Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Pro Glu Asp Thr Ala Val Tyr Asn Cys Ala 
                85                  90                  95      


Ala Val Arg Pro Val Phe Val Asp Ser Val Cys Thr Leu Ala Thr Arg 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Glu Gly Thr Gln Val Thr Val Ser Ser Ala His 
        115                 120                 125             


His Ser Glu Asp Pro 
    130             


<210>  86
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  86

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Glu Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Asn Lys Arg Gly Asp Tyr Ile Asn Tyr Lys Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala Lys Ser Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Asn Pro Val Phe Pro Asp Ser Arg Cys Thr Leu Ala Thr 
            100                 105                 110         


Arg Tyr Thr His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


His His Ser Glu Asp Pro 
    130                 



<210>  87
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  87

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Ile Ser Asp Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
                165                 170                 175     


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser 
            180                 185                 190         


Gly Phe Thr Leu Asp Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Pro Pro 
        195                 200                 205             


Gly Lys Glu Arg Glu Ala Val Ser Tyr Ile Ser Ala Ser Ala Arg Thr 
    210                 215                 220                 


Ile Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
225                 230                 235                 240 


Asn Ala Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Arg Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Phe Ser Ala Ser Ser 
            260                 265                 270         


Val Asn Arg Trp Leu Ala Asp Asp Tyr Asp Val Trp Gly Arg Gly Thr 
        275                 280                 285             


Gln Val Ala Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Thr Ser 
    290                 295                 300                 


Ala Ile Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Leu Gln Ala Met Ala Ala Ala Ser Gln Val Gln Leu Val Glu 
                325                 330                 335     


Ser Gly Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys 
            340                 345                 350         


Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg 
        355                 360                 365             


Gln Ala Pro Gly Lys Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr 
    370                 375                 380                 


Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser 
385                 390                 395                 400 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
                405                 410                 415     


Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly 
            420                 425                 430         


Gln Gly Ile Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        435                 440                 445             


Gln Pro Ala Arg Arg 
    450             


<210>  88
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  88

Gln Leu Gln Leu Val Glu 
1               5       


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  89

Gln Val Gln Leu Val Glu 
1               5       


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  90
tttgtttatc caccgaacta ag                                                22


<210>  91
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  91
tcttcagaaa gggatccacc ag                                                22


<210>  92
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  92
tggtggatcc ctttctgaag ac                                                22


<210>  93
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  93
actgctccag tttcccac                                                     18


<210>  94
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  94

Thr Ser Pro Ser Thr Val Arg Leu Glu Ser Arg Val Arg Glu Leu Glu 
1               5                   10                  15      


Asp Arg Leu Glu Glu Leu Arg Asp Glu Leu Glu Arg Ala Glu Arg Arg 
            20                  25                  30          


Ala Asn Glu Met Ser Ile Gln Leu Asp Glu Cys 
        35                  40              


<210>  95
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  95

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Ile Ser Asp Pro Asn Ser Gln Val Gln Leu Val Glu Thr Gly Gly 
                165                 170                 175     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            180                 185                 190         


Phe Thr Leu Asp Tyr Ser Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Arg Glu Gly Val Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr 
    210                 215                 220                 


Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn 
225                 230                 235                 240 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp 
                245                 250                 255     


Thr Ala Val Tyr Tyr Cys Ala Ala Phe Arg Ala Thr Met Cys Gly Val 
            260                 265                 270         


Phe Pro Leu Ser Pro Tyr Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Pro Thr Ser 
    290                 295                 300                 


Ala Ile Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Leu Gln Ala Met Ala Ala Ala Gln Leu Gln Leu Val Glu Thr 
                325                 330                 335     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            340                 345                 350         


Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Thr Trp Val Arg Gln 
        355                 360                 365             


Ala Pro Gly Lys Gly Pro Glu Trp Ile Ala Thr Ile Asn Thr Asp Gly 
    370                 375                 380                 


Ser Thr Met Arg Asp Asp Ser Thr Lys Gly Arg Phe Thr Ile Ser Arg 
385                 390                 395                 400 


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr Ser Leu Lys Pro 
                405                 410                 415     


Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Arg Val Ile Ser Ala 
            420                 425                 430         


Ser Ala Ile Arg Gly Ala Val Arg Gly Pro Gly Thr Gln Val Thr Val 
        435                 440                 445             


Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Pro Ala Arg Gln Thr Ser 
    450                 455                 460                 


Pro Ser Thr Val Arg Leu Glu Ser Arg Val Arg Glu Leu Glu Asp Arg 
465                 470                 475                 480 


Leu Glu Glu Leu Arg Asp Glu Leu Glu Arg Ala Glu Arg Arg Ala Asn 
                485                 490                 495     


Glu Met Ser Ile Gln Leu Asp Glu Cys 
            500                 505 


<210>  96
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  96

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Pro Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Val Ser Arg Tyr 
            20                  25                  30          


Asp Lys Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Asn Gly Asp Thr Lys Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ser Arg Asp Thr Leu Asp 
65                  70                  75                  80  


Leu Gln Ile Asp Asn Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Ile Ala Gly Val Gln Ser Met Ala Arg Met Leu Gly Val 
            100                 105                 110         


Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
        115                 120                 125             


Thr Pro Lys Pro Gln 
    130             


<210>  97
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  97
caggtgcagc tcgtggagac ggggggagga ttggtgcagg ctggggaccc tctgagactc       60

tcctgtgtag cctctggacg caccgtcagt cgctatgaca aggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagga attagctgga acggcgatac aaaaatttat      180

gcagactccg tgaagggccg attcaccatc tccagagaga actccaggga tacactggat      240

ctgcaaattg acaacctgaa acctgaggac acggccgcgt attactgtgc ggtcggaatt      300

gcgggtgttc agagtatggc gcgtatgctc ggagtgcgct actggggcca ggggacccag      360

gtcaccgtct cctcagaacc caagacacca aaaccacaa                             399


<210>  98
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  98

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Pro Tyr 
            20                  25                  30          


Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Thr Ser Arg Ala Ala Ser Arg Thr Ser Val Asp Ser Val 
    50                  55                  60                  


Asn Glu Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu His Ile Asn Asn Leu Lys Pro Glu Asp Ser Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Pro Ala Lys Leu Pro Leu Phe Ser Leu Cys Arg Ser 
            100                 105                 110         


Leu Pro Ala Lys Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala His His Ser Glu Asp Pro Ser 
    130                 135             


<210>  99
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  99
caggtgcagc tcgtggagac ggggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggttt cagtttggac ccttatgtga taggatggtt ccggcaggcc      120

ccagggaagg agcgtgaggg ggtctcatgt attacgagta gggctgctag tcgaacgtct      180

gtagactccg tgaacgagcg attcaccatc tccagagaca acgccaagaa tacggtcgat      240

ctacacatca ataacctgaa acctgaggac tcgggcgttt attactgtgc agcggtcccc      300

cctgccaaat taccactttt cagcctatgt cgctccctgc cagcaaagta tgactactgg      360

ggccagggga cccaggtcac cgtctcctca gcgcaccaca gcgaagaccc ctcg            414


<210>  100
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  100

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Asn Ile Asn Ser Arg Gly Thr Ser Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Glu Trp Leu Gly Arg Ser Glu Pro Ser Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125 


<210>  101
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  101
caggtgcagc tcgtggagtc ggggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag tagcttcagt agatatgcca tgcgctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcaaac attaatagtc gtggtacctc aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaagacacg gccgtctatt attgtaatgc agagtggttg      300

ggacgatcgg agccttcctg gggccagggg acccaggtca ccgtctcctc ggaacccaag      360

acaccaaaac cacaa                                                       375


<210>  102
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  102

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Leu Tyr 
            20                  25                  30          


Thr Met Arg Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Ala Thr Gly Ile Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asp Ala Lys Lys Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Val Arg Thr Thr Val Ser Arg Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125     


<210>  103
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  103
caggtgcagc tcgtggagtc aggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cattttcagt ctttatacca tgaggtggca ccgccaggct      120

ccagggaagg agcgcgagtt ggtcgcgact attactagtg ctactggtat tacaaactat      180

gcagactccg tgaagggccg attcatcatc tccagagacg atgccaagaa gacggggtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgtgt attactgtaa tgcagtccgc      300

actaccgtgt cacgagacta ctggggccag gggacccagg tcaccgtctc ctcagaaccc      360

aagacaccaa aaccacaa                                                    378


<210>  104
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Ile Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Pro Ser Gly Pro Ser Ala Asn Ala Thr Asp Ser Val Gly 
    50                  55                  60                  


Gly Arg Phe Thr Ile Thr Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Arg Gly Pro Gly Ile Lys Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125 


<210>  105
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  105
caggtgcagc tcgtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaat catcttcagt atctatacca tgggctggta ccgccaggct      120

ccagggaagc agcgcgaatt ggtcgcagct atacctagtg gtcctagcgc aaacgctaca      180

gactccgtgg ggggccgatt caccatcacc agagacaacg ccgagaacac ggtgtatctg      240

caaatgaacg acctgaaacc tgaggacacg gccgtctatt actgtaatgc tcggcggggt      300

ccgggtatca aaaactactg gggccagggg acccaggtca ccgtctcctc agaacccaag      360

acaccaaaac cacaa                                                       375


<210>  106
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  106

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Val Ser Cys Ala Ala Ser Gly Ser Ile Ala Arg Pro Gly 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Pro Gly Gly Leu Thr Asn Tyr Ala Asp Ser Val Thr 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Arg Ile Ile Pro Leu Gly Leu Gly Ser Glu Tyr Arg Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu Asp 
        115                 120                 125             


Pro Ser 
    130 


<210>  107
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  107
caggtgcagc tcgtggagtc cgggggcggc ttggtgcagc ccggggggtc tctgagtgtc       60

tcctgtgcag cctctggaag catcgcaaga ccaggtgcca tggcctggta ccgccaggct      120

ccagggaagg agcgcgagtt ggtcgcgtct attacgcctg gtggtcttac aaactatgcg      180

gactccgtga cgggccgatt caccatttcc agagacaacg ccaagaggac ggtgtatctg      240

cagatgaaca gcctccaacc cgaggacacg gccgtctatt actgtcatgc acgaataatt      300

cccctaggac ttgggtccga atacagggac cactggggcc aggggactca ggtcaccgtc      360

tcctcagcgc accacagcga agacccctcg                                       390


<210>  108
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  108

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Val Ala Ser Gly Arg Ser Ile Asn Asn 
            20                  25                  30          


Tyr Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Gln Ile Ser Ser Gly Gly Thr Thr Asn Tyr Ala Gly Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Lys Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Leu Leu Arg Thr Phe Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Ala His His Ser Glu Asp Pro Ser 
        115                 120             


<210>  109
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  109
caggtgcagc tcgtggagac ggggggaggc ttggtgcagc ctggggggtc tctgggactc       60

tcctgtgtag tcgcctctgg aagaagcatc aataattatg gcatgggctg gtaccgccag      120

gctccaggga agcagcgcga gttggtcgcg caaattagta gtggtggtac cacaaattat      180

gcaggctccg tagagggccg attcaccatc tccagagaca acgtcaagaa aatggtgtat      240

cttcaaatga acagcctgaa acctgaggac acggccgtct attactgtaa ttcactgctc      300

cgaacttttt cctggggcca ggggacccag gtcaccgtct cctcggcgca ccacagcgaa      360

gacccctcg                                                              369


<210>  110
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  110

Gln Val Gln Leu Val Glu Thr Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Thr Ala 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        35                  40                  45              


Arg Ile Ser Gly Ala Gly Ile Thr Ile Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asn Asn Val Glu Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Asn Thr Tyr Thr Ser Asp Tyr Asn Ile Pro Ala Arg Tyr 
            100                 105                 110         


Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
        115                 120                 125             


Thr Pro Lys Pro Gln 
    130             


<210>  111
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  111
caggtgcagc tcgtggagac cggggggttg gtgcagcctg ggggctccct gcgactctcc       60

tgtgcagcct ccggactcac cttcagtagc actgccatgg cctggttccg ccaggctcca      120

gggaaggagc gtgagtttgt agcacgtatt agcggggctg gtattacgat ctactattcg      180

gactccgtga aggaccgatt caccatctcc agaaacaacg tcgagaacac ggtgtatttg      240

caaatgaaca gcctgaaaac tgaggacacg gccgtttact actgtgcagc aagacggaat      300

acttacacta gcgactataa catacccgcc cggtatccct actggggcca ggggacccag      360

gtcaccgtct cctcagaacc caagacacca aaaccacaa                             399


<210>  112
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  112

Gln Val Gln Leu Val Glu Thr Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Thr Thr Ala Thr Ile Tyr 
            20                  25                  30          


Ser Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Met Thr Ser Asp Gly Gln Thr Asn Tyr Ala Thr Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Leu Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Val Lys Pro Trp Arg Leu Gln Gly Trp Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125     


<210>  113
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  113
caggtgcagc tcgtggagac ggggggcttg gtgcagcctg gggggtctct gagactctcc       60

tgtgcagcct ctagaagcac gacggccaca atttatagta tgaactggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgggt atgactagtg atggtcagac aaactatgca      180

acctccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtatatttg      240

ctaatgaaca gcctgaaact tgaggacacg gccgtctatt attgttatgt aaaaccatgg      300

agactacaag gttgggacta ctggggccag gggacccagg tcaccgtctc ctcagaaccc      360

aagacaccaa aaccacaa                                                    378


<210>  114
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  114

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Glu Ser Ile Val Asn Ser Arg 
            20                  25                  30          


Thr Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Arg Val 
        35                  40                  45              


Ala Thr Ile Thr Thr Ala Gly Ser Pro Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Leu Leu Ser Thr Leu Pro Tyr Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Ala His His Ser Glu Asp Pro Ser 
        115                 120         


<210>  115
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  115
caggtgcagc tcgtggagtc gggcggcggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cccctgaaag catcgtcaat agcagaacca tggcctggta ccgccaggct      120

ccaggaaagc agcgcgaaag ggtcgccact attactactg ctggtagccc aaattatgca      180

gactctgtga agggccgatt cgccatctcc agagacaacg ccaagaacac ggtatatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtctatt actgcaatac acttctcagc      300

acccttccct atggccaggg gacccaggtc accgtctcct cggcgcacca cagcgaagac      360

ccctcg                                                                 366


<210>  116
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  116

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Val Val Ala Ser Glu Arg Ser Ile Asn Asn 
            20                  25                  30          


Tyr Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              


Val Ala Gln Ile Ser Ser Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Lys Met Val His 
65                  70                  75                  80  


Leu Gln Val Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Leu Leu Arg Thr Phe Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120             


<210>  117
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  117
caggtgcagc tcgtggagtc gggcggaggc ttggtgcagc ctggggggtc tctgggactc       60

tcctgtgtag tcgcctctga aagaagcatc aataattatg gcatgggctg gtaccgccag      120

gctccaggga agcagcgcga gttggtcgcg caaattagta gtggtggtac cacaaattat      180

gcagactccg tagagggccg attcaccatc tccagagaca acgtcaagaa aatggtgcat      240

cttcaagtga acagcctgaa acctgaggac acggccgtct attactgtaa ttcgctactc      300

cgaacttttt cctggggcca ggggacccag gtcaccgtct cctcggaacc caagacacca      360

aaaccacaa                                                              369


<210>  118
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  118

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Ser Trp Tyr Arg Gln Ala Ala Gly Lys Glu Arg Asp Val Val 
        35                  40                  45              


Ala Thr Ile Thr Ala Asn Gly Val Pro Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Pro Arg Leu His Thr Ser Val Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125     


<210>  119
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  119
caggtgcagc tcgtggagac gggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatcgca tgagctggta ccggcaggct      120

gcagggaagg agcgcgacgt ggtcgcaaca attactgcta atggtgttcc cacaggctat      180

gcagactccg tgatgggccg attcaccatt tccagagaca atgccaagaa cacggtgtat      240

ctggaaatga acagcctgaa tcctgaggac acggccgtgt attactgtaa cgcgccccgt      300

ttgcatacat ctgtaggcta ctggggccag gggacccagg tcaccgtctc ctcagaaccc      360

aagacaccaa aaccacaa                                                    378


<210>  120
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Ile Phe Ser Ile Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Val Ala Asp Gly Thr Ala Leu Val Ala Asp Ser Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Tyr Leu Ser Pro Arg Val Gln Ser Pro Tyr Ile Thr Asp Ser 
            100                 105                 110         


Arg Tyr Gln Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Thr Pro Lys Pro Gln 
    130                 135 


<210>  121
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  121
caggtgcagc tcgtggagtc gggaggagga ttggtgcagg ctgggaactc tctgagactc       60

tcctgtacgg cctctggtgt gatcttctct atctatacca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagcg ataggggtgg ctgatggtac cgcacttgtg      180

gcagactccg tgacgggccg attcaccatc tccagagaca acgccaagaa caccgtttat      240

ctgcatatga acagcctgaa gcctgaggac acggccgtct attcctgtgc agcgtatctt      300

agcccccgtg tccaatcccc ctacataact gactcccggt atcaactctg gggccagggg      360

acccaggtca ccgtctcctc agaacccaag acaccaaaac cacaa                      405


<210>  122
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  122

Thr Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Arg Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Glu Arg Glu Phe Val Ala Thr Ile Ser Arg Ser Gly Ala Ile Arg 
        35                  40                  45              


Glu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly 
    50                  55                  60                  


Ala Glu Asn Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Asp Asp 
65                  70                  75                  80  


Thr Ala Ile Tyr Val Cys Ala Glu Gly Arg Gly Ala Thr Phe Asn Pro 
                85                  90                  95      


Glu Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
            100                 105                 110         


His His Ser Glu Asp Pro Ser 
        115                 


<210>  123
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  123
caggtgcagc tcgtggagac tgggggagga ttggtgcagg ctgggggctc tctgaggctc       60

tcctgtgcag cctctggacg ctatgccatg ggctggttcc gccaggctcc agggaaggag      120

cgtgaatttg tagcgactat tagccggagt ggtgctatca gagagtatgc agactccgtg      180

aagggccgat tcaccatctc cagagacggc gccgagaaca cggtgtatct ggaaatgaac      240

agcctgaaac ctgacgacac ggccatttat gtctgtgcag aaggacgagg ggcgacattc      300

aaccccgagt atgcttactg gggccagggg acccaggtca ccgtctcctc agcgcaccac      360

agcgaagacc cctcg                                                       375


<210>  124
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  124

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Val Lys Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Gly Ala Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Arg Pro 
                85                  90                  95      


Cys Phe Leu Gly Val Pro Leu Ile Asp Phe Gly Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125         


<210>  125
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  125
caggtgcagc tcgtggagtc gggcggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttggat gattatgcca taggctggtt ccgccaggtc      120

ccagggaagg agcgtgaggg ggtcgcatgt gttaaagatg gtagtacata ctatgcagac      180

tccgtgaagg gccgattcac catctccaga gacaacggcg cggtgtatct gcaaatgaac      240

agcctgaaac ctgaggacac agccgtttat tactgtgcat ccaggccctg ctttttgggt      300

gtaccactta ttgactttgg ttcctggggc caggggaccc aggtcaccgt ctcctcggaa      360

cccaagacac caaaaccaca a                                                381


<210>  126
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  126

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Gly Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Arg Asn Gly Asn Gly Gly Asn Gly Ile Glu Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val His Leu Gln Met Asn Ser Leu Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Ile Ser Gly Tyr Ala Tyr Asn Thr Ile Glu 
            100                 105                 110         


Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Thr Pro Lys Pro Gln 
    130                 135 


<210>  127
<211>  406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  127
caggtgcagc tcgtggagtc agggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgcgcaa cctctggcgg caccttcagt gactatggaa tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggcgga atggtaatgg cggtaatggc      180

attgaatatg cagactccgt gaagggccga ttcaccatct ccagagacaa cgccaagaac      240

acggtgcatc tacaaatgaa cagcctgaca cctgaggaca cggccgttta ttactgtgca      300

gcgtcaatat cgggatacgc ttataacaca attgaaagat ataactactg gggccaggga      360

acccaggtca ccgtctcctc aggaacccaa gacaccaaaa ccacaa                     406


<210>  128
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  128

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Gly Asp Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Trp Thr Gly Ser Gly Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Val Phe Ala Glu Ile Thr Gly Leu Ala Gly Tyr Gln 
            100                 105                 110         


Ser Gly Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Glu Pro Lys Thr Pro Lys Pro Gln 
    130                 135         


<210>  129
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  129
caggtgcagc tcgtggagtc cggcggagga ttggtgcagg cggggggctc tctgagtctc       60

tcctgtgcag cctctggagg tgacttcagt aggaatgcca tggcctggtt ccgtcaggct      120

ccagggaagg agcgtgaatt tgtagcatct attaactgga ctggtagtgg cacatattat      180

ctagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cgccctgtat      240

ctgcaaatga acaacctgaa acctgaggac acggccgttt attactgtgc acgctccacg      300

gtgtttgccg aaattacagg cttagcaggc taccagtcgg gatcgtatga ctactggggc      360

caggggaccc aggtcaccgt ctcctcagaa cccaagacac caaaaccaca a               411


<210>  130
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  130

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Thr Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Gly Ser Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Ala Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Leu Asn Ser Leu Lys Leu Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Ser Val Tyr Ala Glu Met Pro Tyr Ala Asp Ser Val Lys 
            100                 105                 110         


Ala Thr Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Glu Pro Lys Thr Pro Lys Pro Gln 
    130                 135         


<210>  131
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<400>  131
caggtgcagc tcgtggagac cggcggagga acggtgcana ctgggggctc tctgagactc       60

tcctgttcag cctctggcgg ctccttcagt aggaatgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgaatt tgtagcagct attaactgga gtgcctctag tacttattat      180

agagactccg tgaagggacg attcaccgtc tccagagaca acgccaagaa cacggtgtat      240

ctgcatttga acagcctgaa acttgaggac acggccgcgt attactgtgc tggaagctcg      300

gtgtatgcag aaatgccgta cgccgactct gtcaaggcaa cttcctataa ctactggggc      360

caggggaccc aggtcaccgt ctcctcagaa cccaagacac caaaaccaca a               411


<210>  132
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  132

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Pro Cys Ser Phe Ser Gly Phe Pro Phe Asp Asn Tyr 
            20                  25                  30          


Phe Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Asp Phe Leu Thr Pro His Arg Cys Pro Ala Leu Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu 
        115                 120                 125             


Asp Pro Ser 
    130     


<210>  133
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  133
caggtgcagc tcgtggagac cgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

ccctgttcat tctctggatt ccctttcgat aattatttcg taggctggtt ccgccaggcc      120

ccagggaagg agcgtgaggg ggtctcatgt attagtagta gtgatggtag cacatactat      180

gcagactccg tgaagggccg gttcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga acagtctgaa acctgaggat acggccgttt attactgtgg agcagatttc      300

ctcaccccac ataggtgtcc agccttatat gactactggg gccaggggac ccaggtcacc      360

gtctcctcag cgcaccacag cgaagacccc tcg                                   393


<210>  134
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  134

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu His Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile Tyr 
            20                  25                  30          


Arg Thr Cys Trp Tyr Arg Gln Gly Thr Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Asp Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Glu Ala Gly Ile Gly Gly Phe Asn Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu Asp Pro Ser 
        115                 120                 125         


<210>  135
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  135
caggtgcagc tcgtggagtc tggtggaggc ttggtgcagc ctggggggtc tctgagactc       60

cactgtgcag cctctggaag catcgccagt atctatcgca cgtgctggta ccgccagggc      120

acagggaagc agcgcgagtt ggtcgcagcc attactagtg gtggtaacac atactatgcg      180

gactccgtta agggccgatt caccatctcc agagacaacg ccaaaaacac aatcgatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtctatt actgtaatgc agacgaggcg      300

gggatcgggg gatttaatga ctactggggc caggggaccc aggtcaccgt ctcctcagcg      360

caccacagcg aagacccctc g                                                381


<210>  136
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  136

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Ser 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Val Trp Ala Asp Gly Thr Thr Leu Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Val Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Asn Lys Phe Val Arg Gly Leu Val Ala Val Arg Ala Ile Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             


Lys Thr Pro Lys Pro Gln 
    130                 


<210>  137
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  137
caggtgcagc tcgtggagtc ggggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccttcagt cgcagttcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgaatt cgttgcgtcc attgtctggg ctgatggtac gacgttgtat      180

ggagactccg taaagggccg attcaccgtc tccagggaca acgtcaagaa catggtgtat      240

ctacaaatga acaacctgaa acctgaggac acggcccttt attactgtgc ggacaataaa      300

ttcgtccgtg gattagtggc tgtccgtgcg atagattatg actactgggg ccaggggacc      360

caggtcaccg tctcgtcaga acccaagaca ccaaaaccac aa                         402


<210>  138
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  138

Gln Val Gln Leu Val Glu Ser Gly Gly Leu Val Gln Ala Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Asp Ile Ile Tyr Ala 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        35                  40                  45              


Ala Val Asp Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Ser Trp Tyr Arg Asp Ala Leu Ser Pro Ser Arg Val Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Thr Pro Lys Pro Gln 
    130                 135 


<210>  139
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  139
caggtgcagc tcgtggagtc gggaggattg gtgcaggctg gaggctctct gagactctcc       60

tgcgcagcct ctggacgcgc cgacataatc tatgccatgg gctggttccg ccaggctcca      120

gggaaggagc gtgagtttgt agcggcagta gactggagtg gtggtagcac atactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaactc ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtttatt actgtgcagc ccgaaggagc      300

tggtaccgag acgcgctatc cccctcccgg gtgtatgaat atgactactg gggccagggg      360

acccaggtca ccgtctcctc agaacccaag acaccaaaac cacaa                      405


<210>  140
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  140

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Gly Ser Gly Gly Thr Leu Glu His Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Trp Leu 
        35                  40                  45              


Val Cys Asn Arg Gly Glu Tyr Gly Ser Thr Val Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ala Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Pro Asp Asp Thr Gly Ile Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Cys Tyr Ser Trp Arg Gly Pro Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala His His Ser Glu Asp Pro Ser 
        115                 120                 125 


<210>  141
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  141
caggtgcagc tcgtggagac gggaggaggc ttggtgcagc ctggggggtc tctgacactc       60

tcctgtgcag gctccggtgg cactttggaa cattatgcta taggctggtt ccgccaggcc      120

cctgggaaag agcatgagtg gctcgtatgt aatagaggtg aatatgggag cactgtctat      180

gtagactccg tgaagggccg attcaccgcc tccagagaca acgccaagaa cacggtgtat      240

ctgcaattga acagtctgaa acctgacgac acaggcattt attactgtgt atcgggatgt      300

tactcctggc ggggtccctg gggccagggg acccaggtca ccgtctcctc ggcgcaccac      360

agcgaagacc cctcg                                                       375


<210>  142
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  142

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Arg Ala Ser Gly Ser Ile Val Ser Ile Tyr 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Leu 
        35                  40                  45              


Ala Ala Ile Thr Thr Asp Gly Ser Thr Lys Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ile Tyr Ser Cys Ile 
                85                  90                  95      


Gly Asp Ala Ala Gly Trp Gly Asp Gln Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125     


<210>  143
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  143
caggtgcagc tcgtggagtc tgggggaggt ttggtgcagc ctggggggtc tctgaaactc       60

tcctgtagag cctctggaag catagtcagt atctatgccg tgggctggta ccgccaggct      120

ccagggaagc agcgcgagtt gctcgcggct atcactactg atggtagcac gaagtactca      180

gactccgtga agggccgatt caccatctcc cgagacaacg ccaagaacac ggtatatctg      240

caaatgaaca acctcaaacc tgaggacacg gccatctatt cctgtatcgg ggacgcggcg      300

ggttggggcg accaatacta ctggggccag gggacccagg tcaccgtctc ctcagaaccc      360

aagacaccaa aaccacaa                                                    378


<210>  144
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  144

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Val Asn Phe Glu 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Asn Glu Gly Ser Ser Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Thr Phe Gly Ser Arg Trp Pro Tyr Ala His Ser Asp His Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120                 125             


Gln 
    


<210>  145
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  145
caggtgcagc tcgtggagtc aggcggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag catcgtcaat ttcgaaacca tgggctggta ccgccaggct      120

ccagggaagg agcgcgagtt ggtcgcaact attactaatg aaggtagttc aaactatgca      180

gactccgtga agggccgatt caccatctcc ggagacaacg ccaagaacac ggtgtccctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtctact actgttcggc gacgttcggc      300

agtaggtggc cgtacgccca cagtgatcac tggggccagg ggacccaggt caccgtctcc      360

tcagaaccca agacaccaaa accacaa                                          387


<210>  146
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  146

Gln Val Gln Leu Val Glu Thr Gly Gly Ala Leu Val His Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Ser Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ala Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Lys Trp Val 
        35                  40                  45              


Ala Gly Ile Met Pro Asp Gly Thr Pro Ser Tyr Val Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu 
65                  70                  75                  80  


His Met Asn Asn Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Gln Trp Pro Arg Thr Met Pro Asp Ala Asn Trp Gly Arg Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125 


<210>  147
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  147
caggtgcagc tcgtggagac gggcggagca ttggtgcaca ctgggggttc tctgagactc       60

tcctgcgaag tctccggaag caccttcagt agctatggca tggcctggta ccgccaagct      120

ccaggcgagc agcgtaagtg ggtcgcaggt attatgccgg atggtactcc aagctatgta      180

aactccgtga agggccgatt caccatctcc agagacaacg ccaagaactc ggtgtatctg      240

cacatgaaca acctgaggcc tgaagacacg gccgtctatt attgcaacca atggccgcgc      300

acgatgcctg acgcgaactg gggccggggg acccaggtca ccgtctcctc agaacccaag      360

acaccaaaac cacaa                                                       375


<210>  148
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  148

Gln Val Gln Leu Val Glu Thr Gly Gly Ser Leu Arg Leu Thr Cys Val 
1               5                   10                  15      


Thr Ser Gly Ser Thr Phe Asn Asn Pro Ala Ile Thr Trp Tyr Arg Gln 
            20                  25                  30          


Pro Pro Gly Lys Gln Arg Glu Trp Val Ala Ser Leu Arg Ser Gly Asp 
        35                  40                  45              


Gly Pro Val Tyr Arg Glu Ser Val Lys Gly Arg Phe Thr Ile Phe Arg 
    50                  55                  60                  


Asp Asn Ala Thr Asp Ala Leu Tyr Leu Arg Met Asn Ser Leu Lys Pro 
65                  70                  75                  80  


Glu Asp Thr Ala Val Tyr His Cys Asn Thr Ala Ser Pro Ala Ser Trp 
                85                  90                  95      


Leu Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
            100                 105                 110         


Thr Pro Lys Pro Gln 
        115         


<210>  149
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  149
caggtgcagc tcgtggagac tggggggtct ctgaggctca cctgtgtaac ctctggaagc       60

accttcaata atcctgccat aacctggtac cgccagcctc cagggaagca gcgtgagtgg      120

gtcgcaagtc ttcgtagtgg tgatggtcca gtatataggg aatccgtgaa gggccgattc      180

accattttta gagacaacgc cacggacgcg ctgtatctgc ggatgaatag cctgaaacct      240

gaggacacgg ccgtctatca ctgtaacacc gcctcacctg ctagttggct ggactggggc      300

caggggaccc aggtcactgt ctcctcagaa cccaagacac caaaaccaca a               351


<210>  150
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  150

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Pro Phe Ser Thr Glu 
            20                  25                  30          


Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Glu Gly Gly Glu Thr Thr Leu Ala Ala Pro Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Asn Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Phe Arg Gly Val Phe Phe Arg Thr Ser Phe Pro Pro Glu Leu Ala Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys 
        115                 120                 125             


Pro Gln 
    130 


<210>  151
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  151
caggtgcagc tcgtggagac gggaggagga ttggtgcaac ctgggggttc tctgagactc       60

tcttgtgcaa cctctggatt ccccttcagt acggagcgta tgagctgggt ccgccaggct      120

ccaggaaagg ggctcgagtg ggtctcaggt attactgagg gtggtgaaac cactctcgcg      180

gcaccctccg tgaagggccg attcaacatc tccagagaca acgccaggaa tatcctatat      240

ctacagatga attccttgaa acctgaggac gcggccgttt actattgttt tagaggtgtt      300

ttttttagaa cgagttttcc tcccgaactc gcgcggggcc aggggaccca ggtcaccgtc      360

tcctcagaac ccaagacacc aaaaccacaa                                       390


<210>  152
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  152

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ala Val Ser Asp Ser 
            20                  25                  30          


Phe Ser Thr Tyr Ala Ile Ser Trp His Arg Gln Ala Pro Gly Lys Gln 
        35                  40                  45              


Arg Glu Trp Ile Ala Gly Ile Ser Asn Arg Gly Ala Thr Ser Tyr Arg 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Gly Val 
                85                  90                  95      


Tyr Tyr Cys Glu Pro Trp Pro Arg Glu Gly Leu Gly Gly Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125         


<210>  153
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  153
caggtgcagc tcgtggagtc gggcggaggc ttggtgcagg caggggggtc tttgagactc       60

tcctgtgcag cctctggaag cgccgtcagt gacagcttca gtacctatgc catctcctgg      120

caccgccagg ctccagggaa gcagcgtgag tggatcgcag gtattagtaa tcgtggtgcg      180

acaagctata gagactccgt gaagggccga ttcaccatct ccagagacaa cgccaagaac      240

acggtatatc tgcaaatgaa caacctgaaa cctgaggaca cgggcgtcta ttattgtgag      300

ccatggccac gcgaaggact tggggggggc caggggactc aggtcaccgt ctcctcagaa      360

cccaagacac caaaaccaca a                                                381


<210>  154
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  154

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Val Ser Gly Ser Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Val Ala Trp Tyr Arg Gln Val Pro Gly Lys Ser Arg Ala Trp Val 
        35                  40                  45              


Ala Gly Val Ser Thr Thr Gly Ser Thr Ser Tyr Thr Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn His Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Ser Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Ile Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Trp Pro Phe Thr Asn Pro Pro Ser Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala His His Ser Glu Asp Pro Ser 
        115                 120                 


<210>  155
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<400>  155
caggtgcagc tcgtggagtc ggggggaggc tcggtgcana ctggggggtc tctgacactc       60

tcctgtgtag tctctggaag taccttcagt gactatgcgg tggcctggta ccgccaggtt      120

ccaggcaaat cgcgtgcgtg ggtcgcgggt gttagtacta ctggctcgac atcttataca      180

gactccgtga ggggccggtt caccatctcc agagacaacc acaagaagac ggtgtatctt      240

tcaatgaaca gcctgaaacc tgaggacacg ggcatctatt actgcaactt atggccgttc      300

acaaatcctc cttcctgggg ccagggaacc caagtcaccg tttcctcggc gcaccacagc      360

gaagacccct cg                                                          372


<210>  156
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  156

Gln Val Gln Leu Val Glu Ser Gly Gly Ala Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Asp 
            20                  25                  30          


Arg Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Thr Ala Ser Glu Gly Phe Ala Thr Leu Tyr Ala Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys His Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asp Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Leu Arg Gly Val Phe Phe Arg Thr Asn Ile Pro Pro Glu Val 
            100                 105                 110         


Leu Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser 
        115                 120                 125             


Glu Asp Pro Ser 
    130         


<210>  157
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  157
caggtgcagc tcgtggagtc tggaggagcc gtggtgcaac ctgggggttc tctgagactc       60

tcctgtgcaa cctctggatt caccttcagt gacgatcgta tgagctgggc ccgccaggct      120

ccaggaaagg ggctcgagtg ggtctcaggt attagtactg ctagtgaagg ttttgctaca      180

ctctacgcac cctccgtgaa gggccgattc accatctcca gagacaacgc caagcatatg      240

ctgtatctgc aaatggatac cttgaaacct gaggacacgg ccgtgtatta ctgtttaaga      300

ggggtttttt ttagaacgaa cattcctccc gaggtactgc ggggccaggg gacccaggtc      360

accgtctcct cagcgcacca cagcgaagac ccctcg                                396


<210>  158
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  158

Gln Val Gln Leu Val Glu Thr Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Ser Arg Ala 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Arg Leu Ala Ser Gly Asp Met Thr Asp Tyr Thr Glu Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys His Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Arg Ile Pro Pro Tyr Tyr Ser Ile Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Arg Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125     


<210>  159
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (355)..(355)
<223>  n is a, c, g, or t

<400>  159
caggtgcagc tcgtggagac ggggggagac ttggtgcanc ctggggggtc tctgagactc       60

tcctgtgcag cctctggaag ctccttcagc cgcgctgccg tgggctggta ccgtcaggct      120

ccaggaaagg agcgtgagtg ggtcgcacgt ctcgcgagtg gtgatatgac ggactatacc      180

gagtccgtga ggggccgatt cactatctcc agagacaacg ccaagcacac ggtgtatctg      240

caaatggaca acctgaaacc tgaggacacg gccgtctact attgtaaggc caggataccc      300

ccttattact ctatagagta ctggggcaaa gggacccggg tcaccgtctc ctcanaaccc      360

aagacaccaa aaccacaa                                                    378


<210>  160
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  160

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Ser Pro Leu Phe Asn Leu Tyr 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Leu Thr Asp Gly Arg Ala Thr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asn Asn Leu Thr Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Arg Lys Asn Ser Ile Tyr Trp Asp Ser Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 


<210>  161
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  161
caggtgcagc tcgtggagac aggtggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgtag tatctagtcc cctgttcaat ctttacgaca tggcctggta tcgccaggct      120

ccagggaatc agcgtgagtt ggtcgcaggc atcttgactg atggtcgcgc aacatattca      180

gacagcgtga agggccgatt caccatttcc agaaacaacc tgacgaacac ggtgttttta      240

caaatgagca gcctgaaacc tgaggacacg gccgtctatt attgtaatag aaagaatagt      300

atctactggg attcctgggg ccaggggacc caggtcaccg tctcctcgga acccaagaca      360

ccaaaaccac aa                                                          372


<210>  162
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  162

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Val Val Val 
        35                  40                  45              


Ser Val Ile Ser Pro Asp Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Thr Leu Arg Phe Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Gly Pro Arg Asn Gly Ala Thr Thr Val Leu Arg Pro Gly Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             


Lys Thr Pro Lys Pro Gln 
    130                 


<210>  163
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized. The antibody is a
       camelid (VHH)

<400>  163
caggtgcagc tcgtggagtc ggggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgcgtag cctctggact caccttcagt cgctatggca tgggctggtt ccgccaggct      120

ccaggacagg agcgtgtagt cgtatcagtt attagtcccg acggtggtag cgcatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga gcaccctgag atttgaggac acgggcgttt attattgtac agcagggccc      300

cggaatggag cgactacagt cctccggcca ggggattatg actactgggg ccaggggacc      360

caggtcactg tctcctcaga acccaagaca ccaaaaccac aa                         402


<210>  164
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid was designed and synthesized

<400>  164

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            100                 105                 110         


Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Glu 
        115                 120                 125             


Pro Lys Thr Pro Lys Pro Gln 
    130                 135 


<210>  165
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid sequence was designed and synthesized

<400>  165

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
            20                  25                  30          


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys 
                85                  90                  95      


Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser Glu 
            100                 105                 110         


Pro Lys Thr Pro Lys Pro Gln 
        115                 


<210>  166
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid sequence was designed and synthesized

<400>  166

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120                 125             


Gln 
    


<210>  167
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid sequence was designed and synthesized

<400>  167

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
        35                  40                  45              


Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    50                  55                  60                  


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
65                  70                  75                  80  


Asp Tyr Ser Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
                85                  90                  95      


Glu Gly Val Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala 
            100                 105                 110         


Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn 
        115                 120                 125             


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
    130                 135                 140                 


Tyr Tyr Cys Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu 
145                 150                 155                 160 


Ser Pro Tyr Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val 
                165                 170                 175     


Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Pro Thr Ser Ala Ile Ala 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        195                 200                 205             


Ala Ala Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    210                 215                 220                 


Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp 
225                 230                 235                 240 


Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu 
                245                 250                 255     


Ala Val Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp 
            260                 265                 270         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala 
        275                 280                 285             


Val Tyr Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr 
    290                 295                 300                 


Tyr Cys Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu 
305                 310                 315                 320 


Ala Asp Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser 
                325                 330                 335     


Ser Glu Pro Lys Thr Pro Lys Pro Gln Thr Ser Ala Leu Val Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Ala 
        355                 360                 365             


Met Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    370                 375                 380                 


Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile 
385                 390                 395                 400 


Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser 
                405                 410                 415     


Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser 
            420                 425                 430         


Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val 
    450                 455                 460                 


Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr 
465                 470                 475                 480 


Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Ala Ile Ala Gly Gly 
                485                 490                 495     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Gly 
            500                 505                 510         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        515                 520                 525             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
    530                 535                 540                 


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
545                 550                 555                 560 


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
                565                 570                 575     


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
            580                 585                 590         


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
        595                 600                 605             


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
    610                 615                 620                 


Pro Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
625                 630                 635                 640 


Gln Pro Ala Arg Gln Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu 
                645                 650                 655     


Pro Arg Gly Gly Gly Ser Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu 
            660                 665                 670         


Trp Glu Asp 
        675 


<210>  168
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag

<400>  168

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10              


<210>  169
<211>  2373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The nucleotide sequence was designed and synthesized

<400>  169
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg       60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc      120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac      180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg      240

ctgttcaaaa acggtgaagt ggcggcaacc aaagtgggtg cactgtctaa aggtcagttg      300

aaagagttcc tcgacgctaa cctggccggt tctggttctg gccatatgca ccatcatcat      360

catcattctt ctggtctggt gccacgcggt tctggtatga aagaaaccgc tgctgctaaa      420

ttcgaacgcc agcacatgga cagcccagat ctgggtaccg acgacgacga caaggccatg      480

gcgatatcgg atccgaattc tggcgcacct gtcccatacc cagaccctct ggaaccacga      540

gcggccgccc aagtccaact ggtcgaaagt ggtggtggtc tggtccaacc gggtggctct      600

ctgcgtctgt cctgcgctgc gagtggtttt accctggatt atagctctat tggttggttc      660

cgccaggcgc cgggtaaaga acgtgaaggc gtgagctgca tcagttcctc aggtgatagt      720

accaaatatg cggactccgt caaaggccgc tttaccacga gtcgtgataa cgccaaaaat      780

acggtttacc tgcagatgaa ctccctgaaa ccggatgaca ccgcagtgta ttactgcgcg      840

gcctttcgcg ctacgatgtg tggtgttttc ccgctgagcc cgtatggcaa agatgactgg      900

ggtaaaggca ccctggtgac ggtttcgagc gaaccgaaaa ccccgaaacc gcagccgacg      960

tctgcgatcg ccggtggtgg tggttcgggt ggtggtggta gcggtggtgg tggttctgca     1020

gctgcgcagc tgcaactggt ggaaagcggc ggtggtctgg ttcaaccggg tggttccctg     1080

cgtctgtcat gcgaagcctc gggttttacc ctggattatt acggtattgg ttggttccgt     1140

cagccgccgg gcaaagaacg tgaagcagtg agctatattt ccgcatcagc acgtaccatc     1200

ctgtacgcag attcagttaa aggccgcttt acgatctcgc gtgacaacgc gaaaaatgcc     1260

gtctatctgc agatgaacag tctgaaacgt gaagataccg cagtgtatta ctgtgctcgt     1320

cgccgtttct ccgcgtctag tgtcaatcgc tggctggccg atgactacga tgtgtggggt     1380

cgtggcaccc aagtcgccgt gtcctcagag cctaaaacgc cgaaaccgca aacgtctgca     1440

ctagttggcg gtggtggctc aggtggaggc gggtcaggcg gtggcggttc cctgcaagca     1500

atggccgcag ctcaggtgca actggttgaa tccggtggtg gtctggtgca gaccggtggt     1560

agcctgcgtc tgtcttgcgc atcgagcggt agcattgctg gctttgaaac cgttacgtgg     1620

tctcgtcaag cgccgggtaa atcactgcag tgggtcgcct cgatgaccaa aacgaacaat     1680

gaaatctatt cggatagcgt taaaggccgc tttattatct cacgcgataa cgcgaaaaat     1740

accgtgtatc tgcagatgaa ctcgctgaaa ccggaagata cgggtgttta cttctgcaaa     1800

ggcccggaac tgcgcggtca aggcattcag gttaccgtct ctagtgagcc taaaaccccg     1860

aaaccgcaag caatcgcagg cggcggcggc agcggcggcg gcggctctgg tggtggtggt     1920

tccctgcagg gtcaagtcca gctggtggaa tctggcggtg gtctggtgca accgggtggt     1980

agtctgcgtc tgtcctgtgc agcctcaggc tttaccttct cagattatgt tatgacgtgg     2040

gtccgtcagg caccgggtaa aggtccggaa tggattgcta ccatcaatac ggacggtagc     2100

accatgcgcg atgactctac caaaggccgc ttcacgatta gccgtgataa tgccaaaaat     2160

accctgtacc tgcagatgac gtctctgaaa ccggaagaca ccgcgctgta ttactgtgcc     2220

cgcggtcgtg ttatttctgc aagtgctatc cgtggcgccg tccgtggtcc gggcacccaa     2280

gtcaccgtct cctcagaacc gaaaacgccg aaaccgcaac cggcgcgcca gggtgcgccg     2340

gtgccgtatc cggacccgct ggaaccgcgt taa                                  2373


<210>  170
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid was designed and synthesized

<400>  170

Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      


Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          


Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              


Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  


Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      


Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala Gly Ser Gly 
            100                 105                 110         


Ser Gly His Met His His His His His His Ser Ser Gly Leu Val Pro 
        115                 120                 125             


Arg Gly Ser Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln 
    130                 135                 140                 


His Met Asp Ser Pro Asp Leu Gly Thr Asp Asp Asp Asp Lys Ala Met 
145                 150                 155                 160 


Ala Ile Ser Asp Pro Asn Ser Gly Ala Pro Val Pro Tyr Pro Asp Pro 
                165                 170                 175     


Leu Glu Pro Arg Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
            180                 185                 190         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        195                 200                 205             


Gly Phe Thr Leu Asp Tyr Ser Ser Ile Gly Trp Phe Arg Gln Ala Pro 
    210                 215                 220                 


Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Ser Ser Ser Gly Asp Ser 
225                 230                 235                 240 


Thr Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp 
                245                 250                 255     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp 
            260                 265                 270         


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Phe Arg Ala Thr Met Cys Gly 
        275                 280                 285             


Val Phe Pro Leu Ser Pro Tyr Gly Lys Asp Asp Trp Gly Lys Gly Thr 
    290                 295                 300                 


Leu Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Pro Thr 
305                 310                 315                 320 


Ser Ala Ile Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                325                 330                 335     


Gly Gly Ser Ala Ala Ala Gln Leu Gln Leu Val Glu Ser Gly Gly Gly 
            340                 345                 350         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly 
        355                 360                 365             


Phe Thr Leu Asp Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly 
    370                 375                 380                 


Lys Glu Arg Glu Ala Val Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile 
385                 390                 395                 400 


Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                405                 410                 415     


Ala Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Arg Glu Asp 
            420                 425                 430         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Phe Ser Ala Ser Ser Val 
        435                 440                 445             


Asn Arg Trp Leu Ala Asp Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln 
    450                 455                 460                 


Val Ala Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Thr Ser Ala 
465                 470                 475                 480 


Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Leu Gln Ala Met Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
            500                 505                 510         


Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser 
        515                 520                 525             


Ser Gly Ser Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala 
    530                 535                 540                 


Pro Gly Lys Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn 
545                 550                 555                 560 


Glu Ile Tyr Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp 
                565                 570                 575     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            580                 585                 590         


Asp Thr Gly Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly 
        595                 600                 605             


Ile Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Ala 
    610                 615                 620                 


Ile Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Leu Gln Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                645                 650                 655     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            660                 665                 670         


Phe Ser Asp Tyr Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly 
        675                 680                 685             


Pro Glu Trp Ile Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp 
    690                 695                 700                 


Asp Ser Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
705                 710                 715                 720 


Thr Leu Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                725                 730                 735     


Tyr Tyr Cys Ala Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly 
            740                 745                 750         


Ala Val Arg Gly Pro Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
        755                 760                 765             


Thr Pro Lys Pro Gln Pro Ala Arg Gln Gly Ala Pro Val Pro Tyr Pro 
    770                 775                 780                 


Asp Pro Leu Glu Pro Arg Gly Gly Gly Ser Asp Ile Cys Leu Pro Arg 
785                 790                 795                 800 


Trp Gly Cys Leu Trp Glu Asp 
                805         


<210>  171
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid was designed and synthesized

<400>  171

Gln Gly Val Gln Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu 
1               5                   10                  15      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            20                  25                  30          


Thr Leu Asp Tyr Ser Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Gly Val Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe 
            100                 105                 110         


Pro Leu Ser Pro Tyr Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Val Gln Ser 
145                 150                 155                 160 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            180                 185                 190         


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        195                 200                 205             


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            260                 265                 270         


Pro Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        275                 280                 285             


Gln 
    


<210>  172
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid was designed and synthesized

<400>  172

Gln Gly Val Gln Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu 
1               5                   10                  15      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe 
            20                  25                  30          


Thr Leu Asp Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Ala Val Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn 
            100                 105                 110         


Arg Trp Leu Ala Asp Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val 
        115                 120                 125             


Ala Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Val Gln Ser 
145                 150                 155                 160 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
            180                 185                 190         


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
        195                 200                 205             


Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys 
                245                 250                 255     


Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser Glu 
            260                 265                 270         


Pro Lys Thr Pro Lys Pro Gln 
        275                 


<210>  173
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The amino acid was designed and synthesized

<400>  173

Gln Gly Val Gln Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu 
1               5                   10                  15      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            20                  25                  30          


Thr Leu Asp Tyr Ser Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Gly Val Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe 
            100                 105                 110         


Pro Leu Ser Pro Tyr Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Val Gln Ser 
145                 150                 155                 160 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            180                 185                 190         


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        195                 200                 205             


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            260                 265                 270         


Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Glu 
        275                 280                 285             


Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Gln Gly Val Gln Ser Gln Val Gln Leu Val 
305                 310                 315                 320 


Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser 
                325                 330                 335     


Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu Thr Val Thr Trp Ser 
            340                 345                 350         


Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val Ala Ser Met Thr Lys 
        355                 360                 365             


Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys Gly Arg Phe Ile Ile 
    370                 375                 380                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 


Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg 
                405                 410                 415     


Gly Gln Gly Ile Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys 
            420                 425                 430         


Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gln Gly Val Gln Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Phe Ser Asp Tyr Val Met Thr Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Pro Glu Trp Ile Ala Thr Ile Asn Thr Asp Gly Ser Thr Met 
            500                 505                 510         


Arg Asp Asp Ser Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        515                 520                 525             


Lys Asn Thr Leu Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr 
    530                 535                 540                 


Ala Leu Tyr Tyr Cys Ala Arg Gly Arg Val Ile Ser Ala Ser Ala Ile 
545                 550                 555                 560 


Arg Gly Ala Val Arg Gly Pro Gly Thr Gln Val Thr Val Ser Ser Glu 
                565                 570                 575     


Pro Lys Thr Pro Lys Pro Gln 
            580             







